1ecm A 2.2 BS01 TSA A 1 R28 V35 K39 V46 R51 E52 S84 Q88 R24 V31 K35 V42 R47 E48 S80 Q84 4.2.1.51,5.4.99.5 0004106,0005737,0009094,0046417 Kd=2.8uM P0A9J8 500 NPLLALREKISALDEKLLALLAERRELAVEVGKAKLLSHRPVRDIDRERDLLERLITLGKAHHLDAHYITRLFQLIIEDSVLTQQALLQQH 1ecm B 2.2 BS01 TSA B 1 R28 V35 K39 R47 D48 R51 E52 I81 S84 Q88 R23 V30 K34 R42 D43 R46 E47 I76 S79 Q83 4.2.1.51,5.4.99.5 0004106,0005737,0009094,0046417 Kd=2.8uM P0A9J8 501 PLLALREKISALDEKLLALLAERRELAVEVGKAKLLSHRPVRDIDRERDLLERLITLGKAHHLDAHYITRLFQLIIEDSVLTQQALLQQHLNKIN 1fig H 3.0 BS01 TSA H 1 N33 R94 R95 Y100 F100B N33 R98 R99 Y104 F106 -logKd/Ki=6.22, Ki=0.6uM 8303271 224 DVQLQQSGPELEKPGASVKISCKASGFSLPGHNINWIVQRNGKSLEWIGNIDPYYGGTNFNPKFKGKATLTVDKSSSTLYMHLTSLQSEDSAVYYCARRRDGNYGFTYWGQGTLVTVSAAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKI 2cht A 2.2 BS01 TSA A 1 R7 R90 Y108 L115 R6 R89 Y107 L114 R7 R63 C75 E78 R90 Y108 R6 R62 C74 E77 R89 Y107 5.4.99.5 0004106,0005737,0008652,0009073,0016853,0046417 Ki=3uM P19080 8378335 203 MIRGIRGATTVERDTEEEILQKTKQLLEKIIEENHTKPEDVVQMLLSATPDLHAVFPAKAVRELSGWQYVPVTCMQEMDVTGGLKKCIRVMMTVQTDVPQDQIRHVYLEKAVVL 2cht A 2.2 BS02 TSA B 1 F57 A59 K60 R63 V73 T74 C75 F56 A58 K59 R62 V72 T73 C74 R7 R63 C75 E78 R90 Y108 R6 R62 C74 E77 R89 Y107 5.4.99.5 0004106,0005737,0008652,0009073,0016853,0046417 Ki=3uM P19080 8378335 201 MIRGIRGATTVERDTEEEILQKTKQLLEKIIEENHTKPEDVVQMLLSATPDLHAVFPAKAVRELSGWQYVPVTCMQEMDVTGGLKKCIRVMMTVQTDVPQDQIRHVYLEKAVVL 2cht B 2.2 BS01 TSA B 1 R7 E78 R90 Y108 L115 R6 E77 R89 Y107 L114 R7 R63 C75 E78 R90 Y108 R116 R6 R62 C74 E77 R89 Y107 R115 5.4.99.5 0004106,0005737,0008652,0009073,0016853,0046417 Ki=3uM P19080 8378335 201 MIRGIRGATTVERDTEEEILQKTKQLLEKIIEENHTKPEDVVQMLLSATPDLHAVFPAKAVRELSGWQYVPVTCMQEMDVTGGLKKCIRVMMTVQTDVPQDQIRHVYLEKAVVLRPD 2cht B 2.2 BS02 TSA C 1 F57 A59 V73 T74 C75 F56 A58 V72 T73 C74 R7 R63 C75 E78 R90 Y108 R116 R6 R62 C74 E77 R89 Y107 R115 5.4.99.5 0004106,0005737,0008652,0009073,0016853,0046417 Ki=3uM P19080 8378335 202 MIRGIRGATTVERDTEEEILQKTKQLLEKIIEENHTKPEDVVQMLLSATPDLHAVFPAKAVRELSGWQYVPVTCMQEMDVTGGLKKCIRVMMTVQTDVPQDQIRHVYLEKAVVLRPD 2cht C 2.2 BS01 TSA A 1 F57 A59 K60 R63 T74 C75 F56 A58 K59 R62 T73 C74 R7 R63 C75 E78 R90 Y108 R116 R6 R62 C74 E77 R89 Y107 R115 5.4.99.5 0004106,0005737,0008652,0009073,0016853,0046417 Ki=3uM P19080 8378335 203 MIRGIRGATTVERDTEEEILQKTKQLLEKIIEENHTKPEDVVQMLLSATPDLHAVFPAKAVRELSGWQYVPVTCMQEMDVTGGLKKCIRVMMTVQTDVPQDQIRHVYLEKAVVLRPDL 2cht C 2.2 BS02 TSA C 1 R7 E78 R90 Y108 L115 R6 E77 R89 Y107 L114 R7 R63 C75 E78 R90 Y108 R116 R6 R62 C74 E77 R89 Y107 R115 5.4.99.5 0004106,0005737,0008652,0009073,0016853,0046417 Ki=3uM P19080 8378335 202 MIRGIRGATTVERDTEEEILQKTKQLLEKIIEENHTKPEDVVQMLLSATPDLHAVFPAKAVRELSGWQYVPVTCMQEMDVTGGLKKCIRVMMTVQTDVPQDQIRHVYLEKAVVLRPDL 2cht D 2.2 BS01 TSA D 1 R7 E78 R90 Y108 R6 E77 R89 Y107 R7 R63 C75 E78 R90 Y108 R6 R62 C74 E77 R89 Y107 5.4.99.5 0004106,0005737,0008652,0009073,0016853,0046417 Ki=3uM P19080 8378335 206 MIRGIRGATTVERDTEEEILQKTKQLLEKIIEENHTKPEDVVQMLLSATPDLHAVFPAKAVRELSGWQYVPVTCMQEMDVTGGLKKCIRVMMTVQTDVPQDQIRHVYLEKAVVL 2cht D 2.2 BS02 TSA E 1 F57 A59 R63 T74 C75 F56 A58 R62 T73 C74 R7 R63 C75 E78 R90 Y108 R6 R62 C74 E77 R89 Y107 5.4.99.5 0004106,0005737,0008652,0009073,0016853,0046417 Ki=3uM P19080 8378335 204 MIRGIRGATTVERDTEEEILQKTKQLLEKIIEENHTKPEDVVQMLLSATPDLHAVFPAKAVRELSGWQYVPVTCMQEMDVTGGLKKCIRVMMTVQTDVPQDQIRHVYLEKAVVL 2cht E 2.2 BS01 TSA E 1 R7 E78 R90 Y108 L115 R6 E77 R89 Y107 L114 R7 R63 C75 E78 R90 Y108 R116 R6 R62 C74 E77 R89 Y107 R115 5.4.99.5 0004106,0005737,0008652,0009073,0016853,0046417 Ki=3uM P19080 8378335 204 MIRGIRGATTVERDTEEEILQKTKQLLEKIIEENHTKPEDVVQMLLSATPDLHAVFPAKAVRELSGWQYVPVTCMQEMDVTGGLKKCIRVMMTVQTDVPQDQIRHVYLEKAVVLRPD 2cht E 2.2 BS02 TSA F 1 F57 A59 K60 V73 T74 C75 F56 A58 K59 V72 T73 C74 R7 R63 C75 E78 R90 Y108 R116 R6 R62 C74 E77 R89 Y107 R115 5.4.99.5 0004106,0005737,0008652,0009073,0016853,0046417 Ki=3uM P19080 8378335 205 MIRGIRGATTVERDTEEEILQKTKQLLEKIIEENHTKPEDVVQMLLSATPDLHAVFPAKAVRELSGWQYVPVTCMQEMDVTGGLKKCIRVMMTVQTDVPQDQIRHVYLEKAVVLRPD 2cht F 2.2 BS01 TSA D 1 F57 A59 K60 C75 F56 A58 K59 C74 R7 R63 C75 E78 R90 Y108 R116 R6 R62 C74 E77 R89 Y107 R115 5.4.99.5 0004106,0005737,0008652,0009073,0016853,0046417 Ki=3uM P19080 8378335 206 MIRGIRGATTVERDTEEEILQKTKQLLEKIIEENHTKPEDVVQMLLSATPDLHAVFPAKAVRELSGWQYVPVTCMQEMDVTGGLKKCIRVMMTVQTDVPQDQIRHVYLEKAVVLRPDL 2cht F 2.2 BS02 TSA F 1 R7 E78 R90 Y108 R6 E77 R89 Y107 R7 R63 C75 E78 R90 Y108 R116 R6 R62 C74 E77 R89 Y107 R115 5.4.99.5 0004106,0005737,0008652,0009073,0016853,0046417 Ki=3uM P19080 8378335 205 MIRGIRGATTVERDTEEEILQKTKQLLEKIIEENHTKPEDVVQMLLSATPDLHAVFPAKAVRELSGWQYVPVTCMQEMDVTGGLKKCIRVMMTVQTDVPQDQIRHVYLEKAVVLRPDL 2cht G 2.2 BS01 TSA G 1 R7 E78 R90 Y108 R6 E77 R89 Y107 R7 R63 C75 E78 R90 Y108 R116 R6 R62 C74 E77 R89 Y107 R115 5.4.99.5 0004106,0005737,0008652,0009073,0016853,0046417 Ki=3uM P19080 8378335 209 MIRGIRGATTVERDTEEEILQKTKQLLEKIIEENHTKPEDVVQMLLSATPDLHAVFPAKAVRELSGWQYVPVTCMQEMDVTGGLKKCIRVMMTVQTDVPQDQIRHVYLEKAVVLR 2cht G 2.2 BS02 TSA H 1 F57 A59 K60 C75 F56 A58 K59 C74 R7 R63 C75 E78 R90 Y108 R116 R6 R62 C74 E77 R89 Y107 R115 5.4.99.5 0004106,0005737,0008652,0009073,0016853,0046417 Ki=3uM P19080 8378335 207 MIRGIRGATTVERDTEEEILQKTKQLLEKIIEENHTKPEDVVQMLLSATPDLHAVFPAKAVRELSGWQYVPVTCMQEMDVTGGLKKCIRVMMTVQTDVPQDQIRHVYLEKAVVLR 2cht H 2.2 BS01 TSA H 1 R7 E78 R90 Y108 L115 R6 E77 R89 Y107 L114 R7 R63 C75 E78 R90 Y108 R116 R6 R62 C74 E77 R89 Y107 R115 5.4.99.5 0004106,0005737,0008652,0009073,0016853,0046417 Ki=3uM P19080 8378335 207 MIRGIRGATTVERDTEEEILQKTKQLLEKIIEENHTKPEDVVQMLLSATPDLHAVFPAKAVRELSGWQYVPVTCMQEMDVTGGLKKCIRVMMTVQTDVPQDQIRHVYLEKAVVLRP 2cht H 2.2 BS02 TSA I 1 F57 A59 K60 V73 T74 C75 F56 A58 K59 V72 T73 C74 R7 R63 C75 E78 R90 Y108 R116 R6 R62 C74 E77 R89 Y107 R115 5.4.99.5 0004106,0005737,0008652,0009073,0016853,0046417 Ki=3uM P19080 8378335 208 MIRGIRGATTVERDTEEEILQKTKQLLEKIIEENHTKPEDVVQMLLSATPDLHAVFPAKAVRELSGWQYVPVTCMQEMDVTGGLKKCIRVMMTVQTDVPQDQIRHVYLEKAVVLRP 2cht I 2.2 BS01 TSA G 1 F57 A59 V73 T74 C75 F56 A58 V72 T73 C74 R7 R63 C75 E78 R90 Y108 R6 R62 C74 E77 R89 Y107 5.4.99.5 0004106,0005737,0008652,0009073,0016853,0046417 Ki=3uM P19080 8378335 209 MIRGIRGATTVERDTEEEILQKTKQLLEKIIEENHTKPEDVVQMLLSATPDLHAVFPAKAVRELSGWQYVPVTCMQEMDVTGGLKKCIRVMMTVQTDVPQDQIRHVYLEKAVVL 2cht I 2.2 BS02 TSA I 1 R7 E78 R90 Y108 L115 R6 E77 R89 Y107 L114 R7 R63 C75 E78 R90 Y108 R6 R62 C74 E77 R89 Y107 5.4.99.5 0004106,0005737,0008652,0009073,0016853,0046417 Ki=3uM P19080 8378335 208 MIRGIRGATTVERDTEEEILQKTKQLLEKIIEENHTKPEDVVQMLLSATPDLHAVFPAKAVRELSGWQYVPVTCMQEMDVTGGLKKCIRVMMTVQTDVPQDQIRHVYLEKAVVL 2cht J 2.2 BS01 TSA J 1 R7 E78 R90 Y108 R6 E77 R89 Y107 R7 R63 C75 E78 R90 Y108 R116 R6 R62 C74 E77 R89 Y107 R115 5.4.99.5 0004106,0005737,0008652,0009073,0016853,0046417 Ki=3uM P19080 8378335 212 MIRGIRGATTVERDTEEEILQKTKQLLEKIIEENHTKPEDVVQMLLSATPDLHAVFPAKAVRELSGWQYVPVTCMQEMDVTGGLKKCIRVMMTVQTDVPQDQIRHVYLEKAVVLRPD 2cht J 2.2 BS02 TSA K 1 F57 A59 K60 V73 T74 C75 F56 A58 K59 V72 T73 C74 R7 R63 C75 E78 R90 Y108 R116 R6 R62 C74 E77 R89 Y107 R115 5.4.99.5 0004106,0005737,0008652,0009073,0016853,0046417 Ki=3uM P19080 8378335 210 MIRGIRGATTVERDTEEEILQKTKQLLEKIIEENHTKPEDVVQMLLSATPDLHAVFPAKAVRELSGWQYVPVTCMQEMDVTGGLKKCIRVMMTVQTDVPQDQIRHVYLEKAVVLRPD 2cht K 2.2 BS01 TSA K 1 R7 E78 R90 Y108 L115 R116 R6 E77 R89 Y107 L114 R115 R7 R63 C75 E78 R90 Y108 R116 R6 R62 C74 E77 R89 Y107 R115 5.4.99.5 0004106,0005737,0008652,0009073,0016853,0046417 Ki=3uM P19080 8378335 210 MIRGIRGATTVERDTEEEILQKTKQLLEKIIEENHTKPEDVVQMLLSATPDLHAVFPAKAVRELSGWQYVPVTCMQEMDVTGGLKKCIRVMMTVQTDVPQDQIRHVYLEKAVVLRPD 2cht K 2.2 BS02 TSA L 1 F57 A59 V73 T74 C75 F56 A58 V72 T73 C74 R7 R63 C75 E78 R90 Y108 R116 R6 R62 C74 E77 R89 Y107 R115 5.4.99.5 0004106,0005737,0008652,0009073,0016853,0046417 Ki=3uM P19080 8378335 211 MIRGIRGATTVERDTEEEILQKTKQLLEKIIEENHTKPEDVVQMLLSATPDLHAVFPAKAVRELSGWQYVPVTCMQEMDVTGGLKKCIRVMMTVQTDVPQDQIRHVYLEKAVVLRPD 2cht L 2.2 BS01 TSA J 1 F57 A59 K60 C75 F56 A58 K59 C74 R7 R63 C75 E78 R90 Y108 R6 R62 C74 E77 R89 Y107 5.4.99.5 0004106,0005737,0008652,0009073,0016853,0046417 Ki=3uM P19080 8378335 212 MIRGIRGATTVERDTEEEILQKTKQLLEKIIEENHTKPEDVVQMLLSATPDLHAVFPAKAVRELSGWQYVPVTCMQEMDVTGGLKKCIRVMMTVQTDVPQDQIRHVYLEKAVVL 2cht L 2.2 BS02 TSA L 1 R7 E78 R90 Y108 R6 E77 R89 Y107 R7 R63 C75 E78 R90 Y108 R6 R62 C74 E77 R89 Y107 5.4.99.5 0004106,0005737,0008652,0009073,0016853,0046417 Ki=3uM P19080 8378335 211 MIRGIRGATTVERDTEEEILQKTKQLLEKIIEENHTKPEDVVQMLLSATPDLHAVFPAKAVRELSGWQYVPVTCMQEMDVTGGLKKCIRVMMTVQTDVPQDQIRHVYLEKAVVL 2fp2 B 1.64 BS01 TSA B 1 R49 K60 I67 E68 D69 R72 Q76 I102 T105 E106 E109 R134 R13 K24 I31 E32 D33 R36 Q40 I66 T69 E70 E73 R98 R49 K60 D69 T105 E106 E109 R134 R13 K24 D33 T69 E70 E73 R98 5.4.99.5 0004106,0005515,0005576,0009697,0016853,0046417 P9WIB9 16499927 500 SQLAELVDAAAERLEVADPVAAFKWRAQLPIEDSGRVEQQLAKLGEDARSQHIDPDYVTRVFDDQIRATEAIEYSRFSDWKLNPASAPPEPPDLSASRSAIDSLNNRMLSQIWSHWSLLSAPSCAAQLDRAKRDIVRSRHLDSLYQRALTTATQSYCQALPPA 2gtv X -1.00 BS01 TSA X 1 R9 R34 V41 K45 D54 R57 E58 N90 Q94 R9 R34 V41 K45 D54 R57 E58 N90 Q94 5.4.99.5 0046417 -logKd/Ki=5.15, Kd=7uM Q57696 17994104 501 MIEKLAEIRKKIDEIDNKILKARWPWAEKLIAERNSLAKDVAEIKNQLGIPINDPEREKYIYDRIRKLCKEHNVDENIGIKIFQRLIEHNKALQKQYLEETLEH 2w1a C 2.35 BS01 TSA C 1 R35 S39 I42 R46 L54 V55 R58 E59 L81 R23 S27 I30 R34 L42 V43 R46 E47 L69 5.4.99.5 0046417 P9WIC1 19556970 1091 EIDTLREEIDRLDAEILALVKRRAEVSKAIGKARMASGGTRLVHSREMKVIERYSELGPDGKDLAILLLRLGRGRLGH 2w1a D 2.35 BS01 TSA D 1 R35 S39 I42 R46 L54 V55 R58 E59 L81 R24 S28 I31 R35 L43 V44 R47 E48 L70 5.4.99.5 0046417 P9WIC1 19556970 1091 PEIDTLREEIDRLDAEILALVKRRAEVSKAIGKARMASGGTRLVHSREMKVIERYSELGPDGKDLAILLLRLGRGRLGH 3csm A 3.0 BS02 TSA A 1 R16 R157 K168 I192 T193 E198 I239 K243 E246 R16 R157 K168 I192 T193 E198 I235 K239 E242 R16 R157 K168 N194 E198 T242 E246 R16 R157 K168 N194 E198 T238 E242 5.4.99.5 0004106,0005515,0005634,0005737,0006571,0009073,0009094,0016853,0046417,0072545,0120284 P32178 9384560 400 MDFTKPETVLNLQNIRDELVRMEDSIIFKFIERSHFATCPSVYEANHPGLEIPNFKGSFLDWALSNLEIAHSRIRRFESPDETPFFPDKIQKSFLPSINYPQILAPYAPEVNYNDKIKKVYIEKIIPLISKRDGDDKNNFGSVATRDIECLQSLSRRIHFGKFVAEAKFQSDIPLYTKLIKSKDVEGIMKNITNSAVEEKILERLTKKAEVYGVDPTERRITPEYLVKIYKEIVIPITKEVEVEYLLRRLEE 3csm B 3.0 BS02 TSA B 1 R16 R157 K168 I192 T193 E198 I239 K243 E246 R16 R157 K168 I192 T193 E198 I235 K239 E242 R16 R157 K168 N194 E198 T242 E246 R16 R157 K168 N194 E198 T238 E242 5.4.99.5 0004106,0005515,0005634,0005737,0006571,0009073,0009094,0016853,0046417,0072545,0120284 P32178 9384560 400 MDFTKPETVLNLQNIRDELVRMEDSIIFKFIERSHFATCPSVYEANHPGLEIPNFKGSFLDWALSNLEIAHSRIRRFESPDETPFFPDKIQKSFLPSINYPQILAPYAPEVNYNDKIKKVYIEKIIPLISKRDGDDKNNFGSVATRDIECLQSLSRRIHFGKFVAEAKFQSDIPLYTKLIKSKDVEGIMKNITNSAVEEKILERLTKKAEVYGVDPTERRITPEYLVKIYKEIVIPITKEVEVEYLLRRLEE 3zp4 A 1.798 BS01 TSA C 1 R7 E78 X90 R7 E78 X90 R7 R63 C75 E78 Y108 R116 R7 R63 C75 E78 Y107 R115 5.4.99.5 0004106,0005737,0008652,0009073,0016853,0046417 P19080 25422475 1118 MMIRGIRGATTVERDTEEEILQKTKQLLEKIIEENHTKPEDVVQMLLSATPDLHAVFPAKAVRELSGWQYVPVTCMQEMDVTGGLKKCIRVMMTVQTDVPQEQIRHVYLEKAVVLRP 3zp4 B 1.798 BS01 TSA B 1 F57 A59 V73 T74 C75 F57 A59 V73 T74 C75 R7 R63 C75 E78 Y108 R116 R7 R63 C75 E78 Y107 R115 5.4.99.5 0004106,0005737,0008652,0009073,0016853,0046417 P19080 25422475 1118 MMIRGIRGATTVERDTEEEILQKTKQLLEKIIEENHTKPEDVVQMLLSATPDLHAVFPAKAVRELSGWQYVPVTCMQEMDVTGGLKKCIRVMMTVQTDVPQEQIRHVYLEKAVVLRP 3zp4 C 1.798 BS01 TSA B 1 R7 E78 X90 Y108 L115 R7 E78 X90 Y108 L115 R7 R63 C75 E78 Y108 R116 R7 R63 C75 E78 Y107 R115 5.4.99.5 0004106,0005737,0008652,0009073,0016853,0046417 P19080 25422475 1118 MMIRGIRGATTVERDTEEEILQKTKQLLEKIIEENHTKPEDVVQMLLSATPDLHAVFPAKAVRELSGWQYVPVTCMQEMDVTGGLKKCIRVMMTVQTDVPQEQIRHVYLEKAVVLRP 3zp4 C 1.798 BS02 TSA C 1 F57 A59 R63 T74 C75 F57 A59 R63 T74 C75 R7 R63 C75 E78 Y108 R116 R7 R63 C75 E78 Y107 R115 5.4.99.5 0004106,0005737,0008652,0009073,0016853,0046417 P19080 25422475 1118 MMIRGIRGATTVERDTEEEILQKTKQLLEKIIEENHTKPEDVVQMLLSATPDLHAVFPAKAVRELSGWQYVPVTCMQEMDVTGGLKKCIRVMMTVQTDVPQEQIRHVYLEKAVVLRP 3zp4 D 1.798 BS01 TSA D 1 F57 A59 R63 V73 T74 C75 F57 A59 R63 V73 T74 C75 R7 R63 C75 E78 Y108 R116 R7 R63 C75 E78 Y107 R115 5.4.99.5 0004106,0005737,0008652,0009073,0016853,0046417 P19080 25422475 1118 MMIRGIRGATTVERDTEEEILQKTKQLLEKIIEENHTKPEDVVQMLLSATPDLHAVFPAKAVRELSGWQYVPVTCMQEMDVTGGLKKCIRVMMTVQTDVPQEQIRHVYLEKAVVLRP 3zp4 D 1.798 BS02 TSA F 1 R7 E78 X90 Y108 L115 R7 E78 X90 Y108 L115 R7 R63 C75 E78 Y108 R116 R7 R63 C75 E78 Y107 R115 5.4.99.5 0004106,0005737,0008652,0009073,0016853,0046417 P19080 25422475 1118 MMIRGIRGATTVERDTEEEILQKTKQLLEKIIEENHTKPEDVVQMLLSATPDLHAVFPAKAVRELSGWQYVPVTCMQEMDVTGGLKKCIRVMMTVQTDVPQEQIRHVYLEKAVVLRP 3zp4 E 1.798 BS01 TSA D 1 R7 X90 L115 R7 X90 L115 R7 R63 C75 E78 Y108 R116 R7 R63 C75 E78 Y107 R115 5.4.99.5 0004106,0005737,0008652,0009073,0016853,0046417 P19080 25422475 1118 MMIRGIRGATTVERDTEEEILQKTKQLLEKIIEENHTKPEDVVQMLLSATPDLHAVFPAKAVRELSGWQYVPVTCMQEMDVTGGLKKCIRVMMTVQTDVPQEQIRHVYLEKAVVLRP 3zp4 F 1.798 BS01 TSA F 1 F57 A59 V73 C75 F57 A59 V73 C75 R7 R63 C75 E78 Y108 R116 R7 R63 C75 E78 Y107 R115 5.4.99.5 0004106,0005737,0008652,0009073,0016853,0046417 P19080 25422475 1118 MMIRGIRGATTVERDTEEEILQKTKQLLEKIIEENHTKPEDVVQMLLSATPDLHAVFPAKAVRELSGWQYVPVTCMQEMDVTGGLKKCIRVMMTVQTDVPQEQIRHVYLEKAVVLRP 4csm A 2.8 BS01 TSA A 1 R16 R157 K168 T193 N194 E198 I239 K243 E246 R16 R157 K168 T193 N194 E198 I235 K239 E242 R16 R157 K168 N194 E198 T242 E246 R16 R157 K168 N194 E198 T238 E242 5.4.99.5 0004106,0005515,0005634,0005737,0006571,0009073,0009094,0016853,0046417,0072545,0120284 P32178 9384560 400 MDFTKPETVLNLQNIRDELVRMEDSIIFKFIERSHFATCPSVYEANHPGLEIPNFKGSFLDWALSNLEIAHSRIRRFESPDETPFFPDKIQKSFLPSINYPQILAPYAPEVNYNDKIKKVYIEKIIPLISKRDGDDKNNFGSVATRDIECLQSLSRRIHFGKFVAEAKFQSDIPLYTKLIKSKDVEGIMKNITNSAVEEKILERLTKKAEVYGVDPTERRITPEYLVKIYKEIVIPITKEVEVEYLLRRLEE 4csm B 2.8 BS01 TSA B 1 R16 R157 K168 T193 N194 E198 I239 K243 E246 R16 R157 K168 T193 N194 E198 I235 K239 E242 R16 R157 K168 N194 E198 T242 E246 R16 R157 K168 N194 E198 T238 E242 5.4.99.5 0004106,0005515,0005634,0005737,0006571,0009073,0009094,0016853,0046417,0072545,0120284 P32178 9384560 400 MDFTKPETVLNLQNIRDELVRMEDSIIFKFIERSHFATCPSVYEANHPGLEIPNFKGSFLDWALSNLEIAHSRIRRFESPDETPFFPDKIQKSFLPSINYPQILAPYAPEVNYNDKIKKVYIEKIIPLISKRDGDDKNNFGSVATRDIECLQSLSRRIHFGKFVAEAKFQSDIPLYTKLIKSKDVEGIMKNITNSAVEEKILERLTKKAEVYGVDPTERRITPEYLVKIYKEIVIPITKEVEVEYLLRRLEE 5ckx C 2.7 BS01 TSA C 1 R35 S39 I42 R46 R58 E59 L81 R23 S27 I30 R34 R46 E47 L69 5.4.99.5 0046417 P9WIC1 26776476 102 EIDTLREEIDRLDAEILALVKRRAEVSKAIGKARMASGGTRLVHSREMKVIERYSELGPDGKDLAILLLRLGRGRLGH 5ckx D 2.7 BS01 TSA D 1 R35 S39 I42 R46 R58 E59 L81 R24 S28 I31 R35 R47 E48 L70 5.4.99.5 0046417 P9WIC1 26776476 103 PEIDTLREEIDRLDAEILALVKRRAEVSKAIGKARMASGGTRLVHSREMKVIERYSELGPDGKDLAILLLRLGRGRLGH 5hud E 2.15 BS01 TSA E 1 R35 S39 I42 R46 L54 V55 R58 E59 L82 R29 S33 I36 R40 L48 V49 R52 E53 L76 5.4.99.5 0046417 Q8NS29 29178787 108 DPLSDAEIQKYREEINRLDREILDAVKRRTKISQTIGKTRMSSGGTRLVHTREVAIINQFREEIGEEGPALAGILLRMGRGKLG 5hud F 2.15 BS01 TSA F 1 R35 S39 I42 R46 V55 R58 E59 L82 R86 R28 S32 I35 R39 V48 R51 E52 L75 R79 5.4.99.5 0046417 Q8NS29 29178787 110 PLSDAEIQKYREEINRLDREILDAVKRRTKISQTIGKTRMSSGGTRLVHTREVAIINQFREEIGEEGPALAGILLRMGRGKLG 5hud G 2.15 BS01 TSA G 1 R35 S39 I42 R46 L54 V55 R58 E59 L82 R28 S32 I35 R39 L47 V48 R51 E52 L75 5.4.99.5 0046417 Q8NS29 29178787 111 PLSDAEIQKYREEINRLDREILDAVKRRTKISQTIGKTRMSSGGTRLVHTREVAIINQFREEIGEEGPALAGILLRMGRGKLG 5hud H 2.15 BS01 TSA H 1 R35 S39 I42 R46 L54 V55 E59 L82 R86 R28 S32 I35 R39 L47 V48 E52 L75 R79 5.4.99.5 0046417 Q8NS29 29178787 106 PLSDAEIQKYREEINRLDREILDAVKRRTKISQTIGKTRMSSGGTRLVHTREVAIINQFREEIGEEGPALAGILLRMGRGKLG 8pnh A 1.9 BS01 TSA A 1 R276 K287 I294 R299 E300 Q336 R362 R246 K257 I264 R269 E270 Q306 R332 A0AAJ6N664 501 HRLDDITARGVLRVGTTGDYKPFSSRAGNDFVGLDIELAADLARTLGVPVQIVPTSWPTLMKDFGDGKFDIALGGVSITPERQKQGLFSVSYLRDGKTPITRCENSARFQTLAQIDQPGVRLVVNPGGTNERFARSQAPNAQLTVYPDNVTIFDQIVTGAADLMITDAIETRLQQRLRPQLCAVHPDTPFDFAEKAILLPRDVAFKAVVDKWLQQRIASGAVQRSVDRWLDFPWGLEPLRLAIDQRLLLAQAVARAKWNVQAPIEDLGREAQVIQAAVKEGAALGLPKVWIETVFRAQIEASKTVQRELFAQWSAQQAGKFDDAPDLAKTIRPELDRLTTQLLRSMASNQTVLNDEARKADVARAMRALEARALSPQAATQALAPF 8pnj A 2.355 BS01 TSA A 1 R37 M41 K48 I55 E56 D57 R60 E61 M88 Q95 R120 R14 M18 K25 I32 E33 D34 R37 E38 M65 Q72 R97 501 NHSEQTLYQLMSERLALMPEVAKYKWHHNLPIEDLAREAMVLERTVSRTTVLDPIHTKTFFGLQMTAAKAIQANVFQSLTNTDVVASDVRSLNDDLRPKLTLLGDQIIEQLLISYQNGTPLNRAHFDAHFAHFELNPQIKDGLFKSLELVLTPDPRDTLARLEKDKTLRVGVTLDYEPFSYQDNEGNRAGIDIELATALAKEFGYRIVWVKTSWPTLMADAEDNLFDIALSGISITAQRQHRMMFSAPYHTGGKTAIGRCSSVDELNTLALIDRAETRIIVNPGGTNERFVRSALTNASIRIHPDNRTIFNELVSGTADAMFTDSIEAQLQATKHPSLCVLLDQPLTFQQKGILLQPDPELKKRIDTWLLDYLSSHDVSALFSKHGVDPD