3wq5 A 1.8 BS01 VPA A 1 Q53 H157 N202 E203 S206 Y345 F389 E416 W463 E470 W471 S473 Q477 F479 Q21 H125 N170 E171 S174 Y313 F357 E384 W431 E438 W439 S441 Q445 F447 R111 H157 E203 S206 N343 Y345 E416 R79 H125 E171 S174 N311 Y313 E384 3.2.1.149 0004553,0005975,0008422,0016798,0050535 -logKd/Ki=3.85, Ki=140uM Q7X9A9 24753293 601 SFNRTSFPDGFVFGAASSAYQFEGAAKEGGKGPNIWDTFTHEFPGKISNGSTGDVADDFYHRYKEDVKVLKFIGLDGFRMSISWARVLPRGKLSGGVNKEGIAFYNNVINDLLSKGIQPFITIFHWDLPQALEDEYGGFLSPHIVNDFRDFAELCFKEFGDRVKHWITMNEPWSYSYGGYDAGLLAPGRCSAFMAFCPKGNSGTEPYIVTHNLLLSHAAAVKLYKEKYQAYQKGQIGITLVTYWMIPYSNSKADKDAAQRALDFMYGWFIEPLSFGEYPKSMRRLVGKRLPRFTKEQAMLVKGSFDFLGLNYYIANYVLNVPTSNSVNLSYTTDSLSNQTAFRNGVAIGRPTGVPAFFMYPKGLKDLLVYTKEKYNDPVIYITENGMGDNNNVTTEEGIKDPQRVYFYNQHLLSLKNAIAAGVKVKGYFTWAFLDNFEWLSGYTQRFGIVYVDFKDGLKRYPKHSALWFKKFLLK 3wq5 A 1.8 BS02 VPA A 2 A58 K59 K63 G64 P65 P121 R122 A163 A26 K27 K31 G32 P33 P89 R90 A131 R111 H157 E203 S206 N343 Y345 E416 R79 H125 E171 S174 N311 Y313 E384 3.2.1.149 0004553,0005975,0008422,0016798,0050535 -logKd/Ki=3.85, Ki=140uM Q7X9A9 24753293 606 SFNRTSFPDGFVFGAASSAYQFEGAAKEGGKGPNIWDTFTHEFPGKISNGSTGDVADDFYHRYKEDVKVLKFIGLDGFRMSISWARVLPRGKLSGGVNKEGIAFYNNVINDLLSKGIQPFITIFHWDLPQALEDEYGGFLSPHIVNDFRDFAELCFKEFGDRVKHWITMNEPWSYSYGGYDAGLLAPGRCSAFMAFCPKGNSGTEPYIVTHNLLLSHAAAVKLYKEKYQAYQKGQIGITLVTYWMIPYSNSKADKDAAQRALDFMYGWFIEPLSFGEYPKSMRRLVGKRLPRFTKEQAMLVKGSFDFLGLNYYIANYVLNVPTSNSVNLSYTTDSLSNQTAFRNGVAIGRPTGVPAFFMYPKGLKDLLVYTKEKYNDPVIYITENGMGDNNNVTTEEGIKDPQRVYFYNQHLLSLKNAIAAGVKVKGYFTWAFLDNFEWLSGYTQRFGIVYVDFKDGLKRYPKHSALWFKKFLLK 3wq5 B 1.8 BS01 VPA B 1 Q53 H157 N202 E203 S206 Y345 F389 E416 W463 E470 W471 S473 Q477 F479 Q20 H124 N169 E170 S173 Y312 F356 E383 W430 E437 W438 S440 Q444 F446 R111 H157 E203 S206 N343 Y345 E416 R78 H124 E170 S173 N310 Y312 E383 3.2.1.149 0004553,0005975,0008422,0016798,0050535 Q7X9A9 24753293 601 FNRTSFPDGFVFGAASSAYQFEGAAKEGGKGPNIWDTFTHEFPGKISNGSTGDVADDFYHRYKEDVKVLKFIGLDGFRMSISWARVLPRGKLSGGVNKEGIAFYNNVINDLLSKGIQPFITIFHWDLPQALEDEYGGFLSPHIVNDFRDFAELCFKEFGDRVKHWITMNEPWSYSYGGYDAGLLAPGRCSAFMAFCPKGNSGTEPYIVTHNLLLSHAAAVKLYKEKYQAYQKGQIGITLVTYWMIPYSNSKADKDAAQRALDFMYGWFIEPLSFGEYPKSMRRLVGKRLPRFTKEQAMLVKGSFDFLGLNYYIANYVLNVPTSNSVNLSYTTDSLSNQTAFRNGVAIGRPTGVPAFFMYPKGLKDLLVYTKEKYNDPVIYITENGMGDNNNVTTEEGIKDPQRVYFYNQHLLSLKNAIAAGVKVKGYFTWAFLDNFEWLSGYTQRFGIVYVDFKDGLKRYPKHSALWFKKFLLK