1c3r A 2.0 BS02 TSN A 1 P22 H131 H132 F141 D168 H170 Y297 P21 H130 H131 F140 D167 H169 Y296 ? 0004407,0040029,0045149,0045150,0046872 -logKd/Ki=6.40, IC50=0.4uM O67135 10490031 502 KKVKLIGTLDYGKYRYPKNHPLKIPRVSLLLRFKDAMNLIDEKELIKSRPATKEELLLFHTEDYINTLMEAERSQSVPKGAREKYNIGGYENPVSYAMFTGSSLATGSTVQAIEEFLKGNVAFNPAGGMHHAFKSRANGFCYINNPAVGIEYLRKKGFKRILYIDLDAHHCDGVQEAFYDTDQVFVLSLHQSPEYAFPFEKGFLEEIGEGKGKGYNLNIPLPKGLNDNEFLFALEKSLEIVKEVFEPEVYLLQLGTDPLLEDYLSKFNLSNVAFLKAFNIVREVFGEGVYLGGGGYHPYALARAWTLIWCELSGREVPEKLNNKAKELLKSIDFEEFDDEVDRSYMLETLKDPWRGGEVRKEVKDTLEKAKA 1c3r B 2.0 BS02 TSN B 1 P22 H131 H132 F141 D168 H170 Y297 P21 H130 H131 F140 D167 H169 Y296 ? 0004407,0040029,0045149,0045150,0046872 -logKd/Ki=6.40, IC50=0.4uM O67135 10490031 504 KKVKLIGTLDYGKYRYPKNHPLKIPRVSLLLRFKDAMNLIDEKELIKSRPATKEELLLFHTEDYINTLMEAERSQSVPKGAREKYNIGGYENPVSYAMFTGSSLATGSTVQAIEEFLKGNVAFNPAGGMHHAFKSRANGFCYINNPAVGIEYLRKKGFKRILYIDLDAHHCDGVQEAFYDTDQVFVLSLHQSPEYAFPFEKGFLEEIGEGKGKGYNLNIPLPKGLNDNEFLFALEKSLEIVKEVFEPEVYLLQLGTDPLLEDYLSKFNLSNVAFLKAFNIVREVFGEGVYLGGGGYHPYALARAWTLIWCELSGREVPEKLNNKAKELLKSIDFEEFDDEVDRSYMLETLKDPWRGGEVRKEVKDTLEKAKA 1t64 A 1.9 BS02 TSN A 1 Y100 H142 H143 F152 D178 H180 Y306 Y87 H129 H130 F139 D165 H167 Y293 3.5.1.-,3.5.1.98 0000118,0000122,0000228,0004407,0005515,0005634,0005654,0005694,0005737,0006325,0007064,0016787,0030544,0031397,0031647,0032204,0033558,0040029,0046872,0051879,0140297,0160008,0160009 IC50=90nM, Ki=45nM, Kd=3.9e+2nM Q9BY41 15242608 386 LVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV 1t64 A 1.9 BS03 TSN A 2 I34 P35 W141 F152 P273 Y306 I21 P22 W128 F139 P260 Y293 3.5.1.-,3.5.1.98 0000118,0000122,0000228,0004407,0005515,0005634,0005654,0005694,0005737,0006325,0007064,0016787,0030544,0031397,0031647,0032204,0033558,0040029,0046872,0051879,0140297,0160008,0160009 IC50=90nM, Ki=45nM, Kd=3.9e+2nM Q9BY41 15242608 387 LVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV 1t64 B 1.9 BS02 TSN B 1 Y100 H142 H143 F152 D178 H180 Y306 Y87 H129 H130 F139 D165 H167 Y293 3.5.1.-,3.5.1.98 0000118,0000122,0000228,0004407,0005515,0005634,0005654,0005694,0005737,0006325,0007064,0016787,0030544,0031397,0031647,0032204,0033558,0040029,0046872,0051879,0140297,0160008,0160009 IC50=90nM, Ki=45nM, Kd=3.9e+2nM Q9BY41 15242608 1386 LVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV 1t64 B 1.9 BS03 TSN B 2 I34 P35 W141 F152 P273 Y306 I21 P22 W128 F139 P260 Y293 3.5.1.-,3.5.1.98 0000118,0000122,0000228,0004407,0005515,0005634,0005654,0005694,0005737,0006325,0007064,0016787,0030544,0031397,0031647,0032204,0033558,0040029,0046872,0051879,0140297,0160008,0160009 IC50=90nM, Ki=45nM, Kd=3.9e+2nM Q9BY41 15242608 1387 LVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV 3c10 A 2.0 BS03 TSN A 1 H669 H670 F679 D707 H709 F738 L810 H152 H153 F162 D190 H192 F221 L293 3.5.1.-,3.5.1.98 ic50=0.3uM -logKd/Ki=6.52, IC50=0.3uM IC50=22nM, Ki=195nM Q8WUI4 18285338 301 TLPFTTGLIYDSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLDNGKLAGLLAQVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSKYWGCMQR 3c10 B 2.0 BS03 TSN B 1 H669 H670 F679 D707 H709 L810 H136 H137 F146 D174 H176 L277 3.5.1.-,3.5.1.98 ic50=0.3uM IC50=22nM, Ki=195nM Q8WUI4 18285338 301 LPFTTGLIYDSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSKYWGCMQRL 3c10 C 2.0 BS03 TSN C 1 D626 H669 H670 F679 D707 H709 F738 L810 D86 H129 H130 F139 D167 H169 F198 L270 3.5.1.-,3.5.1.98 ic50=0.3uM IC50=22nM, Ki=195nM Q8WUI4 18285338 301 TTGLIYDSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSKYWGCMQ 3f0r A 2.54 BS02 TSN A 1 I34 P35 R37 W141 P273 Y306 I20 P21 R23 W127 P259 Y292 3.5.1.-,3.5.1.98 0000118,0000122,0000228,0004407,0005515,0005634,0005654,0005694,0005737,0006325,0007064,0016787,0030544,0031397,0031647,0032204,0033558,0040029,0046872,0051879,0140297,0160008,0160009 -logKd/Ki=6.89, Ki=130nM IC50=90nM, Ki=45nM, Kd=3.9e+2nM Q9BY41 19053282 800 SLVPVYIYSPEYVSMCDSLIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVVI 3f0r A 2.54 BS03 TSN A 2 Y100 H143 F152 D178 H180 Y306 Y86 H129 F138 D164 H166 Y292 3.5.1.-,3.5.1.98 0000118,0000122,0000228,0004407,0005515,0005634,0005654,0005694,0005737,0006325,0007064,0016787,0030544,0031397,0031647,0032204,0033558,0040029,0046872,0051879,0140297,0160008,0160009 -logKd/Ki=6.89, Ki=130nM IC50=90nM, Ki=45nM, Kd=3.9e+2nM Q9BY41 19053282 801 SLVPVYIYSPEYVSMCDSLIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVVI 3f0r B 2.54 BS02 TSN B 1 Y100 H143 F152 D178 H180 M274 Y306 Y88 H131 F140 D166 H168 M262 Y294 3.5.1.-,3.5.1.98 0000118,0000122,0000228,0004407,0005515,0005634,0005654,0005694,0005737,0006325,0007064,0016787,0030544,0031397,0031647,0032204,0033558,0040029,0046872,0051879,0140297,0160008,0160009 IC50=90nM, Ki=45nM, Kd=3.9e+2nM Q9BY41 19053282 804 SLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVVI 3f0r B 2.54 BS03 TSN B 2 P35 Y111 W141 P273 Y306 P23 Y99 W129 P261 Y294 3.5.1.-,3.5.1.98 0000118,0000122,0000228,0004407,0005515,0005634,0005654,0005694,0005737,0006325,0007064,0016787,0030544,0031397,0031647,0032204,0033558,0040029,0046872,0051879,0140297,0160008,0160009 IC50=90nM, Ki=45nM, Kd=3.9e+2nM Q9BY41 19053282 805 SLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVVI 3f0r C 2.54 BS02 TSN C 1 K33 Y100 H143 F152 D178 H180 Y306 K21 Y78 H121 F130 D156 H158 Y284 3.5.1.-,3.5.1.98 0000118,0000122,0000228,0004407,0005515,0005634,0005654,0005694,0005737,0006325,0007064,0016787,0030544,0031397,0031647,0032204,0033558,0040029,0046872,0051879,0140297,0160008,0160009 IC50=90nM, Ki=45nM, Kd=3.9e+2nM Q9BY41 19053282 802 SLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV 3f0r C 2.54 BS03 TSN C 2 P35 R37 W141 F152 P273 M274 Y306 P23 R25 W119 F130 P251 M252 Y284 3.5.1.-,3.5.1.98 0000118,0000122,0000228,0004407,0005515,0005634,0005654,0005694,0005737,0006325,0007064,0016787,0030544,0031397,0031647,0032204,0033558,0040029,0046872,0051879,0140297,0160008,0160009 IC50=90nM, Ki=45nM, Kd=3.9e+2nM Q9BY41 19053282 803 SLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV 4qa3 A 2.876 BS01 TSN A 1 H143 F152 D178 H180 F208 Y306 H130 F139 D165 H167 F195 Y293 3.5.1.-,3.5.1.98 0000118,0000122,0000228,0004407,0005515,0005634,0005654,0005694,0005737,0006325,0007064,0016787,0030544,0031397,0031647,0032204,0033558,0040029,0046872,0051879,0140297,0160008,0160009 IC50=90nM, Ki=45nM, Kd=3.9e+2nM Q9BY41 25075551 501 LVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANMARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVVI 4qa3 A 2.876 BS03 TSN B 1 P273 M274 Y306 P260 M261 Y293 3.5.1.-,3.5.1.98 0000118,0000122,0000228,0004407,0005515,0005634,0005654,0005694,0005737,0006325,0007064,0016787,0030544,0031397,0031647,0032204,0033558,0040029,0046872,0051879,0140297,0160008,0160009 IC50=90nM, Ki=45nM, Kd=3.9e+2nM Q9BY41 25075551 404 LVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANMARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVVI 4qa3 B 2.876 BS01 TSN A 1 P273 M274 Y306 P258 M259 Y291 3.5.1.-,3.5.1.98 0000118,0000122,0000228,0004407,0005515,0005634,0005654,0005694,0005737,0006325,0007064,0016787,0030544,0031397,0031647,0032204,0033558,0040029,0046872,0051879,0140297,0160008,0160009 IC50=90nM, Ki=45nM, Kd=3.9e+2nM Q9BY41 25075551 501 LVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANMARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV 4qa3 B 2.876 BS03 TSN B 1 H143 F152 D178 H180 F208 Y306 H128 F137 D163 H165 F193 Y291 3.5.1.-,3.5.1.98 0000118,0000122,0000228,0004407,0005515,0005634,0005654,0005694,0005737,0006325,0007064,0016787,0030544,0031397,0031647,0032204,0033558,0040029,0046872,0051879,0140297,0160008,0160009 IC50=90nM, Ki=45nM, Kd=3.9e+2nM Q9BY41 25075551 404 LVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANMARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV 5d1b A 2.9 BS02 TSN A 1 H143 F152 D178 H180 Y306 H122 F131 D157 H159 Y285 3.5.1.-,3.5.1.98 0000118,0000122,0000228,0004407,0005515,0005634,0005654,0005694,0005737,0006325,0007064,0016787,0030544,0031397,0031647,0032204,0033558,0040029,0046872,0051879,0140297,0160008,0160009 IC50=90nM, Ki=45nM, Kd=3.9e+2nM Q9BY41 26463496 404 LVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGEYGLGYDCPATEGIFDYAAAIGEATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV 5d1b A 2.9 BS03 TSN B 1 M274 Y306 M253 Y285 3.5.1.-,3.5.1.98 0000118,0000122,0000228,0004407,0005515,0005634,0005654,0005694,0005737,0006325,0007064,0016787,0030544,0031397,0031647,0032204,0033558,0040029,0046872,0051879,0140297,0160008,0160009 IC50=90nM, Ki=45nM, Kd=3.9e+2nM Q9BY41 26463496 404 LVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGEYGLGYDCPATEGIFDYAAAIGEATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV 5d1b B 2.9 BS01 TSN A 1 P273 Y306 P260 Y293 3.5.1.-,3.5.1.98 0000118,0000122,0000228,0004407,0005515,0005634,0005654,0005694,0005737,0006325,0007064,0016787,0030544,0031397,0031647,0032204,0033558,0040029,0046872,0051879,0140297,0160008,0160009 IC50=90nM, Ki=45nM, Kd=3.9e+2nM Q9BY41 26463496 404 LVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGEATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVVI 5d1b B 2.9 BS03 TSN B 1 H143 F152 D178 H180 M274 Y306 H130 F139 D165 H167 M261 Y293 3.5.1.-,3.5.1.98 0000118,0000122,0000228,0004407,0005515,0005634,0005654,0005694,0005737,0006325,0007064,0016787,0030544,0031397,0031647,0032204,0033558,0040029,0046872,0051879,0140297,0160008,0160009 IC50=90nM, Ki=45nM, Kd=3.9e+2nM Q9BY41 26463496 404 LVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGEATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVVI 5edu A 2.79 BS04 TSN A 1 P501 H610 H611 F620 H651 F680 Y782 P386 H495 H496 F505 H536 F565 Y667 3.5.1.-,3.5.1.98 0005515,0006974,0008643,0015144,0015768,0016020,0030288,0034219,0034289,0042597,0042956,0043190,0055052,0055085,0060326,1901982,1990060 P0AEX9,Q9UBN7 27454933 904 KLVIWINGDKGYNGLAEVGKKFEKGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDAALAAAQTNAAASRTGLVYDQNMMNHCNLWDSHHPEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTRELHRESSNFDSIYICPSTFACAQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVAVAARHAQTISGHALRILIVDWDVHHGNGTQHMFEDDPSVLYVSLHRYDHGTFFPMGDEGASSQIGRAAGTGFTVNVAWNGPRMGDADYLAAWHRLVLPIAYEFNPELVLVSAGFDAARGDPLGGCQVSPEGYAHLTHLLMGLASGRIILILEGGYNLTSISESMAACTRSLLGDPPPLLTLPRPPLSGALASITETIQVHRRYWRSLR 5edu B 2.79 BS03 TSN B 1 H500 P501 H610 H611 F620 D649 H651 F680 Y782 H390 P391 H500 H501 F510 D539 H541 F570 Y672 3.5.1.-,3.5.1.98 0005515,0006974,0008643,0015144,0015768,0016020,0030288,0034219,0034289,0042597,0042956,0043190,0055052,0055085,0060326,1901982,1990060 -logKd/Ki=8.66, Ki=2.2nM P0AEX9,Q9UBN7 27454933 2501 EEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDAALAAAQTNAAASRTGLVYDQNMMNHCNLWDSHHPEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTRELHRESSNFDSIYICPSTFACAQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVAVAARHAQTISGHALRILIVDWDVHHGNGTQHMFEDDPSVLYVSLHRYDHGTFFPMGDEGASSQIGRAAGTGFTVNVAWNGPRMGDADYLAAWHRLVLPIAYEFNPELVLVSAGFDAARGDPLGGCQVSPEGYAHLTHLLMGLASGRIILILEGGYNLTSISESMAACTRSLLGDPPPLLTRPPLSGALASITETIQVHRRYWRSLR 5eef A 2.151 BS02 TSN A 1 S150 H192 H193 F202 D230 H232 W261 K330 Y363 S87 H129 H130 F139 D167 H169 W198 K267 Y300 ? -logKd/Ki=8.32, Ki=4.8nM F8W4B7 27454933 2002 SATGTGLVYVDAFTRFHSHPECPARVSTVMEMLETEGLLGRCVQVEARAVTEDELLLVHTKEYVELMKSTQNMTEEELKTLAEKYDSVYLHPGFFSSACLSVGSVLQLVDKVMTSQLRNGFSINRPPGHHAQADKMNGFCMFNNLAIAARYAQKRHRVQRVLIVDWDVHHGQGIQYIFEEDPSVLYFSVHRYEDGSFWPHLKESDSSSVGSGAGQGYNINLPWNKVGMESGDYITAFQQLLLPVAYEFQPQLVLVAAGFDAVIGDPKGGMQVSPECFSILTHMLKGVAQGRLVLALEGGYNLQSTAEGVCASMRSLLGDPCPHLPSSGAPCESALKSISKTISDLYPFWKSLQT 5eef B 2.151 BS02 TSN B 1 S150 H192 H193 F202 D230 H232 W261 K330 Y363 S93 H135 H136 F145 D173 H175 W204 K273 Y306 ? F8W4B7 27454933 2002 GSATGTGLVYVDAFTRFHCLWDASHPECPARVSTVMEMLETEGLLGRCVQVEARAVTEDELLLVHTKEYVELMKSTQNMTEEELKTLAEKYDSVYLHPGFFSSACLSVGSVLQLVDKVMTSQLRNGFSINRPPGHHAQADKMNGFCMFNNLAIAARYAQKRHRVQRVLIVDWDVHHGQGIQYIFEEDPSVLYFSVHRYEDGSFWPHLKESDSSSVGSGAGQGYNINLPWNKVGMESGDYITAFQQLLLPVAYEFQPQLVLVAAGFDAVIGDPKGGMQVSPECFSILTHMLKGVAQGRLVLALEGGYNLQSTAEGVCASMRSLLGDPCPHLPSSGAPCESALKSISKTISDLYPFWKSLQT 5eek A 1.59 BS02 TSN A 1 P464 H573 H574 F583 D612 H614 F643 L712 Y745 P24 H133 H134 F143 D172 H174 F203 L272 Y305 3.5.1.98 -logKd/Ki=9.10, Ki=0.8nM F8W4B7 27454933 2004 SPITGLVYDQRMMLHHNMWDSHHPELPQRISRIFSRHEELRLLSRCHRIPARLATEEELALCHSSKHISIIKSSEHMKPRDLNRLGDEYNSIFISNESYTCALLAAGSCFNSAQAILTGQVRNAVAIVRPPGHHAEKDTACGFCFFNTAALTARYAQSITRESLRVLIVDWDVHHGNGTQHIFEEDDSVLYISLHRYEDGAFFPNSEDANYDKVGLGKGRGYNVNIPWNGGKMGDPEYMAAFHHLVMPIAREFAPELVLVSAGFDAARGDPLGGFQVTPEGYAHLTHQLMSLAAGRVLIILEGGYNLTSISESMSMCTSMLLGDSPPSLLTPLKTSATVSINNVLRAHAPFWSSLR 5g0g A 1.499 BS02 TSN A 1 W78 S150 H192 H193 F202 D230 H232 W261 K330 Y363 W20 S92 H134 H135 F144 D172 H174 W203 K272 Y305 ? ic50=5.45nM F8W4B7 27454931 1427 KATGTGLVYVDAFTRFHCLWDASHPECPARVSTVMEMLETEGLLGRCVQVEARAVTEDELLLVHTKEYVELMKSTQNMTEEELKTLAEKYDSVYLHPGFFSSACLSVGSVLQLVDKVMTSQLRNGFSINRPPGHHAQADKMNGFCMFNNLAIAARYAQKRHRVQRVLIVDWDVHHGQGIQYIFEEDPSVLYFSVHRYEDGSFWPHLKESDSSSVGSGAGQGYNINLPWNKVGMESGDYITAFQQLLLPVAYEFQPQLVLVAAGFDAVIGDPKGGMQVSPECFSILTHMLKGVAQGRLVLALEGGYNLQSTAEGVCASMRSLLGDPCPHLPSSGAPCESALKSISKTISDLYPFWKSLQTF 5wgi A 1.05 BS02 TSN A 1 P464 H573 H574 F583 D612 H614 L712 Y745 P29 H138 H139 F148 D177 H179 L277 Y310 ? F8W4B7 29203661 802 NAGGSSPITGLVYDQRMMLHHNMWDSHHPELPQRISRIFSRHEELRLLSRCHRIPARLATEEELALCHSSKHISIIKSSEHMKPRDLNRLGDEYNSIFISNESYTCALLAAGSCFNSAQAILTGQVRNAVAIVRPPGHHAEKDTACGFCFFNTAALTARYAQSITRESLRVLIVDWDVHHGNGTQHIFEEDDSVLYISLHRYEDGAFFPNSEDANYDKVGLGKGRGYNVNIPWNGGKMGDPEYMAAFHHLVMPIAREFAPELVLVSAGFDAARGDPLGGFQVTPEGYAHLTHQLMSLAAGRVLIILEGGYNLTSISESMSMCTSMLLGDSPPSLTPLKTSATVSINNVLRAHAPFWSSLR 6hoy A 1.7 BS03 TSN A 1 A53 S56 F64 V70 W71 N114 D116 A44 S47 F55 V61 W62 N105 D107 P62 D63 F64 R65 N114 D116 H133 P53 D54 F55 R56 N105 D107 H124 2.3.1.-,2.3.1.286,2.4.2.- 0070403 Kd=33uM -logKd/Ki=4.48, Kd=33uM Kd=33000nM, Ki=2000nM Q8N6T7 30395713 409 PFTADKGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVACRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVMTRLMKHLGLEIPAWDGPRVLERALPPLPRPPTPKL 6hoy B 1.7 BS03 TSN B 1 S56 F64 V70 W71 N114 V115 D116 S42 F50 V56 W57 N100 V101 D102 P62 D63 F64 R65 N114 D116 H133 P48 D49 F50 R51 N100 D102 H119 2.3.1.-,2.3.1.286,2.4.2.- 0070403 Kd=33uM Kd=33000nM, Ki=2000nM Q8N6T7 30395713 709 KGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVACRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVMTRLMKHLGLEIPAWDGPRVLERALPPLPRPPTPKL 6uo2 A 1.65002 BS02 TSN A 1 S150 H192 H193 F202 D230 H232 W261 Y363 S90 H132 H133 F142 D170 H172 W201 Y303 ? F8W4B7 31755702 504 TGTGLVYVDAFTRFHCLWDASHPECPARVSTVMEMLETEGLLGRCVQVEARAVTEDELLLVHTKEYVELMKSTQNMTEEELKTLAEKYDSVYLHPGFFSSACLSVGSVLQLVDKVMTSQLRNGFSINRPPGHHAQADKMNGFCMFNNLAIAARYAQKRHRVQRVLIVDWDVHHGQGIQYIFEEDPSVLYFSVHRYEDGSFWPHLKESDSSSVGSGAGQGYNINLPWNKVGMESGDYITAFQQLLLPVAYEFQPQLVLVAAGFDAVIGDPKGGMQVSPECFSILTHMLKGVAQGRLVLALEGGYNLQSTAEGVCASMRSLLGDPCPHLPSSGAPCESALKSISKTISDLYPFWKSLQT 6uo2 A 1.65002 BS03 TSN B 1 G258 S259 H263 G198 S199 H203 ? F8W4B7 31755702 504 TGTGLVYVDAFTRFHCLWDASHPECPARVSTVMEMLETEGLLGRCVQVEARAVTEDELLLVHTKEYVELMKSTQNMTEEELKTLAEKYDSVYLHPGFFSSACLSVGSVLQLVDKVMTSQLRNGFSINRPPGHHAQADKMNGFCMFNNLAIAARYAQKRHRVQRVLIVDWDVHHGQGIQYIFEEDPSVLYFSVHRYEDGSFWPHLKESDSSSVGSGAGQGYNINLPWNKVGMESGDYITAFQQLLLPVAYEFQPQLVLVAAGFDAVIGDPKGGMQVSPECFSILTHMLKGVAQGRLVLALEGGYNLQSTAEGVCASMRSLLGDPCPHLPSSGAPCESALKSISKTISDLYPFWKSLQT 6uo2 B 1.65002 BS01 TSN A 1 G258 S259 H263 G198 S199 H203 ? F8W4B7 31755702 504 TGTGLVYVDAFTRFHCLWDASHPECPARVSTVMEMLETEGLLGRCVQVEARAVTEDELLLVHTKEYVELMKSTQNMTEEELKTLAEKYDSVYLHPGFFSSACLSVGSVLQLVDKVMTSQLRNGFSINRPPGHHAQADKMNGFCMFNNLAIAARYAQKRHRVQRVLIVDWDVHHGQGIQYIFEEDPSVLYFSVHRYEDGSFWPHLKESDSSSVGSGAGQGYNINLPWNKVGMESGDYITAFQQLLLPVAYEFQPQLVLVAAGFDAVIGDPKGGMQVSPECFSILTHMLKGVAQGRLVLALEGGYNLQSTAEGVCASMRSLLGDPCPHLPSSGAPCESALKSISKTISDLYPFWKSLQT 6uo2 B 1.65002 BS03 TSN B 1 W78 S150 H192 H193 F202 D230 H232 W261 Y363 W18 S90 H132 H133 F142 D170 H172 W201 Y303 ? F8W4B7 31755702 504 TGTGLVYVDAFTRFHCLWDASHPECPARVSTVMEMLETEGLLGRCVQVEARAVTEDELLLVHTKEYVELMKSTQNMTEEELKTLAEKYDSVYLHPGFFSSACLSVGSVLQLVDKVMTSQLRNGFSINRPPGHHAQADKMNGFCMFNNLAIAARYAQKRHRVQRVLIVDWDVHHGQGIQYIFEEDPSVLYFSVHRYEDGSFWPHLKESDSSSVGSGAGQGYNINLPWNKVGMESGDYITAFQQLLLPVAYEFQPQLVLVAAGFDAVIGDPKGGMQVSPECFSILTHMLKGVAQGRLVLALEGGYNLQSTAEGVCASMRSLLGDPCPHLPSSGAPCESALKSISKTISDLYPFWKSLQT 6uo4 A 1.26831 BS02 TSN A 1 S150 H192 H193 F202 D230 H232 W261 S91 H133 H134 F143 D171 H173 W202 ? F8W4B7 31755702 504 ATGTGLVYVDAFTRFHCLWDASHPECPARVSTVMEMLETEGLLGRCVQVEARAVTEDELLLVHTKEYVELMKSTQNMTEEELKTLAEKYDSVYLHPGFFSSACLSVGSVLQLVDKVMTSQLRNGFSINRPPGHHAQADKMNGFCMFNNLAIAARYAQKRHRVQRVLIVDWDVHHGQGIQYIFEEDPSVLYFSVHRYEDGSFWPHLKESDSSSVGSGAGQGYNINLPWNKVGMESGDYITAFQQLLLPVAYEFQPQLVLVAAGFDAVIGDPKGGMQVSPECFSILTHMLKGVAQGRLVLALEGGFNLQSTAEGVCASMRSLLGDPCPHLPSSGAPCESALKSISKTISDLYPFWKSLQ 6uo4 A 1.26831 BS03 TSN B 1 G258 S259 H263 G199 S200 H204 ? F8W4B7 31755702 504 ATGTGLVYVDAFTRFHCLWDASHPECPARVSTVMEMLETEGLLGRCVQVEARAVTEDELLLVHTKEYVELMKSTQNMTEEELKTLAEKYDSVYLHPGFFSSACLSVGSVLQLVDKVMTSQLRNGFSINRPPGHHAQADKMNGFCMFNNLAIAARYAQKRHRVQRVLIVDWDVHHGQGIQYIFEEDPSVLYFSVHRYEDGSFWPHLKESDSSSVGSGAGQGYNINLPWNKVGMESGDYITAFQQLLLPVAYEFQPQLVLVAAGFDAVIGDPKGGMQVSPECFSILTHMLKGVAQGRLVLALEGGFNLQSTAEGVCASMRSLLGDPCPHLPSSGAPCESALKSISKTISDLYPFWKSLQ 6uo4 B 1.26831 BS01 TSN A 1 D257 G258 S259 H263 D197 G198 S199 H203 ? F8W4B7 31755702 504 TGTGLVYVDAFTRFHCLWDASHPECPARVSTVMEMLETEGLLGRCVQVEARAVTEDELLLVHTKEYVELMKSTQNMTEEELKTLAEKYDSVYLHPGFFSSACLSVGSVLQLVDKVMTSQLRNGFSINRPPGHHAQADKMNGFCMFNNLAIAARYAQKRHRVQRVLIVDWDVHHGQGIQYIFEEDPSVLYFSVHRYEDGSFWPHLKESDSSSVGSGAGQGYNINLPWNKVGMESGDYITAFQQLLLPVAYEFQPQLVLVAAGFDAVIGDPKGGMQVSPECFSILTHMLKGVAQGRLVLALEGGFNLQSTAEGVCASMRSLLGDPCPHLPSSGAPCESALKSISKTISDLYPFWKSLQT 6uo4 B 1.26831 BS03 TSN B 1 S150 H192 H193 F202 D230 H232 W261 S90 H132 H133 F142 D170 H172 W201 ? F8W4B7 31755702 504 TGTGLVYVDAFTRFHCLWDASHPECPARVSTVMEMLETEGLLGRCVQVEARAVTEDELLLVHTKEYVELMKSTQNMTEEELKTLAEKYDSVYLHPGFFSSACLSVGSVLQLVDKVMTSQLRNGFSINRPPGHHAQADKMNGFCMFNNLAIAARYAQKRHRVQRVLIVDWDVHHGQGIQYIFEEDPSVLYFSVHRYEDGSFWPHLKESDSSSVGSGAGQGYNINLPWNKVGMESGDYITAFQQLLLPVAYEFQPQLVLVAAGFDAVIGDPKGGMQVSPECFSILTHMLKGVAQGRLVLALEGGFNLQSTAEGVCASMRSLLGDPCPHLPSSGAPCESALKSISKTISDLYPFWKSLQT 6wyo A 2.3 BS02 TSN A 1 S150 H192 H193 Y202 D230 H232 W261 Y363 S80 H122 H123 Y132 D160 H162 W191 Y293 ? F8W4B7 32880591 504 TGTGLVYVFTRFFPCPARVSTVMEMLETEGLLGRCVQVEARAVTEDELLLVHTKEYVELMKSTQNMTEEELKTLAEKYDSVYLHPGFFSSACLSVGSVLQLVDKVMTSQLRNGFSINRPPGHHAQADKMNGYCMFNNLAIAARYAQKRHRVQRVLIVDWDVHHGQGIQYIFEEDPSVLYFSVHRYEDGSFWPHLKESDSSSVGSGAGQGYNINLPWNKVGMESGDYITAFQQLLLPVAYEFQPQLVLVAAGFDAVIGDPKGGMQVSPECFSILTHMLKGVAQGRLVLALEGGYNLQSTAEGVCASMRSLLGDPCPHLPSSGAPCESALKSISKTISDLYPFWKSLQT 6wyo A 2.3 BS03 TSN B 1 G258 S259 H263 G188 S189 H193 ? F8W4B7 32880591 504 TGTGLVYVFTRFFPCPARVSTVMEMLETEGLLGRCVQVEARAVTEDELLLVHTKEYVELMKSTQNMTEEELKTLAEKYDSVYLHPGFFSSACLSVGSVLQLVDKVMTSQLRNGFSINRPPGHHAQADKMNGYCMFNNLAIAARYAQKRHRVQRVLIVDWDVHHGQGIQYIFEEDPSVLYFSVHRYEDGSFWPHLKESDSSSVGSGAGQGYNINLPWNKVGMESGDYITAFQQLLLPVAYEFQPQLVLVAAGFDAVIGDPKGGMQVSPECFSILTHMLKGVAQGRLVLALEGGYNLQSTAEGVCASMRSLLGDPCPHLPSSGAPCESALKSISKTISDLYPFWKSLQT 6wyo B 2.3 BS01 TSN A 1 G258 S259 H263 G198 S199 H203 ? F8W4B7 32880591 504 TGTGLVYVDAFTRFHCLWDASFPECPARVSTVMEMLETEGLLGRCVQVEARAVTEDELLLVHTKEYVELMKSTQNMTEEELKTLAEKYDSVYLHPGFFSSACLSVGSVLQLVDKVMTSQLRNGFSINRPPGHHAQADKMNGYCMFNNLAIAARYAQKRHRVQRVLIVDWDVHHGQGIQYIFEEDPSVLYFSVHRYEDGSFWPHLKESDSSSVGSGAGQGYNINLPWNKVGMESGDYITAFQQLLLPVAYEFQPQLVLVAAGFDAVIGDPKGGMQVSPECFSILTHMLKGVAQGRLVLALEGGYNLQSTAEGVCASMRSLLGDPCPHLPSSGAPCESALKSISKTISDLYPFWKSLQT 6wyo B 2.3 BS03 TSN B 1 S150 H192 H193 Y202 D230 H232 W261 K330 Y363 S90 H132 H133 Y142 D170 H172 W201 K270 Y303 ? F8W4B7 32880591 504 TGTGLVYVDAFTRFHCLWDASFPECPARVSTVMEMLETEGLLGRCVQVEARAVTEDELLLVHTKEYVELMKSTQNMTEEELKTLAEKYDSVYLHPGFFSSACLSVGSVLQLVDKVMTSQLRNGFSINRPPGHHAQADKMNGYCMFNNLAIAARYAQKRHRVQRVLIVDWDVHHGQGIQYIFEEDPSVLYFSVHRYEDGSFWPHLKESDSSSVGSGAGQGYNINLPWNKVGMESGDYITAFQQLLLPVAYEFQPQLVLVAAGFDAVIGDPKGGMQVSPECFSILTHMLKGVAQGRLVLALEGGYNLQSTAEGVCASMRSLLGDPCPHLPSSGAPCESALKSISKTISDLYPFWKSLQT