1nvq A 2.0 BS02 UCN A 1 L15 G16 V23 A36 K38 V68 E85 Y86 C87 G90 E91 E134 L137 S147 D148 L13 G14 V21 A34 K36 V59 E76 Y77 C78 G81 E82 E125 L128 S138 D139 D130 K132 E134 N135 D148 T170 D121 K123 E125 N126 D139 T161 2.7.11.1 0000077,0004672,0004674,0005524,0006468 Ki=5.6nM -logKd/Ki=8.25, Ki=5.6nM IC50=9.9nM, Ki=5.6nM O14757 12244092 400 VPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKNIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKKGA 1okz A 2.51 BS01 UCN A 1 L88 G89 V96 A109 K111 L159 Y161 A162 G165 E166 E209 N210 L212 T222 D223 L16 G17 V24 A37 K39 L87 Y89 A90 G93 E94 E137 N138 L140 T150 D151 D205 K207 E209 N210 D223 T245 D133 K135 E137 N138 D151 T164 2.7.11.1 0004672,0004674,0005524,0006468 -logKd/Ki=8.30, IC50=5nM O15530 12892559 1370 QPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLNSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPKL 1pkd A 2.3 BS01 UCN A 1 I10 G11 A31 K33 F80 E81 F82 L83 H84 D86 Q131 L134 I11 G12 A32 K34 F81 E82 F83 L84 H85 D87 Q132 L135 D127 K129 Q131 N132 D145 T158 T165 D128 K130 Q132 N133 D146 T159 T166 2.7.11.22 0000082,0000086,0000122,0000287,0000307,0000781,0000793,0000805,0000806,0001673,0004672,0004674,0004693,0005515,0005524,0005634,0005635,0005654,0005667,0005737,0005768,0005813,0005829,0005856,0006260,0006281,0006338,0006351,0006468,0006813,0007099,0007165,0007265,0007346,0008284,0010389,0010468,0015030,0016301,0016310,0018105,0019904,0030332,0031453,0031571,0032298,0035173,0043247,0043687,0045740,0045893,0046872,0051298,0051301,0051321,0071732,0090398,0097123,0097124,0097134,0097135,0097472,0106310,1905784 Ki=30nM P24941 410 SMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHL 1pkd C 2.3 BS01 UCN C 1 I10 G11 V18 A31 K33 V64 F80 E81 F82 L83 H84 Q85 Q131 N132 L134 D145 I11 G12 V19 A32 K34 V65 F81 E82 F83 L84 H85 Q86 Q132 N133 L135 D146 D127 K129 Q131 N132 D145 T158 T165 D128 K130 Q132 N133 D146 T159 T166 2.7.11.22 0000082,0000086,0000122,0000287,0000307,0000781,0000793,0000805,0000806,0001673,0004672,0004674,0004693,0005515,0005524,0005634,0005635,0005654,0005667,0005737,0005768,0005813,0005829,0005856,0006260,0006281,0006338,0006351,0006468,0006813,0007099,0007165,0007265,0007346,0008284,0010389,0010468,0015030,0016301,0016310,0018105,0019904,0030332,0031453,0031571,0032298,0035173,0043247,0043687,0045740,0045893,0046872,0051298,0051301,0051321,0071732,0090398,0097123,0097124,0097134,0097135,0097472,0106310,1905784 Ki=30nM P24941 411 SMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHL 7oub B 1.82 BS01 UCN B 1 Y27 Y37 V41 F49 L62 E64 L79 V88 R90 A99 F112 Y127 Y29 Y39 V43 F51 L64 E66 L81 V90 R92 A101 F114 Y129 ? 0002682,0005515,0005576,0005615,0006953,0031093,0032731,0032732,0032760,0035578,0035580,0062023,0070062,0072562 P19652 34758357 201 GPQIPLCANLVPVPITNATLDRITGKWFYIASAFRNEEYNKSVQEIQATFFYFTPNKTEDTIFLREYQTRQNQCFYNSSYLNVQRENGTVSRYEGGREHVAHLLFLRDTKTLMFGSYLDDEKNWGLSFYADKPETTKEQLGEFYEALDCLRIPRSDVMYTDWKKDKCEPLEKQ