4url A 2.29 BS01 XAM A 1 I46 N49 E53 D76 R79 M81 H86 T92 I96 L100 H101 G103 T168 I29 N32 E36 D59 R62 M64 H69 T75 I79 L83 H84 G86 T137 0003677,0003918,0005524,0006265 ic50=500nM -logKd/Ki=6.30, IC50=500nM 24992706 2000 EGLEAVRKRPGMYIGSTDKRGLHHLVYEIVDNSVDEVLNGYGNEIDVTINKDGSISIEDNGRGMPTGIHKSGKPTVEVIFTVLHAGHGVGASVVNALSEWLEVEIHRDGNIYHQSFKNGGSPSSGLVKKGKTKKTGTKVTFKPDDTIFKASTSFNFDVLSERLQESAFLLKNLKITLNDLRSGKERQEHYHYEEGIKEFVSYVNEGKEVLHDVATFSGEANGIEVDVAFQYNDQYSESILSFVNNVRTKDGGTHEVGFKTAMTRVFNDYARRINELKTDKNLDGNDIREGLTAVVSVRIPEELLQFKSKLGTSEARSAVDSVVADKLPFYLEEKGQLSKSLVKKAIKAQQAREAARKAREDARS 4url B 2.29 BS01 XAM B 1 N49 E53 D76 R79 M81 H86 L100 H101 A102 G103 T168 N30 E34 D57 R60 M62 H67 L81 H82 A83 G84 T135 0003677,0003918,0005524,0006265 ic50=500nM 24992706 2000 LEAVRKRPGMYIGSTDKRGLHHLVYEIVDNSVDEVLNGYGNEIDVTINKDGSISIEDNGRGMPTGIHKSGKPTVEVIFTVLHAGGGVGASVVNALSEWLEVEIHRDGNIYHQSFKNGGSPSSGLVKKGKTKKTGTKVTFKPDDTIFKASTSFNFDVLSERLQESAFLLKNLKITLNDLRSGKERQEHYHYEEGIKEFVSYVNEGKEVLHDVATFSGEANGIEVDVAFQYNDQYSESILSFVNNVRTKDGGTHEVGFKTAMTRVFNDYARRINELKTKDKNLDGNDIREGLTAVVSVRIPEELLQFTKSKLGTSEARSAVDSVVADKLPFYLEEKGQLSKSLVKKAIKAQQAREAARKAREDAR 4urm A 2.94 BS01 XAM A 1 N54 E58 D81 R84 I86 Q91 K93 M94 H107 A108 G109 G110 T173 I175 N30 E34 D57 R60 I62 Q67 K69 M70 H83 A84 G85 G86 T136 I138 5.6.2.2 0003677,0003918,0005524,0006265 -logKd/Ki=8.05, IC50=9nM P0A0K8 24992706 2000 LEAARKRPGMYIGSTSERGLHHLVWEIVDNSIDEALAGYANQIEVVIEKDNWIKVTDNGRGIPVDIQEKMGRPAVEVILTVLHAGGKGVGSSVVNALSQDLEVYVHRNETIYHQAYKKGVPQFDLKEVGTTDKTGTVIRFKADGEIFTETTVYNYETLQQRIRELAFLNKGIQITLRDERDEENVREDSYHYEG 4urm B 2.94 BS01 XAM B 1 I51 N54 E58 D81 I86 Q91 K93 I102 H107 A108 G109 G110 T173 I27 N30 E34 D57 I62 Q67 K69 I78 H83 A84 G85 G86 T137 5.6.2.2 0003677,0003918,0005524,0006265 P0A0K8 24992706 2000 LEAARKRPGMYIGSTSERGLHHLVWEIVDNSIDEALAGYANQIEVVIEKDNWIKVTDNGRGIPVDIQEKMGRPAVEVILTVLHAGGKFGVGSSVVNALSQDLEVYVHRNETIYHQAYKKGVPQFDLKEVGTTDKTGTVIRFKADGEIFTETTVYNYETLQQRIRELAFLNKGIQITLRDERDEENVREDSYHYEG 4urm C 2.94 BS01 XAM B 1 R200 E201 F204 R160 E161 F164 5.6.2.2 0003677,0003918,0005524,0006265 P0A0K8 24992706 2000 LEAARKRPGMYIGSTSERGLHHLVWEIVDNSIDEALAGYANQIEVVIEKDNWIKVTDNGRGIPVDIQEKMGRPAVEVILTVLHAGVGSSVVNALSQDLEVYVHRNETIYHQAYKKGVPQFDLKEVGTTDKTGTVIRFKADGEIFTETTVYNYETLQQRIRELAFLNKGIQITLRDERDEENVREDSYHYEG 4urm C 2.94 BS02 XAM C 1 N54 E58 D81 G85 I86 P87 I102 H107 G109 T173 N30 E34 D57 G61 I62 P63 I78 H83 G85 T133 5.6.2.2 0003677,0003918,0005524,0006265 P0A0K8 24992706 2000 LEAARKRPGMYIGSTSERGLHHLVWEIVDNSIDEALAGYANQIEVVIEKDNWIKVTDNGRGIPVDIQEKMGRPAVEVILTVLHAGVGSSVVNALSQDLEVYVHRNETIYHQAYKKGVPQFDLKEVGTTDKTGTVIRFKADGEIFTETTVYNYETLQQRIRELAFLNKGIQITLRDERDEENVREDSYHYEG 4urm D 2.94 BS01 XAM D 1 N54 E58 D81 R84 I86 I102 V105 H107 A108 T173 I175 N29 E33 D56 R59 I61 I77 V80 H82 A83 T132 I134 5.6.2.2 0003677,0003918,0005524,0006265 P0A0K8 24992706 2000 EAARKRPGMYIGSTSERGLHHLVWEIVDNSIDEALAGYANQIEVVIEKDNWIKVTDNGRGIPVDIQEKMGRPAVEVILTVLHAGVGSSVVNALSQDLEVYVHRNETIYHQAYKKGVPQFDLKEVGTTDKTGTVIRFKADGEIFTETTVYNYETLQQRIRELAFLNKGIQITLRDERDEENVREDSYHYEG