1uda A 1.8 BS02 UFG A 1 T126 N179 N199 L200 A216 I217 F218 R231 Y233 R292 D295 Y299 T126 N179 N199 L200 A216 I217 F218 R231 Y233 R292 D295 Y299 S124 A125 T126 Y149 K153 M189 S124 A125 T126 Y149 K153 M189 5.1.3.2 0003978,0005515,0005737,0005829,0005975,0006012,0009242,0016853,0016857,0033499,0042802,0070403 Ki=1.4mM P09147 9174344 341 MRVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFIFSSSATVYGDNPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLRYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIHVMDLADGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNYHFAPRREGDLPAYWADASKADRELNWRVTRTLDEMAQDTWHWQSRHPQGYPD 1udb A 1.65 BS02 UFG A 1 Y149 N179 N199 L200 A216 I217 F218 R231 Y233 R292 D295 Y299 Y149 N179 N199 L200 A216 I217 F218 R231 Y233 R292 D295 Y299 S124 A125 T126 Y149 K153 M189 S124 A125 T126 Y149 K153 M189 5.1.3.2 0003978,0005515,0005737,0005829,0005975,0006012,0009242,0016853,0016857,0033499,0042802,0070403 Ki=1.2mM P09147 9174344 341 MRVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFIFSSSATVYGDNPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLRYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIHVMDLADGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNYHFAPRREGDLPAYWADASKADRELNWRVTRTLDEMAQDTWHWQSRHPQGYPD 2cnb A 2.7 BS01 UFG A 1 L102 S142 Y173 F201 N202 H221 L222 P253 I254 F255 C266 R268 V312 R335 D338 L104 S144 Y169 F197 N198 H217 L218 P238 I239 F240 C251 R253 V297 R320 D323 S142 A143 A144 Y173 K177 S144 A145 A146 Y169 K173 5.1.3.2 0000166,0003978,0005829,0006012,0016853,0020015,0033499 Q8T8E9 16946458 1382 SHMRVLVCGGAGYIGSHFVRALLRDTNHSVVIVDSLVGTHGKSDHVETRENVARKLQQSDGPKPPWADRYAALEVGDVRNEDFLNGVFTRHGPIDAVVHMCAFLAVGESVRDPLKYYDNNVVGILRLLQAMLLHKCDKIIFSSSAAIFGNPTNAEPIDINAKKSPESPYGESKLIAERMIRDCAEAYGIKGICLRYFNACGAHEDGDIGEHYQGSTHLIPIILGRVMSDIAPDDKRMPIFGTDYPTPDGTCVRDYVHVCDLASAHILALDYVEKLGPNDKSKYFSVFNLGTSRGYSVREVIEVARKTTGHPIPVRECGRREGDPAYLVAASDKAREVLGWKPKYDTLEAIMETSWKFQRTHPNGYA 2cnb B 2.7 BS01 UFG B 1 L102 V104 S142 Y173 F201 N202 H221 L222 I225 M252 P253 I254 F255 C266 R268 V312 R335 D338 L104 V106 S144 Y168 F196 N197 H216 L217 I220 M234 P235 I236 F237 C248 R250 V294 R317 D320 S142 A143 A144 Y173 K177 S144 A145 A146 Y168 K172 5.1.3.2 0000166,0003978,0005829,0006012,0016853,0020015,0033499 Q8T8E9 16946458 1382 SHMRVLVCGGAGYIGSHFVRALLRDTNHSVVIVDSLVGTHGKSDHVETRENVARKLQQSDGPKPPWADRYAALEVGDVRNEDFLNGVFTRHGPIDAVVHMCAFLAVGESVRDPLKYYDNNVVGILRLLQAMLLHKCDKIIFSSSAAIFGNPTAEPIDINAKKSPESPYGESKLIAERMIRDCAEAYGIKGICLRYFNACGAHEDGDIGEHYQGSTHLIPIILGRVMSDIADKRMPIFGTDYPTPDGTCVRDYVHVCDLASAHILALDYVEKLGPNDKSKYFSVFNLGTSRGYSVREVIEVARKTTGHPIPVRECGRREGDPAYLVAASDKAREVLGWKPKYDTLEAIMETSWKFQRTHPNGYA 2cnb C 2.7 BS01 UFG C 1 L102 S142 Y173 F201 N202 H221 L222 M252 P253 F255 C266 R268 V312 R335 D338 L104 S144 Y168 F196 N197 H216 L217 M237 P238 F240 C251 R253 V297 R320 D323 S142 A143 A144 Y173 K177 S144 A145 A146 Y168 K172 5.1.3.2 0000166,0003978,0005829,0006012,0016853,0020015,0033499 Q8T8E9 16946458 1382 SHMRVLVCGGAGYIGSHFVRALLRDTNHSVVIVDSLVGTHGKSDHVETRENVARKLQQSDGPKPPWADRYAALEVGDVRNEDFLNGVFTRHGPIDAVVHMCAFLAVGESVRDPLKYYDNNVVGILRLLQAMLLHKCDKIIFSSSAAIFGNPTAEPIDINAKKSPESPYGESKLIAERMIRDCAEAYGIKGICLRYFNACGAHEDGDIGEHYQGSTHLIPIILGRVMSDIAPDTDKRMPIFGTDYPTPDGTCVRDYVHVCDLASAHILALDYVEKLGPNDKSKYFSVFNLGTSRGYSVREVIEVARKTTGHPIPVRECGRREGDPAYLVAASDKAREVLGWKPKYDTLEAIMETSWKFQRTHPNGYA 2cnb D 2.7 BS01 UFG D 1 L102 V104 S142 Y173 F201 N202 H221 L222 I225 M252 I254 F255 C266 R268 V312 R335 D338 L104 V106 S144 Y169 F197 N198 H217 L218 I221 M235 I237 F238 C249 R251 V295 R318 D321 S142 A143 A144 Y173 K177 S144 A145 A146 Y169 K173 5.1.3.2 0000166,0003978,0005829,0006012,0016853,0020015,0033499 Q8T8E9 16946458 1382 SHMRVLVCGGAGYIGSHFVRALLRDTNHSVVIVDSLVGTHGKSDHVETRENVARKLQQSDGPKPPWADRYAALEVGDVRNEDFLNGVFTRHGPIDAVVHMCAFLAVGESVRDPLKYYDNNVVGILRLLQAMLLHKCDKIIFSSSAAIFGNPTNAEPIDINAKKSPESPYGESKLIAERMIRDCAEAYGIKGICLRYFNACGAHEDGDIGEHYQGSTHLIPIILGRVMSDIADKRMPIFGTDYPTPDGTCVRDYVHVCDLASAHILALDYVEKLGPNDKSKYFSVFNLGTSRGYSVREVIEVARKTTGHPIPVRECGRREGDPAYLVAASDKAREVLGWKPKYDTLEAIMETSWKFQRTHPNGYA