4ci3 B 3.5 BS02 Y70 B 1 N353 P354 H355 H380 S381 W382 W388 W402 F404 N296 P297 H298 H323 S324 W325 W331 W345 F347 ? 0005634,0005737,0016567,0031464,0043161,0046872 -logKd/Ki=6.81, Kd=156.6nM P0CF65 25043012 1429 MINFDTSLPTSHMYLGSDMEEFHGRTLHDDDSCQVIPVLPHVMVMLIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVREREAHFGTTAEIYAYREEQEYGIETVKVKAIGRQRFKVLEIRTQSDGIQQAKVQILPERVLPSTMSAVQLQSLSRRHIRAFRQWWQKYQKRKFHCASLTSWPPWLYSLYDAETLMERVKRQLHEWDENLKDESLPTNPIDFSYRVAACLPIDDALRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQDTEITTKNEIFSLSLCGPMAAYVNPHGYIHETLTVYKACNLNLSGRPSTEHSWFPGYAWTIAQCRICGNHMGWKFTATKKDMSPQKFWGLTRSALLPR 4tzu A 2.0 BS02 Y70 A 1 H380 W382 W388 W402 F404 H44 W46 W52 W66 F68 ? Q8C7D2 504 TSLCCKQCQETEITTKNEIFSLSETLTVYKASNLNLIGRPSTVHSWFPGYAWTIAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLP 4tzu B 2.0 BS02 Y70 B 1 H380 S381 W382 W388 W402 F404 H44 S45 W46 W52 W66 F68 ? Q8C7D2 505 TSLCCKQCQETEITTKNEIFSLSETLTVYKASNLNLIGRPSTVHSWFPGYAWTIAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPT 4tzu C 2.0 BS02 Y70 C 1 H380 S381 W382 W388 W402 F404 H44 S45 W46 W52 W66 F68 ? Q8C7D2 504 TSLCCKQCQETEITTKNEIFSLSETLTVYKASNLNLIGRPSTVHSWFPGYAWTIAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLP 4tzu D 2.0 BS02 Y70 D 1 H380 S381 W382 W388 W402 F404 H44 S45 W46 W52 W66 F68 ? Q8C7D2 503 TSLCCKQCQETEITTKNEIFSLSETLTVYKASNLNLIGRPSTVHSWFPGYAWTIAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLP 4v2z A 1.45 BS02 Y70 A 1 N50 P51 F77 W79 W85 W99 Y101 N32 P33 F59 W61 W67 W81 Y83 ? 0046872 Ki=800nM A4TVL0 25448889 151 ASIFRCRQCGQTISRRDWLLPMGGDHEHVVFNPAGMIFRVWCFSLAQGLRLIGAPSGEFSWFKGYDWTIALCGQCGSHLGWHYEGGSQPQTFFGLIKDRLAEGPA 4v2z B 1.45 BS02 Y70 B 1 N50 P51 F77 S78 W79 W85 W99 Y101 N32 P33 F59 S60 W61 W67 W81 Y83 ? 0046872 Ki=800nM A4TVL0 25448889 151 ASIFRCRQCGQTISRRDWLLPMGGDHEHVVFNPAGMIFRVWCFSLAQGLRLIGAPSGEFSWFKGYDWTIALCGQCGSHLGWHYEGGSQPQTFFGLIKDRLAEGPA 4v2z C 1.45 BS02 Y70 C 1 N50 P51 F77 S78 W79 W85 W99 Y101 N27 P28 F54 S55 W56 W62 W76 Y78 ? 0046872 Ki=800nM A4TVL0 25448889 151 GASIFRCRQCGQTISRRDWLLEHVVFNPAGMIFRVWCFSLAQGLRLIGAPSGEFSWFKGYDWTIALCGQCGSHLGWHYEGGSQPQTFFGLIKDRLAEGPA 6h0f B 3.25 BS02 Y70 B 1 N351 P352 H353 E377 H378 W380 W386 W400 F402 N283 P284 H285 E309 H310 W312 W318 W332 F334 ? 0005515,0005634,0005737,0005829,0016020,0016567,0030177,0031333,0031334,0031464,0034766,0035641,0043161,0044325,0046872,0048471,1902607 IC50=2000nM Q96SW2 30385546 502 GRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 6h0f C 3.25 BS01 Y70 B 1 Q146 C147 N148 C150 G151 Q9 C10 N11 C13 G14 ? Q13422 30385546 502 GGRGERPFQCNQCGASFTQKGNLLRHIKLHSG 6h0f E 3.25 BS02 Y70 E 1 N351 P352 H353 E377 H378 W380 W386 W400 F402 N283 P284 H285 E309 H310 W312 W318 W332 F334 ? 0005515,0005634,0005737,0005829,0016020,0016567,0030177,0031333,0031334,0031464,0034766,0035641,0043161,0044325,0046872,0048471,1902607 IC50=2000nM Q96SW2 30385546 502 GRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 6h0f F 3.25 BS01 Y70 E 1 Q146 C147 C150 G151 Q9 C10 C13 G14 ? Q13422 30385546 502 GGRGERPFQCNQCGASFTQKGNLLRHIKLHSG 6h0f H 3.25 BS02 Y70 H 1 N351 P352 H353 E377 H378 W380 W386 W400 F402 N283 P284 H285 E309 H310 W312 W318 W332 F334 ? 0005515,0005634,0005737,0005829,0016020,0016567,0030177,0031333,0031334,0031464,0034766,0035641,0043161,0044325,0046872,0048471,1902607 IC50=2000nM Q96SW2 30385546 502 GRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 6h0f I 3.25 BS01 Y70 H 1 Q146 C147 C150 G151 Q9 C10 C13 G14 ? Q13422 30385546 502 GGRGERPFQCNQCGASFTQKGNLLRHIKLHSG 6h0f K 3.25 BS02 Y70 K 1 N351 P352 H353 E377 H378 W380 W386 W400 F402 N283 P284 H285 E309 H310 W312 W318 W332 F334 ? 0005515,0005634,0005737,0005829,0016020,0016567,0030177,0031333,0031334,0031464,0034766,0035641,0043161,0044325,0046872,0048471,1902607 IC50=2000nM Q96SW2 30385546 502 GRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 6h0f L 3.25 BS01 Y70 K 1 Q146 C147 N148 C150 G151 Q9 C10 N11 C13 G14 ? Q13422 30385546 502 GGRGERPFQCNQCGASFTQKGNLLRHIKLHSG 6h0g B 4.25 BS02 Y70 B 1 N351 P352 E377 H378 W380 W386 W400 F402 N310 P311 E336 H337 W339 W345 W359 F361 ? 0005515,0005634,0005737,0005829,0016020,0016567,0030177,0031333,0031334,0031464,0034766,0035641,0043161,0044325,0046872,0048471,1902607 IC50=2000nM Q96SW2 30385546 502 KKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 6h0g C 4.25 BS01 Y70 B 1 Q418 G423 Q6 G11 ? Q9BU19 30385546 502 GGRPLQCEICGFTCRQKASLNWHQRKHAET 6h0g E 4.25 BS02 Y70 E 1 N351 P352 H353 E377 H378 S379 W380 W386 F402 N310 P311 H312 E336 H337 S338 W339 W345 F361 ? 0005515,0005634,0005737,0005829,0016020,0016567,0030177,0031333,0031334,0031464,0034766,0035641,0043161,0044325,0046872,0048471,1902607 IC50=2000nM Q96SW2 30385546 502 KKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 6h0g F 4.25 BS01 Y70 E 1 E420 G423 E8 G11 ? Q9BU19 30385546 502 GGRPLQCEICGFTCRQKASLNWHQRKHAET 6uml C 3.58 BS03 Y70 C 1 N351 P352 H353 H378 W380 W386 W400 F402 N262 P263 H264 H289 W291 W297 W311 F313 ? 0005515,0005634,0005737,0005829,0016020,0016567,0030177,0031333,0031334,0031464,0034766,0035641,0043161,0044325,0046872,0048471,1902607 IC50=2000nM Q96SW2 32251415 502 NFDTSLPTSHTYLFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLYSEAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKQAKVQILPECVLPSTMSAVQLESLNKCQIFSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIP 8d81 B 3.9 BS02 Y70 B 1 H353 H378 S379 W380 W386 W400 H309 H334 S335 W336 W342 W356 ? 0005515,0005634,0005737,0005829,0016020,0016567,0030177,0031333,0031334,0031464,0034766,0035641,0043161,0044325,0046872,0048471,1902607 Q96SW2 36378961 502 NIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPT 8oiz B 2.5 BS02 Y70 B 1 N351 P352 H378 S379 W380 W386 W400 F402 N298 P299 H325 S326 W327 W333 W347 F349 ? 0005515,0005634,0005737,0005829,0016020,0016567,0030177,0031333,0031334,0031464,0034766,0035641,0043161,0044325,0046872,0048471,1902607 Q96SW2 37418539 502 PNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDILCL 8tnp B 3.3 BS02 Y70 B 1 N351 P352 W380 W386 W400 F402 N267 P268 W296 W302 W316 F318 ? 0005515,0005634,0005737,0005829,0016020,0016567,0030177,0031333,0031334,0031464,0034766,0035641,0043161,0044325,0046872,0048471,1902607 Q96SW2 38484051 502 SCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKSPQKFWGLTRSALLPTIP 8tnp C 3.3 BS01 Y70 B 1 C19 C22 G23 C3 C6 G7 ? 0005515,0006974,0008643,0015144,0015768,0016020,0030288,0034219,0034289,0042597,0042956,0043190,0055052,0055085,0060326,1901982,1990060 P0AEX9,Q13422 38484051 502 LFCPICGFTCRQKGNLLRHINLHTGEKLFKYHL 8u16 A 2.9 BS02 Y70 A 1 N351 P352 E377 H378 W380 W386 W400 F402 N270 P271 E296 H297 W299 W305 W319 F321 ? Q96SW2 38086859 502 LHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIP 8u16 C 2.9 BS01 Y70 A 1 C412 V414 C415 G416 C33 V35 C36 G37 ? Q9UJQ4 38086859 502 YKHKCKYCSKVFGTDSSLQIHLRSHTGERPFVCSVCGHRFTTKGNLKVHFHRH 8u16 D 2.9 BS02 Y70 D 1 N351 P352 H378 W380 W386 W400 F402 N270 P271 H297 W299 W305 W319 F321 ? Q96SW2 38086859 502 LHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIP 8u16 F 2.9 BS01 Y70 D 1 C412 V414 C415 G416 C33 V35 C36 G37 ? Q9UJQ4 38086859 502 YKHKCKYCSKVFGTDSSLQIHLRSHTGERPFVCSVCGHRFTTKGNLKVHFHRH 8u17 A 3.1 BS02 Y70 A 1 N351 P352 E377 H378 S379 W380 W386 N263 P264 E286 H287 S288 W289 W295 ? Q96SW2 38086859 502 LHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIP 8u17 C 3.1 BS01 Y70 A 1 V411 C412 V414 G416 V31 C32 V34 G36 ? Q9UJQ4 38086859 502 KHKCKYCSKVFGTDSSLQIHLRSHTGERPFVCSVCGHRFTTKGNLKVHFHRHPQ 8u17 D 3.1 BS02 Y70 D 1 N351 P352 H353 H378 W380 W386 W400 N272 P273 H274 H299 W301 W307 W321 ? Q96SW2 38086859 502 TLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPD 8u17 F 3.1 BS01 Y70 D 1 V411 C412 V414 G416 V31 C32 V34 G36 ? Q9UJQ4 38086859 502 KHKCKYCSKVFGTDSSLQIHLRSHTGERPFVCSVCGHRFTTKGNLKVHFHRHPQVK