3wi6 A 2.99 BS01 YRZ A 1 A91 E139 L141 E190 N191 L193 D207 A46 E94 L96 E142 N143 L145 D159 D186 K188 E190 N191 D207 S216 D138 K140 E142 N143 D159 S168 2.7.11.1 0004672,0005524,0006468 -logKd/Ki=5.33, IC50=4.7uM P49137 24316826 901 FHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSPYYVAPEVLGPEDKSCDMWSLGVIMYILLCGYPPFYSISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKE 3wi6 B 2.99 BS01 YRZ B 1 A91 E139 L141 E190 N191 L193 D207 A46 E94 L96 E143 N144 L146 D160 D186 K188 E190 N191 D207 S216 D139 K141 E143 N144 D160 S169 2.7.11.1 0004672,0005524,0006468 P49137 24316826 901 FHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSPYYVAPEVLGPEDKSCDMWSLGVIMYILLCGYPPFYSISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKE 3wi6 C 2.99 BS01 YRZ C 1 E139 L141 E190 N191 L193 D207 E94 L96 E143 N144 L146 D160 D186 K188 E190 N191 D207 S216 D139 K141 E143 N144 D160 S169 2.7.11.1 0004672,0005524,0006468 P49137 24316826 901 FHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSPYYVAPEVLGPEDKSCDMWSLGVIMYILLCGYPPFYSISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKE 3wi6 D 2.99 BS01 YRZ D 1 A91 E139 L141 E190 N191 L193 D207 A46 E94 L96 E142 N143 L145 D159 D186 K188 E190 N191 D207 S216 D138 K140 E142 N143 D159 S168 2.7.11.1 0004672,0005524,0006468 P49137 24316826 901 FHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSPYYVAPEVLGPEDKSCDMWSLGVIMYILLCGYPPFYSISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKE 3wi6 E 2.99 BS01 YRZ E 1 A91 E139 L141 E190 N191 L193 D207 A46 E94 L96 E143 N144 L146 D160 D186 K188 E190 N191 D207 S216 D139 K141 E143 N144 D160 S169 2.7.11.1 0004672,0005524,0006468 P49137 24316826 901 FHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSPYYVAPEVLGPEDKSCDMWSLGVIMYILLCGYPPFYSISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKE 3wi6 F 2.99 BS01 YRZ F 1 E139 L141 E190 N191 L193 D207 E94 L96 E143 N144 L146 D160 D186 K188 E190 N191 D207 S216 D139 K141 E143 N144 D160 S169 2.7.11.1 0004672,0005524,0006468 P49137 24316826 901 FHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSPYYVAPEVLGPEDKSCDMWSLGVIMYILLCGYPPFYSISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKE