3ocb A 2.7 BS02 XM1 A 1 G162 K163 V164 A177 K179 M227 E228 A230 E234 E278 M281 T291 D292 F438 G19 K20 V21 A34 K36 M84 E85 A87 E91 E135 M138 T148 D149 F295 D274 K276 N279 D292 T312 D131 K133 N136 D149 T169 2.7.11.1 0004672,0004674,0005524,0006468 -logKd/Ki=8.30, IC50=5nM IC50=5nM P31749 20810279 1 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMRPHFPQFDYSASS 3ocb B 2.7 BS02 XM1 B 1 G159 G162 A177 K179 M227 E278 N279 M281 T291 D292 F438 G16 G19 A34 K36 M84 E135 N136 M138 T148 D149 F295 D274 K276 N279 D292 T312 D131 K133 N136 D149 T169 2.7.11.1 0004672,0004674,0005524,0006468 IC50=5nM P31749 20810279 2 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITRPHFPQFDYSASS