6nvh A 1.9 BS01 XL6 A 1 V481 R483 A501 K503 E520 M524 I534 V550 C552 A553 G556 L610 A620 D621 V26 R28 A46 K48 E65 M69 I79 V95 C97 A98 G101 L155 A165 D166 D603 R607 N608 D621 D148 R152 N153 D166 2.7.10.1 0004672,0004713,0005524,0006468 -logKd/Ki=7.95, IC50=11.1nM P22455 31413803 803 DLPLDPLWEFPRDRLVLGKPLGEGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAV 6nvl A 2.7 BS01 XL6 A 1 C488 V492 A512 K514 E531 M535 I545 V561 Y563 A564 N568 L630 A640 D641 F642 C26 V30 A50 K52 E69 M73 I83 V99 Y101 A102 N106 L154 A164 D165 F166 D623 R627 N628 D641 D147 R151 N152 D165 2.7.10.1 0004672,0004713,0005007,0005524,0006468 -logKd/Ki=7.95, IC50=11.1nM P11362 31413803 802 YELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLYYKKTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQE 6nvl B 2.7 BS01 XL6 B 1 V492 A512 K514 E531 I545 V561 Y563 A564 G567 N568 L630 A640 D641 F642 V25 A43 K45 E62 I76 V92 Y94 A95 G98 N99 L150 A160 D161 F162 D623 R627 N628 D641 D143 R147 N148 D161 2.7.10.1 0004672,0004713,0005007,0005524,0006468 P11362 31413803 802 SEYELPEDPRWELPRDRLVLGKPQVVLAEAIGLDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALT 6nvl C 2.7 BS01 XL6 C 1 L484 V492 A512 K514 E531 M535 V561 Y563 A564 L630 A640 D641 F642 L20 V23 A40 K42 E57 M61 V87 Y89 A90 L143 A153 D154 F155 D623 R627 N628 D641 D136 R140 N141 D154 2.7.10.1 0004672,0004713,0005007,0005524,0006468 P11362 31413803 801 LPEDPRWELPRDRLVLGKPLGQVVLAEAIGLDPNRVTKVAVKMLKSTEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLHHIDYYKKTPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALT 6nvl D 2.7 BS01 XL6 D 1 A512 K514 E531 M535 I545 V561 Y563 A564 S565 L630 A640 F642 A32 K34 E49 M53 I63 V77 Y79 A80 S81 L146 A156 F158 D623 R627 N628 D641 D139 R143 N144 D157 2.7.10.1 0004672,0004713,0005007,0005524,0006468 P11362 31413803 804 WELPRDRLVLGKQVVLAEAIGLDKPNRVTKVAVKMLKSTEKDLSDLISEMEMMKMIGKHKNIINLLGACTGPLYVIVEYASKGNLREYLQARRPPGLEYSYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTS