3zki A 2.4 BS01 WZV A 1 G27 R28 G29 L46 D48 Y87 W131 I134 D241 G243 T244 T245 A347 G14 R15 G16 L33 D35 Y74 W118 I121 D220 G222 T223 T224 A315 D48 S51 N53 A55 Y87 D241 T244 D35 S38 N40 A42 Y74 D220 T223 3.4.23.45 0004190,0006508,0016020 -logKd/Ki=5.92, IC50=1.2uM Q9Y5Z0 23695257 1398 NFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIFSDGFWTGSQLACWTPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVP 3zki B 2.4 BS01 WZV B 1 G27 G29 L46 D48 Y87 W131 D241 G243 T245 A347 G12 G14 L31 D33 Y72 W116 D217 G219 T221 A311 D48 S51 N53 A55 Y87 D241 T244 D33 S36 N38 A40 Y72 D217 T220 3.4.23.45 0004190,0006508,0016020 Q9Y5Z0 23695257 1398 LAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGANGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASSDGFWTGSQLACWTTPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVP 3zkn A 2.0 BS01 WZV A 1 D48 Y87 Q89 N123 L126 I134 D241 D35 Y74 Q76 N110 L113 I121 D219 D48 S51 N53 A55 Y87 D241 T244 D35 S38 N40 A42 Y74 D219 T222 3.4.23.45 0004190,0006508,0016020 Q9Y5Z0 23695257 1398 NFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGANGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVP 3zkn B 2.0 BS01 WZV B 1 D48 Y87 Q89 N123 L126 I134 D241 D35 Y74 Q76 N110 L113 I121 D219 D48 S51 N53 A55 Y87 D241 T244 D35 S38 N40 A42 Y74 D219 T222 3.4.23.45 0004190,0006508,0016020 Q9Y5Z0 23695257 1398 NFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGANGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVP 3zks A 2.11 BS01 WZV A 1 G29 L46 D48 Y87 I134 D241 G243 T245 A347 G13 L30 D32 Y71 I118 D214 G216 T218 A310 D48 S51 N53 A55 Y87 D241 T244 D32 S35 N37 A39 Y71 D214 T217 3.4.23.45 0004190,0006508,0016020 Q9Y5Z0 23695257 1398 ANFLAMVDNLQGGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVP 3zov A 2.1 BS01 WZV A 1 G72 Q73 G74 Y75 L91 D93 Y132 F169 D289 G291 T293 A396 G16 Q17 G18 Y19 L35 D37 Y76 F113 D221 G223 T225 A321 D93 S96 N98 A100 Y132 D289 T292 D37 S40 N42 A44 Y76 D221 T224 3.4.23.46 0004190,0006508,0016020 -logKd/Ki=7.22, IC50=0.06uM P56817 23695257 1447 RGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGSVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVASIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYN