2wp6 A 2.5 BS02 WP6 A 1 L17 E18 W21 Y110 M113 F114 L19 E20 W23 Y112 M115 F116 S14 L48 C52 C57 K60 G85 S86 F198 E202 I339 G459 H461 E466 E485 K486 S16 L50 C54 C59 K62 G87 S88 F200 E204 I341 G461 H463 E468 E487 K488 1.8.1.12 0000166,0004791,0005654,0005737,0015036,0015042,0016491,0016668,0020015,0045454,0046872,0050660,0097014,0098869 ic50=0.93uM Q389T8 21851087 1000 SHMSKAFDLVVIGAGSGGLEAGWNAATLYGKRVAVVDVQTSHGPPFYAALGGTCVNVGCVPKKLMVTGAQYMDHLRESAGFGWEFDGSSVKANWKKLIAAKNEAVLDINKSYEGMFNDTEGLDFFLGWGSLESKNVVVVRETADPKSAVKERLQADHILLATGSWPQMPAIPGIEHCISSNEAFYLPEPPRRVLTVGGGFISVEFAGIFNAYKPPGGKVTLCYRNNLILRGFDETIREEVTKQLTANGIEIMTNENPAKVSLNTDGSKHVTFESGKTLDVDVVMMAIGRIPRTNDLQLGNVGVKLTPKGGVQVDEFSRTNVPNIYAIGDITDRLMLTPVAINEGAALVDTVFGNKPRKTDHTRVASAVFSIPPIGTCGLIEEVAAKEFEKVAVYMSSFTPLMHNISGSKYKKFVAKIVTNHSDGTVLGVHLLGDGAPEIIQAVGVCLRLNAKISDFYNTIGVHPTSAEELCSMRTPSYYYVKGEKMEKLP 2wp6 B 2.5 BS02 WP6 B 1 S14 L17 E18 W21 G49 Y110 M113 F114 S13 L16 E17 W20 G48 Y109 M112 F113 S14 L48 C52 C57 K60 G85 S86 F198 E202 I339 G459 H461 E466 E485 K486 S13 L47 C51 C56 K59 G84 S85 F197 E201 I338 G458 H460 E465 E484 K485 1.8.1.12 0000166,0004791,0005654,0005737,0015036,0015042,0016491,0016668,0020015,0045454,0046872,0050660,0097014,0098869 ic50=0.93uM Q389T8 21851087 1000 SKAFDLVVIGAGSGGLEAGWNAATLYGKRVAVVDVQTSHGPPFYAALGGTCVNVGCVPKKLMVTGAQYMDHLRESAGFGWEFDGSSVKANWKKLIAAKNEAVLDINKSYEGMFNDTEGLDFFLGWGSLESKNVVVVRETADPKSAVKERLQADHILLATGSWPQMPAIPGIEHCISSNEAFYLPEPPRRVLTVGGGFISVEFAGIFNAYKPPGGKVTLCYRNNLILRGFDETIREEVTKQLTANGIEIMTNENPAKVSLNTDGSKHVTFESGKTLDVDVVMMAIGRIPRTNDLQLGNVGVKLTPKGGVQVDEFSRTNVPNIYAIGDITDRLMLTPVAINEGAALVDTVFGNKPRKTDHTRVASAVFSIPPIGTCGLIEEVAAKEFEKVAVYMSSFTPLMHNISGSKYKKFVAKIVTNHSDGTVLGVHLLGDGAPEIIQAVGVCLRLNAKISDFYNTIGVHPTSAEELCSMRTPSYYYVKGEKMEKLPD 2wp6 C 2.5 BS02 WP6 C 1 L17 E18 W21 G49 Y110 M113 L16 E17 W20 G48 Y109 M112 S14 L48 C52 C57 K60 G85 S86 F198 E202 I339 G459 H461 E466 E485 K486 S13 L47 C51 C56 K59 G84 S85 F197 E201 I338 G458 H460 E465 E484 K485 1.8.1.12 0000166,0004791,0005654,0005737,0015036,0015042,0016491,0016668,0020015,0045454,0046872,0050660,0097014,0098869 ic50=0.93uM Q389T8 21851087 1000 SKAFDLVVIGAGSGGLEAGWNAATLYGKRVAVVDVQTSHGPPFYAALGGTCVNVGCVPKKLMVTGAQYMDHLRESAGFGWEFDGSSVKANWKKLIAAKNEAVLDINKSYEGMFNDTEGLDFFLGWGSLESKNVVVVRETADPKSAVKERLQADHILLATGSWPQMPAIPGIEHCISSNEAFYLPEPPRRVLTVGGGFISVEFAGIFNAYKPPGGKVTLCYRNNLILRGFDETIREEVTKQLTANGIEIMTNENPAKVSLNTDGSKHVTFESGKTLDVDVVMMAIGRIPRTNDLQLGNVGVKLTPKGGVQVDEFSRTNVPNIYAIGDITDRLMLTPVAINEGAALVDTVFGNKPRKTDHTRVASAVFSIPPIGTCGLIEEVAAKEFEKVAVYMSSFTPLMHNISGSKYKKFVAKIVTNHSDGTVLGVHLLGDGAPEIIQAVGVCLRLNAKISDFYNTIGVHPTSAEELCSMRTPSYYYVKGEKMEKLPD 2wp6 D 2.5 BS02 WP6 D 1 L17 E18 W21 G49 Y110 M113 F114 L20 E21 W24 G52 Y113 M116 F117 S14 L48 C52 C57 K60 G85 S86 F198 E202 I339 G459 H461 E466 E485 K486 S17 L51 C55 C60 K63 G88 S89 F201 E205 I342 G462 H464 E469 E488 K489 1.8.1.12 0000166,0004791,0005654,0005737,0015036,0015042,0016491,0016668,0020015,0045454,0046872,0050660,0097014,0098869 ic50=0.93uM Q389T8 21851087 1000 GSHMSKAFDLVVIGAGSGGLEAGWNAATLYGKRVAVVDVQTSHGPPFYAALGGTCVNVGCVPKKLMVTGAQYMDHLRESAGFGWEFDGSSVKANWKKLIAAKNEAVLDINKSYEGMFNDTEGLDFFLGWGSLESKNVVVVRETADPKSAVKERLQADHILLATGSWPQMPAIPGIEHCISSNEAFYLPEPPRRVLTVGGGFISVEFAGIFNAYKPPGGKVTLCYRNNLILRGFDETIREEVTKQLTANGIEIMTNENPAKVSLNTDGSKHVTFESGKTLDVDVVMMAIGRIPRTNDLQLGNVGVKLTPKGGVQVDEFSRTNVPNIYAIGDITDRLMLTPVAINEGAALVDTVFGNKPRKTDHTRVASAVFSIPPIGTCGLIEEVAAKEFEKVAVYMSSFTPLMHNISGSKYKKFVAKIVTNHSDGTVLGVHLLGDGAPEIIQAVGVCLRLNAKISDFYNTIGVHPTSAEELCSMRTPSYYYVKGEKMEK