4bj9 A 2.05 BS02 UHB A 1 H1031 G1032 S1033 F1035 I1039 H1048 A1049 I1051 G1058 Y1060 S1068 Y1071 H80 G81 S82 F84 I88 H97 A98 I100 G107 Y109 S117 Y120 2.4.2.-,2.4.2.30 0003950 ic50=45nM -logKd/Ki=7.35, IC50=45nM Q9H2K2 24900770 2165 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 4bj9 B 2.05 BS02 UHB B 1 H1031 G1032 S1033 F1035 F1044 D1045 H1048 A1049 I1051 G1058 Y1060 K1067 S1068 Y1071 E1138 H80 G81 S82 F84 F93 D94 H97 A98 I100 G107 Y109 K116 S117 Y120 E184 2.4.2.-,2.4.2.30 0003950 ic50=45nM Q9H2K2 24900770 2165 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 4tk5 A 2.02 BS02 UHB A 1 H1031 G1032 S1033 F1035 I1039 F1044 D1045 H1048 A1049 G1058 Y1060 S1068 Y1071 H72 G73 S74 F76 I80 F85 D86 H89 A90 G99 Y101 S109 Y112 2.4.2.-,2.4.2.30 0003950 -logKd/Ki=7.49, IC50=32nM Q9H2K2 25286857 1202 PDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRP 4tk5 B 2.02 BS02 UHB B 1 H1031 G1032 S1033 F1035 I1039 D1045 H1048 A1049 G1058 Y1060 S1068 Y1071 H75 G76 S77 F79 I83 D89 H92 A93 G101 Y103 S111 Y114 2.4.2.-,2.4.2.30 0003950 Q9H2K2 25286857 1202 LYFQGDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRP 4tk5 C 2.02 BS02 UHB C 1 H1031 G1032 S1033 I1039 G1043 F1044 D1045 H1048 A1049 Y1060 S1068 Y1071 H79 G80 S81 I87 G91 F92 D93 H96 A97 Y108 S116 Y119 2.4.2.-,2.4.2.30 0003950 Q9H2K2 25286857 1202 NLYFQGSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRP 4tk5 D 2.02 BS01 UHB D 1 H1031 G1032 S1033 F1035 D1045 H1048 A1049 G1058 Y1060 S1068 Y1071 E1138 H70 G71 S72 F74 D84 H87 A88 G97 Y99 S107 Y110 E177 2.4.2.-,2.4.2.30 0003950 Q9H2K2 25286857 1201 DKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRP 5dsy A 2.7 BS01 UHB A 1 H415 G416 S417 N421 G424 I425 R431 Y449 S457 Y460 E545 H95 G96 S97 N101 G104 I105 R111 Y129 S137 Y140 E225 S457 Y460 E545 S137 Y140 E225 2.4.2.-,2.4.2.30 0003950 Q9UGN5 26626480 1001 PESQLDLRVQELIKLICNQSPEHPLDQHYRNLHCALRPLDHESYEFKVISQYLQSTHAPTHSDYTMTLLDLFEVEKDGEKEAFREDLHNRMLLWHGSRMSNWVGILSHGLRIAPPEAPITGYMFGKGIYFADMSSKSANYCFASRLKNTGLLLLSEVALGQCNELLEANPKAEGLLQGKHSTKGLGKMAPSSAHFVTLNGSTVPLGPASDTGILNPDGYTLNYNEYIVYNPNQVRMRYLLKVQFNFLQ 5dsy B 2.7 BS01 UHB B 1 H415 G416 S417 G424 I425 L430 R431 A433 Y449 S457 Y460 H96 G97 S98 G105 I106 L111 R112 A114 Y130 S138 Y141 S457 Y460 E545 S138 Y141 E226 2.4.2.-,2.4.2.30 0003950 Q9UGN5 26626480 1001 PESQLDLRVQELIKLICNLQSPEHPLDQHYRNLHCALRPLDHESYEFKVISQYLQSTHAPTHSDYTMTLLDLFEVEKDGEKEAFREDLHNRMLLWHGSRMSNWVGILSHGLRIAPPEAPITGYMFGKGIYFADMSSKSANYCFASRLKNTGLLLLSEVALGQCNELLEANPKAEGLLQGKHSTKGLGKMAPSSAHFVTLNGSTVPLGPASDTGILNPDGYTLNYNEYIVYNPNQVRMRYLLKVQFNFLQLW 5dsy C 2.7 BS01 UHB C 1 H415 G416 S417 G424 I425 R431 Y449 S457 Y460 E545 H95 G96 S97 G104 I105 R111 Y129 S137 Y140 E225 S457 Y460 E545 S137 Y140 E225 2.4.2.-,2.4.2.30 0003950 Q9UGN5 26626480 1001 PESQLDLRVQELIKLICNQSPEHPLDQHYRNLHCALRPLDHESYEFKVISQYLQSTHAPTHSDYTMTLLDLFEVEKDGEKEAFREDLHNRMLLWHGSRMSNWVGILSHGLRIAPPEAPITGYMFGKGIYFADMSSKSANYCFASRLKNTGLLLLSEVALGQCNELLEANPKAEGLLQGKHSTKGLGKMAPSSAHFVTLNGSTVPLGPASDTGILNPDGYTLNYNEYIVYNPNQVRMRYLLKVQFNFLQ 5dsy D 2.7 BS01 UHB D 1 H415 G416 S417 N421 G424 I425 R431 Y449 S457 Y460 H94 G95 S96 N100 G103 I104 R110 Y128 S136 Y139 S457 Y460 E545 S136 Y139 E224 2.4.2.-,2.4.2.30 0003950 Q9UGN5 26626480 1001 PESQLDLRVQELIKLICNSPEHPLDQHYRNLHCALRPLDHESYEFKVISQYLQSTHAPTHSDYTMTLLDLFEVEKDGEKEAFREDLHNRMLLWHGSRMSNWVGILSHGLRIAPPEAPITGYMFGKGIYFADMSSKSANYCFASRLKNTGLLLLSEVALGQCNELLEANPKAEGLLQGKHSTKGLGKMAPSSAHFVTLNGSTVPLGPASDTGILNPDGYTLNYNEYIVYNPNQVRMRYLLKVQFNFLQ 6hxr A 2.9 BS01 UHB A 1 H152 G153 S154 N158 S161 I162 L167 H168 L171 Y182 A190 Y193 H149 G150 S151 N155 S158 I159 L164 H165 L168 Y176 A184 Y187 2.4.2.- 0003950 Q8N5Y8 301 MGWAAAREAAGRDMLAADLRCSLFASALQSYKRDSVLRPFPASYARGDCKDFEALLADASKLPNLKELLQSSGDNHKRAWDLVSWILSSKVLTIHSAGKAEFEKIQKLTGAPHTPVPAPDFLFEIEYFDPANAKFYETKGERDLIYAFHGSRLENFHSIIHNGLHCHLSLFGEGTYLTSDLSLALIYSPHGHGWQHSLLGPILSCVAVCEVIDHPDPPKYFVVTNNQLLRVKYLLVYSQK 6hxr B 2.9 BS01 UHB B 1 H152 G153 S154 S161 I162 L167 H168 Y182 A190 Y193 H150 G151 S152 S159 I160 L165 H166 Y173 A181 Y184 2.4.2.- 0003950 Q8N5Y8 301 SMGWAAAREAAGRDMLAADLRCSLFASALQSYKRDSVLRPFPASYARGDCKDFEALLADASKLPNLKELLQSSGDNHKRAWDLVSWILSSKVLTIHSAGKAEFEKIQKLTGAPHTPVPAPDFLFEIEYFDPANAKFYETKGERDLIYAFHGSRLENFHSIIHNGLHCHGEGTYLTSDLSLALIYSPHGHGWQHSLLGPILSCVAVCEVIDHPDIPPKYFVVTNNQLLRVKYLLVYSQK 6tx3 B 2.96 BS01 UHB B 1 H415 G416 S417 G424 I425 R431 Y442 Y449 S457 Y460 E545 H94 G95 S96 G103 I104 R110 Y121 Y128 S136 Y139 E224 S457 Y460 E545 S136 Y139 E224 2.4.2.-,2.4.2.30 0003950 Q9UGN5 32028527 1001 PESQLDLRVQELIKLICNSPEHPLDQHYRNLHCALRPLDHESYEFKVISQYLQSTHAPTHSDYTMTLLDLFEVEKDGEKEAFREDLHNRMLLWHGSRMSNWVGILSHGLRIAPPEAPITGYMFGKGIYFADMSSKSANYCFASRLKNTGLLLLSEVALGQCNELLEANPKAEGLLQGKHSTKGLGKMAPSSAHFVTLNGSTVPLGPASDTGILNPDGYTLNYNEYIVYNPNQVRMRYLLKVQFNFLQLW 6vkq A 2.9 BS01 UHB A 1 L769 D770 H862 G863 S864 I872 L877 R878 Y889 Y896 S904 Y907 E988 L106 D107 H191 G192 S193 I201 L206 R207 Y218 Y225 S233 Y236 E317 S904 Y907 E988 S233 Y236 E317 2.4.2.-,2.4.2.30 0003950 P09874 32241924 2001 KLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKAEMLDNLLDIEVAYSLLRGGIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKT 6vkq B 2.9 BS01 UHB B 1 L769 H862 G863 S864 G876 L877 R878 Y889 Y896 S904 Y907 E988 L106 H191 G192 S193 G205 L206 R207 Y218 Y225 S233 Y236 E317 S904 Y907 E988 S233 Y236 E317 2.4.2.-,2.4.2.30 0003950 P09874 32241924 2001 KLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKAEMLDNLLDIEVAYSLLRGGIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKT 6vkq C 2.9 BS01 UHB C 1 H862 G863 S864 G876 L877 R878 Y889 Y896 S904 Y907 E988 H191 G192 S193 G205 L206 R207 Y218 Y225 S233 Y236 E317 S904 Y907 E988 S233 Y236 E317 2.4.2.-,2.4.2.30 0003950 P09874 32241924 2001 KLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKAEMLDNLLDIEVAYSLLRGGIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKT 6vkq D 2.9 BS01 UHB D 1 L769 H862 G863 S864 R878 Y889 Y896 S904 Y907 E988 L106 H191 G192 S193 R207 Y218 Y225 S233 Y236 E317 S904 Y907 E988 S233 Y236 E317 2.4.2.-,2.4.2.30 0003950 P09874 32241924 2001 KLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKAEMLDNLLDIEVAYSLLRGGIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKT 7aab A 2.8 BS01 UHB A 1 D770 H862 G863 S864 N868 G871 I872 G876 L877 R878 Y889 Y896 S904 Y907 D109 H201 G202 S203 N207 G210 I211 G215 L216 R217 Y228 Y235 S243 Y246 S904 Y907 E988 S243 Y246 E327 2.4.2.-,2.4.2.30 0003950 P09874 33511412 1101 KSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKAEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKT 7aab B 2.8 BS01 UHB B 1 D770 H862 G863 S864 N868 G871 I872 L877 R878 Y889 Y896 S904 Y907 D109 H201 G202 S203 N207 G210 I211 L216 R217 Y228 Y235 S243 Y246 S904 Y907 E988 S243 Y246 E327 2.4.2.-,2.4.2.30 0003950 P09874 33511412 1101 KSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKAEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKT 7s6h B 3.1 BS02 UHB B 1 H862 G863 S864 N868 G871 I872 R878 Y896 S904 Y907 H311 G312 S313 N317 G320 I321 R327 Y345 S353 Y356 2.4.2.-,2.4.2.30 0003950 P09874 35793673 1102 AAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGGTKSKLPKPVQDLIKMIFDVESMKKAMYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKAEMLDNLLDIEVAYSLLRGGDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLWLEHHHH 7s6h D 3.1 BS02 UHB D 1 H862 G863 S864 N868 G871 I872 R878 Y896 S904 Y907 H313 G314 S315 N319 G322 I323 R329 Y347 S355 Y358 2.4.2.-,2.4.2.30 0003950 P09874 35793673 1102 AAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQKSKLPKPVQDLIKMIFDVESMKKAMYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKAEMLDNLLDIEVAYSLLRGDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLWLEHHHH 8swz A 3.0 BS01 UHB A 1 H438 G439 S440 N444 G447 I448 G452 L453 L454 Y477 Y488 H115 G116 S117 N121 G124 I125 G129 L130 L131 Y154 Y165 2.4.2.- 0003950 Q9UKK3 37971310 602 SEQLQALLLEEVMNSSTLSQEVSDLVEMIWAEALGHLEHMLGSPNPPSLAKYRALRCKIEHVEQNTEEFLRVRKEVLQNHHSKSPVDVLQIFRVGRVNETTEFLSKLGNVRPLLHGSPVQNIVGILCRGLLLPKVVEDRGVQRTDVGNLGSGIYFSDSLSTSIKYSHPGETDGTRLLLICDVALGKCMDLHEKDFSLTEAPPGYDSVHGVSQTASVTTDFEDDEFVVYKTNQVKMKYIIKFSMPGDQI 8swz B 3.0 BS01 UHB B 1 H438 G439 S440 N444 G447 I448 L453 V469 G470 Y477 S485 Y488 E547 H111 G112 S113 N117 G120 I121 L126 V133 G134 Y141 S149 Y152 E211 2.4.2.- 0003950 Q9UKK3 37971310 602 SEQLQALLLEEVMNSSTLSQEVSDLVEMIWAEALGHLEHMLPPSLAKYRALRCKIEHVEQNTEEFLRVRKEVLQNHHSKSPVDVLQIFRVGRVNETTEFLSKLGNVRPLLHGSPVQNIVGILCRGLLLPKVDVGNLGSGIYFSDSLSTSIKYSHPGETDGTRLLLICDVALGKCMDLHEKDFSLTEAPPGYDSVHGVSQTASVTTDFEDDEFVVYKTNQVKMKYIIKFSMPGDQ 8sx2 A 2.95 BS01 UHB A 1 H438 G439 S440 N444 G447 I448 G452 L454 P456 Y477 Y488 H191 G192 S193 N197 G200 I201 G205 L207 P209 Y222 Y233 2.4.2.- 0003950 Q9UKK3 37971310 601 SEQLQALLLEEVMNSSTLSQEVSDLVEMIWAEALGHLEHMLLKPVNRISLNDVSKAEGILLLVKAALKNGETAEQLQKMMTEFYRLIPHKGTMPKEVNLGLLAKKADLCQLIRDMVNVCENPPSLAKYRALRCKIEHVEQNTEEFLRVRKEVLQNHHSKSPVDVLQIFRVGRVNETTEFLSKLGNVRPLLHGSPVQNIVGILCRGLLLPKVVEVGNLGSGIYFSDSLSTSIKYSHPGETDGTRLLLICDVALGKCMDLHEKDFSLTEAPPGYDSVHGVSQTASVTTDFEDDEFVVYKTNQVKMKYIIKFSMPG 8sx2 B 2.95 BS01 UHB B 1 H438 G439 S440 N444 G447 I448 G452 L453 L454 P456 Y477 S485 Y488 H189 G190 S191 N195 G198 I199 G203 L204 L205 P207 Y217 S225 Y228 2.4.2.- 0003950 Q9UKK3 37971310 601 SEQLQALLLEEVMNSSTLSQEVSDLVEMIWAEALGHLEHMLLKPVNRISLNDVSKAEGILLLVKAALKNGETAEQLQKMMTEFYRLIPHKGTMPKEVNLGLLAKKADLCQLIRDMVNVCPPSLAKYRALRCKIEHVEQNTEEFLRVRKEVLQNHHSKSPVDVLQIFRVGRVNETTEFLSKLGNVRPLLHGSPVQNIVGILCRGLLLPKVGNLGSGIYFSDSLSTSIKYSHPGETDGTRLLLICDVALGKCMDLHEKDFSLTEAPPGYDSVHGVSQTASVTTDFEDDEFVVYKTNQVKMKYIIKFSMPG