1g9r A 2.0 BS02 UPF A 1 A6 A7 D8 Y11 H78 I79 S80 T83 R86 D103 I104 D105 N153 A154 Q187 D188 Q189 H244 C246 G247 K250 A6 A7 D8 Y11 H78 I79 S80 T83 R86 D103 I104 D105 N153 A154 Q187 D188 Q189 H240 C242 G243 K246 H78 D103 D105 D130 D188 Q189 H244 K250 H78 D103 D105 D130 D188 Q189 H240 K246 2.4.1.- 0016740,0016757,0046872 Ki=2uM -logKd/Ki=5.70, Ki=2uM Q93EK7 11175908 401 MDIVFAADDNYAAYLCVAAKSVEAAHPDTEIRFHVLDAGISEANRAAVAANLRGGGGNIRFIDVNPEDFAGFPLNIRHISITTYARLKLGEYIADCDKVLYLDIDVLVRDSLTPLWDTDLGDNWLGASIDLFVERQEGYKQKIGMADGEYYFNAGVLLINLKKWRRHDIFKMSSEWVEQYKDVMQYQDQDILNGLFKGGVCYANSRFNFMPTNYAFMASRHTDPLYRDRTNTVMPVAVSHYCGPAKPWHRDCTAWGAERFTELAGSLTTVPEEWRGKL 1ga8 A 2.0 BS03 UPF A 1 A6 A7 D8 Y11 H78 I79 S80 T83 R86 D103 I104 D105 N153 G155 Q187 D188 Q189 H244 C246 G247 K250 A6 A7 D8 Y11 H78 I79 S80 T83 R86 D103 I104 D105 N153 G155 Q187 D188 Q189 H240 C242 G243 K246 H78 D103 D105 D130 D188 Q189 H244 K250 H78 D103 D105 D130 D188 Q189 H240 K246 2.4.1.44 0016740,0016757,0046872 Ki=2uM Q93EK7 11175908 501 MDIVFAADDNYAAYLCVAAKSVEAAHPDTEIRFHVLDAGISEANRAAVAANLRGGGGNIRFIDVNPEDFAGFPLNIRHISITTYARLKLGEYIADCDKVLYLDIDVLVRDSLTPLWDTDLGDNWLGASIDLFVERQEGYKQKIGMADGEYYFNAGVLLINLKKWRRHDIFKMSSEWVEQYKDVMQYQDQDILNGLFKGGVCYANSRFNFMPTNYAFMASRHTDPLYRDRTNTVMPVAVSHYCGPAKPWHRDCTAWGAERFTELAGSLTTVPEEWRGKL 1ss9 A 2.6 BS02 UPF A 1 A6 D8 Y11 H78 I79 S80 T83 D103 D105 N153 G155 Q187 E189 H244 G247 K250 A6 D8 Y11 H78 I79 S80 T83 D103 D105 N153 G155 Q187 E189 H242 G245 K248 H78 D103 D105 D130 D188 E189 H244 K250 H78 D103 D105 D130 D188 E189 H242 K248 2.4.1.44 0016740,0016757,0046872 Q93EK7 15075344 401 MDIVFAADDNYAAYLCVAAKSVEAAHPDTEIRFHVLDAGISEANRAAVAANLRGGGGNIRFIDVNPEDFAGFPLNIRHISITTYARLKLGEYIADCDKVLYLDIDVLVRDSLTPLWDTDLGDNWLGACIDLFVERQEGYKQKIGMADGEYYFNAGVLLINLKKWRRHDIFKMSCEWVEQYKDVMQYQDEDILNGLFKGGVCYANSRFNFMPTNYAFMANASRHTDPLYRDRTNTVMPVAVSHYCGPAKPWHRDCTAWGAERFTELAGSLTTVPEEWRGKL 2vfz A 2.4 BS01 UPF A 1 F134 V136 Y139 I198 S199 R202 D225 V226 D227 H280 A281 A282 D316 E317 K359 F53 V55 Y58 I117 S118 R121 D144 V145 D146 H199 A200 A201 D235 E236 K278 W314 W233 2.4.1.87 0005975,0016020,0016758 Ki=245uM -logKd/Ki=3.61, Ki=245uM P14769 17493636 1360 KLKLSDWFNPFKRPEVVTMTKWKAPVVWEGTYNRAVLDNYYAKQKITVGLTVFAVGRYIEHYLEEFLTSANKHFMVGHPVIFYIMVDDVSRMPLIELGPLRSFKVFKIKPEKRWQDISMMRMKTIGEHIVAHIQHEVDFLFCMDVDQVFQDKFGVETLGESVAQLQAWWYKADPNDFTYERRKESAAYIPFGEGDFYYHAAIFGGTPTQVLNITQECFKGILKDKKNDIEAQWHDESHLNKYFLLNKPTKILSPEYCWDYHIGLPADIKLVKMSWQTK 2vfz B 2.4 BS01 UPF B 1 F1134 A1135 V1136 Y1139 W1195 I1198 S1199 R1202 D1225 V1226 D1227 H1280 A1281 A1282 H1315 D1316 E1317 K1359 F52 A53 V54 Y57 W113 I116 S117 R120 D143 V144 D145 H198 A199 A200 H233 D234 E235 K277 Q1247 H1280 W1314 E1317 W1356 Q165 H198 W232 E235 W274 2.4.1.87 0005975,0016020,0016758 Ki=245uM P14769 17493636 2364 LKLSDWFNPFKRPEVVTMTKWKAPVVWEGTYNRAVLDNYYAKQKITVGLTVFAVGRYIEHYLEEFLTSANKHFMVGHPVIFYIMVDDVSRMPLIELGPLRSFKVFKIKPEKRWQDISMMRMKTIGEHIVAHIQHEVDFLFCMDVDQVFQDKFGVETLGESVAQLQAWWYKADPNDFTYERRKESAAYIPFGEGDFYYHAAIFGGTPTQVLNITQECFKGILKDKKNDIEAQWHDESHLNKYFLLNKPTKILSPEYCWDYHIGLPADIKLVKMSWQTKEYNV