1rsc A 2.3 BS01 XBP A 1 K175 E204 H294 R295 H327 K334 L335 S379 G380 G403 K167 E196 H286 R287 H319 K326 L327 S371 G372 G395 K175 K201 D202 D203 E204 H294 H327 K334 K167 K193 D194 D195 E196 H286 H319 K326 4.1.1.39 0000287,0004497,0005515,0009853,0015977,0015979,0016829,0016984,0019253,0031470,0046872 P00880 7922027 476 SAAGYKAGVKDYKLTYYTPDYTPKDTDLLAAFRFSPQPGVPADEAGAAIAAESSTGTWTTVWTDLLTDMDRYKGKCYHIEPVQGEENSYFAFIAYPLDLFEEGSVTNILTSIVGNVFGFKAIRSLRLEDIRFPVALVKTFQGPPHGIQVERDLLNKYGRPMLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENINSQPFQRWRDRFLFVADAIHKSQAETGEIKGHYLNVTAPTCEEMMKRAEFAKELGMPIIMHDFLTAGFTANTTLAKWCRDNGVLLHIHRAMHAVIDRQRNHGIHFRVLAKCLRLSGGDHLHSGTVVGKLEGDKASTLGFVDLMREDHIEADRSRGVFFTQDWASMPGVLPVASGGIHVWHMPALVEIFGDDSVLQFGGGTLGHPWGNAPGATANRVALEACVQARNEGRDLYREGGDILREAGKWSPELAAALDLWKEIKFEFETMDKL 1rsc A 2.3 BS02 XBP B 1 E60 T65 W66 N123 E52 T57 W58 N115 K175 K201 D202 D203 E204 H294 H327 K334 K167 K193 D194 D195 E196 H286 H319 K326 4.1.1.39 0000287,0004497,0005515,0009853,0015977,0015979,0016829,0016984,0019253,0031470,0046872 P00880 7922027 476 SAAGYKAGVKDYKLTYYTPDYTPKDTDLLAAFRFSPQPGVPADEAGAAIAAESSTGTWTTVWTDLLTDMDRYKGKCYHIEPVQGEENSYFAFIAYPLDLFEEGSVTNILTSIVGNVFGFKAIRSLRLEDIRFPVALVKTFQGPPHGIQVERDLLNKYGRPMLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENINSQPFQRWRDRFLFVADAIHKSQAETGEIKGHYLNVTAPTCEEMMKRAEFAKELGMPIIMHDFLTAGFTANTTLAKWCRDNGVLLHIHRAMHAVIDRQRNHGIHFRVLAKCLRLSGGDHLHSGTVVGKLEGDKASTLGFVDLMREDHIEADRSRGVFFTQDWASMPGVLPVASGGIHVWHMPALVEIFGDDSVLQFGGGTLGHPWGNAPGATANRVALEACVQARNEGRDLYREGGDILREAGKWSPELAAALDLWKEIKFEFETMDKL 1rsc B 2.3 BS01 XBP A 1 E60 T65 N123 E52 T57 N115 D203 E204 H294 H327 K334 D195 E196 H286 H319 K326 4.1.1.39 0000287,0004497,0005515,0009853,0015977,0015979,0016829,0016984,0019253,0031470,0046872 P00880 7922027 476 SAAGYKAGVKDYKLTYYTPDYTPKDTDLLAAFRFSPQPGVPADEAGAAIAAESSTGTWTTVWTDLLTDMDRYKGKCYHIEPVQGEENSYFAFIAYPLDLFEEGSVTNILTSIVGNVFGFKAIRSLRLEDIRFPVALVKTFQGPPHGIQVERDLLNKYGRPMLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENINSQPFQRWRDRFLFVADAIHKSQAETGEIKGHYLNVTAPTCEEMMKRAEFAKELGMPIIMHDFLTAGFTANTTLAKWCRDNGVLLHIHRAMHAVIDRQRNHGIHFRVLAKCLRLSGGDHLHSGTVVGKLEGDKASTLGFVDLMREDHIEADRSRGVFFTQDWASMPGVLPVASGGIHVWHMPALVEIFGDDSVLQFGGGTLGHPWGNAPGATANRVALEACVQARNEGRDLYREGGDILREAGKWSPELAAALDLWKEIKFEFETMDKL 1rsc B 2.3 BS02 XBP B 1 K175 E204 H294 R295 H327 K334 L335 S379 G380 G403 K167 E196 H286 R287 H319 K326 L327 S371 G372 G395 D203 E204 H294 H327 K334 D195 E196 H286 H319 K326 4.1.1.39 0000287,0004497,0005515,0009853,0015977,0015979,0016829,0016984,0019253,0031470,0046872 P00880 7922027 476 SAAGYKAGVKDYKLTYYTPDYTPKDTDLLAAFRFSPQPGVPADEAGAAIAAESSTGTWTTVWTDLLTDMDRYKGKCYHIEPVQGEENSYFAFIAYPLDLFEEGSVTNILTSIVGNVFGFKAIRSLRLEDIRFPVALVKTFQGPPHGIQVERDLLNKYGRPMLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENINSQPFQRWRDRFLFVADAIHKSQAETGEIKGHYLNVTAPTCEEMMKRAEFAKELGMPIIMHDFLTAGFTANTTLAKWCRDNGVLLHIHRAMHAVIDRQRNHGIHFRVLAKCLRLSGGDHLHSGTVVGKLEGDKASTLGFVDLMREDHIEADRSRGVFFTQDWASMPGVLPVASGGIHVWHMPALVEIFGDDSVLQFGGGTLGHPWGNAPGATANRVALEACVQARNEGRDLYREGGDILREAGKWSPELAAALDLWKEIKFEFETMDKL 1rsc C 2.3 BS01 XBP C 1 K175 E204 H294 R295 H327 K334 L335 S379 G380 G403 K167 E196 H286 R287 H319 K326 L327 S371 G372 G395 K175 K201 D202 D203 E204 H294 H327 K334 K167 K193 D194 D195 E196 H286 H319 K326 4.1.1.39 0000287,0004497,0005515,0009853,0015977,0015979,0016829,0016984,0019253,0031470,0046872 P00880 7922027 476 SAAGYKAGVKDYKLTYYTPDYTPKDTDLLAAFRFSPQPGVPADEAGAAIAAESSTGTWTTVWTDLLTDMDRYKGKCYHIEPVQGEENSYFAFIAYPLDLFEEGSVTNILTSIVGNVFGFKAIRSLRLEDIRFPVALVKTFQGPPHGIQVERDLLNKYGRPMLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENINSQPFQRWRDRFLFVADAIHKSQAETGEIKGHYLNVTAPTCEEMMKRAEFAKELGMPIIMHDFLTAGFTANTTLAKWCRDNGVLLHIHRAMHAVIDRQRNHGIHFRVLAKCLRLSGGDHLHSGTVVGKLEGDKASTLGFVDLMREDHIEADRSRGVFFTQDWASMPGVLPVASGGIHVWHMPALVEIFGDDSVLQFGGGTLGHPWGNAPGATANRVALEACVQARNEGRDLYREGGDILREAGKWSPELAAALDLWKEIKFEFETMDKL 1rsc C 2.3 BS02 XBP D 1 E60 T65 W66 N123 E52 T57 W58 N115 K175 K201 D202 D203 E204 H294 H327 K334 K167 K193 D194 D195 E196 H286 H319 K326 4.1.1.39 0000287,0004497,0005515,0009853,0015977,0015979,0016829,0016984,0019253,0031470,0046872 P00880 7922027 476 SAAGYKAGVKDYKLTYYTPDYTPKDTDLLAAFRFSPQPGVPADEAGAAIAAESSTGTWTTVWTDLLTDMDRYKGKCYHIEPVQGEENSYFAFIAYPLDLFEEGSVTNILTSIVGNVFGFKAIRSLRLEDIRFPVALVKTFQGPPHGIQVERDLLNKYGRPMLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENINSQPFQRWRDRFLFVADAIHKSQAETGEIKGHYLNVTAPTCEEMMKRAEFAKELGMPIIMHDFLTAGFTANTTLAKWCRDNGVLLHIHRAMHAVIDRQRNHGIHFRVLAKCLRLSGGDHLHSGTVVGKLEGDKASTLGFVDLMREDHIEADRSRGVFFTQDWASMPGVLPVASGGIHVWHMPALVEIFGDDSVLQFGGGTLGHPWGNAPGATANRVALEACVQARNEGRDLYREGGDILREAGKWSPELAAALDLWKEIKFEFETMDKL 1rsc D 2.3 BS01 XBP C 1 E60 T65 N123 E52 T57 N115 D203 E204 H294 H327 K334 D195 E196 H286 H319 K326 4.1.1.39 0000287,0004497,0005515,0009853,0015977,0015979,0016829,0016984,0019253,0031470,0046872 P00880 7922027 476 SAAGYKAGVKDYKLTYYTPDYTPKDTDLLAAFRFSPQPGVPADEAGAAIAAESSTGTWTTVWTDLLTDMDRYKGKCYHIEPVQGEENSYFAFIAYPLDLFEEGSVTNILTSIVGNVFGFKAIRSLRLEDIRFPVALVKTFQGPPHGIQVERDLLNKYGRPMLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENINSQPFQRWRDRFLFVADAIHKSQAETGEIKGHYLNVTAPTCEEMMKRAEFAKELGMPIIMHDFLTAGFTANTTLAKWCRDNGVLLHIHRAMHAVIDRQRNHGIHFRVLAKCLRLSGGDHLHSGTVVGKLEGDKASTLGFVDLMREDHIEADRSRGVFFTQDWASMPGVLPVASGGIHVWHMPALVEIFGDDSVLQFGGGTLGHPWGNAPGATANRVALEACVQARNEGRDLYREGGDILREAGKWSPELAAALDLWKEIKFEFETMDKL 1rsc D 2.3 BS02 XBP D 1 K175 E204 H294 R295 H327 K334 L335 S379 G380 G403 K167 E196 H286 R287 H319 K326 L327 S371 G372 G395 D203 E204 H294 H327 K334 D195 E196 H286 H319 K326 4.1.1.39 0000287,0004497,0005515,0009853,0015977,0015979,0016829,0016984,0019253,0031470,0046872 P00880 7922027 476 SAAGYKAGVKDYKLTYYTPDYTPKDTDLLAAFRFSPQPGVPADEAGAAIAAESSTGTWTTVWTDLLTDMDRYKGKCYHIEPVQGEENSYFAFIAYPLDLFEEGSVTNILTSIVGNVFGFKAIRSLRLEDIRFPVALVKTFQGPPHGIQVERDLLNKYGRPMLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENINSQPFQRWRDRFLFVADAIHKSQAETGEIKGHYLNVTAPTCEEMMKRAEFAKELGMPIIMHDFLTAGFTANTTLAKWCRDNGVLLHIHRAMHAVIDRQRNHGIHFRVLAKCLRLSGGDHLHSGTVVGKLEGDKASTLGFVDLMREDHIEADRSRGVFFTQDWASMPGVLPVASGGIHVWHMPALVEIFGDDSVLQFGGGTLGHPWGNAPGATANRVALEACVQARNEGRDLYREGGDILREAGKWSPELAAALDLWKEIKFEFETMDKL 1rsc E 2.3 BS01 XBP E 1 K175 E204 H294 R295 H327 K334 L335 S379 G380 G403 K167 E196 H286 R287 H319 K326 L327 S371 G372 G395 K175 K201 D202 D203 E204 H294 H327 K334 K167 K193 D194 D195 E196 H286 H319 K326 4.1.1.39 0000287,0004497,0005515,0009853,0015977,0015979,0016829,0016984,0019253,0031470,0046872 P00880 7922027 476 SAAGYKAGVKDYKLTYYTPDYTPKDTDLLAAFRFSPQPGVPADEAGAAIAAESSTGTWTTVWTDLLTDMDRYKGKCYHIEPVQGEENSYFAFIAYPLDLFEEGSVTNILTSIVGNVFGFKAIRSLRLEDIRFPVALVKTFQGPPHGIQVERDLLNKYGRPMLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENINSQPFQRWRDRFLFVADAIHKSQAETGEIKGHYLNVTAPTCEEMMKRAEFAKELGMPIIMHDFLTAGFTANTTLAKWCRDNGVLLHIHRAMHAVIDRQRNHGIHFRVLAKCLRLSGGDHLHSGTVVGKLEGDKASTLGFVDLMREDHIEADRSRGVFFTQDWASMPGVLPVASGGIHVWHMPALVEIFGDDSVLQFGGGTLGHPWGNAPGATANRVALEACVQARNEGRDLYREGGDILREAGKWSPELAAALDLWKEIKFEFETMDKL 1rsc E 2.3 BS02 XBP F 1 E60 T65 W66 N123 E52 T57 W58 N115 K175 K201 D202 D203 E204 H294 H327 K334 K167 K193 D194 D195 E196 H286 H319 K326 4.1.1.39 0000287,0004497,0005515,0009853,0015977,0015979,0016829,0016984,0019253,0031470,0046872 P00880 7922027 476 SAAGYKAGVKDYKLTYYTPDYTPKDTDLLAAFRFSPQPGVPADEAGAAIAAESSTGTWTTVWTDLLTDMDRYKGKCYHIEPVQGEENSYFAFIAYPLDLFEEGSVTNILTSIVGNVFGFKAIRSLRLEDIRFPVALVKTFQGPPHGIQVERDLLNKYGRPMLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENINSQPFQRWRDRFLFVADAIHKSQAETGEIKGHYLNVTAPTCEEMMKRAEFAKELGMPIIMHDFLTAGFTANTTLAKWCRDNGVLLHIHRAMHAVIDRQRNHGIHFRVLAKCLRLSGGDHLHSGTVVGKLEGDKASTLGFVDLMREDHIEADRSRGVFFTQDWASMPGVLPVASGGIHVWHMPALVEIFGDDSVLQFGGGTLGHPWGNAPGATANRVALEACVQARNEGRDLYREGGDILREAGKWSPELAAALDLWKEIKFEFETMDKL 1rsc F 2.3 BS01 XBP E 1 E60 T65 N123 E52 T57 N115 D203 E204 H294 H327 K334 D195 E196 H286 H319 K326 4.1.1.39 0000287,0004497,0005515,0009853,0015977,0015979,0016829,0016984,0019253,0031470,0046872 P00880 7922027 476 SAAGYKAGVKDYKLTYYTPDYTPKDTDLLAAFRFSPQPGVPADEAGAAIAAESSTGTWTTVWTDLLTDMDRYKGKCYHIEPVQGEENSYFAFIAYPLDLFEEGSVTNILTSIVGNVFGFKAIRSLRLEDIRFPVALVKTFQGPPHGIQVERDLLNKYGRPMLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENINSQPFQRWRDRFLFVADAIHKSQAETGEIKGHYLNVTAPTCEEMMKRAEFAKELGMPIIMHDFLTAGFTANTTLAKWCRDNGVLLHIHRAMHAVIDRQRNHGIHFRVLAKCLRLSGGDHLHSGTVVGKLEGDKASTLGFVDLMREDHIEADRSRGVFFTQDWASMPGVLPVASGGIHVWHMPALVEIFGDDSVLQFGGGTLGHPWGNAPGATANRVALEACVQARNEGRDLYREGGDILREAGKWSPELAAALDLWKEIKFEFETMDKL 1rsc F 2.3 BS02 XBP F 1 K175 E204 H294 R295 H327 K334 L335 S379 G380 G403 K167 E196 H286 R287 H319 K326 L327 S371 G372 G395 D203 E204 H294 H327 K334 D195 E196 H286 H319 K326 4.1.1.39 0000287,0004497,0005515,0009853,0015977,0015979,0016829,0016984,0019253,0031470,0046872 P00880 7922027 476 SAAGYKAGVKDYKLTYYTPDYTPKDTDLLAAFRFSPQPGVPADEAGAAIAAESSTGTWTTVWTDLLTDMDRYKGKCYHIEPVQGEENSYFAFIAYPLDLFEEGSVTNILTSIVGNVFGFKAIRSLRLEDIRFPVALVKTFQGPPHGIQVERDLLNKYGRPMLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENINSQPFQRWRDRFLFVADAIHKSQAETGEIKGHYLNVTAPTCEEMMKRAEFAKELGMPIIMHDFLTAGFTANTTLAKWCRDNGVLLHIHRAMHAVIDRQRNHGIHFRVLAKCLRLSGGDHLHSGTVVGKLEGDKASTLGFVDLMREDHIEADRSRGVFFTQDWASMPGVLPVASGGIHVWHMPALVEIFGDDSVLQFGGGTLGHPWGNAPGATANRVALEACVQARNEGRDLYREGGDILREAGKWSPELAAALDLWKEIKFEFETMDKL 1rsc G 2.3 BS01 XBP G 1 K175 E204 H294 R295 H327 K334 L335 S379 G380 G403 K167 E196 H286 R287 H319 K326 L327 S371 G372 G395 K175 K201 D202 D203 E204 H294 H327 K334 K167 K193 D194 D195 E196 H286 H319 K326 4.1.1.39 0000287,0004497,0005515,0009853,0015977,0015979,0016829,0016984,0019253,0031470,0046872 P00880 7922027 476 SAAGYKAGVKDYKLTYYTPDYTPKDTDLLAAFRFSPQPGVPADEAGAAIAAESSTGTWTTVWTDLLTDMDRYKGKCYHIEPVQGEENSYFAFIAYPLDLFEEGSVTNILTSIVGNVFGFKAIRSLRLEDIRFPVALVKTFQGPPHGIQVERDLLNKYGRPMLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENINSQPFQRWRDRFLFVADAIHKSQAETGEIKGHYLNVTAPTCEEMMKRAEFAKELGMPIIMHDFLTAGFTANTTLAKWCRDNGVLLHIHRAMHAVIDRQRNHGIHFRVLAKCLRLSGGDHLHSGTVVGKLEGDKASTLGFVDLMREDHIEADRSRGVFFTQDWASMPGVLPVASGGIHVWHMPALVEIFGDDSVLQFGGGTLGHPWGNAPGATANRVALEACVQARNEGRDLYREGGDILREAGKWSPELAAALDLWKEIKFEFETMDKL 1rsc G 2.3 BS02 XBP H 1 E60 T65 N123 E52 T57 N115 K175 K201 D202 D203 E204 H294 H327 K334 K167 K193 D194 D195 E196 H286 H319 K326 4.1.1.39 0000287,0004497,0005515,0009853,0015977,0015979,0016829,0016984,0019253,0031470,0046872 P00880 7922027 476 SAAGYKAGVKDYKLTYYTPDYTPKDTDLLAAFRFSPQPGVPADEAGAAIAAESSTGTWTTVWTDLLTDMDRYKGKCYHIEPVQGEENSYFAFIAYPLDLFEEGSVTNILTSIVGNVFGFKAIRSLRLEDIRFPVALVKTFQGPPHGIQVERDLLNKYGRPMLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENINSQPFQRWRDRFLFVADAIHKSQAETGEIKGHYLNVTAPTCEEMMKRAEFAKELGMPIIMHDFLTAGFTANTTLAKWCRDNGVLLHIHRAMHAVIDRQRNHGIHFRVLAKCLRLSGGDHLHSGTVVGKLEGDKASTLGFVDLMREDHIEADRSRGVFFTQDWASMPGVLPVASGGIHVWHMPALVEIFGDDSVLQFGGGTLGHPWGNAPGATANRVALEACVQARNEGRDLYREGGDILREAGKWSPELAAALDLWKEIKFEFETMDKL 1rsc H 2.3 BS01 XBP G 1 E60 T65 W66 N123 E52 T57 W58 N115 D203 E204 H294 H327 K334 D195 E196 H286 H319 K326 4.1.1.39 0000287,0004497,0005515,0009853,0015977,0015979,0016829,0016984,0019253,0031470,0046872 P00880 7922027 476 SAAGYKAGVKDYKLTYYTPDYTPKDTDLLAAFRFSPQPGVPADEAGAAIAAESSTGTWTTVWTDLLTDMDRYKGKCYHIEPVQGEENSYFAFIAYPLDLFEEGSVTNILTSIVGNVFGFKAIRSLRLEDIRFPVALVKTFQGPPHGIQVERDLLNKYGRPMLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENINSQPFQRWRDRFLFVADAIHKSQAETGEIKGHYLNVTAPTCEEMMKRAEFAKELGMPIIMHDFLTAGFTANTTLAKWCRDNGVLLHIHRAMHAVIDRQRNHGIHFRVLAKCLRLSGGDHLHSGTVVGKLEGDKASTLGFVDLMREDHIEADRSRGVFFTQDWASMPGVLPVASGGIHVWHMPALVEIFGDDSVLQFGGGTLGHPWGNAPGATANRVALEACVQARNEGRDLYREGGDILREAGKWSPELAAALDLWKEIKFEFETMDKL 1rsc H 2.3 BS02 XBP H 1 K175 E204 H294 R295 H327 K334 L335 S379 G380 G403 K167 E196 H286 R287 H319 K326 L327 S371 G372 G395 D203 E204 H294 H327 K334 D195 E196 H286 H319 K326 4.1.1.39 0000287,0004497,0005515,0009853,0015977,0015979,0016829,0016984,0019253,0031470,0046872 P00880 7922027 476 SAAGYKAGVKDYKLTYYTPDYTPKDTDLLAAFRFSPQPGVPADEAGAAIAAESSTGTWTTVWTDLLTDMDRYKGKCYHIEPVQGEENSYFAFIAYPLDLFEEGSVTNILTSIVGNVFGFKAIRSLRLEDIRFPVALVKTFQGPPHGIQVERDLLNKYGRPMLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENINSQPFQRWRDRFLFVADAIHKSQAETGEIKGHYLNVTAPTCEEMMKRAEFAKELGMPIIMHDFLTAGFTANTTLAKWCRDNGVLLHIHRAMHAVIDRQRNHGIHFRVLAKCLRLSGGDHLHSGTVVGKLEGDKASTLGFVDLMREDHIEADRSRGVFFTQDWASMPGVLPVASGGIHVWHMPALVEIFGDDSVLQFGGGTLGHPWGNAPGATANRVALEACVQARNEGRDLYREGGDILREAGKWSPELAAALDLWKEIKFEFETMDKL 4uat A 1.3 BS01 XBP A 1 D8 V9 N10 E17 H20 T49 G50 G51 R54 H75 K78 T115 T116 T117 S118 D8 V9 N10 E17 H20 T49 G50 G51 R54 H75 K78 T115 T116 T117 S118 D8 V9 N10 T16 T47 T115 T116 K151 E175 D176 D8 V9 N10 T16 T47 T115 T116 K151 E175 D176 3.1.3.- 0000287,0005998,0016787,0046872 -logKd/Ki=5.89, Ki~1.3uM P95649 27246049 301 MIEAILFDVNGTLAETEELHRRAFNETFAALGVDWFWDREEYRELLTTTGGKERIARFLRHQKGDPAPLPIADIHRAKTERFVALMAEGEIALRPGIADLIAEAKRAGIRLAVATTTSLPNVEALCRACFGHPAREIFDVIAAGDMVAEKKPSPDIYRLALRELDVPPERAVALEDSLNGLRAAKGAGLRCIVSPGFYTRHEEFAGADRLLDSFAELGGLAGLDL 4uat B 1.3 BS01 XBP B 1 D8 V9 N10 E17 H20 T49 G50 G51 R54 H75 K78 T115 T116 T117 S118 D8 V9 N10 E17 H20 T49 G50 G51 R54 H75 K78 T115 T116 T117 S118 D8 V9 N10 T16 T47 T115 T116 K151 E175 D176 D8 V9 N10 T16 T47 T115 T116 K151 E175 D176 3.1.3.- 0000287,0005998,0016787,0046872 P95649 27246049 301 MIEAILFDVNGTLAETEELHRRAFNETFAALGVDWFWDREEYRELLTTTGGKERIARFLRHQKGDPAPLPIADIHRAKTERFVALMAEGEIALRPGIADLIAEAKRAGIRLAVATTTSLPNVEALCRACFGHPAREIFDVIAAGDMVAEKKPSPDIYRLALRELDVPPERAVALEDSLNGLRAAKGAGLRCIVSPGFYTRHEEFAGADRLLDSFAELGGLAGLDL 4uau A 1.45 BS01 XBP A 1 D8 V9 N10 E17 H20 T49 G50 G51 R54 H75 K78 T115 T116 T117 S118 D8 V9 N10 E17 H20 T49 G50 G51 R54 H75 K78 T115 T116 T117 S118 D8 V9 N10 T16 T47 T115 T116 K151 E175 D176 D8 V9 N10 T16 T47 T115 T116 K151 E175 D176 3.1.3.- 0000287,0005998,0016787,0046872 -logKd/Ki=5.89, Ki~1.3uM P95649 27246049 301 MIEAILFDVNGTLAETEELHRRAFNETFAALGVDWFWDREEYRELLTTTGGKERIARFLRHQKGDPAPLPIADIHRAKTERFVALMAEGEIALRPGIADLIAEAKRAGIRLAVATTTSLPNVEALCRACFGHPAREIFDVIAAGDMVAEKKPSPDIYRLALRELDVPPERAVALEDSLNGLRAAKGAGLRCIVSPGFYTRHEEFAGADRLLDSFAELGGLAGLDLT 4uau B 1.45 BS01 XBP B 1 D8 V9 N10 E17 H20 T49 G50 G51 R54 H75 K78 T115 T116 T117 S118 D8 V9 N10 E17 H20 T49 G50 G51 R54 H75 K78 T115 T116 T117 S118 D8 V9 N10 T16 T47 T115 T116 K151 E175 D176 D8 V9 N10 T16 T47 T115 T116 K151 E175 D176 3.1.3.- 0000287,0005998,0016787,0046872 P95649 27246049 301 MIEAILFDVNGTLAETEELHRRAFNETFAALGVDWFWDREEYRELLTTTGGKERIARFLRHQKGDPAPLPIADIHRAKTERFVALMAEGEIALRPGIADLIAEAKRAGIRLAVATTTSLPNVEALCRACFGHPAREIFDVIAAGDMVAEKKPSPDIYRLALRELDVPPERAVALEDSLNGLRAAKGAGLRCIVSPGFYTRHEEFAGADRLLDSFAELGGLAGLDL