2i4t A 2.74 BS01 UA2 A 1 M64 T90 C91 G92 F159 E179 M180 E181 D204 M64 T90 C91 G92 F159 E179 M180 E181 D204 H4 G20 R24 R43 E75 R87 T90 S203 D204 I206 H4 G20 R24 R43 E75 R87 T90 S203 D204 I206 2.4.2.1 0003824,0004731,0004850,0005829,0006139,0006218,0009116 A2E7Y6 17223688 243 ATPHNSAQVGDFAETVLMCGDPLRAKLIAETYLENPKLVNNVRGIQGYTGTYKGKPISVMGHGMGLPSICIYAEELYSTYKVKTIIRVGTCGAIDMDIHTRDIVIFTSAGTNSKINRIRFMDHDYPATASFDVVCALVDAAKELNIPAKVGKGFSTDLFYNPQTELAQLMNKFHFLAVEMESAGLFPIADLYGARAGCICTVSDHILHHERQNSFQNMMKIALEAAIKLH 2i4t A 2.74 BS02 UA2 B 1 H4 R43 H4 R43 H4 G20 R24 R43 E75 R87 T90 S203 D204 I206 H4 G20 R24 R43 E75 R87 T90 S203 D204 I206 2.4.2.1 0003824,0004731,0004850,0005829,0006139,0006218,0009116 A2E7Y6 17223688 241 ATPHNSAQVGDFAETVLMCGDPLRAKLIAETYLENPKLVNNVRGIQGYTGTYKGKPISVMGHGMGLPSICIYAEELYSTYKVKTIIRVGTCGAIDMDIHTRDIVIFTSAGTNSKINRIRFMDHDYPATASFDVVCALVDAAKELNIPAKVGKGFSTDLFYNPQTELAQLMNKFHFLAVEMESAGLFPIADLYGARAGCICTVSDHILHHERQNSFQNMMKIALEAAIKLH 2i4t B 2.74 BS01 UA2 A 1 H4 R43 H4 R43 H4 G20 R24 R43 E75 R87 T90 S203 D204 I206 H4 G20 R24 R43 E75 R87 T90 S203 D204 I206 2.4.2.1 0003824,0004731,0004850,0005829,0006139,0006218,0009116 A2E7Y6 17223688 243 ATPHNSAQVGDFAETVLMCGDPLRAKLIAETYLENPKLVNNVRGIQGYTGTYKGKPISVMGHGMGLPSICIYAEELYSTYKVKTIIRVGTCGAIDMDIHTRDIVIFTSAGTNSKINRIRFMDHDYPATASFDVVCALVDAAKELNIPAKVGKGFSTDLFYNPQTELAQLMNKFHFLAVEMESAGLFPIADLYGARAGCICTVSDHILHHEETTAEERQNSFQNMMKIALEAAIKL 2i4t B 2.74 BS02 UA2 B 1 M64 T90 C91 F159 V178 E179 M180 E181 S203 D204 M64 T90 C91 F159 V178 E179 M180 E181 S203 D204 H4 G20 R24 R43 E75 R87 T90 S203 D204 I206 H4 G20 R24 R43 E75 R87 T90 S203 D204 I206 2.4.2.1 0003824,0004731,0004850,0005829,0006139,0006218,0009116 A2E7Y6 17223688 241 ATPHNSAQVGDFAETVLMCGDPLRAKLIAETYLENPKLVNNVRGIQGYTGTYKGKPISVMGHGMGLPSICIYAEELYSTYKVKTIIRVGTCGAIDMDIHTRDIVIFTSAGTNSKINRIRFMDHDYPATASFDVVCALVDAAKELNIPAKVGKGFSTDLFYNPQTELAQLMNKFHFLAVEMESAGLFPIADLYGARAGCICTVSDHILHHEETTAEERQNSFQNMMKIALEAAIKL 2i4t C 2.74 BS01 UA2 C 1 M64 T90 C91 F159 E179 M180 E181 D204 M64 T90 C91 F158 E178 M179 E180 D203 H4 G20 R24 R43 E75 R87 T90 S203 D204 I206 H4 G20 R24 R43 E75 R87 T90 S202 D203 I205 2.4.2.1 0003824,0004731,0004850,0005829,0006139,0006218,0009116 A2E7Y6 17223688 242 ATPHNSAQVGDFAETVLMCGDPLRAKLIAETYLENPKLVNNVRGIQGYTGTYKGKPISVMGHGMGLPSICIYAEELYSTYKVKTIIRVGTCGAIDMDIHTDIVIFTSAGTNSKINRIRFMDHDYPATASFDVVCALVDAAKELNIPAKVGKGFSTDLFYNPQTELAQLMNKFHFLAVEMESAGLFPIADLYGARAGCICTVSDHILHNSFQNMMKIALEAAIKL 4i72 A 2.05 BS02 UA2 A 1 N12 D14 D40 F79 W83 M164 E184 N186 R252 Y257 W260 D261 N15 D17 D43 F82 W86 M167 E187 N189 R255 Y260 W263 D264 3.2.2.1 0005829,0006139,0006152,0006166,0008477,0016798,0016799,0016810,0020015,0046872 Ki=0.9nM -logKd/Ki=9.05, Ki=0.9nM Q57ZL6 23897478 402 GSHMAKTVILDHDGNKDDFVAMILLLSNPKKVNLIGCICTDADCFVENGFDVTGKIMCAMHRLIKTPLFPIGKSTATAVNAFPTEWRFSAKNLDDMPFLNIVEDVALWEKLKPENEAHNGQQLLADLVMKSKEKVTVCVTGPLSNMAWCIEKYGEAFTSKVEECVIMGGAVDVGGNVFLPTTDGSAEWNIYWDPPAAKKVLCCPNIRCVLFSLDATNTVPVRSVDVKGFGAQNQYLLSQMVGTMWAMSTHEEILRDGDAYYAWDALTAAYILEPTIATLEPVALDVDVSKGKSEGRTPRASGKPCVHVARNPSKQMFHDLVFASTRVC 4i72 B 2.05 BS02 UA2 B 1 N12 D14 D40 W83 M164 E184 N186 R252 Y257 W260 D261 N15 D17 D43 W86 M167 E187 N189 R255 Y260 W263 D264 3.2.2.1 0005829,0006139,0006152,0006166,0008477,0016798,0016799,0016810,0020015,0046872 Ki=0.9nM Q57ZL6 23897478 402 GSHMAKTVILDHDGNKDDFVAMILLLSNPKKVNLIGCICTDADCFVENGFDVTGKIMCAMHRLIKTPLFPIGKSTATAVNAFPTEWRFSAKNLDDMPFLNIVEDVALWEKLKPENEAHNGQQLLADLVMKSKEKVTVCVTGPLSNMAWCIEKYGEAFTSKVEECVIMGGAVDVGGNVFLPTTDGSAEWNIYWDPPAAKKVLCCPNIRCVLFSLDATNTVPVRSVDVKGFGAQNQYLLSQMVGTMWAMSTHEEILRDGDAYYAWDALTAAYILEPTIATLEPVALDVDVSKGKSEGRTPRASGKPCVHVARNPSKQMFHDLVFASTRVC