3hku A 1.8 BS02 TOR A 1 N62 A65 N67 Q92 H94 F130 L197 T198 T199 N59 A62 N64 Q89 H91 F127 L194 T195 T196 H64 H94 H96 E106 H119 T198 H61 H91 H93 E103 H116 T195 4.2.1.1,4.2.1.69 0002009,0004064,0004089,0005515,0005737,0005829,0005886,0006730,0008270,0015670,0016829,0018820,0032230,0032849,0038166,0043209,0044070,0045177,0046872,0046903,0051453,0070050,0070062,2001150,2001225 -logKd/Ki=8.30, Ki=5nM Ki=10nM, Kd=290nM, IC50=5nM P00918 19827837 300 HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 3lxe A 1.9 BS02 TOR A 1 Q92 H94 H96 H119 L198 T199 H200 Q88 H90 H92 H115 L194 T195 H196 H64 H94 H96 E106 H119 T199 H60 H90 H92 E102 H115 T195 4.2.1.1,4.2.1.69 0004064,0004089,0005515,0005737,0005829,0006730,0008270,0016829,0016836,0018820,0046872,0070062 Ki=250nM -logKd/Ki=6.60, Ki=250nM Ki=250nM, IC50=250nM P00915 20505865 262 WGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 3lxe B 1.9 BS02 TOR B 1 S65 Q92 H94 H96 H119 L198 T199 H200 S61 Q88 H90 H92 H115 L194 T195 H196 H64 H94 H96 E106 H119 T199 H60 H90 H92 E102 H115 T195 4.2.1.1,4.2.1.69 0004064,0004089,0005515,0005737,0005829,0006730,0008270,0016829,0016836,0018820,0046872,0070062 Ki=250nM Ki=250nM, IC50=250nM P00915 20505865 262 WGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 5jna A 2.0 BS02 TOR A 1 N62 S65 Q92 H94 H119 L198 T199 T200 N68 S71 Q95 H97 H122 L199 T200 T201 H64 H94 H96 E106 H119 T199 H70 H97 H99 E109 H122 T200 4.2.1.1 0004089,0005515,0005791,0005793,0005794,0005802,0005886,0006730,0008270,0009897,0009986,0015701,0016020,0016323,0016324,0016829,0030658,0030667,0031526,0046872,0048471,0070062,0098552 -logKd/Ki=7.35, Kd=45nM Ki=4900nM P22748 28975383 302 AESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKS 5jna B 2.0 BS02 TOR B 1 N62 S65 Q92 H94 L198 T199 T200 N65 S68 Q92 H94 L195 T196 T197 H64 H94 H96 E106 H119 T199 H67 H94 H96 E106 H119 T196 4.2.1.1 0004089,0005515,0005791,0005793,0005794,0005802,0005886,0006730,0008270,0009897,0009986,0015701,0016020,0016323,0016324,0016829,0030658,0030667,0031526,0046872,0048471,0070062,0098552 Ki=4900nM P22748 28975383 302 HWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKS 5jna C 2.0 BS02 TOR C 1 N62 S65 Q92 H94 L198 T199 T200 N66 S69 Q93 H95 L204 T205 T206 H64 H94 H96 E106 H119 T199 H68 H95 H97 E107 H120 T205 4.2.1.1 0004089,0005515,0005791,0005793,0005794,0005802,0005886,0006730,0008270,0009897,0009986,0015701,0016020,0016323,0016324,0016829,0030658,0030667,0031526,0046872,0048471,0070062,0098552 Ki=4900nM P22748 28975383 302 SHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKS 5jna D 2.0 BS02 TOR D 1 N62 S65 Q92 H94 L198 T199 T200 N65 S68 Q92 H94 L203 T204 T205 H64 H94 H96 E106 H119 T199 H67 H94 H96 E106 H119 T204 4.2.1.1 0004089,0005515,0005791,0005793,0005794,0005802,0005886,0006730,0008270,0009897,0009986,0015701,0016020,0016323,0016324,0016829,0030658,0030667,0031526,0046872,0048471,0070062,0098552 Ki=4900nM P22748 28975383 302 HWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKS 7yg5 A 3.0 BS10 TOR A 1 E357 S602 I603 D704 N705 E282 S458 I459 D560 N561 ? 0005216,0005245,0005262,0005509,0005886,0005891,0006811,0006816,0007268,0008331,0016020,0022843,0034702,0043025,0045202,0046872,0055085,0070588,0098703 Q15878 38901222 2416 NIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERERVENRRAFMKLRRQQQIERELNGYRAWIDKAHKERLLRISIRHMVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDGTPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAFNQKHALRHHMSVWEQRTSQLRKHRACHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKMIDQGLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDTEKECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEECSLEKNERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSAPCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTDSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCEPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRLVLMNMPVAEDMTVHFTSTLMALIRTALDIKIAKGGADRQQLDSELQKETLAIWPHLSQKMLDLLVPMPKASDLTVGKIYAA