1bo6 A 2.1 BS01 VO4 A 1 P47 K48 T51 K106 H108 F255 P42 K43 T46 K94 H96 F243 K48 H108 S138 K43 H96 S126 2.8.2.4 0004304,0005496,0005737,0005829,0006629,0007565,0008146,0008210,0016740,0050294,0051923 P49891 9765259 302 PEYYEVFGEFRGVLMDKRFTKYWEDVEMFLARPDDLVIATYPKSGTTWISEVVYMIYKEGDAIFNRIPYLECRNEDLINGIKQLKEKESPRIVKTHLPPKLLPASFWEKNCKMIYLCRNAKDVAVSYYYFLLMITSYPNPKSFSEFVEKFMQGQVPYGSWYDHVKAWWEKSKNSRVLFMFYEDMKEDIRREVVKLIEFLERKPSAELVDRIIQHTSFQEMKNNPSTNYTMMPEEMMNQKVSPFMRKGIIGDWKNHFPEALRERFDEHYKQQMKDCTVKFRME 1bo6 B 2.1 BS01 VO4 B 1 P47 K48 T51 K106 H108 F255 P41 K42 T45 K94 H96 F243 K48 H108 S138 K42 H96 S126 2.8.2.4 0004304,0005496,0005737,0005829,0006629,0007565,0008146,0008210,0016740,0050294,0051923 P49891 9765259 304 EYYEVFGEFRGVLMDKRFTKYWEDVEMFLARPDDLVIATYPKSGTTWISEVVYMIYKEKEDAIFNRIPYLECRNEDLINGIKQLKEKESPRIVKTHLPPKLLPASFWEKNCKMIYLCRNAKDVAVSYYYFLLMITSYPNPKSFSEFVEKFMQGQVPYGSWYDHVKAWWEKSKNSRVLFMFYEDMKEDIRREVVKLIEFLERKPSAELVDRIIQHTSFQEMKNNPSTNYTMMPEEMMNQKVSPFMRKGIIGDWKNHFPEALRERFDEHYKQQMKDCTVKFRME 1j9l A 1.9 BS03 VO4 A 1 D8 S39 N95 N99 S107 G108 T109 D8 S39 N95 N99 S107 G108 T109 3.1.3.5 0000166,0004309,0005737,0008252,0008253,0008254,0016787,0046872,0106411 P96112 11524683 401 MRILVTNDDGIQSKGIIVLAELLSEEHEVFVVAPDKERSATGHSITIHVPLWMKKVFISERVVAYSTTGTPADCVKLAYNVVMDKRVDLIVSGVNRGPNMGMDILHSGTVSGAMEGAMMNIPSIAISSANYESPDFEGAARFLIDFLKEFDFSLLDPFTMLNINVPAGEIKGWRFTRQSRRRWNDYFEERVSPFGEKYYWMMGEVIEDDDRDDVDYKAVREGYVSITPIHPFLTNEQCLKKLREVYD 1j9l B 1.9 BS02 VO4 B 1 D8 S39 N95 N99 S107 G108 T109 D8 S39 N95 N99 S107 G108 T109 3.1.3.5 0000166,0004309,0005737,0008252,0008253,0008254,0016787,0046872,0106411 P96112 11524683 1401 MRILVTNDDGIQSKGIIVLAELLSEEHEVFVVAPDKERSATGHSITIHVPLWMKKVFISERVVAYSTTGTPADCVKLAYNVVMDKRVDLIVSGVNRGPNMGMDILHSGTVSGAMEGAMMNIPSIAISSANYESPDFEGAARFLIDFLKEFDFSLLDPFTMLNINVPAGEIKGWRFTRQSRRRWNDYFEERVSPFGEKYYWMMGEVIEDDDRDDVDYKAVREGYVSITPIHPFLTNEQCLKKLREVYD 1mu9 A 2.05 BS01 VO4 A 1 H263 K265 N283 H493 K495 H102 K104 N122 H318 K320 3.1.4.- 0005634,0006281,0008081 IC50=4000nM Q9NUW8 12470949 609 NPFQFYLTRVSGVKPKYNSGALHIKDILSPLFGTLVSSAQFNYCFDVDWLVKQYPPEFRKKPILLVHGDKREAKAHLHAQAKPYENISLCQAKLDIAFGTHHTKMMLLLYEEGLRVVIHTSNLIHADWHQKTQGIWLSPLYPRIADGTHKSGESPTHFKANLISYLTAYNAPSLKEWIDVIHKHDLSETNVYLIGSTPGRFQGSQKDNWGHFRLKKLLKDHASSMSWPVVGQFSSVGSLGADESKWLCSEFKESMLTLGVPLYLIYPSVENVRTSLEGYPAGGSLPYSIQTAEKQNWLHSYFHKWSAETSGRSNAMPHIKTYMRPSPDFSKIAWFLVTSANLSKAAWGALEKNGTQLMIRSYELGVLFLPSALGLDSFKVKQKFATFPVPYDLPPELYGSKDRPWIWNIPYVKAPDTHGNMWVPS 1mu9 B 2.05 BS01 VO4 B 1 H263 K265 N283 H493 K495 H105 K107 N125 H326 K328 3.1.4.- 0005634,0006281,0008081 IC50=4000nM Q9NUW8 12470949 609 DKGNPFQFYLTRVSGVKPKYNSGALHIKDILSPLFGTLVSSAQFNYCFDVDWLVKQYPPEFRKKPILLVHGDKREAKAHLHAQAKPYENISLCQAKLDIAFGTHHTKMMLLLYEEGLRVVIHTSNLIHADWHQKTQGIWLSPLYPRIADGTHKSGESPTHFKANLISYLTAYNAPSLKEWIDVIHKHDLSETNVYLIGSTPGRFQGSQKDNWGHFRLKKLLKDHASSMPNAESWPVVGQFSSVGSLGADESKWLCSEFKESMLTLGSVPLYLIYPSVENVRTSLEGYPAGGSLPYSIQTAEKQNWLHSYFHKWSAETSGRSNAMPHIKTYMRPSPDFSKIAWFLVTSANLSKAAWGALEKNGTQLMIRSYELGVLFLPSALGLDSFKVKQKFMATFPVPYDLPPELYGSKDRPWIWNIPYVKAPDTHGNMWVPS 1nop A 2.3 BS03 VO4 A 1 H263 K265 N283 H493 K495 N516 H102 K104 N122 H318 K320 N341 3.1.4.- 0005634,0006281,0008081 IC50=4000nM Q9NUW8 12618186 699 NPFQFYLTRVSGVKPKYNSGALHIKDILSPLFGTLVSSAQFNYCFDVDWLVKQYPPEFRKKPILLVHGDKREAKAHLHAQAKPYENISLCQAKLDIAFGTHHTKMMLLLYEEGLRVVIHTSNLIHADWHQKTQGIWLSPLYPRIADGTHKSGESPTHFKANLISYLTAYNAPSLKEWIDVIHKHDLSETNVYLIGSTPGRFQGSQKDNWGHFRLKKLLKDHASSMSWPVVGQFSSVGSLGADESKWLCSEFKESMLTLGVPLYLIYPSVENVRTSLEGYPAGGSLPYSIQTAEKQNWLHSYFHKWSAETSGRSNAMPHIKTYMRPSPDFSKIAWFLVTSANLSKAAWGALEKNGTQLMIRSYELGVLFLPSALGLDSFKVKQKFATFPVPYDLPPELYGSKDRPWIWNIPYVKAPDTHGNMWVPS 1nop B 2.3 BS02 VO4 B 1 H263 K265 H493 K495 H105 K107 H326 K328 3.1.4.- 0005634,0006281,0008081 IC50=4000nM Q9NUW8 12618186 699 DKGNPFQFYLTRVSGVKPKYNSGALHIKDILSPLFGTLVSSAQFNYCFDVDWLVKQYPPEFRKKPILLVHGDKREAKAHLHAQAKPYENISLCQAKLDIAFGTHHTKMMLLLYEEGLRVVIHTSNLIHADWHQKTQGIWLSPLYPRIADGTHKSGESPTHFKANLISYLTAYNAPSLKEWIDVIHKHDLSETNVYLIGSTPGRFQGSQKDNWGHFRLKKLLKDHASSMPNAESWPVVGQFSSVGSLGADESKWLCSEFKESMLTLGSVPLYLIYPSVENVRTSLEGYPAGGSLPYSIQTAEKQNWLHSYFHKWSAETSGRSNAMPHIKTYMRPSPDFSKIAWFLVTSANLSKAAWGALEKNGTQLMIRSYELGVLFLPSALGLDSFKVKQKFMATFPVPYDLPPELYGSKDRPWIWNIPYVKAPDTHGNMWVP 1rff A 1.7 BS03 VO4 A 1 H263 K265 H493 K495 H102 K104 H318 K320 3.1.4.- 0005634,0006281,0008081 IC50=4000nM Q9NUW8 14761185 699 NPFQFYLTRVSGVKPKYNSGALHIKDILSPLFGTLVSSAQFNYCFDVDWLVKQYPPEFRKKPILLVHGDKREAKAHLHAQAKPYENISLCQAKLDIAFGTHHTKMMLLLYEEGLRVVIHTSNLIHADWHQKTQGIWLSPLYPRIADGTHKSGESPTHFKANLISYLTAYNAPSLKEWIDVIHKHDLSETNVYLIGSTPGRFQGSQKDNWGHFRLKKLLKDHASSMSWPVVGQFSSVGSLGADESKWLCSEFKESMLTLGVPLYLIYPSVENVRTSLEGYPAGGSLPYSIQTAEKQNWLHSYFHKWSAETSGRSNAMPHIKTYMRPSPDFSKIAWFLVTSANLSKAAWGALEKNGTQLMIRSYELGVLFLPSALGLDSFKVKQKFATFPVPYDLPPELYGSKDRPWIWNIPYVKAPDTHGNMWVPS 1rff B 1.7 BS03 VO4 B 1 H263 K265 N283 H493 K495 H102 K104 N122 H323 K325 3.1.4.- 0005634,0006281,0008081 IC50=4000nM Q9NUW8 14761185 699 NPFQFYLTRVSGVKPKYNSGALHIKDILSPLFGTLVSSAQFNYCFDVDWLVKQYPPEFRKKPILLVHGDKREAKAHLHAQAKPYENISLCQAKLDIAFGTHHTKMMLLLYEEGLRVVIHTSNLIHADWHQKTQGIWLSPLYPRIADGTHKSGESPTHFKANLISYLTAYNAPSLKEWIDVIHKHDLSETNVYLIGSTPGRFQGSQKDNWGHFRLKKLLKDHASSMPNAESWPVVGQFSSVGSLGADESKWLCSEFKESMLTLGSVPLYLIYPSVENVRTSLEGYPAGGSLPYSIQTAEKQNWLHSYFHKWSAETSGRSNAMPHIKTYMRPSPDFSKIAWFLVTSANLSKAAWGALEKNGTQLMIRSYELGVLFLPSALGLDSFKVKQKFFTFPVPYDLPPELYGSKDRPWIWNIPYVKAPDTHGNMWVP 1rfi A 2.2 BS03 VO4 A 1 H263 K265 H493 K495 H102 K104 H318 K320 3.1.4.- 0005634,0006281,0008081 IC50=4000nM Q9NUW8 14761185 699 NPFQFYLTRVSGVKPKYNSGALHIKDILSPLFGTLVSSAQFNYCFDVDWLVKQYPPEFRKKPILLVHGDKREAKAHLHAQAKPYENISLCQAKLDIAFGTHHTKMMLLLYEEGLRVVIHTSNLIHADWHQKTQGIWLSPLYPRIADGTHKSGESPTHFKANLISYLTAYNAPSLKEWIDVIHKHDLSETNVYLIGSTPGRFQGSQKDNWGHFRLKKLLKDHASSMSWPVVGQFSSVGSLGADESKWLCSEFKESMLTLGVPLYLIYPSVENVRTSLEGYPAGGSLPYSIQTAEKQNWLHSYFHKWSAETSGRSNAMPHIKTYMRPSPDFSKIAWFLVTSANLSKAAWGALEKNGTQLMIRSYELGVLFLPSALGLDSFKVKQKFATFPVPYDLPPELYGSKDRPWIWNIPYVKAPDTHGNMWVPS 1rfi B 2.2 BS03 VO4 B 1 H263 K265 H493 K495 H102 K104 H323 K325 3.1.4.- 0005634,0006281,0008081 IC50=4000nM Q9NUW8 14761185 699 NPFQFYLTRVSGVKPKYNSGALHIKDILSPLFGTLVSSAQFNYCFDVDWLVKQYPPEFRKKPILLVHGDKREAKAHLHAQAKPYENISLCQAKLDIAFGTHHTKMMLLLYEEGLRVVIHTSNLIHADWHQKTQGIWLSPLYPRIADGTHKSGESPTHFKANLISYLTAYNAPSLKEWIDVIHKHDLSETNVYLIGSTPGRFQGSQKDNWGHFRLKKLLKDHASSMPNAESWPVVGQFSSVGSLGADESKWLCSEFKESMLTLGSVPLYLIYPSVENVRTSLEGYPAGGSLPYSIQTAEKQNWLHSYFHKWSAETSGRSNAMPHIKTYMRPSPDFSKIAWFLVTSANLSKAAWGALEKNGTQLMIRSYELGVLFLPSALGLDSFKVKQKFFTFPVPYDLPPELYGSKDRPWIWNIPYVKAPDTHGNMWVP 1rg1 A 2.1 BS02 VO4 A 1 H263 K265 H493 K495 H102 K104 H318 K320 3.1.4.- 0005634,0006281,0008081 IC50=4000nM Q9NUW8 14761185 699 NPFQFYLTRVSGVKPKYNSGALHIKDILSPLFGTLVSSAQFNYCFDVDWLVKQYPPEFRKKPILLVHGDKREAKAHLHAQAKPYENISLCQAKLDIAFGTHHTKMMLLLYEEGLRVVIHTSNLIHADWHQKTQGIWLSPLYPRIADGTHKSGESPTHFKANLISYLTAYNAPSLKEWIDVIHKHDLSETNVYLIGSTPGRFQGSQKDNWGHFRLKKLLKDHASSMSWPVVGQFSSVGSLGADESKWLCSEFKESMLTLGVPLYLIYPSVENVRTSLEGYPAGGSLPYSIQTAEKQNWLHSYFHKWSAETSGRSNAMPHIKTYMRPSPDFSKIAWFLVTSANLSKAAWGALEKNGTQLMIRSYELGVLFLPSALGLDSFKVKQKFTFPVPYDLPPELYGSKDRPWIWNIPYVKAPDTHGNMWVPS 1rg1 B 2.1 BS02 VO4 B 1 H263 K265 N283 H493 K495 H102 K104 N122 H322 K324 3.1.4.- 0005634,0006281,0008081 IC50=4000nM Q9NUW8 14761185 699 NPFQFYLTRVSGVKPKYNSGALHIKDILSPLFGTLVSSAQFNYCFDVDWLVKQYPPEFRKKPILLVHGDKREAKAHLHAQAKPYENISLCQAKLDIAFGTHHTKMMLLLYEEGLRVVIHTSNLIHADWHQKTQGIWLSPLYPRIADGTHKSGESPTHFKANLISYLTAYNAPSLKEWIDVIHKHDLSETNVYLIGSTPGRFQGSQKDNWGHFRLKKLLKDHASSMPNAESWPVVGQFSSVGSLGADESKWLCSEFKESMLTLGVPLYLIYPSVENVRTSLEGYPAGGSLPYSIQTAEKQNWLHSYFHKWSAETSGRSNAMPHIKTYMRPSPDFSKIAWFLVTSANLSKAAWGALEKNGTQLMIRSYELGVLFLPSALGLDSFKVKQKFFATFPVPYDLPPELYGSKDRPWIWNIPYVKAPDTHGNMWVP 1rg2 A 2.1 BS02 VO4 A 1 H263 K265 H493 K495 H102 K104 H318 K320 3.1.4.- 0005634,0006281,0008081 IC50=4000nM Q9NUW8 14761185 699 NPFQFYLTRVSGVKPKYNSGALHIKDILSPLFGTLVSSAQFNYCFDVDWLVKQYPPEFRKKPILLVHGDKREAKAHLHAQAKPYENISLCQAKLDIAFGTHHTKMMLLLYEEGLRVVIHTSNLIHADWHQKTQGIWLSPLYPRIADGTHKSGESPTHFKANLISYLTAYNAPSLKEWIDVIHKHDLSETNVYLIGSTPGRFQGSQKDNWGHFRLKKLLKDHASSMSWPVVGQFSSVGSLGADESKWLCSEFKESMLTLGVPLYLIYPSVENVRTSLEGYPAGGSLPYSIQTAEKQNWLHSYFHKWSAETSGRSNAMPHIKTYMRPSPDFSKIAWFLVTSANLSKAAWGALEKNGTQLMIRSYELGVLFLPSALGLDSFKVKQKFATFPVPYDLPPELYGSKDRPWIWNIPYVKAPDTHGNMWVPS 1rg2 B 2.1 BS02 VO4 B 1 H263 K265 H493 K495 H105 K107 H326 K328 3.1.4.- 0005634,0006281,0008081 IC50=4000nM Q9NUW8 14761185 699 DKGNPFQFYLTRVSGVKPKYNSGALHIKDILSPLFGTLVSSAQFNYCFDVDWLVKQYPPEFRKKPILLVHGDKREAKAHLHAQAKPYENISLCQAKLDIAFGTHHTKMMLLLYEEGLRVVIHTSNLIHADWHQKTQGIWLSPLYPRIADGTHKSGESPTHFKANLISYLTAYNAPSLKEWIDVIHKHDLSETNVYLIGSTPGRFQGSQKDNWGHFRLKKLLKDHASSMPNAESWPVVGQFSSVGSLGADESKWLCSEFKESMLTLGSVPLYLIYPSVENVRTSLEGYPAGGSLPYSIQTAEKQNWLHSYFHKWSAETSGRSNAMPHIKTYMRPSPDFSKIAWFLVTSANLSKAAWGALEKNGTQLMIRSYELGVLFLPSALGLDSFKVKQKFMATFPVPYDLPPELYGSKDRPWIWNIPYVKAPDTHGNMWVPS 1rgt A 2.0 BS02 VO4 A 1 H263 K265 H493 K495 H102 K104 H318 K320 3.1.4.- 0005634,0006281,0008081 IC50=4000nM Q9NUW8 14761185 699 NPFQFYLTRVSGVKPKYNSGALHIKDILSPLFGTLVSSAQFNYCFDVDWLVKQYPPEFRKKPILLVHGDKREAKAHLHAQAKPYENISLCQAKLDIAFGTHHTKMMLLLYEEGLRVVIHTSNLIHADWHQKTQGIWLSPLYPRIADGTHKSGESPTHFKANLISYLTAYNAPSLKEWIDVIHKHDLSETNVYLIGSTPGRFQGSQKDNWGHFRLKKLLKDHASSMSWPVVGQFSSVGSLGADESKWLCSEFKESMLTLGVPLYLIYPSVENVRTSLEGYPAGGSLPYSIQTAEKQNWLHSYFHKWSAETSGRSNAMPHIKTYMRPSPDFSKIAWFLVTSANLSKAAWGALEKNGTQLMIRSYELGVLFLPSALGLDSFKVKQKFTFPVPYDLPPELYGSKDRPWIWNIPYVKAPDTHGNMWVPS 1rgt B 2.0 BS02 VO4 B 1 H263 K265 N283 H493 K495 H102 K104 N122 H323 K325 3.1.4.- 0005634,0006281,0008081 IC50=4000nM Q9NUW8 14761185 699 NPFQFYLTRVSGVKPKYNSGALHIKDILSPLFGTLVSSAQFNYCFDVDWLVKQYPPEFRKKPILLVHGDKREAKAHLHAQAKPYENISLCQAKLDIAFGTHHTKMMLLLYEEGLRVVIHTSNLIHADWHQKTQGIWLSPLYPRIADGTHKSGESPTHFKANLISYLTAYNAPSLKEWIDVIHKHDLSETNVYLIGSTPGRFQGSQKDNWGHFRLKKLLKDHASSMPNAESWPVVGQFSSVGSLGADESKWLCSEFKESMLTLGSVPLYLIYPSVENVRTSLEGYPAGGSLPYSIQTAEKQNWLHSYFHKWSAETSGRSNAMPHIKTYMRPSPDFSKIAWFLVTSANLSKAAWGALEKNGTQLMIRSYELGVLFLPSALGLDSFKVKQKFFTFPVPYDLPPELYGSKDRPWIWNIPYVKAPDTHGNMWVP 1rgu A 2.22 BS02 VO4 A 1 H263 K265 H493 K495 H102 K104 H318 K320 3.1.4.- 0005634,0006281,0008081 IC50=4000nM Q9NUW8 14761185 699 NPFQFYLTRVSGVKPKYNSGALHIKDILSPLFGTLVSSAQFNYCFDVDWLVKQYPPEFRKKPILLVHGDKREAKAHLHAQAKPYENISLCQAKLDIAFGTHHTKMMLLLYEEGLRVVIHTSNLIHADWHQKTQGIWLSPLYPRIADGTHKSGESPTHFKANLISYLTAYNAPSLKEWIDVIHKHDLSETNVYLIGSTPGRFQGSQKDNWGHFRLKKLLKDHASSMSWPVVGQFSSVGSLGADESKWLCSEFKESMLTLGVPLYLIYPSVENVRTSLEGYPAGGSLPYSIQTAEKQNWLHSYFHKWSAETSGRSNAMPHIKTYMRPSPDFSKIAWFLVTSANLSKAAWGALEKNGTQLMIRSYELGVLFLPSALGLDSFKVKQKFATFPVPYDLPPELYGSKDRPWIWNIPYVKAPDTHGNMWVPS 1rgu B 2.22 BS02 VO4 B 1 H263 K265 H493 K495 N516 H102 K104 H323 K325 N346 3.1.4.- 0005634,0006281,0008081 IC50=4000nM Q9NUW8 14761185 699 NPFQFYLTRVSGVKPKYNSGALHIKDILSPLFGTLVSSAQFNYCFDVDWLVKQYPPEFRKKPILLVHGDKREAKAHLHAQAKPYENISLCQAKLDIAFGTHHTKMMLLLYEEGLRVVIHTSNLIHADWHQKTQGIWLSPLYPRIADGTHKSGESPTHFKANLISYLTAYNAPSLKEWIDVIHKHDLSETNVYLIGSTPGRFQGSQKDNWGHFRLKKLLKDHASSMPNAESWPVVGQFSSVGSLGADESKWLCSEFKESMLTLGSVPLYLIYPSVENVRTSLEGYPAGGSLPYSIQTAEKQNWLHSYFHKWSAETSGRSNAMPHIKTYMRPSPDFSKIAWFLVTSANLSKAAWGALEKNGTQLMIRSYELGVLFLPSALGLDSFKVKQKFFTFPVPYDLPPELYGSKDRPWIWNIPYVKAPDTHGNMWVP 1rh0 A 2.3 BS02 VO4 A 1 H263 K265 H493 K495 H102 K104 H318 K320 3.1.4.- 0005634,0006281,0008081 IC50=4000nM Q9NUW8 14761185 699 NPFQFYLTRVSGVKPKYNSGALHIKDILSPLFGTLVSSAQFNYCFDVDWLVKQYPPEFRKKPILLVHGDKREAKAHLHAQAKPYENISLCQAKLDIAFGTHHTKMMLLLYEEGLRVVIHTSNLIHADWHQKTQGIWLSPLYPRIADGTHKSGESPTHFKANLISYLTAYNAPSLKEWIDVIHKHDLSETNVYLIGSTPGRFQGSQKDNWGHFRLKKLLKDHASSMSWPVVGQFSSVGSLGADESKWLCSEFKESMLTLGVPLYLIYPSVENVRTSLEGYPAGGSLPYSIQTAEKQNWLHSYFHKWSAETSGRSNAMPHIKTYMRPSPDFSKIAWFLVTSANLSKAAWGALEKNGTQLMIRSYELGVLFLPSALGLDSFKVKQKFATFPVPYDLPPELYGSKDRPWIWNIPYVKAPDTHGNMWVPS 1rh0 B 2.3 BS02 VO4 B 1 H263 K265 H493 K495 H102 K104 H323 K325 3.1.4.- 0005634,0006281,0008081 IC50=4000nM Q9NUW8 14761185 699 NPFQFYLTRVSGVKPKYNSGALHIKDILSPLFGTLVSSAQFNYCFDVDWLVKQYPPEFRKKPILLVHGDKREAKAHLHAQAKPYENISLCQAKLDIAFGTHHTKMMLLLYEEGLRVVIHTSNLIHADWHQKTQGIWLSPLYPRIADGTHKSGESPTHFKANLISYLTAYNAPSLKEWIDVIHKHDLSETNVYLIGSTPGRFQGSQKDNWGHFRLKKLLKDHASSMPNAESWPVVGQFSSVGSLGADESKWLCSEFKESMLTLGSVPLYLIYPSVENVRTSLEGYPAGGSLPYSIQTAEKQNWLHSYFHKWSAETSGRSNAMPHIKTYMRPSPDFSKIAWFLVTSANLSKAAWGALEKNGTQLMIRSYELGVLFLPSALGLDSFKVKQKFFTFPVPYDLPPELYGSKDRPWIWNIPYVKAPDTHGNMWVP 1rpt A 3.0 BS01 VO4 A 1 R11 H12 R15 R79 H257 D258 R11 H12 R15 R79 H257 D258 R11 H12 R15 R79 H257 D258 R11 H12 R15 R79 H257 D258 3.1.3.2,3.1.3.48,3.1.3.5 0003993,0004725,0005576,0005615,0005764,0005765,0005771,0005886,0006144,0006629,0006772,0007040,0008253,0009117,0012506,0016020,0016311,0016787,0016791,0030141,0030175,0031985,0033265,0042131,0042802,0042803,0045177,0046085,0051930,0052642,0060090,0060168,0106411 P20646 8168503 343 KELKFVTLVFRHGDRGPIETFPNDPIKESSWPQGFGQLTKWGMGQHYELGSYIRRRYGRFLNNSYKHDQVYIRSTDVDRTLMSAMTNLAALFPPEGNSIWNPRLLWQPIPVHTVSLSEDRLLYLPFRDCPRFQELKSETLKSEEFLKRLQPYKSFIDTLPSLSGFEDQDLFEIWSRLYDPLYCESVHNFTLPTWATEDAMTKLKELSELSLLSLYGIHKQKEKSRLQGGVLVNEILKNMKLATQPQKARKLIMYSAHDTTVSGLQMALDVYNGLLPPYASCHIMELYQDNGGHFVEMYYRNETQNEPYPLTLPGCTHSCPLEKFAELLDPVIPQDWATECMG 1vnc A 2.1 BS01 VO4 A 1 K353 R360 S402 G403 H404 R490 H496 K351 R358 S400 G401 H402 R488 H494 K353 R360 S402 G403 H404 R490 H496 K351 R358 S400 G401 H402 R488 H494 1.11.1.10 0004601,0005576,0016691,0046872,0098869 P49053 8552646 610 SVTPIPLPKIDEPEEYNTNYILFWNHVGLELNRVTHTVGGPLTGPPLSARALGMLHLAIHDAYFSICPPTDFTTFLSPDTENAAYRLPSPNGANDARQAVAGAALKMLSSLYMKPVEQPNPNPGANISDNAYAQLGLVLDRSVLEAPGGVDRESASFMFGEDVADVFFALLNDPRGASQEGYHPTPGRYKFDDEPTHPVVLIPVDPNNPNGPKMPFRQYHAPFYGKTTKRFATQSEHFLADPPGLRSNADETAEYDDAVRVAIAMGGAQALNSTKRSPWQTAQGLYWAYDGSNLIGTPPRFYNQIVRRIAVTYKKEEDLANSEVNNADFARLFALVDVACTDAGIFSWKEKWEFEFWRPLSGVRDDGRPDHGDPFWLTLGAPATNTNDIPFKPPFPAYPSGHATFGGAVFQMVRRYYNGRVGTWKDDEPDNIAIDMMISEELNGVNRDLRQPYDPTAPIEDQPGIVRTRIVRHFDSAWELMFENAISRIFLGVHWRFDAAAARDILIPTTTKDVYAVDNNGATVFQNVEDIRYTTRGTREDEEGLFPIGGVPLGIEIADEIFNNGLKPTPPEIQPM 1vne A 2.15 BS01 VO4 A 1 K353 R360 S402 G403 H404 R490 H496 K350 R357 S399 G400 H401 R487 H493 K353 R360 S402 G403 H404 R490 H496 K350 R357 S399 G400 H401 R487 H493 1.11.1.10 0004601,0005576,0016691,0046872,0098869 P49053 10499093 610 VTPIPLPKIDEPEEYNTNYILFWNHVGLELNRVTHTVGGPLTGPPLSARALGMLHLAIHDAYFSICPPTDFTTFLSPDTENAAYRLPSPNGANDARQAVAGAALKMLSSLYMKPVEQPNPNPGANISDNAYAQLGLVLDRSVLEAPGGVDRESASFMFGEDVADVFFALLNDPRGASQEGYHPTPGRYKFDDEPTHPVVLIPVDPNNPNGPKMPFRQYHAPFYGKTTKRFATQSEHFLADPPGLRSNADETAEYDDAVRVAIAMGGAQALNSTKRSPWQTAQGLYWAYAGSNLIGTPPRFYNQIVRRIAVTYKKEEDLANSEVNNADFARLFALVDVACTDAGIFSWKEKWEFEFWRPLSGVRDDGRPDHGDPFWLTLGAPATNTNDIPFKPPFPAYPSGHATFGGAVFQMVRRYYNGRVGTWKDDEPDNIAIDMMISEELNGVNRDLRQPYDPTAPIEDQPGIVRTRIVRHFDSAWELMFENAISRIFLGVHWRFDAAAARDILIPTTTKDVYAVDNNGATVFQNVEDIRYTTRGTREDEEGLFPIGGVPLGIEIADEIFNNGLKPTPPEIQP 1vnf A 2.35 BS01 VO4 A 1 K353 S402 G403 H404 R490 H496 K350 S399 G400 H401 R487 H493 K353 A360 S402 G403 H404 R490 H496 K350 A357 S399 G400 H401 R487 H493 1.11.1.10 0004601,0005576,0016691,0046872,0098869 P49053 10499093 610 VTPIPLPKIDEPEEYNTNYILFWNHVGLELNRVTHTVGGPLTGPPLSARALGMLHLAIHDAYFSICPPTDFTTFLSPDTENAAYRLPSPNGANDARQAVAGAALKMLSSLYMKPVEQPNPNPGANISDNAYAQLGLVLDRSVLEAPGGVDRESASFMFGEDVADVFFALLNDPRGASQEGYHPTPGRYKFDDEPTHPVVLIPVDPNNPNGPKMPFRQYHAPFYGKTTKRFATQSEHFLADPPGLRSNADETAEYDDAVRVAIAMGGAQALNSTKRSPWQTAQGLYWAYDGSNLIGTPPRFYNQIVRRIAVTYKKEEDLANSEVNNADFARLFALVDVACTDAGIFSWKEKWEFEFWAPLSGVRDDGRPDHGDPFWLTLGAPATNTNDIPFKPPFPAYPSGHATFGGAVFQMVRRYYNGRVGTWKDDEPDNIAIDMMISEELNGVNRDLRQPYDPTAPIEDQPGIVRTRIVRHFDSAWELMFENAISRIFLGVHWRFDAAAARDILIPTTTKDVYAVDNNGATVFQNVEDIRYTTRGTREDEEGLFPIGGVPLGIEIADEIFNNGLKPTPPEIQP 1vng A 2.2 BS01 VO4 A 1 K353 S402 G403 A404 H496 K350 S399 G400 A401 H493 K353 R360 S402 G403 A404 R490 H496 K350 R357 S399 G400 A401 R487 H493 1.11.1.10 0004601,0005576,0016691,0046872,0098869 P49053 10499093 610 VTPIPLPKIDEPEEYNTNYILFWNHVGLELNRVTHTVGGPLTGPPLSARALGMLHLAIHDAYFSICPPTDFTTFLSPDTENAAYRLPSPNGANDARQAVAGAALKMLSSLYMKPVEQPNPNPGANISDNAYAQLGLVLDRSVLEAPGGVDRESASFMFGEDVADVFFALLNDPRGASQEGYHPTPGRYKFDDEPTHPVVLIPVDPNNPNGPKMPFRQYHAPFYGKTTKRFATQSEHFLADPPGLRSNADETAEYDDAVRVAIAMGGAQALNSTKRSPWQTAQGLYWAYDGSNLIGTPPRFYNQIVRRIAVTYKKEEDLANSEVNNADFARLFALVDVACTDAGIFSWKEKWEFEFWRPLSGVRDDGRPDHGDPFWLTLGAPATNTNDIPFKPPFPAYPSGAATFGGAVFQMVRRYYNGRVGTWKDDEPDNIAIDMMISEELNGVNRDLRQPYDPTAPIEDQPGIVRTRIVRHFDSAWELMFENAISRIFLGVHWRFDAAAARDILIPTTTKDVYAVDNNGATVFQNVEDIRYTTRGTREDEEGLFPIGGVPLGIEIADEIFNNGLKPTPPEIQP 1vnh A 2.11 BS01 VO4 A 1 K353 R360 F397 S402 G403 H404 R490 K350 R357 F394 S399 G400 H401 R487 K353 R360 S402 G403 H404 R490 A496 K350 R357 S399 G400 H401 R487 A493 1.11.1.10 0004601,0005576,0016691,0046872,0098869 P49053 10499093 610 VTPIPLPKIDEPEEYNTNYILFWNHVGLELNRVTHTVGGPLTGPPLSARALGMLHLAIHDAYFSICPPTDFTTFLSPDTENAAYRLPSPNGANDARQAVAGAALKMLSSLYMKPVEQPNPNPGANISDNAYAQLGLVLDRSVLEAPGGVDRESASFMFGEDVADVFFALLNDPRGASQEGYHPTPGRYKFDDEPTHPVVLIPVDPNNPNGPKMPFRQYHAPFYGKTTKRFATQSEHFLADPPGLRSNADETAEYDDAVRVAIAMGGAQALNSTKRSPWQTAQGLYWAYDGSNLIGTPPRFYNQIVRRIAVTYKKEEDLANSEVNNADFARLFALVDVACTDAGIFSWKEKWEFEFWRPLSGVRDDGRPDHGDPFWLTLGAPATNTNDIPFKPPFPAYPSGHATFGGAVFQMVRRYYNGRVGTWKDDEPDNIAIDMMISEELNGVNRDLRQPYDPTAPIEDQPGIVRTRIVRHFDSAWELMFENAISRIFLGVAWRFDAAAARDILIPTTTKDVYAVDNNGATVFQNVEDIRYTTRGTREDEEGLFPIGGVPLGIEIADEIFNNGLKPTPPEIQP 1vni A 2.15 BS01 VO4 A 1 K353 R360 S402 G403 H404 R490 H496 K350 R357 S399 G400 H401 R487 H493 K353 R360 S402 G403 H404 R490 H496 K350 R357 S399 G400 H401 R487 H493 1.11.1.10 0004601,0005576,0016691,0046872,0098869 P49053 10499093 610 VTPIPLPKIDEPEEYNTNYILFWNHVGLELNRVTHTVGGPLTGPPLSARALGMLHLAIHDAYFSICPPTDFTTFLSPDTENAAYRLPSPNGANDARQAVAGAALKMLSSLYMKPVEQPNPNPGANISDNAYAQLGLVLDRSVLEAPGGVDRESASFMFGEDVADVFFALLNDPRGASQEGYHPTPGRYKFDDEPTHPVVLIPVDPNNPNGPKMPFRQYHAPFYGKTTKRFATQSEHFLADPPGLRSNADETAEYDDAVRVAIAMGGAQALNSTKRSPWQTAQGLYWAYDGSNLIGTPPRFYNQIVRRIAVTYKKEEDLANSEVNNADFARLFALVDVACTDAGIFSWKEKWEFEFWRPLSGVRDDGRPDHGDPFWLTLGAPATNTNDIPFKPPFPAYPSGHATFGGAVFQMVRRYYNGRVGTWKDDEPDNIAIDMMISEELNGVNRDLRQPYDPTAPIEDQPGIVRTRIVRHFDSAWELMFENAISRIFLGVHWRFDAAAARDILIPTTTKDVYAVDNNGATVFQNVEDIRYTTRGTREDEEGLFPIGGVPLGIEIADEIFNNGLKPTPPEIQP 1vom A 1.9 BS02 VO4 A 1 S181 G182 K185 N233 S236 S237 S456 G457 S180 G181 K184 N228 S231 S232 S451 G452 S181 G182 T186 N233 S236 S237 G457 E459 S180 G181 T185 N228 S231 S232 G452 E454 ? 0003774,0005524,0016459,0051015 P08799 8611530 998 NPIHDRTSDYHKYLKVKQGDSDLFKLTVSDKRYIWYNPDPDERDSYECGEIVSETSDSFTFKTVDGQDRQVKKDDANQRNPIKFDGVEDMSELSYLNEPAVFHNLRVRYNQDLIYTYSGLFLVAVNPFKRIPIYTQEMVDIFKGRRRNEVAPHIFAISDVAYRSMLDDRQNQSLLITGESGAGKTENTKKVIQYLASVAGRNQGVLEQQILQANPILEAFGNAKTTRNNNSSRFGKFIEIQFNNAGFISGASIQSYLLEKSRVVFQSETERNYHIFYQLLAGATAEEKKALHLAGPESFNYLNQSGCVDIKGVSDEDEFKITRQAMDIVGFSQEEQMSIFKIIAGILHLGNIKFEKGAGEGAVLKDKTALNAASTVFGVNPSVLEKALMEPRILAGRDLVAQHLNVEKSSSSRDALVKALYGRLFLWLVKKINNVLCSERAAYFIGVLDISGFEIFKVNSFEQLCINYTNEKLQQFFNHHMFKVEQEEYLKEKINWTFIDFGLDSQATIDLIDGRQPPGILALLDEQSVFPNATDNTLITKLHSHFSKKNAKYEEPRFSKTEFGVTHYAGQVMYEIQDWLEKNKDPLQQDLELCFKDSSDNVVTKLFNDPNIASRAKKGANFITVAAQYKEQLASLMATLETTNPHFVRCIIPNNKQLPAKLEDKVVLDQLRCNGVLEGIRITRKGFPNRIIYADFVKRYYLLAPVPRDQKATNIDPEQYRFGITKIFFR 2azd A 2.16 BS04 VO4 A 1 R534 K539 R534 K539 H345 K533 R534 K539 T641 K645 H345 K533 R534 K539 T641 K645 2.4.1.1 0004645,0005737,0005829,0005975,0005980,0008184,0016757,0030170,0030980,0031220,0042803,0102250,0102499 P00490 18164678 999 SQPIFNDKQFQEALSRQWQRYGLNSAAEMTPRQWWLAVSEALAEMLRAQPFAKPVANQRHVNYISMEFLIGRLTGNNLLNLGWYQDVQDSLKAYDINLTDLLEEEIDPALGNGGLGRLAACFLDSMATVGQSATGYGLNYQYGLFRQSFVDGKQVEAPDDWHRSNYPWFRHNEALDVQVGIGGKVTKDGRWEPEFTITGQAWDLPVVGYRNGVAQPLRLWQATHAHPFDLTKFNDGDFLRAEQQGINAEKLTKVLYPNDNAFEGKKLRLMQQYFQCACSVADILRRHHLAGRKLHELADYEVIQLNDTHPTIAIPELLRVLIDEHQMSWDDAWAITSKTFAYTNHTLMPEALERWDVKLVKGLLPRHMQIINEINTRFKTLVEKTWPGDEKVWAKLAVVHDKQVHMANLCVVGGFAVNGVAALHSDLVVKDLFPEYHQLWPNKFHNVTNGITPRRWIKQCNPALAALLDKSLQKEWANDLDQLINLEKFADDAKFRQQYREIKQANKVRLAEFVKVRTGIEINPQAIFDIQIKRLHEYKRQHLNLLHILALYKEIRENPQADRVPRVFLFGAKAAPGYYLAKNIIFAINKVADVINNDPLVGDKLKVVFLPDYCVSAAEKLIPAADISEQISTAGKEASGTGNMKLALNGALTVGTLDGANVEIAEKVGEENIFIFGHTVEQVKAILAKGYDPVKWRKKDKVLDAVLKELESGKYSDGDKHAFDQMLHSIGKQGGDPYLVMADFAAYVEAQKQVDVLYRDQEAWTRAAILNTARCGMFSSDRSIRDYQARIWQAKR 2azd B 2.16 BS03 VO4 B 1 R534 K539 R534 K539 H345 K533 R534 K539 T641 K645 H345 K533 R534 K539 T641 K645 2.4.1.1 0004645,0005737,0005829,0005975,0005980,0008184,0016757,0030170,0030980,0031220,0042803,0102250,0102499 P00490 18164678 1999 SQPIFNDKQFQEALSRQWQRYGLNSAAEMTPRQWWLAVSEALAEMLRAQPFAKPVANQRHVNYISMEFLIGRLTGNNLLNLGWYQDVQDSLKAYDINLTDLLEEEIDPALGNGGLGRLAACFLDSMATVGQSATGYGLNYQYGLFRQSFVDGKQVEAPDDWHRSNYPWFRHNEALDVQVGIGGKVTKDGRWEPEFTITGQAWDLPVVGYRNGVAQPLRLWQATHAHPFDLTKFNDGDFLRAEQQGINAEKLTKVLYPNDNAFEGKKLRLMQQYFQCACSVADILRRHHLAGRKLHELADYEVIQLNDTHPTIAIPELLRVLIDEHQMSWDDAWAITSKTFAYTNHTLMPEALERWDVKLVKGLLPRHMQIINEINTRFKTLVEKTWPGDEKVWAKLAVVHDKQVHMANLCVVGGFAVNGVAALHSDLVVKDLFPEYHQLWPNKFHNVTNGITPRRWIKQCNPALAALLDKSLQKEWANDLDQLINLEKFADDAKFRQQYREIKQANKVRLAEFVKVRTGIEINPQAIFDIQIKRLHEYKRQHLNLLHILALYKEIRENPQADRVPRVFLFGAKAAPGYYLAKNIIFAINKVADVINNDPLVGDKLKVVFLPDYCVSAAEKLIPAADISEQISTAGKEASGTGNMKLALNGALTVGTLDGANVEIAEKVGEENIFIFGHTVEQVKAILAKGYDPVKWRKKDKVLDAVLKELESGKYSDGDKHAFDQMLHSIGKQGGDPYLVMADFAAYVEAQKQVDVLYRDQEAWTRAAILNTARCGMFSSDRSIRDYQARIWQAKR 2b9s A 2.27 BS04 VO4 B 1 R314 R410 H453 R288 R384 H423 5.6.2.1 0003677,0003917,0005694,0006265 Q9GPZ9 16487540 301 DLNWWEQENLRIAMKGERRWETLAHNGVLFPPEYEPHGIPIFYDGREFKMTPEEEEVATMFAVMKEHDYYRMEVFRRNFFESWREILDKRQHPIRRLELCDFEPIYQWHLVQREKKLSRTKEEKKAIKEKQDAEAEPYRYCVWDGRREQVANFRVEPPGLFRGRGKHPLMGKLKVRVQPEDITINIGETAEVPVPPAGHKWAAVQHDHTVTWLAMWRDSVAGNMKYVMLAPSSSVKGQSDMVKFEKARKLKDKVDDIRASYMEDFKSNDLHVAQRAVAMYFIDRLALRVGNEKGEDEADTVGCCSLRVEHIQLMPDNIVRFDFLGKDSIRYQNDVAVLPEVYALLQRFTRRKSPGMDIFDQLNPTQLNDHLKSFMDGLSAKVFRTYNASITLDRWFKEKPWSTADKLAYFNKANTEVAILCNHQKS 2d1g A 1.75 BS01 VO4 A 1 N44 H106 S175 D208 H287 H288 H350 N36 H98 S167 D200 H279 H280 H342 3.1.3.2 0016788 A0Q436 16899453 801 NSKPNDYGTLQKLFNNANTLKTTTPIKHVVIIFQENNSFDRYFGMYPNAKNPEGEPKFVAKENTPNVNGLTKQLLENNPNTKNPYRLDRNFQPCSQNHEYHQEISSFNGGLMNKFVEHGGHDNDTYKQNCDGQVMGYYDGNTVTALWNYAQNFALNDNTFGTTFGPSTPGALNLVAGANGPAMSPSGNLENIENNYIIDDPNPYYDDCSYGTSKSGDTNTAVAKITDGYNIGHYLTQKGITWGWFQGGFKPTSYSGKTAICDAMSTNKFGVKSRDYIPHHEPFNYWKETSNPHHLAPSDDKYIGSNDQANHQYDISEFWKALDQNNMPAVSYLKAPGYQDGHGGYSNPLDEQEWLVNTINRIQQSKDWDSTAIIIIYDDSDGDYDHVYSPKSQFSDIKGRQGYGPRLPMLVISPYAKANYVDHSLLNQASVLKFIEYNWGIGSVSKYSNDKYSNNILNMFDFNKEQKTLKLILDPKTGLVM 2d1g B 1.75 BS01 VO4 B 1 N44 H106 S175 D208 H287 H288 H350 N32 H94 S154 D187 H266 H267 H329 3.1.3.2 0016788 A0Q436 16899453 901 SKPNDYQKLFNNANTLKTTTPIKHVVIIFQENNSFDRYFGMYPNAKNPEGEPKFVAKENTPNVNGLTKQLLENNPNTKNPYRLDRNFQPCSQNHEYHQEISSFNGGLMNKFVEHGGCDGQVMGYYDGNTVTALWNYAQNFALNDNTFGTTFGPSTPGALNLVAGANGPAMSPSGNLENIENNYIIDDPNPYYDDCSYGTSKSGDTNTAVAKITDGYNIGHYLTQKGITWGWFQGGFKPTSYSGKTAICDAMSTNKFGVKSRDYIPHHEPFNYWKETSNPHHLAPSDDKYIGSNDQANHQYDISEFWKALDQNNMPAVSYLKAPGYQDGHGGYSNPLDEQEWLVNTINRIQQSKDWDSTAIIIIYDDSDGDYDHVYSPKSQFSDIKGRQGYGPRLPMLVISPYAKANYVDHSLLNQASVLKFIEYNWGIGSVSKYSNDKYSNNILNMFDFNKEQKTLKLILDPKTGLVMHHHH 2f43 B 3.0 BS01 VO4 B 1 A158 G159 K162 E188 Y311 A158 G159 K162 E188 Y311 K162 E188 R189 R356 K162 E188 R189 R356 7.1.2.2 0001525,0001889,0005509,0005524,0005737,0005739,0005743,0005886,0006629,0006754,0006898,0006933,0009631,0009986,0010042,0015986,0016020,0016887,0030228,0031966,0042288,0042645,0042776,0043531,0043532,0043536,0045121,0045259,0045261,0046034,0046933,0046961,0051453,0098761,1901653,1902600,1904643,1905242 P10719 16531409 601 SAAPKAGTATGQIVAVIGAVVDVQFDEGLPPILNALEVQGRESRLVLEVAQHLGESTVRTIAMDGTEGLVRGQKVLDSGAPIKIPVGPETLGRIMNVIGEPIDERGPIKTKQFAPIHAEAPEFIEMSVEQEILVTGIKVVDLLAPYAKGGKIGLFGGAGVGKTVLIMELINNVAKAHGGYSVFAGVGERTREGNDLYHEMIESGVINLKDATSKVALVYGQMNEPPGARARVALTGLTVAEYFRDQEGQDVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATDMGTMQERITTTKKGSITSVQAIYVPADDLTDPAPATTFAHLDATTVLSRAIAELGIYPAVDPLDSTSRIMDPNIVGSEHYDVARGVQKILQDYKSLQDIIAILGMDELSEERARKIQRFLSQPFQVAEVFTGHMGKLVPLKETIKGFQQILAGDYDHLPEQAFYMVGPIEEAVAKADKLAEEH 2gso A 1.3 BS03 VO4 A 1 D54 T90 D210 H258 H363 D11 T47 D167 H215 H320 16893180 1004 TPHALLLISIDGLRADMLDRGITPNLSHLAREGVRARWMAPSYPSLTFPNHYTLVTGLRPDHHGIVHNSMRDPTLGGFWLSKSEAVGDARWWGGEPVWVGVENTGQHAATWSWPGSEAAIKGVRPSQWRHYQKGVRLDTRVDAVRGWLATDGAQRNRLVTLYFEHVDEAGHDHGPESRQYADAVRAVDAAIGRLLAGMQRDGTRARTNIIVVSDHGMAEVAPGHAISVEDIAPPQIATAITDGQVIGFEPLPGQQAAAEASVLGAHDHYDCWRKAELPARWQYGSHPRIPSLVCQMHEGWDALFPDKLAKRAQRGTRGSHGYDPALPSMRAVFLAQGPDLAQGKTLPGFDNVDVYALMSRLLGIPAAPNDGNPATLLPALRM 2gso B 1.3 BS03 VO4 B 1 D54 T90 D210 H258 H363 D11 T47 D167 H215 H320 16893180 1005 TPHALLLISIDGLRADMLDRGITPNLSHLAREGVRARWMAPSYPSLTFPNHYTLVTGLRPDHHGIVHNSMRDPTLGGFWLSKSEAVGDARWWGGEPVWVGVENTGQHAATWSWPGSEAAIKGVRPSQWRHYQKGVRLDTRVDAVRGWLATDGAQRNRLVTLYFEHVDEAGHDHGPESRQYADAVRAVDAAIGRLLAGMQRDGTRARTNIIVVSDHGMAEVAPGHAISVEDIAPPQIATAITDGQVIGFEPLPGQQAAAEASVLGAHDHYDCWRKAELPARWQYGSHPRIPSLVCQMHEGWDALFPDKLAKRAQRGTRGSHGYDPALPSMRAVFLAQGPDLAQGKTLPGFDNVDVYALMSRLLGIPAAPNDGNPATLLPALRM 2i42 A 2.2 BS01 VO4 A 1 D356 C403 R404 A405 V407 G408 R409 Q446 D170 C217 R218 A219 V221 G222 R223 Q260 E290 W354 D356 H402 C403 R409 T410 E104 W168 D170 H216 C217 R223 T224 3.1.3.48 0004725,0006470,0016311 P15273 1 SPYGPEARAELSSRLTTLRNTLAPATNDPRYLQACGGEKLNRFRDIQCRRQTAVRADLNANYIQVGNTRTIACQYPLQSQLESHFRMLAENRTPVLAVLASSSEIANQRFGMPDYFRQSGTYGSITVESKMTQQVGLGDGIMADMYTLTIREAGQKTISVPVVHVGNWPDQTAVSSEVTKALASLVDQTAETKRNMYESKGSSAVADDSKLRPVIHCRAGVGRTAQLIGAMCMNDSRNSQLSVEDMVSQMRVQRNGIMVQKDEQLDVLIKLAEGQGRPLLNS 3f9b A 1.42 BS01 VO4 A 1 R278 S388 S389 R92 S202 S203 E290 F354 D356 H402 C403 R409 T410 E104 F168 D170 H216 C217 R223 T224 3.1.3.48 0004725,0006470,0016311 P15273 19140798 501 SPYGPEARAELSSRLTTLRNTLAPATNDPRYLQACGGEKLNRFRDIQCRRQTAVRADLNANYIQVGNTRTIACQYPLQSQLESHFRMLAENRTPVLAVLASSSEIANQRFGMPDYFRQSGTYGSITVESKMTQQVGLGDGIMADMYTLTIREAGQKTISVPVVHVGNFPDQTAVSSEVTKALASLVDQTAETKRNMYESKGSSAVADDSKLRPVIHCRAGVGRTAQLIGAMCMNDSRNSQLSVEDMVSQMRVQRNGIMVQKDEQLDVLIKLAEGQGRPLLNS 3gp5 A 2.25 BS01 VO4 A 1 R8 H9 N15 R60 E87 H182 G183 R8 H9 N15 R60 E87 H182 G183 H9 R60 E87 H182 H9 R60 E87 H182 5.4.2.11 0003824,0004619,0006094,0006096,0016853,0016868,0046538 Q3JWH7 21904048 251 MYKLVLIRHGESTWNKENRFTGWVDVDLTEQGNREARQAGQLLKEAGYTFDIAYTSVLKRAIRTLWHVQDQMDLMYVPVVHSWRLNERHYGALSGLNKAETAAKYGDEQVLVWRRSYDTPPPALEPGDERAPYADPRYAKVPREQLPLTECLKDTVARVLPLWNESIAPAVKAGKQVLIAAHGNSLRALIKYLDGISDADIVGLNIPNGVPLVYELDESLTPIRHYYLGDQEAIAKAQAAVAQQGKSA 3gp5 B 2.25 BS01 VO4 B 1 R8 H9 N15 R60 E87 H182 G183 R8 H9 N15 R60 E87 H182 G183 H9 R60 E87 H182 H9 R60 E87 H182 5.4.2.11 0003824,0004619,0006094,0006096,0016853,0016868,0046538 Q3JWH7 21904048 252 MYKLVLIRHGESTWNKENRFTGWVDVDLTEQGNREARQAGQLLKEAGYTFDIAYTSVLKRAIRTLWHVQDQMDLMYVPVVHSWRLNERHYGALSGLNKAETAAKYGDEQVLVWRRSYDTPPPALEPGDERAPYADPRYAKVPREQLPLTECLKDTVARVLPLWNESIAPAVKAGKQVLIAAHGNSLRALIKYLDGISDADIVGLNIPNGVPLVYELDESLTPIRHYYLG 3gw8 A 1.93 BS01 VO4 A 1 R8 H9 N15 R60 E87 H182 G183 R8 H9 N15 R60 E87 H182 G183 H9 R60 E87 H182 H9 R60 E87 H182 5.4.2.11 0003824,0004619,0006094,0006096,0016853,0016868,0046538 Q3JWH7 21904048 401 MYKLVLIRHGESTWNKENRFTGWVDVDLTEQGNREARQAGQLLKEAGYTFDIAYTSVLKRAIRTLWHVQDQMDLMYVPVVHSWRLNERHYGALSGLNKAETAAKYGDEQVLVWRRSYDTPPPALEPGDERAPYADPRYAKVPREQLPLTECLKDTVARVLPLWNESIAPAVKAGKQVLIAAHGNSLRALIKYLDGISDADIVGLNIPNGVPLVYELDESLTPIRHYYLGD 3gw8 A 1.93 BS02 VO4 A 2 F20 Y90 K98 F20 Y90 K98 H9 R60 E87 H182 H9 R60 E87 H182 5.4.2.11 0003824,0004619,0006094,0006096,0016853,0016868,0046538 Q3JWH7 21904048 403 MYKLVLIRHGESTWNKENRFTGWVDVDLTEQGNREARQAGQLLKEAGYTFDIAYTSVLKRAIRTLWHVQDQMDLMYVPVVHSWRLNERHYGALSGLNKAETAAKYGDEQVLVWRRSYDTPPPALEPGDERAPYADPRYAKVPREQLPLTECLKDTVARVLPLWNESIAPAVKAGKQVLIAAHGNSLRALIKYLDGISDADIVGLNIPNGVPLVYELDESLTPIRHYYLGD 3gw8 B 1.93 BS01 VO4 B 1 R8 H9 N15 R60 E87 H182 G183 R8 H9 N15 R60 E87 H182 G183 H9 R60 E87 H182 H9 R60 E87 H182 5.4.2.11 0003824,0004619,0006094,0006096,0016853,0016868,0046538 Q3JWH7 21904048 401 MYKLVLIRHGESTWNKENRFTGWVDVDLTEQGNREARQAGQLLKEAGYTFDIAYTSVLKRAIRTLWHVQDQMDLMYVPVVHSWRLNERHYGALSGLNKAETAAKYGDEQVLVWRRSYDTPPPALEPGDERAPYADPRYAKVPREQLPLTECLKDTVARVLPLWNESIAPAVKAGKQVLIAAHGNSLRALIKYLDGISDADIVGLNIPNGVPLVYELDESLTPIRHYYLGD 3gw8 B 1.93 BS02 VO4 B 2 Y90 K98 R114 N184 Y90 K98 R114 N184 H9 R60 E87 H182 H9 R60 E87 H182 5.4.2.11 0003824,0004619,0006094,0006096,0016853,0016868,0046538 Q3JWH7 21904048 403 MYKLVLIRHGESTWNKENRFTGWVDVDLTEQGNREARQAGQLLKEAGYTFDIAYTSVLKRAIRTLWHVQDQMDLMYVPVVHSWRLNERHYGALSGLNKAETAAKYGDEQVLVWRRSYDTPPPALEPGDERAPYADPRYAKVPREQLPLTECLKDTVARVLPLWNESIAPAVKAGKQVLIAAHGNSLRALIKYLDGISDADIVGLNIPNGVPLVYELDESLTPIRHYYLGD 3i7z A 2.3 BS02 VO4 A 1 C215 S216 A217 I219 G220 R221 C214 S215 A216 I218 G219 R220 D181 C215 R221 S222 Q262 D180 C214 R220 S221 Q261 3.1.3.48 0004725,0006470,0016311 IC50=2000nM P18031 20236928 322 EMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHED 3i80 A 2.25 BS01 VO4 A 1 D181 C215 S216 A217 G218 I219 G220 R221 Q262 D180 C214 S215 A216 G217 I218 G219 R220 Q261 D181 C215 R221 S222 Q262 D180 C214 R220 S221 Q261 3.1.3.48 0004725,0006470,0016311 IC50=2000nM P18031 20236928 322 EMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDL 3igc A 2.1 BS04 VO4 A 1 R130 R223 Y274 R130 R223 Y274 R130 K167 R223 H265 Y274 R130 K167 R223 H265 Y274 5.6.2.1 0003677,0003916,0003917,0006265,0044423 P32989 20152159 600 MRALFYKDGKLFTDNNFLNPVSDNNPAYEVLQHVKIPTHLTDVVVYGQTWEEALTRLIFVGSDSKGRRQYFYGKMHVQNRNAKRDRIFVRVYNVMKRINSFINKNIKKSSTDSNYQLAVFMLMETMFFIRFGKMKYLKENETVGLLTLKNKHIEISPDKIVIKFVGKDKVSHEFVVHKSNRLYKPLLKLTDDSSPEEFLFNKLSERKVYESIKQFGIRIKDLRTYGVNYTFLYNFWTNVKSISPLPSPKKLIALTIKQTAEVVGHTPSISKRAYMATTILEMVKDKNFLDVVSKTTFDEFLSIVVDHVKSSTD 3mgv B 2.29 BS04 VO4 B 1 R173 K201 H289 R292 W315 Y324 R154 K182 H270 R273 W296 Y305 ? 0003677,0006310,0015074 P06956 20462863 690 SDEVRKNLMDMFRDRQAFSEHTWKMLLSVCRSWAAWCKLNNRKWFPAEPEDVRDYLLYLQARGLAVKTIQQHLGQLNMLHRRSGLPRPSDSNAVSLVMRRIRKENVDAGERAKQALAFERTDFDQVRSLMENSDRCQDIRNLAFLGIAYNTLLRIAEIARIRVKDISRTDGGRMLIHIGRTKTLVSTAGVEKALSLGVTKLVERWISVSGVADDPNNYLFCRVRKNGVAAPSATSQLSTRALEGIFEATHRLIYGAKDDSGQRYLAWSGHSARVGAARDMARAGVSIPEIMQAGGWTNVNIVMNYIRNLDSETGAMVRLLED 3mgv D 2.29 BS04 VO4 D 1 R173 H289 R292 W315 Y324 R154 H270 R273 W296 Y305 ? 0003677,0006310,0015074 P06956 20462863 690 SDEVRKNLMDMFRDRQAFSEHTWKMLLSVCRSWAAWCKLNNRKWFPAEPEDVRDYLLYLQARGLAVKTIQQHLGQLNMLHRRSGLPRPSDSNAVSLVMRRIRKENVDAGERAKQALAFERTDFDQVRSLMENSDRCQDIRNLAFLGIAYNTLLRIAEIARIRVKDISRTDGGRMLIHIGRTKTLVSTAGVEKALSLGVTKLVERWISVSGVADDPNNYLFCRVRKNGVAAPSATSQLSTRALEGIFEATHRLIYGAKDDSGQRYLAWSGHSARVGAARDMARAGVSIPEIMQAGGWTNVNIVMNYIRNLDSETGAMVRLLED 3myh X 2.01 BS02 VO4 X 1 S181 G182 K185 N233 A236 S237 G457 S180 G181 K184 N226 A229 S230 G450 S181 T186 A236 S237 S180 T185 A229 S230 ? 0003774,0005524,0016459,0051015 P08799 20459085 998 NPIHDRTSDYHKYLKVKQGDSDLFKLTVSDKRYIWYNPDPKERDSYECGEIVSETSDSFTFKTVDGQDRQVKKDDANQRNPIKFDGVEDMSELSYLNEPAVFHNLRVRYNQDLIYTYSGLFLVAVNPFKRIPIYTQEMVDIFKGRRRNEVAPHIFAISDVAYRSMLDDRQNQSLLITGESGAGKTENTKKVIQYLASVAGRGVLEQQILQANPILEAFGNAKTTRNNNASRFGKFIEIQFNSAGFISGASIQSYLLEKSRVVFQSETERNYHIFYQLLAGATAEEKKALHLAGPESFNYLNQSGCVDIKGVSDSEEFKITRQAMDIVGFSQEEQMSIFKIIAGILHLGNIKFEKGAGEGAVLKDKTALNAASTVFGVNPSVLEKALMEPRILAGRDLVAQHLNVEKSSSSRDALVKALYGRLFLWLVKKINNVLCQERKAYFIGVLDISGFEIFKVNSFEQLCINYTNEKLQQFFNHHMFKLEQEEYLKEKINWTFIDFGLDSQATIDLIDGRQPPGILALLDEQSVFPNATDNTLITKLHSHFSKKNAKYEEPRFSKTEFGVTHYAGQVMYEIQDWLEKNKDPLQQDLELCFKDSSDNVVTKLFNDPNIASRAKKGANFITVAAQYKEQLASLMATLETTNPHFVRCIIPNNKQLPAKLEDKVVLDQLRCNGVLEGIRITRKGFPNRIIYADDPEQYRFGITKIFFR 3omx A 2.3366 BS01 VO4 A 1 C13 S14 S15 M17 N18 R19 D144 C8 S9 S10 M12 N13 R14 D139 3.1.3.16 0004721,0004722,0005634,0005847,0006357,0006369,0006397,0008420,0016791,0017018,0031124 Q9VWE4 21204787 300 KLAVAVVCSSNMNRSMEAHNFLAKKGFNVRSYGTGERVKLPGMAFDKPNVYEFGTKYEDIYRDLESKDKEFYTQNGLLHMLDRNRRIKKCPERFQDTKEQFDIIVTVEERVYDLVVMHMESMESVDNRPVHVLNVDVVDNAEDALMGAFVITDMINMMAKSTDLDNDIDELIQEFEERRKRVILHSVLFY 3omx B 2.3366 BS01 VO4 B 1 C13 S14 S15 M17 N18 R19 D144 C8 S9 S10 M12 N13 R14 D139 3.1.3.16 0004721,0004722,0005634,0005847,0006357,0006369,0006397,0008420,0016791,0017018,0031124 Q9VWE4 21204787 300 KLAVAVVCSSNMNRSMEAHNFLAKKGFNVRSYGTGERVKLPGMAFDKPNVYEFGTKYEDIYRDLESKDKEFYTQNGLLHMLDRNRRIKKCPERFQDTKEQFDIIVTVEERVYDLVVMHMESMESVDNRPVHVLNVDVVDNAEDALMGAFVITDMINMMAKSTDLDNDIDELIQEFEERRKRVILHSVLFY 3omx C 2.3366 BS01 VO4 C 1 C13 S14 S15 N16 M17 N18 R19 D144 C8 S9 S10 N11 M12 N13 R14 D139 3.1.3.16 0004721,0004722,0005634,0005847,0006357,0006369,0006397,0008420,0016791,0017018,0031124 Q9VWE4 21204787 300 KLAVAVVCSSNMNRSMEAHNFLAKKGFNVRSYGTGERVKLPGMAFDKPNVYEFGTKYEDIYRDLESKDKEFYTQNGLLHMLDRNRRIKKCPERFQDTKEQFDIIVTVEERVYDLVVMHMESMESVDNRPVHVLNVDVVDNAEDALMGAFVITDMINMMAKSTDLDNDIDELIQEFEERRKRVILHSVLFY 3omx D 2.3366 BS01 VO4 D 1 C13 S14 S15 M17 N18 R19 D144 C8 S9 S10 M12 N13 R14 D139 3.1.3.16 0004721,0004722,0005634,0005847,0006357,0006369,0006397,0008420,0016791,0017018,0031124 Q9VWE4 21204787 300 KLAVAVVCSSNMNRSMEAHNFLAKKGFNVRSYGTGERVKLPGMAFDKPNVYEFGTKYEDIYRDLESKDKEFYTQNGLLHMLDRNRRIKKCPERFQDTKEQFDIIVTVEERVYDLVVMHMESMESVDNRPVHVLNVDVVDNAEDALMGAFVITDMINMMAKSTDLDNDIDELIQEFEERRKRVILHSVLFY 3q8y A 2.7 BS02 VO4 A 1 K9 R102 H115 G116 K9 R102 H115 G116 K9 Y49 N112 H115 E126 K9 Y49 N112 H115 E126 2.7.4.6 0004550,0005524,0005737,0006183,0006228,0006241,0009117,0009142,0016301,0016310,0046872 Q5HFV4 21745603 159 MERTFLMIKPDAVQRNLIGEVISRIERKGLKLVGGKLMQVPMELAETHYGEHQGKPFYNDLISFITSAPVFAMVVEGEDAVNVSRHIIGSTNPSEASPGSIRGDLGLTVGRNIIHGSDSLESAEREINLWFNENEITSYASPRDAWLYE 3q8y B 2.7 BS02 VO4 B 1 K9 H115 G116 K9 H115 G116 K9 Y49 N112 H115 E126 K9 Y49 N112 H115 E126 2.7.4.6 0004550,0005524,0005737,0006183,0006228,0006241,0009117,0009142,0016301,0016310,0046872 Q5HFV4 21745603 159 MERTFLMIKPDAVQRNLIGEVISRIERKGLKLVGGKLMQVPMELAETHYGEHQGKPFYNDLISFITSAPVFAMVVEGEDAVNVSRHIIGSTNPSEASPGSIRGDLGLTVGRNIIHGSDSLESAEREINLWFNENEITSYASPRDAWLYE 3q8y C 2.7 BS01 VO4 C 1 K9 H115 G116 K9 H115 G116 K9 Y49 N112 H115 E126 K9 Y49 N112 H115 E126 2.7.4.6 0004550,0005524,0005737,0006183,0006228,0006241,0009117,0009142,0016301,0016310,0046872 Q5HFV4 21745603 158 MERTFLMIKPDAVQRNLIGEVISRIERKGLKLVGGKLMQVPMELAETHYGEHQGKPFYNDLISFITSAPVFAMVVEGEDAVNVSRHIIGSTNPSEASPGSIRGDLGLTVGRNIIHGSDSLESAEREINLWFNENEITSYASPRDAWLYE 3q8y D 2.7 BS02 VO4 D 1 K9 Y49 H115 K9 Y49 H115 K9 Y49 N112 H115 E126 K9 Y49 N112 H115 E126 2.7.4.6 0004550,0005524,0005737,0006183,0006228,0006241,0009117,0009142,0016301,0016310,0046872 Q5HFV4 21745603 159 MERTFLMIKPDAVQRNLIGEVISRIERKGLKLVGGKLMQVPMELAETHYGEHQGKPFYNDLISFITSAPVFAMVVEGEDAVNVSRHIIGSTNPSEASPGSIRGDLGLTVGRNIIHGSDSLESAEREINLWFNENEITSYASPRDAWLYE 3q8y E 2.7 BS02 VO4 E 1 K9 Y49 H115 G116 K9 Y49 H115 G116 K9 Y49 N112 H115 E126 K9 Y49 N112 H115 E126 2.7.4.6 0004550,0005524,0005737,0006183,0006228,0006241,0009117,0009142,0016301,0016310,0046872 Q5HFV4 21745603 159 MERTFLMIKPDAVQRNLIGEVISRIERKGLKLVGGKLMQVPMELAETHYGEHQGKPFYNDLISFITSAPVFAMVVEGEDAVNVSRHIIGSTNPSEASPGSIRGDLGLTVGRNIIHGSDSLESAEREINLWFNENEITSYASPRDAWLYE 3q8y F 2.7 BS01 VO4 F 1 K9 Y49 H115 K9 Y49 H115 K9 Y49 N112 H115 E126 K9 Y49 N112 H115 E126 2.7.4.6 0004550,0005524,0005737,0006183,0006228,0006241,0009117,0009142,0016301,0016310,0046872 Q5HFV4 21745603 158 MERTFLMIKPDAVQRNLIGEVISRIERKGLKLVGGKLMQVPMELAETHYGEHQGKPFYNDLISFITSAPVFAMVVEGEDAVNVSRHIIGSTNPSEASPGSIRGDLGLTVGRNIIHGSDSLESAEREINLWFNENEITSYASPRDAWLYE 3q8y G 2.7 BS02 VO4 G 1 K9 Y49 H115 G116 K9 Y49 H115 G116 K9 Y49 N112 H115 E126 K9 Y49 N112 H115 E126 2.7.4.6 0004550,0005524,0005737,0006183,0006228,0006241,0009117,0009142,0016301,0016310,0046872 Q5HFV4 21745603 159 MERTFLMIKPDAVQRNLIGEVISRIERKGLKLVGGKLMQVPMELAETHYGEHQGKPFYNDLISFITSAPVFAMVVEGEDAVNVSRHIIGSTNPSEASPGSIRGDLGLTVGRNIIHGSDSLESAEREINLWFNENEITSYASPRDAWLYE 3q8y H 2.7 BS02 VO4 H 1 K9 H115 G116 K9 H115 G116 K9 Y49 N112 H115 E126 K9 Y49 N112 H115 E126 2.7.4.6 0004550,0005524,0005737,0006183,0006228,0006241,0009117,0009142,0016301,0016310,0046872 Q5HFV4 21745603 159 MERTFLMIKPDAVQRNLIGEVISRIERKGLKLVGGKLMQVPMELAETHYGEHQGKPFYNDLISFITSAPVFAMVVEGEDAVNVSRHIIGSTNPSEASPGSIRGDLGLTVGRNIIHGSDSLESAEREINLWFNENEITSYASPRDAWLYE 3rnt A 1.8 BS01 VO4 A 1 Y38 H40 E58 R77 H92 F100 Y38 H40 E58 R77 H92 F100 Y38 H40 E58 D76 R77 T91 H92 F100 Y38 H40 E58 D76 R77 T91 H92 F100 4.6.1.24 0001411,0003723,0004519,0004521,0004540,0008150,0016829,0030428,0046589 P00651 2514790 106 ACDYTCGSNCYSSSDVSTAQAAGYKLHEDGETVGSNSYPHKYNNYEGFDFSVSSPYYEWPILSSGDVYSGGSPGADRVVFNENNQLAGVITHTGASGNNFVECT 3w36 A 1.97 BS01 VO4 A 1 K372 R379 H420 S425 G426 S427 R488 H494 K319 R326 H367 S372 G373 S374 R435 H441 1.11.1.10 0004601,0098869 A7KH27 35985031 600 IEFDLDKDNYIKWAQPTDENAGQSPTLAILGPMDVTVFLWINRVVWLAAFDALAPYHETAVGVYSQIPRRPSSESATNRNLNIAALHAQHGVWKRVLPQQVDQLRELMTALGLDPSDETENLSSPVGIGNVAAKNAFNALKNDGMNFLGYEGRKYNPRPWADYTGYEPVNTAFKVNNPSRWQPQLQAHNARRAGGGPGDLGIYVTQHFVTPQTARTKAHIFRDPSRFRIPRPEFSDHTNTRAYKRSVDEIIDASANLNDERKALAEIMENKLWGIGHSSIVIANKYDQNNEMGVHGWCHWMLAHVLATFEPLIAAWHHKTRFDAVRPVTAIRHVYGNRKIRAWGGVGMGTVDIRASEWSSYLPVGDHPEYPSGSTSLCSATSQAARRYFDSDELDWTINYPAGSTVVEPGITPGKDLSIHIPTWTDFTRTCATSRVWGGVHFQTTVDRTIDFGEQFGDLAHEFVQRHVKG 3w36 B 1.97 BS01 VO4 B 1 K372 R379 H420 S425 G426 S427 R488 H494 K318 R325 H366 S371 G372 S373 R434 H440 1.11.1.10 0004601,0098869 A7KH27 35985031 600 EFDLDKDNYIKWAQPTDENAGQSPTLAILGPMDVTVFLWINRVVWLAAFDALAPYHETAVGVYSQIPRRPSSESATNRNLNIAALHAQHGVWKRVLPQQVDQLRELMTALGLDPSDETENLSSPVGIGNVAAKNAFNALKNDGMNFLGYEGRKYNPRPWADYTGYEPVNTAFKVNNPSRWQPQLQAHNARRAGGGPGDLGIYVTQHFVTPQTARTKAHIFRDPSRFRIPRPEFSDHTNTRAYKRSVDEIIDASANLNDERKALAEIMENKLWGIGHSSIVIANKYDQNNEMGVHGWCHWMLAHVLATFEPLIAAWHHKTRFDAVRPVTAIRHVYGNRKIRAWGGVGMGTVDIRASEWSSYLPVGDHPEYPSGSTSLCSATSQAARRYFDSDELDWTINYPAGSTVVEPGITPGKDLSIHIPTWTDFTRTCATSRVWGGVHFQTTVDRTIDFGEQFGDLAHEFVQRHVKGDV 4cit A 1.8 BS01 VO4 A 1 R331 S358 R410 H416 R294 S321 R373 H379 1.11.1.- 0004601,0098869 G0LAH5 25261522 1449 KEEPINITPEELDASIDRVTEIMIHDIFSPPVASRIFAYPNVAAYEIVAATNDNYNSLAGQLNGLTAIPEPDTTKTINYELAAVVAHMELSKRLIFSEDRMESLRDSLYMVWEGKNPVLFSDSKAYGLQVADHIGEWMNKDNYAQTRTMPKDPGRWQPTPPAYMDGIEPHWNKIRPFVLDSAAQFKPVPPPAYSLEEDSAFYKELKEVYDVRNKITEEGDSSEEIQIARFWDCNPYVSKKITPGAHWMGIAKIAARKTNSDFAKTLFAYTKASVAMADAFISCWDEKYRSNLIRPETVINQHIDDSWKPVLQTPPFPEYTSGHSVVSGAASVVLTEVFGDNFSFDDDTEVPYGLPIRSFKSFKQAADEAAISRMYGGIHYRAAIEVGVKQGRDLGTFVVNKLHMLSDKKV 4cit A 1.8 BS02 VO4 A 2 S358 H360 R410 H416 S321 H323 R373 H379 1.11.1.- 0004601,0098869 G0LAH5 25261522 1451 KEEPINITPEELDASIDRVTEIMIHDIFSPPVASRIFAYPNVAAYEIVAATNDNYNSLAGQLNGLTAIPEPDTTKTINYELAAVVAHMELSKRLIFSEDRMESLRDSLYMVWEGKNPVLFSDSKAYGLQVADHIGEWMNKDNYAQTRTMPKDPGRWQPTPPAYMDGIEPHWNKIRPFVLDSAAQFKPVPPPAYSLEEDSAFYKELKEVYDVRNKITEEGDSSEEIQIARFWDCNPYVSKKITPGAHWMGIAKIAARKTNSDFAKTLFAYTKASVAMADAFISCWDEKYRSNLIRPETVINQHIDDSWKPVLQTPPFPEYTSGHSVVSGAASVVLTEVFGDNFSFDDDTEVPYGLPIRSFKSFKQAADEAAISRMYGGIHYRAAIEVGVKQGRDLGTFVVNKLHMLSDKKV 4cit A 1.8 BS03 VO4 A 3 K324 S358 H416 K287 S321 H379 1.11.1.- 0004601,0098869 G0LAH5 25261522 1452 KEEPINITPEELDASIDRVTEIMIHDIFSPPVASRIFAYPNVAAYEIVAATNDNYNSLAGQLNGLTAIPEPDTTKTINYELAAVVAHMELSKRLIFSEDRMESLRDSLYMVWEGKNPVLFSDSKAYGLQVADHIGEWMNKDNYAQTRTMPKDPGRWQPTPPAYMDGIEPHWNKIRPFVLDSAAQFKPVPPPAYSLEEDSAFYKELKEVYDVRNKITEEGDSSEEIQIARFWDCNPYVSKKITPGAHWMGIAKIAARKTNSDFAKTLFAYTKASVAMADAFISCWDEKYRSNLIRPETVINQHIDDSWKPVLQTPPFPEYTSGHSVVSGAASVVLTEVFGDNFSFDDDTEVPYGLPIRSFKSFKQAADEAAISRMYGGIHYRAAIEVGVKQGRDLGTFVVNKLHMLSDKKV 4cit A 1.8 BS04 VO4 A 4 R331 H416 R294 H379 1.11.1.- 0004601,0098869 G0LAH5 25261522 1453 KEEPINITPEELDASIDRVTEIMIHDIFSPPVASRIFAYPNVAAYEIVAATNDNYNSLAGQLNGLTAIPEPDTTKTINYELAAVVAHMELSKRLIFSEDRMESLRDSLYMVWEGKNPVLFSDSKAYGLQVADHIGEWMNKDNYAQTRTMPKDPGRWQPTPPAYMDGIEPHWNKIRPFVLDSAAQFKPVPPPAYSLEEDSAFYKELKEVYDVRNKITEEGDSSEEIQIARFWDCNPYVSKKITPGAHWMGIAKIAARKTNSDFAKTLFAYTKASVAMADAFISCWDEKYRSNLIRPETVINQHIDDSWKPVLQTPPFPEYTSGHSVVSGAASVVLTEVFGDNFSFDDDTEVPYGLPIRSFKSFKQAADEAAISRMYGGIHYRAAIEVGVKQGRDLGTFVVNKLHMLSDKKV 4dz6 B 2.2 BS01 VO4 B 1 K13 Y53 H134 A135 K12 Y52 H133 A134 K13 Y53 N131 H134 E145 K12 Y52 N130 H133 E144 2.7.4.6 0004550,0005524,0005737,0005829,0006183,0006228,0006241,0009117,0016301,0016310,0046872 O51419 29870023 201 SMLLQKTLCIVKPDGVRRGLIGDVVSRFERVGLKMVAAKMLIVDESLAKKHYLYDDIVFRHSEAVWNSLIKFISNSPVFTFVVEGVESIEVVRKLCGATEPKLAIPGTIRGDFSYHSFKYSNEKGFSIYNVIHASANEADAMREIPIWFKDNEILNYKRDDECEHYYC 4dz6 E 2.2 BS01 VO4 E 1 K13 H134 A135 K12 H133 A134 K13 Y53 N131 H134 E145 K12 Y52 N130 H133 E144 2.7.4.6 0004550,0005524,0005737,0005829,0006183,0006228,0006241,0009117,0016301,0016310,0046872 O51419 29870023 201 SMLLQKTLCIVKPDGVRRGLIGDVVSRFERVGLKMVAAKMLIVDESLAKKHYLYDDIVFRHSEAVWNSLIKFISNSPVFTFVVEGVESIEVVRKLCGATEPKLAIPGTIRGDFSYHSFKYSNEKGFSIYNVIHASANEADAMREIPIWFKDNEILNYKRDDECEHYYC 4dz6 F 2.2 BS01 VO4 F 1 K13 Y53 H134 A135 K12 Y52 H133 A134 K13 Y53 N131 H134 E145 K12 Y52 N130 H133 E144 2.7.4.6 0004550,0005524,0005737,0005829,0006183,0006228,0006241,0009117,0016301,0016310,0046872 O51419 29870023 201 SMLLQKTLCIVKPDGVRRGLIGDVVSRFERVGLKMVAAKMLIVDESLAKKHYLYDDIVFRHSEAVWNSLIKFISNSPVFTFVVEGVESIEVVRKLCGATEPKLAIPGTIRGDFSYHSFKYSNEKGFSIYNVIHASANEADAMREIPIWFKDNEILNYKRDDECEHYYC 4usz A 2.0 BS01 VO4 A 1 K324 R331 F353 S358 G359 H360 R410 H416 K293 R300 F322 S327 G328 H329 R379 H385 1.11.1.- 0004601,0098869 G0LAH5 25261522 1447 KEEPINITPEELDASIDRVTEIMIHDIFSPPVASRIFAYPNVAAYEIVAATNDNYNSLAGQLNGLTAIPEPDTTKTINYELAAVVAHMELSKRLIFSEDRMESLRDSLYMVWEGKNPVLFSDSKAYGLQVADHIGEWMNKDNYAQTRTMPKFTVDADDPGRWQPTPPAYMDGIEPHWNKIRPFVLDSAAQFKPVPPPAYSLEEDSAFYKELKEVYDVRNKITEEGDSSEEIQIARFWDCNPYVSKKITPGAHWMGIAKIAARKTNSDFAKTLFAYTKASVAMADAFISCWDEKYRSNLIRPETVINQHIDDSWKPVLQTPPFPEYTSGHSVVSGAASVVLTEVFGDNFSFDDDTEVPYGLPIRSFKSFKQAADEAAISRMYGGIHYRAAIEVGVKQGRDLGTFVVNKLHMLSDKK 4zi4 A 1.121 BS02 VO4 A 1 R278 K342 S388 S389 R92 K156 S202 S203 E290 H354 D356 H402 C403 R409 T410 E104 H168 D170 H216 C217 R223 T224 3.1.3.48 0004725,0006470,0016311 P15273 26445170 502 SPYGPEARAELSSRLTTLRNTLAPATNDPRYLQACGGEKLNRFRDIQCRRQTAVRADLNANYIQVGNTRTIACQYPLQSQLESHFRMLAENRTPVLAVLASSSEIANQRFGMPDYFRQSGTYGSITVESKMTQQVGLGDGIMADMYTLTIREAGQKTISVPVVHVGNHPDQTAVSSEVTKALASLVDQTAETKRNMYESKGSSAVADDSKLRPVIHCRAGVGRTAQLIGAMCMNDSRNSQLSVEDMVSQMRVQRNGIMVQKDEQLDVLIKLAEGQGRPLLNS 4zn5 A 1.12 BS02 VO4 A 1 R278 K342 S388 S389 R92 K156 S202 S203 E290 Y354 D356 H402 C403 R409 T410 E104 Y168 D170 H216 C217 R223 T224 3.1.3.48 0004725,0006470,0016311 P15273 26445170 502 SPYGPEARAELSSRLTTLRNTLAPATNDPRYLQACGGEKLNRFRDIQCRRQTAVRADLNANYIQVGNTRTIACQYPLQSQLESHFRMLAENRTPVLAVLASSSEIANQRFGMPDYFRQSGTYGSITVESKMTQQVGLGDGIMADMYTLTIREAGQKTISVPVVHVGNYPDQTAVSSEVTKALASLVDQTAETKRNMYESKGSSAVADDSKLRPVIHCRAGVGRTAQLIGAMCMNDSRNSQLSVEDMVSQMRVQRNGIMVQKDEQLDVLIKLAEGQGRPLLNS 5aa6 A 2.26 BS01 VO4 A 1 K374 R382 P442 H444 S449 G450 H451 R530 H536 K353 R361 P420 H422 S427 G428 H429 R508 H514 K374 R382 H444 S449 G450 H451 R530 H536 D540 K353 R361 H422 S427 G428 H429 R508 H514 D518 1.11.1.18 0004601,0098869 K7ZUA3 800 QTVNELADMQTRPLLSGSVCRVRDTVDFLSPTKRAKITFKRRIGIAVGELAVGPTCHLNNGDEANIPLFDGQFHKSLPHDDMGRVNPEAYQLLLDCIESNDINVCDQVPSGVESDGRKLVNPLGGGGHQVDGADSDNIFIKQPDNLLSERLAAQQAEVYWMALLRDIPFSQFGTNNTVQMAVVNLQGFDAFNGLSISRDADGNIDPMQDLFRTDWPGVSSGPMVSQFMLANFDIDGIVVEPKAKTLVPEMEYMTGVDTWLNIQNGGPPEDTLFVDEPLFIRNGRDLAALSFNDVLYTEAFRTILIMFNESILAEAGPYGSSTRQEGFTTLGTSHYIHAMAAGSSSTRHAWYAKWQVHRVLRPEAYGGLLHFVINIDDVPLPASIVSNTELLNAVESLNQAQNGGTNQVFLLPMAVGEGSPVHPAYPSGHAINLGAYLTVLKAFLGFELGQRCFPSPMISNDAGTDRIPFVPSDGDRVGTCINEDGEEEVGLTYEGELNKVTSNVAIGRSHLGVHWRMDGVFGAEMGEAGAIRRLQQELGGLPEARDTEGPIPPASYKFRLYSGTMIELFPDNRYMLGDQMCKGFFTGDDFCVPA 5aa6 B 2.26 BS01 VO4 B 1 K374 R382 H444 S449 G450 H451 R530 H536 K353 R361 H422 S427 G428 H429 R508 H514 K374 R382 H444 S449 G450 H451 R530 H536 D540 K353 R361 H422 S427 G428 H429 R508 H514 D518 1.11.1.18 0004601,0098869 K7ZUA3 800 QTVNELADMQTRPLLSGSVCRVRDTVDFLSPTKRAKITFKRRIGIAVGELAVGPTCHLNNGDEANIPLFDGQFHKSLPHDDMGRVNPEAYQLLLDCIESNDINVCDQVPSGVESDGRKLVNPLGGGGHQVDGADSDNIFIKQPDNLLSERLAAQQAEVYWMALLRDIPFSQFGTNNTVQMAVVNLQGFDAFNGLSISRDADGNIDPMQDLFRTDWPGVSSGPMVSQFMLANFDIDGIVVEPKAKTLVPEMEYMTGVDTWLNIQNGGPPEDTLFVDEPLFIRNGRDLAALSFNDVLYTEAFRTILIMFNESILAEAGPYGSSTRQEGFTTLGTSHYIHAMAAGSSSTRHAWYAKWQVHRVLRPEAYGGLLHFVINIDDVPLPASIVSNTELLNAVESLNQAQNGGTNQVFLLPMAVGEGSPVHPAYPSGHAINLGAYLTVLKAFLGFELGQRCFPSPMISNDAGTDRIPFVPSDGDRVGTCINEDGEEEVGLTYEGELNKVTSNVAIGRSHLGVHWRMDGVFGAEMGEAGAIRRLQQELGGLPEARDTEGPIPPASYKFRLYSGTMIELFPDNRYMLGDQMCKGFFTGDDFCVPAD 5aa6 C 2.26 BS01 VO4 C 1 K374 R382 P442 H444 S449 G450 H451 R530 H536 K353 R361 P420 H422 S427 G428 H429 R508 H514 K374 R382 H444 S449 G450 H451 R530 H536 D540 K353 R361 H422 S427 G428 H429 R508 H514 D518 1.11.1.18 0004601,0098869 K7ZUA3 800 QTVNELADMQTRPLLSGSVCRVRDTVDFLSPTKRAKITFKRRIGIAVGELAVGPTCHLNNGDEANIPLFDGQFHKSLPHDDMGRVNPEAYQLLLDCIESNDINVCDQVPSGVESDGRKLVNPLGGGGHQVDGADSDNIFIKQPDNLLSERLAAQQAEVYWMALLRDIPFSQFGTNNTVQMAVVNLQGFDAFNGLSISRDADGNIDPMQDLFRTDWPGVSSGPMVSQFMLANFDIDGIVVEPKAKTLVPEMEYMTGVDTWLNIQNGGPPEDTLFVDEPLFIRNGRDLAALSFNDVLYTEAFRTILIMFNESILAEAGPYGSSTRQEGFTTLGTSHYIHAMAAGSSSTRHAWYAKWQVHRVLRPEAYGGLLHFVINIDDVPLPASIVSNTELLNAVESLNQAQNGGTNQVFLLPMAVGEGSPVHPAYPSGHAINLGAYLTVLKAFLGFELGQRCFPSPMISNDAGTDRIPFVPSDGDRVGTCINEDGEEEVGLTYEGELNKVTSNVAIGRSHLGVHWRMDGVFGAEMGEAGAIRRLQQELGGLPEARDTEGPIPPASYKFRLYSGTMIELFPDNRYMLGDQMCKGFFTGDDFCVPA 5aa6 D 2.26 BS01 VO4 D 1 K374 R382 P442 H444 S449 G450 H451 R530 H536 K353 R361 P420 H422 S427 G428 H429 R508 H514 K374 R382 H444 S449 G450 H451 R530 H536 D540 K353 R361 H422 S427 G428 H429 R508 H514 D518 1.11.1.18 0004601,0098869 K7ZUA3 800 QTVNELADMQTRPLLSGSVCRVRDTVDFLSPTKRAKITFKRRIGIAVGELAVGPTCHLNNGDEANIPLFDGQFHKSLPHDDMGRVNPEAYQLLLDCIESNDINVCDQVPSGVESDGRKLVNPLGGGGHQVDGADSDNIFIKQPDNLLSERLAAQQAEVYWMALLRDIPFSQFGTNNTVQMAVVNLQGFDAFNGLSISRDADGNIDPMQDLFRTDWPGVSSGPMVSQFMLANFDIDGIVVEPKAKTLVPEMEYMTGVDTWLNIQNGGPPEDTLFVDEPLFIRNGRDLAALSFNDVLYTEAFRTILIMFNESILAEAGPYGSSTRQEGFTTLGTSHYIHAMAAGSSSTRHAWYAKWQVHRVLRPEAYGGLLHFVINIDDVPLPASIVSNTELLNAVESLNQAQNGGTNQVFLLPMAVGEGSPVHPAYPSGHAINLGAYLTVLKAFLGFELGQRCFPSPMISNDAGTDRIPFVPSDGDRVGTCINEDGEEEVGLTYEGELNKVTSNVAIGRSHLGVHWRMDGVFGAEMGEAGAIRRLQQELGGLPEARDTEGPIPPASYKFRLYSGTMIELFPDNRYMLGDQMCKGFFTGDDFCVPA 5aa6 E 2.26 BS01 VO4 E 1 K374 R382 P442 H444 S449 G450 H451 R530 H536 K353 R361 P420 H422 S427 G428 H429 R508 H514 K374 R382 H444 S449 G450 H451 R530 H536 D540 K353 R361 H422 S427 G428 H429 R508 H514 D518 1.11.1.18 0004601,0098869 K7ZUA3 800 QTVNELADMQTRPLLSGSVCRVRDTVDFLSPTKRAKITFKRRIGIAVGELAVGPTCHLNNGDEANIPLFDGQFHKSLPHDDMGRVNPEAYQLLLDCIESNDINVCDQVPSGVESDGRKLVNPLGGGGHQVDGADSDNIFIKQPDNLLSERLAAQQAEVYWMALLRDIPFSQFGTNNTVQMAVVNLQGFDAFNGLSISRDADGNIDPMQDLFRTDWPGVSSGPMVSQFMLANFDIDGIVVEPKAKTLVPEMEYMTGVDTWLNIQNGGPPEDTLFVDEPLFIRNGRDLAALSFNDVLYTEAFRTILIMFNESILAEAGPYGSSTRQEGFTTLGTSHYIHAMAAGSSSTRHAWYAKWQVHRVLRPEAYGGLLHFVINIDDVPLPASIVSNTELLNAVESLNQAQNGGTNQVFLLPMAVGEGSPVHPAYPSGHAINLGAYLTVLKAFLGFELGQRCFPSPMISNDAGTDRIPFVPSDGDRVGTCINEDGEEEVGLTYEGELNKVTSNVAIGRSHLGVHWRMDGVFGAEMGEAGAIRRLQQELGGLPEARDTEGPIPPASYKFRLYSGTMIELFPDNRYMLGDQMCKGFFTGDDFCVPA 5aa6 F 2.26 BS01 VO4 F 1 K374 R382 H444 S449 G450 H451 R530 H536 K353 R361 H422 S427 G428 H429 R508 H514 K374 R382 H444 S449 G450 H451 R530 H536 D540 K353 R361 H422 S427 G428 H429 R508 H514 D518 1.11.1.18 0004601,0098869 K7ZUA3 800 QTVNELADMQTRPLLSGSVCRVRDTVDFLSPTKRAKITFKRRIGIAVGELAVGPTCHLNNGDEANIPLFDGQFHKSLPHDDMGRVNPEAYQLLLDCIESNDINVCDQVPSGVESDGRKLVNPLGGGGHQVDGADSDNIFIKQPDNLLSERLAAQQAEVYWMALLRDIPFSQFGTNNTVQMAVVNLQGFDAFNGLSISRDADGNIDPMQDLFRTDWPGVSSGPMVSQFMLANFDIDGIVVEPKAKTLVPEMEYMTGVDTWLNIQNGGPPEDTLFVDEPLFIRNGRDLAALSFNDVLYTEAFRTILIMFNESILAEAGPYGSSTRQEGFTTLGTSHYIHAMAAGSSSTRHAWYAKWQVHRVLRPEAYGGLLHFVINIDDVPLPASIVSNTELLNAVESLNQAQNGGTNQVFLLPMAVGEGSPVHPAYPSGHAINLGAYLTVLKAFLGFELGQRCFPSPMISNDAGTDRIPFVPSDGDRVGTCINEDGEEEVGLTYEGELNKVTSNVAIGRSHLGVHWRMDGVFGAEMGEAGAIRRLQQELGGLPEARDTEGPIPPASYKFRLYSGTMIELFPDNRYMLGDQMCKGFFTGDDFCVPA 7bcw A 3.5 BS01 VO4 A 1 S378 K382 H537 S373 K377 H532 7.5.2.6 0005524,0005886,0006869,0008289,0008559,0015437,0015920,0016020,0016887,0034040,0034204,0042802,0042908,0043190,0055085,0140359,1990199 P60752 34921499 601 DLSTWQTFRRLWPTIAPFKAGLIVAGVALILNAASDTFMLSLLKPLLDDGFGKTDRSVLVWMPLVVIGLMILRGITSYVSSYCISWVSGKVVMTMRRRLFGHMMGMPVSFFDKQSTGTLLSRITYDSEQVASSSSGALITVVREGASIIGLFIMMFYYSWQLSIILIVLAPIVSIAIRVVSKRFRNISKNMQNTMGQVTTSAEQMLKGHKEVLIFGGQEVETKRFDKVSNRMRLQGMKMVSASSISDPIIQLIASLALAFVLYAASFPSVMDSLTAGTITVVFSSMIALMRPLKSLTNVNAQFQRGMAACQTLFTILDSEQEKDEGKRVIERATGDVEFRNVTFTYPGRDVPALRNINLKIPAGKTVALVGRSGSGKSTIASLITRFYDIDEGEILMDGHDLREYTLASLRNQVALVSQNVHLFNDTVANNIAYARTEQYSREQIEEAARMAYAMDFINKMDNGLDTVIGENGVLLSGGQRQRIAIARALLRDSPILILDEATSALDTESERAIQAALDELQKNRTSLVIAHRLSTIEKADEIVVVEDGVIVERGTHNDLLEHRGVYAQLHKMQ 7bcw A 3.5 BS04 VO4 B 1 S482 A510 S477 A505 7.5.2.6 0005524,0005886,0006869,0008289,0008559,0015437,0015920,0016020,0016887,0034040,0034204,0042802,0042908,0043190,0055085,0140359,1990199 P60752 34921499 601 DLSTWQTFRRLWPTIAPFKAGLIVAGVALILNAASDTFMLSLLKPLLDDGFGKTDRSVLVWMPLVVIGLMILRGITSYVSSYCISWVSGKVVMTMRRRLFGHMMGMPVSFFDKQSTGTLLSRITYDSEQVASSSSGALITVVREGASIIGLFIMMFYYSWQLSIILIVLAPIVSIAIRVVSKRFRNISKNMQNTMGQVTTSAEQMLKGHKEVLIFGGQEVETKRFDKVSNRMRLQGMKMVSASSISDPIIQLIASLALAFVLYAASFPSVMDSLTAGTITVVFSSMIALMRPLKSLTNVNAQFQRGMAACQTLFTILDSEQEKDEGKRVIERATGDVEFRNVTFTYPGRDVPALRNINLKIPAGKTVALVGRSGSGKSTIASLITRFYDIDEGEILMDGHDLREYTLASLRNQVALVSQNVHLFNDTVANNIAYARTEQYSREQIEEAARMAYAMDFINKMDNGLDTVIGENGVLLSGGQRQRIAIARALLRDSPILILDEATSALDTESERAIQAALDELQKNRTSLVIAHRLSTIEKADEIVVVEDGVIVERGTHNDLLEHRGVYAQLHKMQ 7bcw B 3.5 BS01 VO4 A 1 S482 G483 G484 A510 S477 G478 G479 A505 7.5.2.6 0005524,0005886,0006869,0008289,0008559,0015437,0015920,0016020,0016887,0034040,0034204,0042802,0042908,0043190,0055085,0140359,1990199 P60752 34921499 601 DLSTWQTFRRLWPTIAPFKAGLIVAGVALILNAASDTFMLSLLKPLLDDGFGKTDRSVLVWMPLVVIGLMILRGITSYVSSYCISWVSGKVVMTMRRRLFGHMMGMPVSFFDKQSTGTLLSRITYDSEQVASSSSGALITVVREGASIIGLFIMMFYYSWQLSIILIVLAPIVSIAIRVVSKRFRNISKNMQNTMGQVTTSAEQMLKGHKEVLIFGGQEVETKRFDKVSNRMRLQGMKMVSASSISDPIIQLIASLALAFVLYAASFPSVMDSLTAGTITVVFSSMIALMRPLKSLTNVNAQFQRGMAACQTLFTILDSEQEKDEGKRVIERATGDVEFRNVTFTYPGRDVPALRNINLKIPAGKTVALVGRSGSGKSTIASLITRFYDIDEGEILMDGHDLREYTLASLRNQVALVSQNVHLFNDTVANNIAYARTEQYSREQIEEAARMAYAMDFINKMDNGLDTVIGENGVLLSGGQRQRIAIARALLRDSPILILDEATSALDTESERAIQAALDELQKNRTSLVIAHRLSTIEKADEIVVVEDGVIVERGTHNDLLEHRGVYAQLHKMQ 7bcw B 3.5 BS03 VO4 B 1 S378 K382 Q424 E506 H537 S373 K377 Q419 E501 H532 7.5.2.6 0005524,0005886,0006869,0008289,0008559,0015437,0015920,0016020,0016887,0034040,0034204,0042802,0042908,0043190,0055085,0140359,1990199 P60752 34921499 601 DLSTWQTFRRLWPTIAPFKAGLIVAGVALILNAASDTFMLSLLKPLLDDGFGKTDRSVLVWMPLVVIGLMILRGITSYVSSYCISWVSGKVVMTMRRRLFGHMMGMPVSFFDKQSTGTLLSRITYDSEQVASSSSGALITVVREGASIIGLFIMMFYYSWQLSIILIVLAPIVSIAIRVVSKRFRNISKNMQNTMGQVTTSAEQMLKGHKEVLIFGGQEVETKRFDKVSNRMRLQGMKMVSASSISDPIIQLIASLALAFVLYAASFPSVMDSLTAGTITVVFSSMIALMRPLKSLTNVNAQFQRGMAACQTLFTILDSEQEKDEGKRVIERATGDVEFRNVTFTYPGRDVPALRNINLKIPAGKTVALVGRSGSGKSTIASLITRFYDIDEGEILMDGHDLREYTLASLRNQVALVSQNVHLFNDTVANNIAYARTEQYSREQIEEAARMAYAMDFINKMDNGLDTVIGENGVLLSGGQRQRIAIARALLRDSPILILDEATSALDTESERAIQAALDELQKNRTSLVIAHRLSTIEKADEIVVVEDGVIVERGTHNDLLEHRGVYAQLHKMQ 7mpc A 1.75 BS01 VO4 A 1 D69 C96 V97 G98 I100 G101 R102 D69 C96 V97 G98 I100 G101 R102 ? 0004725,0005737,0006470,0016311,0016787 Q97VZ7 34496202 201 MYWVRRKTIGGSGLPYTENEILEWRKEGVKRVLVLPEDWEIEESWGDKDYYLSILKKNGLQPLHIPIPDGGVPSDSQFLTIMKWLLSEKEGNLVHCVGGIGRTGTILASYLILTEGLEVESAIDEVRLVRPGAVQTYEQEMFLLRVEGMRKSWLKNIYSN 7znu A 4.0 BS02 VO4 A 1 T370 Q416 E497 H528 T370 Q416 E497 H528 7.5.2.3 0005515,0005524,0005886,0006869,0015441,0015775,0016020,0016887,0034040,0043621,0055085,0140359 Q2YQ73 36456825 602 MSLLKIYWRAMQYLAVERTATITMCVASVLVALVTLAEPVLFGRVIQSISDKGDIFSPLLMWAALGGFNIMAAVFVARGADRLAHRRRLGVMIDSYERLITMPLAWHQKRGTSNALHTLIRATDSLFTLWLEFMRQHLTTVVALATLIPVAMTMDMRMSLVLIVLGVIYVMIGQLVMRKTKDGQAAVEKHHHKLFEHVSDTISNVSVVQSYNRIASETQALRDYAKNLENAQFPVLNWWALASGLNRMASTFSMVVVLVLGAYFVTKGQMRVGDVIAFIGFAQLMIGRLDQISAFINQTVTARAKLEEFFQMEDATADRQEPENVADLNDVKGDIVFDNVTYEFPNSGQGVYDVSFEVKPGQTVAIVGPTGAGKTTLINLLQRVFDPAAGRIMIDGTDTRTVSRRSLRHAIATVFQDAGLFNRSVEDNIRVGRANATHEEVHAAAKAAAAHDFILAKSEGYDTFVGERGSQLSGGERQRLAIARAILKDSPILVLDEATSALDVETEEKVTQAVDELSHNRTTFIIAHRLSTVRSADLVLFMDKGHLVESGSFNEL 7znu B 4.0 BS03 VO4 B 1 T370 Q416 H528 T370 Q416 H528 7.5.2.3 0005515,0005524,0005886,0006869,0015441,0015775,0016020,0016887,0034040,0043621,0055085,0140359 Q2YQ73 36456825 602 MSLLKIYWRAMQYLAVERTATITMCVASVLVALVTLAEPVLFGRVIQSISDKGDIFSPLLMWAALGGFNIMAAVFVARGADRLAHRRRLGVMIDSYERLITMPLAWHQKRGTSNALHTLIRATDSLFTLWLEFMRQHLTTVVALATLIPVAMTMDMRMSLVLIVLGVIYVMIGQLVMRKTKDGQAAVEKHHHKLFEHVSDTISNVSVVQSYNRIASETQALRDYAKNLENAQFPVLNWWALASGLNRMASTFSMVVVLVLGAYFVTKGQMRVGDVIAFIGFAQLMIGRLDQISAFINQTVTARAKLEEFFQMEDATADRQEPENVADLNDVKGDIVFDNVTYEFPNSGQGVYDVSFEVKPGQTVAIVGPTGAGKTTLINLLQRVFDPAAGRIMIDGTDTRTVSRRSLRHAIATVFQDAGLFNRSVEDNIRVGRANATHEEVHAAAKAAAAHDFILAKSEGYDTFVGERGSQLSGGERQRLAIARAILKDSPILVLDEATSALDVETEEKVTQAVDELSHNRTTFIIAHRLSTVRSADLVLFMDKGHLVESGSFNEL 7zo9 A 3.5 BS02 VO4 A 1 K374 Q416 H528 K374 Q416 H528 7.5.2.3 0005515,0005524,0005886,0006869,0015441,0015775,0016020,0016887,0034040,0043621,0055085,0140359 Q2YQ73 36456825 602 MSLLKIYWRAMQYLAVERTATITMCVASVLVALVTLAEPVLFGRVIQSISDKGDIFSPLLMWAALGGFNIMAAVFVARGADRLAHRRRLGVMIDSYERLITMPLAWHQKRGTSNALHTLIRATDSLFTLWLEFMRQHLTTVVALATLIPVAMTMDMRMSLVLIVLGVIYVMIGQLVMRKTKDGQAAVEKHHHKLFEHVSDTISNVSVVQSYNRIASETQALRDYAKNLENAQFPVLNWWALASGLNRMASTFSMVVVLVLGAYFVTKGQMRVGDVIAFIGFAQLMIGRLDQISAFINQTVTARAKLEEFFQMEDATADRQEPENVADLNDVKGDIVFDNVTYEFPNSGQGVYDVSFEVKPGQTVAIVGPTGAGKTTLINLLQRVFDPAAGRIMIDGTDTRTVSRRSLRHAIATVFQDAGLFNRSVEDNIRVGRANATHEEVHAAAKAAAAHDFILAKSEGYDTFVGERGSQLSGGERQRLAIARAILKDSPILVLDEATSALDVETEEKVTQAVDELSHNRTTFIIAHRLSTVRSADLVLFMDKGHLVESGSFNEL 7zo9 B 3.5 BS02 VO4 B 1 K374 Q416 H528 K374 Q416 H528 7.5.2.3 0005515,0005524,0005886,0006869,0015441,0015775,0016020,0016887,0034040,0043621,0055085,0140359 Q2YQ73 36456825 602 MSLLKIYWRAMQYLAVERTATITMCVASVLVALVTLAEPVLFGRVIQSISDKGDIFSPLLMWAALGGFNIMAAVFVARGADRLAHRRRLGVMIDSYERLITMPLAWHQKRGTSNALHTLIRATDSLFTLWLEFMRQHLTTVVALATLIPVAMTMDMRMSLVLIVLGVIYVMIGQLVMRKTKDGQAAVEKHHHKLFEHVSDTISNVSVVQSYNRIASETQALRDYAKNLENAQFPVLNWWALASGLNRMASTFSMVVVLVLGAYFVTKGQMRVGDVIAFIGFAQLMIGRLDQISAFINQTVTARAKLEEFFQMEDATADRQEPENVADLNDVKGDIVFDNVTYEFPNSGQGVYDVSFEVKPGQTVAIVGPTGAGKTTLINLLQRVFDPAAGRIMIDGTDTRTVSRRSLRHAIATVFQDAGLFNRSVEDNIRVGRANATHEEVHAAAKAAAAHDFILAKSEGYDTFVGERGSQLSGGERQRLAIARAILKDSPILVLDEATSALDVETEEKVTQAVDELSHNRTTFIIAHRLSTVRSADLVLFMDKGHLVESGSFNEL 8pmj A 2.81 BS05 VO4 A 1 S560 G562 A588 S1115 K1119 Q1161 H1275 S481 G483 A509 S931 K935 Q977 H1091 7.6.2.- 0000139,0005515,0005524,0005768,0005886,0006631,0006699,0006805,0006855,0006869,0006979,0008206,0008559,0009410,0009986,0014070,0015125,0015126,0015144,0015432,0015721,0015722,0016020,0016323,0016324,0016567,0016887,0031998,0034219,0042632,0043627,0045177,0045471,0046581,0046618,0046691,0055037,0055038,0055085,0055088,0055091,0070062,0071466,0120189,0140359,1904251 O95342 37949847 1507 RVGFFQLFRFSSSTDIWLMFVGSLCAFLHGIAQPGVLLIFGTMTDVFIDYDVELQELRCGLLNIESEMIKFASYYAGIAVAVLITGYIQICFWVIAAARQIQKMRKFYFRRIMRMEIGWFDCNSVGELNTRFSDDINKINDAIADQMALFIQRMTSTICGFLLGFFRGWKLTLVIISVSPLIGIGAATIGLSVSKFTDYELKAYAKAGVVADEVISSMRTVAAFGGEKREVERYEKNLVFAQRWGIRKGIVMGFFTGFVWCLIFLCYALAFWYGSTPGTLVQIFLSVIVGALNLGNASPCLEAFATGRAAATSIFETIDRKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGREDATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAMVQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVEREPAPVRRILKFSAPEWPYMLVGSVGAAVNGTVTPLYAFLFSQILGTEEQRSQINGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWFDDLRNSPGALTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKLSLVILCFFPFLALSGATQTRMLTGFASRDKQALEMVGQITNEALSNIRTVAGIGKERRFIEALETELEKPFKTAIQKANIYGFCFAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRVISAVVLSATALGRAFSYTPSYAKAKISAARFFQLLDRQPPISVYNTAGEKWDNFQGKIDFVDCKFTYPSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYKLVTTG 9ex0 A 1.45 BS03 VO4 A 1 N46 D52 N46 D52 0003796,0005515,0005576,0005615,0005737,0005783,0016231,0016798,0016998,0031640,0042742,0042802,0050829,0050830,0051672 P00698 38842919 204 KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL 9ex2 A 1.172 BS02 VO4 A 1 A10 K13 L129 A10 K13 L129 0003796,0005515,0005576,0005615,0005737,0005783,0016231,0016798,0016998,0031640,0042742,0042802,0050829,0050830,0051672 P00698 38842919 202 KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL 9ex2 A 1.172 BS05 VO4 A 2 N46 D52 N46 D52 0003796,0005515,0005576,0005615,0005737,0005783,0016231,0016798,0016998,0031640,0042742,0042802,0050829,0050830,0051672 P00698 38842919 205 KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL 9ex2 A 1.172 BS06 VO4 A 3 R14 H15 D87 T89 R14 H15 D87 T89 0003796,0005515,0005576,0005615,0005737,0005783,0016231,0016798,0016998,0031640,0042742,0042802,0050829,0050830,0051672 P00698 38842919 206 KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL