1b6a A 1.6 BS03 TN4 A 1 H231 N327 L328 N329 H331 I338 H339 Y444 H108 N204 L205 N206 H208 I215 H216 Y321 D251 D262 H331 H339 E364 E459 D128 D139 H208 H216 E241 E336 3.4.11.18 0003723,0004177,0004239,0005515,0005737,0005829,0005886,0006508,0008235,0016485,0018206,0031365,0046872,0070006 IC50=1nM, Ki=1nM P50579 9812898 480 KVQTDPPSVPICDLYPNGVFPKGQECEYPEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY 3fmr A 2.89 BS03 TN4 A 1 F97 H109 D206 L207 H208 H218 Y324 F95 H107 D204 L205 H206 H216 Y322 D130 D141 H210 H218 E243 E339 D128 D139 H208 H216 E241 E337 3.4.11.18 0004177,0004239,0005737,0006508,0008235,0046872,0070006 -logKd/Ki=7.97, IC50=10.6nM Q8SR45 19660503 451 CILLNQAEELPIEFLPKDGVYGKGKLFDSRNMEIENFTESDILQDARRAAEAHRRARYRVQSIVRPGITLLEIVRSIEDSTRTLLKGERNNGIGFPAGMSMNSCAAHYTVNPGEQDIVLKEDDVLKIDFGTHSDGRIMDSAFTVAFKENLEPLLVAAREGTETGIKSLGVDVRVCDIGRDINEVISSYEVEIGGRMWPIRPISDLHGHSISQFRIHGGISIPAVNNRDTTRIKGDSFYAVETFATTGKGSIDDRPPCSHFVLNTYKSRKLFNKDLIKVYEFVKDSLGTLPFSPRHLDYYGLVKGGSLKSVNLLTMMGLLTPYPPLNDIDGCKVAQFEHTVYLSEHGKEVLTRGDDY 3fmr B 2.89 BS03 TN4 B 1 F97 H109 D206 L207 H208 P292 Y324 F95 H107 D204 L205 H206 P290 Y322 D130 D141 H210 H218 E243 E339 D128 D139 H208 H216 E241 E337 3.4.11.18 0004177,0004239,0005737,0006508,0008235,0046872,0070006 Q8SR45 19660503 451 CILLNQAEELPIEFLPKDGVYGKGKLFDSRNMEIENFTESDILQDARRAAEAHRRARYRVQSIVRPGITLLEIVRSIEDSTRTLLKGERNNGIGFPAGMSMNSCAAHYTVNPGEQDIVLKEDDVLKIDFGTHSDGRIMDSAFTVAFKENLEPLLVAAREGTETGIKSLGVDVRVCDIGRDINEVISSYEVEIGGRMWPIRPISDLHGHSISQFRIHGGISIPAVNNRDTTRIKGDSFYAVETFATTGKGSIDDRPPCSHFVLNTYKSRKLFNKDLIKVYEFVKDSLGTLPFSPRHLDYYGLVKGGSLKSVNLLTMMGLLTPYPPLNDIDGCKVAQFEHTVYLSEHGKEVLTRGDDY 5yr4 A 1.82 BS04 TN4 A 1 P192 Y195 H212 Y300 C301 M309 H310 E336 P103 Y106 H123 Y211 C212 M220 H221 E247 3.4.11.18 0006508,0070006 -logKd/Ki=6.34, Ki=0.46uM P53582 30837307 410 YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLMHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS 5yr6 A 1.75 BS03 TN4 A 1 P192 Y195 H212 Y300 C301 H310 E336 W353 P103 Y106 H123 Y211 C212 H221 E247 W264 3.4.11.18 0006508,0070006 -logKd/Ki=5.34, Ki=4.57uM P53582 30837307 410 YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLLHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS