6mzq A 2.0 BS01 TZ0 A 1 L484 A512 K514 E531 M535 I545 E562 Y563 A564 N568 L630 A640 D641 L21 A46 K48 E65 M69 I79 E96 Y97 A98 N102 L161 A171 D172 D623 A625 R627 N628 D641 D154 A156 R158 N159 D172 2.7.10.1 0004672,0004713,0005007,0005524,0006468 ic50=3.9nM -logKd/Ki=8.41, IC50=3.9nM IC50=3.6nM P11362 30600916 801 ELPEDPRWELPRDRLVLGKPLGEGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYSYNPSEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSQE 6mzq B 2.0 BS01 TZ0 B 1 A512 K514 E531 Y563 A564 L630 D641 F642 A48 K50 E67 Y99 A100 L148 D159 F160 D623 A625 R627 N628 D641 D141 A143 R145 N146 D159 2.7.10.1 0004672,0004713,0005007,0005524,0006468 ic50=3.9nM IC50=3.6nM P11362 30600916 801 EYELPEDPRWELPRDRLVLGKPLGEGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALT 6mzw A 2.2 BS01 TZ0 A 1 L484 G485 C488 V492 A512 K514 E531 M535 I545 Y563 A564 L630 D641 F642 L21 G22 C25 V29 A49 K51 E68 M72 I82 Y100 A101 L165 D176 F177 D623 R627 N628 D641 D158 R162 N163 D176 2.7.10.1 0004672,0004713,0005007,0005524,0006468 -logKd/Ki=8.41, IC50=3.9nM IC50=3.6nM P11362 30600916 801 ELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYSYNPSPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQE 6mzw B 2.2 BS01 TZ0 B 1 L484 G485 A512 K514 M535 A564 L630 D641 F642 L22 G23 A43 K45 M66 A95 L146 D157 F158 D623 R627 N628 D641 D139 R143 N144 D157 2.7.10.1 0004672,0004713,0005007,0005524,0006468 IC50=3.6nM P11362 30600916 801 YELPEDPRWELPRDRLVLGKPLGQVVLAEAIGLDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTS 7d5o A 2.69 BS01 TZ0 A 1 Q275 A293 M314 V323 T338 Y340 M341 L393 D404 Q19 A33 M54 V63 T78 Y80 M81 L133 D144 2.7.10.2 0004672,0004713,0005524,0006468 P00523 601 KDAWEIPRESLRLEVKLGQEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 7d5o B 2.69 BS01 TZ0 B 1 V281 A293 K295 M314 Y340 M341 L393 A403 D404 F405 V21 A33 K35 M46 Y72 M73 L125 A135 D136 F137 2.7.10.2 0004672,0004713,0005524,0006468 P00523 601 DAWEIPRESLRLEVKLGQGEVWMGTWNGTTRVAIKTLKPTMEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTSTEPQYQPGENL