6p05 A 1.54 BS01 YF2 A 1 W81 P82 V87 D88 K91 L92 N140 D145 I146 M149 W40 P41 V46 D47 K50 L51 N99 D104 I105 M108 ? ic50=5.9nM Kd=<1.000000nM, IC50=5.9nM O60885 32453591 203 LENPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 7juo A 2.2 BS01 YF2 A 1 P1110 V1115 L1120 N1168 V1174 P27 V32 L37 N85 V91 2.3.1.-,2.3.1.48 0004402,0006355 Kd=<1.000000nM Q92793 35064087 1201 IFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSL 7juo A 2.2 BS02 YF2 B 1 L1119 L1120 L36 L37 2.3.1.-,2.3.1.48 0004402,0006355 Kd=<1.000000nM Q92793 35064087 1201 IFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSL 7juo B 2.2 BS01 YF2 A 1 L1119 L1120 L36 L37 2.3.1.-,2.3.1.48 0004402,0006355 Kd=<1.000000nM Q92793 35064087 1201 IFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSL 7juo B 2.2 BS02 YF2 B 1 P1110 Q1113 P1114 V1115 L1120 N1168 R1173 V1174 P27 Q30 P31 V32 L37 N85 R90 V91 2.3.1.-,2.3.1.48 0004402,0006355 Kd=<1.000000nM Q92793 35064087 1201 IFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSL 7juo C 2.2 BS01 YF2 D 1 L1119 L1120 L35 L36 2.3.1.-,2.3.1.48 0004402,0006355 Kd=<1.000000nM Q92793 35064087 1201 FKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSL 7juo C 2.2 BS02 YF2 C 1 P1110 Q1113 P1114 V1115 L1120 N1168 R1173 V1174 P26 Q29 P30 V31 L36 N84 R89 V90 2.3.1.-,2.3.1.48 0004402,0006355 Kd=<1.000000nM Q92793 35064087 1201 FKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSL 7juo D 2.2 BS01 YF2 D 1 P1110 P1114 V1115 L1120 N1168 R1173 V1174 P27 P31 V32 L37 N85 R90 V91 2.3.1.-,2.3.1.48 0004402,0006355 Kd=<1.000000nM Q92793 35064087 1201 IFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSL 7juo D 2.2 BS02 YF2 C 1 L1119 L1120 L36 L37 2.3.1.-,2.3.1.48 0004402,0006355 Kd=<1.000000nM Q92793 35064087 1201 IFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSL 7juo E 2.2 BS01 YF2 F 1 L1119 L1120 L36 L37 2.3.1.-,2.3.1.48 0004402,0006355 Kd=<1.000000nM Q92793 35064087 1201 IFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSL 7juo E 2.2 BS02 YF2 E 1 P1110 F1111 P1114 V1115 L1120 N1168 R1173 V1174 P27 F28 P31 V32 L37 N85 R90 V91 2.3.1.-,2.3.1.48 0004402,0006355 Kd=<1.000000nM Q92793 35064087 1201 IFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSL 7juo F 2.2 BS01 YF2 F 1 P1110 Q1113 P1114 V1115 L1120 N1168 R1173 V1174 P28 Q31 P32 V33 L38 N86 R91 V92 2.3.1.-,2.3.1.48 0004402,0006355 Kd=<1.000000nM Q92793 35064087 1201 KIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSL 7juo F 2.2 BS02 YF2 E 1 L1119 L1120 L37 L38 2.3.1.-,2.3.1.48 0004402,0006355 Kd=<1.000000nM Q92793 35064087 1201 KIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSL 7juo G 2.2 BS01 YF2 G 1 P1110 Q1113 P1114 V1115 L1120 N1168 R1173 V1174 P27 Q30 P31 V32 L37 N85 R90 V91 2.3.1.-,2.3.1.48 0004402,0006355 Kd=<1.000000nM Q92793 35064087 1201 IFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSL 7juo G 2.2 BS02 YF2 H 1 L1119 L1120 L36 L37 2.3.1.-,2.3.1.48 0004402,0006355 Kd=<1.000000nM Q92793 35064087 1201 IFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSL 7juo H 2.2 BS01 YF2 H 1 P1110 Q1113 P1114 V1115 L1120 N1168 V1174 P27 Q30 P31 V32 L37 N85 V91 2.3.1.-,2.3.1.48 0004402,0006355 Kd=<1.000000nM Q92793 35064087 1201 IFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSL