5g21 A 1.5 BS03 YN4 A 1 V81 E82 D83 F88 F90 T203 Y217 F232 S330 L341 Y345 N376 L399 L421 V71 E72 D73 F78 F80 T193 Y207 F222 S320 L331 Y335 N366 L389 L411 N167 F168 L169 T203 L421 N157 F158 L159 T193 L411 2.3.1.97 0004379,0005737,0006499,0016746,0046872 Q4Q5S8 28626547 1002 AHAFWSTQPVPQTEDETEKIVFAGPMDEPKTVADIPEEPYPIASTFEWWTPNMEAADDIHAIYELLRDNYVEDDDSMFRFNYSEEFLQWALCPPNYIPDWHVAVRRKADKKLLAFIAGVPVTLRMGTPKYMKVKAQEKGEGEEAAKYDEPRHICEINFLCVHKQLREKRLAPILIKEATRRVNRTNVWQAVYTAGVLLPTPYASGQYFHRSLNPEKLVEIRFSGIPAQYQKFQNPMAMLKRNYQLPSAPKNSGLREMKPSDVPQVRRILMNYLDSFDVGPVFSDAEISHYLLPRDGVVFTYVVENDKKVTDFFSFYRIPSTVIGNSNYNLLNAAYVHYYAATSIPLHQLILDLLIVAHSRGFDVCNMVEILDNRSFVEQLKFGAGDGHLRYYFYNWAYPKIKPSQVALVML 5g22 A 2.32 BS02 YN4 A 1 E97 D98 F103 F105 Y211 H213 F226 S319 L330 Y334 L388 L410 E72 D73 F78 F80 Y186 H188 F201 S294 L305 Y309 L363 L385 N161 F162 L163 T197 L410 N136 F137 L138 T172 L385 2.3.1.97 0004379,0005737,0006499,0016746,0018008,0046872 Ki=0.1uM -logKd/Ki=7.00, Ki=0.1uM A5K1A2 28626547 1001 IDYKFWYTQPVPKINDEFNESVNEPFISDNKVEDVRKDEYKLPPGYSWYVCDVKDEKDRSEIYTLLTDNYVEDDDNIFRFNYSAEFLLWALTSPNYLKTWHIGVKYDASNKLIGFISAIPTDICIHKRTIKMAEVNFLCVHKTLRSKRLAPVLIKEITRRINLENIWQAIYTAGVYLPKPVSDARYYHRSINVKKLIEIGFSSLNSRLTMSRAIKLYRVEDTLNIKNMRLMKKKDVEGVHKLLGSYLEQFNLYAVFTKEEIAHWFLPIENVIYTYVNEENGKIKDMISFYSLPSQILGNDKYSTLNAAYSFYNVTTTATFKQLMQDAILLAKRNNFDVFNALEVMQNKSVFEDLKFGEGDGSLKYYLYNWKCASFAPAHVGIVLL 5g22 B 2.32 BS02 YN4 B 1 E97 D98 F103 F105 Y211 H213 F226 S319 Y334 L388 L410 E72 D73 F78 F80 Y186 H188 F201 S294 Y309 L363 L385 N161 F162 L163 T197 L410 N136 F137 L138 T172 L385 2.3.1.97 0004379,0005737,0006499,0016746,0018008,0046872 Ki=0.1uM A5K1A2 28626547 1001 IDYKFWYTQPVPKINDEFNESVNEPFISDNKVEDVRKDEYKLPPGYSWYVCDVKDEKDRSEIYTLLTDNYVEDDDNIFRFNYSAEFLLWALTSPNYLKTWHIGVKYDASNKLIGFISAIPTDICIHKRTIKMAEVNFLCVHKTLRSKRLAPVLIKEITRRINLENIWQAIYTAGVYLPKPVSDARYYHRSINVKKLIEIGFSSLNSRLTMSRAIKLYRVEDTLNIKNMRLMKKKDVEGVHKLLGSYLEQFNLYAVFTKEEIAHWFLPIENVIYTYVNEENGKIKDMISFYSLPSQILGNDKYSTLNAAYSFYNVTTTATFKQLMQDAILLAKRNNFDVFNALEVMQNKSVFEDLKFGEGDGSLKYYLYNWKCASFAPAHVGIVLL 5g22 C 2.32 BS02 YN4 C 1 E97 D98 F103 F105 G199 Y211 H213 F226 S319 Y334 N365 L388 L410 E71 D72 F77 F79 G173 Y185 H187 F200 S278 Y293 N324 L347 L369 N161 F162 L163 T197 L410 N135 F136 L137 T171 L369 2.3.1.97 0004379,0005737,0006499,0016746,0018008,0046872 Ki=0.1uM A5K1A2 28626547 1001 DYKFWYTQPVPKINDEFNESVNEPFISDNKVEDVRKDEYKLPPGYSWYVCDVKDEKDRSEIYTLLTDNYVEDDDNIFRFNYSAEFLLWALTSPNYLKTWHIGVKYDASNKLIGFISAIPTDICIHKRTIKMAEVNFLCVHKTLRSKRLAPVLIKEITRRINLENIWQAIYTAGVYLPKPVSDARYYHRSINVKKLIEIGFYRVEDTLNIKNMRLMKKKDVEGVHKLLGSYLEQFNLYAVFTKEEIAHWFLPIENVIYTYVNEENGKIKDMISFYSLPSQILGNDKYSTLNAAYSFYNVTTTATFKQLMQDAILLAKRNNFDVFNALEVMQNKSVFEDLKFGEGDGSLKYYLYNWKCASFAPAHVGIVLL