2ydw A 1.9 BS01 WSH A 1 W97 P98 V103 L108 L110 Y155 N156 I162 W22 P23 V28 L33 L35 Y80 N81 I87 ? Kd=46nM Kd=52nM, IC50=29.9nM P25440 21568322 1183 TNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASMPQ 2ydw B 1.9 BS01 WSH B 1 W97 P98 V103 L108 L110 Y155 N156 I162 W21 P22 V27 L32 L34 Y79 N80 I86 ? Kd=46nM -logKd/Ki=7.34, Kd=46.0nM Kd=52nM, IC50=29.9nM P25440 21568322 1182 NQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASMP 2ydw C 1.9 BS01 WSH C 1 W97 P98 V103 L110 Y155 N156 K157 W22 P23 V28 L35 Y80 N81 K82 ? Kd=46nM Kd=52nM, IC50=29.9nM P25440 21568322 1183 TNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASMPQ 2yel A 1.65 BS01 WSH A 1 W81 P82 L92 L94 N140 I146 W40 P41 L51 L53 N99 I105 ? ic50=15.5nM -logKd/Ki=7.28, Kd=52.5nM Kd=19nM, IC50=15.5nM O60885 21568322 1170 SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 2yem A 2.3 BS01 WSH A 1 W374 P375 L387 N433 V439 W26 P27 L39 N85 V91 ? ic50=15.5nM -logKd/Ki=7.81, IC50=15.5nM Kd=19nM, IC50=15.5nM O60885 21568322 1459 KVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMP 2yem B 2.3 BS01 WSH B 1 W374 P375 L387 N433 H437 V439 W26 P27 L39 N85 H89 V91 ? ic50=15.5nM Kd=19nM, IC50=15.5nM O60885 21568322 1460 KVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPD