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BioLiP
Download all results in tab-seperated text for 6 receptor-ligand interactions, whose format is explained at readme.txt.
  • Hover over PDB to view the title of the structure. Click PDB to view the structure at the RCSB PDB database. Resolution -1.00 means the resolution is unavailable, e.g., for NMR structures.
  • Click Site # to view the binding site structure. Hover over Site # to view the binding residues.
  • Hover over Ligand to view the full ligand name. Click Ligand to view the 2D diagram and other detail information of the ligand.
  • Hover over EC number to view the full name of enzymatic activity.
  • Hover over GO terms to view all GO terms.
  • Hover over UniProt to view the protein name.

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    # PDB
    (Resolution Å)     		Site # Ligand EC number GO terms UniProt PubMed Binding
    affinity
    1 3kr8:A (2.1) BS02 XAV 2.4.2.-
    2.4.2.30    		 GO:0003950 ... Q9H2K2 20565110 MOAD: Kd=8nM
    PDBbind: -logKd/Ki=8.10, Kd=8nM
    BindingDB: IC50=4nM, Kd=10nM
    2 3kr8:C (2.1) BS02 XAV 2.4.2.-
    2.4.2.30    		 GO:0003950 ... Q9H2K2 20565110 MOAD: Kd=8nM
    BindingDB: IC50=4nM, Kd=10nM
    3 3uh4:A (2.0) BS02 XAV 2.4.2.-
    2.4.2.30    		 GO:0003950 ... O95271 22297980 MOAD: ic50=0.011uM
    PDBbind: -logKd/Ki=7.96, IC50=0.011uM
    BindingDB: IC50=11nM, Kd=100nM
    4 3uh4:B (2.0) BS02 XAV 2.4.2.-
    2.4.2.30    		 GO:0003950 ... O95271 22297980 MOAD: ic50=0.011uM
    BindingDB: IC50=11nM, Kd=100nM
    5 4r5w:A (2.84) BS01 XAV 2.4.2.-
    2.4.2.30    		 GO:0003950 ... P09874 28001384 PDBbind: -logKd/Ki=7.13, IC50=74.1nM
    BindingDB: IC50=120nM, Kd=620nM
    6 4r5w:B (2.84) BS01 XAV 2.4.2.-
    2.4.2.30    		 GO:0003950 ... P09874 28001384 BindingDB: IC50=120nM, Kd=620nM
    Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).

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