3c7q A 2.1 BS01 XIN A 1 L840 E850 V899 V916 F918 C919 K920 G922 L1035 C1045 L22 E32 V81 V98 F100 C101 K102 G104 L159 C169 D1028 A1030 R1032 N1033 D1046 K1055 D1064 D152 A154 R156 N157 D170 K175 D184 2.7.10.1 0004672,0004713,0004714,0005524,0006468,0007169 ic50=21nM -logKd/Ki=7.68, IC50=21nM IC50=21nM, Kd=2.9nM, Ki=3.80nM P35968 18559524 1172 RLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQD 5maf A 2.8 BS01 XIN A 1 I17 G18 V25 A38 K40 L86 Y88 C89 G92 L139 I149 D150 I17 G18 V25 A38 K40 L84 Y86 C87 G90 L137 I147 D148 D132 K134 E136 N137 D150 S171 D130 K132 E134 N135 D148 S155 2.7.10.2,2.7.11.1 0004672,0004674,0005524,0006468 Kd=4.9nM, Ki=5.6nM, IC50=43.0nM Q14680 29191878 403 PKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLDLPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKSLAYAAPELIQGKLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLLLAKKARGKPVRLR 5te0 A 1.9 BS01 XIN A 1 E50 L52 A53 A72 M94 V104 M126 D127 F128 C129 G132 Q133 N136 L183 E25 L27 A28 A47 M69 V79 M97 D98 F99 C100 G103 Q104 N107 L154 D176 K178 N181 D194 T222 D147 K149 N152 D165 T193 2.7.11.1 0004672,0005524,0006468 Kd=63nM Q2M2I8 401 MTSGLGSGYIGRVFGIGRQQVTVDEVLAEGGFAIVFLVRTSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFGESQVAICDGNFTIPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQVSYFSFKLLKKECPIPNVQNSPIPAKLPEPVKASEAAAK 6nec A 1.87 BS01 XIN A 1 L730 G731 V738 A756 K758 E775 I788 V804 E805 Y806 A807 G810 L881 D892 L18 G19 V26 A44 K46 E63 I76 V92 E93 Y94 A95 G98 L156 D167 D874 A876 R878 N879 D892 D149 A151 R153 N154 D167 2.7.10.1 0004672,0004713,0005524,0006468 Kd=31nM P07949 31118272 1101 EDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKR 6nec C 1.87 BS01 XIN C 1 K728 T729 L730 G731 V738 A756 K758 E775 I788 V804 E805 Y806 A807 G810 L881 S891 D892 K29 T30 L31 G32 V39 A57 K59 E76 I89 V105 E106 Y107 A108 G111 L162 S172 D173 D874 A876 R878 N879 D892 D155 A157 R159 N160 D173 2.7.10.1 0004672,0004713,0005524,0006468 Kd=31nM P07949 31118272 1102 GPLSLSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKR