3kr8 A 2.1 BS02 XAV A 1 H1031 G1032 F1035 Y1050 Y1060 F1061 A1062 S1068 Y1071 I1075 E1138 H80 G81 F84 Y99 Y109 F110 A111 S117 Y120 I124 E183 2.4.2.-,2.4.2.30 0003950 Kd=8nM -logKd/Ki=8.10, Kd=8nM IC50=4nM, Kd=10nM Q9H2K2 20565110 1163 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 3kr8 C 2.1 BS02 XAV C 1 H1031 G1032 F1035 A1049 Y1050 Y1060 F1061 A1062 S1068 Y1071 I1075 E1138 H80 G81 F84 A98 Y99 Y109 F110 A111 S117 Y120 I124 E185 2.4.2.-,2.4.2.30 0003950 Kd=8nM IC50=4nM, Kd=10nM Q9H2K2 20565110 1163 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 3uh4 A 2.0 BS02 XAV A 1 H1184 G1185 S1186 P1187 F1188 Y1213 F1214 A1215 S1221 Y1224 H80 G81 S82 P83 F84 Y106 F107 A108 S114 Y117 2.4.2.-,2.4.2.30 0003950 ic50=0.011uM -logKd/Ki=7.96, IC50=0.011uM IC50=11nM, Kd=100nM O95271 22297980 1 GTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTIKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPEAP 3uh4 B 2.0 BS02 XAV B 1 H1184 G1185 P1187 Y1203 Y1213 F1214 A1215 K1220 S1221 Y1224 I1228 E1291 H80 G81 P83 Y99 Y109 F110 A111 K116 S117 Y120 I124 E187 2.4.2.-,2.4.2.30 0003950 ic50=0.011uM IC50=11nM, Kd=100nM O95271 22297980 1 GTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTIKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPEA 4r5w A 2.84 BS01 XAV A 1 D766 N767 H862 G863 Y896 F897 K903 S904 Y907 D106 N107 H200 G201 Y234 F235 K241 S242 Y245 S904 Y907 E988 S242 Y245 E326 2.4.2.-,2.4.2.30 0003950 -logKd/Ki=7.13, IC50=74.1nM IC50=120nM, Kd=620nM P09874 28001384 1106 MKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKAEMLDNLLDIEVAYSLLRGGSSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTAH 4r5w B 2.84 BS01 XAV B 1 D766 N767 H862 G863 Y896 F897 K903 S904 Y907 D106 N107 H200 G201 Y234 F235 K241 S242 Y245 S904 Y907 E988 S242 Y245 E326 2.4.2.-,2.4.2.30 0003950 IC50=120nM, Kd=620nM P09874 28001384 1103 MKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKAEMLDNLLDIEVAYSLLRGGSSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTAHHHHH