4qiy A 1.3 BS02 WWX A 1 N62 N67 I91 H94 H96 V135 L198 T199 T200 P202 N59 N64 I88 H91 H93 V131 L194 T195 T196 P198 H64 H94 H96 E106 H119 T199 H61 H91 H93 E103 H116 T195 4.2.1.1,4.2.1.69 0002009,0004064,0004089,0005515,0005737,0005829,0005886,0006730,0008270,0015670,0016829,0018820,0032230,0032849,0038166,0043209,0044070,0045177,0046872,0046903,0051453,0070050,0070062,2001150,2001225 Kd=50nM -logKd/Ki=7.30, Kd=50nM P00918 25758852 302 HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 4qiy B 1.3 BS02 WWX B 1 N62 N67 I91 H94 H96 F131 V135 L198 T199 T200 P202 N60 N65 I89 H92 H94 F128 V132 L195 T196 T197 P199 H64 H94 H96 E106 H119 T199 H62 H92 H94 E104 H117 T196 4.2.1.1,4.2.1.69 0002009,0004064,0004089,0005515,0005737,0005829,0005886,0006730,0008270,0015670,0016829,0018820,0032230,0032849,0038166,0043209,0044070,0045177,0046872,0046903,0051453,0070050,0070062,2001150,2001225 Kd=50nM P00918 25758852 302 HHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 4qiy C 1.3 BS02 WWX C 1 N62 N67 I91 H94 H96 V121 F131 V135 L198 T199 T200 P202 N60 N65 I89 H92 H94 V119 F128 V132 L195 T196 T197 P199 H64 H94 H96 E106 H119 T199 H62 H92 H94 E104 H117 T196 4.2.1.1,4.2.1.69 0002009,0004064,0004089,0005515,0005737,0005829,0005886,0006730,0008270,0015670,0016829,0018820,0032230,0032849,0038166,0043209,0044070,0045177,0046872,0046903,0051453,0070050,0070062,2001150,2001225 Kd=50nM P00918 25758852 302 HHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 4qiy D 1.3 BS02 WWX D 1 N62 N67 I91 H94 H96 V135 L198 T199 T200 P202 N60 N65 I89 H92 H94 V132 L195 T196 T197 P199 H64 H94 H96 E106 H119 T199 H62 H92 H94 E104 H117 T196 4.2.1.1,4.2.1.69 0002009,0004064,0004089,0005515,0005737,0005829,0005886,0006730,0008270,0015670,0016829,0018820,0032230,0032849,0038166,0043209,0044070,0045177,0046872,0046903,0051453,0070050,0070062,2001150,2001225 Kd=50nM P00918 25758852 302 HHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 4qiz A 1.55 BS02 WWX A 1 S64 N69 Q94 H96 H98 F133 L200 T201 V202 P204 S59 N64 Q89 H91 H93 F128 L195 T196 V197 P199 H66 H96 H98 E108 H121 T201 H61 H91 H93 E103 H116 T196 4.2.1.1 0004089,0005515,0005737,0005829,0006730,0008270,0016829,0043209,0043231,0046872 Kd=7.1nM -logKd/Ki=8.15, Kd=7.1nM Q8N1Q1 25758852 304 SWGYREHNGPIHWKEFFPIADGDQQSPIEIKTKEVKYDSSLRPLSIKYDPSSAKIISNSGHSFNVDFDDTENKSVLRGGPLTGSYRLRQVHLHWGSADDHGSEHIVDGVSYAAELHVVHWNSDKYPSFVEAAHEPDGLAVLGVFLQIGEPNSQLQKITDTLDSIKEKGKQTRFTNFDLLSLLPPSWDYWTYPGSLTVPPLLESVTWIVLKQPINISSQQLAKFRSLLCTAEGEAAAFLVSNHRPPQPLKGRKVRASFH 4qiz B 1.55 BS02 WWX B 1 S64 N69 Q94 H96 H98 V123 F133 L200 T201 V202 P204 S59 N64 Q89 H91 H93 V118 F128 L195 T196 V197 P199 H66 H96 H98 E108 H121 T201 H61 H91 H93 E103 H116 T196 4.2.1.1 0004089,0005515,0005737,0005829,0006730,0008270,0016829,0043209,0043231,0046872 Kd=7.1nM Q8N1Q1 25758852 303 SWGYREHNGPIHWKEFFPIADGDQQSPIEIKTKEVKYDSSLRPLSIKYDPSSAKIISNSGHSFNVDFDDTENKSVLRGGPLTGSYRLRQVHLHWGSADDHGSEHIVDGVSYAAELHVVHWNSDKYPSFVEAAHEPDGLAVLGVFLQIGEPNSQLQKITDTLDSIKEKGKQTRFTNFDLLSLLPPSWDYWTYPGSLTVPPLLESVTWIVLKQPINISSQQLAKFRSLLCTAEGEAAAFLVSNHRPPQPLKGRKVRASFH 4qj0 A 1.55 BS02 WWX A 1 N64 S67 H91 H117 V119 L197 T198 T199 N62 S65 H89 H115 V117 L195 T196 T197 H66 H91 H93 E104 H117 T198 H64 H89 H91 E102 H115 T196 4.2.1.1 0004089,0008270 Kd=48nM -logKd/Ki=7.32, Kd=48nM O43570 25758852 303 KWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFS 4qj0 B 1.55 BS02 WWX B 1 W4 N64 H66 T88 H91 H93 H117 V119 A129 S133 L139 L197 T198 T199 W2 N62 H64 T86 H89 H91 H115 V117 A127 S131 L137 L195 T196 T197 H66 H91 H93 E104 H117 T198 H64 H89 H91 E102 H115 T196 4.2.1.1 0004089,0008270 Kd=48nM O43570 25758852 303 KWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQ 4qj0 C 1.55 BS02 WWX C 1 W4 N64 Q89 H91 H93 H117 V119 A129 S133 L197 T198 T199 P200 W2 N62 Q87 H89 H91 H115 V117 A127 S131 L195 T196 T197 P198 H66 H91 H93 E104 H117 T198 H64 H89 H91 E102 H115 T196 4.2.1.1 0004089,0008270 Kd=48nM O43570 25758852 303 KWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFS 4qj0 D 1.55 BS02 WWX D 1 N64 S67 H91 H93 H117 V119 A129 L197 T198 T199 P200 W208 N62 S65 H89 H91 H115 V117 A127 L195 T196 T197 P198 W206 H66 H91 H93 E104 H117 T198 H64 H89 H91 E102 H115 T196 4.2.1.1 0004089,0008270 Kd=48nM O43570 25758852 305 KWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFS 6yh9 A 1.55 BS02 WWX A 1 N62 T91 H94 H96 H119 V121 S135 L141 L198 T199 T200 P202 N59 T88 H91 H93 H116 V118 S131 L137 L194 T195 T196 P198 H64 H94 H96 E106 H119 T199 H61 H91 H93 E103 H116 T195 4.2.1.1,4.2.1.69 0002009,0004064,0004089,0005515,0005737,0005829,0005886,0006730,0008270,0015670,0016829,0018820,0032230,0032849,0038166,0043209,0044070,0045177,0046872,0046903,0051453,0070050,0070062,2001150,2001225 P00918 33945229 302 HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHSFKVEFDDSQDKAVLKGGPLDGTYRLTQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDAGKASQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLNECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK