2yne A 1.72 BS02 YNE A 1 E97 F105 Y211 Y315 Y334 S335 N365 A366 L367 L388 L409 L410 E71 F79 Y185 Y289 Y308 S309 N339 A340 L341 L362 L383 L384 N161 F162 L163 T197 L410 N135 F136 L137 T171 L384 2.3.1.97 0004379,0005737,0006499,0016746,0018008,0046872 Ki=2.7nM -logKd/Ki=8.57, Ki=2.7nM A5K1A2 24451586 1001 DYKFWYTQPVPKINDEFNESVNEPFISDNKVEDVRKDEYKLPPGYSWYVCDVKDEKDRSEIYTLLTDNYVEDDDNIFRFNYSAEFLLWALTSPNYLKTWHIGVKYDASNKLIGFISAIPTDICIHKRTIKMAEVNFLCVHKTLRSKRLAPVLIKEITRRINLENIWQAIYTAGVYLPKPVSDARYYHRSINVKKLIEIGFSSLNSRLTMSRAIKLYRVEDTLNIKNMRLMKKKDVEGVHKLLGSYLEQFNLYAVFTKEEIAHWFLPIENVIYTYVNEENGKIKDMISFYSLPSQILGNDKYSTLNAAYSFYNVTTTATFKQLMQDAILLAKRNNFDVFNALEVMQNKSVFEDLKFGEGDGSLKYYLYNWKCASFAPAHVGIVLL 2yne B 1.72 BS02 YNE B 1 E97 F105 Y211 Y315 Y334 S335 N365 A366 L367 L388 L409 L410 E71 F79 Y185 Y289 Y308 S309 N339 A340 L341 L362 L383 L384 N161 F162 L163 T197 L410 N135 F136 L137 T171 L384 2.3.1.97 0004379,0005737,0006499,0016746,0018008,0046872 Ki=2.7nM A5K1A2 24451586 1001 DYKFWYTQPVPKINDEFNESVNEPFISDNKVEDVRKDEYKLPPGYSWYVCDVKDEKDRSEIYTLLTDNYVEDDDNIFRFNYSAEFLLWALTSPNYLKTWHIGVKYDASNKLIGFISAIPTDICIHKRTIKMAEVNFLCVHKTLRSKRLAPVLIKEITRRINLENIWQAIYTAGVYLPKPVSDARYYHRSINVKKLIEIGFSSLNSRLTMSRAIKLYRVEDTLNIKNMRLMKKKDVEGVHKLLGSYLEQFNLYAVFTKEEIAHWFLPIENVIYTYVNEENGKIKDMISFYSLPSQILGNDKYSTLNAAYSFYNVTTTATFKQLMQDAILLAKRNNFDVFNALEVMQNKSVFEDLKFGEGDGSLKYYLYNWKCASFAPAHVGIVLL 2yne C 1.72 BS02 YNE C 1 E97 D98 F105 Y211 Y315 Y334 S335 N365 A366 L367 L388 V408 L409 L410 E71 D72 F79 Y185 Y272 Y291 S292 N322 A323 L324 L345 V365 L366 L367 N161 F162 L163 T197 L410 N135 F136 L137 T171 L367 2.3.1.97 0004379,0005737,0006499,0016746,0018008,0046872 Ki=2.7nM A5K1A2 24451586 1001 DYKFWYTQPVPKINDEFNESVNEPFISDNKVEDVRKDEYKLPPGYSWYVCDVKDEKDRSEIYTLLTDNYVEDDDNIFRFNYSAEFLLWALTSPNYLKTWHIGVKYDASNKLIGFISAIPTDICIHKRTIKMAEVNFLCVHKTLRSKRLAPVLIKEITRRINLENIWQAIYTAGVYLPKPVSDARYYHRSINVKKLIEIGFVEDTLNIKNMRLMKKKDVEGVHKLLGSYLEQFNLYAVFTKEEIAHWFLPIENVIYTYVNEENGKIKDMISFYSLPSQILGNDKYSTLNAAYSFYNVTTTATFKQLMQDAILLAKRNNFDVFNALEVMQNKSVFEDLKFGEGDGSLKYYLYNWKCASFAPAHVGIVLL