7jou A 3.318 BS01 VFS A 1 I82 G85 A86 G88 E89 V90 A103 K105 E154 Y155 M156 L205 D216 I74 G77 A78 G80 E81 V82 A95 K97 E146 Y147 M148 L197 D208 D198 K200 N203 D216 T237 D190 K192 N195 D208 T229 2.7.11.1 0004672,0004674,0005524,0006468 IC50=9.61nM Q13464 32798651 4000 TRFEKMDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEEDKGEEETFPIPKAFVGNQLPFVGFTYYSN 7jov A 2.586 BS01 VFS A 1 I98 G101 G104 E105 V106 A119 K121 M169 E170 Y171 M172 L221 A231 D232 I74 G77 G80 E81 V82 A95 K97 M145 E146 Y147 M148 L197 A207 D208 D214 K216 N219 D232 T253 D190 K192 N195 D208 T223 2.7.11.1 0004672,0004674,0005524,0006468 IC50=2.90nM O75116 32798651 502 SRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHTPDYISPEVLKFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDIDSSNFDDIEDVETFPIPKAFVGNQLPFIGFTYYR 7jov B 2.586 BS01 VFS B 1 I98 G101 G104 E105 V106 A119 K121 M169 E170 Y171 M172 L221 A231 D232 I76 G79 G82 E83 V84 A97 K99 M147 E148 Y149 M150 L199 A209 D210 D214 K216 N219 D232 D192 K194 N197 D210 2.7.11.1 0004672,0004674,0005524,0006468 IC50=2.90nM O75116 32798651 501 GASRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVPDYISPEVLKSDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDIDSSNFDDIVETFPIPKAFVGNQLPFIGFTYYR 7jov C 2.586 BS01 VFS C 1 I98 G104 E105 V106 A119 K121 M169 E170 Y171 M172 L221 D232 I76 G82 E83 V84 A97 K99 M147 E148 Y149 M150 L199 D210 D214 K216 N219 D232 T253 D192 K194 N197 D210 T229 2.7.11.1 0004672,0004674,0005524,0006468 IC50=2.90nM O75116 32798651 501 GASRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTGTPDYISPEVLKSQGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDIDSSNFDDIEDDVETFPIPKAFVGNQLPFIGFTYYR 7jov D 2.586 BS01 VFS D 1 I98 G104 E105 V106 A119 K121 M169 E170 Y171 M172 L221 A231 D232 I74 G80 E81 V82 A95 K97 M145 E146 Y147 M148 L197 A207 D208 D214 K216 N219 D232 D190 K192 N195 D208 2.7.11.1 0004672,0004674,0005524,0006468 IC50=2.90nM O75116 32798651 501 SRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDYISPEVLFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDIDSSNFDDIVETFPIPKAFVGNQLPFIGFTYYR 7jov E 2.586 BS01 VFS E 1 I98 G101 G104 E105 V106 A119 K121 M169 Y171 M172 L221 D232 I76 G79 G82 E83 V84 A97 K99 M147 Y149 M150 L199 D210 D214 K216 N219 D232 T253 D192 K194 N197 D210 T228 2.7.11.1 0004672,0004674,0005524,0006468 IC50=2.90nM O75116 32798651 501 GASRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDIDSSNFDDIVETFPIPKAFVGNQLPFIGFTYYR 7jov F 2.586 BS01 VFS F 1 I98 G101 G104 E105 V106 A119 K121 M169 E170 Y171 M172 L221 D232 I74 G77 G80 E81 V82 A95 K97 M145 E146 Y147 M148 L197 D208 D214 K216 N219 D232 T253 D190 K192 N195 D208 T229 2.7.11.1 0004672,0004674,0005524,0006468 IC50=2.90nM O75116 32798651 502 SRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDIDSSNFDDIEDVETFPIPKAFVGNQLPFIGFTYYR 7jov G 2.586 BS01 VFS G 1 I98 G101 E105 V106 A119 K121 M169 E170 Y171 M172 L221 D232 I76 G79 E83 V84 A97 K99 M147 E148 Y149 M150 L199 D210 D214 K216 N219 D232 T253 D192 K194 N197 D210 T228 2.7.11.1 0004672,0004674,0005524,0006468 IC50=2.90nM O75116 32798651 501 GASRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDIDSSNFDDIEDVETFPIPKAFVGNQLPFIGFTYYR 7jov H 2.586 BS01 VFS H 1 I98 G101 G104 E105 V106 A119 K121 M169 E170 Y171 M172 L221 A231 D232 I74 G77 G80 E81 V82 A95 K97 M145 E146 Y147 M148 L197 A207 D208 D214 K216 N219 D232 T253 D190 K192 N195 D208 T229 2.7.11.1 0004672,0004674,0005524,0006468 IC50=2.90nM O75116 32798651 501 SRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDIDSSNFDDIEDDVETFPIPKAFVGNQLPFIGFTYYR