5hia A 1.773 BS01 YPG A 1 K68 G69 I135 D137 T138 G139 K140 T141 K165 F186 V187 L192 D193 R199 K67 G68 I120 D122 T123 G124 K125 T126 K150 F171 V172 L177 D178 R184 E133 D134 D137 F186 R199 E118 D119 D122 F171 R184 2.4.2.8 0000166,0000287,0001913,0001975,0004422,0005515,0005737,0005829,0006164,0006166,0006178,0007625,0007626,0016757,0021756,0021895,0021954,0032263,0032264,0042417,0042802,0043103,0044209,0045964,0046038,0046040,0046083,0046100,0046651,0046872,0048813,0051289,0052657,0070062,0071542 Ki=3.0nM P00492 29161011 301 TRSPGVVISDDEPGYDLDLFAIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLIKVIDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVAVISETGKAKYKA 5hia B 1.773 BS01 YPG B 1 K68 I135 D137 T138 G139 T141 K165 F186 V187 L192 D193 R199 K66 I122 D124 T125 G126 T128 K152 F173 V174 L179 D180 R186 E133 D134 D137 F186 R199 E120 D121 D124 F173 R186 2.4.2.8 0000166,0000287,0001913,0001975,0004422,0005515,0005737,0005829,0006164,0006166,0006178,0007625,0007626,0016757,0021756,0021895,0021954,0032263,0032264,0042417,0042802,0043103,0044209,0045964,0046038,0046040,0046083,0046100,0046651,0046872,0048813,0051289,0052657,0070062,0071542 Ki=3.0nM P00492 29161011 301 RSPGVVISDDEPGYDLDLFAIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVAVISETGKAKYKA 5hia C 1.773 BS01 YPG C 1 K68 G69 I135 D137 T138 G139 K140 T141 K165 F186 V187 D193 R199 K65 G66 I124 D126 T127 G128 K129 T130 K154 F175 V176 D182 R188 E133 D134 D137 F186 R199 E122 D123 D126 F175 R188 2.4.2.8 0000166,0000287,0001913,0001975,0004422,0005515,0005737,0005829,0006164,0006166,0006178,0007625,0007626,0016757,0021756,0021895,0021954,0032263,0032264,0042417,0042802,0043103,0044209,0045964,0046038,0046040,0046083,0046100,0046651,0046872,0048813,0051289,0052657,0070062,0071542 Ki=3.0nM P00492 29161011 301 SPGVVISDDEPGYDLDLFAIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKGDIKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVAVISETGKAKYKA 5hia D 1.773 BS01 YPG D 1 K68 G69 I135 D137 T138 G139 T141 K165 F186 V187 L192 D193 R199 K65 G66 I123 D125 T126 G127 T129 K153 F174 V175 L180 D181 R187 E133 D134 D137 F186 R199 E121 D122 D125 F174 R187 2.4.2.8 0000166,0000287,0001913,0001975,0004422,0005515,0005737,0005829,0006164,0006166,0006178,0007625,0007626,0016757,0021756,0021895,0021954,0032263,0032264,0042417,0042802,0043103,0044209,0045964,0046038,0046040,0046083,0046100,0046651,0046872,0048813,0051289,0052657,0070062,0071542 Ki=3.0nM P00492 29161011 301 SPGVVISDDEPGYDLDLFAIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKDIKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVAVISETGKAKYKA 5kny A 2.91 BS01 YPG A 1 G67 D126 S127 G128 L129 T130 K154 F175 V176 L181 D182 R188 G45 D101 S102 G103 L104 T105 K129 F150 V151 L156 D157 R163 E122 D123 D126 F175 R188 E97 D98 D101 F150 R163 2.4.2.8 0000166,0000287,0004422,0005737,0005829,0006166,0006177,0006178,0006188,0016757,0032263,0032264,0043101,0046100,0046872,0052657 Ki=60nM P9WHQ9 301 ELYPGDIKSVLLTAEQIQARIAELGEQIGNDYRGQDLLLITVLKGAVLFVTDLARAIPVPTQFEFMAVSSYGSSSGVVRILKDLDRDIHGRDVLIVEDVVDSGLTLSWLSRNLTSRNPRSLRVCTLLRKPDAVHANVEIAYVGFDIPNDFVVGYGLDYDERYRDLSYIGTLDPRVY 5kny B 2.91 BS01 YPG B 1 G67 D126 S127 G128 T130 K154 F175 V176 L181 D182 R188 G52 D111 S112 G113 T115 K139 F160 V161 L166 D167 R173 E122 D123 D126 F175 R188 E107 D108 D111 F160 R173 2.4.2.8 0000166,0000287,0004422,0005737,0005829,0006166,0006177,0006178,0006188,0016757,0032263,0032264,0043101,0046100,0046872,0052657 Ki=60nM P9WHQ9 301 AELYPGDIKSVLLTAEQIQARIAELGEQIGNDYRELSATTGQDLLLITVLKGAVLFVTDLARAIPVPTQFEFMAVSSYGSSTSSSGVVRILKDLDRDIHGRDVLIVEDVVDSGLTLSWLSRNLTSRNPRSLRVCTLLRKPDAVHANVEIAYVGFDIPNDFVVGYGLDYDERYRDLSYIGTLDPRVYQ 5kny C 2.91 BS01 YPG C 1 K66 G67 V125 D126 S127 G128 T130 K154 F175 V176 L181 D182 R188 K49 G50 V108 D109 S110 G111 T113 K137 F158 V159 L164 D165 R171 E122 D123 D126 F175 R188 E105 D106 D109 F158 R171 2.4.2.8 0000166,0000287,0004422,0005737,0005829,0006166,0006177,0006178,0006188,0016757,0032263,0032264,0043101,0046100,0046872,0052657 Ki=60nM P9WHQ9 301 LYPGDIKSVLLTAEQIQARIAELGEQIGNDYRELSATTGQDLLLITVLKGAVLFVTDLARAIPVPTQFEFMAVSSYGSSTSSSGVVRILKDLDRDIHGRDVLIVEDVVDSGLTLSWLSRNLTSRNPRSLRVCTLLRKPDAVHANVEIAYVGFDIPNDFVVGYGLDYDERYRDLSYIGTLDPRV 5kny D 2.91 BS01 YPG D 1 K66 G67 V125 G128 T130 L131 K154 F175 V176 L181 D182 R188 K49 G50 V108 G111 T113 L114 K137 F158 V159 L164 D165 R171 E122 D123 D126 F175 R188 E105 D106 D109 F158 R171 2.4.2.8 0000166,0000287,0004422,0005737,0005829,0006166,0006177,0006178,0006188,0016757,0032263,0032264,0043101,0046100,0046872,0052657 Ki=60nM P9WHQ9 301 LYPGDIKSVLLTAEQIQARIAELGEQIGNDYRELSATTGQDLLLITVLKGAVLFVTDLARAIPVPTQFEFMAVSSYGSSTSSSGVVRILKDLDRDIHGRDVLIVEDVVDSGLTLSWLSRNLTSRNPRSLRVCTLLRKPDAVHANVEIAYVGFDIPNDFVVGYGLDYDERYRDLSYIGTLDPRV 6bo7 A 2.856 BS02 YPG A 1 K77 D148 T149 G150 T152 K176 F197 V198 L203 D204 R210 K79 D140 T141 G142 T144 K168 F189 V190 L195 D196 R202 E144 D145 D148 F197 R210 E136 D137 D140 F189 R202 2.4.2.8 0000166,0000287,0004422,0005737,0005829,0006166,0006178,0016757,0032263,0032264,0046100,0046872,0052657 A5K7E9 29161011 303 HHHKIPNNPGAGENALEPIYIKDDDGYDIDTFLIPDHYKNYITKVLIPNGVLKNRIEKLAFDIKQVYRNEEFHVICLLKGSRGFFSALLKYLNRIHNYSSTESPKHLYVEHYVRVKIEIVSEDLSCLKDKHVLIVEDIIDTGKTLLKFCEYLKKFEVKTIAITCLFIKRTPLWNGFKADFVGFSIPDAFVVGYSLDYNEKFRDLDHLCLVNDEGIKKFRT 6bo7 B 2.856 BS02 YPG B 1 K77 I146 D148 T149 G150 T152 K176 F197 V198 L203 D204 R210 K79 I138 D140 T141 G142 T144 K168 F189 V190 L195 D196 R202 E144 D145 D148 F197 R210 E136 D137 D140 F189 R202 2.4.2.8 0000166,0000287,0004422,0005737,0005829,0006166,0006178,0016757,0032263,0032264,0046100,0046872,0052657 A5K7E9 29161011 303 HHHKIPNNPGAGENALEPIYIKDDDGYDIDTFLIPDHYKNYITKVLIPNGVLKNRIEKLAFDIKQVYRNEEFHVICLLKGSRGFFSALLKYLNRIHNYSSTESPKHLYVEHYVRVKIEIVSEDLSCLKDKHVLIVEDIIDTGKTLLKFCEYLKKFEVKTIAITCLFIKRTPLWNGFKADFVGFSIPDAFVVGYSLDYNEKFRDLDHLCLVNDEGIKKFRT 6bo7 C 2.856 BS02 YPG C 1 K77 R112 I146 D148 T149 G150 T152 K176 F197 V198 D204 R210 K77 R112 I137 D139 T140 G141 T143 K167 F188 V189 D195 R201 E144 D145 D148 F197 R210 E135 D136 D139 F188 R201 2.4.2.8 0000166,0000287,0004422,0005737,0005829,0006166,0006178,0016757,0032263,0032264,0046100,0046872,0052657 A5K7E9 29161011 303 HKIPNNPGAGENALEPIYIKDDDGYDIDTFLIPDHYKNYITKVLIPNGVLKNRIEKLAFDIKQVYRNEEFHVICLLKGSRGFFSALLKYLNRIHNYSSTESPKHLYVEHYVRVKSIEIVSEDLSCLKDKHVLIVEDIIDTGKTLLKFCEYLKKFEVKTIAITCLFIKRTPLWNGFKADFVGFSIPDAFVVGYSLDYNEKFRDLDHLCLVNDEGIKKFRT 6bo7 D 2.856 BS02 YPG D 1 K77 R112 I146 D148 T149 G150 T152 K176 F197 V198 L203 D204 R210 K76 R111 I136 D138 T139 G140 T142 K166 F187 V188 L193 D194 R200 E144 D145 D148 F197 R210 E134 D135 D138 F187 R200 2.4.2.8 0000166,0000287,0004422,0005737,0005829,0006166,0006178,0016757,0032263,0032264,0046100,0046872,0052657 A5K7E9 29161011 303 KIPNNPGAGENALEPIYIKDDDGYDIDTFLIPDHYKNYITKVLIPNGVLKNRIEKLAFDIKQVYRNEEFHVICLLKGSRGFFSALLKYLNRIHNYSSTESPKHLYVEHYVRVKSIEIVSEDLSCLKDKHVLIVEDIIDTGKTLLKFCEYLKKFEVKTIAITCLFIKRTPLWNGFKADFVGFSIPDAFVVGYSLDYNEKFRDLDHLCLVNDEGIKKFRT 6bo7 E 2.856 BS03 YPG E 1 K77 I146 D148 T149 G150 K151 T152 K176 F197 V198 D204 K76 I129 D131 T132 G133 K134 T135 K159 F180 V181 D187 E144 D145 D148 F197 R210 E127 D128 D131 F180 R193 2.4.2.8 0000166,0000287,0004422,0005737,0005829,0006166,0006178,0016757,0032263,0032264,0046100,0046872,0052657 A5K7E9 29161011 304 KIPNNPGAGENALEPIYIKDDDGYDIDTFLIPDHYKNYITKVLIPNGVLKNRIEKLAFDIKQVYRNEEFHVICLLKGSRGFFSALLKYLNRIHNYSSTESPKHLYVEHYVRVEDLSCLKDKHVLIVEDIIDTGKTLLKFCEYLKKFEVKTIAITCLFIKRTPLWNGFKADFVGFSIPDAFVVGYSLDYNEKFRDLDHLCLVNDEGIKKFRT 6bo7 F 2.856 BS02 YPG F 1 K77 I146 D148 T149 G150 T152 K176 F197 V198 K78 I138 D140 T141 G142 T144 K168 F189 V190 E144 D145 D148 F197 R210 E136 D137 D140 F189 R202 2.4.2.8 0000166,0000287,0004422,0005737,0005829,0006166,0006178,0016757,0032263,0032264,0046100,0046872,0052657 A5K7E9 29161011 303 HHKIPNNPGAGENALEPIYIKDDDGYDIDTFLIPDHYKNYITKVLIPNGVLKNRIEKLAFDIKQVYRNEEFHVICLLKGSRGFFSALLKYLNRIHNYSSTESPKHLYVEHYVRVKSIEIVSEDLSCLKDKHVLIVEDIIDTGKTLLKFCEYLKKFEVKTIAITCLFIKRTPLWNGFKADFVGFSIPDAFVVGYSLDYNEKFRDLDHLCLVNDEGIKKFRT 6bo7 G 2.856 BS02 YPG G 1 G78 R112 I146 D148 T149 G150 T152 K176 F197 V198 D204 R210 G77 R111 I136 D138 T139 G140 T142 K166 F187 V188 D194 R200 E144 D145 D148 F197 R210 E134 D135 D138 F187 R200 2.4.2.8 0000166,0000287,0004422,0005737,0005829,0006166,0006178,0016757,0032263,0032264,0046100,0046872,0052657 A5K7E9 29161011 303 KIPNNPGAGENALEPIYIKDDDGYDIDTFLIPDHYKNYITKVLIPNGVLKNRIEKLAFDIKQVYRNEEFHVICLLKGSRGFFSALLKYLNRIHNYSSTESPKHLYVEHYVRVKSIEIVSEDLSCLKDKHVLIVEDIIDTGKTLLKFCEYLKKFEVKTIAITCLFIKRTPLWNGFKADFVGFSIPDAFVVGYSLDYNEKFRDLDHLCLVNDEGIKKFRT 6bo7 H 2.856 BS02 YPG H 1 K77 G78 I146 D148 T149 G150 T152 K176 F197 V198 D204 R210 K76 G77 I136 D138 T139 G140 T142 K166 F187 V188 D194 R200 E144 D145 D148 F197 R210 E134 D135 D138 F187 R200 2.4.2.8 0000166,0000287,0004422,0005737,0005829,0006166,0006178,0016757,0032263,0032264,0046100,0046872,0052657 A5K7E9 29161011 303 KIPNNPGAGENALEPIYIKDDDGYDIDTFLIPDHYKNYITKVLIPNGVLKNRIEKLAFDIKQVYRNEEFHVICLLKGSRGFFSALLKYLNRIHNYSSTESPKHLYVEHYVRVKSIEIVSEDLSCLKDKHVLIVEDIIDTGKTLLKFCEYLKKFEVKTIAITCLFIKRTPLWNGFKADFVGFSIPDAFVVGYSLDYNEKFRDLDHLCLVNDEGIKKFRT 6bo7 I 2.856 BS02 YPG I 1 K77 R112 I146 D148 T149 G150 T152 K176 F197 V198 D204 R210 K76 R111 I135 D137 T138 G139 T141 K165 F186 V187 D193 R199 E144 D145 D148 F197 R210 E133 D134 D137 F186 R199 2.4.2.8 0000166,0000287,0004422,0005737,0005829,0006166,0006178,0016757,0032263,0032264,0046100,0046872,0052657 A5K7E9 29161011 303 KIPNNPGAGENALEPIYIKDDDGYDIDTFLIPDHYKNYITKVLIPNGVLKNRIEKLAFDIKQVYRNEEFHVICLLKGSRGFFSALLKYLNRIHNYSSTESPKHLYVEHYVRVKIEIVSEDLSCLKDKHVLIVEDIIDTGKTLLKFCEYLKKFEVKTIAITCLFIKRTPLWNGFKADFVGFSIPDAFVVGYSLDYNEKFRDLDHLCLVNDEGIKKFRT 6bo7 J 2.856 BS02 YPG J 1 I146 D148 T149 G150 T152 K176 F197 V198 D204 I136 D138 T139 G140 T142 K166 F187 V188 D194 E144 D145 D148 F197 R210 E134 D135 D138 F187 R200 2.4.2.8 0000166,0000287,0004422,0005737,0005829,0006166,0006178,0016757,0032263,0032264,0046100,0046872,0052657 A5K7E9 29161011 303 KIPNNPGAGENALEPIYIKDDDGYDIDTFLIPDHYKNYITKVLIPNGVLKNRIEKLAFDIKQVYRNEEFHVICLLKGSRGFFSALLKYLNRIHNYSSTESPKHLYVEHYVRVKSIEIVSEDLSCLKDKHVLIVEDIIDTGKTLLKFCEYLKKFEVKTIAITCLFIKRTPLWNGFKADFVGFSIPDAFVVGYSLDYNEKFRDLDHLCLVNDEGIKKFRT 6bo7 K 2.856 BS03 YPG K 1 K77 R112 I146 D148 T149 G150 K151 T152 K176 F197 V198 D204 R210 K76 R111 I135 D137 T138 G139 K140 T141 K165 F186 V187 D193 R199 E144 D145 D148 F197 R210 E133 D134 D137 F186 R199 2.4.2.8 0000166,0000287,0004422,0005737,0005829,0006166,0006178,0016757,0032263,0032264,0046100,0046872,0052657 A5K7E9 29161011 304 KIPNNPGAGENALEPIYIKDDDGYDIDTFLIPDHYKNYITKVLIPNGVLKNRIEKLAFDIKQVYRNEEFHVICLLKGSRGFFSALLKYLNRIHNYSSTESPKHLYVEHYVRVKIEIVSEDLSCLKDKHVLIVEDIIDTGKTLLKFCEYLKKFEVKTIAITCLFIKRTPLWNGFKADFVGFSIPDAFVVGYSLDYNEKFRDLDHLCLVNDEGIKKFRT 6bo7 L 2.856 BS03 YPG L 1 K77 G78 R112 I146 D148 T149 G150 T152 K176 F197 V198 D204 R210 K76 G77 R111 I134 D136 T137 G138 T140 K164 F185 V186 D192 R198 E144 D145 D148 F197 R210 E132 D133 D136 F185 R198 2.4.2.8 0000166,0000287,0004422,0005737,0005829,0006166,0006178,0016757,0032263,0032264,0046100,0046872,0052657 A5K7E9 29161011 304 KIPNNPGAGENALEPIYIKDDDGYDIDTFLIPDHYKNYITKVLIPNGVLKNRIEKLAFDIKQVYRNEEFHVICLLKGSRGFFSALLKYLNRIHNYSSTESPKHLYVEHYVRVIEIVSEDLSCLKDKHVLIVEDIIDTGKTLLKFCEYLKKFEVKTIAITCLFIKRTPLWNGFKADFVGFSIPDAFVVGYSLDYNEKFRDLDHLCLVNDEGIKKFRT