2f4j A 1.91 BS01 VX6 A 1 G249 Y253 V256 A269 T315 E316 F317 M318 T319 G321 L370 D381 G23 Y27 V30 A43 T89 E90 F91 M92 T93 G95 L144 D155 D363 A365 R367 N368 D381 P402 D137 A139 R141 N142 D155 P176 2.7.10.2 0004672,0004713,0005524,0006468 -logKd/Ki=5.66, IC50=2.2uM IC50=420nM, Kd=9.4nM, Ki=42nM P00519 16424036 514 GMSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAPAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKQ 2xyn A 2.81 BS01 VX6 A 1 L294 Y299 V302 A315 T361 E362 Y363 M364 P365 Y366 G367 L416 D427 L15 Y20 V23 A36 T80 E81 Y82 M83 P84 Y85 G86 L135 D146 D409 A411 R413 N414 D427 P448 D128 A130 R132 N133 D146 P167 2.7.10.2 0004672,0004713,0005524,0006468 -logKd/Ki=8.40, Kd=4nM Kd=4nM P42684 21417343 547 KWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHD 2xyn B 2.81 BS01 VX6 B 1 L294 Y299 M336 E362 Y363 M364 P365 G367 L416 D427 L15 Y20 M55 E81 Y82 M83 P84 G86 L135 D146 D409 A411 R413 N414 D427 P448 D128 A130 R132 N133 D146 P167 2.7.10.2 0004672,0004713,0005524,0006468 Kd=4nM P42684 21417343 547 KWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHD 2xyn B 2.81 BS02 VX6 B 2 T352 L353 P355 F357 T71 L72 P74 F76 D409 A411 R413 N414 D427 P448 D128 A130 R132 N133 D146 P167 2.7.10.2 0004672,0004713,0005524,0006468 Kd=4nM P42684 21417343 548 KWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHD 2xyn B 2.81 BS03 VX6 B 3 D437 T438 Y459 T461 S463 K465 P526 A527 D156 T157 Y178 T180 S182 K184 P245 A246 D409 A411 R413 N414 D427 P448 D128 A130 R132 N133 D146 P167 2.7.10.2 0004672,0004713,0005524,0006468 Kd=4nM P42684 21417343 549 KWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHD 2xyn C 2.81 BS01 VX6 C 1 L294 Y299 V302 A315 K317 T361 Y363 M364 P365 Y366 G367 L416 D427 L14 Y19 V22 A35 K37 T79 Y81 M82 P83 Y84 G85 L134 D145 D409 A411 R413 N414 D427 P448 D127 A129 R131 N132 D145 P166 2.7.10.2 0004672,0004713,0005524,0006468 Kd=4nM P42684 21417343 547 WEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFH 2xyn C 2.81 BS02 VX6 C 2 L353 P355 L71 P73 D409 A411 R413 N414 D427 P448 D127 A129 R131 N132 D145 P166 2.7.10.2 0004672,0004713,0005524,0006468 Kd=4nM P42684 21417343 548 WEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFH 2xyn C 2.81 BS03 VX6 C 3 K446 I449 S492 Y495 K164 I167 S210 Y213 D409 A411 R413 N414 D427 P448 D127 A129 R131 N132 D145 P166 2.7.10.2 0004672,0004713,0005524,0006468 Kd=4nM P42684 21417343 549 WEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFH 3amb A 2.25 BS02 VX6 A 1 V57 A70 K72 Y122 A123 P124 G126 L173 D184 N326 V55 A68 K70 Y120 A121 P122 G124 L171 D182 N319 D166 K168 E170 N171 D184 T201 D164 K166 E168 N169 D182 T199 2.7.11.11 0000287,0001669,0001707,0001843,0002027,0003091,0004672,0004674,0004679,0004691,0004712,0005515,0005524,0005634,0005654,0005737,0005739,0005759,0005813,0005829,0005886,0005930,0005952,0006397,0006468,0006611,0007189,0007193,0010737,0010881,0016241,0016310,0016607,0018105,0019221,0019901,0019904,0030145,0031410,0031514,0031594,0031625,0032024,0032703,0034237,0034380,0034605,0034704,0035694,0036126,0044853,0045542,0045667,0045722,0045879,0046827,0048240,0048471,0050804,0050850,0051726,0055117,0061136,0070062,0070417,0070613,0071333,0071374,0071377,0071872,0086064,0097546,0098794,0098978,0099103,0099170,0106310,1903779,1904262,1904539,1990044,2000810 Ki=0.66uM -logKd/Ki=6.18, Ki=0.66uM Kd=>10000nM P17612 21774789 351 AAAAKKGSEQESVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIRTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRIQQAVNFPFLVKLEFSFKDNSNLYMVLEYAPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIKVADFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKSNFDDYEEEEIRVSINEKCGKEFSEF 3e5a A 2.3 BS01 VX6 A 1 L139 F144 A160 E211 Y212 A213 P214 G216 T217 L263 A273 D274 L15 F20 A36 E87 Y88 A89 P90 G92 T93 L139 A149 D150 D256 K258 E260 N261 D274 T292 D132 K134 E136 N137 D150 T168 2.7.11.1 0000212,0000226,0000278,0004672,0005524,0006468,0007052,0007098,0007100,0051321 Ki=5.9nM -logKd/Ki=8.23, Ki=5.9nM Ki=0.600000nM, IC50=20nM, Kd=4.1nM O14965 18662907 500 KRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSK 4af3 A 2.75 BS01 VX6 A 1 L83 F88 V91 A104 K106 E155 Y156 A157 P158 G160 L207 L14 F19 V22 A35 K37 E86 Y87 A88 P89 G91 L138 D200 K202 E204 N205 D218 D131 K133 E135 N136 D149 2.7.11.1 0004672,0005524,0006468 -logKd/Ki=7.51, IC50=31nM Ki=18nM, IC50=30nM, Kd=7.4nM Q96GD4 22920039 500 RHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPTGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPS 4b8m A 1.85 BS01 VX6 A 1 L99 V107 A120 K122 E171 F172 A173 P174 G176 E177 L223 A233 L13 V21 A34 K36 E85 F86 A87 P88 G90 E91 L137 A147 D216 K218 E220 N221 D234 T252 D130 K132 E134 N135 D148 T166 2.7.11.1 0004672,0005524,0006468 IC50=19nM Q6DE08 1359 KFTIDDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREIEIQSHLRHPNILRMYNYFHDRKRIYLMLEFAPRGELYKELQKHGRFDEQRSATFMEELADALHYCHERKVIHRDIKPENLLMGYKGELKIADFGWSVHAPSLRRRTMCGTLDYLPPEMIEGKTHDEKVDLWCAGVLCYEFLVGMPPFDSPSHTETHRRIVNVDLKFPPFLSDGSKDLISKLLRYHPPQRLPLKGVMEHPWVKANSRRVLPPVYQS 4b8m B 1.85 BS01 VX6 B 1 L99 F104 E171 F172 A173 P174 G176 E177 L223 D234 L22 F27 E94 F95 A96 P97 G99 E100 L146 D157 D216 K218 E220 N221 D234 T252 D139 K141 E143 N144 D157 T175 2.7.11.1 0004672,0005524,0006468 IC50=19nM Q6DE08 1359 TALAEMPKRKFTIDDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREIEIQSHLRHPNILRMYNYFHDRKRIYLMLEFAPRGELYKELQKHGRFDEQRSATFMEELADALHYCHERKVIHRDIKPENLLMGYKGELKIADFGWSVHAPSLRRRTMCGTLDYLPPEMIEGKTHDEKVDLWCAGVLCYEFLVGMPPFDSPSHTETHRRIVNVDLKFPPFLSDGSKDLISKLLRYHPPQRLPLKGVMEHPWVKANSRRVLPPVYQS 4jbq A 2.3 BS01 VX6 A 1 L139 V147 A160 K162 E211 Y212 A213 P214 G216 L263 A273 L14 V22 A35 K37 E86 Y87 A88 P89 G91 L138 A148 D256 K258 E260 N261 D274 T292 D131 K133 E135 N136 D149 T158 2.7.11.1 0000212,0000226,0000278,0004672,0005524,0006468,0007052,0007098,0007100,0051321 Ki=0.600000nM, IC50=20nM, Kd=4.1nM O14965 23610398 501 RQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPS 4zog A 2.3 BS01 VX6 A 1 L248 Y253 V256 A269 K271 E316 F317 M318 T319 G321 L370 F382 L16 Y21 V24 A37 K39 E84 F85 M86 T87 G89 L138 F150 D363 A365 R367 N368 D381 P402 D131 A133 R135 N136 D149 P170 2.7.10.2 0004672,0004713,0005524,0006468 IC50=420nM, Kd=9.4nM, Ki=42nM P00519 601 DKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESS 4zog B 2.3 BS01 VX6 B 1 L248 Y253 V256 A269 E316 F317 M318 T319 G321 L370 L15 Y20 V23 A36 E83 F84 M85 T86 G88 L137 D363 A365 R367 N368 D381 P402 D130 A132 R134 N135 D148 P167 2.7.10.2 0004672,0004713,0005524,0006468 IC50=420nM, Kd=9.4nM, Ki=42nM P00519 601 KWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSIS 5wnm A 2.6 BS01 VX6 A 1 V28 A49 M96 E97 Y98 M99 E100 T101 G102 A147 L150 D161 V19 A38 M85 E86 Y87 M88 E89 T90 G91 A136 L139 D150 N143 A147 N148 D161 N132 A136 N137 D150 2.7.11.1 0004672,0005524,0006468 Q9ERK0 29706531 402 ALGLLRTFDAGEFAGWEKVGSFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERMELLEEAKKMEMAKFRYILPVYGICQEPVGLVMEYMETGSLEKLLASEPLPWDLRFRIVHETAVGMNFLHCMSPPLLHLNLKPANILLDAHYHVKISDFGLAKFGTIAYLPPERIREKSRLFDTKHDVYSFAIVIWGVLTQKKPFADEKNILHIMMKVVKGHRPELPPICRPRPRACASLIGLMQRCWHADPQVRPTFQEITSETEDLCEK 6brj A 2.231 BS01 VX6 A 1 L579 A616 Y666 M667 E668 G670 L736 F748 M750 R752 L12 A29 Y79 M80 E81 G83 L134 F146 M148 R150 D729 R733 N734 D747 D127 R131 N132 D145 2.7.10.1 0004672,0004713,0004714,0005524,0006468,0007169,0016020 Kd=28nM Q08345 30612951 901 FPRSRLRFKEKLGEGQFGEVHLCEVLLVAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLHRFLAEDALNTV 6gr9 A 2.25 BS01 VX6 A 1 G50 F54 A70 E121 Y122 A123 P124 G126 L173 A183 G14 F18 A34 E85 Y86 A87 P88 G90 L137 A147 D166 K168 E170 N171 D184 T202 D130 K132 E134 N135 D148 T166 2.7.11.1 0004672,0005524,0006468 Ki=4.6nM, Kd=6.3nM, IC50=25nM Q9UQB9 401 RLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSDKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRRVLPPCA