3rz3 A 2.3 BS01 U94 A 1 I45 P48 T51 Y52 Y53 F58 I128 N132 Y161 I40 P43 T46 Y47 Y48 F53 I109 N113 Y142 C93 C88 2.3.2.23,2.3.2.24 ic50=1.72uM -logKd/Ki=5.76, IC50=1.72uM P49427 21683433 1 SPSSQKALLLELKGLQEEPVEGFRVTLVDEGDLYNWEVAIFGPPNTYYEGGYFKARLKFPIDYPYSPPAFRFLTKMWHPNIYETGDVCISILERWNPTQNVRTILLSVISLLNEPNTFSPANVDASVMYRKWKESKGKDREYTDIIRKQVLGTKVDAERDGVKV 3rz3 B 2.3 BS01 U94 B 1 I45 P48 N50 T51 Y52 Y53 F58 I128 L131 I40 P43 N45 T46 Y47 Y48 F53 I109 L112 C93 C88 2.3.2.23,2.3.2.24 ic50=1.72uM P49427 21683433 1 SPSSQKALLLELKGLQEEPVEGFRVTLVDEGDLYNWEVAIFGPPNTYYEGGYFKARLKFPIDYPYSPPAFRFLTKMWHPNIYETGDVCISILERWNPTQNVRTILLSVISLLNEPNTFSPANVDASVMYRKWKESKGKDREYTDIIRKQVLGTKVDAERDGVKV 3rz3 C 2.3 BS01 U94 C 1 I45 P48 N50 T51 Y52 Y53 F58 I128 L131 N132 Y161 I37 P40 N42 T43 Y44 Y45 F50 I102 L105 N106 Y135 C93 C85 2.3.2.23,2.3.2.24 ic50=1.72uM P49427 21683433 1 SQKALLLELKGLQEEPVEGFRVTLVDEGDLYNWEVAIFGPPNTYYEGGYFKARLKFPIDYPYSPPAFRFLTKMWHPNIYETGDVCIRWNPTQNVRTILLSVISLLNEPNTFSPANVDASVMYRKWKESKGKDREYTDIIRKQVLGTKVDAERDGVK 3rz3 D 2.3 BS01 U94 D 1 I45 P48 T51 Y52 Y53 F58 L131 N132 I33 P36 T39 Y40 Y41 F46 L94 N95 C93 C81 2.3.2.23,2.3.2.24 ic50=1.72uM P49427 21683433 1 LLLELKGLQEEPVEGFRVTLVDEGDLYNWEVAIFGPPNTYYEGGYFKARLKFPIDYPYSPPAFRFLTKMWHPNIYETGDVCNVRTILLSVISLLNEPNTFSPANVDASVMYRKWKESKGKDREYTDIIRKQVLGTKVDAERDGVKV 4mdk A 2.6095 BS01 U94 A 1 P48 T51 Y52 Y53 F58 L131 N132 W151 Y161 P42 T45 Y46 Y47 F52 L115 N116 W135 Y145 C93 C87 2.3.2.23,2.3.2.24 P49427 24316736 201 PSSQKALLLELKGLQEEPVEGFRVTLVDEGDLYNWEVAIFGPPNTYYEGGYFKARLKFPIDYPYSPPAFRFLTKMWHPNIYETGDVCISILHPPSERWNPTQNVRTILLSVISLLNEPNTFSPANVDASVMYRKWKESKGKDREYTDIIRKQVLGTKVDAERDGVKVP 4mdk B 2.6095 BS01 U94 B 1 P48 T51 Y52 Y53 F58 L131 N132 W151 P42 T45 Y46 Y47 F52 L108 N109 W128 C93 C87 2.3.2.23,2.3.2.24 P49427 24316736 201 PSSQKALLLELKGLQEEPVEGFRVTLVDEGDLYNWEVAIFGPPNTYYEGGYFKARLKFPIDYPYSPPAFRFLTKMWHPNIYETGDVCISIWNPTQNVRTILLSVISLLNEPNTFSPANVDASVMYRKWKESKGKDREYTDIIRKQVLGTKVDAERDGVKVP 4mdk C 2.6095 BS01 U94 C 1 I45 P48 T51 Y52 Y53 F58 L131 N132 W151 I39 P42 T45 Y46 Y47 F52 L115 N116 W135 C93 C87 2.3.2.23,2.3.2.24 P49427 24316736 201 PSSQKALLLELKGLQEEPVEGFRVTLVDEGDLYNWEVAIFGPPNTYYEGGYFKARLKFPIDYPYSPPAFRFLTKMWHPNIYETGDVCISILHPPSERWNPTQNVRTILLSVISLLNEPNTFSPANVDASVMYRKWKESKGKDREYTDIIRKQVLGTKVDAERDGVKVP 4mdk D 2.6095 BS01 U94 D 1 I45 P48 T51 Y52 Y53 F58 L131 N132 W151 I39 P42 T45 Y46 Y47 F52 L104 N105 W124 C93 C87 2.3.2.23,2.3.2.24 P49427 24316736 201 PSSQKALLLELKGLQEEPVEGFRVTLVDEGDLYNWEVAIFGPPNTYYEGGYFKARLKFPIDYPYSPPAFRFLTKMWHPNIYETGDVCNPTQNVRTILLSVISLLNEPNTFSPANVDASVMYRKWKESKGKDREYTDIIRKQVLGTKVDAERDGVKVP 6nyo A 1.502 BS01 U94 A 1 P48 T51 L52 Y53 F58 L131 N132 W151 P44 T47 L48 Y49 F54 L127 N128 W147 2.3.2.23 Q712K3 31341161 301 QMTSSQKALMLELKSLQEEPVEGFRITLVDESDLYNWEVAIFGPPNTLYEGGYFKAHIKFPIDYPYSPPTFRFLTKMWHPNIYENGDVKISILHPPVDDPQSGELPSERWNPTQNVRTILLSVISLLNEPNTFSPANVDASVMFRKWRDSKGKDKEYAEIIRKQVSATKAEAEKDGVKVPTTLAEYCI 6nyo E 1.502 BS01 U94 A 1 G47 K48 G49 K50 ? P0CH08 31341161 301 SHMQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG