1dg5 A 2.0 BS02 TOP A 1 I5 W6 D27 F31 L50 I94 I5 W6 D27 F31 L50 I94 I5 I20 W22 D27 Q28 F31 L57 T91 T113 I5 I20 W22 D27 Q28 F31 L57 T91 T113 1.5.1.3 0004146,0005829,0006730,0016491,0046452,0046654,0046655,0050661,0070401 Ki=88uM IC50=88000nM P9WNX1 10623528 201 MVGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRRNVVLSRQADFMASGAEVVGSLEEALTSPETWVIGGGQVYALALPYATRCEVTEVDIGLPREAGDALAPVLDETWRGETGEWRFSRSGLRYRLYSYHRS 1dyr A 1.86 BS02 TOP A 1 I10 L25 E32 F36 I123 I9 L24 E31 F35 I122 L25 E32 L24 E31 1.5.1.3 0004146,0005739,0006730,0016491,0046452,0046654,0046655,0050661 ic50=20uM IC50=12000nM, Ki=280000nM P16184 7866743 407 NQQKSLTLIVALTTSYGIGRSNSLPWKLKKEISYFKRVTSFVPTFDSFESMNVVLMGRKTWESIPLQFRPLKGRINVVITRNESLDLGNGIHSAKSLDHALELLYRTYGSESSVQINRIFVIGGAQLYKAAMDHPKLDRIMATIIYKDIHCDVFFPLKFRDKEWSSVWKKEKHSDLESWVGTKVPHGKINEDGFDYEFEMWTRDL 2bfm A 2.6 BS02 TOP A 1 F113 L188 Y194 L226 H241 F101 L166 Y172 L204 H219 R17 D181 Y194 R12 D159 Y172 1.5.1.33 0004155,0005829,0006729,0016491,0031427,0047040 Q01782 16055151 1290 VPVALVTGAAKRLGRSIAEGLHAEGYAVCLHYHRSAAEANALSATLNARRPNSAITVQADLSNVATAPAPVTLFTRCAELVAACYTHWGRCDVLVNNASSFYPTPLLRGDREAMETATADLFGSNAIAPYFLIKAFAHRVAGTPAKHRGTNYSIINMVDAMTNQPLLGYTIYTMAKGALEGLTRSAALELAPLQIRVNGVGPGLSVLVDDMPPAVWEGHRSKVPLYQRDSSAAEVSDVVIFLCSSKAKYITGTCVKVDGGYSLTRA 2bfm B 2.6 BS02 TOP B 1 F113 L188 Y194 L226 H241 F102 L166 Y172 L204 H219 R17 D181 Y194 R12 D159 Y172 1.5.1.33 0004155,0005829,0006729,0016491,0031427,0047040 Q01782 16055151 1290 VPVALVTGAAKRLGRSIAEGLHAEGYAVCLHYHRSAAEANALSATLNARRPNSAITVQADLSNVATAPVAPVTLFTRCAELVAACYTHWGRCDVLVNNASSFYPTPLLRNREAMETATADLFGSNAIAPYFLIKAFAHRVAGTPAKHRGTNYSIINMVDAMTNQPLLGYTIYTMAKGALEGLTRSAALELAPLQIRVNGVGPGLSVLVDDMPPAVWEGHRSKVPLYQRDSSAAEVSDVVIFLCSSKAKYITGTCVKVDGGYSLTRA 2w3a A 1.5 BS02 TOP A 1 I7 V8 E30 F31 F34 I60 I7 V8 E30 F31 F34 I60 L22 E30 L22 E30 1.5.1.3 0000900,0003723,0003729,0004146,0005542,0005737,0005739,0005829,0006729,0006730,0008144,0016491,0017148,0031103,0031427,0046452,0046653,0046654,0046655,0050661,0051000,0070402,1990825,2000121 IC50=680000nM, Ki=19070nM P00374 1190 VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND 2w3a B 1.5 BS02 TOP B 1 I7 V8 A9 E30 F31 F34 I7 V8 A9 E30 F31 F34 L22 E30 L22 E30 1.5.1.3 0000900,0003723,0003729,0004146,0005542,0005737,0005739,0005829,0006729,0006730,0008144,0016491,0017148,0031103,0031427,0046452,0046653,0046654,0046655,0050661,0051000,0070402,1990825,2000121 IC50=680000nM, Ki=19070nM P00374 1189 VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND 2w3v A 1.89 BS02 TOP A 1 V9 W10 I24 D31 F35 L54 I102 V7 W8 I22 D29 F33 L52 I100 V9 I24 W26 D31 L32 F35 L61 P99 T121 V7 I22 W24 D29 L30 F33 L59 P97 T119 1.5.1.3 0000166,0004146,0005829,0006730,0016491,0046452,0046654,0046655,0050661 IC50=190nM O30463 1169 RAEVGLVWAQSTSGVIGRGGDIPWSVPEDLTRFKEVTMGHTVIMGRRTWESLPAKVRPLPGRRNVVVSRRPDFVAEGARVAGSLEAALAYAGSDPAPWVIGGAQIYLLALPHATRCEVTEIEIDLRRDDDDALAPALDDSWVGETGEWLASRSGLRYRFHSYRRD 2w9g A 1.95 BS01 TOP A 1 L5 V6 A7 D27 V31 I50 F92 R156 K157 L5 V6 A7 D27 V31 I50 F92 R156 K157 L5 L20 W22 D27 L28 V31 L54 V89 T111 L5 L20 W22 D27 L28 V31 L54 V89 T111 1.5.1.3 0004146,0005829,0006730,0016491,0046452,0046654,0046655,0050661 Kd=0.97nM Ki=3.4nM, IC50=14.4nM P0A017 19280600 1159 TLSILVAHDLQRVIGFENQLPWHLPNDLKHVKKLSTGHTLVMGRKTFESIGKPLPNRRNVVLTSDTSFNVEGVDVIHSIEDIYQLPGHVFIFGGQTLFEEMIDKVDDMYITVIEGKFRGDTFFPPYTFEDWEVASSVEGKLDEKNTIPHTFLHLIRK 2w9h A 1.48 BS01 TOP A 1 L5 V6 A7 L20 D27 V31 S49 F92 L5 V6 A7 L20 D27 V31 S49 F92 L5 L20 W22 D27 L28 V31 L54 V89 T111 L5 L20 W22 D27 L28 V31 L54 V89 T111 1.5.1.3 0004146,0005829,0006730,0016491,0046452,0046654,0046655,0050661 Kd=430nM -logKd/Ki=6.37, Kd=430nM Ki=3.4nM, IC50=14.4nM P0A017 19280600 1160 TLSILVAHDLQRVIGFENQLPWHLPNDLKHVKKLSTGHTLVMGRKTFESIGKPLPNRRNVVLTSDTSFNVEGVDVIHSIEDIYQLPGHVFIFGGQTLFEEMIDKVDDMYITVIEGKFRGDTFFPPYTFEDWEVASSVEGKLDEKNTIPHTFLHLIRK 2w9s A 1.8 BS02 TOP A 1 I5 V6 A7 L20 D27 I31 I50 F92 I5 V6 A7 L20 D27 I31 I50 F92 I5 L20 W22 D27 L28 I31 L54 V89 T111 I5 L20 W22 D27 L28 I31 L54 V89 T111 1.5.1.3 0004146,0005829,0006730,0016491,0031427,0046452,0046654,0046655,0046677,0050661 Kd=730nM IC50=1.51e+4nM P13955 19280600 1160 TLSIIVAHDKQRVIGYQNQLPWHLPNDLKHIKQLTTGNTLVMARKTFESIGKPLPNRRNVVLTNQASFHHEGVDVINSLDEIKELSGHVFIFGGQTLYEAMIDQVDDMYITVIDGKFQGDTFFPPYTFEDWEVESSVEGQLDEKNTIPHTFLHLVRR 2w9s B 1.8 BS02 TOP B 1 I5 V6 A7 L20 D27 I31 I50 F92 I5 V6 A7 L20 D27 I31 I50 F92 I5 L20 W22 D27 L28 I31 L54 V89 T111 I5 L20 W22 D27 L28 I31 L54 V89 T111 1.5.1.3 0004146,0005829,0006730,0016491,0031427,0046452,0046654,0046655,0046677,0050661 Kd=730nM IC50=1.51e+4nM P13955 19280600 1160 TLSIIVAHDKQRVIGYQNQLPWHLPNDLKHIKQLTTGNTLVMARKTFESIGKPLPNRRNVVLTNQASFHHEGVDVINSLDEIKELSGHVFIFGGQTLYEAMIDQVDDMYITVIDGKFQGDTFFPPYTFEDWEVESSVEGQLDEKNTIPHTFLHLVRR 2w9s C 1.8 BS02 TOP C 1 I5 V6 A7 L20 D27 I31 I50 F92 I5 V6 A7 L20 D27 I31 I50 F92 I5 L20 W22 D27 L28 I31 L54 V89 T111 I5 L20 W22 D27 L28 I31 L54 V89 T111 1.5.1.3 0004146,0005829,0006730,0016491,0031427,0046452,0046654,0046655,0046677,0050661 Kd=730nM IC50=1.51e+4nM P13955 19280600 1160 TLSIIVAHDKQRVIGYQNQLPWHLPNDLKHIKQLTTGNTLVMARKTFESIGKPLPNRRNVVLTNQASFHHEGVDVINSLDEIKELSGHVFIFGGQTLYEAMIDQVDDMYITVIDGKFQGDTFFPPYTFEDWEVESSVEGQLDEKNTIPHTFLHLVRR 2w9s D 1.8 BS01 TOP D 1 I5 V6 A7 L20 D27 I31 F92 I5 V6 A7 L20 D27 I31 F92 I5 L20 W22 D27 L28 I31 L54 V89 T111 I5 L20 W22 D27 L28 I31 L54 V89 T111 1.5.1.3 0004146,0005829,0006730,0016491,0031427,0046452,0046654,0046655,0046677,0050661 Kd=730nM IC50=1.51e+4nM P13955 19280600 1158 TLSIIVAHDKQRVIGYQNQLPWHLPNDLKHIKQLTTGNTLVMARKTFESIGKPLPNRRNVVLTNQASFHHEGVDVINSLDEIKELSGHVFIFGGQTLYEAMIDQVDDMYITVIDGKFQGDTFFPPYTFEDWEVESSVEGQLDEKNTIPHTFLHLVRR 2w9s E 1.8 BS01 TOP E 1 I5 V6 A7 L20 D27 I31 F92 I5 V6 A7 L20 D27 I31 F92 I5 L20 W22 D27 L28 I31 L54 V89 T111 I5 L20 W22 D27 L28 I31 L54 V89 T111 1.5.1.3 0004146,0005829,0006730,0016491,0031427,0046452,0046654,0046655,0046677,0050661 Kd=730nM IC50=1.51e+4nM P13955 19280600 1160 TLSIIVAHDKQRVIGYQNQLPWHLPNDLKHIKQLTTGNTLVMARKTFESIGKPLPNRRNVVLTNQASFHHEGVDVINSLDEIKELSGHVFIFGGQTLYEAMIDQVDDMYITVIDGKFQGDTFFPPYTFEDWEVESSVEGQLDEKNTIPHTFLHLVRR 2w9s F 1.8 BS01 TOP F 1 I5 V6 A7 L20 D27 I31 F92 I5 V6 A7 L20 D27 I31 F92 I5 L20 W22 D27 L28 I31 L54 V89 T111 I5 L20 W22 D27 L28 I31 L54 V89 T111 1.5.1.3 0004146,0005829,0006730,0016491,0031427,0046452,0046654,0046655,0046677,0050661 Kd=730nM IC50=1.51e+4nM P13955 19280600 1159 TLSIIVAHDKQRVIGYQNQLPWHLPNDLKHIKQLTTGNTLVMARKTFESIGKPLPNRRNVVLTNQASFHHEGVDVINSLDEIKELSGHVFIFGGQTLYEAMIDQVDDMYITVIDGKFQGDTFFPPYTFEDWEVESSVEGQLDEKNTIPHTFLHLVRR 3fl9 A 2.4 BS02 TOP A 1 M6 V7 A8 V32 I51 L55 F96 M6 V7 A8 V32 I51 L55 F96 M6 L21 W23 E28 L29 V32 L55 I93 T115 M6 L21 W23 E28 L29 V32 L55 I93 T115 1.5.1.3 0000166,0004146,0005829,0006730,0016491,0046452,0046654,0046655,0046872,0050661 ic50=77.2mM -logKd/Ki=1.11, IC50=77.2mM Ki=24100nM, IC50=71000nM Q81R22 19364848 200 MIVSFMVAMDENRVIGKDNNLPWRLPSELQYVKKTTMGHPLIMGRKNYEAIGRPLPGRRNIIVTRNEGYHVEGCEVAHSVEEVFELCKNEEEIFIFGGAQIYDLFLPYVDKLYITKIHHAFEGDTFFPEMDNWKEVFVEKGLTDEKNPYTYYYHVYEKQQLVPR 3fl9 B 2.4 BS02 TOP B 1 M6 V7 A8 L21 E28 V32 A50 I51 F96 M6 V7 A8 L20 E27 V31 A49 I50 F95 M6 L21 W23 E28 L29 V32 L55 I93 T115 M6 L20 W22 E27 L28 V31 L54 I92 T114 1.5.1.3 0000166,0004146,0005829,0006730,0016491,0046452,0046654,0046655,0046872,0050661 ic50=77.2mM Ki=24100nM, IC50=71000nM Q81R22 19364848 200 MIVSFMVAMDENRVIGKDNLPWRLPSELQYVKKTTMGHPLIMGRKNYEAIGRPLPGRRNIIVTRNEGYHVEGCEVAHSVEEVFELCKNEEEIFIFGGAQIYDLFLPYVDKLYITKIHHAFEGDTFFPEMDWKEVFVEKGLTDEKNPYTYYYHVYEKQQ 3fl9 C 2.4 BS02 TOP C 1 M6 V7 A8 E28 L29 V32 I51 F96 M6 V7 A8 E28 L29 V32 I51 F96 M6 L21 W23 E28 L29 V32 L55 I93 T115 M6 L21 W23 E28 L29 V32 L55 I93 T115 1.5.1.3 0000166,0004146,0005829,0006730,0016491,0046452,0046654,0046655,0046872,0050661 ic50=77.2mM Ki=24100nM, IC50=71000nM Q81R22 19364848 200 MIVSFMVAMDENRVIGKDNNLPWRLPSELQYVKKTTMGHPLIMGRKNYEAIGRPLPGRRNIIVTRNEGYHVEGCEVAHSVEEVFELCKNEEEIFIFGGAQIYDLFLPYVDKLYITKIHHAFEGDTFFPEMDTNWKEVFVEKGLTDEKNPYTYYYHVYEKQQLVPR 3fl9 D 2.4 BS02 TOP D 1 M6 V7 A8 E28 V32 I51 L55 F96 M6 V7 A8 E28 V32 I51 L55 F96 M6 L21 W23 E28 L29 V32 L55 I93 T115 M6 L21 W23 E28 L29 V32 L55 I93 T115 1.5.1.3 0000166,0004146,0005829,0006730,0016491,0046452,0046654,0046655,0046872,0050661 ic50=77.2mM Ki=24100nM, IC50=71000nM Q81R22 19364848 200 MIVSFMVAMDENRVIGKDNNLPWRLPSELQYVKKTTMGHPLIMGRKNYEAIGRPLPGRRNIIVTRNEGYHVEGCEVAHSVEEVFELCKNEEEIFIFGGAQIYDLFLPYVDKLYITKIHHAFEGDTFFPEMDMNWKEVFVEKGLTDEKNPYTYYYHVYEKQQLVPR 3fl9 E 2.4 BS01 TOP E 1 M6 V7 A8 L21 E28 L29 V32 I51 L55 F96 M6 V7 A8 L21 E28 L29 V32 I51 L55 F96 M6 L21 W23 E28 L29 V32 L55 I93 T115 M6 L21 W23 E28 L29 V32 L55 I93 T115 1.5.1.3 0000166,0004146,0005829,0006730,0016491,0046452,0046654,0046655,0046872,0050661 ic50=77.2mM Ki=24100nM, IC50=71000nM Q81R22 19364848 200 MIVSFMVAMDENRVIGKDNNLPWRLPSELQYVKKTTMGHPLIMGRKNYEAIGRPLPGRRNIIVTRNEGYHVEGCEVAHSVEEVFELCKNEEEIFIFGGAQIYDLFLPYVDKLYITKIHHAFEGDTFFPEMDMWKEVFVEKGLTDEKNPYTYYYHVYEKQQLVPR 3fl9 F 2.4 BS02 TOP F 1 M6 V7 A8 L21 E28 V32 I51 F96 M6 V7 A8 L21 E28 V32 I51 F96 M6 L21 W23 E28 L29 V32 L55 I93 T115 M6 L21 W23 E28 L29 V32 L55 I93 T115 1.5.1.3 0000166,0004146,0005829,0006730,0016491,0046452,0046654,0046655,0046872,0050661 ic50=77.2mM Ki=24100nM, IC50=71000nM Q81R22 19364848 200 MIVSFMVAMDENRVIGKDNNLPWRLPSELQYVKKTTMGHPLIMGRKNYEAIGRPLPGRRNIIVTRNEGYHVEGCEVAHSVEEVFELCKNEEEIFIFGGAQIYDLFLPYVDKLYITKIHHAFEGDTFFPEMDMTWKEVFVEKGLTDEKNPYTYYYHVYEKQQLVPR 3fl9 G 2.4 BS01 TOP G 1 M6 V7 A8 L21 E28 L29 V32 I51 L55 F96 M6 V7 A8 L21 E28 L29 V32 I51 L55 F96 M6 L21 W23 E28 L29 V32 L55 I93 T115 M6 L21 W23 E28 L29 V32 L55 I93 T115 1.5.1.3 0000166,0004146,0005829,0006730,0016491,0046452,0046654,0046655,0046872,0050661 ic50=77.2mM Ki=24100nM, IC50=71000nM Q81R22 19364848 200 MIVSFMVAMDENRVIGKDNNLPWRLPSELQYVKKTTMGHPLIMGRKNYEAIGRPLPGRRNIIVTRNEGYHVEGCEVAHSVEEVFELCKNEEEIFIFGGAQIYDLFLPYVDKLYITKIHHAFEGDTFFPEMDNWKEVFVEKGLTDEKNPYTYYYHVYEKQQLVPR 3fl9 H 2.4 BS02 TOP H 1 M6 V7 A8 E28 L29 V32 I51 L55 F96 M6 V7 A8 E28 L29 V32 I51 L55 F96 M6 L21 W23 E28 L29 V32 L55 I93 T115 M6 L21 W23 E28 L29 V32 L55 I93 T115 1.5.1.3 0000166,0004146,0005829,0006730,0016491,0046452,0046654,0046655,0046872,0050661 ic50=77.2mM Ki=24100nM, IC50=71000nM Q81R22 19364848 200 MIVSFMVAMDENRVIGKDNNLPWRLPSELQYVKKTTMGHPLIMGRKNYEAIGRPLPGRRNIIVTRNEGYHVEGCEVAHSVEEVFELCKNEEEIFIFGGAQIYDLFLPYVDKLYITKIHHAFEGDTFFPEMDNWKEVFVEKGLTDEKNPYTYYYHVYEKQQLVPR 3frb X 2.0 BS02 TOP X 1 L5 V6 A7 D27 L28 V31 I50 F92 L5 V6 A7 D27 L28 V31 I50 F92 L5 L5 1.5.1.3 0004146,0005829,0006730,0016491,0046452,0046654,0046655,0050661 Ka=5800000M^-1 Ki=3.4nM, IC50=14.4nM P0A017 19211577 300 TLSILVAHDLQRVIGFENQLPWHLPNDLKHVKKLSTGHTLVMGRKTFESIGKPLPNRRNVVLTSDTSFNVEGVDVIHSIEDIYQLPGHVFIFGGQTLYEEMIDKVDDMYITVIEGKFRGDTFFPPYTFEDWEVASSVEGKLDEKNTIPHTFLHLIRK 3fre X 2.2 BS02 TOP X 1 L5 V6 A7 D27 L28 V31 F92 L5 V6 A7 D27 L28 V31 F92 L5 L5 1.5.1.3 0004146,0005829,0006730,0016491,0046452,0046654,0046655,0050661 Ki=0.0006uM Ki=3.4nM, IC50=14.4nM P0A017 19211577 300 TLSILVAHDLQRVIGFENQLPWHLPNDLKHVKKLSTGHTLVMGRKTFESIGKPLPNRRNVVLTSDTSFNVEGVDVIHSIEDIYQLPGHVFIFGGQTLFEEMIDKVDDMYITVIEGKFRGDTFFPPYTFEDWEVASSVEGKLDEKNTIPHTFLHLIRK 3jw3 A 2.57 BS02 TOP A 1 M6 V7 A8 E28 V32 I51 I96 M9 V10 A11 E31 V35 I54 I99 M6 L21 W23 E28 L29 V32 L55 I93 T115 M9 L24 W26 E31 L32 V35 L58 I96 T118 1.5.1.3 0000166,0004146,0005829,0006730,0016491,0046452,0046654,0046655,0046872,0050661 Ki=24100nM, IC50=71000nM Q81R22 208 HHHMRVSFMVAMDENRVIGKDNNLPWRLPSELQYVKKTTMGHPLIMGRKNYEAIGRPLPGRRNIIVTRNEGYHVEGCEVAHSVEEVFELCKNEEEIFIIGGAQIYDLFLPYVDKLYITKIHHAFEGDTFFPEMDMTNWKEVFVEKGLTDEKNPYTYYYHVYEKQQ 3jw3 B 2.57 BS02 TOP B 1 M6 V7 A8 E28 V32 I51 I96 M9 V10 A11 E31 V35 I54 I99 M6 L21 W23 E28 L29 V32 L55 I93 T115 M9 L24 W26 E31 L32 V35 L58 I96 T118 1.5.1.3 0000166,0004146,0005829,0006730,0016491,0046452,0046654,0046655,0046872,0050661 Ki=24100nM, IC50=71000nM Q81R22 208 HHHMRVSFMVAMDENRVIGKDNNLPWRLPSELQYVKKTTMGHPLIMGRKNYEAIGRPLPGRRNIIVTRNEGYHVEGCEVAHSVEEVFELCKNEEEIFIIGGAQIYDLFLPYVDKLYITKIHHAFEGDTFFPEMDMTNWKEVFVEKGLTDEKNPYTYYYHVYEKQQ 3jw5 A 2.89 BS02 TOP A 1 M6 V7 A8 L21 E28 L29 V32 I51 F96 M9 V10 A11 L24 E31 L32 V35 I54 F99 M6 L21 W23 E28 L29 V32 L55 I93 T115 M9 L24 W26 E31 L32 V35 L58 I96 T118 1.5.1.3 0000166,0004146,0005829,0006730,0016491,0046452,0046654,0046655,0046872,0050661 Ki=24100nM, IC50=71000nM Q81R22 208 HHHMRVSFMVAMDENRVIGKDNNLPWRLPSELQYVKKTTMGHPLIMGRKNYEAIGRPLPGRRNIIVTRNEGYHVEGCEVAHSVEEVFELCKNEEEIFIFGGAQIFDLFLPYVDKLYITKIHHAFEGDTFFPEMDMTNWKEVFVEKGLTDEKNPYTYYYHVYEKQQ 3jw5 B 2.89 BS02 TOP B 1 V7 A8 L21 E28 V32 A50 I51 L55 F96 V10 A11 L24 E31 V35 A53 I54 L58 F99 M6 L21 W23 E28 L29 V32 L55 I93 T115 M9 L24 W26 E31 L32 V35 L58 I96 T118 1.5.1.3 0000166,0004146,0005829,0006730,0016491,0046452,0046654,0046655,0046872,0050661 Ki=24100nM, IC50=71000nM Q81R22 208 HHHMRVSFMVAMDENRVIGKDNNLPWRLPSELQYVKKTTMGHPLIMGRKNYEAIGRPLPGRRNIIVTRNEGYHVEGCEVAHSVEEVFELCKNEEEIFIFGGAQIFDLFLPYVDKLYITKIHHAFEGDTFFPEMDMTNWKEVFVEKGLTDEKNPYTYYYHVYEKQQ 3n0h A 1.92 BS01 TOP A 1 V8 A9 E30 F31 F34 I60 L67 V8 A9 E30 F31 F34 I60 L67 L22 E30 L22 E30 1.5.1.3 0000900,0003723,0003729,0004146,0005542,0005737,0005739,0005829,0006729,0006730,0008144,0016491,0017148,0031103,0031427,0046452,0046653,0046654,0046655,0050661,0051000,0070402,1990825,2000121 Ki=617nM -logKd/Ki=6.21, Ki=617nM IC50=680000nM, Ki=19070nM P00374 21684339 187 VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFSRMTTTSSVEGKQNLVIMGKKTWFSIPEKFRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND 3n0h A 1.92 BS02 TOP A 2 S59 P61 F64 S59 P61 F64 L22 E30 L22 E30 1.5.1.3 0000900,0003723,0003729,0004146,0005542,0005737,0005739,0005829,0006729,0006730,0008144,0016491,0017148,0031103,0031427,0046452,0046653,0046654,0046655,0050661,0051000,0070402,1990825,2000121 Ki=617nM -logKd/Ki=6.21, Ki=617nM IC50=680000nM, Ki=19070nM P00374 21684339 191 VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFSRMTTTSSVEGKQNLVIMGKKTWFSIPEKFRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND 3s3v A 1.53 BS01 TOP A 1 V8 E30 F31 F34 K35 I60 L67 V8 E30 F31 F34 K35 I60 L67 L22 E30 L22 E30 1.5.1.3 0000900,0003723,0003729,0004146,0005542,0005737,0005739,0005829,0006729,0006730,0008144,0016491,0017148,0031103,0031427,0046452,0046653,0046654,0046655,0050661,0051000,0070402,1990825,2000121 Ki=593nM -logKd/Ki=6.23, Ki=593nM IC50=680000nM, Ki=19070nM P00374 21684339 187 VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFKRMTTTSSVEGKQNLVIMGKKTWFSIPEKFRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND 3s3v A 1.53 BS02 TOP A 2 S59 P61 F64 S59 P61 F64 L22 E30 L22 E30 1.5.1.3 0000900,0003723,0003729,0004146,0005542,0005737,0005739,0005829,0006729,0006730,0008144,0016491,0017148,0031103,0031427,0046452,0046653,0046654,0046655,0050661,0051000,0070402,1990825,2000121 Ki=593nM -logKd/Ki=6.23, Ki=593nM IC50=680000nM, Ki=19070nM P00374 21684339 193 VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFKRMTTTSSVEGKQNLVIMGKKTWFSIPEKFRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND 3tq8 A 1.9 BS02 TOP A 1 I6 A7 A8 L21 D28 F32 I51 I96 I6 A7 A8 L21 D28 F32 I51 I96 I6 L21 W23 D28 L29 F32 L55 V93 T115 I6 L21 W23 D28 L29 F32 L55 V93 T115 1.5.1.3 0000166,0004146,0005829,0006730,0016491,0046452,0046654,0046655,0050661 Q83AB2 26033498 2001 MIITLIAAMDKNRLIGRNNELPWHLPADLAHFKSITLGKPIVMGRRTFDSIGKPLPHRRNIVITQQKNLIIEGCDIFYSLDDALSALTKEPEVIIIGGARIFKEALPKADKMILTIINHSFEGDVYFPEWNDKEWKITSQIKHERDNPYPFQFLELRRLENLYFQGHHHHH 4g8z X 1.75 BS01 TOP X 1 I10 V11 A12 L25 E32 F36 S64 I123 I8 V9 A10 L23 E30 F34 S62 I121 1.5.1.3 0004146,0005739,0006730,0016491,0046452,0046654,0046655,0050661 Ki=227nM IC50=12000nM, Ki=280000nM P16184 23545530 301 QQKSLTLIVALTTSYGIGRSNSLPWKLKKEISYFSRVTSFVPTFDSFESMNVVLMGRKTWESIPLQNRPLKGRINVVITRNAAAAAAAAIHSAKSLDHALELLYRTYGSESSVQINRIFVIGGAQLYKAAMDHPKLDRIMATIIYKDIHCDVFFPLKFRDKEWSSVWKKEKHSDLESWVGTKVPHGKINEDGFDYEFEMWTRDL 4km2 A 1.4 BS02 TOP A 1 I5 W6 D27 F31 I94 I5 W6 D27 F31 I94 I5 I20 W22 D27 Q28 F31 L57 T91 T113 I5 I20 W22 D27 Q28 F31 L57 T91 T113 1.5.1.3 0004146,0005829,0006730,0016491,0046452,0046654,0046655,0050661,0070401 Kd=1.43uM -logKd/Ki=5.84, Kd=1.43uM IC50=88000nM P9WNX1 24210757 202 MVGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRRNVVLSRQADFMASGAEVVGSLEEALTSPETWVIGGGQVYALALPYATRCEVTEVDIGLPREAGDALAPVLDETWRGETGEWRFSRSGLRYRLYSYHRS 4km2 B 1.4 BS02 TOP B 1 I5 W6 D27 F31 L50 L57 I94 I5 W6 D27 F31 L50 L57 I94 I5 I20 W22 D27 Q28 F31 L57 T91 T113 I5 I20 W22 D27 Q28 F31 L57 T91 T113 1.5.1.3 0004146,0005829,0006730,0016491,0046452,0046654,0046655,0050661,0070401 Kd=1.43uM IC50=88000nM P9WNX1 24210757 202 MVGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRRNVVLSRQADFMASGAEVVGSLEEALTSPETWVIGGGQVYALALPYATRCEVTEVDIGLPREAGDALAPVLDETWRGETGEWRFSRSGLRYRLYSYHRS 4xt7 A 2.3 BS02 TOP A 1 N44 F45 I46 S59 G60 D67 R68 F71 E91 T214 N32 F33 I34 S47 G48 D55 R56 F59 E79 T202 ? 0000166,0005829,0008703,0009231,0016491 ic50=93.5uM P71968 26848874 302 PLRLLSSVHYLTDGELPQLYDYPDDGTWLRANFISSLDGGATVDGTSGAMAGPGDRFVFNLLRELADVIVVGVGTVRIEGYSGVRMGVVQRQHRQARGQSEVPQLAIVTRSGRLDRDMAVFTRTEMAPLVLTTTAVADDTRQRLAGLAEVIACSGDDPGTVDEAVLVSQLAARGLRRILTEGGPTLLGTFVERDVLDELCLTIAPYVVGGLARRIVTGPGQVLTRMRCAHVLTDDSGYLYTRYVKT 6rul A 2.2 BS01 TOP A 1 D102 F106 I169 I244 A245 M259 D106 F110 I173 I246 A247 M261 N95 G97 D102 L103 F106 L129 I166 T188 N99 G101 D106 L107 F110 L133 I170 T192 1.5.1.3 0004146,0005515,0005542,0005829,0006730,0009257,0009410,0016491,0031427,0046452,0046654,0046655,0046656,0046677,0050661,0051870,0051871,0070401,0070402 IC50=10nM, Ki=3.0nM P0ABQ4 32066961 301 QVQLVESGGALVQPGGSLRLSCAASGFPVNRYSMRWYRQAPGKEREWVAGMSSAGDRSSYEDSVKGRFTISRDDARNTVYLQMNSLKPEDTAVYYCNVNVGFLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERRGGGMISLIAALAVDRVIGMENAMPWNEYWGQGTQVTVS 6rum A 1.6 BS01 TOP A 1 D101 F105 I124 I168 I243 A244 M258 D105 F109 I128 I172 I245 A246 M260 G97 D101 L102 F105 L128 I165 T187 G101 D105 L106 F109 L132 I169 T191 1.5.1.3 0004146,0046654 IC50=10nM, Ki=3.0nM P0ABQ4 32066961 301 QVQLVESGGALVQPGGSLRLSCAASGFPVNRYSMRWYRQAPGKEREWVAGMSSAGDRSSYEDSVKGRFTISRDDARNTVYLQMNSLKPEDTAVYYCNVNVGLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERRGGGMISLIAALAVDRVIGMENAMPWNFEYWGQGTQVTVS 6xg4 A 2.1 BS02 TOP A 1 I5 A6 M20 D27 F31 S49 I50 I94 I5 A6 M20 D27 F31 S49 I50 I94 I5 M20 W22 D27 R28 F31 L54 I91 T113 I5 M20 W22 D27 R28 F31 L54 I91 T113 1.5.1.3 0004146,0005515,0005542,0005829,0006730,0009257,0009410,0016491,0031427,0046452,0046654,0046655,0046656,0046677,0050661,0051870,0051871,0070401,0070402 IC50=10nM, Ki=3.0nM P0ABQ4 34011959 303 MISLIAALAVDRVIGMENAMPWNLPADRAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 6xg5 A 1.9 BS02 TOP A 1 I5 A6 M20 D27 F31 S49 I50 I94 I5 A6 M20 D27 F31 S49 I50 I94 I5 M20 W22 D27 L28 F31 L54 I91 T113 I5 M20 W22 D27 L28 F31 L54 I91 T113 1.5.1.3 0004146,0005515,0005542,0005829,0006730,0009257,0009410,0016491,0031427,0046452,0046654,0046655,0046656,0046677,0050661,0051870,0051871,0070401,0070402 IC50=10nM, Ki=3.0nM P0ABQ4 34011959 303 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 7f3z A 2.6 BS03 TOP A 1 I14 C15 L46 D54 M55 F58 P113 I164 I14 C15 L46 D54 M55 F58 P104 I155 1.5.1.3,2.1.1.45 0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 Ki=10.3nM, IC50=10nM P13922 34614393 703 MMEQVCDVFDIYAICACCKVESKNEGKKNEVFNNYTFRGLGNKGVLPWKCNSLDMKYFRAVTTYVNESKYEKLKYKRCKYLNKETVKKLQNVVVMGRTNWESIPKKFKPLSNRINVILSRTLKKEDFDEDVYIINKVEDLIVLLGKLNYYKCFIIGGSVVYQEFLEKKLIKKIYFTRINSTYECDVFFPEINENEYQIISVSDVYTSNNTTLDFIIYKKTNNDDEEEDDFVYFNFNKEKEEKNKNSIHPNDFQIYNSLKYKYHPEYQYLNIIYDIMMNGNKQSDRTGVGVLSKFGYIMKFDLSQYFPLLTTKKLFLRGIIEELLWFIRGETNGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLGPIYGFQWRHFGAEYTNMYDNYENKGVDQLKNIINLIKNDPTSRRILLCAWNVKDLDQMALPPCHILCQFYVFDGKLSCIMYQRSCDLGLGVPFNIASYSIFTHMIAQVCNLQPAQFIHVLGNAHVYNNHIDSLKIQLNRIPYPFPTLKLNPDIKNIEDFTISDFTIQNYVHHEKISMDMAA 7f3z B 2.6 BS04 TOP B 1 I14 C15 A16 L46 D54 M55 F58 P113 I164 I14 C15 A16 L46 D54 M55 F58 P104 I155 1.5.1.3,2.1.1.45 0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 Ki=10.3nM, IC50=10nM P13922 34614393 703 MMEQVCDVFDIYAICACCKVESKNEGKKNEVFNNYTFRGLGNKGVLPWKCNSLDMKYFRAVTTYVNESKYEKLKYKRCKYLNKETSKKLQNVVVMGRTNWESIPKKFKPLSNRINVILSRTLKKEDFDEDVYIINKVEDLIVLLGKLNYYKCFIIGGSVVYQEFLEKKLIKKIYFTRINSTYECDVFFPEINENEYQIISVSDVYTSNNTTLDFIIYKKTNNDDEEEDDFVYFNFNKEKEEKNKNSIHPNDFQIYNSLKYKYHPEYQYLNIIYDIMMNGNKQSDRTGVGVLSKFGYIMKFDLSQYFPLLTTKKLFLRGIIEELLWFIRGETNGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLGPIYGFQWRHFGAEYTNMYDNYENKGVDQLKNIINLIKNDPTSRRILLCAWNVKDLDQMALPPCHILCQFYVFDGKLSCIMYQRSCDLGLGVPFNIASYSIFTHMIAQVCNLQPAQFIHVLGNAHVYNNHIDSLKIQLNRIPYPFPTLKLNPDIKNIEDFTISDFTIQNYVHHEKISMDMAA 7myl A 2.15 BS01 TOP A 1 M6 V7 N17 F32 S50 M51 S97 M6 V7 N17 F32 S50 M51 S97 1.5.1.3 0000166,0004146,0016491,0046452,0046654,0046655,0050661 A4GRC7 35562546 201 MKLSLMVAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMGALPNRKYAVVTRSSFTSDNENVLIFPSIKDALTNLKKITDHVIVSGGGEIYKSLIDQVDTLHISTIDIEPEGDVYFPEIPSNFRPVFTQDFASNINYSYQIWQKG 7myl B 2.15 BS01 TOP B 1 M6 V7 A8 N17 F32 S50 M51 S97 M6 V7 A8 N17 F32 S50 M51 S97 1.5.1.3 0000166,0004146,0016491,0046452,0046654,0046655,0050661 A4GRC7 35562546 201 MKLSLMVAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMGALPNRKYAVVTRSSFTSDNENVLIFPSIKDALTNLKKITDHVIVSGGGEIYKSLIDQVDTLHISTIDIEPEGDVYFPEIPSNFRPVFTQDFASNINYSYQIWQKGL 7myl C 2.15 BS01 TOP C 1 M6 V7 A8 N17 P19 F32 S50 M51 S97 M6 V7 A8 N17 P19 F32 S50 M51 S92 1.5.1.3 0000166,0004146,0016491,0046452,0046654,0046655,0050661 A4GRC7 35562546 201 MKLSLMVAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMGALPNRKYAVVTRSSFNVLIFPSIKDALTNLKKITDHVIVSGGGEIYKSLIDQVDTLHISTIDIEPEGDVYFPEIPSNFRPVFTQDFASNINYSYQIWQKGLEHH 7myl D 2.15 BS01 TOP D 1 M6 V7 A8 N17 G18 F32 S50 M51 S97 M6 V7 A8 N17 G18 F32 S50 M51 S97 1.5.1.3 0000166,0004146,0016491,0046452,0046654,0046655,0050661 A4GRC7 35562546 201 MKLSLMVAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMGALPNRKYAVVTRSSFTSDNENVLIFPSIKDALTNLKKITDHVIVSGGGEIYKSLIDQVDTLHISTIDIEPEGDVYFPEIPSNFRPVFTQDFASNINYSYQIWQK 7myl E 2.15 BS01 TOP E 1 M6 V7 A8 N17 F32 S50 M51 S97 M6 V7 A8 N17 F32 S50 M51 S97 1.5.1.3 0000166,0004146,0016491,0046452,0046654,0046655,0050661 A4GRC7 35562546 201 MKLSLMVAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMGALPNRKYAVVTRSSFTSDNENVLIFPSIKDALTNLKKITDHVIVSGGGEIYKSLIDQVDTLHISTIDIEPEGDVYFPEIPSNFRPVFTQDFASNINYSYQIWQK 7myl F 2.15 BS01 TOP F 1 M6 V7 A8 N17 G18 F32 S50 M51 S97 M6 V7 A8 N17 G18 F32 S50 M51 S97 1.5.1.3 0000166,0004146,0016491,0046452,0046654,0046655,0050661 A4GRC7 35562546 201 MKLSLMVAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMGALPNRKYAVVTRSSFTSDNENVLIFPSIKDALTNLKKITDHVIVSGGGEIYKSLIDQVDTLHISTIDIEPEGDVYFPEIPSNFRPVFTQDFASNINYSYQIWQKG 7mym A 3.04 BS03 TOP A 1 I5 A6 M20 D27 L28 F31 I50 I94 I5 A6 M20 D27 L28 F31 I50 I94 1.5.1.3 0004146,0005515,0005542,0005829,0006730,0009257,0009410,0016491,0031427,0046452,0046654,0046655,0046656,0046677,0050661,0051870,0051871,0070401,0070402 P0ABQ4 35562546 203 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 7mym B 3.04 BS02 TOP B 1 I5 A6 M20 D27 F31 I50 I94 I5 A6 M20 D27 F31 I50 I94 1.5.1.3 0004146,0005515,0005542,0005829,0006730,0009257,0009410,0016491,0031427,0046452,0046654,0046655,0046656,0046677,0050661,0051870,0051871,0070401,0070402 P0ABQ4 35562546 202 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 7mym C 3.04 BS03 TOP C 1 I5 A6 D27 F31 S49 I50 I94 I5 A6 D27 F31 S49 I50 I94 1.5.1.3 0004146,0005515,0005542,0005829,0006730,0009257,0009410,0016491,0031427,0046452,0046654,0046655,0046656,0046677,0050661,0051870,0051871,0070401,0070402 P0ABQ4 35562546 203 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 7nae A 2.35 BS01 TOP A 1 I5 A6 W22 D27 F31 I94 I5 A6 W22 D27 F31 I94 1.5.1.3 0004146,0005515,0005542,0005829,0006730,0009257,0009410,0016491,0031427,0046452,0046654,0046655,0046656,0046677,0050661,0051870,0051871,0070401,0070402 P0ABQ4 35562546 201 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 7r6g A 2.61 BS01 TOP A 1 M6 A7 A8 E28 Q29 F32 M51 L54 M6 A7 A8 E28 Q29 F32 M51 L54 1.5.1.3 0004146,0005829,0006730,0016491,0031427,0046452,0046654,0046655,0046677,0050661 P11731 35562546 201 MKVSLMAAKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMGALPNRKYAVVTRSAWTADNDNVIVFPSIEEAMYGLAELTDHVIVSGGGEIYRETLPMASTLHISTIDIEPEGDVFFPNIPNTFEVVFEQHFSSNINYCYQIWQKG 7r6g B 2.61 BS01 TOP B 1 M6 A7 A8 E28 F32 M51 L54 M6 A7 A8 E28 F32 M51 L54 1.5.1.3 0004146,0005829,0006730,0016491,0031427,0046452,0046654,0046655,0046677,0050661 P11731 35562546 201 MKVSLMAAKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMGALPNRKYAVVTRSAWTADNDNVIVFPSIEEAMYGLAELTDHVIVSGGGEIYRETLPMASTLHISTIDIEPEGDVFFPNIPNTFEVVFEQHFSSNINYCYQIWQKG 8sze A 2.5 BS01 TOP A 1 I6 A7 A8 D28 F32 M95 I8 A9 A10 D21 F25 M88 1.5.1.3 0004146,0005829,0006730,0016491,0046452,0046654,0046655,0046872,0050661 A0A3N4BLI0 201 GGMIISLIAALAADRVILPADLAWFKRNTLNKPVIMGRKTFESIGRPLPGRLNIVISSQPGTDERVTWAASIEEALAFAGNAEEVMVMGGGRVYKQFLDRANRMYLTHIDAEVTHFPDYEPDEWESVFSEFHDADEANSHSYCFEILERR 8sze B 2.5 BS01 TOP B 1 I6 A7 H24 D28 L29 F32 M95 I7 A8 H17 D21 L22 F25 M88 1.5.1.3 0004146,0005829,0006730,0016491,0046452,0046654,0046655,0046872,0050661 A0A3N4BLI0 201 GMIISLIAALAADRVIHLPADLAWFKRNTLNKPVIMGRKTFESIGRPLPGRLNIVISSQPGTDERVTWAASIEEALAFAGNAEEVMVMGGGRVYKQFLDRANRMYLTHIDAEVTHFPDYEPDEWESVFSEFHDADEANSHSYCFEILERR