4bc6 A 2.2 BS01 XZN A 1 L42 A63 A64 K65 I110 F112 C113 G116 E124 L164 D175 V314 L19 A40 A41 K42 I87 F89 C90 G93 E101 L141 D152 V283 D157 K159 G161 N162 D175 K184 D134 K136 G138 N139 D152 K161 2.7.11.1 0004672,0004674,0005524,0006468 O94804 1317 EHVRRDLDPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDHPYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSITSNKALRELVAEAKAEVME 5vc4 A 2.1 BS01 XZN A 1 E303 I305 K328 I374 N376 Y378 C379 G382 F433 D463 E11 I13 K36 I82 N84 Y86 C87 G90 F141 D153 D426 K428 D134 K136 2.7.10.2 0004672,0005524,0006468 Kd=43.7nM -logKd/Ki=7.36, Kd=43.7nM Kd=44nM P30291 28792760 601 SRYTTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIHSMSLVHMDIKPSNIFISRTKVMFKIGDLGHVTRISSPQVEEGDSRFLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPRNGDQWHEIRQGRLPRIPQVLSQEFTELLKVMIHPDPERRPSAMALVKHSVLLS 5vcz A 1.5 BS01 XZN A 1 L116 A137 K139 L185 T187 C190 G191 P192 Q196 F240 D251 L49 A70 K72 L118 T120 C123 G124 P125 Q129 F173 D184 D233 K235 N238 D251 D270 D166 K168 N171 D184 D203 2.7.11.1 0004672,0005524,0006468 Kd=444nM -logKd/Ki=6.35, Kd=444nM Kd=444nM Q99640 28792760 401 LGTENLYFQSQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQ