3cm2 A 2.5 BS02 X23 A 1 L292 K297 V298 K299 G306 L307 T308 D309 W310 E314 W323 L40 K45 V46 K47 G54 L55 T56 D57 W58 E62 W71 2.3.2.27 Ki=340nM IC50=110nM P98170 18851976 600 STNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRT 3cm2 A 2.5 BS03 X23 G 1 H346 E349 H94 E97 2.3.2.27 Ki=340nM IC50=110nM P98170 18851976 600 STNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRT 3cm2 B 2.5 BS02 X23 B 1 L292 K297 G306 L307 T308 D309 W310 E314 L40 K45 G54 L55 T56 D57 W58 E62 2.3.2.27 Ki=340nM IC50=110nM P98170 18851976 600 STNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRT 3cm2 C 2.5 BS02 X23 C 1 L292 K297 V298 G306 L307 T308 D309 W310 E314 W323 L40 K45 V46 G54 L55 T56 D57 W58 E62 W71 2.3.2.27 Ki=340nM IC50=110nM P98170 18851976 600 STNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVR 3cm2 C 2.5 BS03 X23 F 1 H346 E349 H94 E97 2.3.2.27 Ki=340nM IC50=110nM P98170 18851976 600 STNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVR 3cm2 D 2.5 BS02 X23 D 1 L292 K297 V298 G306 L307 T308 D309 W310 E314 Q319 L39 K44 V45 G53 L54 T55 D56 W57 E61 Q66 2.3.2.27 Ki=340nM -logKd/Ki=6.47, Ki=340nM IC50=110nM P98170 18851976 600 TNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRT 3cm2 E 2.5 BS02 X23 E 1 L292 K297 G306 L307 T308 D309 W310 E314 W323 L39 K44 G53 L54 T55 D56 W57 E61 W70 2.3.2.27 Ki=340nM IC50=110nM P98170 18851976 600 TNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRT 3cm2 F 2.5 BS02 X23 F 1 L292 K297 G306 L307 T308 D309 W310 E314 W323 L40 K45 G54 L55 T56 D57 W58 E62 W71 2.3.2.27 Ki=340nM IC50=110nM P98170 18851976 600 STNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRT 3cm2 G 2.5 BS01 X23 C 1 H346 E349 H93 E96 2.3.2.27 Ki=340nM IC50=110nM P98170 18851976 600 TNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRT 3cm2 G 2.5 BS03 X23 G 1 L292 K297 G306 L307 T308 D309 W310 E314 W323 L39 K44 G53 L54 T55 D56 W57 E61 W70 2.3.2.27 Ki=340nM IC50=110nM P98170 18851976 600 TNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRT 3cm2 H 2.5 BS01 X23 D 1 E349 L352 E96 L99 2.3.2.27 Ki=340nM IC50=110nM P98170 18851976 600 TNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRT 3cm2 H 2.5 BS03 X23 H 1 L292 K297 G306 L307 T308 D309 W310 E314 Q319 L39 K44 G53 L54 T55 D56 W57 E61 Q66 2.3.2.27 Ki=340nM IC50=110nM P98170 18851976 600 TNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRT 3cm2 I 2.5 BS02 X23 I 1 L292 K297 G306 L307 T308 D309 W310 E314 W323 L39 K44 G53 L54 T55 D56 W57 E61 W70 2.3.2.27 Ki=340nM IC50=110nM P98170 18851976 600 TNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRT 3cm2 J 2.5 BS02 X23 J 1 K297 G306 L307 T308 D309 W310 E314 K44 G53 L54 T55 D56 W57 E61 2.3.2.27 Ki=340nM IC50=110nM P98170 18851976 600 TNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTT