7jup A 3.05 BS01 VKM A 1 L707 L708 W711 Q851 R852 I858 R975 Q979 L243 L244 W247 Q361 R362 I368 R485 Q489 ? 0005216,0006811,0016020,0055085 IC50=5.60nM O75762 33749283 1101 SPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHLALHNKRKEVVLTIIRSKRWDECLKIFSHNSPGNKCPITEMIEYLPECMKVLLDFCMLHSTEDKSCRDYYIEYNFKYLQCLTALNAMVQNNRIELLNHPVCKEYLLMKWLAYGFRAHMMNLGSYCLGLIPMTILVVNIKPGMAFNSTGIINNSYLIKTCMILVFLSSIFGYCKEISNVLEWIIYTTGIIFVLPLFVEIPAHLQWQCGAIAVYFYWMNFLLYLQRFENCGIFIVMLEVILKTLLRSTVVFIFLLLAFGLSFYILLNLQDPFSSPLLSIIQTFSMMLGDINYRESFLEPYLRNELAHPVLSFAQLVSFTIFVPIVLMNLLIGLAVGDIADVQKHASLKRIAMQVELHTSLEKKLPLWFLRKVDQKSTIVYPSLEMEILKQKYRLKDLTFLLEKQHELIKLIIQKMEIISET 7jup B 3.05 BS01 VKM B 1 L707 L708 W711 Q851 R852 E854 I858 A971 R975 Q979 H983 L243 L244 W247 Q361 R362 E364 I368 A481 R485 Q489 H493 ? 0005216,0006811,0016020,0055085 IC50=5.60nM O75762 33749283 1101 SPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHLALHNKRKEVVLTIIRSKRWDECLKIFSHNSPGNKCPITEMIEYLPECMKVLLDFCMLHSTEDKSCRDYYIEYNFKYLQCLTALNAMVQNNRIELLNHPVCKEYLLMKWLAYGFRAHMMNLGSYCLGLIPMTILVVNIKPGMAFNSTGIINNSYLIKTCMILVFLSSIFGYCKEISNVLEWIIYTTGIIFVLPLFVEIPAHLQWQCGAIAVYFYWMNFLLYLQRFENCGIFIVMLEVILKTLLRSTVVFIFLLLAFGLSFYILLNLQDPFSSPLLSIIQTFSMMLGDINYRESFLEPYLRNELAHPVLSFAQLVSFTIFVPIVLMNLLIGLAVGDIADVQKHASLKRIAMQVELHTSLEKKLPLWFLRKVDQKSTIVYPSLEMEILKQKYRLKDLTFLLEKQHELIKLIIQKMEIISET 7jup C 3.05 BS01 VKM C 1 L707 L708 W711 Q851 E854 I858 R975 M978 Q979 H983 L243 L244 W247 Q361 E364 I368 R485 M488 Q489 H493 ? 0005216,0006811,0016020,0055085 IC50=5.60nM O75762 33749283 1101 SPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHLALHNKRKEVVLTIIRSKRWDECLKIFSHNSPGNKCPITEMIEYLPECMKVLLDFCMLHSTEDKSCRDYYIEYNFKYLQCLTALNAMVQNNRIELLNHPVCKEYLLMKWLAYGFRAHMMNLGSYCLGLIPMTILVVNIKPGMAFNSTGIINNSYLIKTCMILVFLSSIFGYCKEISNVLEWIIYTTGIIFVLPLFVEIPAHLQWQCGAIAVYFYWMNFLLYLQRFENCGIFIVMLEVILKTLLRSTVVFIFLLLAFGLSFYILLNLQDPFSSPLLSIIQTFSMMLGDINYRESFLEPYLRNELAHPVLSFAQLVSFTIFVPIVLMNLLIGLAVGDIADVQKHASLKRIAMQVELHTSLEKKLPLWFLRKVDQKSTIVYPSLEMEILKQKYRLKDLTFLLEKQHELIKLIIQKMEIISET 7jup D 3.05 BS01 VKM D 1 L708 W711 Q851 E854 I858 R975 M978 Q979 L982 L244 W247 Q361 E364 I368 R485 M488 Q489 L492 ? 0005216,0006811,0016020,0055085 IC50=5.60nM O75762 33749283 1101 SPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHLALHNKRKEVVLTIIRSKRWDECLKIFSHNSPGNKCPITEMIEYLPECMKVLLDFCMLHSTEDKSCRDYYIEYNFKYLQCLTALNAMVQNNRIELLNHPVCKEYLLMKWLAYGFRAHMMNLGSYCLGLIPMTILVVNIKPGMAFNSTGIINNSYLIKTCMILVFLSSIFGYCKEISNVLEWIIYTTGIIFVLPLFVEIPAHLQWQCGAIAVYFYWMNFLLYLQRFENCGIFIVMLEVILKTLLRSTVVFIFLLLAFGLSFYILLNLQDPFSSPLLSIIQTFSMMLGDINYRESFLEPYLRNELAHPVLSFAQLVSFTIFVPIVLMNLLIGLAVGDIADVQKHASLKRIAMQVELHTSLEKKLPLWFLRKVDQKSTIVYPSLEMEILKQKYRLKDLTFLLEKQHELIKLIIQKMEIISET