1j37 A 2.4 BS02 X8Z A 1 Q265 H337 H367 E368 H371 E395 H497 Y504 Y507 Q243 H315 H345 E346 H349 E373 H475 Y482 Y485 H337 A338 H367 E368 H371 E395 H497 Y507 H315 A316 H345 E346 H349 E373 H475 Y485 3.4.15.1 0006508,0008237,0008241,0016020 Ki=1.1nM -logKd/Ki=8.96, Ki=1.1nM Q10714 12633854 801 IQAKEYLENLNKELAKRTNVETEAAWAYRSAITDENEKKKNEISAELAKFMKEVASDTTKFQWRSYQSEDLKRQFKALTKLGYAALPEDDYAELLDTLSAMESNFAKVKVCDYKDSTKCDLALDPEIEEVISKSRDHEELAYYWREFYDKAGTAVRSQFERYVELNTKAAKLNNFTSGAEAWLDEYEDDTFEQQLEDIFADIRPLYQQIHGYVRFRLRKHYGDAVVSETGPIPMHLLGNMWAQQWSEIADIVSPFPEKPLVDVSAEMEKQAYTPLKMFQMGDDFFTSMNLTKLPQDFWDKSIIEKPTDGRDLVCHASAWDFYLIDDVRIKQCTRVTQDQLFTVHHELGHIQYFLQYQHQPFVYRTGANPGFHEAVGDVLSLSVSTPKHLEKIGLLKDYVRDDEARINQLFLTALDKIVFLPFAFTMDKYRWSLFRGEVDKANWNCAFWKLRDEYSGIEPPVVRSEKDFDAPAKYHISADVEYLRYLVSFIIQFQFYKSACIKAGQYDPDNVELPLDNCDIYGSARAGAAFHNMLSMGASKPWPDALEAFNGERIMSGKAIAEYFEPLRVWLEAENIKNNVHIGWITSNKCVSSHHHHH 1j37 B 2.4 BS02 X8Z B 1 Q265 H337 H367 E368 H371 E395 H497 Y504 Y507 Q243 H315 H345 E346 H349 E373 H475 Y482 Y485 H337 A338 H367 E368 H371 E395 H497 Y507 H315 A316 H345 E346 H349 E373 H475 Y485 3.4.15.1 0006508,0008237,0008241,0016020 Ki=1.1nM Q10714 12633854 802 IQAKEYLENLNKELAKRTNVETEAAWAYRSAITDENEKKKNEISAELAKFMKEVASDTTKFQWRSYQSEDLKRQFKALTKLGYAALPEDDYAELLDTLSAMESNFAKVKVCDYKDSTKCDLALDPEIEEVISKSRDHEELAYYWREFYDKAGTAVRSQFERYVELNTKAAKLNNFTSGAEAWLDEYEDDTFEQQLEDIFADIRPLYQQIHGYVRFRLRKHYGDAVVSETGPIPMHLLGNMWAQQWSEIADIVSPFPEKPLVDVSAEMEKQAYTPLKMFQMGDDFFTSMNLTKLPQDFWDKSIIEKPTDGRDLVCHASAWDFYLIDDVRIKQCTRVTQDQLFTVHHELGHIQYFLQYQHQPFVYRTGANPGFHEAVGDVLSLSVSTPKHLEKIGLLKDYVRDDEARINQLFLTALDKIVFLPFAFTMDKYRWSLFRGEVDKANWNCAFWKLRDEYSGIEPPVVRSEKDFDAPAKYHISADVEYLRYLVSFIIQFQFYKSACIKAGQYDPDNVELPLDNCDIYGSARAGAAFHNMLSMGASKPWPDALEAFNGERIMSGKAIAEYFEPLRVWLEAENIKNNVHIGWITSNKCVSSHHHHH 2x8z A 1.98 BS01 X8Z A 1 Q265 H337 H367 E368 F441 K495 H497 Y504 Y507 Q249 H321 H351 E352 F425 K479 H481 Y488 Y491 H337 A338 H367 E368 H371 E395 H497 Y507 H321 A322 H351 E352 H355 E379 H481 Y491 3.4.15.1 0006508,0008237,0008241,0016020 Ki=11nM -logKd/Ki=7.96, Ki=11nM Q10714 20488190 1615 ALVKEEIQAKEYLENLNKELAKRTNVETEAAWAYGSNITDENEKKKNEISAELAKFMKEVASDTTKFQWRSYQSEDLKRQFKALTKLGYAALPEDDYAELLDTLSAMESNFAKVKVCDYKDSTKCDLALDPEIEEVISKSRDHEELAYYWREFYDKAGTAVRSQFERYVELNTKAAKLNNFTSGAEAWLDEYEDDTFEQQLEDIFADIRPLYQQIHGYVRFRLRKHYGDAVVSETGPIPMHLLGNMWAQQWSEIADIVSPFPEKPLVDVSAEMEKQGYTPLKMFQMGDDFFTSMNLTKLPQDFWDKSIIEKPTDGRDLVCHASAWDFYLTDDVRIKQCTRVTQDQLFTVHHELGHIQYFLQYQHQPFVYRTGANPGFHEAVGDVLSLSVSTPKHLEKIGLLKDYVRDDEARINQLFLTALDKIVFLPFAFTMDKYRWSLFRGEVDKANWNCAFWKLRDEYSGIEPPVVRSEKDFDAPAKYHISADVEYLRYLVSFIIQFQFYKSACIKAGQYDPDNVELPLDNCDIYGSAAAGAAFHNMLSMGASKPWPDALEAFNGERIMSGKAIAEYFEPLRVWLEAENIKNNVHIGWTTSNKCVS 3lus A 1.96 BS01 X8Z B 1 C61 N64 A65 P125 C60 N63 A64 P124 ? 0006979,0046872 Q9KKU4 1001 RNKNMSTIYQTSATASAGRNGVVSTEDKLLELNLSYPKEMGGSGTATNPEQLFAVGYAACFSNAILHVAREAKVALKEAPVTATVGIGPNGQGGFALSVALAAHIALEDEQARQLVTVAHQVCPYSNAVRGNIDVQVSVNGLAL 3lus B 1.96 BS01 X8Z B 1 Y37 P50 E51 F96 Y40 P53 E54 F99 ? 0006979,0046872 Q9KKU4 1001 SNAMRNKNMSTIYQTSATASAGRNGVVSTEDKLLELNLSYPKEMGGSGTATNPEQLFAVGYAACFSNAILHVAREAKVALKEAPVTATVGIGPNGQGGFALSVALAAHIALEDEQARQLVTVAHQVCPYSNAVRGNIDVQVSVNGLAL 4c1d A 1.198 BS01 X8Z A 1 F62 Y67 W87 H116 D118 H179 N210 F31 Y36 W56 H85 D87 H148 N179 H114 H116 D118 H179 C198 Y201 N210 H240 H83 H85 D87 H148 C167 Y170 N179 H209 3.5.2.6 0016787,0017001,0046872 -logKd/Ki=5.36, IC50=4.4uM Q9K2N0 26482303 350 EYPTVSEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEVEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSASVLYGGCAIYELSRTSAGNVADADLAEWPTSIERIQQHYPEAQFVIPGHGLPGGLDLLKHTTNVVKAHTNR 4c1d B 1.198 BS01 X8Z B 1 Y67 W87 H116 D118 H179 N210 Y36 W56 H85 D87 H148 N179 H114 H116 D118 H179 C198 Y201 N210 H240 H83 H85 D87 H148 C167 Y170 N179 H209 3.5.2.6 0016787,0017001,0046872 Q9K2N0 26482303 350 EYPTVSEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEVEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSASVLYGGCAIYELSRTSAGNVADADLAEWPTSIERIQQHYPEAQFVIPGHGLPGGLDLLKHTTNVVKAHTNR 4c1f A 2.01 BS01 X8Z A 1 W46 D99 H157 K179 H215 W26 D79 H137 K159 H195 H95 H97 D99 H157 C176 K179 N185 H215 H75 H77 D79 H137 C156 K159 N165 H195 3.5.2.6 0008270,0008800,0016787,0017001,0042597,0046677,0046872 -logKd/Ki=4.63, IC50=23.3uM P52699 26482303 300 SLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESK 4c1h A 1.1 BS01 X8Z A 1 W89 H118 D120 H179 C198 G209 N210 H240 W53 H82 D84 H143 C162 G173 N174 H204 H116 H118 D120 H179 C198 K201 N210 H240 H80 H82 D84 H143 C162 K165 N174 H204 3.5.2.6 0008270,0008800,0016787,0017001,0042597,0046677,0046872 -logKd/Ki=4.09, IC50=80.4uM P04190 26482303 305 TVIKNETGTISISQLNKNVWVHTELGSFNGEAVPSNGLVLNTSKGLVLVDSSWDDKLTKELIEMVEKKFQKRVTDVIITHAHADRIGGIKTLKERGIKAHSTALTAELAKKNGYEEPLGDLQTVTNLKFGNMKVETFYPGKGHTEDNIVVWLPQYNILVGGCLVKSTSAKDLGNVADAYVNEWSTSIENVLKRYRNINAVVPGHGEVGDKGLLLHTLDLLK 4c2p A 1.99 BS05 X8Z A 1 Q281 H353 A354 E384 K511 H513 Y520 Y523 Q242 H314 A315 E345 K468 H470 Y477 Y480 H353 A354 H383 E384 H387 E411 H513 Y523 H314 A315 H344 E345 H348 E372 H470 Y480 3.4.15.1 0006508,0008237,0008241,0016020 IC50=23nM, EC50=18540nM, Ki=2.0nM P12821 24297181 709 DEAEASKFVEEYDRTSQVVWNEYAEANWNYNTNITTETSKILLQKNMQIANHTLKYGTQARKFDVNQLQNTTIKRIIKKVQDLERAALPAQELEEYNKILLDMETTYSVATVCHPNGSCLQLEPDLTNVMATSRKYEDLLWAWEGWRDKAGRAILQFYPKYVELINQAARLNGYVDAGDSWRSMYETPSLEQDLERLFQELQPLYLNLHAYVRRALHRHYGAQHINLEGPIPAHLLGNMWAQTWSNIYDLVVPFPSAPSMDTTEAMLKQGWTPRRMFKEADDFFTSLGLLPVPPEFWNKSMLEKPTDGREVVCHASAWDFYNGKDFRIKQCTTVNLEDLVVAHHEMGHIQYFMQYKDLPVALREGANPGFHEAIGDVLALSVSTPKHLHSLNLLSSDEHDINFLMKMALDKIAFIPFSYLVDQWRWRVFDGSITKENYNQEWWSLRLKYQGLCPPVPRTQGDFDPGAKFHIPSSVPYIKYFVSFIIQFQFHEALCQAAGHTGPLHKCDIYQSKEAGQRLATAMKLGFSRPWPEAMQLITGQPNMSASAMLSYFKPLLDWLRTENELHGEKLGWPQYNWTPNS 4dpr A 2.02 BS02 X8Z A 1 Y267 G268 G269 H295 E318 Y378 Y383 R563 Y264 G265 G266 H292 E315 Y375 Y380 R560 E271 H295 E296 H299 E318 D375 Y383 E268 H292 E293 H296 E315 D372 Y380 3.3.2.6,3.4.11.4 0003723,0004177,0004301,0004463,0005515,0005576,0005634,0005654,0005737,0005829,0006508,0006629,0006691,0008233,0008237,0008270,0010043,0019370,0019538,0043171,0043434,0045148,0046872,0060509,0070006,0070062,1904724,1904813 Kd=6250nM, IC50=70nM, Ki=3700nM P09960 28827365 702 VDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDLTIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGETHPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAKEDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVTAMLVGKDLKVD 4exs A 2.4 BS01 X8Z A 1 W93 D124 H189 N220 H250 W60 D91 H156 N187 H217 H120 H122 D124 H189 C208 K211 N220 H250 H87 H89 D91 H156 C175 K178 N187 H217 3.5.2.6 Ki=39uM Kd=14000nM, IC50=50119nM C7C422 22713171 301 TIGQQMETGDQRFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLVVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQEGMVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLRLV 4exs B 2.4 BS01 X8Z B 1 V73 H122 D124 H189 N220 H250 V32 H81 D83 H148 N179 H209 H120 H122 D124 H189 C208 K211 N220 H250 H79 H81 D83 H148 C167 K170 N179 H209 3.5.2.6 Ki=39uM -logKd/Ki=4.41, Ki=39.0uM Kd=14000nM, IC50=50119nM C7C422 22713171 301 GDQRFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLVVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQEGMVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLRLV 4pqa A 1.78 BS01 X8Z A 1 D101 E135 E136 E164 G325 I349 D100 E134 E135 E163 G324 I348 3.5.1.18 0006526,0008270,0008777,0009014,0009085,0009089,0016787,0019877,0046872,0050897 -logKd/Ki=5.55, Ki=2.8uM Q9JYL2 26186504 401 TETQSLELAKELISRPSVTPDDRDCQKLLAERLHKIGFAAEELHFGDTKNIWLRRGTKAPVVCFAGHTDVVPTGPVEKWDSPPFEPAERDGRLYGRGAADMKTSIACFVTACERFVAKHPNHQGSIALLITSDEEGDALDGTTKVVDVLKARDELIDYCIVGEPTAVDKLGDMIKNGRRGSLSGNLTVKGKQGHIAYPHLAINPVHTFAPALLELTQEVWDEGNEYFPPTSFQISNINGGTGATNVIPGELNVKFNFRFSTESTEAGLKQRVHAILDKHGVQYDLQWSCSGQPFLTQAGKLTDVARAAIAETCGIEAELSTTGGTSDGRFIKAIAQELIELGPSNATIHQINENVRLNDIPKLSAVYEGILARLL 5aya A 2.02 BS03 X8Z A 1 H150 T177 H215 R252 H148 T175 H213 R250 H72 H74 D76 H77 H150 Y184 H215 H70 H72 D74 H75 H148 Y182 H213 3.5.2.6 0008800,0030655,0046872 G5ELM3 307 RDWSSPQQPFTIYGNTHYVGTGGISAVLLSSPQGHILVDGTTEKGAQVVAANIRAMGFKLSDVKYILSTHSHEDHAGGISAMQKLTGATVLAGAANVDTLRTGVSPKSDPQFGSLSNFPGSAKVRAVADGELVKLGPLAVKAHATPGHTEGGITWTWQSCEQGKCKDVVFADSLTAVSADSYRFSDHPEVVASLRGSFEAVEKLSCDIAIAAHPEVNDMWTRQQRAAKEGNSAYVDNGACRAIAAAGRKRLETRLASEK 5zio A 0.98 BS03 X8Z A 1 V46 H95 D97 H162 G192 N193 H223 V31 H80 D82 H147 G177 N178 H208 H93 H95 D97 H162 C181 K184 N193 H223 H78 H80 D82 H147 C166 K169 N178 H208 3.5.2.6 0008270,0008800,0016787,0017001,0042597,0046677,0046872 Kd=14000nM, IC50=50119nM C7C422 303 DQRFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLVVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQEGMVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLR 6u10 A 1.4 BS03 X8Z A 1 Y32 D109 I149 H181 P210 Y11 D88 I128 H160 P189 H105 H107 D109 H110 H181 Y212 H246 H84 H86 D88 H89 H160 Y191 H225 3.5.2.6 0008270,0008800,0017001 B2FTM1 303 AEAPLPQLRAYTVDASWLQPMAPLQVADHTWQIGTEDLTALLVQTAEGAVLLDGGMPQMAGHLLDNMKLRGVAPQDLRLILLSHAHADHAGPVAELKRRTGAHVAANAETAVLLARGGSNDLHFGDGITYPPASADRIIMDGEVVTVGGIAFTAHFMPGHTPGSTAWTWTDTRDGKPVRIAYADSLSAPGYQLKGNPRYPRLIEDYKRSFATVRALPCDLLLTPHPGASNWNYAVGSKASAEALTCNAYADAAEKKFDAQLARETAGTR 6u10 A 1.4 BS04 X8Z A 2 A136 R137 A115 R116 H105 H107 D109 H110 H181 Y212 H246 H84 H86 D88 H89 H160 Y191 H225 3.5.2.6 0008270,0008800,0017001 B2FTM1 305 AEAPLPQLRAYTVDASWLQPMAPLQVADHTWQIGTEDLTALLVQTAEGAVLLDGGMPQMAGHLLDNMKLRGVAPQDLRLILLSHAHADHAGPVAELKRRTGAHVAANAETAVLLARGGSNDLHFGDGITYPPASADRIIMDGEVVTVGGIAFTAHFMPGHTPGSTAWTWTDTRDGKPVRIAYADSLSAPGYQLKGNPRYPRLIEDYKRSFATVRALPCDLLLTPHPGASNWNYAVGSKASAEALTCNAYADAAEKKFDAQLARETAGTR 6v61 A 1.58 BS03 X8Z A 1 H118 D120 H180 N211 H241 H78 D80 H140 N171 H201 H116 H118 D120 H180 C199 R202 N211 H241 H76 H78 D80 H140 C159 R162 N171 H201 3.5.2.6 0008270,0008800,0017001 C6XID6 304 AEKPVEFVKLGTGVWMHTGYKVVPPWGNIRTNGLIIERGDYSVLVDTAWNDAQTAEIVAWAKDTLQKPIRASIHTHAHSDKMGGMDALHMLGVETFATDLTNRLAIERGLMPAKNVLNISEIGSQIEWEGLTILYPGGGHSEDNIVVNEGVNNILFGGCMIRPGMTTSLGNIDDANLGYWSKAVENAANAFPDSQIVIPSHGKPAGREILKNTAYITRP 8sko A 1.3 BS03 X8Z A 1 V73 H122 D124 H189 N220 H250 V33 H82 D84 H149 N180 H210 3.5.2.6 0008270,0008800,0016787,0017001,0042597,0046677,0046872 C7C422 37549809 303 GGDQRFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLVVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQEGLVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLR 8sko B 1.3 BS03 X8Z B 1 M67 F70 H122 D124 H189 G219 N220 H250 M27 F30 H82 D84 H149 G179 N180 H210 3.5.2.6 0008270,0008800,0016787,0017001,0042597,0046677,0046872 C7C422 37549809 303 GGDQRFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLVVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQEGLVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLR