2ydj A 1.85 BS01 YDJ A 1 L15 Y20 A36 E85 Y86 C87 E134 N135 L137 D148 L8 Y13 A29 E70 Y71 C72 E119 N120 L122 D133 D130 K132 E134 N135 D148 T170 D115 K117 E119 N120 D133 T155 2.7.11.1 0000077,0004672,0004674,0005524,0006468 ic50=0.005uM -logKd/Ki=8.30, IC50=5nM IC50=6.0nM, EC50=10nM O14757 22551018 1270 DWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMNIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPL 2ydj B 1.85 BS01 YDJ B 1 L15 Y20 A36 E85 Y86 C87 G90 E134 N135 L137 D148 L7 Y12 A28 E69 Y70 C71 G74 E118 N119 L121 D132 D130 K132 E134 N135 D148 T170 D114 K116 E118 N119 D132 T154 2.7.11.1 0000077,0004672,0004674,0005524,0006468 ic50=0.005uM IC50=6.0nM, EC50=10nM O14757 22551018 1270 WDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMNIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPL 4w9w A 1.72 BS01 YDJ A 1 A77 Y132 C133 G136 N185 L187 C197 A39 Y94 C95 G98 N147 L149 C159 D180 K182 N185 D198 N208 T226 D142 K144 N147 D160 N170 T188 2.7.11.1 0004672,0005524,0006468 -logKd/Ki=7.48, Kd=33.1nM Q9NSY1 26853940 401 VGVRVFAVGRHQVTLEESLAEGGFSTVFLVRTHGGIRCALKRMYVNNMPDLNVCKREITIMKELSGHKNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPFGESQVAICDGNFTIPDNSRYSRNIHCLIRFMLEPDPEHRPDIFQVSYFAFKFAAADCPVSNINNSSIPSALPEPMTAS 4w9w A 1.72 BS02 YDJ A 2 N289 Y313 F314 F318 N251 Y275 F276 F280 D180 K182 N185 D198 N208 T226 D142 K144 N147 D160 N170 T188 2.7.11.1 0004672,0005524,0006468 -logKd/Ki=7.48, Kd=33.1nM Q9NSY1 26853940 402 VGVRVFAVGRHQVTLEESLAEGGFSTVFLVRTHGGIRCALKRMYVNNMPDLNVCKREITIMKELSGHKNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPFGESQVAICDGNFTIPDNSRYSRNIHCLIRFMLEPDPEHRPDIFQVSYFAFKFAAADCPVSNINNSSIPSALPEPMTAS 5wil A 2.2 BS01 YDJ A 1 L551 I559 L579 E627 F628 V629 G632 N678 L680 L16 I24 L44 E92 F93 V94 G97 N143 L145 N673 K677 N678 D699 N138 K142 N143 D164 2.7.10.2 0004672,0005524,0006468 O60674 30763067 901 VFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAAAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKAAELANLINNCMDYEPDHRPSFRAIIRDLNSLF 7cqe A 2.69 BS01 YDJ A 1 A617 F673 M674 K675 R727 N728 M730 D741 A38 F84 M85 K86 R138 N139 M141 D152 D723 R727 N728 D741 D134 R138 N139 D152 2.7.10.1 0004672,0004713,0005524,0006468 Q12866 33114206 906 EDVVIDRNLLILGKILGEGGSVMEGNLKQEDGTSLKVAVKTMKREIEEFLSEAACMKDFSHPNVIRLLGVCIEMIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESL 7cqe C 2.69 BS01 YDJ C 1 A617 F673 M674 R727 N728 M730 D741 A35 F70 M71 R124 N125 M127 D138 D723 R727 N728 D741 D120 R124 N125 D138 2.7.10.1 0004672,0004713,0005524,0006468 Q12866 33114206 902 EDVVIDRNLLILGKILGSVMEGNLKQEDGTSLKVAVKTFLSEAACMKDFSHPNVIRLLGVCIKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESL