1ahg A 2.5 BS01 TYR A 1 D15 I17 L18 W140 R386 D11 I13 L14 W130 R374 W140 D222 A224 K258 W130 D211 A213 K246 2.6.1.1 0003824,0004069,0004838,0005737,0005829,0006520,0008483,0009058,0009094,0030170,0033585,0042802,0042803 P00509 7664122 501 MFENITAAPADPILGLADLFRADERPGKINLGIGLYYDETGKIPVLTSVKKAEQYLLENETTKLYLGIDGIPEFGRCTQELLFGKGSALINDKRARTAQTPGGSGALRVAADFLAKNTSVKRVWVSNPSWPNHKSVFNSAGLEVREYAYYDAENHTLDFDALINSLNEAQAGDVVLFHGCCHNPTGIDPTLEQWQTLAQLSVEKGWLPLFDFAYQGFARGLEEDAEGLRAFAAMHKELIVASSYSKNFGLYNERVGACTLVAADSETVDRAFSQMKAAIRANYSSPPAHGASVVATILSNDALRAIWEQELTDMRQRIQRMRQLFVNTLQEKGANRDFSFIIKQNGMFSFSGLTKEQVLRLREEFGVYAVASGRVNVAGMTPDNMAPLCEAIVAVL 1ahg B 2.5 BS01 TYR B 1 D15 I17 L18 W140 R386 D11 I13 L14 W130 R374 W140 D222 A224 K258 W130 D211 A213 K246 2.6.1.1 0003824,0004069,0004838,0005737,0005829,0006520,0008483,0009058,0009094,0030170,0033585,0042802,0042803 P00509 7664122 501 MFENITAAPADPILGLADLFRADERPGKINLGIGLYYDETGKIPVLTSVKKAEQYLLENETTKLYLGIDGIPEFGRCTQELLFGKGSALINDKRARTAQTPGGSGALRVAADFLAKNTSVKRVWVSNPSWPNHKSVFNSAGLEVREYAYYDAENHTLDFDALINSLNEAQAGDVVLFHGCCHNPTGIDPTLEQWQTLAQLSVEKGWLPLFDFAYQGFARGLEEDAEGLRAFAAMHKELIVASSYSKNFGLYNERVGACTLVAADSETVDRAFSQMKAAIRANYSSPPAHGASVVATILSNDALRAIWEQELTDMRQRIQRMRQLFVNTLQEKGANRDFSFIIKQNGMFSFSGLTKEQVLRLREEFGVYAVASGRVNVAGMTPDNMAPLCEAIVAVL 1fe1 A 3.8 BS01 TYR A 1 X81 X167 X81 X167 11217865 174 GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG 1fe1 J 3.8 BS01 TYR J 1 X81 X167 X81 X167 11217865 174 GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG 1j1u A 1.95 BS02 TYR A 1 Y32 G34 L65 H70 Y151 Q155 D158 Q173 Y32 G34 L65 H70 Y151 Q155 D158 Q173 6.1.1.1 0000166,0004812,0004831,0005524,0005737,0006412,0006418,0006437 Q57834 12754495 401 MDEFEMIKRNTSEIISEEELREVLKKDEKSAYIGFEPSGKIHLGHYLQIKKMIDLQNAGFDIIILLADLHAYLNQKGELDEIRKIGDYNKKVFEAMGLKAKYVYGSEFQLDKDYTLNVYRLALKTTLKRARRSMELIAREDENPKVAEVIYPIMQVNDIHYLGVDVAVGGMEQRKIHMLARELLPKKVVCIHNPVLTGLDGEGNFIAVDDSPEEIRAKIKKAYCPAGVVEGNPIMEIAKYFLEYPLTIKRPEKFGGDLTVNSYEELESLFKNKELHPMDLKNAVAEELIKILEPIRKRL 1s2k A 2.0 BS02 TYR A 1 N5 W6 N5 W6 Q53 E136 Q53 E129 3.4.23.32 0006508,0070007 P15369 14993599 1001 TVESNWGGAILIGSDFDTVSATANVPSASGGSSAAGTAWVGIDGDTCQTAILQTGFDWYGDGTYDAWYEWEVSITISEGDSIQMSVTATSDTSGSATLENLTTGQKVSKSFSNESSGSLCRTNAEFIIEDFEECNSNGSDCEFVPFASFSPAVEFTDCSVTSDGESVSLDDAQITQVIINNQDVTDCSVSGTTVSCSYV 1tya E 2.8 BS01 TYR E 1 Y34 G36 D38 L68 D78 Y169 Q173 D176 Q195 Y34 G36 D38 L68 D78 Y169 Q173 D176 Q195 6.1.1.1 0000166,0004812,0004831,0005524,0006418,0006437 P00952 320 MDLLAELQWRGLVNQTTDEDGLRKLLNEERVTLYCGFDPTADSLHIGHLAAILTMRRFQQAGHRPIALVGGATGLIGDPSGKKSERTLNAKETVEAWSARIKEQLGRFLDFEADGNPAKIKNNYDWIGPLDVITFLRDVGKHFSVNYMMAKESVQSRIETGISFTEFSYMMLQAYDFLRLYETEGCRLQIGGSDQWGNITAGLELIRKTKGRAFGLTIPLVTKADGTKFGKTESGTIWLDKEKTSPYEFYQFWINTDDRDVIRYLKYFTFLSKEEIEALEQELREAPEKRAAQKTLAEEVTKLVHGEEALRQAIRIS 1tyb E 2.5 BS01 TYR E 1 Y34 G36 D38 L68 T73 D78 Y169 Q173 D176 Q195 Y34 G36 D38 L68 T73 D78 Y169 Q173 D176 Q195 6.1.1.1 0000166,0004812,0004831,0005524,0006418,0006437 P00952 320 MDLLAELQWRGLVNQTTDEDGLRKLLNEERVTLYCGFDPTADSLHIGHLAGILTMRRFQQAGHRPIALVGGATGLIGDPSGKKSERTLNAKETVEAWSARIKEQLGRFLDFEADGNPAKIKNNYDWIGPLDVITFLRDVGKHFSVNYMMAKESVQSRIETGISFTEFSYMMLQAYDFLRLYETEGCRLQIGGSDQWGNITAGLELIRKTKGRAFGLTIPLVTKADGTKFGKTESGTIWLDKEKTSPYEFYQFWINTDDRDVIRYLKYFTFLSKEEIEALEQELREAPEKRAAQKTLAEEVTKLVHGEEALRQAIRIS 1tyd E 2.5 BS01 TYR E 1 Y34 G36 L68 D78 Y169 Q173 D176 Q195 Y34 G36 L68 D78 Y169 Q173 D176 Q195 6.1.1.1 0000166,0004812,0004831,0005524,0006418,0006437 P00952 2504923 320 MDLLAELQWRGLVNQTTDEDGLRKLLNEERVTLYCGFDPTADSLHIGHLASILTMRRFQQAGHRPIALVGGATGLIGDPSGKKSERTLNAKETVEAWSARIKEQLGRFLDFEADGNPAKIKNNYDWIGPLDVITFLRDVGKHFSVNYMMAKESVQSRIETGISFTEFSYMMLQAYDFLRLYETEGCRLQIGGSDQWGNITAGLELIRKTKGRAFGLTIPLVTKADGTKFGKTESGTIWLDKEKTSPYEFYQFWINTDDRDVIRYLKYFTFLSKEEIEALEQELREAPEKRAAQKTLAEEVTKLVHGEEALRQAIRIS 1wq4 A 2.0 BS01 TYR A 1 G39 L71 T76 D81 Y175 Q179 D182 Q201 G38 L70 T75 D80 Y174 Q178 D181 Q200 T43 H48 H51 K85 R89 Q179 D200 K235 K238 T239 T42 H47 H50 K84 R88 Q178 D199 K234 K237 T238 6.1.1.1 0000166,0004812,0004831,0005524,0006418,0006437 P0AGJ9 15671170 501 ASSNLIKQLQERGLVAQVTDEEALAERLAQGPIALVCGFDPTADSLHLGHLVPLLCLKRFQQAGHKPVALVGGATGLIGDPSFKAAERKLNTEETVQEWVDKIRKQVAPFLDFDCGENSAIAANNYDWFGNMNVLTFLRDIGKHFSVNQMINKEAVKQRLNREDQGISFTEFSYNLLQGYDFACLNKQYGVVLCIGGSDQWGNITSGIDLTRRLHQNQVFGLTVPLITKADGTKFGKTEGGAVWLDPKKTSPYKFYQFWINTADADVYRFLKFFTFMSIEEINALEEEDKNSGKAPRAQYVLAEQVTRLVHGEEGLQAAKR 1x8x A 2.0 BS01 TYR A 1 Y37 G39 D81 Y175 Q179 D182 Q201 Y37 G39 D81 Y175 Q179 D182 Q201 T43 H48 H51 K85 R89 Q179 D200 K235 K238 T239 T43 H48 H51 K85 R89 Q179 D200 K235 K238 T239 6.1.1.1 0000166,0004812,0004831,0005524,0006418,0006437 P0AGJ9 15663931 952 MASSNLIKQLQERGLVAQVTDEEALAERLAQGPIALYCGFDPTADSLHLGHLVPLLCLKRFQQAGHKPVALVGGATGLIGDPSFKAAERKLNTEETVQEWVDKIRKQVAPFLDFDCGENSAIAANNYDWFGNMNVLTFLRDIGKHFSVNQMINKEAVKQRLNREDQGISFTEFSYNLLQGYDFACLNKQYGVVLQIGGSDQWGNITSGIDLTRRLHQNQVFGLTVPLITKADGTKFGKTEGGAVWLDPKKTSPYKFYQFWINTADADVYRFLKFFTFMSIEEINALEEEDKNSGKAPRAQYVLAEQVTRLVHGEEGLQAAKR 1y42 X 1.95 BS01 TYR X 1 Y99 G101 D143 Y247 Q251 D254 Q273 Y61 G63 D105 Y198 Q202 D205 Q224 6.1.1.1 0000166,0004812,0004831,0005524,0006418,0006437 P12063 15694342 701 PKYTAKINEAEENWQARAEAIKKGKKQNTWDLFEERGYVKDTAGTKEHIAELMRTRRIGAYVGIDPTAPSLHVGHLLPLMPLFWMYLEGYKAFTLIGGSTAKIGDPTGDATMNMTKIHYQLKKLWENVDTQMRARGYEADWARKRGIVNNNHWWNKQPMLEVLRRVGHALRIGPMLSRDTVKNKMTQGDGVSFAEFTYPIMQGWDWFELFYQQGVQMQIGGSDQYGNIISGLEVVKAARESEPDPQERKYVTPKTALDECVGFTVPLLTDSSGAKFGKSAGNAIWLDPYQTSVFDFYGYFVRRSDQEVENLLKLFTFMPISEITKTMEEHIKDPSKRVAQHTLAREVVTLVHGKQEASAAEDQHRMMYTG 2amc A 2.7 BS01 TYR A 1 W149 H178 R204 Q218 E220 F258 F260 A314 G316 W65 H94 R120 Q134 E136 F174 F176 A230 G232 W149 H178 R204 Q218 V261 A314 W65 H94 R120 Q134 V177 A230 6.1.1.20 0000049,0000166,0004812,0004826,0005524,0005737,0006432,0043039 P27001 16338408 888 RVDVSLPGASLFSGGLHPITLMERELVEIFRALGYQAVEGPEVESEFFNFDALNIPEHHPARDMWDTFWLTGEGFRLEGPLGEEVEGRLLLRTHTSPMQVRYMVAHTPPFRIVVPGRVFRFEQTDATHEAVFHQLEGLVVGEGIAMAHLKGAIYELAQALFGPDSKVRFQPVYFPFVEPGAQFAVWWPEGGKWLELGGAGMVHPKVFQAVDAYRERLGLPPAYRGVTGFAFGLGVERLAMLRYGIPDIRYFFGGRLKFLEQFKGVL 2amc B 2.7 BS01 TYR B 1 M260 H261 L286 G315 G318 E334 A356 M260 H261 L286 G315 G318 E334 A356 6.1.1.20 0000049,0000287,0003723,0004812,0004826,0005524,0005737,0006412,0006432,0009328,0046872 Q5SGX1 16338408 999 MRVPFSWLKAYVPELESPEVLEERLAGLGFETDRIERVFPIPRGVVFARVLEAHPIPGTRLKRLVLDAGRTVEVVSGAENARKGIGVALALPGTELPGLGQKVGERVIQGVRSFGMALSPRELGVGEYGGGLLEFPEDALPPGTPLSEAWPEEVVLDLEVTPNRPDALGLLGLARDLHALGYALVEPEAALKAEALPLPFALKVEDPEGAPHFTLGYAFGLRVAPSPLWMQRALFAAGMRPINNVVDVTNYVMLERAQPMHAFDLRFVGEGIAVRRAREGERLKTLDGVERTLHPEDLVIAGWRGEESFPLGLAGVMGGAESEVREDTEAIALEVACFDPVSIRKTARRHGLRTEASHRFERGVDPLGQVPAQRRALSLLQALAGARVAEALLEAGSPKPPEAIPFRPEYANRLLGTSYPEAEQIAILKRLGCRVEGEGPTYRVTPPSHRLDLRLEEDLVEEVARIQGYETIPLALPAFFPAPDNRGVEAPYRKEQRLREVLSGLGFQEVYTYSFMDPEDARRFRLDPPRLLLLNPLAPEKAALRTHLFPGLVRVLKENLDLDRPERALLFEVGRVFREREETHLAGLLFGEGVGLPWAKERLSGYFLLKGYLEALFARLGLAFRVEAQAFPFLHPGVSGRVLVEGEEVGFLGALHPEIAQELELPPVHLFELRLPLPDKPLAFQDPSRHPAAFRDLAVVVPAPTPYGEVEALVREAAGPYLESLALFDLYQGPPLPEGHKSLAFHLRFRHPKRTLRDEEVEEAVSRVAEALRARGFGLRGLDTP 2bn2 A 2.8 BS02 TYR A 1 C10 C21 F22 G23 P24 C44 E47 N48 C10 C21 F22 G23 P24 C44 E47 N48 ? 0005185,0005576 P01180 2034668 99 AMSDLELRQCLPCGPGGKGRCFGPSICCGDELGCFVGTAEALRCQEENYLPSPCQSGQKPCGSGGRCAAAGICCNDESCVTEPEC 2bn2 C 2.8 BS02 TYR C 1 C10 F22 G23 C44 E47 C4 F16 G17 C38 E41 ? 0005185,0005576 P01180 2034668 99 LRQCLPCGPGGKGRCFGPSICCGDELGCFVGTAEALRCQEENYLPSPCQSGQKPCGSGGRCAAAGICCNDESCVTEPEC 2bn2 E 2.8 BS02 TYR E 1 C10 G23 P24 C44 E47 N48 C4 G17 P18 C38 E41 N42 ? 0005185,0005576 P01180 2034668 99 LRQCLPCGPGGKGRCFGPSICCGDELGCFVGTAEALRCQEENYLPSPCQSGQKPCGSGGRCAAAGICCNDESCVTEPEC 2bn2 G 2.8 BS02 TYR G 1 C10 G23 P24 C44 E47 C4 G17 P18 C38 E41 ? 0005185,0005576 P01180 2034668 99 LRQCLPCGPGGKGRCFGPSICCGDELGCFVGTAEALRCQEENYLPSPCQSGQKPCGSGGRCAAAGICCNDESCVTEPEC 2csm A 2.8 BS01 TYR A 1 I74 R75 R76 I74 R75 R76 R16 R157 K168 N194 E198 T242 E246 R16 R157 K168 N194 E198 T233 E237 5.4.99.5 0004106,0005515,0005634,0005737,0006571,0009073,0009094,0016853,0046417,0072545,0120284 -logKd/Ki=4.30, Ki=0.05mM P32178 8622937 300 MDFTKPETVLNLQNIRDELVRMEDSIIFKFIERSHFATCPSVYEANHPGLEIPNFKGSFLDWALSNLEIAHSRIRRFESPDETPFFPDKIQKSFLPSINYPQILAPYAPEVNYNDKIKKVYIEKIIPLISKRDGDDKNNFGSVATRDIECLQSLSRRIHFGKFVAEAKFQSDIPLYTKLIKSKDVEGIMKNITNSAVEEKILERLTKKAEVYGVRITPEYLVKIYKEIVIPITKEVEVEYLLRRL 2cyb A 1.8 BS01 TYR B 1 Y36 G38 L69 A71 H74 Y158 Q162 D165 Q180 Y35 G37 L68 A70 H73 Y157 Q161 D164 Q179 6.1.1.1 0000166,0004812,0004831,0005524,0005737,0006412,0006418,0006437 O29482 16325203 401 DITEKLRLITRNAEEVVTEEELRQLIETKEKPRAYVGYEPSGEIHLGHMMTVQKLMDLQEAGFEIIVLLADIHAYLNEKGTFEEIAEVADYNKKVFIALGLDESRAKFVLGSEYQLSRDYVLDVLKMARITTLNRARRSMDEVSRRKEDPMVSQMIYPLMQALDIAHLGVDLAVGGIDQRKIHMLARENLPRLGYSSPVCLHTPILVGLDGQKMSSSKGNYISVRDPPEEVERKIRKAYCPAGVVEENPILDIAKYHILPRFGKIVVERDAKFGGDVEYASFEELAEDFKSGQLHPLDLKIAVAKYLNMLLEDARKRLG 2cyb B 1.8 BS01 TYR B 2 Y36 G38 L69 A71 H74 Y158 Q162 D165 Q180 Y36 G38 L69 A71 H74 Y158 Q162 D165 Q180 6.1.1.1 0000166,0004812,0004831,0005524,0005737,0006412,0006418,0006437 O29482 16325203 501 MDITEKLRLITRNAEEVVTEEELRQLIETKEKPRAYVGYEPSGEIHLGHMMTVQKLMDLQEAGFEIIVLLADIHAYLNEKGTFEEIAEVADYNKKVFIALGLDESRAKFVLGSEYQLSRDYVLDVLKMARITTLNRARRSMDEVSRRKEDPMVSQMIYPLMQALDIAHLGVDLAVGGIDQRKIHMLARENLPRLGYSSPVCLHTPILVGLDGQKMSSSKGNYISVRDPPEEVERKIRKAYCPAGVVEENPILDIAKYHILPRFGKIVVERDAGDVEYASFEELAEDFKSGQLHPLDLKIAVAKYLNMLLEDARKRLG 2cyc A 2.2 BS01 TYR A 1 Y37 G39 H76 Y168 Q172 D175 Q190 Y37 G39 H76 Y168 Q172 D175 Q190 6.1.1.1 0000166,0004812,0004831,0005524,0005737,0006412,0006418,0006437 O58739 16325203 701 MDIEERINLVLKKPTEEVLTVENLRHLFEIGAPLQHYIGFEISGYIHLGTGLMAGAKIADFQKAGIKTRVFLADWHSWINDKLGGDLEVIQEVALKYFKVGMEKSIEVMGGDPKKVEFVLASEILEKGDYWQTVIDISKNVTLSRVMRSITIMGRQMGEAIDFAKLIYPMMQVADIFYQGVTIAHAGMDQRKAHVIAIEVAQKLRYHPIVHEGEKLKPVAVHHHLLLGLQEPPKWPIESEEEFKEIKAQMKMSKSKPYSAVFIHDSPEEIRQKLRKAFCPAREVRYNPVLDWVEYIIFREEPTEFTVHRPAKFGGDVTYTTFEELKRDFAEGKLHPLDLKNAVAEYLINLLEPIRRYFEKHPEPLELMRSV 2cyc B 2.2 BS01 TYR B 1 Y37 G39 A73 H76 Y168 Q172 D175 Q190 Y37 G39 A73 H76 Y168 Q172 D175 Q190 6.1.1.1 0000166,0004812,0004831,0005524,0005737,0006412,0006418,0006437 O58739 16325203 801 MDIEERINLVLKKPTEEVLTVENLRHLFEIGAPLQHYIGFEISGYIHLGTGLMAGAKIADFQKAGIKTRVFLADWHSWINDKLGGDLEVIQEVALKYFKVGMEKSIEVMGGDPKKVEFVLASEILEKGDYWQTVIDISKNVTLSRVMRSITIMGRQMGEAIDFAKLIYPMMQVADIFYQGVTIAHAGMDQRKAHVIAIEVAQKLRYHPIVHEGEKLKPVAVHHHLLLGLQEPPKWPIESEEEFKEIKAQMKMSKSKPYSAVFIHDSPEEIRQKLRKAFCPAREVRYNPVLDWVEYIIFREEPTEFTVHRPAKFGGDVTYTTFEELKRDFAEGKLHPLDLKNAVAEYLINLLEPIRRYFEKHPEPLELMRSV 2hnu A 2.0 BS02 TYR A 1 C10 G23 P24 C44 E47 C54 C4 G17 P18 C38 E41 C48 ? 0005185,0005576 P01175 17192588 2 VRTCLPCGPGGKGRCFGPSICCGDELGCFVGTAEALRCQEENYLPSPCQSGQKPCGSGGRCAAAGICCSPDGCHEDPACDP 2hnu B 2.0 BS02 TYR B 1 C10 G23 P24 C44 E47 C54 C4 G17 P18 C38 E41 C48 ? 0005185,0005576 P01175 17192588 2 VRTCLPCGPGGKGRCFGPSICCGDELGCFVGTAEALRCQEENYLPSPCQSGQKPCGSGGRCAAAGICCSPDGCHEDPACDP 2hnu C 2.0 BS02 TYR C 1 C10 C21 F22 G23 P24 C44 E47 C54 C4 C15 F16 G17 P18 C38 E41 C48 ? 0005185,0005576 P01175 17192588 2 VRTCLPCGPGGKGRCFGPSICCGDELGCFVGTAEALRCQEENYLPSPCQSGQKPCGSGGRCAAAGICCSPDGCHEDPACDP 2hnu D 2.0 BS02 TYR D 1 C10 G23 P24 C44 E47 C54 C4 G17 P18 C38 E41 C48 ? 0005185,0005576 P01175 17192588 2 VRTCLPCGPGGKGRCFGPSICCGDELGCFVGTAEALRCQEENYLPSPCQSGQKPCGSGGRCAAAGICCSPDGCHEDPACDP 2hnu E 2.0 BS02 TYR E 1 C10 F22 G23 P24 C44 E47 C4 F16 G17 P18 C38 E41 ? 0005185,0005576 P01175 17192588 2 VRTCLPCGPGGKGRCFGPSICCGDELGCFVGTAEALRCQEENYLPSPCQSGQKPCGSGGRCAAAGICCSPDGCHEDPACDP 2hnv A 2.5 BS02 TYR A 1 C10 C21 G23 P24 C44 E47 C54 C4 C15 G17 P18 C38 E41 C48 ? 0005185,0005576 P01175 17192588 2 VRTCLPCGPGGKGRCFGPSICCGDELGCFVGTAEALRCQEENYLPSPCQSGVKPCGSGGRCAAAGICCSPDGCHEDPACDP 2hnv B 2.5 BS02 TYR B 1 C10 C21 F22 G23 P24 C44 E47 N48 C4 C15 F16 G17 P18 C38 E41 N42 ? 0005185,0005576 P01175 17192588 2 VRTCLPCGPGGKGRCFGPSICCGDELGCFVGTAEALRCQEENYLPSPCQSGVKPCGSGGRCAAAGICCSPDGCHEDPACDP 2hnv C 2.5 BS02 TYR C 1 C10 C21 F22 G23 P24 C44 E47 C54 C4 C15 F16 G17 P18 C38 E41 C48 ? 0005185,0005576 P01175 17192588 2 VRTCLPCGPGGKGRCFGPSICCGDELGCFVGTAEALRCQEENYLPSPCQSGVKPCGSGGRCAAAGICCSPDGCHEDPACDP 2hnv D 2.5 BS02 TYR D 1 C10 C21 G23 P24 C44 E47 C54 C4 C15 G17 P18 C38 E41 C48 ? 0005185,0005576 P01175 17192588 2 VRTCLPCGPGGKGRCFGPSICCGDELGCFVGTAEALRCQEENYLPSPCQSGVKPCGSGGRCAAAGICCSPDGCHEDPACDP 2hnv E 2.5 BS02 TYR E 1 C10 C21 G23 P24 C44 E47 C54 C4 C15 G17 P18 C38 E41 C48 ? 0005185,0005576 P01175 17192588 2 VRTCLPCGPGGKGRCFGPSICCGDELGCFVGTAEALRCQEENYLPSPCQSGVKPCGSGGRCAAAGICCSPDGCHEDPACDP 2pv7 A 2.0 BS01 TYR A 1 S179 H200 F203 Q256 R297 Q301 Y306 S88 H109 F112 Q165 R206 Q210 Y215 1.3.1.12,5.4.99.5 0004665,0006571,0008977,0070403 P43902 20944228 401 GFKTINSDIHKIVIVGGYGKLGGLFARYLRASGYPISILDREDWAVAESILANADVVIVSVPINLTLETIERLKPYLTENMLLADLTSVKREPLAKMLEVHTGAVLGLHPMFGADIASMAKQVVVRCDGRFPERYEWLLEQIQIWGAKIYQTNATEHDHNMTYIQALRHFSTFANGLHLSKQPINLANLLALSSPIYRLELAMIGRLFAQDAELYADIIMNLAVIETLKQTYDEALTFFENNDRQGFIDAFHKVRDWFGDYSEQFLKESRQLLQQA 2pv7 B 2.0 BS01 TYR B 1 S179 H200 F203 Q256 R297 Q301 L305 Y306 S88 H109 F112 Q165 R206 Q210 L214 Y215 1.3.1.12,5.4.99.5 0004665,0006571,0008977,0070403 P43902 20944228 401 GFKTINSDIHKIVIVGGYGKLGGLFARYLRASGYPISILDREDWAVAESILANADVVIVSVPINLTLETIERLKPYLTENMLLADLTSVKREPLAKMLEVHTGAVLGLHPMFGADIASMAKQVVVRCDGRFPERYEWLLEQIQIWGAKIYQTNATEHDHNMTYIQALRHFSTFANGLHLSKQPINLANLLALSSPIYRLELAMIGRLFAQDAELYADIIMDKSENLAVIETLKQTYDEALTFFENNDRQGFIDAFHKVRDWFGDYSEQFLKESRQLLQQA 2qaa A 1.23 BS01 TYR A 1 H57 A192 E192A P192B G193 S195 G216 S217 H33 A136 E137 P138 G139 S141 G158 S159 H57 D102 G193 S195 S214 H33 D63 G139 S141 S156 3.4.21.81 0004252,0006508 P00777 18157955 1 ISGGDAIYSSTGRCSLGFNVRSGSTYYFLTAGHCTDGATTWWANSARTTVLGTTSGSSFPNNDYGIVRYTNTTIPKDGTVGGQDITSAANATVGMAVTRRGSTTGTHSGSVTALNATVNYGGGDVVYGMIRTNVCAEPGDSGGPLYSGTRAIGLTSGGSGNCSSGGTTFFQPVTEALSAYGVSVY 2qaa B 1.23 BS01 TYR B 1 H57 A192 E192A P192B G193 S195 G215 G216 S217 H33 A136 E137 P138 G139 S141 G157 G158 S159 H57 D102 G193 S195 S214 H33 D63 G139 S141 S156 3.4.21.81 0004252,0006508 P00777 18157955 1 ISGGDAIYSSTGRCSLGFNVRSGSTYYFLTAGHCTDGATTWWANSARTTVLGTTSGSSFPNNDYGIVRYTNTTIPKDGTVGGQDITSAANATVGMAVTRRGSTTGTHSGSVTALNATVNYGGGDVVYGMIRTNVCAEPGDSGGPLYSGTRAIGLTSGGSGNCSSGGTTFFQPVTEALSAYGVSVY 2vby A 2.8 BS01 TYR A 1 D82 V100 A101 G102 S105 Y106 D79 V97 A98 G99 S102 Y103 ? 0003677,0005829,0016597,0043200,0043565,0051260 P96896 17962306 1153 ALDDIDRILVRELAADGRATLSELATRAGLSVSAVQSRVRRLESRGVVQGYSARINPEAVGHLLSAFVAITPLDPSQPDDAPARLEHIEEVESCYSVAGEESYVLLVRVASARALEDLLQRIRTTANVRTRSTIILNTFYSDRQHIP 2whz A 1.75 BS02 TYR A 1 N111 N112 F130 L202 H231 N111 N112 F130 L202 H231 H142 E143 H146 Y157 E166 D226 H231 H142 E143 H146 Y157 E166 D226 H231 3.4.24.27 0004222,0006508 P00800 1002 ITGTSTVGVGRGVLGDQKNINTTYSTYYYLQDNTRGNGIFTYDAKYRTTLPGSLWADADNQFFASYDAPAVDAHYYAGVTYDYYKNVHNRLSYDGNNAAIRSSVHYSQGYNNAFWNGSQMVYGDGDGQTFIPLSGGIDVVAHELTHAVTDYTAGLIYQNESGAINEAISDIFGTLVEFYANKNPDWEIGEDVYTPGISGDSLRSMSDPAKYGDPDHYSKRYTGTQDNGGVHINSGIINKAAYLISQGGTHYGVSVVGIGRDKLGKIFYRALTQYLTPTSNFSQLRAAAVQSATDLYGSTSQEVASVKQAFDAVGVK 2xii A 1.8 BS01 TYR A 1 A387 R399 D403 V405 A353 R365 D369 V371 3.2.1.51 0004560,0005764,0005975,0006004,0016139,0016787 Q8A3I4 20665773 1001 EIPLKYGATNEGKRQDPAMQKFRDNRLGAFIHWGLYAIPGGEWNGKVYGGAAEWLKSWAKVPADEWLKLMDQWNPTKFDAKKWAKMAKEMGTKYVKITTKHHEGFCLWPSKYTKYTVANTPYKRDILGELVKAYNDEGIDVHFYFSVMDWSNPDYRYDIKSKEDSIAFSRFLEFTDNQLKELATRYPTVKDFWFDGTWDASVKKNGWWTAHAEQMLKELVPGVAINSRLRADDKGKRHFDSNGRLMGDYESGYERRLPDPVKDLKVTQWDWEACMTIPENQWGYHKDWSLSYVKTPIEVIDRIVHAVSMGGNMVVNFGPQADGDFRPEEKAMATAIGKWMNRYGKAVYACDYAGFEKQDWGYYTRGKNDEVYMVVFNQPYSERLIVKTPKGITVEKATLLTTGEDITVVETTRNEYNVSVPKKNPGEPYVIQLKVRAA 2xii B 1.8 BS01 TYR B 1 A387 R399 D403 V405 A471 A353 R365 D369 V371 A437 3.2.1.51 0004560,0005764,0005975,0006004,0016139,0016787 Q8A3I4 20665773 1001 EIPLKYGATNEGKRQDPAMQKFRDNRLGAFIHWGLYAIPGGEWNGKVYGGAAEWLKSWAKVPADEWLKLMDQWNPTKFDAKKWAKMAKEMGTKYVKITTKHHEGFCLWPSKYTKYTVANTPYKRDILGELVKAYNDEGIDVHFYFSVMDWSNPDYRYDIKSKEDSIAFSRFLEFTDNQLKELATRYPTVKDFWFDGTWDASVKKNGWWTAHAEQMLKELVPGVAINSRLRADDKGKRHFDSNGRLMGDYESGYERRLPDPVKDLKVTQWDWEACMTIPENQWGYHKDWSLSYVKTPIEVIDRIVHAVSMGGNMVVNFGPQADGDFRPEEKAMATAIGKWMNRYGKAVYACDYAGFEKQDWGYYTRGKNDEVYMVVFNQPYSERLIVKTPKGITVEKATLLTTGEDITVVETTRNEYNVSVPKKNPGEPYVIQLKVRAAK 2ypp A 2.3 BS01 TYR A 1 F91 R171 N175 F89 R169 N173 2.5.1.54 0003849,0005515,0005829,0005886,0008652,0009073,0009274,0009423,0016740,0030145,0046872,0051260 Kd=39uM -logKd/Ki=4.41, Kd=39uM O53512 23274137 800 MNWTVDIPIDPSLPPLPTDLRTRLDAALAKPAAQQPTWPADQALAMRTVLESVPPVTVPSEIVRLQEQLAQVAKGEAFLLQGGDCAETFMDNTEPHIRGNVRALLQMAVVLTYGASMPVVKVARIAGQYAKPRSADIDALGLRSYRGDMINGFAPDAAAREHDPSRLVRAYANASAAMNLVRALTSSGLASLHLVHDWNREFVRTSPAGARYEALATEIDRGLRFMSACGVADRNLQTAEIYASHEALVLDYERAMLRLSDGDDGEPQLFDLSAHTVWIGERTRQIDGAHIAFAQVIANPVGVKLGPNMTPELAVEYVERLDPHNKPGRLTLVSRMGNHKVRDLLPPIVEKVQATGHQVIWQCDPMHGNTHESSTGFKTRHFDRIVDEVQGFFEVHRALGTHPGGIHVEITGENVTECLGGAQDISETDLAGRYETACDPRLNTQQSLELAFLVAEMLRD 2ypp A 2.3 BS03 TYR B 1 V55 Y173 A174 V53 Y171 A172 2.5.1.54 0003849,0005515,0005829,0005886,0008652,0009073,0009274,0009423,0016740,0030145,0046872,0051260 Kd=39uM -logKd/Ki=4.41, Kd=39uM O53512 23274137 800 MNWTVDIPIDPSLPPLPTDLRTRLDAALAKPAAQQPTWPADQALAMRTVLESVPPVTVPSEIVRLQEQLAQVAKGEAFLLQGGDCAETFMDNTEPHIRGNVRALLQMAVVLTYGASMPVVKVARIAGQYAKPRSADIDALGLRSYRGDMINGFAPDAAAREHDPSRLVRAYANASAAMNLVRALTSSGLASLHLVHDWNREFVRTSPAGARYEALATEIDRGLRFMSACGVADRNLQTAEIYASHEALVLDYERAMLRLSDGDDGEPQLFDLSAHTVWIGERTRQIDGAHIAFAQVIANPVGVKLGPNMTPELAVEYVERLDPHNKPGRLTLVSRMGNHKVRDLLPPIVEKVQATGHQVIWQCDPMHGNTHESSTGFKTRHFDRIVDEVQGFFEVHRALGTHPGGIHVEITGENVTECLGGAQDISETDLAGRYETACDPRLNTQQSLELAFLVAEMLRD 2ypp B 2.3 BS01 TYR A 1 V55 Y173 A174 V52 Y170 A171 2.5.1.54 0003849,0005515,0005829,0005886,0008652,0009073,0009274,0009423,0016740,0030145,0046872,0051260 Kd=39uM -logKd/Ki=4.41, Kd=39uM O53512 23274137 800 MNWTVDIPIPSLPPLPTDLRTRLDAALAKPAAQQPTWPADQALAMRTVLESVPPVTVPSEIVRLQEQLAQVAKGEAFLLQGGDCAETFMDNTEPHIRGNVRALLQMAVVLTYGASMPVVKVARIAGQYAKPRSADIDALGLRSYRGDMINGFAPDAAAREHDPSRLVRAYANASAAMNLVRALTSSGLASLHLVHDWNREFVRTSPAGARYEALATEIDRGLRFMSACGVADRNLQTAEIYASHEALVLDYERAMLRLSDGDDGEPQLFDLSAHTVWIGERTRQIDGAHIAFAQVIANPVGVKLGPNMTPELAVEYVERLDPHNKPGRLTLVSRMGNHKVRDLLPPIVEKVQATGHQVIWQCDPMHGNTHESSTGFKTRHFDRIVDEVQGFFEVHRALGTHPGGIHVEITGENVTECLGGAQDISETDLAGRYETACDPRLNTQQSLELAFLVAEMLRD 2ypp B 2.3 BS03 TYR B 1 F91 R171 A174 N175 F88 R168 A171 N172 2.5.1.54 0003849,0005515,0005829,0005886,0008652,0009073,0009274,0009423,0016740,0030145,0046872,0051260 Kd=39uM -logKd/Ki=4.41, Kd=39uM O53512 23274137 800 MNWTVDIPIPSLPPLPTDLRTRLDAALAKPAAQQPTWPADQALAMRTVLESVPPVTVPSEIVRLQEQLAQVAKGEAFLLQGGDCAETFMDNTEPHIRGNVRALLQMAVVLTYGASMPVVKVARIAGQYAKPRSADIDALGLRSYRGDMINGFAPDAAAREHDPSRLVRAYANASAAMNLVRALTSSGLASLHLVHDWNREFVRTSPAGARYEALATEIDRGLRFMSACGVADRNLQTAEIYASHEALVLDYERAMLRLSDGDDGEPQLFDLSAHTVWIGERTRQIDGAHIAFAQVIANPVGVKLGPNMTPELAVEYVERLDPHNKPGRLTLVSRMGNHKVRDLLPPIVEKVQATGHQVIWQCDPMHGNTHESSTGFKTRHFDRIVDEVQGFFEVHRALGTHPGGIHVEITGENVTECLGGAQDISETDLAGRYETACDPRLNTQQSLELAFLVAEMLRD 2ypp B 2.3 BS04 TYR B 2 L15 P16 L18 R23 E53 R256 L12 P13 L15 R20 E50 R253 2.5.1.54 0003849,0005515,0005829,0005886,0008652,0009073,0009274,0009423,0016740,0030145,0046872,0051260 Kd=39uM -logKd/Ki=4.41, Kd=39uM O53512 23274137 801 MNWTVDIPIPSLPPLPTDLRTRLDAALAKPAAQQPTWPADQALAMRTVLESVPPVTVPSEIVRLQEQLAQVAKGEAFLLQGGDCAETFMDNTEPHIRGNVRALLQMAVVLTYGASMPVVKVARIAGQYAKPRSADIDALGLRSYRGDMINGFAPDAAAREHDPSRLVRAYANASAAMNLVRALTSSGLASLHLVHDWNREFVRTSPAGARYEALATEIDRGLRFMSACGVADRNLQTAEIYASHEALVLDYERAMLRLSDGDDGEPQLFDLSAHTVWIGERTRQIDGAHIAFAQVIANPVGVKLGPNMTPELAVEYVERLDPHNKPGRLTLVSRMGNHKVRDLLPPIVEKVQATGHQVIWQCDPMHGNTHESSTGFKTRHFDRIVDEVQGFFEVHRALGTHPGGIHVEITGENVTECLGGAQDISETDLAGRYETACDPRLNTQQSLELAFLVAEMLRD 2ypq A 2.76 BS01 TYR A 1 F91 R171 N175 F89 R169 N173 2.5.1.54 0003849,0005515,0005829,0005886,0008652,0009073,0009274,0009423,0016740,0030145,0046872,0051260 O53512 23274137 1465 MNWTVDIPIDPSLPPLPTDLRTRLDAALAKPAAQQPTWPADQALAMRTVLESVPPVTVPSEIVRLQEQLAQVAKGEAFLLQGGDCAETFMDNTEPHIRGNVRALLQMAVVLTYGASMPVVKVARIAGQYAKPRSADIDALGLRSYRGDMINGFAPDAAAREHDPSRLVRAYANASAAMNLVRALTSSGLASLHLVHDWNREFVRTSPAGARYEALATEIDRGLRFMSACGVADRNLQTAEIYASHEALVLDYERAMLRLSDGDDGEPQLFDLSAHTVWIGERTRQIDGAHIAFAQVIANPVGVKLGPNMTPELAVEYVERLDPHNKPGRLTLVSRMGNHKVRDLLPPIVEKVQATGHQVIWQCDPMHGNTHESSTGFKTRHFDRIVDEVQGFFEVHRALGTHPGGIHVEITGENVTECLGGAQDISETDLAGRYETACDPRLNTQQSLELAFLVAEMLRD 2ypq A 2.76 BS05 TYR B 1 Y173 A174 Y171 A172 2.5.1.54 0003849,0005515,0005829,0005886,0008652,0009073,0009274,0009423,0016740,0030145,0046872,0051260 O53512 23274137 1465 MNWTVDIPIDPSLPPLPTDLRTRLDAALAKPAAQQPTWPADQALAMRTVLESVPPVTVPSEIVRLQEQLAQVAKGEAFLLQGGDCAETFMDNTEPHIRGNVRALLQMAVVLTYGASMPVVKVARIAGQYAKPRSADIDALGLRSYRGDMINGFAPDAAAREHDPSRLVRAYANASAAMNLVRALTSSGLASLHLVHDWNREFVRTSPAGARYEALATEIDRGLRFMSACGVADRNLQTAEIYASHEALVLDYERAMLRLSDGDDGEPQLFDLSAHTVWIGERTRQIDGAHIAFAQVIANPVGVKLGPNMTPELAVEYVERLDPHNKPGRLTLVSRMGNHKVRDLLPPIVEKVQATGHQVIWQCDPMHGNTHESSTGFKTRHFDRIVDEVQGFFEVHRALGTHPGGIHVEITGENVTECLGGAQDISETDLAGRYETACDPRLNTQQSLELAFLVAEMLRD 2ypq B 2.76 BS01 TYR B 1 F91 R171 N175 F86 R166 N170 2.5.1.54 0003849,0005515,0005829,0005886,0008652,0009073,0009274,0009423,0016740,0030145,0046872,0051260 O53512 23274137 1465 MNWTVDIPILPPLPTDLRTRLDAALAKPAAQQPTWPADQALAMRTVLESVPPVTVPSEIVRLQEQLAQVAKGEAFLLQGGDCAETFMDNTEPHIRGNVRALLQMAVVLTYGASMPVVKVARIAGQYAKPRSADIDALGLRSYRGDMINGFAPDAAAREHDPSRLVRAYANASAAMNLVRALTSSGLASLHLVHDWNREFVRTSPAGARYEALATEIDRGLRFMSACGVADRNLQTAEIYASHEALVLDYERAMLRLSDGDDGEPQLFDLSAHTVWIGERTRQIDGAHIAFAQVIANPVGVKLGPNMTPELAVEYVERLDPHNKPGRLTLVSRMGNHKVRDLLPPIVEKVQATGHQVIWQCDPMHGNTHESSTGFKTRHFDRIVDEVQGFFEVHRALGTHPGGIHVEITGENVTECLGGAQDISETDLAGRYETACDPRLNTQQSLELAFLVAEMLRD 2ypq B 2.76 BS02 TYR B 2 P16 L18 R23 E53 R256 P11 L13 R18 E48 R251 2.5.1.54 0003849,0005515,0005829,0005886,0008652,0009073,0009274,0009423,0016740,0030145,0046872,0051260 O53512 23274137 1466 MNWTVDIPILPPLPTDLRTRLDAALAKPAAQQPTWPADQALAMRTVLESVPPVTVPSEIVRLQEQLAQVAKGEAFLLQGGDCAETFMDNTEPHIRGNVRALLQMAVVLTYGASMPVVKVARIAGQYAKPRSADIDALGLRSYRGDMINGFAPDAAAREHDPSRLVRAYANASAAMNLVRALTSSGLASLHLVHDWNREFVRTSPAGARYEALATEIDRGLRFMSACGVADRNLQTAEIYASHEALVLDYERAMLRLSDGDDGEPQLFDLSAHTVWIGERTRQIDGAHIAFAQVIANPVGVKLGPNMTPELAVEYVERLDPHNKPGRLTLVSRMGNHKVRDLLPPIVEKVQATGHQVIWQCDPMHGNTHESSTGFKTRHFDRIVDEVQGFFEVHRALGTHPGGIHVEITGENVTECLGGAQDISETDLAGRYETACDPRLNTQQSLELAFLVAEMLRD 3b37 A 1.7 BS02 TYR A 1 Q119 E121 M260 A262 M263 E264 H297 E298 H301 E320 Y376 Y381 Q115 E117 M256 A258 M259 E260 H293 E294 H297 E316 Y372 Y377 E264 H297 E298 H301 E320 N373 Y381 E260 H293 E294 H297 E316 N369 Y377 3.4.11.2 0004177,0005515,0005886,0006508,0008237,0008270,0042802,0046872 P04825 18416562 900 PQAKYRHDYRAPDYQITDIDLTFDLDAQKTVVTAVSQAVRHGASDAPLRLNGEDLKLVSVHINDEPWTAWKEEEGALVISNLPERFTLKIINEISPAANTALEGLYQSGDALCTQCEAEGFRHITYYLDRPDVLARFTTKIIADKIKYPFLLSNGNRVAQGELENGRHWVQWQDPFPKPCYLFALVAGDFDVLRDTFTTRSGREVALELYVDRGNLDRAPWAMTSLKNSMKWDEERFGLEYDLDIYMIVAVDFFNMGAMENKGLNIFNSKYVLARTDTATDKDYLDIERVIGHEYFHNWTGNRVTCRDWFQLSLKEGLTVFRDQEFSSDLGSRAVNRINNVRTMRGLQFAEDASPMAHPIRPDMVIEMNNFYTLTVYEKGAEVIRMIHTLLGEENFQKGMQLYFERHDGSAATCDDFVQAMEDASNVDLSHFRRWYSQSGTPIVTVKDDYNPETEQYTLTISQRTPATPDQAEKQPLHIPFAIELYDNEGKVIPLQKGGHPVNSVLNVTQAEQTFVFDNVYFQPVPALLCEFSAPVKLEYKWSDQQLTFLMRHARNDFSRWDAAQSLLATYIKLNVARHQQGQPLSLPVHVADAFRAVLLDEKIDPALAAEILTLPSVNEMAELFDIIDPIAIAEVREALTRTLATELADELLAIYNANYQSEYRVEHEDIAKRTLRNACLRFLAFGETHLADVLVSKQFHEANNMTDALAALSAAVAAQLPCRDALMQEYDDKWHQNGLVMDKWFILQATSPAANVLETVRGLLQHRSFTMSNPNRIRSLIGAFAGSNPAAFHAEDGSGYLFLVEMLTDLNSRNPQVASRLIEPLIRLKRYDAKRQEKMRAALEQLKGLENLSGDLYEKITKALA 3cpa A 2.0 BS02 TYR A 1 N144 R145 I243 Y248 A250 G253 N144 R145 I243 Y248 A250 G253 H69 E72 R127 H196 E270 H69 E72 R127 H196 E270 3.4.17.1 0004181,0006508,0008270 P00730 3463986 502 ARSTNTFNYATYHTLDEIYDFMDLLVAQHPELVSKLQIGRSYEGRPIYVLKFSTGGSNRPAIWIDLGIHSREWITQATGVWFAKKFTENYGQNPSFTAILDSMDIFLEIVTNPNGFAFTHSENRLWRKTRSVTSSSLCVGVDANRNWDAGFGKAGASSSPCSETYHGKYANSEVEVKSIVDFVKNHGNFKAFLSIHSYSQLLLYPYGYTTQSIPDKTELNQVAKSAVAALKSLYGTSYKYGSIITTIYQASGGSIDWSYNQGIKYSFTFELRDTGRYGFLLPASQIIPTAQETWLGVLTIMEHTVNN 3ggg A 2.21 BS02 TYR C 1 G242 G243 G217 G218 ? 0000166,0004665,0006571,0008977,0016491,0070403 O67636 19279014 5959 KSLSMQNVLIVGVGFMGGSFAKSLRRSGFKGKIYGYDINPESISKAVDLGIIDEGTTSIAKVEDFSPDFVMLSSPVRTFREIAKKLSYILSEDATVTDQGSVKGKLVYDLENILGKRFVGGHPIAGTEKSGVEYSLDNLYEGKKVILTPTKKTDKKRLKLVKRVWEDVGGVVEYMSPELHDYVFGVVSHLPHAVAFALVDTLIHMSTPEVDLFKYPGGGFKDFTRIAKSDPIMWRDIFLENKENVMKAIEGFEKSLNHLKELIVREAEEELVEYLKEVKIKRMEI 3ggg B 2.21 BS02 TYR B 1 S126 H147 G151 T152 R250 S109 H130 G134 T135 R233 ? 0000166,0004665,0006571,0008977,0016491,0070403 O67636 19279014 6959 MKNIIKILKSLSMQNVLIVGVGFMGGSFAKSLRRSGFKGKIYGYDINPESISKAVDLGIIDEGTTSIAKVEDFSPDFVMLSSPVRTFREIAKKLSYILSEDATVTDQGSVKGKLVYDLENILGKRFVGGHPIAGTEKSGVEYSLDNLYEGKKVILTPTKKTDKKRLKLVKRVWEDVGGVVEYMSPELHDYVFGVVSHLPHAVAFALVDTLIHMSTPEVDLFKYPGGGFKDFTRIAKSDPIMWRDIFLENKENVMKAIEGFEKSLNHLKELIVREAEEELVEYLKEVKIKR 3ggg C 2.21 BS02 TYR C 1 S126 H147 T152 R250 I251 S102 H123 T128 R226 I227 ? 0000166,0004665,0006571,0008977,0016491,0070403 O67636 19279014 5959 LKSLSMQNVLIVGVGFMGGSFAKSLRRSGFKGKIYGYDINPESISKAVDLGIIDEGTTSIAKVEDFSPDFVMLSSPVRTFREIAKKLSYILSEDATVTDQGSVKGKLVYDLENILGKRFVGGHPIAGTEKSGVEYSLDNLYEGKKVILTPTKKTDKKRLKLVKRVWEDVGGVVEYMSPELHDYVFGVVSHLPHAVAFALVDTLIHMSTPEVDLFKYPGGGFKDFTRIAKSDPIMWRDIFLENKENVMKAIEGFEKSLNHLKELIVREAEEELVEYLKEVKI 3ggg D 2.21 BS02 TYR B 1 G242 G243 G225 G226 ? 0000166,0004665,0006571,0008977,0016491,0070403 O67636 19279014 6959 MKNIIKILKSLSMQNVLIVGVGFMGGSFAKSLRRSGFKGKIYGYDINPESISKAVDLGIIDEGTTSIAKVEDFSPDFVMLSSPVRTFREIAKKLSYILSEDATVTDQGSVKGKLVYDLENILGKRFVGGHPIAGTEKSGVEYSLDNLYEGKKVILTPTKKTDKKRLKLVKRVWEDVGGVVEYMSPELHDYVFGVVSHLPHAVAFALVDTLIHMSTPEVDLFKYPGGGFKDFTRIAKSDPIMWRDIFLENKENVMKAIEGFEKSLNHLKELIVREAEEELVEYLKEVKIKRMEI 3jw7 A 1.8 BS02 TYR A 1 F53 I54 K161 D240 K264 C292 A294 E295 F53 I54 K161 D240 K264 C292 A294 E295 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 5.1.1.- 0000287,0006518,0009063,0016853,0016854,0016855,0046872 Q834W6 22392983 356 MKIKQVHVRASKIKLKETFTIALGTIESADSAIVEIETEEGLVGYGEGGPGIFITGETLAGTLETIELFGQAIIGLNPFNIEKIHEVMDKISAFAPAAKAAIDIACYDLMGQKAQLPLYQLLGGYDNQVITDITLGIDEPNVMAQKAVEKVKLGFDTLKIKVGTGIEADIARVKAIREAVGFDIKLRLDANQAWTPKDAVKAIQALADYQIELVEQPVKRRDLEGLKYVTSQVNTTIMADESCFDAQDALELVKKGTVDVINIKLMKCGGIHEALKINQICETAGIECMIGCMAEETTIGITAAAHLAAAQKNITRADLDATFGLETAPVTGGVSLEAKPLLELGEAAGLGIS 3jw7 B 1.8 BS02 TYR B 1 F53 I54 K161 D240 K264 C292 A294 E295 F53 I54 K161 D240 K264 C292 A294 E295 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 5.1.1.- 0000287,0006518,0009063,0016853,0016854,0016855,0046872 Q834W6 22392983 356 MKIKQVHVRASKIKLKETFTIALGTIESADSAIVEIETEEGLVGYGEGGPGIFITGETLAGTLETIELFGQAIIGLNPFNIEKIHEVMDKISAFAPAAKAAIDIACYDLMGQKAQLPLYQLLGGYDNQVITDITLGIDEPNVMAQKAVEKVKLGFDTLKIKVGTGIEADIARVKAIREAVGFDIKLRLDANQAWTPKDAVKAIQALADYQIELVEQPVKRRDLEGLKYVTSQVNTTIMADESCFDAQDALELVKKGTVDVINIKLMKCGGIHEALKINQICETAGIECMIGCMAEETTIGITAAAHLAAAQKNITRADLDATFGLETAPVTGGVSLEAKPLLELGEAAGLGIS 3jw7 C 1.8 BS02 TYR C 1 I21 F53 K159 K161 D240 K264 M293 A294 E295 I21 F53 K159 K161 D240 K264 M293 A294 E295 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 5.1.1.- 0000287,0006518,0009063,0016853,0016854,0016855,0046872 Q834W6 22392983 356 MKIKQVHVRASKIKLKETFTIALGTIESADSAIVEIETEEGLVGYGEGGPGIFITGETLAGTLETIELFGQAIIGLNPFNIEKIHEVMDKISAFAPAAKAAIDIACYDLMGQKAQLPLYQLLGGYDNQVITDITLGIDEPNVMAQKAVEKVKLGFDTLKIKVGTGIEADIARVKAIREAVGFDIKLRLDANQAWTPKDAVKAIQALADYQIELVEQPVKRRDLEGLKYVTSQVNTTIMADESCFDAQDALELVKKGTVDVINIKLMKCGGIHEALKINQICETAGIECMIGCMAEETTIGITAAAHLAAAQKNITRADLDATFGLETAPVTGGVSLEAKPLLELGEAAGLGIS 3jw7 D 1.8 BS02 TYR D 1 F53 K161 D240 K264 C292 M293 A294 E295 F53 K161 D240 K264 C292 M293 A294 E295 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 5.1.1.- 0000287,0006518,0009063,0016853,0016854,0016855,0046872 Q834W6 22392983 356 MKIKQVHVRASKIKLKETFTIALGTIESADSAIVEIETEEGLVGYGEGGPGIFITGETLAGTLETIELFGQAIIGLNPFNIEKIHEVMDKISAFAPAAKAAIDIACYDLMGQKAQLPLYQLLGGYDNQVITDITLGIDEPNVMAQKAVEKVKLGFDTLKIKVGTGIEADIARVKAIREAVGFDIKLRLDANQAWTPKDAVKAIQALADYQIELVEQPVKRRDLEGLKYVTSQVNTTIMADESCFDAQDALELVKKGTVDVINIKLMKCGGIHEALKINQICETAGIECMIGCMAEETTIGITAAAHLAAAQKNITRADLDATFGLETAPVTGGVSLEAKPLLELGEAAGLGIS 3jw7 E 1.8 BS02 TYR E 1 F53 K161 D240 K264 C292 A294 E295 F53 K161 D240 K264 C292 A294 E295 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 5.1.1.- 0000287,0006518,0009063,0016853,0016854,0016855,0046872 Q834W6 22392983 356 MKIKQVHVRASKIKLKETFTIALGTIESADSAIVEIETEEGLVGYGEGGPGIFITGETLAGTLETIELFGQAIIGLNPFNIEKIHEVMDKISAFAPAAKAAIDIACYDLMGQKAQLPLYQLLGGYDNQVITDITLGIDEPNVMAQKAVEKVKLGFDTLKIKVGTGIEADIARVKAIREAVGFDIKLRLDANQAWTPKDAVKAIQALADYQIELVEQPVKRRDLEGLKYVTSQVNTTIMADESCFDAQDALELVKKGTVDVINIKLMKCGGIHEALKINQICETAGIECMIGCMAEETTIGITAAAHLAAAQKNITRADLDATFGLETAPVTGGVSLEAKPLLELGEAAGLGIS 3jw7 F 1.8 BS02 TYR F 1 I21 F53 K161 D240 K264 C292 M293 A294 E295 I21 F53 K161 D240 K264 C292 M293 A294 E295 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 5.1.1.- 0000287,0006518,0009063,0016853,0016854,0016855,0046872 Q834W6 22392983 356 MKIKQVHVRASKIKLKETFTIALGTIESADSAIVEIETEEGLVGYGEGGPGIFITGETLAGTLETIELFGQAIIGLNPFNIEKIHEVMDKISAFAPAAKAAIDIACYDLMGQKAQLPLYQLLGGYDNQVITDITLGIDEPNVMAQKAVEKVKLGFDTLKIKVGTGIEADIARVKAIREAVGFDIKLRLDANQAWTPKDAVKAIQALADYQIELVEQPVKRRDLEGLKYVTSQVNTTIMADESCFDAQDALELVKKGTVDVINIKLMKCGGIHEALKINQICETAGIECMIGCMAEETTIGITAAAHLAAAQKNITRADLDATFGLETAPVTGGVSLEAKPLLELGEAAGLGIS 3jw7 G 1.8 BS02 TYR G 1 I21 F53 K159 K161 D240 K264 M293 A294 E295 I21 F53 K159 K161 D240 K264 M293 A294 E295 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 5.1.1.- 0000287,0006518,0009063,0016853,0016854,0016855,0046872 Q834W6 22392983 356 MKIKQVHVRASKIKLKETFTIALGTIESADSAIVEIETEEGLVGYGEGGPGIFITGETLAGTLETIELFGQAIIGLNPFNIEKIHEVMDKISAFAPAAKAAIDIACYDLMGQKAQLPLYQLLGGYDNQVITDITLGIDEPNVMAQKAVEKVKLGFDTLKIKVGTGIEADIARVKAIREAVGFDIKLRLDANQAWTPKDAVKAIQALADYQIELVEQPVKRRDLEGLKYVTSQVNTTIMADESCFDAQDALELVKKGTVDVINIKLMKCGGIHEALKINQICETAGIECMIGCMAEETTIGITAAAHLAAAQKNITRADLDATFGLETAPVTGGVSLEAKPLLELGEAAGLGIS 3jw7 H 1.8 BS02 TYR H 1 F53 K159 K161 D240 K264 C292 A294 E295 F53 K159 K161 D240 K264 C292 A294 E295 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 5.1.1.- 0000287,0006518,0009063,0016853,0016854,0016855,0046872 Q834W6 22392983 356 MKIKQVHVRASKIKLKETFTIALGTIESADSAIVEIETEEGLVGYGEGGPGIFITGETLAGTLETIELFGQAIIGLNPFNIEKIHEVMDKISAFAPAAKAAIDIACYDLMGQKAQLPLYQLLGGYDNQVITDITLGIDEPNVMAQKAVEKVKLGFDTLKIKVGTGIEADIARVKAIREAVGFDIKLRLDANQAWTPKDAVKAIQALADYQIELVEQPVKRRDLEGLKYVTSQVNTTIMADESCFDAQDALELVKKGTVDVINIKLMKCGGIHEALKINQICETAGIECMIGCMAEETTIGITAAAHLAAAQKNITRADLDATFGLETAPVTGGVSLEAKPLLELGEAAGLGIS 3jzu A 2.0 BS02 TYR A 1 I21 I26 F53 K161 N191 D240 K264 M293 A294 E295 I21 I26 F53 K161 N191 D240 K264 M293 A294 E295 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 5.1.1.- 0000287,0006518,0009063,0016853,0016854,0016855,0046872 Q834W6 22392983 356 MKIKQVHVRASKIKLKETFTIALGTIESADSAIVEIETEEGLVGYGEGGPGIFITGETLAGTLETIELFGQAIIGLNPFNIEKIHEVMDKISAFAPAAKAAIDIACYDLMGQKAQLPLYQLLGGYDNQVITDITLGIDEPNVMAQKAVEKVKLGFDTLKIKVGTGIEADIARVKAIREAVGFDIKLRLDANQAWTPKDAVKAIQALADYQIELVEQPVKRRDLEGLKYVTSQVNTTIMADESCFDAQDALELVKKGTVDVINIKLMKCGGIHEALKINQICETAGIECMIGCMAEETTIGITAAAHLAAAQKNITRADLDATFGLETAPVTGGVSLEAKPLLELGEAAGLGIS 3jzu B 2.0 BS02 TYR B 1 I21 F53 K161 D240 K264 C292 M293 A294 E295 I21 F53 K161 D240 K264 C292 M293 A294 E295 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 5.1.1.- 0000287,0006518,0009063,0016853,0016854,0016855,0046872 Q834W6 22392983 356 MKIKQVHVRASKIKLKETFTIALGTIESADSAIVEIETEEGLVGYGEGGPGIFITGETLAGTLETIELFGQAIIGLNPFNIEKIHEVMDKISAFAPAAKAAIDIACYDLMGQKAQLPLYQLLGGYDNQVITDITLGIDEPNVMAQKAVEKVKLGFDTLKIKVGTGIEADIARVKAIREAVGFDIKLRLDANQAWTPKDAVKAIQALADYQIELVEQPVKRRDLEGLKYVTSQVNTTIMADESCFDAQDALELVKKGTVDVINIKLMKCGGIHEALKINQICETAGIECMIGCMAEETTIGITAAAHLAAAQKNITRADLDATFGLETAPVTGGVSLEAKPLLELGEAAGLGISH 3jzu C 2.0 BS02 TYR C 1 I21 F53 I54 K161 D240 K264 C292 A294 E295 I21 F53 I54 K161 D240 K264 C292 A294 E295 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 5.1.1.- 0000287,0006518,0009063,0016853,0016854,0016855,0046872 Q834W6 22392983 356 MKIKQVHVRASKIKLKETFTIALGTIESADSAIVEIETEEGLVGYGEGGPGIFITGETLAGTLETIELFGQAIIGLNPFNIEKIHEVMDKISAFAPAAKAAIDIACYDLMGQKAQLPLYQLLGGYDNQVITDITLGIDEPNVMAQKAVEKVKLGFDTLKIKVGTGIEADIARVKAIREAVGFDIKLRLDANQAWTPKDAVKAIQALADYQIELVEQPVKRRDLEGLKYVTSQVNTTIMADESCFDAQDALELVKKGTVDVINIKLMKCGGIHEALKINQICETAGIECMIGCMAEETTIGITAAAHLAAAQKNITRADLDATFGLETAPVTGGVSLEAKPLLELGEAAGLGISH 3jzu D 2.0 BS02 TYR D 1 F53 K161 D240 K264 C292 M293 A294 E295 F53 K161 D240 K264 C292 M293 A294 E295 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 5.1.1.- 0000287,0006518,0009063,0016853,0016854,0016855,0046872 Q834W6 22392983 356 MKIKQVHVRASKIKLKETFTIALGTIESADSAIVEIETEEGLVGYGEGGPGIFITGETLAGTLETIELFGQAIIGLNPFNIEKIHEVMDKISAFAPAAKAAIDIACYDLMGQKAQLPLYQLLGGYDNQVITDITLGIDEPNVMAQKAVEKVKLGFDTLKIKVGTGIEADIARVKAIREAVGFDIKLRLDANQAWTPKDAVKAIQALADYQIELVEQPVKRRDLEGLKYVTSQVNTTIMADESCFDAQDALELVKKGTVDVINIKLMKCGGIHEALKINQICETAGIECMIGCMAEETTIGITAAAHLAAAQKNITRADLDATFGLETAPVTGGVSLEAKPLLELGEAAGLGISH 3jzu E 2.0 BS02 TYR E 1 I21 F53 K161 D240 K264 M293 A294 E295 I21 F53 K161 D240 K264 M293 A294 E295 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 5.1.1.- 0000287,0006518,0009063,0016853,0016854,0016855,0046872 Q834W6 22392983 356 MKIKQVHVRASKIKLKETFTIALGTIESADSAIVEIETEEGLVGYGEGGPGIFITGETLAGTLETIELFGQAIIGLNPFNIEKIHEVMDKISAFAPAAKAAIDIACYDLMGQKAQLPLYQLLGGYDNQVITDITLGIDEPNVMAQKAVEKVKLGFDTLKIKVGTGIEADIARVKAIREAVGFDIKLRLDANQAWTPKDAVKAIQALADYQIELVEQPVKRRDLEGLKYVTSQVNTTIMADESCFDAQDALELVKKGTVDVINIKLMKCGGIHEALKINQICETAGIECMIGCMAEETTIGITAAAHLAAAQKNITRADLDATFGLETAPVTGGVSLEAKPLLELGEAAGLGIS 3jzu F 2.0 BS02 TYR F 1 I21 F53 K161 D240 K264 C292 M293 A294 E295 I21 F53 K161 D240 K264 C292 M293 A294 E295 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 5.1.1.- 0000287,0006518,0009063,0016853,0016854,0016855,0046872 Q834W6 22392983 356 MKIKQVHVRASKIKLKETFTIALGTIESADSAIVEIETEEGLVGYGEGGPGIFITGETLAGTLETIELFGQAIIGLNPFNIEKIHEVMDKISAFAPAAKAAIDIACYDLMGQKAQLPLYQLLGGYDNQVITDITLGIDEPNVMAQKAVEKVKLGFDTLKIKVGTGIEADIARVKAIREAVGFDIKLRLDANQAWTPKDAVKAIQALADYQIELVEQPVKRRDLEGLKYVTSQVNTTIMADESCFDAQDALELVKKGTVDVINIKLMKCGGIHEALKINQICETAGIECMIGCMAEETTIGITAAAHLAAAQKNITRADLDATFGLETAPVTGGVSLEAKPLLELGEAAGLGISH 3jzu G 2.0 BS02 TYR G 1 F53 K161 D240 K264 C292 A294 E295 F53 K161 D240 K264 C292 A294 E295 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 5.1.1.- 0000287,0006518,0009063,0016853,0016854,0016855,0046872 Q834W6 22392983 356 MKIKQVHVRASKIKLKETFTIALGTIESADSAIVEIETEEGLVGYGEGGPGIFITGETLAGTLETIELFGQAIIGLNPFNIEKIHEVMDKISAFAPAAKAAIDIACYDLMGQKAQLPLYQLLGGYDNQVITDITLGIDEPNVMAQKAVEKVKLGFDTLKIKVGTGIEADIARVKAIREAVGFDIKLRLDANQAWTPKDAVKAIQALADYQIELVEQPVKRRDLEGLKYVTSQVNTTIMADESCFDAQDALELVKKGTVDVINIKLMKCGGIHEALKINQICETAGIECMIGCMAEETTIGITAAAHLAAAQKNITRADLDATFGLETAPVTGGVSLEAKPLLELGEAAGLGISH 3jzu H 2.0 BS02 TYR H 1 I21 F53 K161 D240 K264 C292 M293 A294 E295 I21 F53 K161 D240 K264 C292 M293 A294 E295 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 5.1.1.- 0000287,0006518,0009063,0016853,0016854,0016855,0046872 Q834W6 22392983 356 MKIKQVHVRASKIKLKETFTIALGTIESADSAIVEIETEEGLVGYGEGGPGIFITGETLAGTLETIELFGQAIIGLNPFNIEKIHEVMDKISAFAPAAKAAIDIACYDLMGQKAQLPLYQLLGGYDNQVITDITLGIDEPNVMAQKAVEKVKLGFDTLKIKVGTGIEADIARVKAIREAVGFDIKLRLDANQAWTPKDAVKAIQALADYQIELVEQPVKRRDLEGLKYVTSQVNTTIMADESCFDAQDALELVKKGTVDVINIKLMKCGGIHEALKINQICETAGIECMIGCMAEETTIGITAAAHLAAAQKNITRADLDATFGLETAPVTGGVSLEAKPLLELGEAAGLGISH 3k1g A 2.0 BS02 TYR A 1 I21 F53 K161 D189 D240 K264 C292 A294 E295 I21 F53 K161 D189 D240 K264 C292 A294 E295 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 5.1.1.- 0000287,0006518,0009063,0016853,0016854,0016855,0046872 Q834W6 22392983 356 MKIKQVHVRASKIKLKETFTIALGTIESADSAIVEIETEEGLVGYGEGGPGIFITGETLAGTLETIELFGQAIIGLNPFNIEKIHEVMDKISAFAPAAKAAIDIACYDLMGQKAQLPLYQLLGGYDNQVITDITLGIDEPNVMAQKAVEKVKLGFDTLKIKVGTGIEADIARVKAIREAVGFDIKLRLDANQAWTPKDAVKAIQALADYQIELVEQPVKRRDLEGLKYVTSQVNTTIMADESCFDAQDALELVKKGTVDVINIKLMKCGGIHEALKINQICETAGIECMIGCMAEETTIGITAAAHLAAAQKNITRADLDATFGLETAPVTGGVSLEAKPLLELGEAAGLGISH 3k1g B 2.0 BS02 TYR B 1 I21 F53 K161 D189 D240 K264 M293 A294 E295 I21 F53 K161 D189 D240 K264 M293 A294 E295 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 5.1.1.- 0000287,0006518,0009063,0016853,0016854,0016855,0046872 Q834W6 22392983 356 MKIKQVHVRASKIKLKETFTIALGTIESADSAIVEIETEEGLVGYGEGGPGIFITGETLAGTLETIELFGQAIIGLNPFNIEKIHEVMDKISAFAPAAKAAIDIACYDLMGQKAQLPLYQLLGGYDNQVITDITLGIDEPNVMAQKAVEKVKLGFDTLKIKVGTGIEADIARVKAIREAVGFDIKLRLDANQAWTPKDAVKAIQALADYQIELVEQPVKRRDLEGLKYVTSQVNTTIMADESCFDAQDALELVKKGTVDVINIKLMKCGGIHEALKINQICETAGIECMIGCMAEETTIGITAAAHLAAAQKNITRADLDATFGLETAPVTGGVSLEAKPLLELGEAAGLGIS 3k1g C 2.0 BS02 TYR C 1 I21 F53 K159 K161 D240 K264 C292 M293 E295 I21 F53 K159 K161 D240 K264 C292 M293 E295 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 5.1.1.- 0000287,0006518,0009063,0016853,0016854,0016855,0046872 Q834W6 22392983 356 MKIKQVHVRASKIKLKETFTIALGTIESADSAIVEIETEEGLVGYGEGGPGIFITGETLAGTLETIELFGQAIIGLNPFNIEKIHEVMDKISAFAPAAKAAIDIACYDLMGQKAQLPLYQLLGGYDNQVITDITLGIDEPNVMAQKAVEKVKLGFDTLKIKVGTGIEADIARVKAIREAVGFDIKLRLDANQAWTPKDAVKAIQALADYQIELVEQPVKRRDLEGLKYVTSQVNTTIMADESCFDAQDALELVKKGTVDVINIKLMKCGGIHEALKINQICETAGIECMIGCMAEETTIGITAAAHLAAAQKNITRADLDATFGLETAPVTGGVSLEAKPLLELGEAAGLGISH 3k1g D 2.0 BS02 TYR D 1 F53 I54 K161 D189 D240 K264 E295 F53 I54 K161 D189 D240 K264 E295 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 5.1.1.- 0000287,0006518,0009063,0016853,0016854,0016855,0046872 Q834W6 22392983 356 MKIKQVHVRASKIKLKETFTIALGTIESADSAIVEIETEEGLVGYGEGGPGIFITGETLAGTLETIELFGQAIIGLNPFNIEKIHEVMDKISAFAPAAKAAIDIACYDLMGQKAQLPLYQLLGGYDNQVITDITLGIDEPNVMAQKAVEKVKLGFDTLKIKVGTGIEADIARVKAIREAVGFDIKLRLDANQAWTPKDAVKAIQALADYQIELVEQPVKRRDLEGLKYVTSQVNTTIMADESCFDAQDALELVKKGTVDVINIKLMKCGGIHEALKINQICETAGIECMIGCMAEETTIGITAAAHLAAAQKNITRADLDATFGLETAPVTGGVSLEAKPLLELGEAAGLGISH 3k1g E 2.0 BS02 TYR E 1 I21 F53 K159 K161 D189 D240 K264 C292 M293 A294 E295 I21 F53 K159 K161 D189 D240 K264 C292 M293 A294 E295 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 5.1.1.- 0000287,0006518,0009063,0016853,0016854,0016855,0046872 Q834W6 22392983 356 MKIKQVHVRASKIKLKETFTIALGTIESADSAIVEIETEEGLVGYGEGGPGIFITGETLAGTLETIELFGQAIIGLNPFNIEKIHEVMDKISAFAPAAKAAIDIACYDLMGQKAQLPLYQLLGGYDNQVITDITLGIDEPNVMAQKAVEKVKLGFDTLKIKVGTGIEADIARVKAIREAVGFDIKLRLDANQAWTPKDAVKAIQALADYQIELVEQPVKRRDLEGLKYVTSQVNTTIMADESCFDAQDALELVKKGTVDVINIKLMKCGGIHEALKINQICETAGIECMIGCMAEETTIGITAAAHLAAAQKNITRADLDATFGLETAPVTGGVSLEAKPLLELGEAAGLGISH 3k1g F 2.0 BS02 TYR F 1 F19 F53 I54 K161 D240 K264 E295 F19 F53 I54 K161 D240 K264 E295 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 5.1.1.- 0000287,0006518,0009063,0016853,0016854,0016855,0046872 Q834W6 22392983 356 MKIKQVHVRASKIKLKETFTIALGTIESADSAIVEIETEEGLVGYGEGGPGIFITGETLAGTLETIELFGQAIIGLNPFNIEKIHEVMDKISAFAPAAKAAIDIACYDLMGQKAQLPLYQLLGGYDNQVITDITLGIDEPNVMAQKAVEKVKLGFDTLKIKVGTGIEADIARVKAIREAVGFDIKLRLDANQAWTPKDAVKAIQALADYQIELVEQPVKRRDLEGLKYVTSQVNTTIMADESCFDAQDALELVKKGTVDVINIKLMKCGGIHEALKINQICETAGIECMIGCMAEETTIGITAAAHLAAAQKNITRADLDATFGLETAPVTGGVSLEAKPLLELGEAAGLGISH 3k1g G 2.0 BS02 TYR G 1 I21 F53 K161 D189 D240 K264 M293 A294 E295 I21 F53 K161 D189 D240 K264 M293 A294 E295 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 5.1.1.- 0000287,0006518,0009063,0016853,0016854,0016855,0046872 Q834W6 22392983 356 MKIKQVHVRASKIKLKETFTIALGTIESADSAIVEIETEEGLVGYGEGGPGIFITGETLAGTLETIELFGQAIIGLNPFNIEKIHEVMDKISAFAPAAKAAIDIACYDLMGQKAQLPLYQLLGGYDNQVITDITLGIDEPNVMAQKAVEKVKLGFDTLKIKVGTGIEADIARVKAIREAVGFDIKLRLDANQAWTPKDAVKAIQALADYQIELVEQPVKRRDLEGLKYVTSQVNTTIMADESCFDAQDALELVKKGTVDVINIKLMKCGGIHEALKINQICETAGIECMIGCMAEETTIGITAAAHLAAAQKNITRADLDATFGLETAPVTGGVSLEAKPLLELGEAAGLGISH 3k1g H 2.0 BS02 TYR H 1 I21 F53 K161 N191 D240 K264 M293 A294 E295 I21 F53 K161 N191 D240 K264 M293 A294 E295 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 5.1.1.- 0000287,0006518,0009063,0016853,0016854,0016855,0046872 Q834W6 22392983 356 MKIKQVHVRASKIKLKETFTIALGTIESADSAIVEIETEEGLVGYGEGGPGIFITGETLAGTLETIELFGQAIIGLNPFNIEKIHEVMDKISAFAPAAKAAIDIACYDLMGQKAQLPLYQLLGGYDNQVITDITLGIDEPNVMAQKAVEKVKLGFDTLKIKVGTGIEADIARVKAIREAVGFDIKLRLDANQAWTPKDAVKAIQALADYQIELVEQPVKRRDLEGLKYVTSQVNTTIMADESCFDAQDALELVKKGTVDVINIKLMKCGGIHEALKINQICETAGIECMIGCMAEETTIGITAAAHLAAAQKNITRADLDATFGLETAPVTGGVSLEAKPLLELGEAAGLGIS 3kdz A 2.2 BS01 TYR A 1 F63 Y69 G70 H93 X152 N205 F356 F53 Y59 G60 H83 X142 N193 F344 F63 G70 H93 N205 Y308 R311 F356 Q442 F53 G60 H83 N193 Y296 R299 F344 Q430 4.3.1.23,5.4.3.6 0003824,0004397,0006548,0009403,0016829,0016841,0016853,0017000,0050368,0052883 Q8GMG0 20577998 600 VPVSVDGETLTVEAVRRVAEERATVDVPAESIAKAQKSREIFEGIAEQNIPIFGVTTGYGEMIYMQVDKSKEVELQTNLVRSHSAGVGPLFAEDEARAIVAARLNTLAKGHSAVRPIILERLAQYLNEGITPAIPEIGSLGGDLAPLSHVASTLIGEGYVLRDGRPVETAQVLAERGIEPLELRFKEGLALINGTSGMTGLGSLVVGRALEQAQQAEIVTALLIEAVRGSTSPFLAEGHDIARPHEGQIDTAANMRALMRGSGLTVEHADLRRELQKDKEAGKDVQRSEIYLQKAYSLRAIPQVVGAVRDTLYHARHKLRIELNSANDNPLFFEGKEIFHGANFHGQPIAFAMDFVTIALTQLGVLAERQINRVLNRHLSYGLPEFLVSGDPGLHSGFAGAQYPATALVAENRTIGPASTQSVPSNGDNQDVVSMGLISARNARRVLSNNNKILAVEYLAAAQAVDISGRFDGLSPAAKATYEAVRRLVPTLGVDRYMADDIELVADALSRGEFLRAIARETDIQLR 3kdz A 2.2 BS02 TYR B 1 Y308 R311 Y296 R299 F63 G70 H93 N205 Y308 R311 F356 Q442 F53 G60 H83 N193 Y296 R299 F344 Q430 4.3.1.23,5.4.3.6 0003824,0004397,0006548,0009403,0016829,0016841,0016853,0017000,0050368,0052883 Q8GMG0 20577998 600 VPVSVDGETLTVEAVRRVAEERATVDVPAESIAKAQKSREIFEGIAEQNIPIFGVTTGYGEMIYMQVDKSKEVELQTNLVRSHSAGVGPLFAEDEARAIVAARLNTLAKGHSAVRPIILERLAQYLNEGITPAIPEIGSLGGDLAPLSHVASTLIGEGYVLRDGRPVETAQVLAERGIEPLELRFKEGLALINGTSGMTGLGSLVVGRALEQAQQAEIVTALLIEAVRGSTSPFLAEGHDIARPHEGQIDTAANMRALMRGSGLTVEHADLRRELQKDKEAGKDVQRSEIYLQKAYSLRAIPQVVGAVRDTLYHARHKLRIELNSANDNPLFFEGKEIFHGANFHGQPIAFAMDFVTIALTQLGVLAERQINRVLNRHLSYGLPEFLVSGDPGLHSGFAGAQYPATALVAENRTIGPASTQSVPSNGDNQDVVSMGLISARNARRVLSNNNKILAVEYLAAAQAVDISGRFDGLSPAAKATYEAVRRLVPTLGVDRYMADDIELVADALSRGEFLRAIARETDIQLR 3kdz B 2.2 BS01 TYR A 1 Y308 R311 Y296 R299 F63 G70 H93 N205 Y308 R311 F356 Q442 F53 G60 H83 N193 Y296 R299 F344 Q430 4.3.1.23,5.4.3.6 0003824,0004397,0006548,0009403,0016829,0016841,0016853,0017000,0050368,0052883 Q8GMG0 20577998 600 VPVSVDGETLTVEAVRRVAEERATVDVPAESIAKAQKSREIFEGIAEQNIPIFGVTTGYGEMIYMQVDKSKEVELQTNLVRSHSAGVGPLFAEDEARAIVAARLNTLAKGHSAVRPIILERLAQYLNEGITPAIPEIGSLGGDLAPLSHVASTLIGEGYVLRDGRPVETAQVLAERGIEPLELRFKEGLALINGTSGMTGLGSLVVGRALEQAQQAEIVTALLIEAVRGSTSPFLAEGHDIARPHEGQIDTAANMRALMRGSGLTVEHADLRRELQKDKEAGKDVQRSEIYLQKAYSLRAIPQVVGAVRDTLYHARHKLRIELNSANDNPLFFEGKEIFHGANFHGQPIAFAMDFVTIALTQLGVLAERQINRVLNRHLSYGLPEFLVSGDPGLHSGFAGAQYPATALVAENRTIGPASTQSVPSNGDNQDVVSMGLISARNARRVLSNNNKILAVEYLAAAQAVDISGRFDGLSPAAKATYEAVRRLVPTLGVDRYMADDIELVADALSRGEFLRAIARETDIQLR 3kdz B 2.2 BS02 TYR B 1 F63 Y69 H93 X152 N205 F356 Q442 F53 Y59 H83 X142 N193 F344 Q430 F63 G70 H93 N205 Y308 R311 F356 Q442 F53 G60 H83 N193 Y296 R299 F344 Q430 4.3.1.23,5.4.3.6 0003824,0004397,0006548,0009403,0016829,0016841,0016853,0017000,0050368,0052883 Q8GMG0 20577998 600 VPVSVDGETLTVEAVRRVAEERATVDVPAESIAKAQKSREIFEGIAEQNIPIFGVTTGYGEMIYMQVDKSKEVELQTNLVRSHSAGVGPLFAEDEARAIVAARLNTLAKGHSAVRPIILERLAQYLNEGITPAIPEIGSLGGDLAPLSHVASTLIGEGYVLRDGRPVETAQVLAERGIEPLELRFKEGLALINGTSGMTGLGSLVVGRALEQAQQAEIVTALLIEAVRGSTSPFLAEGHDIARPHEGQIDTAANMRALMRGSGLTVEHADLRRELQKDKEAGKDVQRSEIYLQKAYSLRAIPQVVGAVRDTLYHARHKLRIELNSANDNPLFFEGKEIFHGANFHGQPIAFAMDFVTIALTQLGVLAERQINRVLNRHLSYGLPEFLVSGDPGLHSGFAGAQYPATALVAENRTIGPASTQSVPSNGDNQDVVSMGLISARNARRVLSNNNKILAVEYLAAAQAVDISGRFDGLSPAAKATYEAVRRLVPTLGVDRYMADDIELVADALSRGEFLRAIARETDIQLR 3kum A 1.9 BS02 TYR A 1 I21 F53 I54 K161 D240 K264 A294 E295 I21 F53 I54 K161 D240 K264 A294 E295 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 5.1.1.- 0000287,0006518,0009063,0016853,0016854,0016855,0046872 Q834W6 22392983 356 MKIKQVHVRASKIKLKETFTIALGTIESADSAIVEIETEEGLVGYGEGGPGIFITGETLAGTLETIELFGQAIIGLNPFNIEKIHEVMDKISAFAPAAKAAIDIACYDLMGQKAQLPLYQLLGGYDNQVITDITLGIDEPNVMAQKAVEKVKLGFDTLKIKVGTGIEADIARVKAIREAVGFDIKLRLDANQAWTPKDAVKAIQALADYQIELVEQPVKRRDLEGLKYVTSQVNTTIMADESCFDAQDALELVKKGTVDVINIKLMKCGGIHEALKINQICETAGIECMIGCMAEETTIGITAAAHLAAAQKNITRADLDATFGLETAPVTGGVSLEAKPLLELGEAAGLGISH 3kum B 1.9 BS02 TYR B 1 I21 F53 K161 D189 D240 K264 M293 A294 E295 I21 F53 K161 D189 D240 K264 M293 A294 E295 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 5.1.1.- 0000287,0006518,0009063,0016853,0016854,0016855,0046872 Q834W6 22392983 356 MKIKQVHVRASKIKLKETFTIALGTIESADSAIVEIETEEGLVGYGEGGPGIFITGETLAGTLETIELFGQAIIGLNPFNIEKIHEVMDKISAFAPAAKAAIDIACYDLMGQKAQLPLYQLLGGYDNQVITDITLGIDEPNVMAQKAVEKVKLGFDTLKIKVGTGIEADIARVKAIREAVGFDIKLRLDANQAWTPKDAVKAIQALADYQIELVEQPVKRRDLEGLKYVTSQVNTTIMADESCFDAQDALELVKKGTVDVINIKLMKCGGIHEALKINQICETAGIECMIGCMAEETTIGITAAAHLAAAQKNITRADLDATFGLETAPVTGGVSLEAKPLLELGEAAGLGIS 3kum C 1.9 BS02 TYR C 1 F53 K161 D240 K264 C292 A294 E295 F53 K161 D240 K264 C292 A294 E295 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 5.1.1.- 0000287,0006518,0009063,0016853,0016854,0016855,0046872 Q834W6 22392983 356 MKIKQVHVRASKIKLKETFTIALGTIESADSAIVEIETEEGLVGYGEGGPGIFITGETLAGTLETIELFGQAIIGLNPFNIEKIHEVMDKISAFAPAAKAAIDIACYDLMGQKAQLPLYQLLGGYDNQVITDITLGIDEPNVMAQKAVEKVKLGFDTLKIKVGTGIEADIARVKAIREAVGFDIKLRLDANQAWTPKDAVKAIQALADYQIELVEQPVKRRDLEGLKYVTSQVNTTIMADESCFDAQDALELVKKGTVDVINIKLMKCGGIHEALKINQICETAGIECMIGCMAEETTIGITAAAHLAAAQKNITRADLDATFGLETAPVTGGVSLEAKPLLELGEAAGLGISH 3kum D 1.9 BS02 TYR D 1 I21 F53 I54 K161 D240 K264 C292 A294 E295 I21 F53 I54 K161 D240 K264 C292 A294 E295 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 5.1.1.- 0000287,0006518,0009063,0016853,0016854,0016855,0046872 Q834W6 22392983 356 MKIKQVHVRASKIKLKETFTIALGTIESADSAIVEIETEEGLVGYGEGGPGIFITGETLAGTLETIELFGQAIIGLNPFNIEKIHEVMDKISAFAPAAKAAIDIACYDLMGQKAQLPLYQLLGGYDNQVITDITLGIDEPNVMAQKAVEKVKLGFDTLKIKVGTGIEADIARVKAIREAVGFDIKLRLDANQAWTPKDAVKAIQALADYQIELVEQPVKRRDLEGLKYVTSQVNTTIMADESCFDAQDALELVKKGTVDVINIKLMKCGGIHEALKINQICETAGIECMIGCMAEETTIGITAAAHLAAAQKNITRADLDATFGLETAPVTGGVSLEAKPLLELGEAAGLGISH 3kum E 1.9 BS02 TYR E 1 I21 F53 K161 D240 K264 C292 A294 E295 I21 F53 K161 D240 K264 C292 A294 E295 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 5.1.1.- 0000287,0006518,0009063,0016853,0016854,0016855,0046872 Q834W6 22392983 356 MKIKQVHVRASKIKLKETFTIALGTIESADSAIVEIETEEGLVGYGEGGPGIFITGETLAGTLETIELFGQAIIGLNPFNIEKIHEVMDKISAFAPAAKAAIDIACYDLMGQKAQLPLYQLLGGYDNQVITDITLGIDEPNVMAQKAVEKVKLGFDTLKIKVGTGIEADIARVKAIREAVGFDIKLRLDANQAWTPKDAVKAIQALADYQIELVEQPVKRRDLEGLKYVTSQVNTTIMADESCFDAQDALELVKKGTVDVINIKLMKCGGIHEALKINQICETAGIECMIGCMAEETTIGITAAAHLAAAQKNITRADLDATFGLETAPVTGGVSLEAKPLLELGEAAGLGISH 3kum F 1.9 BS02 TYR F 1 I21 F53 I54 K161 D240 K264 A294 E295 I21 F53 I54 K161 D240 K264 A294 E295 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 5.1.1.- 0000287,0006518,0009063,0016853,0016854,0016855,0046872 Q834W6 22392983 356 MKIKQVHVRASKIKLKETFTIALGTIESADSAIVEIETEEGLVGYGEGGPGIFITGETLAGTLETIELFGQAIIGLNPFNIEKIHEVMDKISAFAPAAKAAIDIACYDLMGQKAQLPLYQLLGGYDNQVITDITLGIDEPNVMAQKAVEKVKLGFDTLKIKVGTGIEADIARVKAIREAVGFDIKLRLDANQAWTPKDAVKAIQALADYQIELVEQPVKRRDLEGLKYVTSQVNTTIMADESCFDAQDALELVKKGTVDVINIKLMKCGGIHEALKINQICETAGIECMIGCMAEETTIGITAAAHLAAAQKNITRADLDATFGLETAPVTGGVSLEAKPLLELGEAAGLGISH 3kum G 1.9 BS02 TYR G 1 I21 F53 K161 D240 K264 A294 E295 I21 F53 K161 D240 K264 A294 E295 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 5.1.1.- 0000287,0006518,0009063,0016853,0016854,0016855,0046872 Q834W6 22392983 356 MKIKQVHVRASKIKLKETFTIALGTIESADSAIVEIETEEGLVGYGEGGPGIFITGETLAGTLETIELFGQAIIGLNPFNIEKIHEVMDKISAFAPAAKAAIDIACYDLMGQKAQLPLYQLLGGYDNQVITDITLGIDEPNVMAQKAVEKVKLGFDTLKIKVGTGIEADIARVKAIREAVGFDIKLRLDANQAWTPKDAVKAIQALADYQIELVEQPVKRRDLEGLKYVTSQVNTTIMADESCFDAQDALELVKKGTVDVINIKLMKCGGIHEALKINQICETAGIECMIGCMAEETTIGITAAAHLAAAQKNITRADLDATFGLETAPVTGGVSLEAKPLLELGEAAGLGISH 3kum H 1.9 BS02 TYR H 1 I21 F53 K161 D189 D240 A294 E295 I21 F53 K161 D189 D240 A294 E295 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 F19 P50 F53 T134 K159 K161 D189 N191 E215 D240 E241 S242 N262 K264 G291 C292 M293 A317 D318 L319 5.1.1.- 0000287,0006518,0009063,0016853,0016854,0016855,0046872 Q834W6 22392983 356 MKIKQVHVRASKIKLKETFTIALGTIESADSAIVEIETEEGLVGYGEGGPGIFITGETLAGTLETIELFGQAIIGLNPFNIEKIHEVMDKISAFAPAAKAAIDIACYDLMGQKAQLPLYQLLGGYDNQVITDITLGIDEPNVMAQKAVEKVKLGFDTLKIKVGTGIEADIARVKAIREAVGFDIKLRLDANQAWTPKDAVKAIQALADYQIELVEQPVKRRDLEGLKYVTSQVNTTIMADESCFDAQDALELVKKGTVDVINIKLMKCGGIHEALKINQICETAGIECMIGCMAEETTIGITAAAHLAAAQKNITRADLDATFGLETAPVTGGVSLEAKPLLELGEAAGLGIS 3mo4 A 1.901 BS01 TYR A 1 H36 H85 D172 H30 H79 D166 ? 0004560,0005764,0005975,0006004,0016139,0016787 B7GNN8 22138995 479 AGINLNYLANVRPSSRQLAWQRMEMYAFLHFGMNTMTDREWGLGHEDPALFNPRNVDVDQWMDALVAGGMAGVILTCKHHDGFCLWPSRLTRHTVASSPWREGKGDLVREVSESARRHGLKFGVYLSPWDRTEESYGKGKAYDDFYVGQLTELLTQYGPIFSVWLDGANGEGKNGKTQYYDWDRYYNVIRSLQPDAVISVCGPDVRWAGNEAGHVRDNEWSVVPRRLRSATVSSQDDDLGSREAVAGYGDNVCWYPAEVDTSIRPGWFYHQSEDDKVMSADQLFDLWLSAVGGNSSLLLNIPPSPEGLLAEPDVQSLKGLGRRVSEFREALASVRCEARTSSASAAAAHLVDGNRDTFWRPDADDAAPAITLTLPQPTTINAIVIEEAIEHGQRIEHLRVTGALPDGTERVLGQAGTVGYRRILRFDDVEVSSVTLHVDGSRLAPMISRAAAVRI 3o7b A 1.45 BS01 TYR A 1 R153 S191 L192 G193 R153 S191 L192 G193 2.1.1.- 0006364,0008168,0019843,0032259,0042254,0070037,0070475 O29524 21087996 220 MGSAFVFLEASLELIPQKIRGHPAVRADAIRRGKRPEKILLDDSKHHTAMKSLEFREKRGRPDIVHQCLLLLLDSPLRDFEVYVHTLNGEIIWVNRETRLPRNYNRFVGLMEKLFEERRITAGDTTLIEFKDVGLRDIVRGRDVLLFREKGGRFEFSELLDGDVAVCIGAFPHGDFFEETLRELGEFKEVSLGTESYTSLYVTSRVLCEYERVRAH 3pg9 A 2.35 BS01 TYR A 1 S31 G33 Q34 E35 R36 V38 S31 G33 Q34 E35 R36 V38 2.5.1.54 0003849,0008652,0009058,0009073,0009423,0016740,0016832 Q9WYH8 21282100 339 MIVVLKPGSTEEDIRKVVKLAESYNLKCHISKGQERTVIGIIGDDRYVVADKFESLDCVESVVRVLKPYKLVSREFHPEDTVIDLGDVKIGNGYFTIIAGPCSVEGREMLMETAHFLSELGVKVLRGGAYKPRTSPYSFQGLGEKGLEYLREAADKYGMYVVTEALGEDDLPKVAEYADIIQIGARNAQNFRLLSKAGSYNKPVLLKRGFMNTIEEFLLSAEYIANSGNTKIILCERGIRTFEKATRNTLDISAVPIIRKESHLPILVDPSHSGGRRDLVIPLSRAAIAVGAHGIIVEVHPEPEKALSDGKQSLDFELFKELVQEMKKLADALGVKVN 3pg9 A 2.35 BS02 TYR A 2 M1 G40 I41 I42 G43 L66 M1 G40 I41 I42 G43 L66 2.5.1.54 0003849,0008652,0009058,0009073,0009423,0016740,0016832 Q9WYH8 21282100 340 MIVVLKPGSTEEDIRKVVKLAESYNLKCHISKGQERTVIGIIGDDRYVVADKFESLDCVESVVRVLKPYKLVSREFHPEDTVIDLGDVKIGNGYFTIIAGPCSVEGREMLMETAHFLSELGVKVLRGGAYKPRTSPYSFQGLGEKGLEYLREAADKYGMYVVTEALGEDDLPKVAEYADIIQIGARNAQNFRLLSKAGSYNKPVLLKRGFMNTIEEFLLSAEYIANSGNTKIILCERGIRTFEKATRNTLDISAVPIIRKESHLPILVDPSHSGGRRDLVIPLSRAAIAVGAHGIIVEVHPEPEKALSDGKQSLDFELFKELVQEMKKLADALGVKVN 3pg9 B 2.35 BS01 TYR B 1 M1 G40 I41 I42 G43 L66 M1 G40 I41 I42 G43 L66 2.5.1.54 0003849,0008652,0009058,0009073,0009423,0016740,0016832 Q9WYH8 21282100 339 MIVVLKPGSTEEDIRKVVKLAESYNLKCHISKGQERTVIGIIGDDRYVVADKFESLDCVESVVRVLKPYKLVSREFHPEDTVIDLGDVKIGNGYFTIIAGPCSVEGREMLMETAHFLSELGVKVLRGGAYKPRTSPYSFQGLGEKGLEYLREAADKYGMYVVTEALGEDDLPKVAEYADIIQIGARNAQNFRLLSKAGSYNKPVLLKRGFMNTIEEFLLSAEYIANSGNTKIILCERGIRTFEKATRNTLDISAVPIIRKESHLPILVDPSHSGGRRDLVIPLSRAAIAVGAHGIIVEVHPEPEKALSDGKQSLDFELFKELVQEMKKLADALGVKVN 3pg9 B 2.35 BS02 TYR B 2 S31 G33 Q34 E35 R36 S31 G33 Q34 E35 R36 2.5.1.54 0003849,0008652,0009058,0009073,0009423,0016740,0016832 Q9WYH8 21282100 340 MIVVLKPGSTEEDIRKVVKLAESYNLKCHISKGQERTVIGIIGDDRYVVADKFESLDCVESVVRVLKPYKLVSREFHPEDTVIDLGDVKIGNGYFTIIAGPCSVEGREMLMETAHFLSELGVKVLRGGAYKPRTSPYSFQGLGEKGLEYLREAADKYGMYVVTEALGEDDLPKVAEYADIIQIGARNAQNFRLLSKAGSYNKPVLLKRGFMNTIEEFLLSAEYIANSGNTKIILCERGIRTFEKATRNTLDISAVPIIRKESHLPILVDPSHSGGRRDLVIPLSRAAIAVGAHGIIVEVHPEPEKALSDGKQSLDFELFKELVQEMKKLADALGVKVN 3pg9 C 2.35 BS01 TYR C 1 M1 I41 I42 G43 L66 M1 I41 I42 G43 L66 2.5.1.54 0003849,0008652,0009058,0009073,0009423,0016740,0016832 Q9WYH8 21282100 339 MIVVLKPGSTEEDIRKVVKLAESYNLKCHISKGQERTVIGIIGDDRYVVADKFESLDCVESVVRVLKPYKLVSREFHPEDTVIDLGDVKIGNGYFTIIAGPCSVEGREMLMETAHFLSELGVKVLRGGAYKPRTSPYSFQGLGEKGLEYLREAADKYGMYVVTEALGEDDLPKVAEYADIIQIGARNAQNFRLLSKAGSYNKPVLLKRGFMNTIEEFLLSAEYIANSGNTKIILCERGIRTFEKATRNTLDISAVPIIRKESHLPILVDPSHSGGRRDLVIPLSRAAIAVGAHGIIVEVHPEPEKALSDGKQSLDFELFKELVQEMKKLADALGVKVN 3pg9 C 2.35 BS02 TYR C 2 S31 Q34 E35 R36 V38 S31 Q34 E35 R36 V38 2.5.1.54 0003849,0008652,0009058,0009073,0009423,0016740,0016832 Q9WYH8 21282100 340 MIVVLKPGSTEEDIRKVVKLAESYNLKCHISKGQERTVIGIIGDDRYVVADKFESLDCVESVVRVLKPYKLVSREFHPEDTVIDLGDVKIGNGYFTIIAGPCSVEGREMLMETAHFLSELGVKVLRGGAYKPRTSPYSFQGLGEKGLEYLREAADKYGMYVVTEALGEDDLPKVAEYADIIQIGARNAQNFRLLSKAGSYNKPVLLKRGFMNTIEEFLLSAEYIANSGNTKIILCERGIRTFEKATRNTLDISAVPIIRKESHLPILVDPSHSGGRRDLVIPLSRAAIAVGAHGIIVEVHPEPEKALSDGKQSLDFELFKELVQEMKKLADALGVKVN 3pg9 D 2.35 BS01 TYR D 1 S31 G33 Q34 E35 R36 V38 S31 G33 Q34 E35 R36 V38 2.5.1.54 0003849,0008652,0009058,0009073,0009423,0016740,0016832 Q9WYH8 21282100 339 MIVVLKPGSTEEDIRKVVKLAESYNLKCHISKGQERTVIGIIGDDRYVVADKFESLDCVESVVRVLKPYKLVSREFHPEDTVIDLGDVKIGNGYFTIIAGPCSVEGREMLMETAHFLSELGVKVLRGGAYKPRTSPYSFQGLGEKGLEYLREAADKYGMYVVTEALGEDDLPKVAEYADIIQIGARNAQNFRLLSKAGSYNKPVLLKRGFMNTIEEFLLSAEYIANSGNTKIILCERGIRTFEKATRNTLDISAVPIIRKESHLPILVDPSHSGGRRDLVIPLSRAAIAVGAHGIIVEVHPEPEKALSDGKQSLDFELFKELVQEMKKLADALGVKVN 3pg9 D 2.35 BS02 TYR H 1 M1 G40 I41 I42 G43 M1 G40 I41 I42 G43 2.5.1.54 0003849,0008652,0009058,0009073,0009423,0016740,0016832 Q9WYH8 21282100 339 MIVVLKPGSTEEDIRKVVKLAESYNLKCHISKGQERTVIGIIGDDRYVVADKFESLDCVESVVRVLKPYKLVSREFHPEDTVIDLGDVKIGNGYFTIIAGPCSVEGREMLMETAHFLSELGVKVLRGGAYKPRTSPYSFQGLGEKGLEYLREAADKYGMYVVTEALGEDDLPKVAEYADIIQIGARNAQNFRLLSKAGSYNKPVLLKRGFMNTIEEFLLSAEYIANSGNTKIILCERGIRTFEKATRNTLDISAVPIIRKESHLPILVDPSHSGGRRDLVIPLSRAAIAVGAHGIIVEVHPEPEKALSDGKQSLDFELFKELVQEMKKLADALGVKVN 3pg9 E 2.35 BS01 TYR C 1 S31 G33 Q34 E35 R36 V38 S31 G33 Q34 E35 R36 V38 2.5.1.54 0003849,0008652,0009058,0009073,0009423,0016740,0016832 Q9WYH8 21282100 339 MIVVLKPGSTEEDIRKVVKLAESYNLKCHISKGQERTVIGIIGDDRYVVADKFESLDCVESVVRVLKPYKLVSREFHPEDTVIDLGDVKIGNGYFTIIAGPCSVEGREMLMETAHFLSELGVKVLRGGAYKPRTSPYSFQGLGEKGLEYLREAADKYGMYVVTEALGEDDLPKVAEYADIIQIGARNAQNFRLLSKAGSYNKPVLLKRGFMNTIEEFLLSAEYIANSGNTKIILCERGIRTFEKATRNTLDISAVPIIRKESHLPILVDPSHSGGRRDLVIPLSRAAIAVGAHGIIVEVHPEPEKALSDGKQSLDFELFKELVQEMKKLADALGVKVN 3pg9 E 2.35 BS02 TYR C 2 M1 I41 I42 G43 L66 M1 I41 I42 G43 L66 2.5.1.54 0003849,0008652,0009058,0009073,0009423,0016740,0016832 Q9WYH8 21282100 340 MIVVLKPGSTEEDIRKVVKLAESYNLKCHISKGQERTVIGIIGDDRYVVADKFESLDCVESVVRVLKPYKLVSREFHPEDTVIDLGDVKIGNGYFTIIAGPCSVEGREMLMETAHFLSELGVKVLRGGAYKPRTSPYSFQGLGEKGLEYLREAADKYGMYVVTEALGEDDLPKVAEYADIIQIGARNAQNFRLLSKAGSYNKPVLLKRGFMNTIEEFLLSAEYIANSGNTKIILCERGIRTFEKATRNTLDISAVPIIRKESHLPILVDPSHSGGRRDLVIPLSRAAIAVGAHGIIVEVHPEPEKALSDGKQSLDFELFKELVQEMKKLADALGVKVN 3pg9 F 2.35 BS01 TYR A 1 M1 I41 I42 G43 L66 M1 I41 I42 G43 L66 2.5.1.54 0003849,0008652,0009058,0009073,0009423,0016740,0016832 Q9WYH8 21282100 339 MIVVLKPGSTEEDIRKVVKLAESYNLKCHISKGQERTVIGIIGDDRYVVADKFESLDCVESVVRVLKPYKLVSREFHPEDTVIDLGDVKIGNGYFTIIAGPCSVEGREMLMETAHFLSELGVKVLRGGAYKPRTSPYSFQGLGEKGLEYLREAADKYGMYVVTEALGEDDLPKVAEYADIIQIGARNAQNFRLLSKAGSYNKPVLLKRGFMNTIEEFLLSAEYIANSGNTKIILCERGIRTFEKATRNTLDISAVPIIRKESHLPILVDPSHSGGRRDLVIPLSRAAIAVGAHGIIVEVHPEPEKALSDGKQSLDFELFKELVQEMKKLADALGVKVN 3pg9 F 2.35 BS02 TYR A 2 S31 Q34 E35 R36 V38 S31 Q34 E35 R36 V38 2.5.1.54 0003849,0008652,0009058,0009073,0009423,0016740,0016832 Q9WYH8 21282100 340 MIVVLKPGSTEEDIRKVVKLAESYNLKCHISKGQERTVIGIIGDDRYVVADKFESLDCVESVVRVLKPYKLVSREFHPEDTVIDLGDVKIGNGYFTIIAGPCSVEGREMLMETAHFLSELGVKVLRGGAYKPRTSPYSFQGLGEKGLEYLREAADKYGMYVVTEALGEDDLPKVAEYADIIQIGARNAQNFRLLSKAGSYNKPVLLKRGFMNTIEEFLLSAEYIANSGNTKIILCERGIRTFEKATRNTLDISAVPIIRKESHLPILVDPSHSGGRRDLVIPLSRAAIAVGAHGIIVEVHPEPEKALSDGKQSLDFELFKELVQEMKKLADALGVKVN 3pg9 G 2.35 BS01 TYR B 1 S31 G33 Q34 E35 R36 V38 S31 G33 Q34 E35 R36 V38 2.5.1.54 0003849,0008652,0009058,0009073,0009423,0016740,0016832 Q9WYH8 21282100 339 MIVVLKPGSTEEDIRKVVKLAESYNLKCHISKGQERTVIGIIGDDRYVVADKFESLDCVESVVRVLKPYKLVSREFHPEDTVIDLGDVKIGNGYFTIIAGPCSVEGREMLMETAHFLSELGVKVLRGGAYKPRTSPYSFQGLGEKGLEYLREAADKYGMYVVTEALGEDDLPKVAEYADIIQIGARNAQNFRLLSKAGSYNKPVLLKRGFMNTIEEFLLSAEYIANSGNTKIILCERGIRTFEKATRNTLDISAVPIIRKESHLPILVDPSHSGGRRDLVIPLSRAAIAVGAHGIIVEVHPEPEKALSDGKQSLDFELFKELVQEMKKLADALGVKVN 3pg9 G 2.35 BS02 TYR B 2 M1 G40 I41 I42 G43 D45 V65 M1 G40 I41 I42 G43 D45 V65 2.5.1.54 0003849,0008652,0009058,0009073,0009423,0016740,0016832 Q9WYH8 21282100 340 MIVVLKPGSTEEDIRKVVKLAESYNLKCHISKGQERTVIGIIGDDRYVVADKFESLDCVESVVRVLKPYKLVSREFHPEDTVIDLGDVKIGNGYFTIIAGPCSVEGREMLMETAHFLSELGVKVLRGGAYKPRTSPYSFQGLGEKGLEYLREAADKYGMYVVTEALGEDDLPKVAEYADIIQIGARNAQNFRLLSKAGSYNKPVLLKRGFMNTIEEFLLSAEYIANSGNTKIILCERGIRTFEKATRNTLDISAVPIIRKESHLPILVDPSHSGGRRDLVIPLSRAAIAVGAHGIIVEVHPEPEKALSDGKQSLDFELFKELVQEMKKLADALGVKVN 3pg9 H 2.35 BS01 TYR D 1 M1 I41 I42 G43 L66 M1 I41 I42 G43 L66 2.5.1.54 0003849,0008652,0009058,0009073,0009423,0016740,0016832 Q9WYH8 21282100 339 MIVVLKPGSTEEDIRKVVKLAESYNLKCHISKGQERTVIGIIGDDRYVVADKFESLDCVESVVRVLKPYKLVSREFHPEDTVIDLGDVKIGNGYFTIIAGPCSVEGREMLMETAHFLSELGVKVLRGGAYKPRTSPYSFQGLGEKGLEYLREAADKYGMYVVTEALGEDDLPKVAEYADIIQIGARNAQNFRLLSKAGSYNKPVLLKRGFMNTIEEFLLSAEYIANSGNTKIILCERGIRTFEKATRNTLDISAVPIIRKESHLPILVDPSHSGGRRDLVIPLSRAAIAVGAHGIIVEVHPEPEKALSDGKQSLDFELFKELVQEMKKLADALGVKVN 3pg9 H 2.35 BS02 TYR H 1 S31 G33 Q34 E35 R36 V38 S31 G33 Q34 E35 R36 V38 2.5.1.54 0003849,0008652,0009058,0009073,0009423,0016740,0016832 Q9WYH8 21282100 339 MIVVLKPGSTEEDIRKVVKLAESYNLKCHISKGQERTVIGIIGDDRYVVADKFESLDCVESVVRVLKPYKLVSREFHPEDTVIDLGDVKIGNGYFTIIAGPCSVEGREMLMETAHFLSELGVKVLRGGAYKPRTSPYSFQGLGEKGLEYLREAADKYGMYVVTEALGEDDLPKVAEYADIIQIGARNAQNFRLLSKAGSYNKPVLLKRGFMNTIEEFLLSAEYIANSGNTKIILCERGIRTFEKATRNTLDISAVPIIRKESHLPILVDPSHSGGRRDLVIPLSRAAIAVGAHGIIVEVHPEPEKALSDGKQSLDFELFKELVQEMKKLADALGVKVN 3vgj A 2.212 BS01 TYR A 1 Y60 G62 E64 W94 F99 I172 Y188 Q192 D195 Q210 Y41 G43 E45 W75 F80 I153 Y169 Q173 D176 Q191 6.1.1.1 0000166,0004812,0004831,0005524,0005737,0006412,0006418,0006437,0044164,0044650,0046789,0046872 Q8IAR7 22068597 401 EESKIEDVDKILNDILSISSECIQPDELRVKLLLKRKLICYDGFEPSGRMHIAQGLLKSIIVNKLTSNGCTFIFWIADWFAHLNNKMSGDLKKIKKVGSYFIEVWKSCGMNMENVQFLWASEEINKKPNEYWSLVLDISRSFNINRMKRCLKIMGRSEGEENYCSQILYPCMQCADIFFLNVDICQLGIDQRKVNMLAREYCDIKKIKKKPVILSHGMLPGLLEGQEKMSKSDENSAIFMDDSESDVNRKIKKAYCPPNVIENNPIYAYAKSIIFPSYNEFNLVRKEKNGGDKTYYTLQELEHDYVNGFIHPLDLKDNVAMYINKLLQPVRDHFQNNIEAKNLLNEIKKYKVT 3vgj B 2.212 BS01 TYR B 1 Y60 G62 E64 W94 F99 I172 Y188 Q192 D195 L206 Q210 Y43 G45 E47 W77 F82 I155 Y171 Q175 D178 L189 Q193 6.1.1.1 0000166,0004812,0004831,0005524,0005737,0006412,0006418,0006437,0044164,0044650,0046789,0046872 Q8IAR7 22068597 401 AQEESKIEDVDKILNDILSISSECIQPDELRVKLLLKRKLICYDGFEPSGRMHIAQGLLKSIIVNKLTSNGCTFIFWIADWFAHLNNKMSGDLKKIKKVGSYFIEVWKSCGMNMENVQFLWASEEINKKPNEYWSLVLDISRSFNINRMKRCLKIMGRSEGEENYCSQILYPCMQCADIFFLNVDICQLGIDQRKVNMLAREYCDIKKIKKKPVILSHGMLPGLLEGQEKMSKSDENSAIFMDDSESDVNRKIKKAYCPPNVIENNPIYAYAKSIIFPSYNEFNLVRKEKNGGDKTYYTLQELEHDYVNGFIHPLDLKDNVAMYINKLLQPVRDHFQNNIEAKNLLNEIKKYKVTK 3wol A 1.74 BS02 TYR A 1 H86 W216 I652 T653 G654 S657 D674 G675 H62 W192 I628 T629 G630 S633 D650 G651 3.4.14.- 0004175,0004177,0006508,0008239,0009056,0042802,0042803,0051603,0070009 V5YM14 24827749 802 GEGMWVPQQLPEIAGPLKKAGLKLSPQQISDLTGDPMGAVVALGGCTASFVSPNGLVVTNHHCAYGAIQLNSTAENNLIKNGFNAPTTADEVSAGPNARVFVLDEITDVTKDAKAAIAAAGDDALARTKALEAFEKKLIADCEAEAGFRCRLYSFSGGNTYRLFKNLEIKDVRLAYAPPGSVGKFGGDIDNWMWPRHTGDFAFYRAYVGKDGKPAAFSKDNVPYQPKHWLKFADQPLGAGDFVMVAGYPGSTNRYALAAEFDNTAQWTYPTIARHYKNQIAMVEAAGKQNADIQVKYAATMAGWNNTSKNYDGQLEGFKRIDAAGQKLREEAAVLGWLKGQGAKGQPALDAHAKLLDLLEQSKATRDRDLTLALFNNTAMLGSATQLYRLSIEREKPNAERESGYQERDLPAIEGGLKQLERRYVAAMDRQLQEYWLNEYIKLPADQRVAAVDAWLGGNDAAAVKRALDRLAGTKLGSTEERLKWFAADRKAFEASNDPAIQYAVAVMPTLLKLEQERKTRAGENLAARPVYLQALADYKKSQGEFVYPDANLSLRITFGNVMGYAPKDGMEYTPFTTLEGVVAKETGQDPFDSPKALLDAVAAKRYGGLEDKRIGSVPVNYLSDLDITGGNSGSPVLDAHGKLVGLAFDGNWESVSSNWVFDPKMTRMIAVDGRYLRWIMQEVYPAPQLLKEMNV 3wol B 1.74 BS02 TYR B 1 H86 W216 I652 T653 G654 S657 D674 G675 H62 W192 I628 T629 G630 S633 D650 G651 3.4.14.- 0004175,0004177,0006508,0008239,0009056,0042802,0042803,0051603,0070009 V5YM14 24827749 802 GEGMWVPQQLPEIAGPLKKAGLKLSPQQISDLTGDPMGAVVALGGCTASFVSPNGLVVTNHHCAYGAIQLNSTAENNLIKNGFNAPTTADEVSAGPNARVFVLDEITDVTKDAKAAIAAAGDDALARTKALEAFEKKLIADCEAEAGFRCRLYSFSGGNTYRLFKNLEIKDVRLAYAPPGSVGKFGGDIDNWMWPRHTGDFAFYRAYVGKDGKPAAFSKDNVPYQPKHWLKFADQPLGAGDFVMVAGYPGSTNRYALAAEFDNTAQWTYPTIARHYKNQIAMVEAAGKQNADIQVKYAATMAGWNNTSKNYDGQLEGFKRIDAAGQKLREEAAVLGWLKGQGAKGQPALDAHAKLLDLLEQSKATRDRDLTLALFNNTAMLGSATQLYRLSIEREKPNAERESGYQERDLPAIEGGLKQLERRYVAAMDRQLQEYWLNEYIKLPADQRVAAVDAWLGGNDAAAVKRALDRLAGTKLGSTEERLKWFAADRKAFEASNDPAIQYAVAVMPTLLKLEQERKTRAGENLAARPVYLQALADYKKSQGEFVYPDANLSLRITFGNVMGYAPKDGMEYTPFTTLEGVVAKETGQDPFDSPKALLDAVAAKRYGGLEDKRIGSVPVNYLSDLDITGGNSGSPVLDAHGKLVGLAFDGNWESVSSNWVFDPKMTRMIAVDGRYLRWIMQEVYPAPQLLKEMNV 3wom A 1.86 BS02 TYR A 1 H86 W216 I652 T653 G654 S657 D674 G675 H62 W192 I628 T629 G630 S633 D650 G651 3.4.14.- 0004175,0004177,0006508,0008239,0009056,0042802,0042803,0051603,0070009 V5YM14 24827749 802 GEGMWVPQQLPEIAGPLKKAGLKLSPQQISDLTGDPMGAVVALGGCTASFVSPNGLVVTNHHCAYGAIQLNSTAENNLIKNGFNAPTTADEVSAGPNARVFVLDEITDVTKDAKAAIAAAGDDALARTKALEAFEKKLIADCEAEAGFRCRLYSFSGGNTYRLFKNLEIKDVRLAYAPPGSVGKFGGDIDNWMWPRHTGDFAFYRAYVGKDGKPAAFSKDNVPYQPKHWLKFADQPLGAGDFVMVAGYPGSTNRYALAAEFDNTAQWTYPTIARHYKNQIAMVEAAGKQNADIQVKYAATMAGWNNTSKNYDGQLEGFKRIDAAGQKLREEAAVLGWLKGQGAKGQPALDAHAKLLDLLEQSKATRDRDLTLALFNNTAMLGSATQLYRLSIEREKPNAERESGYQERDLPAIEGGLKQLERRYVAAMDRQLQEYWLNEYIKLPADQRVAAVDAWLGGNDAAAVKRALDRLAGTKLGSTEERLKWFAADRKAFEASNDPAIQYAVAVMPTLLKLEQERKTRAGENLAARPVYLQALADYKKSQGEFVYPDANLSLRITFGNVMGYAPKDGMEYTPFTTLEGVVAKETGQDPFDSPKALLDAVAAKRYGGLEDKRIGSVPVNYLSDLDITGGNSGSPVLDAHGKLVGLAFDGNWESVSSNWVFDPKMTRMIAVDGRYLRWIMQEVYPAPQLLKEMNVG 3wom B 1.86 BS02 TYR B 1 W216 I652 T653 G654 S657 D674 G675 W192 I628 T629 G630 S633 D650 G651 3.4.14.- 0004175,0004177,0006508,0008239,0009056,0042802,0042803,0051603,0070009 V5YM14 24827749 802 GEGMWVPQQLPEIAGPLKKAGLKLSPQQISDLTGDPMGAVVALGGCTASFVSPNGLVVTNHHCAYGAIQLNSTAENNLIKNGFNAPTTADEVSAGPNARVFVLDEITDVTKDAKAAIAAAGDDALARTKALEAFEKKLIADCEAEAGFRCRLYSFSGGNTYRLFKNLEIKDVRLAYAPPGSVGKFGGDIDNWMWPRHTGDFAFYRAYVGKDGKPAAFSKDNVPYQPKHWLKFADQPLGAGDFVMVAGYPGSTNRYALAAEFDNTAQWTYPTIARHYKNQIAMVEAAGKQNADIQVKYAATMAGWNNTSKNYDGQLEGFKRIDAAGQKLREEAAVLGWLKGQGAKGQPALDAHAKLLDLLEQSKATRDRDLTLALFNNTAMLGSATQLYRLSIEREKPNAERESGYQERDLPAIEGGLKQLERRYVAAMDRQLQEYWLNEYIKLPADQRVAAVDAWLGGNDAAAVKRALDRLAGTKLGSTEERLKWFAADRKAFEASNDPAIQYAVAVMPTLLKLEQERKTRAGENLAARPVYLQALADYKKSQGEFVYPDANLSLRITFGNVMGYAPKDGMEYTPFTTLEGVVAKETGQDPFDSPKALLDAVAAKRYGGLEDKRIGSVPVNYLSDLDITGGNSGSPVLDAHGKLVGLAFDGNWESVSSNWVFDPKMTRMIAVDGRYLRWIMQEVYPAPQLLKEMNVG 3won A 1.75 BS02 TYR A 1 H86 W216 I652 T653 G654 S657 D674 G675 H62 W192 I628 T629 G630 S633 D650 G651 3.4.14.- 0004175,0004177,0006508,0008239,0009056,0042802,0042803,0051603,0070009 V5YM14 24827749 802 GEGMWVPQQLPEIAGPLKKAGLKLSPQQISDLTGDPMGAVVALGGCTASFVSPNGLVVTNHHCAYGAIQLNSTAENNLIKNGFNAPTTADEVSAGPNARVFVLDEITDVTKDAKAAIAAAGDDALARTKALEAFEKKLIADCEAEAGFRCRLYSFSGGNTYRLFKNLEIKDVRLAYAPPGSVGKFGGDIDNWMWPRHTGDFAFYRAYVGKDGKPAAFSKDNVPYQPKHWLKFADQPLGAGDFVMVAGYPGSTNRYALAAEFDNTAQWTYPTIARHYKNQIAMVEAAGKQNADIQVKYAATMAGWNNTSKNYDGQLEGFKRIDAAGQKLREEAAVLGWLKGQGAKGQPALDAHAKLLDLLEQSKATRDRDLTLALFNNTAMLGSATQLYRLSIEREKPNAERESGYQERDLPAIEGGLKQLERRYVAAMDRQLQEYWLNEYIKLPADQRVAAVDAWLGGNDAAAVKRALDRLAGTKLGSTEERLKWFAADRKAFEASNDPAIQYAVAVMPTLLKLEQERKTRAGENLAARPVYLQALADYKKSQGEFVYPDANLSLRITFGNVMGYAPKDGMEYTPFTTLEGVVAKETGQDPFDSPKALLDAVAAKRYGGLEDKRIGSVPVNYLSDLDITGGNSGSPVLDAHGKLVGLAFDGNWESVSSNWVFDPKMTRMIAVDGRYLRWIMQEVYPAPQLLKEMNVG 3won B 1.75 BS02 TYR B 1 H86 W216 I652 T653 G654 S657 D674 G675 H62 W192 I628 T629 G630 S633 D650 G651 3.4.14.- 0004175,0004177,0006508,0008239,0009056,0042802,0042803,0051603,0070009 V5YM14 24827749 802 GEGMWVPQQLPEIAGPLKKAGLKLSPQQISDLTGDPMGAVVALGGCTASFVSPNGLVVTNHHCAYGAIQLNSTAENNLIKNGFNAPTTADEVSAGPNARVFVLDEITDVTKDAKAAIAAAGDDALARTKALEAFEKKLIADCEAEAGFRCRLYSFSGGNTYRLFKNLEIKDVRLAYAPPGSVGKFGGDIDNWMWPRHTGDFAFYRAYVGKDGKPAAFSKDNVPYQPKHWLKFADQPLGAGDFVMVAGYPGSTNRYALAAEFDNTAQWTYPTIARHYKNQIAMVEAAGKQNADIQVKYAATMAGWNNTSKNYDGQLEGFKRIDAAGQKLREEAAVLGWLKGQGAKGQPALDAHAKLLDLLEQSKATRDRDLTLALFNNTAMLGSATQLYRLSIEREKPNAERESGYQERDLPAIEGGLKQLERRYVAAMDRQLQEYWLNEYIKLPADQRVAAVDAWLGGNDAAAVKRALDRLAGTKLGSTEERLKWFAADRKAFEASNDPAIQYAVAVMPTLLKLEQERKTRAGENLAARPVYLQALADYKKSQGEFVYPDANLSLRITFGNVMGYAPKDGMEYTPFTTLEGVVAKETGQDPFDSPKALLDAVAAKRYGGLEDKRIGSVPVNYLSDLDITGGNSGSPVLDAHGKLVGLAFDGNWESVSSNWVFDPKMTRMIAVDGRYLRWIMQEVYPAPQLLKEMNVG 4d56 A 2.1 BS01 TYR A 1 D200 V201 E204 G273 G274 V298 G300 I306 D199 V200 E203 G272 G273 V297 G299 I305 T155 F175 T302 E303 K415 R420 T154 F174 T301 E302 K414 R419 ? 0000166,0005737,0005829,0031177,0043041,0044550,0046872 G0WVH3 26096082 1491 FKQSIHQLFETQVERTPEAVAVLSEQGQLTYEELNTKANQLAHYLRTLGVKSETLVGVCVDRSLEMVIGLLAILKAGGAYVPLDPTYPRERLTYMVQDAQISVLVTQTQWSNLISDYQGQVICLDSQWAKIASYSQENLVNTVNPENLAYVIYTSGSTGKPKGVMIEHQSLVNFTKLAIAQYQITTSDRTLQFVSISFDVAAEEIYVTLCSGATLILRTEEMISSIPSFVQKSQDWQITVWSLPTAYWHLLVNELVKSKIALPDSLRLVIIGGERVQPELVRMWFKNVGNFPELINVYGPTEGTIAVSLCRLSQLTESQRNRTEIPIGKSLGENISVYVLDETLKTVPPETPGEIYIGGTALARGYLNRPELTAQKFIQDPFSPSERLYKTGDLGRYLADGNLEYLGRVDHQVKINGFRVELGEIETVLLQHHQVAQAVVIDRRLVAYLVPHSTEENLTVTLQQFLKNKLPSYMIPATFVVL 4grs A 3.0 BS01 TYR A 1 M1 G40 I41 I42 G43 D45 M1 G40 I41 I42 G43 D45 2.5.1.54 0009058,0009073,0016832 Q8U0A9,Q9WYH8 23345433 401 MIVVLKPGSTEEDIRKVVKLAESYNLKCHISKGQERTVIGIIGDDRYVVADKFESLDCVESVVRVLKPYKLVSREFHPEDTVIDLGDVKIGNGYFTIIAGPCSIESRDQIMKVAEFLAEVGIKVLRGGAFKPRTSPYSFQGYGEKALRWMREAADEYGLVTVTEVMDTRHVELVAKYSDILQIGARNSQNFELLKEVGKVENPVLLKRGMGNTIQELLYSAEYIMAQGNENVILCERGIRTFETATRFTLDISAVPVVKELSHLPIIVDPSHPAGRRSLVIPLAKAAYAIGADGIMVEVHPEPEKALSDSQQQLTFDDFLQLLKELEALGWKG 4grs A 3.0 BS02 TYR A 2 S31 G33 E35 R36 V38 S31 G33 E35 R36 V38 2.5.1.54 0009058,0009073,0016832 Q8U0A9,Q9WYH8 23345433 402 MIVVLKPGSTEEDIRKVVKLAESYNLKCHISKGQERTVIGIIGDDRYVVADKFESLDCVESVVRVLKPYKLVSREFHPEDTVIDLGDVKIGNGYFTIIAGPCSIESRDQIMKVAEFLAEVGIKVLRGGAFKPRTSPYSFQGYGEKALRWMREAADEYGLVTVTEVMDTRHVELVAKYSDILQIGARNSQNFELLKEVGKVENPVLLKRGMGNTIQELLYSAEYIMAQGNENVILCERGIRTFETATRFTLDISAVPVVKELSHLPIIVDPSHPAGRRSLVIPLAKAAYAIGADGIMVEVHPEPEKALSDSQQQLTFDDFLQLLKELEALGWKG 4grs B 3.0 BS01 TYR B 1 M1 G40 I41 I42 G43 D45 M1 G40 I41 I42 G43 D45 2.5.1.54 0009058,0009073,0016832 Q8U0A9,Q9WYH8 23345433 401 MIVVLKPGSTEEDIRKVVKLAESYNLKCHISKGQERTVIGIIGDDRYVVADKFESLDCVESVVRVLKPYKLVSREFHPEDTVIDLGDVKIGNGYFTIIAGPCSIESRDQIMKVAEFLAEVGIKVLRGGAFKPRTSPYSFQGYGEKALRWMREAADEYGLVTVTEVMDTRHVELVAKYSDILQIGARNSQNFELLKEVGKVENPVLLKRGMGNTIQELLYSAEYIMAQGNENVILCERGIRTFETATRFTLDISAVPVVKELSHLPIIVDPSHPAGRRSLVIPLAKAAYAIGADGIMVEVHPEPEKALSDSQQQLTFDDFLQLLKELEALGWKG 4grs B 3.0 BS02 TYR D 1 S31 Q34 V38 S31 Q34 V38 2.5.1.54 0009058,0009073,0016832 Q8U0A9,Q9WYH8 23345433 401 MIVVLKPGSTEEDIRKVVKLAESYNLKCHISKGQERTVIGIIGDDRYVVADKFESLDCVESVVRVLKPYKLVSREFHPEDTVIDLGDVKIGNGYFTIIAGPCSIESRDQIMKVAEFLAEVGIKVLRGGAFKPRTSPYSFQGYGEKALRWMREAADEYGLVTVTEVMDTRHVELVAKYSDILQIGARNSQNFELLKEVGKVENPVLLKRGMGNTIQELLYSAEYIMAQGNENVILCERGIRTFETATRFTLDISAVPVVKELSHLPIIVDPSHPAGRRSLVIPLAKAAYAIGADGIMVEVHPEPEKALSDSQQQLTFDDFLQLLKELEALGWKG 4grs C 3.0 BS01 TYR A 1 S31 Q34 V38 S31 Q34 V38 2.5.1.54 0009058,0009073,0016832 Q8U0A9,Q9WYH8 23345433 401 MIVVLKPGSTEEDIRKVVKLAESYNLKCHISKGQERTVIGIIGDDRYVVADKFESLDCVESVVRVLKPYKLVSREFHPEDTVIDLGDVKIGNGYFTIIAGPCSIESRDQIMKVAEFLAEVGIKVLRGGAFKPRTSPYFQGYGEKALRWMREAADEYGLVTVTEVMDTRHVELVAKYSDILQIGARNSQNFELLKEVGKVENPVLLKRGMGNTIQELLYSAEYIMAQGNENVILCERGIRTFETATRFTLDISAVPVVKELSHLPIIVDPSHPAGRRSLVIPLAKAAYAIGADGIMVEVHPEPEKALSDSQQQLTFDDFLQLLKELEALGWKG 4grs C 3.0 BS02 TYR A 2 M1 I42 D45 L66 M1 I42 D45 L66 2.5.1.54 0009058,0009073,0016832 Q8U0A9,Q9WYH8 23345433 402 MIVVLKPGSTEEDIRKVVKLAESYNLKCHISKGQERTVIGIIGDDRYVVADKFESLDCVESVVRVLKPYKLVSREFHPEDTVIDLGDVKIGNGYFTIIAGPCSIESRDQIMKVAEFLAEVGIKVLRGGAFKPRTSPYFQGYGEKALRWMREAADEYGLVTVTEVMDTRHVELVAKYSDILQIGARNSQNFELLKEVGKVENPVLLKRGMGNTIQELLYSAEYIMAQGNENVILCERGIRTFETATRFTLDISAVPVVKELSHLPIIVDPSHPAGRRSLVIPLAKAAYAIGADGIMVEVHPEPEKALSDSQQQLTFDDFLQLLKELEALGWKG 4grs D 3.0 BS01 TYR B 1 S31 Q34 R36 V38 S31 Q34 R36 V38 2.5.1.54 0009058,0009073,0016832 Q8U0A9,Q9WYH8 23345433 401 MIVVLKPGSTEEDIRKVVKLAESYNLKCHISKGQERTVIGIIGDDRYVVADKFESLDCVESVVRVLKPYKLVSREFHPEDTVIDLGDVKIGNGYFTIIAGPCSIESRDQIMKVAEFLAEVGIKVLRGGAFKPRPYSFQGYGEKALRWMREAADEYGLVTVTEVMDTRHVELVAKYSDILQIGARNSQNFELLKEVGKVENPVLLKRGMGNTIQELLYSAEYIMAQGNENVILCERGIRTFETATRFTLDISAVPVVKELSHLPIIVDPSHPAGRRSLVIPLAKAAYAIGADGIMVEVHPEPEKALSDSQQQLTFDDFLQLLKELEALGWKG 4grs D 3.0 BS02 TYR D 1 M1 I41 I42 G43 V65 L66 M1 I41 I42 G43 V65 L66 2.5.1.54 0009058,0009073,0016832 Q8U0A9,Q9WYH8 23345433 401 MIVVLKPGSTEEDIRKVVKLAESYNLKCHISKGQERTVIGIIGDDRYVVADKFESLDCVESVVRVLKPYKLVSREFHPEDTVIDLGDVKIGNGYFTIIAGPCSIESRDQIMKVAEFLAEVGIKVLRGGAFKPRPYSFQGYGEKALRWMREAADEYGLVTVTEVMDTRHVELVAKYSDILQIGARNSQNFELLKEVGKVENPVLLKRGMGNTIQELLYSAEYIMAQGNENVILCERGIRTFETATRFTLDISAVPVVKELSHLPIIVDPSHPAGRRSLVIPLAKAAYAIGADGIMVEVHPEPEKALSDSQQQLTFDDFLQLLKELEALGWKG 4hso A 2.1 BS01 TYR A 1 Q153 L177 L181 S182 Q148 L172 L176 S177 2.5.1.54 0003849,0005737,0008652,0009058,0009073,0009423,0016740,0046872 Kd=22uM -logKd/Ki=4.66, Kd=22uM Q9K169 23754471 401 PTDDIKIKEVKELLPPIAHLYELPISKEASGLVHRTRQEISDLVHGRDKRLLVIIGPCSIHDPKAALEYAERLLKLRKQYENELLIVMRVYFEKPRTTVGWKGLINDPHLDGTFDINFGLRQARSLLLSLNNMGMPASTEFLDMITPQYYADLISWGAIGARTTESQVHRELASGLSCPVGFKNGTDGNLKIAIDAIGAASHSHHFLGVTKAGHSAIVHTGGNPDCHVILRGGKEPNYDAEHVSEAAEQLRAAGVTDKLMIDCSHANSRKDYTRQMEVAQDIAAQLEQDGGNIMGVMVESHLVEGRQDKPEVYGKSITDACIGWGATEELLALLAGANKKRMARA 4hso B 2.1 BS01 TYR A 1 D8 D9 D1 D2 2.5.1.54 0003849,0005737,0008652,0009058,0009073,0009423,0016740,0046872 Kd=22uM -logKd/Ki=4.66, Kd=22uM Q9K169 23754471 401 DDIKIKEVKELLPPIAHLYELPISKEASGLVHRTRQEISDLVHGRDKRLLVIIGPCSIHDPKAALEYAERLLKLRKQYENELLIVMRVYFEKPRTTVGWKGLINDPHLDGTFDINFGLRQARSLLLSLNNMGMPASTEFLDMITPQYYADLISWGAIGARTTESQVHRELASGLSCPVGFKNGTDGNLKIAIDAIGAASHSHHFLGVTKAGHSAIVHTGGNPDCHVILRGGKEPNYDAEHVSEAAEQLRAAGVTDKLMIDCSHANSRKDYTRQMEVAQDIAAQLEQDGGNIMGVMVESHLVEGRQDKPEVYGKSITDACIGWGATEELLALLAGANKKRMARA 4hso B 2.1 BS02 TYR B 1 Q153 A156 L177 L181 S182 Q146 A149 L170 L174 S175 2.5.1.54 0003849,0005737,0008652,0009058,0009073,0009423,0016740,0046872 Kd=22uM -logKd/Ki=4.66, Kd=22uM Q9K169 23754471 401 DDIKIKEVKELLPPIAHLYELPISKEASGLVHRTRQEISDLVHGRDKRLLVIIGPCSIHDPKAALEYAERLLKLRKQYENELLIVMRVYFEKPRTTVGWKGLINDPHLDGTFDINFGLRQARSLLLSLNNMGMPASTEFLDMITPQYYADLISWGAIGARTTESQVHRELASGLSCPVGFKNGTDGNLKIAIDAIGAASHSHHFLGVTKAGHSAIVHTGGNPDCHVILRGGKEPNYDAEHVSEAAEQLRAAGVTDKLMIDCSHANSRKDYTRQMEVAQDIAAQLEQDGGNIMGVMVESHLVEGRQDKPEVYGKSITDACIGWGATEELLALLAGANKKRMARA 4hso C 2.1 BS01 TYR C 1 Q153 L177 S182 Q149 L173 S178 2.5.1.54 0003849,0005737,0008652,0009058,0009073,0009423,0016740,0046872 Kd=22uM Q9K169 23754471 401 YPTDDIKIKEVKELLPPIAHLYELPISKEASGLVHRTRQEISDLVHGRDKRLLVIIGPCSIHDPKAALEYAERLLKLRKQYENELLIVMRVYFEKPRTTVGWKGLINDPHLDGTFDINFGLRQARSLLLSLNNMGMPASTEFLDMITPQYYADLISWGAIGARTTESQVHRELASGLSCPVGFKNGTDGNLKIAIDAIGAASHSHHFLGVTKAGHSAIVHTGGNPDCHVILRGGKEPNYDAEHVSEAAEQLRAAGVTDKLMIDCSHANSRKDYTRQMEVAQDIAAQLEQDGGNIMGVMVESHLVEGRQDKPEVYGKSITDACIGWGATEELLALLAGANKKRMARA 4hso C 2.1 BS04 TYR D 1 D8 D9 D4 D5 2.5.1.54 0003849,0005737,0008652,0009058,0009073,0009423,0016740,0046872 Kd=22uM Q9K169 23754471 401 YPTDDIKIKEVKELLPPIAHLYELPISKEASGLVHRTRQEISDLVHGRDKRLLVIIGPCSIHDPKAALEYAERLLKLRKQYENELLIVMRVYFEKPRTTVGWKGLINDPHLDGTFDINFGLRQARSLLLSLNNMGMPASTEFLDMITPQYYADLISWGAIGARTTESQVHRELASGLSCPVGFKNGTDGNLKIAIDAIGAASHSHHFLGVTKAGHSAIVHTGGNPDCHVILRGGKEPNYDAEHVSEAAEQLRAAGVTDKLMIDCSHANSRKDYTRQMEVAQDIAAQLEQDGGNIMGVMVESHLVEGRQDKPEVYGKSITDACIGWGATEELLALLAGANKKRMARA 4hso D 2.1 BS01 TYR D 1 Q153 L177 L181 S182 V214 Q149 L173 L177 S178 V210 2.5.1.54 0003849,0005737,0008652,0009058,0009073,0009423,0016740,0046872 Kd=22uM Q9K169 23754471 401 YPTDDIKIKEVKELLPPIAHLYELPISKEASGLVHRTRQEISDLVHGRDKRLLVIIGPCSIHDPKAALEYAERLLKLRKQYENELLIVMRVYFEKPRTTVGWKGLINDPHLDGTFDINFGLRQARSLLLSLNNMGMPASTEFLDMITPQYYADLISWGAIGARTTESQVHRELASGLSCPVGFKNGTDGNLKIAIDAIGAASHSHHFLGVTKAGHSAIVHTGGNPDCHVILRGGKEPNYDAEHVSEAAEQLRAAGVTDKLMIDCSHANSRKDYTRQMEVAQDIAAQLEQDGGNIMGVMVESHLVEGRQDKPEVYGKSITDACIGWGATEELLALLAGANKKRMARA 4i4t C 1.8 BS01 TYR B 1 Y262 D431 V435 Y262 D431 V435 3.6.5.- 0000226,0000278,0003924,0005200,0005525,0005737,0005829,0005856,0005874,0007017,0015630,0016787,0046872 P81947 23287720 506 MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGVDSV 4oel A 1.4 BS02 TYR A 1 G232 C234 E275 G146 C148 E189 Q228 C234 Q142 C148 3.4.14.1 0006508,0008234 -logKd/Ki=7.00, Ki=0.1uM P53634 22928782 502 DTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVLHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHT 4ojm X 1.95 BS01 TYR X 1 Y99 G101 D143 Y247 Q251 D254 Q273 Y68 G70 D112 Y208 Q212 D215 Q234 6.1.1.1 0000166,0004812,0004831,0005524,0006418,0006437 P12063 24520960 701 MLRREFGPKYTAKINEAEENWQARAEAIKKGKKQNTWDLFEERGYVKDTAGTKEHIAELMRTRRIGAYVGIDPTAPSLHVGHLLPLMPLFWMYLEGYKAFTLIGGSTAKIGDPTGSSSDATMNMTKIHYQLKKLWENVDTQMRARGYEADWARKRGIVNNNHWWNKQPMLEVLRRVGHALRIGPMLSRDTVKNKMTQGDGVSFAEFTYPIMQGWDWFELFYQQGVQMQIGGSDQYGNIISGLEVVKAARESEPDPQERKYVTPKTALDECVGFTVPLLTDSSGAKFGKSAGNAIWLDPYQTSVFDFYGYFVRRSDQEVENLLKLFTFMPISEITKTMEEHIKDPSKRVAQHTLAREVVTLVHGKQEASAAEDQHRMMYTGQM 4oud A 2.65 BS01 TYR A 1 Y37 G39 D41 L71 T76 D81 Y175 Q179 D182 Q201 Y34 G36 D38 L68 T73 D78 Y172 Q176 D179 Q198 T43 H48 H51 K85 R89 Q179 D200 T40 H45 H48 K82 R86 Q176 D197 6.1.1.1 0000166,0003723,0004812,0004831,0005524,0005737,0005829,0006412,0006418,0006437,0043039 A0A0H2UKY9 25607366 501 SNLIKQLQERGLVAQVTDEEALAERLAQGPIALYCGFDPTADSLHAGHLVPLLCLKRFQQAGHKPVALVGGATGLIGDPSFKAAERKLNTEETVQEWVDKIRKQVAPFLDFDCGENSAIAANNYDWFGNMNVLTFLRDIGKHFSVNQMINKEAVKQRLNREDQGISFTEFSYNLLQGYDFACLNKQYGVVLQIGGSDQWGNITSGIDLTRRLHQNQVFGLTVPLITKAGAVWLDPKKTSPYKFYQFAINAADADVYRWLKFGTFMSIEEINALEEEDKNSGKAPRAQYVFAEQVTRLVHGEEGLQAAKRITECLFSGSLSALSEADFEQLAQDGVPMVEMEKGADLMQALVDSELQPSRGQARKTIASNAITINGEKQSDPEYFFKEEDRLFGRFTLLRRGKKNYCLICWK 4p6r A 2.2 BS03 TYR A 1 H42 H60 H204 N205 H208 R209 V218 H39 H57 H201 N202 H205 R206 V215 H60 H69 H57 H66 1.14.18.1 0016491,0046872 B2ZB02 25074014 303 KYRVRKNVLHLTDTEKRDFVRTVLILKEKGIYDRYIAWHGAAGKFHTPPGSDRNAAHMSSAFLPWHREYLLRFERDLQSINPEVTLPYWEWETDAQMQDPSQSQIWSADFMGGNGNPIKDFIVDTGPFAAGRWTTIDEQGNPSGGLKRNFGATKEAPTLPTRDDVLNALKITQYDTPPWDMTSQNSFRNQLEGFINGPQLHNRVHRWVGGQMGVVPTAPNDPVFFLHHANVDRIWAVWQIIHRNQNYQPMKNGPFGQNFRDPMYPWNTTPEDVMNHRKLGYVYDIEL 4p6r B 2.2 BS03 TYR B 1 H42 H60 H204 N205 H208 R209 V218 H39 H57 H201 N202 H205 R206 V215 H60 H69 H57 H66 1.14.18.1 0016491,0046872 B2ZB02 25074014 303 KYRVRKNVLHLTDTEKRDFVRTVLILKEKGIYDRYIAWHGAAGKFHTPPGSDRNAAHMSSAFLPWHREYLLRFERDLQSINPEVTLPYWEWETDAQMQDPSQSQIWSADFMGGNGNPIKDFIVDTGPFAAGRWTTIDEQGNPSGGLKRNFGATKEAPTLPTRDDVLNALKITQYDTPPWDMTSQNSFRNQLEGFINGPQLHNRVHRWVGGQMGVVPTAPNDPVFFLHHANVDRIWAVWQIIHRNQNYQPMKNGPFGQNFRDPMYPWNTTPEDVMNHRKLGYVYDIE 4ppu A 2.3 BS01 TYR A 1 R150 Y174 R72 Y96 R92 R229 K240 F266 E270 T327 Q331 R14 R151 K162 F188 E192 T232 Q236 5.4.99.5 0004106,0009073,0046417 P42738 25160622 401 RVDESESLTLEGIRNSLIRQEDSIIFGLLERAKYCYNADTYDPTAFDMDGFNGSLVEYMVKGTEKLHAKVGRFKSPDEHPFFPDDLPEPMLPPLQYPKVLHFAADSININKKIWNMYFRDLVPRLVKKGDDGNYGSTAVCDAICLQCLSKRIHYGKFVAEAKFQASPEAYESAIKAQDKDALMDMLTFPTVEDAIKKRVEMKTRTYGQEVKVYKISPILVGDLYGDWIMPLTKEVQVEYLLRRLD 4qbt A 2.1 BS01 TYR A 1 Y39 G41 L72 A74 H77 V152 Y166 Q170 D173 Q188 Y36 G38 L69 A71 H74 V149 Y163 Q167 D170 Q185 6.1.1.1 0000166,0004812,0004831,0005524,0006418,0006437 P54577 25533949 506 APSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRVSYYENVIKAMLESIGVPLEKLKFIKGTDYQLSKEYTLDVYRLSSVVTQHDSKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGIDQRKIFTFAEKYLPALGYSKRVHLMNPMVPGLTGKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFAAEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYP 4r0t B 2.603 BS01 TYR B 1 H103 A104 R138 D175 H70 A71 R105 D142 3.1.3.16,3.1.3.48 Q9HXC7 25909591 301 TRSPAWAQAVDPSINLYRMSPTLYRSALPNAQSVALLQRLQVKTVVSFIKDDDRAWLGQAPVRVLSLPTHADRVDDAEVLSVLRQLQAAEREGPVLMHSKHGNNRTGLFAAMYRIVVQGWDKQAALEEMQHGGFGDEDDMRDASAYVRGADVDGLRLAMANG 4ts1 A 2.5 BS01 TYR A 1 Y34 G36 D78 Y169 Q173 D176 Q195 Y34 G36 D78 Y169 Q173 D176 Q195 T40 H45 H48 K82 R86 Q173 D194 K230 K233 T234 T40 H45 H48 K82 R86 Q173 D194 K228 K231 T232 6.1.1.1 0000166,0004812,0004831,0005524,0006418,0006437 Kd=11.6uM -logKd/Ki=4.94, Kd=11.6uM P00952 3612807 320 MDLLAELQWRGLVNQTTDEDGLRKLLNEERVTLYCGFDPTADSLHIGHLATILTMRRFQQAGHRPIALVGGATGLIGDPSGKKSERTLNAKETVEAWSARIKEQLGRFLDFEADGNPAKIKNNYDWIGPLDVITFLRDVGKHFSVNYMMAKESVQSRIETGISFTEFSYMMLQAYDFLRLYETEGCRLQIGGSDQWGNITAGLELIRKTKGRAFGLTIPLVTKADGTKFGKTESGTIWLDKEKTSPYEFYQFWINTDDRDVIRYLKYFTFLSKEEIEALEQELREAPEKRAAQKTLAEEVTKLVHGEEALRQAIRYA 4ts1 B 2.5 BS01 TYR B 1 Y34 G36 D78 Y169 Q173 D176 Q195 Y34 G36 D78 Y169 Q173 D176 Q195 T40 H45 H48 K82 R86 Q173 D194 K230 K233 T234 T40 H45 H48 K82 R86 Q173 D194 K228 K231 T232 6.1.1.1 0000166,0004812,0004831,0005524,0006418,0006437 Kd=11.6uM P00952 3612807 320 MDLLAELQWRGLVNQTTDEDGLRKLLNEERVTLYCGFDPTADSLHIGHLATILTMRRFQQAGHRPIALVGGATGLIGDPSGKKSERTLNAKETVEAWSARIKEQLGRFLDFEADGNPAKIKNNYDWIGPLDVITFLRDVGKHFSVNYMMAKESVQSRIETGISFTEFSYMMLQAYDFLRLYETEGCRLQIGGSDQWGNITAGLELIRKTKGRAFGLTIPLVTKADGTKFGKTESGTIWLDKEKTSPYEFYQFWINTDDRDVIRYLKYFTFLSKEEIEALEQELREAPEKRAAQKTLAEEVTKLVHGEEALR 4wji A 1.4 BS02 TYR A 1 S100 H123 A126 T128 R227 S99 H122 A125 T127 R226 1.3.1.- 0000166,0004665,0006571,0008977,0016491,0046872,0070403 Q92MG1 302 AQQFQTIALIGIGLIGSSIARDIREKQLAGTIVVTTRSEATLKRAGELGLGDRYTLSAAEAVEGADLVVVSVPVGASGAVAAEIAAHLKPGAIVTDVGSTKGSVIAQMAPHLPKDVHFVPGHPIAGTEHSGPDAGFAGLFRGRWCILTPPAGTDEEAVARLRLFWETLGSMVDEMDPKHHDKVLAIVSHLPHIIAYNIVGTADDLETVTESEVIKYSASGFRDFTRLAASDPTMWRDVCLHNKDAILEMLARFSEDLASLQRAIRWGDGDKLFDLFTRTRAIRRSIVQAGQDT 5ckv B 2.787 BS03 TYR B 1 P16 L18 E53 R256 P11 L13 E48 R251 2.5.1.54 0003849,0005515,0005829,0005886,0008652,0009073,0009274,0009423,0016740,0030145,0046872,0051260 O53512 26776476 508 MNWTVDIPSLPPLPTDLRTRLDAALAKPAAQQPTWPADQALAMRTVLESVPPVTVPSEIVRLQEQLAQVAKGEAFLLQGGDCAETFMDNTEPHIRGNVRALLQMAVVLTYGASMPVVKVARIAGQYAKPRSADIDALGLRSYRGDMINGFAPDAAAREHDPSRLVRAYANASAAMNLVRALTSSGLASLHLVHDWNREFVRTSPAGARYEALATEIDRGLRFMSACGVADRNLQTAEIYASHEALVLDYERAMLRLSDGEPQLFDLSAHTVWIGERTRQIDGAHIAFAQVIANPVGVKLGPNMTPELAVEYVERLDPHNKPGRLTLVSRMGNHKVRDLLPPIVEKVQATGHQVIWQCDPMHGNTHESSTGFKTRHFDRIVDEVQGFFEVHRALGTHPGGIHVEITGENVTECLGGAQDISETDLAGRYETACDPRLNTQQSLELAFLVAEMLRD 5ckx B 2.7 BS04 TYR B 1 P16 L18 R23 E53 R256 L259 P11 L13 R18 E48 R246 L249 2.5.1.54 0003849,0005515,0005829,0005886,0008652,0009073,0009274,0009423,0016740,0030145,0046872,0051260 O53512 26776476 509 MNWTVDIPILPPLPTDLRTRLDAALAKPAAQQPTWPADQALAMRTVLESVPPVTVPSEIVRLQEQLAQVAKGEAFLLQGGDCAETFMDNTEPHIRGNVRALLQMAVVLTYGASMPVVKVARIAGQYAKPRSADIDALGLRSYRGDMINGFAPDAAAREHDPSRLVRAYANASAAMNLVRALTSSGLASLHLVHDWNREFVRTSPAGARYEALATEIDRGLRFMSACGVATAEIYASHEALVLDYERAMLRLSDGDDGEPQLFDLSAHTVWIGERTRQIDGAHIAFAQVIANPVGVKLGPNMTPELAVEYVERLDPHNKPGRLTLVSRMGNHKVRDLLPPIVEKVQATGHQVIWQCDPMHGNTHESSTGFKTRHFDRIVDEVQGFFEVHRALGTHPGGIHVEITGENVTECLGGAQDISETDLAGRYETACDPRLNTQQSLELAFLVAEMLRD 5dcd A 2.31 BS03 TYR A 1 Q153 A156 L181 S182 S213 V223 Q150 A153 L178 S179 S210 V220 2.5.1.54 0003849,0005737,0008652,0009058,0009073,0009423,0016740,0046872 Q9K169 404 HYPTDDIKIKEVKELLPPIAHLYELPISKEASGLVHRTRQEISDLVHGRDKRLLVIIGPCSIHDPKAALEYAERLLKLRKQYENELLIVMRVYFEKPRTTVGWKGLINDPHLDGTFDINFGLRQARSLLLSLNNMGMPASTEFLDMITPQYYADLISWGAIGARTTESQVHRELASGLSCPVGFKNGTDGNLKIAIDAIGAASHSHHFLSVTKAGHSAIVHTGGNPDCHVILRGGKEPNYDAEHVSEAAEQLRAAGVTDKLMIDCSHANSRKDYTRQMEVAQDIAAQLEQDGGNIMGVMVESHLVEGRQDKPEVYGKSITDACIGWGATEELLALLAGANKKRMAR 5dcd B 2.31 BS03 TYR B 1 Q153 A156 L181 S182 S213 Q150 A153 L178 S179 S210 2.5.1.54 0003849,0005737,0008652,0009058,0009073,0009423,0016740,0046872 Q9K169 403 HYPTDDIKIKEVKELLPPIAHLYELPISKEASGLVHRTRQEISDLVHGRDKRLLVIIGPCSIHDPKAALEYAERLLKLRKQYENELLIVMRVYFEKPRTTVGWKGLINDPHLDGTFDINFGLRQARSLLLSLNNMGMPASTEFLDMITPQYYADLISWGAIGARTTESQVHRELASGLSCPVGFKNGTDGNLKIAIDAIGAASHSHHFLSVTKAGHSAIVHTGGNPDCHVILRGGKEPNYDAEHVSEAAEQLRAAGVTDKLMIDCSHANSRKDYTRQMEVAQDIAAQLEQDGGNIMGVMVESHLVEGRQDKPEVYGKSITDACIGWGATEELLALLAGANKKRMAR 5dcd C 2.31 BS03 TYR C 1 Q153 A156 L181 S182 S213 Q150 A153 L178 S179 S210 2.5.1.54 0003849,0005737,0008652,0009058,0009073,0009423,0016740,0046872 Q9K169 403 HYPTDDIKIKEVKELLPPIAHLYELPISKEASGLVHRTRQEISDLVHGRDKRLLVIIGPCSIHDPKAALEYAERLLKLRKQYENELLIVMRVYFEKPRTTVGWKGLINDPHLDGTFDINFGLRQARSLLLSLNNMGMPASTEFLDMITPQYYADLISWGAIGARTTESQVHRELASGLSCPVGFKNGTDGNLKIAIDAIGAASHSHHFLSVTKAGHSAIVHTGGNPDCHVILRGGKEPNYDAEHVSEAAEQLRAAGVTDKLMIDCSHANSRKDYTRQMEVAQDIAAQLEQDGGNIMGVMVESHLVEGRQDKPEVYGKSITDACIGWGATEELLALLAGANKKRMAR 5dcd D 2.31 BS03 TYR D 1 Q153 A156 L181 S182 S213 Q150 A153 L178 S179 S210 2.5.1.54 0003849,0005737,0008652,0009058,0009073,0009423,0016740,0046872 Q9K169 403 HYPTDDIKIKEVKELLPPIAHLYELPISKEASGLVHRTRQEISDLVHGRDKRLLVIIGPCSIHDPKAALEYAERLLKLRKQYENELLIVMRVYFEKPRTTVGWKGLINDPHLDGTFDINFGLRQARSLLLSLNNMGMPASTEFLDMITPQYYADLISWGAIGARTTESQVHRELASGLSCPVGFKNGTDGNLKIAIDAIGAASHSHHFLSVTKAGHSAIVHTGGNPDCHVILRGGKEPNYDAEHVSEAAEQLRAAGVTDKLMIDCSHANSRKDYTRQMEVAQDIAAQLEQDGGNIMGVMVESHLVEGRQDKPEVYGKSITDACIGWGATEELLALLAGANKKRMAR 5ihx A 2.298 BS01 TYR A 1 G129 L161 D171 Y275 Q279 D282 Q300 G57 L89 D99 Y203 Q207 D210 Q228 Q279 D299 Q207 D227 6.1.1.1 0000166,0004812,0004831,0005524,0006418,0006437 Q5BCM1 501 IEEGKKEWAQFAQEIKEGKRKSFVEHLEERGLIHDVVGDRDLLHRVFTEKRVGIYAGVDPTAPSMHVGHMLPFMVLAWGYVWGLPVTFLLGGATSRVGDPTGRLKGREQVHSSVRKANMASMHMQLKKLGASIERYGEKHGYKRQMIWRRTLTNNNVWWNKTPLLEVLRDLGAYIRIGPMLGRDTVKNRMERGDGMSFAEFTYPLMQAWDWWMLFKNGCQVQVGGSDQYGNILFGVGAVKTISKNTVLQEDNNPLSDDLDKPIGFTTPLLTTSNAIWLDKDMTSTFELYQFFVRTPDDAVERYLKMFTFLPIPEISKIMEEQNQDPSRRVAQHALAYEFVELIHGKDEADAVSMQHRQLF 5ijx A 2.63 BS01 TYR A 1 G116 D118 D158 Q266 D269 Q287 G67 D69 D109 Q211 D214 Q232 T120 H125 H128 R162 Q266 D286 K338 T71 H76 H79 R113 Q211 D231 K283 6.1.1.1 0000166,0004812,0004831,0005524,0006418,0006437 C5P455 501 RHITQQHLRRTAEAEEQWKLQAKEIEAGRKQSFLSFLEERGLVNSVVGQRDALDKLITRKRVGFYAGVDPTAPSLHIGHMLPFMILGWAYVHGLKAVFLIGGSTAKIGDPTGRMDGATRRANIANIHLQLKRLGFSFEKYGRKHGFEWEWAWRRALENNNTWWNKQSLKEVMEVLGTSLRLGPMLGRDYVKSRLASGEGMSIAEFCYPIMQGWDFWYLFQRKVQVQVGGSDQYGNILFGMDAIKGILKANPESEWAPKKDEDPDLANPYGITTPLLTTASGEKAVWLDKDMTSCYDLYQYFVRVADSDVERYLKMFTFVPTPAIKELMEEHAKDPSKRVAQHKLAREFVELIHGSLSAEQAAKDH 5jvo A 1.9 BS01 TYR A 1 A118 D122 T132 A134 A37 D41 T51 A53 ? 0003700,0006355,0034618,0051259 D9QA55 27233609 201 GTREKLRKMLDDLLVSVDHSGNIAVLRTPPGGAPFLASFIDRVGMEEVVGTIAGDDTVFVLARDPMTGQELGEFLSQRR 5jvo B 1.9 BS01 TYR B 1 S119 D122 T132 A134 S34 D37 T47 A49 ? 0003700,0006355,0034618,0051259 D9QA55 27233609 201 KLRKMLDDLLVSVDHSGNIAVLRTPPGGAPFLASFIDRVGMEEVVGTIAGDDTVFVLARDPMTGQELGEFLSQR 5m8p A 2.8 BS02 TYR A 1 R374 G389 T391 S394 R350 G365 T367 S370 1.14.18.- 0016491 P17643 28661582 502 QFPRQCATVEALRSGMCCPDLSPVSGPGTDRCGSSSGRGRCEAVTADSRPHSPQYPHDGRDDREVWPLRFFNRTCHCNGNFSGHNCGTCRPGWRGAACDQRVLIVRRNLLDLSKEEKNHFVRALDMAKRTTHPLFVIATRRSEEILGPDGNTPQFENISIYNYFVWTHYYSVKKTFLGVGQESFGEVDFSHEGPAFLTWHRYHLLRLEKDMQEMLQEPSFSLPYWNFATGKNVCDICTDDLMGSRSNFDSTLISPNSVFSQWRVVCDSLEDYDTLGTLCNSTEDGPIRRNPAGNVARPMVQRLPEPQDVAQCLEVGLFDTPPFYSNSTNSFRNTVEGYSDPTGKYDPAVRSLHNLAHLFLNGTGGQTHLSPNDPIFVLLHTFTDAVFDEWLRRYNADISTFPLENAPIGHNRQYNMVPFWPPVTNTEMFVTAPDNLGYTYEIQWPS 5m8p B 2.8 BS02 TYR B 1 Y362 R374 N378 H381 G389 T391 S394 Y338 R350 N354 H357 G365 T367 S370 1.14.18.- 0016491 P17643 28661582 501 QFPRQCATVEALRSGMCCPDLSPVSGPGTDRCGSSSGRGRCEAVTADSRPHSPQYPHDGRDDREVWPLRFFNRTCHCNGNFSGHNCGTCRPGWRGAACDQRVLIVRRNLLDLSKEEKNHFVRALDMAKRTTHPLFVIATRRSEEILGPDGNTPQFENISIYNYFVWTHYYSVKKTFLGVGQESFGEVDFSHEGPAFLTWHRYHLLRLEKDMQEMLQEPSFSLPYWNFATGKNVCDICTDDLMGSRSNFDSTLISPNSVFSQWRVVCDSLEDYDTLGTLCNSTEDGPIRRNPAGNVARPMVQRLPEPQDVAQCLEVGLFDTPPFYSNSTNSFRNTVEGYSDPTGKYDPAVRSLHNLAHLFLNGTGGQTHLSPNDPIFVLLHTFTDAVFDEWLRRYNADISTFPLENAPIGHNRQYNMVPFWPPVTNTEMFVTAPDNLGYTYEIQWPS 5m8p C 2.8 BS01 TYR C 1 Y362 R374 N378 H381 G389 T391 S394 Y338 R350 N354 H357 G365 T367 S370 1.14.18.- 0016491 P17643 28661582 502 QFPRQCATVEALRSGMCCPDLSPVSGPGTDRCGSSSGRGRCEAVTADSRPHSPQYPHDGRDDREVWPLRFFNRTCHCNGNFSGHNCGTCRPGWRGAACDQRVLIVRRNLLDLSKEEKNHFVRALDMAKRTTHPLFVIATRRSEEILGPDGNTPQFENISIYNYFVWTHYYSVKKTFLGVGQESFGEVDFSHEGPAFLTWHRYHLLRLEKDMQEMLQEPSFSLPYWNFATGKNVCDICTDDLMGSRSNFDSTLISPNSVFSQWRVVCDSLEDYDTLGTLCNSTEDGPIRRNPAGNVARPMVQRLPEPQDVAQCLEVGLFDTPPFYSNSTNSFRNTVEGYSDPTGKYDPAVRSLHNLAHLFLNGTGGQTHLSPNDPIFVLLHTFTDAVFDEWLRRYNADISTFPLENAPIGHNRQYNMVPFWPPVTNTEMFVTAPDNLGYTYEIQWPS 5m8p D 2.8 BS01 TYR D 1 Y362 R374 N378 H381 G389 Q390 T391 S394 Y338 R350 N354 H357 G365 Q366 T367 S370 1.14.18.- 0016491 P17643 28661582 501 QFPRQCATVEALRSGMCCPDLSPVSGPGTDRCGSSSGRGRCEAVTADSRPHSPQYPHDGRDDREVWPLRFFNRTCHCNGNFSGHNCGTCRPGWRGAACDQRVLIVRRNLLDLSKEEKNHFVRALDMAKRTTHPLFVIATRRSEEILGPDGNTPQFENISIYNYFVWTHYYSVKKTFLGVGQESFGEVDFSHEGPAFLTWHRYHLLRLEKDMQEMLQEPSFSLPYWNFATGKNVCDICTDDLMGSRSNFDSTLISPNSVFSQWRVVCDSLEDYDTLGTLCNSTEDGPIRRNPAGNVARPMVQRLPEPQDVAQCLEVGLFDTPPFYSNSTNSFRNTVEGYSDPTGKYDPAVRSLHNLAHLFLNGTGGQTHLSPNDPIFVLLHTFTDAVFDEWLRRYNADISTFPLENAPIGHNRQYNMVPFWPPVTNTEMFVTAPDNLGYTYEIQWPS 5t95 A 1.689 BS02 TYR A 1 S101 H124 G128 Q130 T131 Q184 D222 S93 H116 G120 Q122 T123 Q176 D214 1.3.1.13 0000166,0004665,0006571,0008977,0016491,0033730,0070403 ic50=5.9mM I1MYY4 28671678 302 SLKIGIVGFGNFGQFLAKTMIKQGHTLTATSRSDYSELCLQMGIHFFRDVSAFLTADIDVIVLCTSILSLSEVVGSMPLTSLKRPTLFVDVLSVKEHPRELLLRELPEDSDILCTHPMFGPQTAKNGWTDHTFMYDKVRIRDEVICSNFIQIFATEGCKMVQMSCEEHDRAAAKSQFITHTIGRTLGEMDIQSTPIDTKGFETLVKLKETTMRDSFDLYSGLFVYNRFARQELENLEHALHKVKETLMI 5t95 B 1.689 BS02 TYR B 1 S101 H124 G128 P129 Q130 T131 Q184 H188 D222 S94 H117 G121 P122 Q123 T124 Q177 H181 D215 1.3.1.13 0000166,0004665,0006571,0008977,0016491,0033730,0070403 ic50=5.9mM I1MYY4 28671678 302 QSLKIGIVGFGNFGQFLAKTMIKQGHTLTATSRSDYSELCLQMGIHFFRDVSAFLTADIDVIVLCTSILSLSEVVGSMPLTSLKRPTLFVDVLSVKEHPRELLLRELPEDSDILCTHPMFGPQTAKNGWTDHTFMYDKVRIRDEVICSNFIQIFATEGCKMVQMSCEEHDRAAAKSQFITHTIGRTLGEMDIQSTPIDTKGFETLVKLKETTMRDSFDLYSGLFVYNRFARQELENLEHALHKVKETLMI 5t9f A 1.994 BS02 TYR A 1 S101 H124 F127 G128 Q130 T131 Q184 H188 D222 S93 H116 F119 G120 Q122 T123 Q176 H180 D214 1.3.1.13 0000166,0004665,0006571,0008977,0016491,0033730,0070403 ic50=4.7mM I1MYY4 28671678 302 SLKIGIVGFGNFGQFLAKTMIKQGHTLTATSRSDYSELCLQMGIHFFRDVSAFLTADIDVIVLCTSILSLSEVVGSMPLTSLKRPTLFVDVLSVKEHPRELLLRELPEDSDILCTHPMFGPQTAKNGWTDHTFMYDKVRIRDEVICSNFIQIFATEGCKMVQMSCEEHDRAAAKSQFITHTIGRTLGEMDIQSTPIDTKGFETLVKLKETMMRDSFDLYSGLFVYNRFARQELENLEHALHKVKETLMI 5t9f B 1.994 BS02 TYR B 1 S101 H124 G128 P129 Q130 T131 Q184 D222 S94 H117 G121 P122 Q123 T124 Q177 D215 1.3.1.13 0000166,0004665,0006571,0008977,0016491,0033730,0070403 ic50=4.7mM I1MYY4 28671678 302 QSLKIGIVGFGNFGQFLAKTMIKQGHTLTATSRSDYSELCLQMGIHFFRDVSAFLTADIDVIVLCTSILSLSEVVGSMPLTSLKRPTLFVDVLSVKEHPRELLLRELPEDSDILCTHPMFGPQTAKNGWTDHTFMYDKVRIRDEVICSNFIQIFATEGCKMVQMSCEEHDRAAAKSQFITHTIGRTLGEMDIQSTPIDTKGFETLVKLKETMMRDSFDLYSGLFVYNRFARQELENLEHALHKVKETLMIQRT 5thh A 1.959 BS01 TYR A 1 Y39 G41 L72 A74 H77 V152 Y166 Q170 D173 Q188 Y36 G38 L69 A71 H74 V149 Y163 Q167 D170 Q185 6.1.1.1 0000166,0004812,0004831,0005524,0006418,0006437 P54577 28531329 401 APSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRVSYYENVIKAMLESIGVPLEKLKFIKGTDYQLSKEYTLDVYRLSSVVTQHDSKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGIDQRKIFTFAKKYLPALGYSKRVHLMNPMVPGLTGKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFAAEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYP 5uxn A 2.2 BS05 TYR A 1 A177 L179 Q223 E226 T227 A174 L176 Q220 E223 T224 2.5.1.54 0003849,0009073,0016740 Kd=23uM -logKd/Ki=4.64, Kd=23uM Q9I000 29608284 505 SWSPESWRAKPIQQQPEYPDAAHLARVEQTLAGYPPLVFAGEARELRRQFAEVTAGRAFLLQGGDCAESFAEFSAAKIRDTFKVLLQMAVVMTFAAGCPVVKVGRMAGQFAKPRSSGDETQNGVTLPAYRGDIVNGIGFDEKSRVPDPERLLQAYHQSTASLNLLRAFAQGGFADLHQVHRWNLDFIANSALAERYQQLADRIDETLAFMRACGLDSAPQLRETSFFTAHEALLLNYEEALTRRDSLTGEWYDCSAHMLWIGDRTRQIDGAHVEMLRGVGNPIGVKVGPSMDSEELIRLIDILNPDNDPGRLNLIVRMGADKVGDHLPRLIQAIQREGRQVLWSSDPMHGNTIKASSGYKTRDFARVLAEVRQFFEVHQAEGSYAGGIHIEMTGQNVTECIGGSRPITEDGLSDRYHTHCDPRLNADQSLELAFLIAETLKQVRR 5uyy A 2.6 BS01 TYR A 1 L314 D315 K316 A319 L320 E341 G348 L309 D310 K311 A314 L315 E336 G343 1.3.1.12 0000166,0004665,0006571,0008977,0016491,0046872,0070403 Q81P63 31750992 401 ESLEMRQMRKKVVLIGTGLIGGSLALAIKKDHDVTITGYDIFQEQVERAKELHVVDEIAVDLQHACEEAHLIVFASPVEETKKLLHKLASFHLREDVIVTDVGSTKGSIMNEAEALFSKEISFIGGHPMAGSHKTGVESAKAHLFENAFYILTPMHHVPNEHVEELKDWLKGTGSHFLVLNTEEHDYVTGIVSHFPHLIAAGLVKQVEKHAGDNPLIHQLAAGGFKDITRIASSSPKMWSDIVKQNREHLMVLLKEWISEMEDLYDTVSSGDAGEIQNYFADAKEYRDSLPVRKRGAIPAYHDLYVDVLDKVGALAHVTSILAREEISITNLQILEAREGLLGVLRISFQREEDRMKAKLALGEEKYQTYETI 5uyy A 2.6 BS02 TYR B 1 N152 I334 N147 I329 1.3.1.12 0000166,0004665,0006571,0008977,0016491,0046872,0070403 Q81P63 31750992 401 ESLEMRQMRKKVVLIGTGLIGGSLALAIKKDHDVTITGYDIFQEQVERAKELHVVDEIAVDLQHACEEAHLIVFASPVEETKKLLHKLASFHLREDVIVTDVGSTKGSIMNEAEALFSKEISFIGGHPMAGSHKTGVESAKAHLFENAFYILTPMHHVPNEHVEELKDWLKGTGSHFLVLNTEEHDYVTGIVSHFPHLIAAGLVKQVEKHAGDNPLIHQLAAGGFKDITRIASSSPKMWSDIVKQNREHLMVLLKEWISEMEDLYDTVSSGDAGEIQNYFADAKEYRDSLPVRKRGAIPAYHDLYVDVLDKVGALAHVTSILAREEISITNLQILEAREGLLGVLRISFQREEDRMKAKLALGEEKYQTYETI 5uyy B 2.6 BS01 TYR A 1 K139 S333 I334 K126 S320 I321 1.3.1.12 0000166,0004665,0006571,0008977,0016491,0046872,0070403 Q81P63 31750992 401 RKKVVLIGTGLIGGSLALAIKKDHDVTITGYDIFQEQVERAKELHVVDEIAVDLQHACEEAHLIVFASPVEETKKLLHKLASFHLREDVIVTDVGSTKGSIMNEAEALFSKEISFIGGHPMAGSHKTGVESAKAHLFENAFYILTPMHHVPNEHVEELKDWLKGTGSHFLVLNTEEHDYVTGIVSHFPHLIAAGLVKQVEKHAGDNPLIHQLAAGGFKDITRIASSSPKMWSDIVKQNREHLMVLLKEWISEMEDLYDTVSSGDAGEIQNYFADAKEYRDSLPVRKRGAIPAYHDLYVDVLDKVGALAHVTSILAREEISITNLQILEAREGLLGVLRISFQREEDRMKAKLALGEEKYQTYETI 5uyy B 2.6 BS02 TYR B 1 L314 D315 K316 A319 L320 I339 L301 D302 K303 A306 L307 I326 1.3.1.12 0000166,0004665,0006571,0008977,0016491,0046872,0070403 Q81P63 31750992 401 RKKVVLIGTGLIGGSLALAIKKDHDVTITGYDIFQEQVERAKELHVVDEIAVDLQHACEEAHLIVFASPVEETKKLLHKLASFHLREDVIVTDVGSTKGSIMNEAEALFSKEISFIGGHPMAGSHKTGVESAKAHLFENAFYILTPMHHVPNEHVEELKDWLKGTGSHFLVLNTEEHDYVTGIVSHFPHLIAAGLVKQVEKHAGDNPLIHQLAAGGFKDITRIASSSPKMWSDIVKQNREHLMVLLKEWISEMEDLYDTVSSGDAGEIQNYFADAKEYRDSLPVRKRGAIPAYHDLYVDVLDKVGALAHVTSILAREEISITNLQILEAREGLLGVLRISFQREEDRMKAKLALGEEKYQTYETI 5uyy C 2.6 BS01 TYR C 1 V313 L314 D315 K316 A319 L320 E341 G348 V308 L309 D310 K311 A314 L315 E336 G343 1.3.1.12 0000166,0004665,0006571,0008977,0016491,0046872,0070403 Q81P63 31750992 401 ESLEMRQMRKKVVLIGTGLIGGSLALAIKKDHDVTITGYDIFQEQVERAKELHVVDEIAVDLQHACEEAHLIVFASPVEETKKLLHKLASFHLREDVIVTDVGSTKGSIMNEAEALFSKEISFIGGHPMAGSHKTGVESAKAHLFENAFYILTPMHHVPNEHVEELKDWLKGTGSHFLVLNTEEHDYVTGIVSHFPHLIAAGLVKQVEKHAGDNPLIHQLAAGGFKDITRIASSSPKMWSDIVKQNREHLMVLLKEWISEMEDLYDTVSSGDAGEIQNYFADAKEYRDSLPVRKRGAIPAYHDLYVDVLDKVGALAHVTSILAREEISITNLQILEAREGLLGVLRISFQREEDRMKAKLALGEEKYQTYETI 5uyy C 2.6 BS02 TYR D 1 N152 I334 N147 I329 1.3.1.12 0000166,0004665,0006571,0008977,0016491,0046872,0070403 Q81P63 31750992 401 ESLEMRQMRKKVVLIGTGLIGGSLALAIKKDHDVTITGYDIFQEQVERAKELHVVDEIAVDLQHACEEAHLIVFASPVEETKKLLHKLASFHLREDVIVTDVGSTKGSIMNEAEALFSKEISFIGGHPMAGSHKTGVESAKAHLFENAFYILTPMHHVPNEHVEELKDWLKGTGSHFLVLNTEEHDYVTGIVSHFPHLIAAGLVKQVEKHAGDNPLIHQLAAGGFKDITRIASSSPKMWSDIVKQNREHLMVLLKEWISEMEDLYDTVSSGDAGEIQNYFADAKEYRDSLPVRKRGAIPAYHDLYVDVLDKVGALAHVTSILAREEISITNLQILEAREGLLGVLRISFQREEDRMKAKLALGEEKYQTYETI 5uyy D 2.6 BS01 TYR C 1 K139 S333 I334 K126 S320 I321 1.3.1.12 0000166,0004665,0006571,0008977,0016491,0046872,0070403 Q81P63 31750992 401 RKKVVLIGTGLIGGSLALAIKKDHDVTITGYDIFQEQVERAKELHVVDEIAVDLQHACEEAHLIVFASPVEETKKLLHKLASFHLREDVIVTDVGSTKGSIMNEAEALFSKEISFIGGHPMAGSHKTGVESAKAHLFENAFYILTPMHHVPNEHVEELKDWLKGTGSHFLVLNTEEHDYVTGIVSHFPHLIAAGLVKQVEKHAGDNPLIHQLAAGGFKDITRIASSSPKMWSDIVKQNREHLMVLLKEWISEMEDLYDTVSSGDAGEIQNYFADAKEYRDSLPVRKRGAIPAYHDLYVDVLDKVGALAHVTSILAREEISITNLQILEAREGLLGVLRISFQREEDRMKAKLALGEEKYQTYETI 5uyy D 2.6 BS02 TYR D 1 V313 L314 D315 K316 A319 L320 V300 L301 D302 K303 A306 L307 1.3.1.12 0000166,0004665,0006571,0008977,0016491,0046872,0070403 Q81P63 31750992 401 RKKVVLIGTGLIGGSLALAIKKDHDVTITGYDIFQEQVERAKELHVVDEIAVDLQHACEEAHLIVFASPVEETKKLLHKLASFHLREDVIVTDVGSTKGSIMNEAEALFSKEISFIGGHPMAGSHKTGVESAKAHLFENAFYILTPMHHVPNEHVEELKDWLKGTGSHFLVLNTEEHDYVTGIVSHFPHLIAAGLVKQVEKHAGDNPLIHQLAAGGFKDITRIASSSPKMWSDIVKQNREHLMVLLKEWISEMEDLYDTVSSGDAGEIQNYFADAKEYRDSLPVRKRGAIPAYHDLYVDVLDKVGALAHVTSILAREEISITNLQILEAREGLLGVLRISFQREEDRMKAKLALGEEKYQTYETI 6a8z A 2.045 BS02 TYR A 1 I149 E165 A301 E303 H322 E323 H326 E345 Y396 I113 E129 A265 E267 H286 E287 H290 E309 Y360 E303 H322 E323 H326 E345 E388 Y396 E267 H286 E287 H290 E309 E352 Y360 3.4.11.2 0006508,0008237,0008270,0046872 Q9RVZ5 31351924 502 QSVGDSIFPSLGQRGLDVQHYDLHLTVPRPGEPHLSGDVTLTVGAREPLSRIVLDLLGPRVSAAQWNGQRVRWVQTAQKVEVTLPRPLRPGETGRLRLIYAGTPELSGDGLPIRPGWQNEAGLSYSLSEPHGTRGFLPCNDHPSDPATFTVRVTVPASASAAASGLFTTQTERNGLKTLTFTQRVPVPTYALGLIVGPLERRTAPDVQLGTQTVHRRDIYAAGLPAGTTVPEGETARMLRVLSDWFGPYPDEVYGVALLPVRQLALETAGLTTMPATSNRERVRLHELAHQWFGDQVTLADWADTWLSEGFATYAELLWAESQGEDGQAMAADWYARLSVLPSRPLRATREEEIFDASAYFRGALALHALRLKVGDAAFGQFLHSYVKTFTGRPVSTTALLTLVKTQLGAEAEQTLRVWVEGRTLPPLPEPVGAP 6a8z B 2.045 BS02 TYR B 1 I149 E165 A301 E303 H322 H326 E345 Y396 I112 E128 A264 E266 H285 H289 E308 Y359 E303 H322 E323 H326 E345 E388 Y396 E266 H285 E286 H289 E308 E351 Y359 3.4.11.2 0006508,0008237,0008270,0046872 Q9RVZ5 31351924 502 QSVGDSIFPSLGQRGLDVQHYDLHLTVPRPGEPHLSGDVTLTVGAREPLSRIVLDLLGPRVSAAQWNGQRVRWVQTAQKVEVTLPRPLRPGETGRLRLIYAGTPELSPGLPIRPGWQNEAGLSYSLSEPHGTRGFLPCNDHPSDPATFTVRVTVPASASAAASGLFTTQTERNGLKTLTFTQRVPVPTYALGLIVGPLERRTAPDVQLGTQTVHRRDIYAAGLPAGTTVPEGETARMLRVLSDWFGPYPDEVYGVALLPVRQLALETAGLTTMPATSNRERVRLHELAHQWFGDQVTLADWADTWLSEGFATYAELLWAESQGEDGQAMAADWYARLSVLPSRPLRATREEEIFDASAYFRGALALHALRLKVGDAAFGQFLHSYVKTFTGRPVSTTALLTLVKTQLGAEAEQTLRVWVEGRTLPPLPEPV 6agm A 2.0 BS01 TYR A 1 P148 Q152 S181 F210 I213 L222 P145 Q149 S178 F207 I210 L219 2.5.1.54 0003849,0005737,0008652,0009058,0009073,0009423,0016740,0042802 P00888 30946901 601 DALNNVHITDEQVLMTPEQLKAAFPLSLQQEAQIADSRKSISDIIAGRDPRLLVVCGPCSIHDPETALEYARRFKALAAEVSDSLYLVMRVYFEKPRTTVGWKGLINDPHMDGSFDVEAGLQIARKLLLELVNMGLPLATEALDPNSPQYLGDLFSWSAIGARTTESQTHREMASGLSMPVGFKNGTDGSLATAINAMRAAAQPHRFVGINQAGQVALLQTQGNPDGHVILRGGKAPNYSPADVAQCEKEMEQAGLRPSLMVDCSHGNSNKDYRRQPAVAESVVAQIKDGNRSIIGLMIESNIHEGDACISWEMTDALLREIHQDLNGQLTARV 6agm B 2.0 BS01 TYR B 1 P148 P151 Q152 L180 S181 F210 G212 I213 L222 P145 P148 Q149 L177 S178 F207 G209 I210 L219 2.5.1.54 0003849,0005737,0008652,0009058,0009073,0009423,0016740,0042802 P00888 30946901 601 DALNNVHITDEQVLMTPEQLKAAFPLSLQQEAQIADSRKSISDIIAGRDPRLLVVCGPCSIHDPETALEYARRFKALAAEVSDSLYLVMRVYFEKPRTTVGWKGLINDPHMDGSFDVEAGLQIARKLLLELVNMGLPLATEALDPNSPQYLGDLFSWSAIGARTTESQTHREMASGLSMPVGFKNGTDGSLATAINAMRAAAQPHRFVGINQAGQVALLQTQGNPDGHVILRGGKAPNYSPADVAQCEKEMEQAGLRPSLMVDCSHGNSNKDYRRQPAVAESVVAQIKDGNRSIIGLMIESNIHEGDACISWEMTDALLREIHQDLNGQLTARV 6agm C 2.0 BS01 TYR C 1 P148 P151 Q152 L180 S181 F210 G212 I213 L222 P145 P148 Q149 L177 S178 F207 G209 I210 L219 2.5.1.54 0003849,0005737,0008652,0009058,0009073,0009423,0016740,0042802 P00888 30946901 601 DALNNVHITDEQVLMTPEQLKAAFPLSLQQEAQIADSRKSISDIIAGRDPRLLVVCGPCSIHDPETALEYARRFKALAAEVSDSLYLVMRVYFEKPRTTVGWKGLINDPHMDGSFDVEAGLQIARKLLLELVNMGLPLATEALDPNSPQYLGDLFSWSAIGARTTESQTHREMASGLSMPVGFKNGTDGSLATAINAMRAAAQPHRFVGINQAGQVALLQTQGNPDGHVILRGGKAPNYSPADVAQCEKEMEQAGLRPSLMVDCSHGNSNKDYRRQPAVAESVVAQIKDGNRSIIGLMIESNIHEGDACISWEMTDALLREIHQDLNGQLTARV 6agm D 2.0 BS01 TYR D 1 P148 P151 Q152 L180 S181 F210 G212 I213 L222 P145 P148 Q149 L177 S178 F207 G209 I210 L219 2.5.1.54 0003849,0005737,0008652,0009058,0009073,0009423,0016740,0042802 P00888 30946901 601 DALNNVHITDEQVLMTPEQLKAAFPLSLQQEAQIADSRKSISDIIAGRDPRLLVVCGPCSIHDPETALEYARRFKALAAEVSDSLYLVMRVYFEKPRTTVGWKGLINDPHMDGSFDVEAGLQIARKLLLELVNMGLPLATEALDPNSPQYLGDLFSWSAIGARTTESQTHREMASGLSMPVGFKNGTDGSLATAINAMRAAAQPHRFVGINQAGQVALLQTQGNPDGHVILRGGKAPNYSPADVAQCEKEMEQAGLRPSLMVDCSHGNSNKDYRRQPAVAESVVAQIKDGNRSIIGLMIESNIHEGDACISWEMTDALLREIHQDLNGQLTARV 6bqz A 2.3 BS01 TYR A 1 K46 G48 L80 Q182 D185 K39 G41 L73 Q170 D173 T52 H57 H60 R98 Q182 D199 T45 H50 H53 R86 Q170 D187 6.1.1.1 0000166,0003723,0004812,0004831,0005524,0005737,0005829,0006412,0006418,0006437,0043039,0046872 B0VML7 501 HHHLPAEEQLALIQRGTHEIISEEDLLKKLKENRPLKIKAGFDPTAPDLHLGHTVLINKLKTFQDLGHEVTFLIGDYTAMIGDPTRPPLSREQVEANAKTYQEQVFKILDPNKTKVRFNSEWFNQKSAADLIQLASQQTVSRMLERDDFTKRYNNHQPIAIHEFLYPLVQGYDSIALEADVELGGTDQTFNLLMGRTLQSRYGQESQVCITVPIL 6bqz B 2.3 BS01 TYR B 1 K46 G48 L80 Q182 D185 Q200 K38 G40 L72 Q170 D173 Q188 T52 H57 H60 R98 Q182 D199 T44 H49 H52 R86 Q170 D187 6.1.1.1 0000166,0003723,0004812,0004831,0005524,0005737,0005829,0006412,0006418,0006437,0043039,0046872 B0VML7 501 HHLPAEEQLALIQRGTHEIISEEDLLKKLKENRPLKIKAGFDPTAPDLHLGHTVLINKLKTFQDLGHEVTFLIGDYTAMIGDPTTRPPLSREQVEANAKTYQEQVFKILDPNKTKVRFNSEWFNQKSAADLIQLASQQTVSRMLERDDFTKRYNNHQPIAIHEFLYPLVQGYDSIALEADVELGGTDQTFNLLMGRTLQSRYGQESQVCITVPIL 6eem A 2.61001 BS02 TYR B 1 Y350 L371 Y332 L347 4.1.1.25 0004837,0005737,0006520,0016830,0016831,0019752,0030170 O82415 32371491 601 QNPLDPDEFRRQGHMIIDFLADYYKNVEKYPVRSQVEPGYLKKRLPESAPYNPESIETILEDVTNDIIPGLTHWQSPNYFAYFPSSGSIAGFLGEMLSTGFNVVGFNWMSSPAATELESIVMNWLGQMLTLPKSFLFSSDGGGGGVLQGTTCEAILCTLTAARDKMLNKIGRENINKLVVYASDQTHCALQKAAQIAGINPKNVRAIKTSKATNFGLSPNSLQSAILADIESGLVPLFLCATVGTTSSTAVDPIGPLCAVAKLYGIWVHIDAAYAGSACICPEFRHFIDGVEDADSFSLNAHKWFFTTLDCCCLWVKDSDSLVKALSTSPEYLKNQVIDYKDWQIALSRRFRSMKLWLVLRSYGVANLRTFLRSHVKMAKHFQGLIGMDNRFEIVVPRTFAMVCFRLKPTAIFKQKIVDNDYIEDQTNEVNVKLLESVNASGKIYMTHAVVGGVYMIRFAVGATLTEERHVTGAWKVVQEHTDAILG 6eem B 2.61001 BS02 TYR B 1 W90 Y98 F99 P100 H320 X321 W74 Y82 F83 P84 H302 X303 4.1.1.25 0004837,0005737,0006520,0016830,0016831,0019752,0030170 O82415 32371491 601 QNPLDPDEFRRQGHMIIDFLADYYKNVEKYPVRSQVEPGYLKKRLPESAPYNPESIETILEDVTNDIIPGLTHWQSPNYFAYFPSSGSIAGFLGEMLSTGFNVVGFNWMSSPAATELESIVMNWLGQMLTLPKSFLFSSDGGGGGVLQGTTCEAILCTLTAARDKMLNKIGRENINKLVVYASDQTHCALQKAAQIAGINPKNVRAIKTSKATNFGLSPNSLQSAILADIESGLVPLFLCATVGTTSSTAVDPIGPLCAVAKLYGIWVHIDAAYAGSACICPEFRHFIDGVEDADSFSLNAHKWFFTTLDCCCLWVKDSDSLVKALSTSPEYLKNKQVIDYKDWQIALSRRFRSMKLWLVLRSYGVANLRTFLRSHVKMAKHFQGLIGMDNRFEIVVPRTFAMVCFRLKPTAIFKQKIVDNDYIEDQTNEVNVKLLESVNASGKIYMTHAVVGGVYMIRFAVGATLTEERHVTGAWKVVQEHTDAILG 6eyv A 2.704 BS03 TYR A 1 H220 H375 D376 H379 M380 L416 G417 P419 S422 H180 H335 D336 H339 M340 L376 G377 P379 S382 ? 0046872 A0A0H2ZBG1 30030378 603 PQTPDEASLDLAATDGIRLGDRLRGLWDLRLVGGDAELPGLPREGLQLVLDVAPKGRGLIGYLDTPERLLAAEPPRFRVLGDLLGASSASIRWRLVDQASGSVAPTHDCSAVFDEVWAGDGTLSGRIQRLERSPLSPNEDFRFVAVKRHFPLAHERIVLNEKLLGWLVSPQHRLFHQLWHASRDKWHRLSEKQRNALRGVGWQPGPLDRERDARGPRKDRNASGIDFFFMHRHMLHTARSMQDLPSWERLPRPVVPLEYDRPGFIRYFDNPDGFSVPPAWVAVDDDEYSEWLHGLKSAEAYHANFLVWESQYQDPAYLAKLTLGQFGSELELGMHDWLHMRWASVTRDPSNGAPVMTDRFPADFAPRWFRPENDFLGDPFSSHVNPVFWSFHGWIDDRIEDWYRAHERFHPGEVQRREVEGIQWFAPGRWVEVGDPWLGPATHGLDVETMKLALRIIFS 6eyv B 2.704 BS03 TYR B 1 D376 H379 L416 G417 P419 S422 D335 H338 L375 G376 P378 S381 ? 0046872 A0A0H2ZBG1 30030378 902 PQTPDEASLDLAATDGIRLGDRLRGLWDLRLVGGDAELPGLPREGLQLVLDVAPKGRGLIGYLDTPERLLAAEPPRFRVLGDLLGASSASIRWRLVDQASGSVAPTHDCSAVFDEVWADGTLSGRIQRLERSPLSPNEDFRFVAVKRHFPLAHERIVLNEKLLGWLVSPQHRLFHQLWHASRDKWHRLSEKQRNALRGVGWQPGPLDRERDARGPRKDRNASGIDFFFMHRHMLHTARSMQDLPSWERLPRPVVPLEYDRPGFIRYFDNPDGFSVPPAWVAVDDDEYSEWLHGLKSAEAYHANFLVWESQYQDPAYLAKLTLGQFGSELELGMHDWLHMRWASVTRDPSNGAPVMTDRFPADFAPRWFRPENDFLGDPFSSHVNPVFWSFHGWIDDRIEDWYRAHERFHPGEVQRREVEGIQWFAPGRWVEVGDPWLGPATHGLDVETMKLALRIIF 6hjw A 2.5 BS01 TYR A 1 N211 A212 G213 S214 N130 A131 G132 S133 R92 R229 K240 Y266 E270 T320 Q324 R15 R148 K159 Y185 E189 T227 Q231 5.4.99.5 0004106,0005737,0008652,0009073,0009507,0016853,0042803,0046417 B4FNK8 30651637 401 ERVDRSEILTLDSIRQVLIRLEDSIIFGLLERAQFCYNADTYDSNAFHMGSLVEYMVRETEKLHAQVGRYKSPDEHPFFPEDLPEPRLPPMQYPRVLHPIADSININKEIWKMYFDELLPRLVKKGSDGNAGSSALCDTTCLQALSKRIHYGKFVAEAKFQESPEAYMPAIIAQDRDQLMHLLTYETVERAIEHRVEAKAKIFGQEVYKIVPSLVAELYSYRIMPLTKEVQIAYLLKRLD 6hjw A 2.5 BS02 TYR B 1 R79 V148 G149 R150 R2 V67 G68 R69 R92 R229 K240 Y266 E270 T320 Q324 R15 R148 K159 Y185 E189 T227 Q231 5.4.99.5 0004106,0005737,0008652,0009073,0009507,0016853,0042803,0046417 B4FNK8 30651637 401 ERVDRSEILTLDSIRQVLIRLEDSIIFGLLERAQFCYNADTYDSNAFHMGSLVEYMVRETEKLHAQVGRYKSPDEHPFFPEDLPEPRLPPMQYPRVLHPIADSININKEIWKMYFDELLPRLVKKGSDGNAGSSALCDTTCLQALSKRIHYGKFVAEAKFQESPEAYMPAIIAQDRDQLMHLLTYETVERAIEHRVEAKAKIFGQEVYKIVPSLVAELYSYRIMPLTKEVQIAYLLKRLD 6hjw B 2.5 BS01 TYR A 1 V148 R150 M172 V70 R72 M94 R92 R229 K240 Y266 E270 T320 Q324 R14 R151 K162 Y188 E192 T229 Q233 5.4.99.5 0004106,0005737,0008652,0009073,0009507,0016853,0042803,0046417 B4FNK8 30651637 401 RVDRSEILTLDSIRQVLIRLEDSIIFGLLERAQFCYNADTYDSNAFHMDGFGGSLVEYMVRETEKLHAQVGRYKSPDEHPFFPEDLPEPRLPPMQYPRVLHPIADSININKEIWKMYFDELLPRLVKKGSDGNAGSSALCDTTCLQALSKRIHYGKFVAEAKFQESPEAYMPAIIAQDRDQLMHLLTYETVERAIEHRVEAKAKIFGQEYKIVPSLVAELYSYRIMPLTKEVQIAYLLKRLDHHH 6hjw B 2.5 BS02 TYR B 1 N211 G213 S214 N133 G135 S136 R92 R229 K240 Y266 E270 T320 Q324 R14 R151 K162 Y188 E192 T229 Q233 5.4.99.5 0004106,0005737,0008652,0009073,0009507,0016853,0042803,0046417 B4FNK8 30651637 401 RVDRSEILTLDSIRQVLIRLEDSIIFGLLERAQFCYNADTYDSNAFHMDGFGGSLVEYMVRETEKLHAQVGRYKSPDEHPFFPEDLPEPRLPPMQYPRVLHPIADSININKEIWKMYFDELLPRLVKKGSDGNAGSSALCDTTCLQALSKRIHYGKFVAEAKFQESPEAYMPAIIAQDRDQLMHLLTYETVERAIEHRVEAKAKIFGQEYKIVPSLVAELYSYRIMPLTKEVQIAYLLKRLDHHH 6hni A 1.35 BS01 TYR A 1 H55 S113 T114 A133 S135 D158 N189 T237 D238 N239 A242 E263 Y279 H12 S70 T71 A90 S92 D115 N146 T194 D195 N196 A199 E220 Y236 ? Kd=94uM -logKd/Ki=4.03, Kd=94uM Q18A65 31420448 401 VKKIGITQLVEHPALDATRTGFVKALEKNGFKDGENIDIDFQNAQNDMPTTQSIASKFASDKKDLIFAISTPSAQAAFNATKDIPILITAVSDPVAAGLVKTLEKPGTNVSGTSDFVSVDKGLELLKIFAPKAKTIGVMYNTSEVNSKVQVDALKEYASKNGFKVVEKGITTSNEVNQGISSLVGKIDVLYVPTDNLVASSMPIVSKIATENKIPVIAAESGPVEKGALACQGINYEKLGYKTGEMAVKILNGESVSDMPVATSDDTDIIVNEDILKALGMEKPSNENISYVKTK 6iff A 1.83 BS02 TYR A 1 I149 E165 A301 E303 H322 H326 E345 F391 Y396 I111 E127 A263 E265 H284 H288 E307 F353 Y358 E303 H322 A323 H326 E345 E388 Y396 E265 H284 A285 H288 E307 E350 Y358 3.4.11.2 0006508,0008237,0008270,0046872 Q9RVZ5 31923495 502 QSVGDSIFPSLGQRGLDVQHYDLHLTVPRPGEPHLSGDVTLTVGAREPLSRIVLDLLGPRVSAAQWNGQRVRWVQTAQKVEVTLPRPLRPGETGRLRLIYAGTPELSGLPIRPGWQNEAGLSYSLSEPHGTRGFLPCNDHPSDPATFTVRVTVPASASAAASGLFTTQTERNGLKTLTFTQRVPVPTYALGLIVGPLERRTAPDVQLGTQTVHRRDIYAAGLPAGTTVPEGETARMLRVLSDWFGPYPDEVYGVALLPVRQLALETAGLTTMPATSNRERVRLHALAHQWFGDQVTLADWADTWLSEGFATYAELLWAESQGEDGQAMAADWYARLSVLPSRPLRATREEEIFDASAYFRGALALHALRLKVGDAAFGQFLHSYVKTFTGRPVSTTALLTLVKTQLGAEAEQTLRVWVEGRTLPPLPEP 6iff B 1.83 BS02 TYR B 1 I149 E165 A301 E303 H322 H326 E345 Y396 I111 E127 A263 E265 H284 H288 E307 Y358 E303 H322 A323 H326 E345 E388 Y396 E265 H284 A285 H288 E307 E350 Y358 3.4.11.2 0006508,0008237,0008270,0046872 Q9RVZ5 31923495 502 QSVGDSIFPSLGQRGLDVQHYDLHLTVPRPGEPHLSGDVTLTVGAREPLSRIVLDLLGPRVSAAQWNGQRVRWVQTAQKVEVTLPRPLRPGETGRLRLIYAGTPELSGLPIRPGWQNEAGLSYSLSEPHGTRGFLPCNDHPSDPATFTVRVTVPASASAAASGLFTTQTERNGLKTLTFTQRVPVPTYALGLIVGPLERRTAPDVQLGTQTVHRRDIYAAGLPAGTTVPEGETARMLRVLSDWFGPYPDEVYGVALLPVRQLALETAGLTTMPATSNRERVRLHALAHQWFGDQVTLADWADTWLSEGFATYAELLWAESQGEDGQAMAADWYARLSVLPSRPLRATREEEIFDASAYFRGALALHALRLKVGDAAFGQFLHSYVKTFTGRPVSTTALLTLVKTQLGAEAEQTLRVWVEGRTLPPLPEP 6ju7 A 1.42 BS01 TYR A 1 H328 N329 H332 N333 M356 S357 V359 H312 N313 H316 N317 M340 S341 V343 1.14.18.1 0016491 A0A1S9DK56 32356371 1601 SPYLITGIPKDPKHPLPIRKDIDDWYLEQTSAGSNRIQLTLFVEALTVIQNRPLNDQLSYFRLAGIHGAPWTEWDGVPGGQKDSKGNPTGFAVHNNYTFPTWHRVYVTLYEQVIYEAMLDFIKQNVPQNGKADWENEAKQWRLPYWDFARFARHGTQGDELRLPILVTMPMVKVLVPGQPGKQLSKPNPLYRFQMQTLMGTLERPYAITSQKTEEHGWSFDLPFDKCQSTTKYGLLENYNADVWADGGQNWLRANLALNEHPWYQNLDGWDSVPTLQDMTFRLLTTGGLNWGEFSSTRYDDKKNWMNLEAIHNNVHNWVGGFMFSRPGRHDLKLWGAGHMSSVPVAAYDPIFWLHHCNIDRLTAIWQTVNSGSWFNDDKSKVSKDDDLRPFHRFCEKTRKVVFFRSDDVKDWRSLNYDYAITKDASRIRKEISDLYG 6ju7 B 1.42 BS01 TYR B 1 H328 N329 H332 N333 M356 S357 V359 H314 N315 H318 N319 M342 S343 V345 1.14.18.1 0016491 A0A1S9DK56 32356371 2601 GSPYLITGIPKDPKHPLPIRKDIDDWYLEQTSAGSNRIQLTLFVEALTVIQNRPLNDQLSYFRLAGIHGAPWTEWDGVPGGQKDSKGNPTGFAVHNNYTFPTWHRVYVTLYEQVIYEAMLDFIKQNVPQNGKADWENEAKQWRLPYWDFARFARHGHDNDELRLPILVTMPMVKVLVPGQPGKQLSKPNPLYRFQMQTLMGTLERPYAITSQKTEEHGWSFDLPFDKCQSTTKYGLLENYNADVWADGGQNWLRANLALNEHPWYQNLDGWDSVPTLQDMTFRLLTTGGLNWGEFSSTRYDQAPKNWMNLEAIHNNVHNWVGGFMFSRPGRHDLKLWGAGHMSSVPVAAYDPIFWLHHCNIDRLTAIWQTVNSGSWFNDDKSKVSKDDDLRPFHRFCTRKVVFFRSDDVKDWRSLNYDYAITKDASRIRKEISDLYGQ 6ju9 A 1.42 BS01 TYR A 1 N329 H332 N333 M356 S357 V359 N311 H314 N315 M338 S339 V341 1.14.18.1 0016491 A0A1S9DK56 32356371 501 SPYLITGIPKDPKHPLPIRKDIDDWYLEQTSSNRIQLTLFVEALTVIQNRPLNDQLSYFRLAGIHGAPWTEWDGVPGGQKDSKGNPTGFAVHNNYTFPTWHRVYVTLYEQVIYEAMLDFIKQNVPQNGKADWENEAKQWRLPYWDFARFARHGGDELRLPILVTMPMVKVLVPGQPGKQLSKPNPLYRFQMQTLMGTLERPYAITSQKTEEHGWSFDLPFDKCQSTTKYGLLENYNADVWADGGQNWLRANLALNEHPWYQNLDGWDSVPTLQDMTFRLLTTGGLNWGEFSSTRYDDKKEKNWMNLEAIHNNVHNWVGGFMFSRPGRHDLKLWGAGHMSSVPVAAYDPIFWLHHCNIDRLTAIWQTVNSGSWFNDDKSKVSKDDDLRPFHRFCEKTRKVVFFRSDDVKDWRSLNYDYAITKDASRIRKEISDLYG 6ju9 B 1.42 BS01 TYR B 1 H328 N329 H332 N333 M356 S357 V359 H310 N311 H314 N315 M338 S339 V341 1.14.18.1 0016491 A0A1S9DK56 32356371 501 GGSPYLITGIPKDPKHPLPIRKDIDDWYLEQTSAGSNRIQLTLFVEALTVIQNRPLNDQLSYFRLAGIHGAPWTEWDGVPGGQKDSKGNPTGFAVHNNYTFPTWHRVYVTLYEQVIYEAMLDFIKQNVPQNGKADWENEAKQWRLPYWDFARFARDELRLPILVTMPMVKVLVPGQPGKQLSKPNPLYRFQMQTLMGTLERPYAITSQKTEEHGWSFDLPFDKCQSTTKYGLLENYNADVWADGGQNWLRANLALNEHPWYQNLDGWDSVPTLQDMTFRLLTTGGLNWGEFSSTRYDQAPKNWMNLEAIHNNVHNWVGGFMFSRPGRHDLKLWGAGHMSSVPVAAYDPIFWLHHCNIDRLTAIWQTVNSGSWFNDDKSKVSKDDDLRPFHRFCTRKVVFFRSDDVKDWRSLNYDYAITKDASRIRKEISDLYGQ 6l1o B 1.9 BS01 TYR B 1 F17 Q39 G40 K104 Y128 E130 Y325 R367 F17 Q39 G40 K104 Y128 E130 Y325 R367 2.6.1.- 0003824,0005737,0008483,0009058,0017000,0030170 P39643 32134000 401 MEITPSDVIKTLPRQEFSLVFQKVKEMEKTGAHIINLGQGNPDLPTPPHIVEALREASLNPSFHGYGPFRGYPFLKEAIAAFYKREYGVTINPETEVALFGGGKAGLYVLTQCLLNPGDIALVPNPGYPEYLSGITMARAELYEMPLYEENGYLPDFEKIDPAVLEKAKLMFLNYPNNPTGAVADAAFYAKAAAFAKEHNIHLIHDFAYGAFEFDQKPASFLEAEDAKTVGAELYSFSKTFNMAGWRMAFAVGNEKIIQAVNEFQDHVFVGMFGGLQQAASAALSGDPEHTESLKRIYKERIDFFTALCEKELGWKMEKPKGTFYVWAEIPNTFETSHQFSDYLLEHAHVVVTPGEIFGSNGKRHVRISMVSKQEDLREFVTRIQKLNLPFG 6otj A 2.85 BS01 TYR A 1 Y34 G36 D38 L68 D78 Y171 Q175 D178 Q197 Y34 G36 D38 L68 D78 Y171 Q175 D178 Q197 T40 H45 H48 K82 R86 Q175 D196 K231 K234 T235 T40 H45 H48 K82 R86 Q175 D196 K231 K234 T235 6.1.1.1 0000166,0003723,0004812,0004831,0005524,0005737,0005829,0006412,0006418,0006437,0043039 B4RP13 501 MSVIQDLQSRGLIAQTTDIEALDALLNEQKIALYCGFDPTADSLHIGHLLPVLALRRFQQAGHTPIALVGGATGMIGDPSFKAAERSLNSAETVAGWVGSIRSQLTPFLSFEGGNAAIMANNADWFGSMNCLDFLRDIGKHFSVNAMLNKESVKQRIDRDGAGISFTEFAYSLLQGYDFAELNKRHGAVLEIGGSDQWGNITAGIDLTRRLNQKQVFGLTLPLVTKSDGTKFGKTEGGAVWLNAKKTSPYQFYQFWLKVADADVYKFLKYFTFLSIEEIGVVEAKDKASGSKPEAQRILAEEMTRLIHGEEALAAAQRISESLFAEDQSRLTESDFEQLALDGLPAFEVSDGINAVEALVKTGLAASNKEARGFVNAKAVLLNGKPAEANNPNHPDDAYLLIGEYKRFGKYTILRRGKRNHALLVWK 6otj B 2.85 BS01 TYR B 1 Y34 G36 D38 L68 T73 Y171 Q175 D178 Q197 Y38 G40 D42 L72 T77 Y175 Q179 D182 Q201 T40 H45 H48 K82 R86 Q175 D196 K231 K234 T235 T44 H49 H52 K86 R90 Q179 D200 K235 K238 T239 6.1.1.1 0000166,0003723,0004812,0004831,0005524,0005737,0005829,0006412,0006418,0006437,0043039 B4RP13 501 HHHHMSVIQDLQSRGLIAQTTDIEALDALLNEQKIALYCGFDPTADSLHIGHLLPVLALRRFQQAGHTPIALVGGATGMIGDPSFKAAERSLNSAETVAGWVGSIRSQLTPFLSFEGGNAAIMANNADWFGSMNCLDFLRDIGKHFSVNAMLNKESVKQRIDRDGAGISFTEFAYSLLQGYDFAELNKRHGAVLEIGGSDQWGNITAGIDLTRRLNQKQVFGLTLPLVTKSDGTKFGKTEGGAVWLNAKKTSPYQFYQFWLKVADADVYKFLKYFTFLSIEEIGVVEAKDKASGSKPEAQRILAEEMTRLIHGEEALAAAQRISESLFAEDQSRLTESDFEQLALDGLPAFEVSDGINAVEALVKTGLAASNKEARGFVNAKAVLLNGKPAEANNPNHPDDAYLLIGEYKRFGKYTILRRGKRNHALLVWK 6pz0 A 1.8 BS02 TYR A 1 E68 Y72 L83 K92 E67 Y71 L82 K91 1.21.1.1 0006570,0010181,0016491,0072545,0140616 B9K712 34748729 302 KMLYDLAKKRKTVRRFKKEKPPLEDLIYSLKVANEAPSGMNAQPWRFLIVEDEKLKGQIRRVCERSEKTFYENVRGRLKEWLDEKRFTWRKPFLKEAPYLLLVFSEKSAPYSRESVWLAVGYLLLALEEKGLGSVPYTPPDFREVEKLVNTPSELRLEVILPVGYPDDPKPKYPRNEVIVRYNTF 6pz0 B 1.8 BS02 TYR A 1 G40 M41 Y112 G38 M39 Y110 1.21.1.1 0006570,0010181,0016491,0072545,0140616 B9K712 34748729 302 MLYDLAKKRKTVRRFKKEKPPLEDLIYSLKVANEAPSGMNAQPWRFLIVEDEKLKGQIRRVCERSEKTFYENVRGRLKEWLDEKRFTWRKPFLKEAPYLLLVFSEKSAPYSRESVWLAVGYLLLALEEKGLGSVPYTPPDFREVEKLVNTPSELRLEVILPVGYPDDPKPKYPRNEVIVRYNTF 6pz0 B 1.8 BS04 TYR B 1 E68 Y72 K92 E66 Y70 K90 1.21.1.1 0006570,0010181,0016491,0072545,0140616 B9K712 34748729 302 MLYDLAKKRKTVRRFKKEKPPLEDLIYSLKVANEAPSGMNAQPWRFLIVEDEKLKGQIRRVCERSEKTFYENVRGRLKEWLDEKRFTWRKPFLKEAPYLLLVFSEKSAPYSRESVWLAVGYLLLALEEKGLGSVPYTPPDFREVEKLVNTPSELRLEVILPVGYPDDPKPKYPRNEVIVRYNTF 6u60 A 2.1 BS01 TYR A 1 N152 I334 N139 I321 1.3.1.12 0000166,0004665,0006571,0008977,0016491,0046872,0070403 Q81P63 31750992 401 RKKVVLIGTGLIGGSLALAIKKDHDVTITGYDIFQEQVERAKELHVVDEIAVDLQHACEEAHLIVFASPVEETKKLLHKLASFHLREDVIVTDVGSTKGSIMNEAEALFSKEISFIGGHPMAGSHKTGVESAKAHLFENAFYILTPMHHVPNEHVEELKDWLKGTGSHFLVLNTEEHDYVTGIVSHFPHLIAAGLVKQVEKHAGDNPLIHQLAAGGFKDITRIASSSPKMWSDIVKQNREHLMVLLKEWISEMEDLYDTVSSGDAGEIQNYFADAKEYRDSLPVRKRGAIPAYHDLYVDVLDKVGALAHVTSILAREEISITNLQILEAREGLLGVLRISFQREEDRMKAKLALGEEKYQTYETI 6u60 A 2.1 BS02 TYR A 2 V313 L314 D315 K316 A319 L320 I339 E341 V300 L301 D302 K303 A306 L307 I326 E328 1.3.1.12 0000166,0004665,0006571,0008977,0016491,0046872,0070403 Q81P63 31750992 402 RKKVVLIGTGLIGGSLALAIKKDHDVTITGYDIFQEQVERAKELHVVDEIAVDLQHACEEAHLIVFASPVEETKKLLHKLASFHLREDVIVTDVGSTKGSIMNEAEALFSKEISFIGGHPMAGSHKTGVESAKAHLFENAFYILTPMHHVPNEHVEELKDWLKGTGSHFLVLNTEEHDYVTGIVSHFPHLIAAGLVKQVEKHAGDNPLIHQLAAGGFKDITRIASSSPKMWSDIVKQNREHLMVLLKEWISEMEDLYDTVSSGDAGEIQNYFADAKEYRDSLPVRKRGAIPAYHDLYVDVLDKVGALAHVTSILAREEISITNLQILEAREGLLGVLRISFQREEDRMKAKLALGEEKYQTYETI 6u60 B 2.1 BS01 TYR A 1 L314 D315 K316 A319 L320 L301 D302 K303 A306 L307 1.3.1.12 0000166,0004665,0006571,0008977,0016491,0046872,0070403 Q81P63 31750992 401 RKKVVLIGTGLIGGSLALAIKKDHDVTITGYDIFQEQVERAKELHVVDEIAVDLQHACEEAHLIVFASPVEETKKLLHKLASFHLREDVIVTDVGSTKGSIMNEAEALFSKEISFIGGHPMAGSHKTGVESAKAHLFENAFYILTPMHHVPNEHVEELKDWLKGTGSHFLVLNTEEHDYVTGIVSHFPHLIAAGLVKQVEKHAGDNPLIHQLAAGGFKDITRIASSSPKMWSDIVKQNREHLMVLLKEWISEMEDLYDTVSSGDAGEIQNYFADAKEYRDSLPVRKRGAIPAYHDLYVDVLDKVGALAHVTSILAREEISITNLQILEAREGLLGVLRISFQREEDRMKAKLALGEEKYQTYETI 6u60 B 2.1 BS02 TYR A 2 K139 S333 I334 K126 S320 I321 1.3.1.12 0000166,0004665,0006571,0008977,0016491,0046872,0070403 Q81P63 31750992 402 RKKVVLIGTGLIGGSLALAIKKDHDVTITGYDIFQEQVERAKELHVVDEIAVDLQHACEEAHLIVFASPVEETKKLLHKLASFHLREDVIVTDVGSTKGSIMNEAEALFSKEISFIGGHPMAGSHKTGVESAKAHLFENAFYILTPMHHVPNEHVEELKDWLKGTGSHFLVLNTEEHDYVTGIVSHFPHLIAAGLVKQVEKHAGDNPLIHQLAAGGFKDITRIASSSPKMWSDIVKQNREHLMVLLKEWISEMEDLYDTVSSGDAGEIQNYFADAKEYRDSLPVRKRGAIPAYHDLYVDVLDKVGALAHVTSILAREEISITNLQILEAREGLLGVLRISFQREEDRMKAKLALGEEKYQTYETI 6wjo A 1.693 BS01 TYR A 1 A118 S119 D122 T132 I133 A37 S38 D41 T51 I52 ? 0003700,0006355,0034618,0051259 D9QA55 32156582 201 GTREKLRKMLDDLLVSVDHSGNIAVLRTPPGGAPFLASFIDRVGMEEVVGTIAGDDTVFVLARDPMTGQELGEFLSQRR 6wjo B 1.693 BS01 TYR B 1 P115 A118 S119 D122 T132 I133 A134 P32 A35 S36 D39 T49 I50 A51 ? 0003700,0006355,0034618,0051259 D9QA55 32156582 201 REKLRKMLDDLLVSVDHSGNIAVLRTPPGGAPFLASFIDRVGMEEVVGTIAGDDTVFVLARDPMTGQELGEFLSQR 6yjy A 1.67 BS03 TYR A 1 Y299 I303 P324 F325 Y267 I271 P292 F293 2.3.2.5 0005515,0005576,0008270,0016603,0016746,0017186,0035580,0036211,0046872,0070062,1904724,1904813 Q16769 32551535 413 GPAWPEEKNYHQPAILNSSALRQIAEGTSISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSFSNIISTLNPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLSLKTVSDSKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHGMDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYGGVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLHL 6yjy B 1.67 BS04 TYR B 1 V302 Q304 V270 Q272 2.3.2.5 0005515,0005576,0008270,0016603,0016746,0017186,0035580,0036211,0046872,0070062,1904724,1904813 Q16769 32551535 413 GPAWPEEKNYHQPAILNSSALRQIAEGTSISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSFSNIISTLNPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLSLKTVSDSKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHGMDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYGGVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLHL 6yjy B 1.67 BS06 TYR B 2 V302 Q304 V270 Q272 2.3.2.5 0005515,0005576,0008270,0016603,0016746,0017186,0035580,0036211,0046872,0070062,1904724,1904813 Q16769 32551535 416 GPAWPEEKNYHQPAILNSSALRQIAEGTSISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSFSNIISTLNPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLSLKTVSDSKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHGMDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYGGVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLHL 6yu7 A 2.3 BS01 TYR A 1 S25 A26 G28 G30 Y108 F230 T231 S233 M236 L328 S18 A19 G21 G23 Y101 F223 T224 S226 M229 L321 ? 0016020 Q9KDT3 33155685 506 GREQWASRLGFILAAMGSAVGLGNIWRFSYVTGENGGAAFLLVYLGFIALIGIPIVLAEFTIGRRAQSDAVGSFEKLAPGKPWKVAGLMGVAAGFLILSFYGVIAGWILFYLFNYITGQLWSAPAEGFGGFFEGFIANPTLPLFWQALFMIATIWIVAIGVKKGIERSNKILMPLLGVLLIALAIYSLTLGGAKEGLAFLFSPDWSALKDPGVYLAAISQAFFTLSLGMGALITYGSYVSKDSRLPGAAVSVAGLDTAFAIIAGIMIFPAVFALGLSPSGGPGLVFVVLPDIFDSIRLGPIVGIAFFILLGAAALSSAVSLLEVPVAYFMRKFDWSRKQAAITLGVIITLLGIPSSLSFGVLGEVTIIPGLNIFDSVDFIASSVFLPLGGMIIALFIGWGWKTSDALAESDLTDSVWGKLWILSLRFIAPIAILIVFLSAFQ 7c3l A 1.8 BS02 TYR A 1 R68 F216 Y369 W371 F439 A475 W476 R65 F213 Y366 W368 F434 A470 W471 1.4.3.14 0016491 A0A0G4DCU0 32894626 602 ELPPRKVCIVGAGVSGLYIAMILDDLKIPNLTYDIFESSSRTGGRLYTHHFTDAKHDYYDIGAMRYPDIPSMKRTFNLFKRTGMPLIKYYLDGENTPQLYNNHFFAKGVVDPYMVSVANGGTVPDDVVDSVGEKLQQAFGYYKEKLAEDFDKGFDELMLVDDMTTREYLKRGGPKGEAPKYDFFAIQWMETQNTGTNLFDQAFSESVIASFDFDNPTKPEWYCIEGGTSLLVDAMKETLVHKVQNNKRVEAISIDLDAPDDGNMSVKIGGKDYSGYSTVFNTTALGCLDRMDLRGLNLHPTQADAIRCLHYANSTKVALKFSYPWWIKDCGITCGGAASTDLPLRTCVYPSYNLGDTGEAVLLASYTWSQDATRIGSLVKDAPPQPEDELVELILQNLARLHAEHMTYEKIKEAYTGVYHAYCWANDPNVGGAFALFGPGQFSNLYPYLMRPAAGGKFHIVGEASSVHHAWIIGSLESAYTAVYQFLYKYKMWDYLRLLLERWQY 7c3l B 1.8 BS02 TYR B 1 R68 F216 Y369 W371 F439 A475 W476 R65 F213 Y366 W368 F434 A470 W471 1.4.3.14 0016491 A0A0G4DCU0 32894626 602 ELPPRKVCIVGAGVSGLYIAMILDDLKIPNLTYDIFESSSRTGGRLYTHHFTDAKHDYYDIGAMRYPDIPSMKRTFNLFKRTGMPLIKYYLDGENTPQLYNNHFFAKGVVDPYMVSVANGGTVPDDVVDSVGEKLQQAFGYYKEKLAEDFDKGFDELMLVDDMTTREYLKRGGPKGEAPKYDFFAIQWMETQNTGTNLFDQAFSESVIASFDFDNPTKPEWYCIEGGTSLLVDAMKETLVHKVQNNKRVEAISIDLDAPDDGNMSVKIGGKDYSGYSTVFNTTALGCLDRMDLRGLNLHPTQADAIRCLHYANSTKVALKFSYPWWIKDCGITCGGAASTDLPLRTCVYPSYNLGDTGEAVLLASYTWSQDATRIGSLVKDAPPQPEDELVELILQNLARLHAEHMTYEKIKEAYTGVYHAYCWANDPNVGGAFALFGPGQFSNLYPYLMRPAAGGKFHIVGEASSVHHAWIIGSLESAYTAVYQFLYKYKMWDYLRLLLERWQY 7dkb A 2.03 BS02 TYR A 1 H84 W214 I650 T651 G652 S655 D672 G673 H62 W192 I628 T629 G630 S633 D650 G651 3.4.14.- 0008239,0070009 B4SLK2 33846449 802 AEGMWVPQQLPEIAGPLQKAGLKLSPEQLANLTGDPMGAVVALGGCTASFVSPQGLVVTNHHCAYGAIQLNSTAQKNLIKDGFNAPTLKDELSAGPNARVFVLDQITDVTAQAKAAIAGAGNDPLARSRALDAFDKAQVAACEADAGFRCRLYSFSGGNTYRLFRNMEIKDVRLVYAPPGSVGKFGGDVDNWMWPRHTGDFSFYRAYVGKDGKPAAFAADNVPYQPKHFLKFADQPLGADDFVMVAGYPGRTNRYALAGEFNETASFTYPTIAKHYNAVLKMIADAGKADADVKVKYAATAASMNNVAKNYLGQLEGFKRIDAAGQKQAEEAAVLAWLKKQGAAGKPALAAHAQLLKHLDTSKSTRERDLFVGQFNNTSAVGAAITLYRLSIERSKPDAEREAGYQERDLTTIEGGLKQMDRRYVAKMDQQLQTYWLDQYVALPAAQRDNEVLNKWLAGSDAAAVKSLVNKLGGTELGSLDTRLKWFKADRAAFEASNDPAIQYAVAVMPALLKQEEQKKIREGESLTARPLYLQAVADYKKSQGEFVYPDANLSLRITFGNVMGYGKDGVKYTPFTTLEGVAAKETGEDPFDSPKALLDAVKAKRYGGLEDKRLGSVPVNFLSNLDITGGNSGSPVLDANGKLVGLAFDGNWESVSSNWVFDPVMTRMIAVDSRYMQWIMQEVAPAPQLLKELNLA 7dkb B 2.03 BS02 TYR B 1 H84 W214 I650 T651 G652 S655 D672 G673 H62 W192 I628 T629 G630 S633 D650 G651 3.4.14.- 0008239,0070009 B4SLK2 33846449 802 AEGMWVPQQLPEIAGPLQKAGLKLSPEQLANLTGDPMGAVVALGGCTASFVSPQGLVVTNHHCAYGAIQLNSTAQKNLIKDGFNAPTLKDELSAGPNARVFVLDQITDVTAQAKAAIAGAGNDPLARSRALDAFDKAQVAACEADAGFRCRLYSFSGGNTYRLFRNMEIKDVRLVYAPPGSVGKFGGDVDNWMWPRHTGDFSFYRAYVGKDGKPAAFAADNVPYQPKHFLKFADQPLGADDFVMVAGYPGRTNRYALAGEFNETASFTYPTIAKHYNAVLKMIADAGKADADVKVKYAATAASMNNVAKNYLGQLEGFKRIDAAGQKQAEEAAVLAWLKKQGAAGKPALAAHAQLLKHLDTSKSTRERDLFVGQFNNTSAVGAAITLYRLSIERSKPDAEREAGYQERDLTTIEGGLKQMDRRYVAKMDQQLQTYWLDQYVALPAAQRDNEVLNKWLAGSDAAAVKSLVNKLGGTELGSLDTRLKWFKADRAAFEASNDPAIQYAVAVMPALLKQEEQKKIREGESLTARPLYLQAVADYKKSQGEFVYPDANLSLRITFGNVMGYGKDGVKYTPFTTLEGVAAKETGEDPFDSPKALLDAVKAKRYGGLEDKRLGSVPVNFLSNLDITGGNSGSPVLDANGKLVGLAFDGNWESVSSNWVFDPVMTRMIAVDSRYMQWIMQEVAPAPQLLKELNLA 7dkc A 1.86 BS01 TYR A 1 H84 K206 N213 W214 R218 D222 N328 D672 H62 K184 N191 W192 R196 D200 N306 D650 3.4.14.- 0008239,0070009 B4SLK2 33846449 801 AEGMWVPQQLPEIAGPLQKAGLKLSPEQLANLTGDPMGAVVALGGCTASFVSPQGLVVTNHHCAYGAIQLNSTAQKNLIKDGFNAPTLKDELSAGPNARVFVLDQITDVTAQAKAAIAGAGNDPLARSRALDAFDKAQVAACEADAGFRCRLYSFSGGNTYRLFRNMEIKDVRLVYAPPGSVGKFGGDVDNWMWPRHTGDFSFYRAYVGKDGKPAAFAADNVPYQPKHFLKFADQPLGADDFVMVAGYPGRTNRYALAGEFNETASFTYPTIAKHYNAVLKMIADAGKADADVKVKYAATAASMNNVAKNYLGQLEGFKRIDAAGQKQAEEAAVLAWLKKQGAAGKPALAAHAQLLKHLDTSKSTRERDLFVGQFNNTSAVGAAITLYRLSIERSKPDAEREAGYQERDLTTIEGGLKQMDRRYVAKMDQQLQTYWLDQYVALPAAQRDNEVLNKWLAGSDAAAVKSLVNKLGGTELGSLDTRLKWFKADRAAFEASNDPAIQYAVAVMPALLKQEEQKKIREGESLTARPLYLQAVADYKKSQGEFVYPDANLSLRITFGNVMGYGKDGVKYTPFTTLEGVAAKETGEDPFDSPKALLDAVKAKRYGGLEDKRLGSVPVNFLSNLDITGGNSGSPVLDANGKLVGLAFDGNWESVSSNWVFDPVMTRMIAVDSRYMQWIMQEVAPAPQLLKELNLA 7dkc A 1.86 BS02 TYR A 2 H84 W214 I650 T651 G652 S655 D672 G673 H62 W192 I628 T629 G630 S633 D650 G651 3.4.14.- 0008239,0070009 B4SLK2 33846449 802 AEGMWVPQQLPEIAGPLQKAGLKLSPEQLANLTGDPMGAVVALGGCTASFVSPQGLVVTNHHCAYGAIQLNSTAQKNLIKDGFNAPTLKDELSAGPNARVFVLDQITDVTAQAKAAIAGAGNDPLARSRALDAFDKAQVAACEADAGFRCRLYSFSGGNTYRLFRNMEIKDVRLVYAPPGSVGKFGGDVDNWMWPRHTGDFSFYRAYVGKDGKPAAFAADNVPYQPKHFLKFADQPLGADDFVMVAGYPGRTNRYALAGEFNETASFTYPTIAKHYNAVLKMIADAGKADADVKVKYAATAASMNNVAKNYLGQLEGFKRIDAAGQKQAEEAAVLAWLKKQGAAGKPALAAHAQLLKHLDTSKSTRERDLFVGQFNNTSAVGAAITLYRLSIERSKPDAEREAGYQERDLTTIEGGLKQMDRRYVAKMDQQLQTYWLDQYVALPAAQRDNEVLNKWLAGSDAAAVKSLVNKLGGTELGSLDTRLKWFKADRAAFEASNDPAIQYAVAVMPALLKQEEQKKIREGESLTARPLYLQAVADYKKSQGEFVYPDANLSLRITFGNVMGYGKDGVKYTPFTTLEGVAAKETGEDPFDSPKALLDAVKAKRYGGLEDKRLGSVPVNFLSNLDITGGNSGSPVLDANGKLVGLAFDGNWESVSSNWVFDPVMTRMIAVDSRYMQWIMQEVAPAPQLLKELNLA 7dkc B 1.86 BS01 TYR B 1 H84 N213 W214 R218 D222 N328 D672 H62 N191 W192 R196 D200 N306 D650 3.4.14.- 0008239,0070009 B4SLK2 33846449 801 AEGMWVPQQLPEIAGPLQKAGLKLSPEQLANLTGDPMGAVVALGGCTASFVSPQGLVVTNHHCAYGAIQLNSTAQKNLIKDGFNAPTLKDELSAGPNARVFVLDQITDVTAQAKAAIAGAGNDPLARSRALDAFDKAQVAACEADAGFRCRLYSFSGGNTYRLFRNMEIKDVRLVYAPPGSVGKFGGDVDNWMWPRHTGDFSFYRAYVGKDGKPAAFAADNVPYQPKHFLKFADQPLGADDFVMVAGYPGRTNRYALAGEFNETASFTYPTIAKHYNAVLKMIADAGKADADVKVKYAATAASMNNVAKNYLGQLEGFKRIDAAGQKQAEEAAVLAWLKKQGAAGKPALAAHAQLLKHLDTSKSTRERDLFVGQFNNTSAVGAAITLYRLSIERSKPDAEREAGYQERDLTTIEGGLKQMDRRYVAKMDQQLQTYWLDQYVALPAAQRDNEVLNKWLAGSDAAAVKSLVNKLGGTELGSLDTRLKWFKADRAAFEASNDPAIQYAVAVMPALLKQEEQKKIREGESLTARPLYLQAVADYKKSQGEFVYPDANLSLRITFGNVMGYGKDGVKYTPFTTLEGVAAKETGEDPFDSPKALLDAVKAKRYGGLEDKRLGSVPVNFLSNLDITGGNSGSPVLDANGKLVGLAFDGNWESVSSNWVFDPVMTRMIAVDSRYMQWIMQEVAPAPQLLKELNLA 7dkc B 1.86 BS02 TYR B 2 H84 W214 I650 T651 G652 S655 D672 G673 H62 W192 I628 T629 G630 S633 D650 G651 3.4.14.- 0008239,0070009 B4SLK2 33846449 802 AEGMWVPQQLPEIAGPLQKAGLKLSPEQLANLTGDPMGAVVALGGCTASFVSPQGLVVTNHHCAYGAIQLNSTAQKNLIKDGFNAPTLKDELSAGPNARVFVLDQITDVTAQAKAAIAGAGNDPLARSRALDAFDKAQVAACEADAGFRCRLYSFSGGNTYRLFRNMEIKDVRLVYAPPGSVGKFGGDVDNWMWPRHTGDFSFYRAYVGKDGKPAAFAADNVPYQPKHFLKFADQPLGADDFVMVAGYPGRTNRYALAGEFNETASFTYPTIAKHYNAVLKMIADAGKADADVKVKYAATAASMNNVAKNYLGQLEGFKRIDAAGQKQAEEAAVLAWLKKQGAAGKPALAAHAQLLKHLDTSKSTRERDLFVGQFNNTSAVGAAITLYRLSIERSKPDAEREAGYQERDLTTIEGGLKQMDRRYVAKMDQQLQTYWLDQYVALPAAQRDNEVLNKWLAGSDAAAVKSLVNKLGGTELGSLDTRLKWFKADRAAFEASNDPAIQYAVAVMPALLKQEEQKKIREGESLTARPLYLQAVADYKKSQGEFVYPDANLSLRITFGNVMGYGKDGVKYTPFTTLEGVAAKETGEDPFDSPKALLDAVKAKRYGGLEDKRLGSVPVNFLSNLDITGGNSGSPVLDANGKLVGLAFDGNWESVSSNWVFDPVMTRMIAVDSRYMQWIMQEVAPAPQLLKELNLA 7dkd A 1.92 BS02 TYR A 1 H84 W214 I650 T651 G652 S655 D672 G673 H62 W192 I628 T629 G630 S633 D650 G651 3.4.14.- 0008239,0070009 B4SLK2 33846449 802 AEGMWVPQQLPEIAGPLQKAGLKLSPEQLANLTGDPMGAVVALGGCTASFVSPQGLVVTNHHCAYGAIQLNSTAQKNLIKDGFNAPTLKDELSAGPNARVFVLDQITDVTAQAKAAIAGAGNDPLARSRALDAFDKAQVAACEADAGFRCRLYSFSGGNTYRLFRNMEIKDVRLVYAPPGSVGKFGGDVDNWMWPRHTGDFSFYRAYVGKDGKPAAFAADNVPYQPKHFLKFADQPLGADDFVMVAGYPGRTNRYALAGEFNETASFTYPTIAKHYNAVLKMIADAGKADADVKVKYAATAASMNNVAKNYLGQLEGFKRIDAAGQKQAEEAAVLAWLKKQGAAGKPALAAHAQLLKHLDTSKSTRERDLFVGQFNNTSAVGAAITLYRLSIERSKPDAEREAGYQERDLTTIEGGLKQMDRRYVAKMDQQLQTYWLDQYVALPAAQRDNEVLNKWLAGSDAAAVKSLVNKLGGTELGSLDTRLKWFKADRAAFEASNDPAIQYAVAVMPALLKQEEQKKIREGESLTARPLYLQAVADYKKSQGEFVYPDANLSLRITFGNVMGYGKDGVKYTPFTTLEGVAAKETGEDPFDSPKALLDAVKAKRYGGLEDKRLGSVPVNFLSNLDITGGNSGSPVLDANGKLVGLAFDGNWESVSSNWVFDPVMTRMIAVDSRYMQWIMQEVAPAPQLLKELNLA 7dkd B 1.92 BS02 TYR B 1 W214 I650 T651 G652 S655 D672 G673 W192 I628 T629 G630 S633 D650 G651 3.4.14.- 0008239,0070009 B4SLK2 33846449 802 AEGMWVPQQLPEIAGPLQKAGLKLSPEQLANLTGDPMGAVVALGGCTASFVSPQGLVVTNHHCAYGAIQLNSTAQKNLIKDGFNAPTLKDELSAGPNARVFVLDQITDVTAQAKAAIAGAGNDPLARSRALDAFDKAQVAACEADAGFRCRLYSFSGGNTYRLFRNMEIKDVRLVYAPPGSVGKFGGDVDNWMWPRHTGDFSFYRAYVGKDGKPAAFAADNVPYQPKHFLKFADQPLGADDFVMVAGYPGRTNRYALAGEFNETASFTYPTIAKHYNAVLKMIADAGKADADVKVKYAATAASMNNVAKNYLGQLEGFKRIDAAGQKQAEEAAVLAWLKKQGAAGKPALAAHAQLLKHLDTSKSTRERDLFVGQFNNTSAVGAAITLYRLSIERSKPDAEREAGYQERDLTTIEGGLKQMDRRYVAKMDQQLQTYWLDQYVALPAAQRDNEVLNKWLAGSDAAAVKSLVNKLGGTELGSLDTRLKWFKADRAAFEASNDPAIQYAVAVMPALLKQEEQKKIREGESLTARPLYLQAVADYKKSQGEFVYPDANLSLRITFGNVMGYGKDGVKYTPFTTLEGVAAKETGEDPFDSPKALLDAVKAKRYGGLEDKRLGSVPVNFLSNLDITGGNSGSPVLDANGKLVGLAFDGNWESVSSNWVFDPVMTRMIAVDSRYMQWIMQEVAPAPQLLKELNLA 7dke A 1.91 BS02 TYR A 1 H84 W214 I650 T651 G652 S655 D672 G673 H62 W192 I628 T629 G630 S633 D650 G651 3.4.14.- 0008239,0070009 B4SLK2 33846449 802 AEGMWVPQQLPEIAGPLQKAGLKLSPEQLANLTGDPMGAVVALGGCTASFVSPQGLVVTNHHCAYGAIQLNSTAQKNLIKDGFNAPTLKDELSAGPNARVFVLDQITDVTAQAKAAIAGAGNDPLARSRALDAFDKAQVAACEADAGFRCRLYSFSGGNTYRLFRNMEIKDVRLVYAPPGSVGKFGGDVDNWMWPRHTGDFSFYRAYVGKDGKPAAFAADNVPYQPKHFLKFADQPLGADDFVMVAGYPGRTNRYALAGEFNETASFTYPTIAKHYNAVLKMIADAGKADADVKVKYAATAASMNNVAKNYLGQLEGFKRIDAAGQKQAEEAAVLAWLKKQGAAGKPALAAHAQLLKHLDTSKSTRERDLFVGQFNNTSAVGAAITLYRLSIERSKPDAEREAGYQERDLTTIEGGLKQMDRRYVAKMDQQLQTYWLDQYVALPAAQRDNEVLNKWLAGSDAAAVKSLVNKLGGTELGSLDTRLKWFKADRAAFEASNDPAIQYAVAVMPALLKQEEQKKIREGESLTARPLYLQAVADYKKSQGEFVYPDANLSLRITFGNVMGYGKDGVKYTPFTTLEGVAAKETGEDPFDSPKALLDAVKAKRYGGLEDKRLGSVPVNFLSNLDITGGNSGSPVLDANGKLVGLAFDGNWESVSSNWVFDPVMTRMIAVDSRYMQWIMQEVAPAPQLLKELNLA 7dke B 1.91 BS02 TYR B 1 H84 W214 I650 T651 G652 S655 D672 G673 H62 W192 I628 T629 G630 S633 D650 G651 3.4.14.- 0008239,0070009 B4SLK2 33846449 802 AEGMWVPQQLPEIAGPLQKAGLKLSPEQLANLTGDPMGAVVALGGCTASFVSPQGLVVTNHHCAYGAIQLNSTAQKNLIKDGFNAPTLKDELSAGPNARVFVLDQITDVTAQAKAAIAGAGNDPLARSRALDAFDKAQVAACEADAGFRCRLYSFSGGNTYRLFRNMEIKDVRLVYAPPGSVGKFGGDVDNWMWPRHTGDFSFYRAYVGKDGKPAAFAADNVPYQPKHFLKFADQPLGADDFVMVAGYPGRTNRYALAGEFNETASFTYPTIAKHYNAVLKMIADAGKADADVKVKYAATAASMNNVAKNYLGQLEGFKRIDAAGQKQAEEAAVLAWLKKQGAAGKPALAAHAQLLKHLDTSKSTRERDLFVGQFNNTSAVGAAITLYRLSIERSKPDAEREAGYQERDLTTIEGGLKQMDRRYVAKMDQQLQTYWLDQYVALPAAQRDNEVLNKWLAGSDAAAVKSLVNKLGGTELGSLDTRLKWFKADRAAFEASNDPAIQYAVAVMPALLKQEEQKKIREGESLTARPLYLQAVADYKKSQGEFVYPDANLSLRITFGNVMGYGKDGVKYTPFTTLEGVAAKETGEDPFDSPKALLDAVKAKRYGGLEDKRLGSVPVNFLSNLDITGGNSGSPVLDANGKLVGLAFDGNWESVSSNWVFDPVMTRMIAVDSRYMQWIMQEVAPAPQLLKELNLA 7kqr A 1.89 BS02 TYR A 1 W84 H88 Y141 R146 M149 F156 G158 S209 W79 H83 Y136 R141 M144 F151 G153 S204 33734681 402 GTVLTELPDHGRWDFGDFPYGLEPLTLPEPGSLEAADSGSVPAEFTLTCRHIAAIAAGGGPAERVQPADSSDRLYWFRWITGHQVTFILWQLLSRELARLPEEGPERDAALKAMTRYVRGYCAMLLYTGSMPRTVYGDVIRPSMFLQHPGFSGTWAPDHKPVQALFRGKKLPCVRDSADLAQAVHVYQVIHAGIAARMVPSGRSLLQEASVPSGVQHPDVLGVVYDNYFLTLRSRPSSRDVVAQLLRRLTAIALDVKDNALYPDGREAGSELPEELTRPEVTGHERDFLAILSEVAEEATGSP 7kqr B 1.89 BS02 TYR B 1 W84 H88 Y141 R146 M149 F156 S157 G158 S209 Y230 W79 H83 Y136 R141 M144 F151 S152 G153 S204 Y225 33734681 402 GTVLTELPDHGRWDFGDFPYGLEPLTLPEPGSLEAADSGSVPAEFTLTCRHIAAIAAGGGPAERVQPADSSDRLYWFRWITGHQVTFILWQLLSRELARLPEEGPERDAALKAMTRYVRGYCAMLLYTGSMPRTVYGDVIRPSMFLQHPGFSGTWAPDHKPVQALFRGKKLPCVRDSADLAQAVHVYQVIHAGIAARMVPSGRSLLQEASVPSGVQHPDVLGVVYDNYFLTLRSRPSSRDVVAQLLRRLTAIALDVKDNALYPDGREAGSELPEELTRPEVTGHERDFLAILSEVAEEATG 7pd1 A 1.27 BS03 TYR A 1 Y76 P78 E158 Y181 S298 T299 R300 S318 S321 F337 Y75 P77 E157 Y180 S297 T298 R299 S317 S320 F336 ? 0003824,0005506,0009228,0042364,0044272,0046872,0051536,0051539 A1HPQ5 35477710 404 GTFYDVIEDYRHFDFAAYFAKVTDSDVRRILRQDRLSALDFLTLLSPQAEAYLEEMAQKAHRLTVQHFGRTMLLYTPLYLANYCVNQCVYCGFQLKNKLERKKLTLAEVEQEAQLIAATGLKHILILTGESRQHSPVSYIKDCVNILKKYFSSISIEIYPLTQEEYAELIGAGVDGLTIYQEVYNEEVYAEMHPAGPKRNYRFRLEAPERACQAGMRTVNIGALLGLNDWRQEAFFTGLHADYLQRRFPDVEVSISPPRMRPHLGGFPPRVVVSDQNLVQYVLAFRLFMPRSGITLSTRENGRLRDAMVRLGVTKMSAGSCTAVGGRSDQEAVGQFQISDERTVAEVAAMLYAQGYQPVYKDWQAL 7pd1 B 1.27 BS03 TYR B 1 Y76 P78 E158 Y181 S298 T299 R300 S318 S321 F337 Y76 P78 E158 Y181 S298 T299 R300 S318 S321 F337 ? 0003824,0005506,0009228,0042364,0044272,0046872,0051536,0051539 A1HPQ5 35477710 404 SGTFYDVIEDYRHFDFAAYFAKVTDSDVRRILRQDRLSALDFLTLLSPQAEAYLEEMAQKAHRLTVQHFGRTMLLYTPLYLANYCVNQCVYCGFQLKNKLERKKLTLAEVEQEAQLIAATGLKHILILTGESRQHSPVSYIKDCVNILKKYFSSISIEIYPLTQEEYAELIGAGVDGLTIYQEVYNEEVYAEMHPAGPKRNYRFRLEAPERACQAGMRTVNIGALLGLNDWRQEAFFTGLHADYLQRRFPDVEVSISPPRMRPHLGGFPPRVVVSDQNLVQYVLAFRLFMPRSGITLSTRENGRLRDAMVRLGVTKMSAGSCTAVGGRSDQEAVGQFQISDERTVAEVAAMLYAQGYQPVYKDWQAL 7qi1 C 1.76 BS02 TYR C 1 T217 M220 R224 T220 M223 R227 ? S7N159 35739107 303 MGSMTMDKSELVQKAKLAEQAERYDDMAAAMKAVTEQGHELSNEERNLLSVAYKNVVGARRSSWRVISSIEQKTERNEKKQQMGKEYREKIEAELQDICNDVLELLDKYLIPNATQPESKVFYLKMKGDYFRYLSEVASGDNKQTTVSNSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLNEESYKDSTLIMQLLRDNLTLWT 7reu A 2.79 BS01 TYR A 1 T153 Q157 S160 L185 S186 F215 T144 Q148 S151 L176 S177 F206 2.5.1.54 0003849,0005737,0008652,0009058,0009073,0016740 A0A2H0ZNV2 401 PIPEEYDDTRIMGYDPLIPPALLQNEIKASKKSLETVIKGRVDASRIIGGKDDRCLVIVGPCSIHDPEAALEYANRLKKISEELENDLVIIMRAYLEKGWKGLINDPNVDNSFDINKGLRVSRKLYADLTGAVGIPIGSEMLDTISPQYFSDLLSFGAVGARTTESQLHRELASGLSFPIGFKNGTDGNVGVALDAVQASSKGHHFMGVTKNGLAAITTTKGNDHCFIILRGGKNLTNYDLQSVQSAKSAIAKSSNPNIKIMIDCSHDNSKKDYRNQPAVLEDVSRQIEAGENALMGVMIESNINEGKQSMALKYGVSITDSCVSWDTTVKMLNNLARAVQKRRQKNG 7reu A 2.79 BS02 TYR B 1 D12 Y18 D8 Y14 2.5.1.54 0003849,0005737,0008652,0009058,0009073,0016740 A0A2H0ZNV2 401 PIPEEYDDTRIMGYDPLIPPALLQNEIKASKKSLETVIKGRVDASRIIGGKDDRCLVIVGPCSIHDPEAALEYANRLKKISEELENDLVIIMRAYLEKGWKGLINDPNVDNSFDINKGLRVSRKLYADLTGAVGIPIGSEMLDTISPQYFSDLLSFGAVGARTTESQLHRELASGLSFPIGFKNGTDGNVGVALDAVQASSKGHHFMGVTKNGLAAITTTKGNDHCFIILRGGKNLTNYDLQSVQSAKSAIAKSSNPNIKIMIDCSHDNSKKDYRNQPAVLEDVSRQIEAGENALMGVMIESNINEGKQSMALKYGVSITDSCVSWDTTVKMLNNLARAVQKRRQKNG 7reu B 2.79 BS01 TYR A 1 D11 D12 D4 D5 2.5.1.54 0003849,0005737,0008652,0009058,0009073,0016740 A0A2H0ZNV2 401 EEYDDTRIMGYDPLIPPALLQNEIKASKKSLETVIKGRVDASRIIGGKDDRCLVIVGPCSIHDPEAALEYANRLKKISEELENDLVIIMRAYLEKPRTTVGWKGLINDPNVDNSFDINKGLRVSRKLYADLTGAVGIPIGSEMLDTISPQYFSDLLSFGAVGARTTESQLHRELASGLSFPIGFKNGTDGNVGVALDAVQASSKGHHFMGVTKNGLAAITTTKGNDHCFIILRGGKNLTNYDLQSVQSAKSAIAKSSNPNIKIMIDCSHDNSKKDYRNQPAVLEDVSRQIEAGENALMGVMIESNINEGKQSMPSGNEGKSALKYGVSITDSCVSWDTTVKMLNNLARAVQKRRQKNG 7reu B 2.79 BS02 TYR B 1 T153 Q157 S160 L185 S186 T146 Q150 S153 L178 S179 2.5.1.54 0003849,0005737,0008652,0009058,0009073,0016740 A0A2H0ZNV2 401 EEYDDTRIMGYDPLIPPALLQNEIKASKKSLETVIKGRVDASRIIGGKDDRCLVIVGPCSIHDPEAALEYANRLKKISEELENDLVIIMRAYLEKPRTTVGWKGLINDPNVDNSFDINKGLRVSRKLYADLTGAVGIPIGSEMLDTISPQYFSDLLSFGAVGARTTESQLHRELASGLSFPIGFKNGTDGNVGVALDAVQASSKGHHFMGVTKNGLAAITTTKGNDHCFIILRGGKNLTNYDLQSVQSAKSAIAKSSNPNIKIMIDCSHDNSKKDYRNQPAVLEDVSRQIEAGENALMGVMIESNINEGKQSMPSGNEGKSALKYGVSITDSCVSWDTTVKMLNNLARAVQKRRQKNG 7rs3 B 1.84 BS01 TYR B 1 H524 L525 H211 L212 ? P03372 34452998 601 KNSLALSLTADQMVSALLDAEPPILYSSMMGLLTNLADRELVHMINWAKRVPGFVDLTSHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHL 7rs3 C 1.84 BS01 TYR C 1 M522 L525 M195 L198 ? P03372 34452998 601 SLALSLTADQMVSALLDAEPPIYSSMMGLLTNLADRELVHMINWAKRVPGFVDLTSHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHL 7ux8 A 1.4 BS02 TYR A 1 K122 L165 W172 N268 H271 F319 K117 L160 W167 N263 H266 F314 ? 0008168,0008171 A0A0D4WTP2 36173166 402 NVSLVDESLLVGVTDEDRAVRSAHQFYERLIGLWAPAVMEAAHELGVFAALAEAPADSGELARRLDCDARAMRVLLDALYAYDVIDRIHDTNGFRYLLSAEARECLLPGTLFSLVGKFMHDINVAWPAWRNLAEVVRHGARDTSGAESPNGIAQEDYESLVGGINFWAPPIVTTLSRKLRASGRSGDATASVLDVGCGTGLYSQLLLREFPRWTATGLDVERIATLANAQALRLGVEERFATRAGDFWRGGWGTGYDLVLFANIFHLQTPASAVRLMRHAAACLAPDGLVAVVDQIVDADREPKTPQDRFALLFAASMTNTGGGDAYTFQEYEEWFTAAGLQRIETLDTPMHRILLARRATEPSAVPEGQASENLYFQ 7ux8 A 1.4 BS03 TYR B 1 Y32 W39 Y27 W34 ? 0008168,0008171 A0A0D4WTP2 36173166 402 NVSLVDESLLVGVTDEDRAVRSAHQFYERLIGLWAPAVMEAAHELGVFAALAEAPADSGELARRLDCDARAMRVLLDALYAYDVIDRIHDTNGFRYLLSAEARECLLPGTLFSLVGKFMHDINVAWPAWRNLAEVVRHGARDTSGAESPNGIAQEDYESLVGGINFWAPPIVTTLSRKLRASGRSGDATASVLDVGCGTGLYSQLLLREFPRWTATGLDVERIATLANAQALRLGVEERFATRAGDFWRGGWGTGYDLVLFANIFHLQTPASAVRLMRHAAACLAPDGLVAVVDQIVDADREPKTPQDRFALLFAASMTNTGGGDAYTFQEYEEWFTAAGLQRIETLDTPMHRILLARRATEPSAVPEGQASENLYFQ 7ux8 B 1.4 BS01 TYR A 1 Y32 W39 Y27 W34 ? 0008168,0008171 A0A0D4WTP2 36173166 402 NVSLVDESLLVGVTDEDRAVRSAHQFYERLIGLWAPAVMEAAHELGVFAALAEAPADSGELARRLDCDARAMRVLLDALYAYDVIDRIHDTNGFRYLLSAEARECLLPGTLFSLVGKFMHDINVAWPAWRNLAEVVRHGARDTSGAESPNGIAQEDYESLVGGINFWAPPIVTTLSRKLRASGRSGDATASVLDVGCGTGLYSQLLLREFPRWTATGLDVERIATLANAQALRLGVEERFATRAGDFWRGGWGTGYDLVLFANIFHLQTPASAVRLMRHAAACLAPDGLVAVVDQIVDADREPKTPQDRFALLFAASMTNTGGGDAYTFQEYEEWFTAAGLQRIETLDTPMHRILLARRAT 7ux8 B 1.4 BS03 TYR B 1 K122 L165 N268 H271 F319 S322 K117 L160 N263 H266 F314 S317 ? 0008168,0008171 A0A0D4WTP2 36173166 402 NVSLVDESLLVGVTDEDRAVRSAHQFYERLIGLWAPAVMEAAHELGVFAALAEAPADSGELARRLDCDARAMRVLLDALYAYDVIDRIHDTNGFRYLLSAEARECLLPGTLFSLVGKFMHDINVAWPAWRNLAEVVRHGARDTSGAESPNGIAQEDYESLVGGINFWAPPIVTTLSRKLRASGRSGDATASVLDVGCGTGLYSQLLLREFPRWTATGLDVERIATLANAQALRLGVEERFATRAGDFWRGGWGTGYDLVLFANIFHLQTPASAVRLMRHAAACLAPDGLVAVVDQIVDADREPKTPQDRFALLFAASMTNTGGGDAYTFQEYEEWFTAAGLQRIETLDTPMHRILLARRAT 7vys r 2.5 BS03 TYR r 1 K452 L455 G456 P457 L458 K452 L455 G456 P457 L458 7.1.1.2 0003954,0005739,0005743,0006120,0008137,0009060,0015990,0032981,0042773,0045271,0048039 O79881 35145322 503 MLKIIIPTTMLLPMTWMSKHNMIWINATVHSLLISLISLSLLNQLGENSLNFSLTFFSDSLSAPLLVLTTWLLPLMLMASQSHLSKETTTRKKLYITMLILLQLFLIMTFTATELILFYILFEATLVPTLIIITRWGNQTERLNAGLYFLFYTLAGSLPLLVALVYIQNTTGSLNFLIIHYWSHPLSNSWSNIFMWLACIMAFMVKMPLYGLHLWLPKAHVEAPIAGSMVLAAVLLKLGGYGMMRITTILNPLTNYMAYPFLMLSMWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIVAIMIQTPWSFMGATALMIAHGLTSSMLFCLANTNYERVHSRTMILARGLQTLLPLMATWWLVASLTNLALPPSINLIGELFIITASFSWSNITIILMGMNMMITALYSLYMLITTQRGKYTHHINNIKPSFTRENALMALHILPLLLLTLNPKMILGPL 8day A 2.55 BS01 TYR A 1 F81 M82 R257 T313 Y389 F72 M73 R241 T297 Y373 2.5.1.- 0009820,0016740,0016765 S0EH60 36084241 501 QSVWKTLNKWLPPLSRDKDWWWKTLGPQINTLLTEADYDLNERYEALLLLYRWVVPEMGPRPRSSVAPSKSFMTDDHSPIEYSWKWISGNKKPEIRYAVELVSPLAGSKQDPFNQIPTRNLVYNLAKIIPELDLTWFEHFWHELLGPGSPLTKGSTVFAALEMLHGHLSVKVYFIPVETPDFSAWHQIKHAIEASGCPNLEALNHVDAYLSSHDDGRQLRPFMLAIDLVEPAASRLKIYARSNQTSFRFVRDVMTIGGLRTDLDRSIEKFSDLWKRALGLDPDTPPEDELPKVDHLTSGAVFNFDVAPKSQIPEVKAYIPVRHYANNDLQAALGLIGYLEDHGHGGYSQSYLRGLDMLAPSGQLDQATGVQTYFAVACQGEDLSLTSYLNPQFYAAFQ 8grt A 2.59 BS02 TYR A 1 W214 I650 T651 G652 S655 F671 D672 G673 W192 I628 T629 G630 S633 F649 D650 G651 3.4.14.- 0008239,0070009 B4SLK2 802 AEGMWVPQQLPEIAGPLQKAGLKLSPEQLANLTGDPMGAVVALGGCTASFVSPQGLVVTNHHCAYGAIQLNSTAQKNLIKDGFNAPTLKDELSAGPNARVFVLDQITDVTAQAKAAIAGAGNDPLARSRALDAFDKAQVAACEADAGFRCRLYSFSGGNTYRLFRNMEIKDVRLVYAPPGSVGKFGGDVDNWMWPRHTGDFSFYRAYVGKDGKPAAFAADNVPYQPKHFLKFADQPLGADDFVMVAGYPGRTNRYALAGEFNETASFTYPTIAKHYNAVLKMIADAGKADADVKVKYAATAASMNNVAKNYLGQLEGFKRIDAAGQKQAEEAAVLAWLKKQGAAGKPALAAHAQLLKHLDTSKSTRERDLFVGQFNNTSAVGAAITLYRLSIERSKPDAEREAGYQERDLTTIEGGLKQMDRRYVAKMDQQLQTYWLDQYVALPAAQRDNEVLNKWLAGSDAAAVKSLVNKLGGTELGSLDTRLKWFKADRAAFEASNDPAIQYAVAVMPALLKQEEQKKIREGESLTARPLYLQAVADYKKSQGEFVYPDANLSLRITFGNVMGYGKDGVKYTPFTTLEGVAAKETGEDPFDSPKALLDAVKAKRYGGLEDKRLGSVPVNFLSNLDITGGNSGSPVLDANGKLVGLAFDGNWESVSSNWVFDPVMTRMIAVDSRYMQWIMQEVAPAPQLLKELNLA 8grt B 2.59 BS02 TYR B 1 H84 W214 I650 T651 G652 S655 D672 G673 H61 W191 I627 T628 G629 S632 D649 G650 3.4.14.- 0008239,0070009 B4SLK2 802 EGMWVPQQLPEIAGPLQKAGLKLSPEQLANLTGDPMGAVVALGGCTASFVSPQGLVVTNHHCAYGAIQLNSTAQKNLIKDGFNAPTLKDELSAGPNARVFVLDQITDVTAQAKAAIAGAGNDPLARSRALDAFDKAQVAACEADAGFRCRLYSFSGGNTYRLFRNMEIKDVRLVYAPPGSVGKFGGDVDNWMWPRHTGDFSFYRAYVGKDGKPAAFAADNVPYQPKHFLKFADQPLGADDFVMVAGYPGRTNRYALAGEFNETASFTYPTIAKHYNAVLKMIADAGKADADVKVKYAATAASMNNVAKNYLGQLEGFKRIDAAGQKQAEEAAVLAWLKKQGAAGKPALAAHAQLLKHLDTSKSTRERDLFVGQFNNTSAVGAAITLYRLSIERSKPDAEREAGYQERDLTTIEGGLKQMDRRYVAKMDQQLQTYWLDQYVALPAAQRDNEVLNKWLAGSDAAAVKSLVNKLGGTELGSLDTRLKWFKADRAAFEASNDPAIQYAVAVMPALLKQEEQKKIREGESLTARPLYLQAVADYKKSQGEFVYPDANLSLRITFGNVMGYGKDGVKYTPFTTLEGVAAKETGEDPFDSPKALLDAVKAKRYGGLEDKRLGSVPVNFLSNLDITGGNSGSPVLDANGKLVGLAFDGNWESVSSNWVFDPVMTRMIAVDSRYMQWIMQEVAPAPQLLKELNLA 8ida B 3.2 BS01 TYR B 1 I63 G65 G67 G255 Y259 I20 G22 G24 G212 Y216 0002720,0003333,0005515,0005764,0005765,0005829,0005886,0006865,0009925,0010507,0010629,0014850,0015171,0015173,0015175,0015179,0015190,0015196,0015297,0015349,0015804,0015807,0015818,0015820,0015821,0015823,0015824,0015827,0015828,0015829,0016020,0016323,0016324,0031528,0032328,0032729,0032740,0032753,0042149,0042605,0042908,0043231,0055093,0060252,0070062,0070327,0071222,0071230,0089718,0097421,0098591,0150104,1902024,1902475,1903577,1903801,1904556,1905460,1905534,1990184 Q01650 601 VTLQRNITLLNGVAIIVGTIIGSGIFVTPTGVLKEAGSPGLALVVWAACGVFSIVGALCYAELGTTISKSGGDYAYMLEVYGSLPAFLKLWIELLIIRPSSQYIVALVFATYLLKPLFPTCPVPEEAAKLVACLCVLLLTAVNCYSVKAATRVQDAFAAAKLLALALIILLGFVQIGKGDVSNLDPNFSFEGTKLDVGNIVLALYSGLFAYGGWNYLNFVTEEMINPYRNLPLAIIISLPIVTLVYVLTNLAYFTTLSTEQMLSSEAVAVDFGNYHLGVMSWIIPVFVGLSCFGSVNGSLFTSSRLFFVGSREGHLPSILSMIHPQLLTPVPSLVFTCVMTLLYAFSKDIFSVINFFSFFNWLCVALAIIGMIWLRHRKPELERPIKVNLALPVFFILACLFLIAVSFWKTPVECGIGFTIILSGLPVYFFGVWWKNKPKWLLQGIFSTTVLCQKLMQVVPQET