1dli A 2.31 BS02 UDX A 1 F142 L143 R144 E145 K204 V215 Y249 N250 N251 S253 G257 C260 L261 M319 K320 R381 D402 F142 L143 R144 E145 K204 V215 Y249 N250 N251 S253 G257 C260 L261 M319 K320 R381 D402 T118 E145 K204 N208 C260 D264 T118 E145 K204 N208 C260 D264 1.1.1.22 0000271,0003979,0006065,0016491,0016616,0051287 P0C0F4 10841783 404 MKIAVAGSGYVGLSLGVLLSLQNEVTIVDILPSKVDKINNGLSPIQDEYIEYYLKSKQLSIKATLDSKAAYKEAELVIIATPTNYNSRINYFDTQHVETVIKEVLSVNSHATLIIKSTIPIGFITEMRQKFQTDRIIFSPEFLRESKALYDNLYPSRIIVSCEENDSPKVKADAEKFALLLKSAAKKNNVPVLIMGASEAEAVKLFANTYLALRVAYFNELDTYAESRKLNSHMIIQGISYDDRIGMHYNNPSFGYGGYCLPKDTKQLLANYNNIPQTLIEAIVSSNNVRKSYIAKQIINVLKEQESPVKVVGVYRLIMKSNSDNFRESAIKDVIDILKSKDIKIIIYEPMLNKLESEDQSVLVNDLENFKKQANIIVTNRYDNELQDVKNKVYSRDIFGRD 3prj A 3.1 BS02 UDX A 1 T131 F162 L163 A164 E165 K220 I231 F265 K267 S269 F272 G273 C276 F277 F338 K339 R442 T131 F162 L163 A164 E165 K220 I231 F265 K267 S269 F272 G273 C276 F277 F338 K339 R435 T131 E165 K220 N224 C276 D280 T131 E165 K220 N224 C276 D280 1.1.1.22 0001702,0003979,0005634,0005654,0005829,0006024,0006065,0015012,0016491,0016616,0030206,0034214,0042802,0048666,0051287,0070062 O60701 21595445 501 MFEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNESRINAWNSPTLPIYEPGLKEVVESCRGKNLFFSTNIDDAIKEADLVFISVNTPTKTYGMGKGRAADLKYIEACARRIVQNSNGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNPEFLAEGTAIKDLKNPDRVLIGGDETPEGQRAVQALCAVYEHWVPREKILTTNTWSSELSKLAANAFLAQRISSINSISALCEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDEGAHLHIYDPKVPREQIVVDLSDQVSRLVTISKDPYEACDGAHAVVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLDGLHNELQTIGFQIETIGKKV 3prj B 3.1 BS02 UDX B 1 T131 F162 L163 A164 E165 K220 I231 F265 K267 S269 F272 C276 F277 F338 K339 R442 T131 F162 L163 A164 E165 K220 I231 F265 K267 S269 F272 C276 F277 F338 K339 R435 T131 E165 K220 N224 C276 D280 T131 E165 K220 N224 C276 D280 1.1.1.22 0001702,0003979,0005634,0005654,0005829,0006024,0006065,0015012,0016491,0016616,0030206,0034214,0042802,0048666,0051287,0070062 O60701 21595445 501 MFEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNESRINAWNSPTLPIYEPGLKEVVESCRGKNLFFSTNIDDAIKEADLVFISVNTPTKTYGMGKGRAADLKYIEACARRIVQNSNGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNPEFLAEGTAIKDLKNPDRVLIGGDETPEGQRAVQALCAVYEHWVPREKILTTNTWSSELSKLAANAFLAQRISSINSISALCEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDEGAHLHIYDPKVPREQIVVDLSDQVSRLVTISKDPYEACDGAHAVVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLDGLHNELQTIGFQIETIGKKV 3prj C 3.1 BS02 UDX C 1 T131 F162 L163 A164 E165 K220 I231 F265 K267 S269 F272 G273 C276 F277 F338 K339 R442 T131 F162 L163 A164 E165 K220 I231 F265 K267 S269 F272 G273 C276 F277 F338 K339 R435 T131 E165 K220 N224 C276 D280 T131 E165 K220 N224 C276 D280 1.1.1.22 0001702,0003979,0005634,0005654,0005829,0006024,0006065,0015012,0016491,0016616,0030206,0034214,0042802,0048666,0051287,0070062 O60701 21595445 501 MFEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNESRINAWNSPTLPIYEPGLKEVVESCRGKNLFFSTNIDDAIKEADLVFISVNTPTKTYGMGKGRAADLKYIEACARRIVQNSNGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNPEFLAEGTAIKDLKNPDRVLIGGDETPEGQRAVQALCAVYEHWVPREKILTTNTWSSELSKLAANAFLAQRISSINSISALCEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDEGAHLHIYDPKVPREQIVVDLSDQVSRLVTISKDPYEACDGAHAVVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLDGLHNELQTIGFQIETIGKKV 3prj D 3.1 BS02 UDX D 1 T131 F162 L163 A164 E165 K220 I231 F265 K267 S269 G273 C276 F277 F338 K339 R442 T131 F162 L163 A164 E165 K220 I231 F265 K267 S269 G273 C276 F277 F338 K339 R435 T131 E165 K220 N224 C276 D280 T131 E165 K220 N224 C276 D280 1.1.1.22 0001702,0003979,0005634,0005654,0005829,0006024,0006065,0015012,0016491,0016616,0030206,0034214,0042802,0048666,0051287,0070062 O60701 21595445 501 MFEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNESRINAWNSPTLPIYEPGLKEVVESCRGKNLFFSTNIDDAIKEADLVFISVNTPTKTYGMGKGRAADLKYIEACARRIVQNSNGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNPEFLAEGTAIKDLKNPDRVLIGGDETPEGQRAVQALCAVYEHWVPREKILTTNTWSSELSKLAANAFLAQRISSINSISALCEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDEGAHLHIYDPKVPREQIVVDLSDQVSRLVTISKDPYEACDGAHAVVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLDGLHNELQTIGFQIETIGKK 3prj E 3.1 BS02 UDX E 1 T131 F162 L163 E165 K220 I231 F265 K267 S269 F272 G273 C276 F277 F338 K339 R442 T131 F162 L163 E165 K220 I231 F265 K267 S269 F272 G273 C276 F277 F338 K339 R435 T131 E165 K220 N224 C276 D280 T131 E165 K220 N224 C276 D280 1.1.1.22 0001702,0003979,0005634,0005654,0005829,0006024,0006065,0015012,0016491,0016616,0030206,0034214,0042802,0048666,0051287,0070062 O60701 21595445 501 MFEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNESRINAWNSPTLPIYEPGLKEVVESCRGKNLFFSTNIDDAIKEADLVFISVNTPTKTYGMGKGRAADLKYIEACARRIVQNSNGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNPEFLAEGTAIKDLKNPDRVLIGGDETPEGQRAVQALCAVYEHWVPREKILTTNTWSSELSKLAANAFLAQRISSINSISALCEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDEGAHLHIYDPKVPREQIVVDLSDQVSRLVTISKDPYEACDGAHAVVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLDGLHNELQTIGFQIETIGKKV 3prj F 3.1 BS02 UDX F 1 T131 F162 L163 A164 E165 K220 I231 F265 K267 S269 F272 G273 C276 F277 F338 K339 R442 T131 F162 L163 A164 E165 K220 I231 F265 K267 S269 F272 G273 C276 F277 F338 K339 R435 T131 E165 K220 N224 C276 D280 T131 E165 K220 N224 C276 D280 1.1.1.22 0001702,0003979,0005634,0005654,0005829,0006024,0006065,0015012,0016491,0016616,0030206,0034214,0042802,0048666,0051287,0070062 O60701 21595445 501 MFEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNESRINAWNSPTLPIYEPGLKEVVESCRGKNLFFSTNIDDAIKEADLVFISVNTPTKTYGMGKGRAADLKYIEACARRIVQNSNGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNPEFLAEGTAIKDLKNPDRVLIGGDETPEGQRAVQALCAVYEHWVPREKILTTNTWSSELSKLAANAFLAQRISSINSISALCEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDEGAHLHIYDPKVPREQIVVDLSDQVSRLVTISKDPYEACDGAHAVVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLDGLHNELQTIGFQIETIGKKV 3ptz A 2.5 BS02 UDX A 1 F162 L163 A164 E165 K220 I231 F265 K267 S269 F272 G273 C276 F277 F338 K339 R442 F162 L163 A164 E165 K220 I231 F265 K267 S269 F272 G273 C276 F277 F338 K339 R435 T131 E165 K220 N224 C276 D280 T131 E165 K220 N224 C276 D280 1.1.1.22 0001702,0003979,0005634,0005654,0005829,0006024,0006065,0015012,0016491,0016616,0030206,0034214,0042802,0048666,0051287,0070062 O60701 21595445 501 MFEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNESRINAWNSPTLPIYEPGLKEVVESCRGKNLFFSTNIDDAIKEADLVFISVNTPTKTYGMGKGRAADLKYIEACARRIVQNSNGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNPEFLAEGTAIKDLKNPDRVLIGGDETPEGQRAVQALCAVYEHWVPREKILTTNTWSSELSKLAANAFLAQRISSINSISALCEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDEGAHLHIYDPKVPREQIVVDLSDQVSRLVTISKDPYEACDGAHAVVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLDGLHNELQTIGFQIETIGKK 3ptz B 2.5 BS02 UDX B 1 F162 L163 A164 E165 K220 I231 F265 K267 S269 F272 G273 C276 F277 F338 K339 R442 F161 L162 A163 E164 K219 I230 F264 K266 S268 F271 G272 C275 F276 F337 K338 R434 T131 E165 K220 N224 C276 D280 T130 E164 K219 N223 C275 D279 1.1.1.22 0001702,0003979,0005634,0005654,0005829,0006024,0006065,0015012,0016491,0016616,0030206,0034214,0042802,0048666,0051287,0070062 O60701 21595445 501 FEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNESRINAWNSPTLPIYEPGLKEVVESCRGKNLFFSTNIDDAIKEADLVFISVNTPTKTYGMGKGRAADLKYIEACARRIVQNSNGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNPEFLAEGTAIKDLKNPDRVLIGGDETPEGQRAVQALCAVYEHWVPREKILTTNTWSSELSKLAANAFLAQRISSINSISALCEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDEGAHLHIYDPKVPREQIVVDLSDQVSRLVTISKDPYEACDGAHAVVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLDGLHNELQTIGFQIETIGKK 3ptz C 2.5 BS02 UDX C 1 F162 L163 A164 E165 K220 I231 F265 K267 S269 F272 G273 C276 F277 F338 K339 R442 F161 L162 A163 E164 K219 I230 F264 K266 S268 F271 G272 C275 F276 F337 K338 R434 T131 E165 K220 N224 C276 D280 T130 E164 K219 N223 C275 D279 1.1.1.22 0001702,0003979,0005634,0005654,0005829,0006024,0006065,0015012,0016491,0016616,0030206,0034214,0042802,0048666,0051287,0070062 O60701 21595445 501 FEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNESRINAWNSPTLPIYEPGLKEVVESCRGKNLFFSTNIDDAIKEADLVFISVNTPTKTYGMGKGRAADLKYIEACARRIVQNSNGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNPEFLAEGTAIKDLKNPDRVLIGGDETPEGQRAVQALCAVYEHWVPREKILTTNTWSSELSKLAANAFLAQRISSINSISALCEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDEGAHLHIYDPKVPREQIVVDLSDQVSRLVTISKDPYEACDGAHAVVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLDGLHNELQTIGFQIETIGKK 3ptz D 2.5 BS02 UDX D 1 F162 L163 A164 K220 I231 F265 K267 S269 F272 G273 C276 F277 F338 K339 R442 F161 L162 A163 K219 I230 F264 K266 S268 F271 G272 C275 F276 F337 K338 R434 T131 E165 K220 N224 C276 D280 T130 E164 K219 N223 C275 D279 1.1.1.22 0001702,0003979,0005634,0005654,0005829,0006024,0006065,0015012,0016491,0016616,0030206,0034214,0042802,0048666,0051287,0070062 O60701 21595445 501 FEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNESRINAWNSPTLPIYEPGLKEVVESCRGKNLFFSTNIDDAIKEADLVFISVNTPTKTYGMGKGRAADLKYIEACARRIVQNSNGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNPEFLAEGTAIKDLKNPDRVLIGGDETPEGQRAVQALCAVYEHWVPREKILTTNTWSSELSKLAANAFLAQRISSINSISALCEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDEGAHLHIYDPKVPREQIVVDLSDQVSRLVTISKDPYEACDGAHAVVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLDGLHNELQTIGFQIETIGKK 3ptz E 2.5 BS02 UDX E 1 F162 L163 A164 E165 K220 I231 F265 K267 S269 F272 G273 C276 F277 F338 K339 R442 F162 L163 A164 E165 K220 I231 F265 K267 S269 F272 G273 C276 F277 F338 K339 R435 T131 E165 K220 N224 C276 D280 T131 E165 K220 N224 C276 D280 1.1.1.22 0001702,0003979,0005634,0005654,0005829,0006024,0006065,0015012,0016491,0016616,0030206,0034214,0042802,0048666,0051287,0070062 O60701 21595445 501 MFEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNESRINAWNSPTLPIYEPGLKEVVESCRGKNLFFSTNIDDAIKEADLVFISVNTPTKTYGMGKGRAADLKYIEACARRIVQNSNGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNPEFLAEGTAIKDLKNPDRVLIGGDETPEGQRAVQALCAVYEHWVPREKILTTNTWSSELSKLAANAFLAQRISSINSISALCEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDEGAHLHIYDPKVPREQIVVDLSDQVSRLVTISKDPYEACDGAHAVVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLDGLHNELQTIGFQIETIGKK 3ptz F 2.5 BS02 UDX F 1 F162 L163 A164 E165 K220 I231 F265 K267 S269 F272 G273 C276 F277 F338 K339 R442 F161 L162 A163 E164 K219 I230 F264 K266 S268 F271 G272 C275 F276 F337 K338 R434 T131 E165 K220 N224 C276 D280 T130 E164 K219 N223 C275 D279 1.1.1.22 0001702,0003979,0005634,0005654,0005829,0006024,0006065,0015012,0016491,0016616,0030206,0034214,0042802,0048666,0051287,0070062 O60701 21595445 501 FEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNESRINAWNSPTLPIYEPGLKEVVESCRGKNLFFSTNIDDAIKEADLVFISVNTPTKTYGMGKGRAADLKYIEACARRIVQNSNGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNPEFLAEGTAIKDLKNPDRVLIGGDETPEGQRAVQALCAVYEHWVPREKILTTNTWSSELSKLAANAFLAQRISSINSISALCEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDEGAHLHIYDPKVPREQIVVDLSDQVSRLVTISKDPYEACDGAHAVVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLDGLHNELQTIGFQIETIGKK 4wnh A 1.95 BS04 UDX A 1 M103 F104 T105 D225 L226 D227 S289 L327 Q330 H382 N384 M10 F11 T12 D132 L133 D134 S196 L234 Q237 H289 N291 2.4.2.62 0016757,0035252 Q3U4G3 402 VPVDYHLLMMFTKAEHNAPLQAKARVALSSLLRLAKFEAHEVLNLHFVSEEASREVAKALLRELLPPAAGFKCKVIFHDVAVLTDKLFPVVEAMQKYFSAGSGTYYSDSIFFLSVAMHQIMPKEIPRIIQLDLDLKYKTNIRELFEEFDNFLPGAVIGIAREMQPVYRHTFWQFRHENPKTRVGDPPPEGLPGFNSGVMLLNLEAMRQSPLYSHLLEPSWVQQLADKYHFRGHLGDQDFFTMIGMEHPELFHVLDCTWNRQLCTWWRDHGYSDVFQAYFRCEGHVKIYHGNCNTPIPE 5ux7 B 2.69 BS01 UDX B 1 R199 R320 K326 F480 L481 Y492 T514 E517 R198 R319 K325 F479 L480 Y491 T513 E516 2.4.1.11 0004373,0005515,0005634,0005737,0005978,0016757,0042587,0042802,2001069 P27472 801 SRDLQNHLLFETATEVANRVGGIYSVLKSKAPITVAQYKDHYHLIGPLNKATYQNEVDILDWKKPEAFSDEMRPVQHALQTMESRGVHFVYGRWLIEGAPKVILFDLDSVRGYSNEWKGDLWSLVGIPSPENDFETNDAILLGYTVAWFLGEVAHLDSQHAIVAHFHEWLAGVALPLCRKRRIDVVTIFTTHATLLGRYLCASGSFDFYNCLESVDVDHEAGRFGIYHRYCIERAAAHSADVFTTVSQITAFEAEHLLKRKPDGILPNGLNVIKFQAFHEFQNLHALKKEKINDFVRGHFHGCFDFDLDNTLYFFIAGRYEYKNKGADMFIEALARLNYRLKVSGSKKTVVAFIVMPAKNNSFTVEALKGQAEVRALENTVHEVTTSIGKRIFDHAIRYPHNGLTTELPTDLGELLKSSDKVMLKRRILALRRPEGQLPPIVTHNMVDDANDLILNKIRQVQLFNSPSDRVKMIFHPEFLNANNPILGLDYDEFVRGCHLGVFPSYYEPWGYTPAECTVMGVPSITTNVSGFGSYMEDLIETNQAKDYGIYIVDRRFKAPDESVEQLVDYMEEFVKKTRRQRINQRNRTERLSDLLDWKRMGLEYVKARQLALRRGYPDQFRELVGEELNDSNMDALA 5ux7 C 2.69 BS01 UDX C 1 R20 G23 R199 G319 R320 K326 F480 L481 Y492 E517 R19 G22 R198 G318 R319 K325 F479 L480 Y491 E516 2.4.1.11 0004373,0005515,0005634,0005737,0005978,0016757,0042587,0042802,2001069 P27472 801 SRDLQNHLLFETATEVANRVGGIYSVLKSKAPITVAQYKDHYHLIGPLNKATYQNEVDILDWKKPEAFSDEMRPVQHALQTMESRGVHFVYGRWLIEGAPKVILFDLDSVRGYSNEWKGDLWSLVGIPSPENDFETNDAILLGYTVAWFLGEVAHLDSQHAIVAHFHEWLAGVALPLCRKRRIDVVTIFTTHATLLGRYLCASGSFDFYNCLESVDVDHEAGRFGIYHRYCIERAAAHSADVFTTVSQITAFEAEHLLKRKPDGILPNGLNVIKFQAFHEFQNLHALKKEKINDFVRGHFHGCFDFDLDNTLYFFIAGRYEYKNKGADMFIEALARLNYRLKVSGSKKTVVAFIVMPAKNNSFTVEALKGQAEVRALENTVHEVTTSIGKRIFDHAIRYPHNGLTTELPTDLGELLKSSDKVMLKRRILALRRPEGQLPPIVTHNMVDDANDLILNKIRQVQLFNSPSDRVKMIFHPEFLNANNPILGLDYDEFVRGCHLGVFPSYYEPWGYTPAECTVMGVPSITTNVSGFGSYMEDLIETNQAKDYGIYIVDRRFKAPDESVEQLVDYMEEFVKKTRRQRINQRNRTERLSDLLDWKRMGLEYVKARQLALRRGYPDQFRELVGEELNDSNMDALA 5vr8 A 1.999 BS01 UDX A 1 G13 Y14 V15 D36 V37 R41 V89 N90 T91 Y108 S130 T131 R346 G13 Y14 V15 D36 V37 R41 V89 N90 T91 Y108 S130 T131 R346 T131 E165 K220 N224 C276 D280 T131 E165 K220 N224 C276 D280 1.1.1.22 0001702,0003979,0005634,0005654,0005829,0006024,0006065,0015012,0016491,0016616,0030206,0034214,0042802,0048666,0051287,0070062 -logKd/Ki=6.87, Kd=0.135uM O60701 30420606 501 MFEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNESRINAWNSPTLPIYEPGLKEVVESCRGKNLFFSTNIDDAIKEADLVFISVNTPTKTYGMGKGRAADLKYIEACARRIVQNSNGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNPEFLAEGTAIKDLKNPDRVLIGGDETPEGQRAVQALCAVYEHWVPREKILTTNTWSSELSKLAANAFLAQRISSINSISALCEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDEGAHLHIYDPKVPREQIVVDLSHDDQVSRLVTISKDPYEACDGAHAVVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLDGLHNELQTIGFQIETIGKK 5vr8 A 1.999 BS02 UDX A 2 F162 L163 A164 E165 K220 I231 F265 K267 S269 F272 G273 C276 F277 F338 K339 R442 F162 L163 A164 E165 K220 I231 F265 K267 S269 F272 G273 C276 F277 F338 K339 R437 T131 E165 K220 N224 C276 D280 T131 E165 K220 N224 C276 D280 1.1.1.22 0001702,0003979,0005634,0005654,0005829,0006024,0006065,0015012,0016491,0016616,0030206,0034214,0042802,0048666,0051287,0070062 -logKd/Ki=6.87, Kd=0.135uM O60701 30420606 502 MFEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNESRINAWNSPTLPIYEPGLKEVVESCRGKNLFFSTNIDDAIKEADLVFISVNTPTKTYGMGKGRAADLKYIEACARRIVQNSNGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNPEFLAEGTAIKDLKNPDRVLIGGDETPEGQRAVQALCAVYEHWVPREKILTTNTWSSELSKLAANAFLAQRISSINSISALCEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDEGAHLHIYDPKVPREQIVVDLSHDDQVSRLVTISKDPYEACDGAHAVVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLDGLHNELQTIGFQIETIGKK 5vr8 B 1.999 BS01 UDX B 1 G13 Y14 V15 D36 V37 R41 V89 N90 T91 Y108 S130 T131 K279 R346 G14 Y15 V16 D37 V38 R42 V90 N91 T92 Y109 S131 T132 K280 R347 T131 E165 K220 N224 C276 D280 T132 E166 K221 N225 C277 D281 1.1.1.22 0001702,0003979,0005634,0005654,0005829,0006024,0006065,0015012,0016491,0016616,0030206,0034214,0042802,0048666,0051287,0070062 O60701 30420606 501 HMFEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNESRINAWNSPTLPIYEPGLKEVVESCRGKNLFFSTNIDDAIKEADLVFISVNTPTKTYGMGKGRAADLKYIEACARRIVQNSNGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNPEFLAEGTAIKDLKNPDRVLIGGDETPEGQRAVQALCAVYEHWVPREKILTTNTWSSELSKLAANAFLAQRISSINSISALCEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDEGAHLHIYDPKVPREQIVVDLSDQVSRLVTISKDPYEACDGAHAVVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLDGLHNELQTIGFQIETIGKK 5vr8 B 1.999 BS02 UDX B 2 F162 L163 A164 E165 K220 I231 F265 K267 S269 F272 G273 C276 F277 F338 K339 R442 F163 L164 A165 E166 K221 I232 F266 K268 S270 F273 G274 C277 F278 F339 K340 R436 T131 E165 K220 N224 C276 D280 T132 E166 K221 N225 C277 D281 1.1.1.22 0001702,0003979,0005634,0005654,0005829,0006024,0006065,0015012,0016491,0016616,0030206,0034214,0042802,0048666,0051287,0070062 O60701 30420606 502 HMFEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNESRINAWNSPTLPIYEPGLKEVVESCRGKNLFFSTNIDDAIKEADLVFISVNTPTKTYGMGKGRAADLKYIEACARRIVQNSNGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNPEFLAEGTAIKDLKNPDRVLIGGDETPEGQRAVQALCAVYEHWVPREKILTTNTWSSELSKLAANAFLAQRISSINSISALCEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDEGAHLHIYDPKVPREQIVVDLSDQVSRLVTISKDPYEACDGAHAVVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLDGLHNELQTIGFQIETIGKK 5vr8 C 1.999 BS02 UDX C 1 F162 L163 A164 K220 I231 F265 K267 S269 F272 G273 C276 F277 F338 K339 R442 F163 L164 A165 K221 I232 F266 K268 S270 F273 G274 C277 F278 F339 K340 R439 T131 E165 K220 N224 C276 D280 T132 E166 K221 N225 C277 D281 1.1.1.22 0001702,0003979,0005634,0005654,0005829,0006024,0006065,0015012,0016491,0016616,0030206,0034214,0042802,0048666,0051287,0070062 O60701 30420606 501 HMFEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNESRINAWNSPTLPIYEPGLKEVVESCRGKNLFFSTNIDDAIKEADLVFISVNTPTKTYGMGKGRAADLKYIEACARRIVQNSNGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNPEFLAEGTAIKDLKNPDRVLIGGDETPEGQRAVQALCAVYEHWVPREKILTTNTWSSELSKLAANAFLAQRISSINSISALCEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDEGAHLHIYDPKVPREQIVVDLSHEDDQVSRLVTISKDPYEACDGAHAVVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLDGLHNELQTIGFQIETIGKK 5vr8 D 1.999 BS01 UDX D 1 G13 Y14 V15 D36 V37 R41 V89 N90 T91 Y108 S130 T131 K279 R346 G12 Y13 V14 D35 V36 R40 V88 N89 T90 Y107 S129 T130 K278 R345 T131 E165 K220 N224 C276 D280 T130 E164 K219 N223 C275 D279 1.1.1.22 0001702,0003979,0005634,0005654,0005829,0006024,0006065,0015012,0016491,0016616,0030206,0034214,0042802,0048666,0051287,0070062 O60701 30420606 501 FEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNESRINAWNSPTLPIYEPGLKEVVESCRGKNLFFSTNIDDAIKEADLVFISVNTPTKTYGMGKGRAADLKYIEACARRIVQNSNGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNPEFLAEGTAIKDLKNPDRVLIGGDETPEGQRAVQALCAVYEHWVPREKILTTNTWSSELSKLAANAFLAQRISSINSISALCEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDEGAHLHIYDPKVPREQIVVDLSDQVSRLVTISKDPYEACDGAHAVVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLDGLHNELQTIGFQIETIGKK 5vr8 D 1.999 BS02 UDX D 2 F162 L163 A164 K220 L227 I231 F265 K267 S269 F272 G273 C276 F277 F338 K339 R442 F161 L162 A163 K219 L226 I230 F264 K266 S268 F271 G272 C275 F276 F337 K338 R434 T131 E165 K220 N224 C276 D280 T130 E164 K219 N223 C275 D279 1.1.1.22 0001702,0003979,0005634,0005654,0005829,0006024,0006065,0015012,0016491,0016616,0030206,0034214,0042802,0048666,0051287,0070062 O60701 30420606 502 FEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNESRINAWNSPTLPIYEPGLKEVVESCRGKNLFFSTNIDDAIKEADLVFISVNTPTKTYGMGKGRAADLKYIEACARRIVQNSNGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNPEFLAEGTAIKDLKNPDRVLIGGDETPEGQRAVQALCAVYEHWVPREKILTTNTWSSELSKLAANAFLAQRISSINSISALCEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDEGAHLHIYDPKVPREQIVVDLSDQVSRLVTISKDPYEACDGAHAVVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLDGLHNELQTIGFQIETIGKK 5vr8 E 1.999 BS01 UDX E 1 G13 Y14 V15 D36 V37 R41 V89 N90 T91 Y108 S130 T131 K279 R346 G12 Y13 V14 D35 V36 R40 V88 N89 T90 Y107 S129 T130 K278 R345 T131 E165 K220 N224 C276 D280 T130 E164 K219 N223 C275 D279 1.1.1.22 0001702,0003979,0005634,0005654,0005829,0006024,0006065,0015012,0016491,0016616,0030206,0034214,0042802,0048666,0051287,0070062 O60701 30420606 501 FEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNESRINAWNSPTLPIYEPGLKEVVESCRGKNLFFSTNIDDAIKEADLVFISVNTPTKTYGMGKGRAADLKYIEACARRIVQNSNGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNPEFLAEGTAIKDLKNPDRVLIGGDETPEGQRAVQALCAVYEHWVPREKILTTNTWSSELSKLAANAFLAQRISSINSISALCEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDEGAHLHIYDPKVPREQIVVDLSDQVSRLVTISKDPYEACDGAHAVVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLDGLHNELQTIGFQIETIGKK 5vr8 E 1.999 BS02 UDX E 2 F162 L163 A164 E165 K220 I231 F265 K267 S269 F272 G273 C276 F277 F338 K339 R442 F161 L162 A163 E164 K219 I230 F264 K266 S268 F271 G272 C275 F276 F337 K338 R434 T131 E165 K220 N224 C276 D280 T130 E164 K219 N223 C275 D279 1.1.1.22 0001702,0003979,0005634,0005654,0005829,0006024,0006065,0015012,0016491,0016616,0030206,0034214,0042802,0048666,0051287,0070062 O60701 30420606 502 FEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNESRINAWNSPTLPIYEPGLKEVVESCRGKNLFFSTNIDDAIKEADLVFISVNTPTKTYGMGKGRAADLKYIEACARRIVQNSNGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNPEFLAEGTAIKDLKNPDRVLIGGDETPEGQRAVQALCAVYEHWVPREKILTTNTWSSELSKLAANAFLAQRISSINSISALCEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDEGAHLHIYDPKVPREQIVVDLSDQVSRLVTISKDPYEACDGAHAVVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLDGLHNELQTIGFQIETIGKK 5vr8 F 1.999 BS02 UDX F 1 F162 L163 A164 E165 K220 I231 F265 K267 S269 F272 G273 C276 F277 F338 K339 R442 F162 L163 A164 E165 K220 I231 F265 K267 S269 F272 G273 C276 F277 F338 K339 R435 T131 E165 K220 N224 C276 D280 T131 E165 K220 N224 C276 D280 1.1.1.22 0001702,0003979,0005634,0005654,0005829,0006024,0006065,0015012,0016491,0016616,0030206,0034214,0042802,0048666,0051287,0070062 O60701 30420606 501 MFEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNESRINAWNSPTLPIYEPGLKEVVESCRGKNLFFSTNIDDAIKEADLVFISVNTPTKTYGMGKGRAADLKYIEACARRIVQNSNGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNPEFLAEGTAIKDLKNPDRVLIGGDETPEGQRAVQALCAVYEHWVPREKILTTNTWSSELSKLAANAFLAQRISSINSISALCEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDEGAHLHIYDPKVPREQIVVDLSDQVSRLVTISKDPYEACDGAHAVVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLDGLHNELQTIGFQIETIGKK 6c58 A 2.198 BS01 UDX A 1 G13 Y14 V15 D36 V37 R41 V89 N90 T91 S130 T131 R346 G13 Y14 V15 D36 V37 R41 V89 N90 T91 S130 T131 R346 T131 E165 K220 N224 C276 D280 T131 E165 K220 N224 C276 D280 1.1.1.22 0001702,0003979,0005634,0005654,0005829,0006024,0006065,0015012,0016491,0016616,0030206,0034214,0042802,0048666,0051287,0070062 O60701 501 MFEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNESRINAWNSPTLPIYEPGLKEVVESCRGKNLFFSTNIDDAIKEADLVFISVNTPTKTYGMGKGRAADLKYIEACARRIVQNSNGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNPEFLAEGTAIKDLKNPDRVLIGGDETPEGQRAVQALCAVYEHWVPREKILTTNTWSSELSKLAANLFLAQRISSINSISALCEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDEGAHLHIYDPKVPREQIVVDLSHPDDQVSRLVTISKDPYEACDGAHAVVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLDGLHNELQTIGFQIETIGKK 6c58 A 2.198 BS02 UDX A 2 T131 F162 L163 A164 E165 K220 I231 F265 K267 S269 F272 G273 C276 F277 F338 K339 R442 T131 F162 L163 A164 E165 K220 I231 F265 K267 S269 F272 G273 C276 F277 F338 K339 R438 T131 E165 K220 N224 C276 D280 T131 E165 K220 N224 C276 D280 1.1.1.22 0001702,0003979,0005634,0005654,0005829,0006024,0006065,0015012,0016491,0016616,0030206,0034214,0042802,0048666,0051287,0070062 O60701 502 MFEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNESRINAWNSPTLPIYEPGLKEVVESCRGKNLFFSTNIDDAIKEADLVFISVNTPTKTYGMGKGRAADLKYIEACARRIVQNSNGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNPEFLAEGTAIKDLKNPDRVLIGGDETPEGQRAVQALCAVYEHWVPREKILTTNTWSSELSKLAANLFLAQRISSINSISALCEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDEGAHLHIYDPKVPREQIVVDLSHPDDQVSRLVTISKDPYEACDGAHAVVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLDGLHNELQTIGFQIETIGKK 6c58 B 2.198 BS01 UDX B 1 G13 Y14 V15 D36 V37 R41 V89 N90 T91 S130 T131 R346 G12 Y13 V14 D35 V36 R40 V88 N89 T90 S129 T130 R345 T131 E165 K220 N224 C276 D280 T130 E164 K219 N223 C275 D279 1.1.1.22 0001702,0003979,0005634,0005654,0005829,0006024,0006065,0015012,0016491,0016616,0030206,0034214,0042802,0048666,0051287,0070062 O60701 501 FEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNESRINAWNSPTLPIYEPGLKEVVESCRGKNLFFSTNIDDAIKEADLVFISVNTPTKTYGMGKGRAADLKYIEACARRIVQNSNGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNPEFLAEGTAIKDLKNPDRVLIGGDETPEGQRAVQALCAVYEHWVPREKILTTNTWSSELSKLAANLFLAQRISSINSISALCEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDEGAHLHIYDPKVPREQIVVDLSHPDQVSRLVTISKDPYEACDGAHAVVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLDGLHNELQTIGFQIETIGKK 6c58 B 2.198 BS02 UDX B 2 T131 F162 L163 A164 E165 K220 I231 F265 K267 S269 F272 G273 C276 F277 F338 K339 R442 T130 F161 L162 A163 E164 K219 I230 F264 K266 S268 F271 G272 C275 F276 F337 K338 R436 T131 E165 K220 N224 C276 D280 T130 E164 K219 N223 C275 D279 1.1.1.22 0001702,0003979,0005634,0005654,0005829,0006024,0006065,0015012,0016491,0016616,0030206,0034214,0042802,0048666,0051287,0070062 O60701 502 FEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNESRINAWNSPTLPIYEPGLKEVVESCRGKNLFFSTNIDDAIKEADLVFISVNTPTKTYGMGKGRAADLKYIEACARRIVQNSNGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNPEFLAEGTAIKDLKNPDRVLIGGDETPEGQRAVQALCAVYEHWVPREKILTTNTWSSELSKLAANLFLAQRISSINSISALCEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDEGAHLHIYDPKVPREQIVVDLSHPDQVSRLVTISKDPYEACDGAHAVVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLDGLHNELQTIGFQIETIGKK 6c58 C 2.198 BS01 UDX C 1 G13 Y14 V15 D36 V37 R41 V89 N90 T91 S130 T131 K279 R346 G12 Y13 V14 D35 V36 R40 V88 N89 T90 S129 T130 K278 R345 T131 E165 K220 N224 C276 D280 T130 E164 K219 N223 C275 D279 1.1.1.22 0001702,0003979,0005634,0005654,0005829,0006024,0006065,0015012,0016491,0016616,0030206,0034214,0042802,0048666,0051287,0070062 O60701 500 FEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNESRINAWNSPTLPIYEPGLKEVVESCRGKNLFFSTNIDDAIKEADLVFISVNTPTKTYGMGKGRAADLKYIEACARRIVQNSNGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNPEFLAEGTAIKDLKNPDRVLIGGDETPEGQRAVQALCAVYEHWVPREKILTTNTWSSELSKLAANLFLAQRISSINSISALCEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDEGAHLHIYDPKVPREQIVVDLSHPEDDQVSRLVTISKDPYEACDGAHAVVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLDGLHNELQTIGFQIETIGKK 6c58 C 2.198 BS02 UDX C 2 F162 L163 A164 E165 K220 I231 F265 K267 S269 F272 G273 C276 F277 F338 K339 R442 F161 L162 A163 E164 K219 I230 F264 K266 S268 F271 G272 C275 F276 F337 K338 R438 T131 E165 K220 N224 C276 D280 T130 E164 K219 N223 C275 D279 1.1.1.22 0001702,0003979,0005634,0005654,0005829,0006024,0006065,0015012,0016491,0016616,0030206,0034214,0042802,0048666,0051287,0070062 O60701 501 FEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNESRINAWNSPTLPIYEPGLKEVVESCRGKNLFFSTNIDDAIKEADLVFISVNTPTKTYGMGKGRAADLKYIEACARRIVQNSNGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNPEFLAEGTAIKDLKNPDRVLIGGDETPEGQRAVQALCAVYEHWVPREKILTTNTWSSELSKLAANLFLAQRISSINSISALCEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDEGAHLHIYDPKVPREQIVVDLSHPEDDQVSRLVTISKDPYEACDGAHAVVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLDGLHNELQTIGFQIETIGKK 6c58 D 2.198 BS01 UDX D 1 T131 F162 L163 A164 E165 K220 I231 F265 K267 S269 F272 G273 C276 F277 F338 K339 R442 T116 F147 L148 A149 E150 K205 I216 F250 K252 S254 F257 G258 C261 F262 F323 K324 R426 T131 E165 K220 N224 C276 D280 T116 E150 K205 N209 C261 D265 1.1.1.22 0001702,0003979,0005634,0005654,0005829,0006024,0006065,0015012,0016491,0016616,0030206,0034214,0042802,0048666,0051287,0070062 O60701 501 FEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNESRINAWNSPTLPIYEPGLKEVVESCRGKNLFFSTNIDDAIKEADLVFISVNDLKYIEACARRIVQNSNGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNPEFLAEGTAIKDLKNPDRVLIGGDETPEGQRAVQALCAVYEHWVPREKILTTNTWSSELSKLAANLFLAQRISSINSISALCEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDEGAHLHIYDPKVPREQIVVDLSHPVSEDDQVSRLVTISKDPYEACDGAHAVVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLDGLHNELQTIGFQIETIGKK 6c58 E 2.198 BS01 UDX E 1 T131 F162 L163 A164 E165 K220 I231 F265 K267 S269 F272 G273 C276 F277 F338 K339 R442 T118 F149 L150 A151 E152 K207 I218 F252 K254 S256 F259 G260 C263 F264 F325 K326 R424 T131 E165 K220 N224 C276 D280 T118 E152 K207 N211 C263 D267 1.1.1.22 0001702,0003979,0005634,0005654,0005829,0006024,0006065,0015012,0016491,0016616,0030206,0034214,0042802,0048666,0051287,0070062 O60701 501 MFEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNESRINAWNSPTLPIYEPGLKEVVESCRGKNLFFSTNIDDAIKEADLVFISVNADLKYIEACARRIVQNSNGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNPEFLAEGTAIKDLKNPDRVLIGGDETPEGQRAVQALCAVYEHWVPREKILTTNTWSSELSKLAANLFLAQRISSINSISALCEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDEGAHLHIYDPKVPREQIVVDLSHPDQVSRLVTISKDPYEACDGAHAVVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLDGLHNELQTIGFQIETIGKK 6c58 F 2.198 BS01 UDX F 1 G13 Y14 V15 D36 V37 R41 V89 N90 T91 Y108 S130 T131 R346 G12 Y13 V14 D35 V36 R40 V88 N89 T90 Y107 S129 T130 R345 T131 E165 K220 N224 C276 D280 T130 E164 K219 N223 C275 D279 1.1.1.22 0001702,0003979,0005634,0005654,0005829,0006024,0006065,0015012,0016491,0016616,0030206,0034214,0042802,0048666,0051287,0070062 O60701 500 FEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNESRINAWNSPTLPIYEPGLKEVVESCRGKNLFFSTNIDDAIKEADLVFISVNTPTKTYGMGKGRAADLKYIEACARRIVQNSNGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNPEFLAEGTAIKDLKNPDRVLIGGDETPEGQRAVQALCAVYEHWVPREKILTTNTWSSELSKLAANLFLAQRISSINSISALCEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDEGAHLHIYDPKVPREQIVVDLSHPDQVSRLVTISKDPYEACDGAHAVVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLDGLHNELQTIGFQIETIGKK 6c58 F 2.198 BS02 UDX F 2 T131 F162 L163 A164 E165 K220 I231 F265 K267 S269 F272 G273 C276 F277 F338 K339 R442 T130 F161 L162 A163 E164 K219 I230 F264 K266 S268 F271 G272 C275 F276 F337 K338 R436 T131 E165 K220 N224 C276 D280 T130 E164 K219 N223 C275 D279 1.1.1.22 0001702,0003979,0005634,0005654,0005829,0006024,0006065,0015012,0016491,0016616,0030206,0034214,0042802,0048666,0051287,0070062 O60701 501 FEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNESRINAWNSPTLPIYEPGLKEVVESCRGKNLFFSTNIDDAIKEADLVFISVNTPTKTYGMGKGRAADLKYIEACARRIVQNSNGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNPEFLAEGTAIKDLKNPDRVLIGGDETPEGQRAVQALCAVYEHWVPREKILTTNTWSSELSKLAANLFLAQRISSINSISALCEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDEGAHLHIYDPKVPREQIVVDLSHPDQVSRLVTISKDPYEACDGAHAVVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLDGLHNELQTIGFQIETIGKK 6ej7 A 2.0 BS02 UDX A 1 V333 V334 H335 T390 W392 D494 W495 S575 R598 K599 V82 V83 H84 T139 W141 D243 W244 S324 R347 K348 2.4.2.26 0016020,0016757,0030158,0030166 Q86Y38 29681470 1002 DQPPKCDISGKEAISALSRAKSKHCRQEIGETYCRHKLGLLMPEKVTRFCPLEGKANKNVQWDEDSVEYMPANPVRIAFVLVVHGRASRQLQRMFKAIYHKDHFYYIHVDKRSNYLHRQVLQVSRQYSNVRVTPWRMATIWGGASLLSTYLQSMRDLLEMTDWPWDFFINLSAADYPIRTNDQLVAFLSRYRDMNFLKSHGRDNARFIRKQGLDRLFLECDAHMWRLGDRRIPEGIAVDGGSDWFLLNRRFVEYVTFSTDDLVTKMKQFYSYTLLPAESFFHTVLENSPHCDTMVDNNLRITNWNRKLGCKCQYKHIVDWCGCSPNDFKPQDFHRFQQTARPTFFARKFEAVVNQEIIGQLDYYLYGNYPAGTPGLRSYWENVYDEPDGIHSLSDVTLTLYHSFARLGLRRAETSLHTDGENSCRYYPMGHPASVHLYFLADRFQGFLIKHHATNLAVSKLETLETWVMPKKVFKIASPDFGRLQFSEVGTDWDAKERLFRNFGGLLGPMDEPVGMQKWGKGPNVTVTVIWVDPVNVIAATYDILIESTAEFTHYKPPLNLPLRPGVWTVKILHHWVPVAETKFLVAPLTFSNRQPIKPEEALKLHNGPLRNAYMEQSFQSLNPVLSLPINPAQVEQARRNAASTGTALEGWLDSLVGGMWTAMDICATGPTACPVMQTCSQTAWSSFSPDPKSELGAVKPDGRLR 6kvj A 2.499 BS01 UDX A 1 H26 T147 S284 W339 V340 Q342 H357 G359 W360 N361 S362 E365 H14 T135 S272 W327 V328 Q330 H345 G347 W348 N349 S350 E353 2.4.1.- 0008194,0016740,0035251 Q6VAB4 33404544 801 RRRIILFPVPFQGHINPILQLANVLYSKGFSITIFHTNFNKPKTSNYPHFTFRFILDNDPQDERISNLPTHGPLAGMRIPIINEHGADELRRELELLMLASEEDEEVSCLITDALWYFAQSVADSLNLRRLVLMTSSLFNFHAHVSLPQFDELGYLDPDDKTRLEEQASGFPMLKVKDIKSAYSNWQILKEILGKMIKQTKASSGVIWNSFKELEESELETVIREIPAPSFLIPLPKHLTASSSSLLDHDRTVFQWLDQQPPSSVLYVSFGSTSEVDEKDFLEIARGLVDSKQSFLWVVRPGFVKGSTWVEPLPDGFLGERGRIVKWVPQQEVLAHGAIGAFWTHSGWNSTLESVCEGVPMIFSDFGLDQPLNARYMSDVLKVGVYLENGWERGEIANAIRRVMVDEEGEYIRQNARVLKQKADVSLMKGGSSYESLESLVSYISSLT 6om8 A 2.449 BS01 UDX A 1 G18 Y19 V20 D41 M42 K46 V94 N95 T96 Y113 S135 T136 K286 R353 G11 Y12 V13 D34 M35 K39 V87 N88 T89 Y106 S128 T129 K279 R346 T136 E172 K227 N231 C283 D287 T129 E165 K220 N224 C276 D280 1.1.1.22 0002009,0003979,0005634,0005737,0006024,0006065,0009792,0016491,0016616,0018991,0022414,0040025,0042802,0051287 -logKd/Ki=5.16, Ki=6.9uM Q19905 31616809 500 KVSKVVCVGAGYVGGPTCAMIAHKCPHITVTVVDMNTAKIAEWNSDKLPIYEPGLDEIVFAARGRNLFFSSDIPKAIAEADLIFISVNTPTKMYGRGKGMAPDLKYVESVSRTIAQYAGGPKIVVEKSTVPVKAAESIGCILREAQKNNENLKFQVLSNPEFLAEGTAMKDLANPDRVLIGGESSPEGLQAVAELVRIYENWVPRNRIITTNTWSSELSKLVANAFLAQRISSINSISAVCEATGAEISEVAHAVGYDTRIGSKFLQASVGFGGSCFQKDVLSLVYLCESLNLPQVADYWQGVININNWQRRRFADKIIAELFNTVTDKKIAIFGFAFKKNTGDTRESSAIHVIKHLMEEHAKLSVYDPKVQKSQMLNDLASVTSAQDVERLITVESDPYAAARGAHAIVVLTEWDEFVELNYSQIHNDMQHPAAIFDGRLILDQKALREIGFRTFAIGTSPD 6om8 A 2.449 BS02 UDX A 2 F169 L170 A171 E172 K227 I238 F272 Q274 S276 F279 G280 C283 F284 F345 K346 R447 F162 L163 A164 E165 K220 I231 F265 Q267 S269 F272 G273 C276 F277 F338 K339 R440 T136 E172 K227 N231 C283 D287 T129 E165 K220 N224 C276 D280 1.1.1.22 0002009,0003979,0005634,0005737,0006024,0006065,0009792,0016491,0016616,0018991,0022414,0040025,0042802,0051287 -logKd/Ki=5.16, Ki=6.9uM Q19905 31616809 501 KVSKVVCVGAGYVGGPTCAMIAHKCPHITVTVVDMNTAKIAEWNSDKLPIYEPGLDEIVFAARGRNLFFSSDIPKAIAEADLIFISVNTPTKMYGRGKGMAPDLKYVESVSRTIAQYAGGPKIVVEKSTVPVKAAESIGCILREAQKNNENLKFQVLSNPEFLAEGTAMKDLANPDRVLIGGESSPEGLQAVAELVRIYENWVPRNRIITTNTWSSELSKLVANAFLAQRISSINSISAVCEATGAEISEVAHAVGYDTRIGSKFLQASVGFGGSCFQKDVLSLVYLCESLNLPQVADYWQGVININNWQRRRFADKIIAELFNTVTDKKIAIFGFAFKKNTGDTRESSAIHVIKHLMEEHAKLSVYDPKVQKSQMLNDLASVTSAQDVERLITVESDPYAAARGAHAIVVLTEWDEFVELNYSQIHNDMQHPAAIFDGRLILDQKALREIGFRTFAIGTSPD 6om8 B 2.449 BS01 UDX B 1 G18 Y19 V20 D41 M42 K46 V94 N95 T96 Y113 S135 T136 R353 G11 Y12 V13 D34 M35 K39 V87 N88 T89 Y106 S128 T129 R346 T136 E172 K227 N231 C283 D287 T129 E165 K220 N224 C276 D280 1.1.1.22 0002009,0003979,0005634,0005737,0006024,0006065,0009792,0016491,0016616,0018991,0022414,0040025,0042802,0051287 Q19905 31616809 500 KVSKVVCVGAGYVGGPTCAMIAHKCPHITVTVVDMNTAKIAEWNSDKLPIYEPGLDEIVFAARGRNLFFSSDIPKAIAEADLIFISVNTPTKMYGRGKGMAPDLKYVESVSRTIAQYAGGPKIVVEKSTVPVKAAESIGCILREAQKNNENLKFQVLSNPEFLAEGTAMKDLANPDRVLIGGESSPEGLQAVAELVRIYENWVPRNRIITTNTWSSELSKLVANAFLAQRISSINSISAVCEATGAEISEVAHAVGYDTRIGSKFLQASVGFGGSCFQKDVLSLVYLCESLNLPQVADYWQGVININNWQRRRFADKIIAELFNTVTDKKIAIFGFAFKKNTGDTRESSAIHVIKHLMEEHAKLSVYDPKVQKSQMLNDLASVTSAQDVERLITVESDPYAAARGAHAIVVLTEWDEFVELNYSQIHNDMQHPAAIFDGRLILDQKALREIGFRTFAIGTSPD 6om8 B 2.449 BS02 UDX B 2 F169 L170 A171 E172 K227 I238 F272 Q274 S276 F279 G280 C283 F284 F345 K346 R447 F162 L163 A164 E165 K220 I231 F265 Q267 S269 F272 G273 C276 F277 F338 K339 R440 T136 E172 K227 N231 C283 D287 T129 E165 K220 N224 C276 D280 1.1.1.22 0002009,0003979,0005634,0005737,0006024,0006065,0009792,0016491,0016616,0018991,0022414,0040025,0042802,0051287 Q19905 31616809 501 KVSKVVCVGAGYVGGPTCAMIAHKCPHITVTVVDMNTAKIAEWNSDKLPIYEPGLDEIVFAARGRNLFFSSDIPKAIAEADLIFISVNTPTKMYGRGKGMAPDLKYVESVSRTIAQYAGGPKIVVEKSTVPVKAAESIGCILREAQKNNENLKFQVLSNPEFLAEGTAMKDLANPDRVLIGGESSPEGLQAVAELVRIYENWVPRNRIITTNTWSSELSKLVANAFLAQRISSINSISAVCEATGAEISEVAHAVGYDTRIGSKFLQASVGFGGSCFQKDVLSLVYLCESLNLPQVADYWQGVININNWQRRRFADKIIAELFNTVTDKKIAIFGFAFKKNTGDTRESSAIHVIKHLMEEHAKLSVYDPKVQKSQMLNDLASVTSAQDVERLITVESDPYAAARGAHAIVVLTEWDEFVELNYSQIHNDMQHPAAIFDGRLILDQKALREIGFRTFAIGTSPD 6om8 C 2.449 BS01 UDX C 1 G18 Y19 V20 D41 M42 K46 V94 N95 T96 Y113 S135 T136 R353 G11 Y12 V13 D34 M35 K39 V87 N88 T89 Y106 S128 T129 R346 T136 E172 K227 N231 C283 D287 T129 E165 K220 N224 C276 D280 1.1.1.22 0002009,0003979,0005634,0005737,0006024,0006065,0009792,0016491,0016616,0018991,0022414,0040025,0042802,0051287 Q19905 31616809 500 KVSKVVCVGAGYVGGPTCAMIAHKCPHITVTVVDMNTAKIAEWNSDKLPIYEPGLDEIVFAARGRNLFFSSDIPKAIAEADLIFISVNTPTKMYGRGKGMAPDLKYVESVSRTIAQYAGGPKIVVEKSTVPVKAAESIGCILREAQKNNENLKFQVLSNPEFLAEGTAMKDLANPDRVLIGGESSPEGLQAVAELVRIYENWVPRNRIITTNTWSSELSKLVANAFLAQRISSINSISAVCEATGAEISEVAHAVGYDTRIGSKFLQASVGFGGSCFQKDVLSLVYLCESLNLPQVADYWQGVININNWQRRRFADKIIAELFNTVTDKKIAIFGFAFKKNTGDTRESSAIHVIKHLMEEHAKLSVYDPKVQKSQMLNDLASVTSAQDVERLITVESDPYAAARGAHAIVVLTEWDEFVELNYSQIHNDMQHPAAIFDGRLILDQKALREIGFRTFAIGTSPD 6om8 C 2.449 BS02 UDX C 2 F169 L170 A171 E172 K227 I238 F272 Q274 S276 F279 G280 C283 F284 F345 K346 R447 F162 L163 A164 E165 K220 I231 F265 Q267 S269 F272 G273 C276 F277 F338 K339 R440 T136 E172 K227 N231 C283 D287 T129 E165 K220 N224 C276 D280 1.1.1.22 0002009,0003979,0005634,0005737,0006024,0006065,0009792,0016491,0016616,0018991,0022414,0040025,0042802,0051287 Q19905 31616809 501 KVSKVVCVGAGYVGGPTCAMIAHKCPHITVTVVDMNTAKIAEWNSDKLPIYEPGLDEIVFAARGRNLFFSSDIPKAIAEADLIFISVNTPTKMYGRGKGMAPDLKYVESVSRTIAQYAGGPKIVVEKSTVPVKAAESIGCILREAQKNNENLKFQVLSNPEFLAEGTAMKDLANPDRVLIGGESSPEGLQAVAELVRIYENWVPRNRIITTNTWSSELSKLVANAFLAQRISSINSISAVCEATGAEISEVAHAVGYDTRIGSKFLQASVGFGGSCFQKDVLSLVYLCESLNLPQVADYWQGVININNWQRRRFADKIIAELFNTVTDKKIAIFGFAFKKNTGDTRESSAIHVIKHLMEEHAKLSVYDPKVQKSQMLNDLASVTSAQDVERLITVESDPYAAARGAHAIVVLTEWDEFVELNYSQIHNDMQHPAAIFDGRLILDQKALREIGFRTFAIGTSPD 6om8 D 2.449 BS01 UDX D 1 G18 Y19 V20 D41 M42 K46 V94 N95 T96 Y113 S135 T136 K286 R353 G17 Y18 V19 D40 M41 K45 V93 N94 T95 Y112 S134 T135 K285 R352 T136 E172 K227 N231 C283 D287 T135 E171 K226 N230 C282 D286 1.1.1.22 0002009,0003979,0005634,0005737,0006024,0006065,0009792,0016491,0016616,0018991,0022414,0040025,0042802,0051287 Q19905 31616809 500 TDQVFGKVSKVVCVGAGYVGGPTCAMIAHKCPHITVTVVDMNTAKIAEWNSDKLPIYEPGLDEIVFAARGRNLFFSSDIPKAIAEADLIFISVNTPTKMYGRGKGMAPDLKYVESVSRTIAQYAGGPKIVVEKSTVPVKAAESIGCILREAQKNNENLKFQVLSNPEFLAEGTAMKDLANPDRVLIGGESSPEGLQAVAELVRIYENWVPRNRIITTNTWSSELSKLVANAFLAQRISSINSISAVCEATGAEISEVAHAVGYDTRIGSKFLQASVGFGGSCFQKDVLSLVYLCESLNLPQVADYWQGVININNWQRRRFADKIIAELFNTVTDKKIAIFGFAFKKNTGDTRESSAIHVIKHLMEEHAKLSVYDPKVQKSQMLNDLASVTSAQDVERLITVESDPYAAARGAHAIVVLTEWDEFVELNYSQIHNDMQHPAAIFDGRLILDQKALREIGFRTFAIGTSP 6om8 D 2.449 BS02 UDX D 2 F169 L170 A171 K227 I238 F272 Q274 S276 F279 G280 C283 F284 F345 K346 R447 F168 L169 A170 K226 I237 F271 Q273 S275 F278 G279 C282 F283 F344 K345 R446 T136 E172 K227 N231 C283 D287 T135 E171 K226 N230 C282 D286 1.1.1.22 0002009,0003979,0005634,0005737,0006024,0006065,0009792,0016491,0016616,0018991,0022414,0040025,0042802,0051287 Q19905 31616809 501 TDQVFGKVSKVVCVGAGYVGGPTCAMIAHKCPHITVTVVDMNTAKIAEWNSDKLPIYEPGLDEIVFAARGRNLFFSSDIPKAIAEADLIFISVNTPTKMYGRGKGMAPDLKYVESVSRTIAQYAGGPKIVVEKSTVPVKAAESIGCILREAQKNNENLKFQVLSNPEFLAEGTAMKDLANPDRVLIGGESSPEGLQAVAELVRIYENWVPRNRIITTNTWSSELSKLVANAFLAQRISSINSISAVCEATGAEISEVAHAVGYDTRIGSKFLQASVGFGGSCFQKDVLSLVYLCESLNLPQVADYWQGVININNWQRRRFADKIIAELFNTVTDKKIAIFGFAFKKNTGDTRESSAIHVIKHLMEEHAKLSVYDPKVQKSQMLNDLASVTSAQDVERLITVESDPYAAARGAHAIVVLTEWDEFVELNYSQIHNDMQHPAAIFDGRLILDQKALREIGFRTFAIGTSP 6om8 E 2.449 BS01 UDX E 1 G18 Y19 V20 D41 M42 K46 V94 N95 T96 Y113 S135 T136 R353 G11 Y12 V13 D34 M35 K39 V87 N88 T89 Y104 S126 T127 R344 T136 E172 K227 N231 C283 D287 T127 E163 K218 N222 C274 D278 1.1.1.22 0002009,0003979,0005634,0005737,0006024,0006065,0009792,0016491,0016616,0018991,0022414,0040025,0042802,0051287 Q19905 31616809 500 KVSKVVCVGAGYVGGPTCAMIAHKCPHITVTVVDMNTAKIAEWNSDKLPIYEPGLDEIVFAARGRNLFFSSDIPKAIAEADLIFISVNTPTKMRGKGMAPDLKYVESVSRTIAQYAGGPKIVVEKSTVPVKAAESIGCILREAQKNNENLKFQVLSNPEFLAEGTAMKDLANPDRVLIGGESSPEGLQAVAELVRIYENWVPRNRIITTNTWSSELSKLVANAFLAQRISSINSISAVCEATGAEISEVAHAVGYDTRIGSKFLQASVGFGGSCFQKDVLSLVYLCESLNLPQVADYWQGVININNWQRRRFADKIIAELFNTVTDKKIAIFGFAFKKNTGDTRESSAIHVIKHLMEEHAKLSVYDPKVQKSQMLNDLASVTSAQDVERLITVESDPYAAARGAHAIVVLTEWDEFVELNYSQIHNDMQHPAAIFDGRLILDQKALREIGFRTFAIGTSPD 6om8 E 2.449 BS02 UDX E 2 F169 L170 A171 K227 I238 F272 Q274 S276 F279 G280 C283 F284 F345 K346 R447 F160 L161 A162 K218 I229 F263 Q265 S267 F270 G271 C274 F275 F336 K337 R438 T136 E172 K227 N231 C283 D287 T127 E163 K218 N222 C274 D278 1.1.1.22 0002009,0003979,0005634,0005737,0006024,0006065,0009792,0016491,0016616,0018991,0022414,0040025,0042802,0051287 Q19905 31616809 501 KVSKVVCVGAGYVGGPTCAMIAHKCPHITVTVVDMNTAKIAEWNSDKLPIYEPGLDEIVFAARGRNLFFSSDIPKAIAEADLIFISVNTPTKMRGKGMAPDLKYVESVSRTIAQYAGGPKIVVEKSTVPVKAAESIGCILREAQKNNENLKFQVLSNPEFLAEGTAMKDLANPDRVLIGGESSPEGLQAVAELVRIYENWVPRNRIITTNTWSSELSKLVANAFLAQRISSINSISAVCEATGAEISEVAHAVGYDTRIGSKFLQASVGFGGSCFQKDVLSLVYLCESLNLPQVADYWQGVININNWQRRRFADKIIAELFNTVTDKKIAIFGFAFKKNTGDTRESSAIHVIKHLMEEHAKLSVYDPKVQKSQMLNDLASVTSAQDVERLITVESDPYAAARGAHAIVVLTEWDEFVELNYSQIHNDMQHPAAIFDGRLILDQKALREIGFRTFAIGTSPD 6om8 F 2.449 BS01 UDX F 1 G18 Y19 V20 D41 M42 K46 V94 N95 T96 Y113 S135 T136 R353 G12 Y13 V14 D35 M36 K40 V88 N89 T90 Y107 S129 T130 R347 T136 E172 K227 N231 C283 D287 T130 E166 K221 N225 C277 D281 1.1.1.22 0002009,0003979,0005634,0005737,0006024,0006065,0009792,0016491,0016616,0018991,0022414,0040025,0042802,0051287 Q19905 31616809 500 GKVSKVVCVGAGYVGGPTCAMIAHKCPHITVTVVDMNTAKIAEWNSDKLPIYEPGLDEIVFAARGRNLFFSSDIPKAIAEADLIFISVNTPTKMYGRGKGMAPDLKYVESVSRTIAQYAGGPKIVVEKSTVPVKAAESIGCILREAQKNNENLKFQVLSNPEFLAEGTAMKDLANPDRVLIGGESSPEGLQAVAELVRIYENWVPRNRIITTNTWSSELSKLVANAFLAQRISSINSISAVCEATGAEISEVAHAVGYDTRIGSKFLQASVGFGGSCFQKDVLSLVYLCESLNLPQVADYWQGVININNWQRRRFADKIIAELFNTVTDKKIAIFGFAFKKNTGDTRESSAIHVIKHLMEEHAKLSVYDPKVQKSQMLNDLASVTSAQDVERLITVESDPYAAARGAHAIVVLTEWDEFVELNYSQIHNDMQHPAAIFDGRLILDQKALREIGFRTFAIGTSPDQ 6om8 F 2.449 BS02 UDX F 2 F169 L170 A171 K227 I238 F272 Q274 S276 F279 G280 C283 F284 F345 K346 R447 F163 L164 A165 K221 I232 F266 Q268 S270 F273 G274 C277 F278 F339 K340 R441 T136 E172 K227 N231 C283 D287 T130 E166 K221 N225 C277 D281 1.1.1.22 0002009,0003979,0005634,0005737,0006024,0006065,0009792,0016491,0016616,0018991,0022414,0040025,0042802,0051287 Q19905 31616809 501 GKVSKVVCVGAGYVGGPTCAMIAHKCPHITVTVVDMNTAKIAEWNSDKLPIYEPGLDEIVFAARGRNLFFSSDIPKAIAEADLIFISVNTPTKMYGRGKGMAPDLKYVESVSRTIAQYAGGPKIVVEKSTVPVKAAESIGCILREAQKNNENLKFQVLSNPEFLAEGTAMKDLANPDRVLIGGESSPEGLQAVAELVRIYENWVPRNRIITTNTWSSELSKLVANAFLAQRISSINSISAVCEATGAEISEVAHAVGYDTRIGSKFLQASVGFGGSCFQKDVLSLVYLCESLNLPQVADYWQGVININNWQRRRFADKIIAELFNTVTDKKIAIFGFAFKKNTGDTRESSAIHVIKHLMEEHAKLSVYDPKVQKSQMLNDLASVTSAQDVERLITVESDPYAAARGAHAIVVLTEWDEFVELNYSQIHNDMQHPAAIFDGRLILDQKALREIGFRTFAIGTSPDQ 6om8 G 2.449 BS01 UDX G 1 G18 Y19 V20 D41 M42 K46 V94 N95 T96 Y113 S135 T136 K286 R353 G11 Y12 V13 D34 M35 K39 V87 N88 T89 Y106 S128 T129 K279 R346 T136 E172 K227 N231 C283 D287 T129 E165 K220 N224 C276 D280 1.1.1.22 0002009,0003979,0005634,0005737,0006024,0006065,0009792,0016491,0016616,0018991,0022414,0040025,0042802,0051287 Q19905 31616809 500 KVSKVVCVGAGYVGGPTCAMIAHKCPHITVTVVDMNTAKIAEWNSDKLPIYEPGLDEIVFAARGRNLFFSSDIPKAIAEADLIFISVNTPTKMYGRGKGMAPDLKYVESVSRTIAQYAGGPKIVVEKSTVPVKAAESIGCILREAQKNNENLKFQVLSNPEFLAEGTAMKDLANPDRVLIGGESSPEGLQAVAELVRIYENWVPRNRIITTNTWSSELSKLVANAFLAQRISSINSISAVCEATGAEISEVAHAVGYDTRIGSKFLQASVGFGGSCFQKDVLSLVYLCESLNLPQVADYWQGVININNWQRRRFADKIIAELFNTVTDKKIAIFGFAFKKNTGDTRESSAIHVIKHLMEEHAKLSVYDPKVQKSQMLNDLASVTSAQDVERLITVESDPYAAARGAHAIVVLTEWDEFVELNYSQIHNDMQHPAAIFDGRLILDQKALREIGFRTFAIGTSP 6om8 G 2.449 BS02 UDX G 2 F169 L170 A171 E172 K227 I238 F272 Q274 S276 F279 G280 C283 F284 F345 K346 R447 F162 L163 A164 E165 K220 I231 F265 Q267 S269 F272 G273 C276 F277 F338 K339 R440 T136 E172 K227 N231 C283 D287 T129 E165 K220 N224 C276 D280 1.1.1.22 0002009,0003979,0005634,0005737,0006024,0006065,0009792,0016491,0016616,0018991,0022414,0040025,0042802,0051287 Q19905 31616809 501 KVSKVVCVGAGYVGGPTCAMIAHKCPHITVTVVDMNTAKIAEWNSDKLPIYEPGLDEIVFAARGRNLFFSSDIPKAIAEADLIFISVNTPTKMYGRGKGMAPDLKYVESVSRTIAQYAGGPKIVVEKSTVPVKAAESIGCILREAQKNNENLKFQVLSNPEFLAEGTAMKDLANPDRVLIGGESSPEGLQAVAELVRIYENWVPRNRIITTNTWSSELSKLVANAFLAQRISSINSISAVCEATGAEISEVAHAVGYDTRIGSKFLQASVGFGGSCFQKDVLSLVYLCESLNLPQVADYWQGVININNWQRRRFADKIIAELFNTVTDKKIAIFGFAFKKNTGDTRESSAIHVIKHLMEEHAKLSVYDPKVQKSQMLNDLASVTSAQDVERLITVESDPYAAARGAHAIVVLTEWDEFVELNYSQIHNDMQHPAAIFDGRLILDQKALREIGFRTFAIGTSP 6om8 H 2.449 BS01 UDX H 1 G18 Y19 V20 D41 M42 K46 V94 N95 T96 Y113 S135 T136 R353 G11 Y12 V13 D34 M35 K39 V87 N88 T89 Y106 S128 T129 R346 T136 E172 K227 N231 C283 D287 T129 E165 K220 N224 C276 D280 1.1.1.22 0002009,0003979,0005634,0005737,0006024,0006065,0009792,0016491,0016616,0018991,0022414,0040025,0042802,0051287 Q19905 31616809 500 KVSKVVCVGAGYVGGPTCAMIAHKCPHITVTVVDMNTAKIAEWNSDKLPIYEPGLDEIVFAARGRNLFFSSDIPKAIAEADLIFISVNTPTKMYGRGKGMAPDLKYVESVSRTIAQYAGGPKIVVEKSTVPVKAAESIGCILREAQKNNENLKFQVLSNPEFLAEGTAMKDLANPDRVLIGGESSPEGLQAVAELVRIYENWVPRNRIITTNTWSSELSKLVANAFLAQRISSINSISAVCEATGAEISEVAHAVGYDTRIGSKFLQASVGFGGSCFQKDVLSLVYLCESLNLPQVADYWQGVININNWQRRRFADKIIAELFNTVTDKKIAIFGFAFKKNTGDTRESSAIHVIKHLMEEHAKLSVYDPKVQKSQMLNDLASVTSAQDVERLITVESDPYAAARGAHAIVVLTEWDEFVELNYSQIHNDMQHPAAIFDGRLILDQKALREIGFRTFAIGTSP 6om8 H 2.449 BS02 UDX H 2 F169 L170 A171 E172 K227 I238 F272 Q274 S276 F279 G280 C283 F284 F345 K346 R447 F162 L163 A164 E165 K220 I231 F265 Q267 S269 F272 G273 C276 F277 F338 K339 R440 T136 E172 K227 N231 C283 D287 T129 E165 K220 N224 C276 D280 1.1.1.22 0002009,0003979,0005634,0005737,0006024,0006065,0009792,0016491,0016616,0018991,0022414,0040025,0042802,0051287 Q19905 31616809 501 KVSKVVCVGAGYVGGPTCAMIAHKCPHITVTVVDMNTAKIAEWNSDKLPIYEPGLDEIVFAARGRNLFFSSDIPKAIAEADLIFISVNTPTKMYGRGKGMAPDLKYVESVSRTIAQYAGGPKIVVEKSTVPVKAAESIGCILREAQKNNENLKFQVLSNPEFLAEGTAMKDLANPDRVLIGGESSPEGLQAVAELVRIYENWVPRNRIITTNTWSSELSKLVANAFLAQRISSINSISAVCEATGAEISEVAHAVGYDTRIGSKFLQASVGFGGSCFQKDVLSLVYLCESLNLPQVADYWQGVININNWQRRRFADKIIAELFNTVTDKKIAIFGFAFKKNTGDTRESSAIHVIKHLMEEHAKLSVYDPKVQKSQMLNDLASVTSAQDVERLITVESDPYAAARGAHAIVVLTEWDEFVELNYSQIHNDMQHPAAIFDGRLILDQKALREIGFRTFAIGTSP 6om8 I 2.449 BS01 UDX I 1 G18 Y19 V20 D41 M42 K46 V94 N95 T96 Y113 S135 T136 R353 G11 Y12 V13 D34 M35 K39 V87 N88 T89 Y106 S128 T129 R346 T136 E172 K227 N231 C283 D287 T129 E165 K220 N224 C276 D280 1.1.1.22 0002009,0003979,0005634,0005737,0006024,0006065,0009792,0016491,0016616,0018991,0022414,0040025,0042802,0051287 Q19905 31616809 500 KVSKVVCVGAGYVGGPTCAMIAHKCPHITVTVVDMNTAKIAEWNSDKLPIYEPGLDEIVFAARGRNLFFSSDIPKAIAEADLIFISVNTPTKMYGRGKGMAPDLKYVESVSRTIAQYAGGPKIVVEKSTVPVKAAESIGCILREAQKNNENLKFQVLSNPEFLAEGTAMKDLANPDRVLIGGESSPEGLQAVAELVRIYENWVPRNRIITTNTWSSELSKLVANAFLAQRISSINSISAVCEATGAEISEVAHAVGYDTRIGSKFLQASVGFGGSCFQKDVLSLVYLCESLNLPQVADYWQGVININNWQRRRFADKIIAELFNTVTDKKIAIFGFAFKKNTGDTRESSAIHVIKHLMEEHAKLSVYDPKVQKSQMLNDLASVTSAQDVERLITVESDPYAAARGAHAIVVLTEWDEFVELNYSQIHNDMQHPAAIFDGRLILDQKALREIGFRTFAIGTSP 6om8 I 2.449 BS02 UDX I 2 F169 L170 A171 E172 K227 I238 F272 Q274 S276 F279 G280 C283 F284 F345 K346 R447 F162 L163 A164 E165 K220 I231 F265 Q267 S269 F272 G273 C276 F277 F338 K339 R440 T136 E172 K227 N231 C283 D287 T129 E165 K220 N224 C276 D280 1.1.1.22 0002009,0003979,0005634,0005737,0006024,0006065,0009792,0016491,0016616,0018991,0022414,0040025,0042802,0051287 Q19905 31616809 501 KVSKVVCVGAGYVGGPTCAMIAHKCPHITVTVVDMNTAKIAEWNSDKLPIYEPGLDEIVFAARGRNLFFSSDIPKAIAEADLIFISVNTPTKMYGRGKGMAPDLKYVESVSRTIAQYAGGPKIVVEKSTVPVKAAESIGCILREAQKNNENLKFQVLSNPEFLAEGTAMKDLANPDRVLIGGESSPEGLQAVAELVRIYENWVPRNRIITTNTWSSELSKLVANAFLAQRISSINSISAVCEATGAEISEVAHAVGYDTRIGSKFLQASVGFGGSCFQKDVLSLVYLCESLNLPQVADYWQGVININNWQRRRFADKIIAELFNTVTDKKIAIFGFAFKKNTGDTRESSAIHVIKHLMEEHAKLSVYDPKVQKSQMLNDLASVTSAQDVERLITVESDPYAAARGAHAIVVLTEWDEFVELNYSQIHNDMQHPAAIFDGRLILDQKALREIGFRTFAIGTSP 6om8 J 2.449 BS01 UDX J 1 G18 Y19 V20 D41 M42 K46 V94 N95 T96 Y113 S135 T136 R353 G18 Y19 V20 D41 M42 K46 V94 N95 T96 Y102 S124 T125 R340 T136 E172 K227 N231 C283 D287 T125 E159 K214 N218 C270 D274 1.1.1.22 0002009,0003979,0005634,0005737,0006024,0006065,0009792,0016491,0016616,0018991,0022414,0040025,0042802,0051287 Q19905 31616809 500 MTDQVFGKVSKVVCVGAGYVGGPTCAMIAHKCPHITVTVVDMNTAKIAEWNSDKLPIYEPGLDEIVFAARGRNLFFSSDIPKAIAEADLIFISVNTPTDLKYVESVSRTIAQYAGGPKIVVEKSTVPVKAAESIGCILREAQKNNLKFQVLSNPEFLAEGTAMKDLANPDRVLIGGESSPEGLQAVAELVRIYENWVPRNRIITTNTWSSELSKLVANAFLAQRISSINSISAVCEATGAEISEVAHAVGYDTRIGSKFLQASVGFGGSCFQKDVLSLVYLCESLNLPQVADYWQGVININNWQRRRFADKIIAELFNTVTDKKIAIFGFAFKKNTGDTRESSAIHVIKHLMEEHAKLSVYDPKVQKSQMLNDLASVTSAQDVERLITVESDPYAAARGAHAIVVLTEWDEFVELNYSQIHNDMQHPAAIFDGRLILDQKALREIGFRTFAIGTSP 6om8 J 2.449 BS02 UDX J 2 T136 F169 L170 A171 K227 I238 F272 Q274 S276 F279 G280 C283 F284 F345 K346 R447 T125 F156 L157 A158 K214 I225 F259 Q261 S263 F266 G267 C270 F271 F332 K333 R434 T136 E172 K227 N231 C283 D287 T125 E159 K214 N218 C270 D274 1.1.1.22 0002009,0003979,0005634,0005737,0006024,0006065,0009792,0016491,0016616,0018991,0022414,0040025,0042802,0051287 Q19905 31616809 501 MTDQVFGKVSKVVCVGAGYVGGPTCAMIAHKCPHITVTVVDMNTAKIAEWNSDKLPIYEPGLDEIVFAARGRNLFFSSDIPKAIAEADLIFISVNTPTDLKYVESVSRTIAQYAGGPKIVVEKSTVPVKAAESIGCILREAQKNNLKFQVLSNPEFLAEGTAMKDLANPDRVLIGGESSPEGLQAVAELVRIYENWVPRNRIITTNTWSSELSKLVANAFLAQRISSINSISAVCEATGAEISEVAHAVGYDTRIGSKFLQASVGFGGSCFQKDVLSLVYLCESLNLPQVADYWQGVININNWQRRRFADKIIAELFNTVTDKKIAIFGFAFKKNTGDTRESSAIHVIKHLMEEHAKLSVYDPKVQKSQMLNDLASVTSAQDVERLITVESDPYAAARGAHAIVVLTEWDEFVELNYSQIHNDMQHPAAIFDGRLILDQKALREIGFRTFAIGTSP 6om8 K 2.449 BS01 UDX K 1 G18 Y19 V20 D41 M42 K46 V94 N95 T96 Y113 S135 T136 R353 G11 Y12 V13 D34 M35 K39 V87 N88 T89 Y106 S128 T129 R346 T136 E172 K227 N231 C283 D287 T129 E165 K220 N224 C276 D280 1.1.1.22 0002009,0003979,0005634,0005737,0006024,0006065,0009792,0016491,0016616,0018991,0022414,0040025,0042802,0051287 Q19905 31616809 500 KVSKVVCVGAGYVGGPTCAMIAHKCPHITVTVVDMNTAKIAEWNSDKLPIYEPGLDEIVFAARGRNLFFSSDIPKAIAEADLIFISVNTPTKMYGRGKGMAPDLKYVESVSRTIAQYAGGPKIVVEKSTVPVKAAESIGCILREAQKNNENLKFQVLSNPEFLAEGTAMKDLANPDRVLIGGESSPEGLQAVAELVRIYENWVPRNRIITTNTWSSELSKLVANAFLAQRISSINSISAVCEATGAEISEVAHAVGYDTRIGSKFLQASVGFGGSCFQKDVLSLVYLCESLNLPQVADYWQGVININNWQRRRFADKIIAELFNTVTDKKIAIFGFAFKKNTGDTRESSAIHVIKHLMEEHAKLSVYDPKVQKSQMLNDLASVTSAQDVERLITVESDPYAAARGAHAIVVLTEWDEFVELNYSQIHNDMQHPAAIFDGRLILDQKALREIGFRTFAIGTSPDQ 6om8 K 2.449 BS02 UDX K 2 F169 L170 A171 E172 K227 I238 F272 Q274 S276 F279 G280 C283 F284 F345 K346 R447 F162 L163 A164 E165 K220 I231 F265 Q267 S269 F272 G273 C276 F277 F338 K339 R440 T136 E172 K227 N231 C283 D287 T129 E165 K220 N224 C276 D280 1.1.1.22 0002009,0003979,0005634,0005737,0006024,0006065,0009792,0016491,0016616,0018991,0022414,0040025,0042802,0051287 Q19905 31616809 501 KVSKVVCVGAGYVGGPTCAMIAHKCPHITVTVVDMNTAKIAEWNSDKLPIYEPGLDEIVFAARGRNLFFSSDIPKAIAEADLIFISVNTPTKMYGRGKGMAPDLKYVESVSRTIAQYAGGPKIVVEKSTVPVKAAESIGCILREAQKNNENLKFQVLSNPEFLAEGTAMKDLANPDRVLIGGESSPEGLQAVAELVRIYENWVPRNRIITTNTWSSELSKLVANAFLAQRISSINSISAVCEATGAEISEVAHAVGYDTRIGSKFLQASVGFGGSCFQKDVLSLVYLCESLNLPQVADYWQGVININNWQRRRFADKIIAELFNTVTDKKIAIFGFAFKKNTGDTRESSAIHVIKHLMEEHAKLSVYDPKVQKSQMLNDLASVTSAQDVERLITVESDPYAAARGAHAIVVLTEWDEFVELNYSQIHNDMQHPAAIFDGRLILDQKALREIGFRTFAIGTSPDQ 6om8 L 2.449 BS01 UDX L 1 G18 Y19 V20 D41 M42 K46 V94 N95 T96 Y113 S135 T136 K286 R353 G12 Y13 V14 D35 M36 K40 V88 N89 T90 Y107 S129 T130 K280 R347 T136 E172 K227 N231 C283 D287 T130 E166 K221 N225 C277 D281 1.1.1.22 0002009,0003979,0005634,0005737,0006024,0006065,0009792,0016491,0016616,0018991,0022414,0040025,0042802,0051287 Q19905 31616809 500 GKVSKVVCVGAGYVGGPTCAMIAHKCPHITVTVVDMNTAKIAEWNSDKLPIYEPGLDEIVFAARGRNLFFSSDIPKAIAEADLIFISVNTPTKMYGRGKGMAPDLKYVESVSRTIAQYAGGPKIVVEKSTVPVKAAESIGCILREAQKNNENLKFQVLSNPEFLAEGTAMKDLANPDRVLIGGESSPEGLQAVAELVRIYENWVPRNRIITTNTWSSELSKLVANAFLAQRISSINSISAVCEATGAEISEVAHAVGYDTRIGSKFLQASVGFGGSCFQKDVLSLVYLCESLNLPQVADYWQGVININNWQRRRFADKIIAELFNTVTDKKIAIFGFAFKKNTGDTRESSAIHVIKHLMEEHAKLSVYDPKVQKSQMLNDLASVTSAQDVERLITVESDPYAAARGAHAIVVLTEWDEFVELNYSQIHNDMQHPAAIFDGRLILDQKALREIGFRTFAIGTSP 6om8 L 2.449 BS02 UDX L 2 E168 F169 L170 A171 E172 K227 I238 F272 Q274 S276 F279 G280 C283 F284 F345 K346 R447 E162 F163 L164 A165 E166 K221 I232 F266 Q268 S270 F273 G274 C277 F278 F339 K340 R441 T136 E172 K227 N231 C283 D287 T130 E166 K221 N225 C277 D281 1.1.1.22 0002009,0003979,0005634,0005737,0006024,0006065,0009792,0016491,0016616,0018991,0022414,0040025,0042802,0051287 Q19905 31616809 501 GKVSKVVCVGAGYVGGPTCAMIAHKCPHITVTVVDMNTAKIAEWNSDKLPIYEPGLDEIVFAARGRNLFFSSDIPKAIAEADLIFISVNTPTKMYGRGKGMAPDLKYVESVSRTIAQYAGGPKIVVEKSTVPVKAAESIGCILREAQKNNENLKFQVLSNPEFLAEGTAMKDLANPDRVLIGGESSPEGLQAVAELVRIYENWVPRNRIITTNTWSSELSKLVANAFLAQRISSINSISAVCEATGAEISEVAHAVGYDTRIGSKFLQASVGFGGSCFQKDVLSLVYLCESLNLPQVADYWQGVININNWQRRRFADKIIAELFNTVTDKKIAIFGFAFKKNTGDTRESSAIHVIKHLMEEHAKLSVYDPKVQKSQMLNDLASVTSAQDVERLITVESDPYAAARGAHAIVVLTEWDEFVELNYSQIHNDMQHPAAIFDGRLILDQKALREIGFRTFAIGTSP 6tec A 2.4 BS01 UDX A 1 V44 A45 T46 W75 V80 T83 V84 G85 D112 S113 Y114 D115 W145 G256 K259 V12 A13 T14 W43 V48 T51 V52 G53 D80 S81 Y82 D83 W113 G224 K227 1.14.11.4,2.4.1.50,2.4.1.66 0001701,0001886,0005506,0005515,0005576,0005615,0005783,0005788,0005789,0005791,0005794,0005802,0006493,0008104,0008475,0016020,0016705,0016757,0017185,0021915,0030199,0031418,0032963,0033823,0036094,0042311,0046872,0046947,0048730,0050211,0051213,0060425,0062023,0070062,0070831 O60568 801 PVNPEKLLVITVATAETEGYLRFLRSAEFFNYTVRTLGLGEEWRGGDVARTVGGGQKVRWLKKEMEKYADREDMIIMFVDSYDVILAGSPTELLKKFVQSGSRLLFSAESFCWPEWGLAEQYPEVGTGKRFLNSGGFIGFATTIHQIVRQWKYKDDDDDQLFYTRLYLDPGLREKLSLNLDHKSRIFQNLNGALDEVVLKFDRNRVRIRNVAYDTLPIVVHGNGPTKLQLNYLGNYVPNGWTPEGGCGFCNQDRQPPPRVFLAVFVEQPTPFLPRFLQRLLLLDYPPDRVTLFLHNNEVFHEPHIADSWPQLQDHFSAVKLVGPEEALSPGEARDMAMDLCRQDPECEFYFSLDADAVLTNLQTLRILIEENRKVIAPMLSRHGKLWSNFWGALSPDEYYARSEDYVELVQRKRVGVWNVPYISQAYVIRGDTLRMELPQRDVFSGSDTDPDMAFCKSFRDKGIFLHLSNQHEFGRLLATSRYDTEHLHPDLWQIFDNPVDWKEQYIHENYSRALEGEGIVEQPCPDVYWFPLLSEQMCDELVAEMEHYGQWSGGRHEDSRLAGGYENVPTVDIHMKQVGYEDQWLQLLRTYVGPMTESLFPGYHTKARAVMNFVVRYRPDEQPSLRPHHDSSTFTLNVALNHKGLDYEGGGCRFLRYDCVISSPRKGWALLHPGRLTHYHEGLPTTWGTRYIMVSFVDP 8avq A 2.0 BS01 UDX A 1 D73 N148 T150 N153 R158 E177 H183 F186 G203 T206 H207 R208 E211 D76 N151 T153 N156 R161 E180 H186 F189 G206 T209 H210 R211 E214 ? 0046872 Q89410 304 LGSMKLAELTLESDDFITSDKLFNFCKSTIFGAKYVKTDFIKFRQYQYIVSNCGWRDDTDVVFLENTPVLVTGHSDYDISEREIDIIRLPNIRAWFCQNRNIPHPKVISFPLGITNKDEPNSEIHRIIGNTDRILEVSKTPKEIKNLVYMNITVKNFPEERQRIVDLYSDKSWVTIGKGEVSEEGHRKFLEDMYAHKFCFAPRGNGIDTHRLWESLYLRTIPIVKKHIAMEQFTDLPILFVNDWENITEEYLNEQYDIIMAKDWNLDKLKIDYWYQKILEY 8avq B 2.0 BS01 UDX B 1 D73 N148 T150 N153 R158 E177 H183 F186 G203 T206 R208 E211 D76 N151 T153 N156 R161 E180 H186 F189 G206 T209 R211 E214 ? 0046872 Q89410 303 LGSMKLAELTLESDDFITSDKLFNFCKSTIFGAKYVKTDFIKFRQYQYIVSNCGWRDDTDVVFLENTPVLVTGHSDYDISEREIDIIRLPNIRAWFCQNRNIPHPKVISFPLGITNKDEPNSEIHRIIGNTDRILEVSKTPKEIKNLVYMNITVKNFPEERQRIVDLYSDKSWVTIGKGEVSEEGHRKFLEDMYAHKFCFAPRGNGIDTHRLWESLYLRTIPIVKKHIAMEQFTDLPILFVNDWENITEEYLNEQYDIIMAKDWNLDKLKIDYWYQKILEYS 8avq C 2.0 BS01 UDX C 1 D73 N148 T150 N153 R158 E177 F186 G203 T206 H207 R208 E211 D74 N149 T151 N154 R159 E178 F187 G204 T207 H208 R209 E212 ? 0046872 Q89410 306 SMKLAELTLESDDFITSDKLFNFCKSTIFGAKYVKTDFIKFRQYQYIVSNCGWRDDTDVVFLENTPVLVTGHSDYDISEREIDIIRLPNIRAWFCQNRNIPHPKVISFPLGITNKDEPNSEIHRIIGNTDRILEVSKTPKEIKNLVYMNITVKNFPEERQRIVDLYSDKSWVTIGKGEVSEEGHRKFLEDMYAHKFCFAPRGNGIDTHRLWESLYLRTIPIVKKHIAMEQFTDLPILFVNDWENITEEYLNEQYDIIMAKDWNLDKLKIDYWYQKILEYS 8avq D 2.0 BS01 UDX D 1 D73 N148 T150 N153 R158 E177 H183 F186 G203 T206 H207 R208 E211 D73 N148 T150 N153 R158 E177 H183 F186 G203 T206 H207 R208 E211 ? 0046872 Q89410 304 SMKLAELTLESDDFITSDKLFNFCKSTFGAKYVKTDFIKFRQYQYIVSNCGWRDDTDVVFLENTPVLVTGHSDYDISEREIDIIRLPNIRAWFCQNRNIPHPKVISFPLGITNKDEPNSEIHRIIGNTDRILEVSKTPKEIKNLVYMNITVKNFPEERQRIVDLYSDKSWVTIGKGEVSEEGHRKFLEDMYAHKFCFAPRGNGIDTHRLWESLYLRTIPIVKKHIAMEQFTDLPILFVNDWENITEEYLNEQYDIIMAKDWNLDKLKIDYWYQKILEYS