1nu3 A 1.75 BS01 VPR A 1 I80 D101 L103 F134 F139 I76 D97 L99 F130 F135 Y53 N55 R99 D101 D132 Y49 N51 R95 D97 D128 3.3.2.8 0016787,0018744 -logKd/Ki=4.00, Ki=100uM Q9ZAG3 12773375 4001 IEQPRWASKDSAAGAASTPDEKIVLEFMDALTSNDAAKLIEYFAEDTMYQNMPLPPAYGRDAVEQTLAGLFTVMSIDAVETFHIGSSNGLVYTERVDVLRALPTGKSYNLSILGVFQLTEGKITGWRDYFDLREFEEAVDLPLRG 1nu3 B 1.75 BS01 VPR B 1 L74 I80 D101 L103 F134 L72 I78 D99 L101 F132 Y53 N55 R99 D101 D132 Y51 N53 R97 D99 D130 3.3.2.8 0016787,0018744 Q9ZAG3 12773375 5001 SKIEQPRWASKDSAAGAASTPDEKIVLEFMDALTSNDAAKLIEYFAEDTMYQNMPLPPAYGRDAVEQTLAGLFTVMSIDAVETFHIGSSNGLVYTERVDVLRALPTGKSYNLSILGVFQLTEGKITGWRDYFDLREFEEAVDLPLRG 2cjp B 1.95 BS01 VPR B 1 F33 D105 Y154 I180 F189 L266 H300 F301 F31 D103 Y152 I178 F187 L264 H298 F299 F33 D105 W106 S129 Y154 Y235 D265 H300 F31 D103 W104 S127 Y152 Y233 D263 H298 3.3.2.3 0003824,0004301,0016787 Ki=0.8mM Q41415 16751602 1322 KIEHKMVAVNGLNMHLAELGEGPTILFIHGFPELWYSWRHQMVYLAERGYRAVAPDLRGYGDTTGAPLNDPSKFSILHLVGDVVALLEAIAPNEEKVFVVAHDWGALIAWHLCLFRPDKVKALVNLSVHFSKRNPKMNVVEGLKAIYGEDHYISRFQVPGEIEAEFAPIGAKSVLKKILTYRDPAPFYFPKGKGLEAIPDAPVALSSWLSEEELDYYANKFEQTGFTGAVNYYRALPINWELTAPWTGAQVKVPTKFIVGEFDLVYHIPGAKEYIHNGGFKKDVPLLEEVVVLEGAAHFVSQERPHEISKHIYDFIQKF 3g0i A 2.1 BS01 VPR A 1 D192 L215 F244 Y251 Y314 T317 D190 L213 F242 Y249 Y312 T315 3.3.2.3 0003824,0004301,0016787,0016803,0097176 -logKd/Ki=3.60, Ki=250uM Q9UR30 19469578 1 KAFAKFPSSASISPNPFTVSIPDEQLDDLKTLVRLSKIAPPTYESLQADGRFGITSEWLTTMREKWLSEFDWRPFEARLNSFPQFTTEIEGLTIHFAALFSEREDAVPIALLHGWPGSFVEFYPILQLFREEYTPETLPFHLVVPSLPGYTFSSGPPLDKDFGLMDNARVVDQLMKDLGFGSGYIIQGGDIGSFVGRLLGVGFDACKAVHLNLCAMRAPPEGPSIESLSAAEKEGIARMEKFMTDGLAYAMEHSTRPSTIGHVLSSSPIALLAWIGEKYLQWVDKPLPSETILEMVSLYWLTESFPRAIHTYRETTPMLQKELYIHKPFGFSFFPKDLCPVPRSWIATTGNLVFFRDHAEGGHFAALERPRELKTDLTAFVEQVW 3g0i B 2.1 BS01 VPR B 1 D192 L215 F244 Y251 W284 Y314 T317 L349 D190 L213 F242 Y249 W282 Y312 T315 L338 3.3.2.3 0003824,0004301,0016787,0016803,0097176 Q9UR30 19469578 1 KAFAKFPSSASISPNPFTVSIPDEQLDDLKTLVRLSKIAPPTYESLQADGRFGITSEWLTTMREKWLSEFDWRPFEARLNSFPQFTTEIEGLTIHFAALFSEREDAVPIALLHGWPGSFVEFYPILQLFREEYTPETLPFHLVVPSLPGYTFSSGPPLDKDFGLMDNARVVDQLMKDLGFGSGYIIQGGDIGSFVGRLLGVGFDACKAVHLNLCAMRAPPEGPSIESLSAAEKEGIARMEKFMTDGLAYAMEHSTRPSTIGHVLSSSPIALLAWIGEKYLQWVDKPLPSETILEMVSLYWLTESFPRAIHTYRETTPMLQKELYIHKPFGFSFFPKDLCPVPRSWIATTGNLVFFRDHAEGGHFAALERPRELKTDLTAFVEQVW 5aig A 1.16 BS01 VPR A 1 W62 D80 F82 F113 F118 W62 D80 F82 F113 F118 26032250 200 MTPIETVTAFIAHWNSGDMEAMYDLCAEDVVWHNIPMEPIAGKPAMRAAVEGFMANVSQCDWQVHAIAANGATVLTERTDGFTFTNGRRATIRVMGTFECDAERRIIAWRDYFDMLEFQREFAG 5aig B 1.16 BS01 VPR B 1 F53 W62 D80 F82 F118 F122 F53 W62 D80 F82 F118 F122 26032250 200 MTPIETVTAFIAHWNSGDMEAMYDLCAEDVVWHNIPMEPIAGKPAMRAAVEGFMANVSQCDWQVHAIAANGATVLTERTDGFTFTNGRRATIRVMGTFECDAERRIIAWRDYFDMLEFQREFAG