1evk B 2.0 BS02 THR B 1 Q381 D383 Y462 Q484 Q140 D142 Y221 Q243 C334 R363 Q381 D383 H385 K465 H511 C93 R122 Q140 D142 H144 K224 H270 6.1.1.3 0000166,0004812,0004829,0005524,0005737,0006418,0006435 P0A8M3 10881191 801 RDHRKIGKQLDLYHMQEEAPGMVFWHNDGWTIFRELEVFVRSKLKEYQYQEVKGPFMMDRVLWEKTGHWDNYKDAMFTTSSENREYCIKPMNCPGHVQIFNQGLKSYRDLPLRMAEFGSCHRNEPSGSLHGLMRVRGFTQDDAHIFCTEEQIRDEVNGCIRLVYDMYSTFGFEKIVVKLSTRPEKRIGSDEMWDRAEADLAVALEENNIPFEYQLGEGAFYGPKIEFTLYDCLDRAWQCGTVQLDFSLPSRLSASYVGEDNERKVPVMIHRAILGSMERFIGILTEEFAGFFPTWLAPVQVVIMNITDSQSEYVNELTQKLSNAGIRVKADLRNEKIGFKIREHTLRRVPYMLVCGDKEVESGKVAVRTRRGKDLGSMDVNEVIEKLQQEIRSRSLKQLEE 1h73 A 2.0 BS01 THR A 1 N17 D23 R187 R235 N13 D19 R183 R231 E130 T183 E126 T179 2.7.1.39 0004413,0005524,0005737,0006566,0009088,0016301,0016310 Q58504 11535056 401 MKVRVKAPCTSANLGVGFDVFGLCLKEPYDVIEVEAIDDKEIIIEVDDKNIPTDPDKNVAGIVAKKMIDDFNIGKGVKITIKKGVKAGSGLGSSAASSAGTAYAINELFKLNLDKLKLVDYASYGELASSGAKHADNVAPAIFGGFTMVTNYEPLEVLHIPIDFKLDILIAIPNISINTKEAREILPKAVGLKDLVNNVGKACGMVYALYNKDKSLFGRYMMSDKVIEPVRGKLIPNYFKIKEEVKDKVYGITISGSGPSIIAFPKEEFIDEVENILRDYYENTIRTEVGKGVEVV 1kjo A 1.6 BS06 THR A 1 N112 A113 H142 E143 E166 H231 N112 A113 H142 E143 E166 H231 H142 E143 H146 Y157 E166 D226 H231 H142 E143 H146 Y157 E166 D226 H231 3.4.24.27 0004222,0006508 P00800 1317 ITGTSTVGVGRGVLGDQKNINTTYSTYYYLQDNTRGNGIFTYDAKYRTTLPGSLWADADNQFFASYDAPAVDAHYYAGVTYDYYKNVHNRLSYDGNNAAIRSSVHYSQGYNNAFWNGSQMVYGDGDGQTFIPLSGGIDVVAHELTHAVTDYTAGLIYQNESGAINEAISDIFGTLVEFYANKNPDWEIGEDVYTPGISGDSLRSMSDPAKYGDPDHYSKRYTGTQDNGGVHINSGIINKAAYLISQGGTHYGVSVVGIGRDKLGKIFYRALTQYLTPTSNFSQLRAAAVQSATDLYGSTSQEVASVKQAFDAVGVK 1nyr A 2.8 BS04 THR A 1 M334 C336 D385 H387 H517 M331 C333 D382 H384 H514 C336 R365 L383 D385 H387 K471 H517 C333 R362 L380 D382 H384 K468 H514 6.1.1.3 0000049,0000166,0004812,0004829,0005524,0005737,0006412,0006418,0006435,0016740,0043039,0046872 Q8NW68 12875846 1004 INIQFPDGNKKAFDKGTTTEDIAQSISPGLRKKAVAGKFNGQLVDLTKPLETDGSIEIVTPGSEEALEVLRHSTAHLMAHAIKRLYGNVKFGVGPVIEGGFYYDFDIDQNISSDDFEQIEKTMKQIVNENMKIERKVVSRDEAKELFSNDEYKLELIDAIPEDENVTLYSQGDFTDLCRGVHVPSTAKIKEFKLLSTAGAYWRGDSNNKMLQRIYGTAFFDKKELKAHLQMLEERKERDHRKIGKELELFTNSQLVGAGLPLWLPNGATIRREIERYIVDKEVSMGYDHVYTPVLANVDLYKTSGHWDHYQEDMFPPMQLDETESMVLRPMNCPHHMMIYANKPHSYRELPIRIAELGTMHRYEASGAVSGLQRVRGMTLNDSHIFVRPDQIKEEFKRVVNMIIDVYKDFGFEDYSFRLSYRDPEDKEKYFDDDDMWNKAENMLKEAADELGLSYEEAIGEAAFYGPKLDVQVKTAMGKEETLSTAQLDFLLPERFDLTYIGQDGEHHRPVVIHRGVVSTMERFVAFLTEETKGAFPTWLAPKQVQIIPVNVDLHYDYARQLQDELKSQGVRVSIDDRNEKMGYKIREAQMQKIPYQIVVGDKEVENNQVNVRQYGSQDQETVEKDEFIWNLVDEIRLKKHR 1nyr B 2.8 BS03 THR B 1 M334 C336 D385 H517 M326 C328 D377 H509 C336 R365 L383 D385 H387 K471 H517 C328 R357 L375 D377 H379 K463 H509 6.1.1.3 0000049,0000166,0004812,0004829,0005524,0005737,0006412,0006418,0006435,0016740,0043039,0046872 Q8NW68 12875846 2004 MEQINIQFPDGNKKAFDKGTTTEDIAQSISPGLRKKAVAGKFNGQLVDLTKPLETDGSIEIVTPGSEEALEVLRHSTAHLMAHAIKRLYGNVKFGVGPVIEGGFYYDFDIDQNISSDDFEQIEKTMKQIVNENMKIERKVVSRDEAKELELIDAIPEDENVTLYSQGDFTDLCRGVHVPSTAKIKEFKLLSTAGAYWRGDSNNKMLQRIYGTAFFDKKELKAHLQMLEERKERDHRKIGKELELFTNSQLVGAGLPLWLPNGATIRREIERYIVDKEVSMGYDHVYTPVLANVDLYKTSGHWDHYQEDMFPPMQLDETESMVLRPMNCPHHMMIYANKPHSYRELPIRIAELGTMHRYEASGAVSGLQRVRGMTLNDSHIFVRPDQIKEEFKRVVNMIIDVYKDFGFEDYSFRLSYRDPEDKEKYFDDDDMWNKAENMLKEAADELGLSYEEAIGEAAFYGPKLDVQVKTAMGKEETLSTAQLDFLLPERFDLTYIGQDGEHHRPVVIHRGVVSTMERFVAFLTEETKGAFPTWLAPKQVQIIPVNVDLHYDYARQLQDELKSQGVRVSIDDRNEKMGYKIREAQMQKIPYQIVVGDKEVENNQVNVRQYGSQDQETVEKDEFIWNLVDEIRLKKHR 1oew A 0.9 BS02 THR A 1 G37 S77 G37 S76 D35 S38 D40 W42 G79 T219 T222 D35 S38 D40 W42 G78 T218 T221 3.4.23.22 0004190,0006508 P11838 12876323 402 STGSATTTPIDSLDDAYITPVQIGTPAQTLNLDFDTGSSDLWVFSSETTASEVQTIYTPSKSTTAKLLSGATWSISYGDGSSSSGDVYTDTVSVGGLTVTGQAVESAKKVSSSFTEDSTIDGLLGLAFSTLNTVSPTQQKTFFDNAKASLDSPVFTADLGYHAPGTYNFGFIDTTAYTGSITYTAVSTKQGFWEWTSTGYAVGSGTFKSTSIDGIADTGTTLLYLPATVVSAYWAQVSGAKSSSSVGGYVFPCSATLPSFTFGVGSARIVIPGDYIDFGPISTGSSSCFGGIQSSAGIGINIFGDVALKAAFVVFNGATTPTLGFASK 2dt9 A 2.15 BS01 THR B 1 Q27 I30 A31 Q50 Q23 I26 A27 Q46 2.7.2.4 P61489 19490113 401 KAVTGVALDLDHAQIGLIGIPDQPGIAAKVFQALAERGIAVDMIIQGVPGHDPSRQQMAFTVKKDFAQEALEALEPVLAEIGGEAILRPDIAKVSIVGVGLASTPEVPAKMFQAVASTGANIEMIATSEVRISVIIPAEYAEAALRAVHQAFE 2dt9 A 2.15 BS02 THR B 2 N125 I126 N121 I122 2.7.2.4 P61489 19490113 402 KAVTGVALDLDHAQIGLIGIPDQPGIAAKVFQALAERGIAVDMIIQGVPGHDPSRQQMAFTVKKDFAQEALEALEPVLAEIGGEAILRPDIAKVSIVGVGLASTPEVPAKMFQAVASTGANIEMIATSEVRISVIIPAEYAEAALRAVHQAFE 2dt9 B 2.15 BS01 THR B 1 N125 I126 N121 I122 2.7.2.4 P61489 19490113 401 KAVTGVALDLDHAQIGLIGIPDQPGIAAKVFQALAERGIAVDMIIQGVPGHDPSRQQMAFTVKKDFAQEALEALEPVLAEIGGEAILRPDIAKVSIVGVGLASTPEVPAKMFQAVASTGANIEMIATSEVRISVIIPAEYAEAALRAVHQAFE 2dt9 B 2.15 BS02 THR B 2 Q27 G29 I30 A31 Q50 Q23 G25 I26 A27 Q46 2.7.2.4 P61489 19490113 402 KAVTGVALDLDHAQIGLIGIPDQPGIAAKVFQALAERGIAVDMIIQGVPGHDPSRQQMAFTVKKDFAQEALEALEPVLAEIGGEAILRPDIAKVSIVGVGLASTPEVPAKMFQAVASTGANIEMIATSEVRISVIIPAEYAEAALRAVHQAFE 2dtj A 1.58 BS01 THR A 1 K26 G28 E29 A30 Q49 K23 G25 E26 A27 Q46 2.7.2.4 P26512 17350037 401 AVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVSSVEDGTTDITFTCPRSDGRRAMEILKKLQVQGNWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQLGGEDEAVVY 2dtj A 1.58 BS02 THR B 1 N125 I126 N122 I123 2.7.2.4 P26512 17350037 402 AVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVSSVEDGTTDITFTCPRSDGRRAMEILKKLQVQGNWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQLGGEDEAVVY 2dtj B 1.58 BS01 THR A 1 N125 I126 N124 I125 2.7.2.4 P26512 17350037 401 EEAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVSSVEDGTTDITFTCPRSDGRRAMEILKKLQVQGNWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQLEAVVYA 2dtj B 1.58 BS02 THR B 1 K26 E29 A30 Q49 K25 E28 A29 Q48 2.7.2.4 P26512 17350037 402 EEAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVSSVEDGTTDITFTCPRSDGRRAMEILKKLQVQGNWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQLEAVVYA 3a9w A 1.85 BS01 THR A 1 S74 T112 F137 G177 T178 T179 S74 T112 F137 G177 T178 T179 1.1.1.103 0000166,0006567,0008743 Q97BK3 22374996 318 MILVTGSSGQIGTELVPYLAEKYGKKNVIASDIVQRDTGGIKFITLDVSNRDEIDRAVEKYSIDAIFHLAGILSAKGEKDPALAYKVNMNGTYNILEAAKQHRVEKVVIPSTIGVFGPETPKNKVPSITITRPRTMFGVTKIAAELLGQYYYEKFGLDVRSLRYPGIISYKAEPTAGTTDYAVEIFYYAVKREKYKCYLAPNRALPMMYMPDALKALVDLYEADRDKLVLRNGYNVTAYTFTPSELYSKIKERIPEFEIEYKEDFRDKIAATWPESLDSSEASNEWGFSIEYDLDRTIDDMIDHISEKLGIEGKH 3a9w B 1.85 BS01 THR B 1 S74 P165 T178 T179 S74 P165 T178 T179 1.1.1.103 0000166,0006567,0008743 Q97BK3 22374996 318 MILVTGSSGQIGTELVPYLAEKYGKKNVIASDIVQRDTGGIKFITLDVSNRDEIDRAVEKYSIDAIFHLAGILSAKGEKDPALAYKVNMNGTYNILEAAKQHRVEKVVIPSTIGVFGPETPKNKVPSITITRPRTMFGVTKIAAELLGQYYYEKFGLDVRSLRYPGIISYKAEPTAGTTDYAVEIFYYAVKREKYKCYLAPNRALPMMYMPDALKALVDLYEADRDKLVLRNGYNVTAYTFTPSELYSKIKERIPEFEIEYKEDFRDKIAATWPESLDSSEASNEWGFSIEYDLDRTIDDMIDHISEKL 3aaw A 2.5 BS01 THR A 1 K275 G277 E278 A279 Q298 K253 G255 E256 A257 Q276 2.7.2.4 0004072,0005524,0005829,0008652,0009085,0009088,0009089,0009090,0016301,0016310,0019877 P26512 20573952 501 ALVVQKYGGSSLESAERIRNVAERIVATKKAGNDVVVVCSAMGDTTDELLELAAAVNPVPPAREMDMLLTAGERISNALVAMAIESLGAEAQSFTVTPGRVREALDEGKICIVAGFVNKETRDVTTLGRGGSDTTAVALAAALNADVCEIYSDVDGVYTADPRIVPNAQKLEKLSFEEMLELAAVGSKILVLRSVEYARAFNVPLRVRSSYSNDPGTLIAGSMEDIPVEEAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVSSVEDGTTDITFTCPRSDGRRAMEILKKLQVQGNWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQLGG 3aaw A 2.5 BS03 THR B 1 N374 I375 N352 I353 2.7.2.4 0004072,0005524,0005829,0008652,0009085,0009088,0009089,0009090,0016301,0016310,0019877 P26512 20573952 201 ALVVQKYGGSSLESAERIRNVAERIVATKKAGNDVVVVCSAMGDTTDELLELAAAVNPVPPAREMDMLLTAGERISNALVAMAIESLGAEAQSFTVTPGRVREALDEGKICIVAGFVNKETRDVTTLGRGGSDTTAVALAAALNADVCEIYSDVDGVYTADPRIVPNAQKLEKLSFEEMLELAAVGSKILVLRSVEYARAFNVPLRVRSSYSNDPGTLIAGSMEDIPVEEAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVSSVEDGTTDITFTCPRSDGRRAMEILKKLQVQGNWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQLGG 3aaw B 2.5 BS01 THR A 1 N125 I126 N125 I126 2.7.2.4 0004072,0005829,0009088,0009089,0009090,0016301,0016310,0016740 Q93C54 20573952 501 MEEAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVSSVEDGTTDITFTCPRSDGRRAMEILKKLQVQGNWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQLGG 3aaw B 2.5 BS03 THR B 1 K26 E29 A30 Q49 K26 E29 A30 Q49 2.7.2.4 0004072,0005829,0009088,0009089,0009090,0016301,0016310,0016740 Q93C54 20573952 201 MEEAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVSSVEDGTTDITFTCPRSDGRRAMEILKKLQVQGNWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQLGG 3aaw C 2.5 BS02 THR C 1 K275 G277 E278 A279 Q298 K258 G260 E261 A262 Q281 2.7.2.4 0004072,0005524,0005829,0008652,0009085,0009088,0009089,0009090,0016301,0016310,0019877 P26512 20573952 501 MALVVQKYGGSSLESAERIRNVAERIVATKKAGNDVVVVCSAMGDTTDELLELAAAVNPVPPAREMDMLLTAGERISNALVAMAIESLGAEAQSFTGSQDVTPGRVREALDEGKICIVAGFQGVNKRDVTTLGRGGSDTTAVALAAALNADVCEIYSDVDGVYTADPRIVPNAQKLEKLSFEEMLELAAVGSKILVLRSVEYARAFNVPLRVRSSYSNDPGTLIAGSMEDIPVEEAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVSSVEDGTTDITFTCPRSDGRRAMEILKKLQVQGNWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQLGG 3aaw C 2.5 BS04 THR D 1 N374 I375 N357 I358 2.7.2.4 0004072,0005524,0005829,0008652,0009085,0009088,0009089,0009090,0016301,0016310,0019877 P26512 20573952 201 MALVVQKYGGSSLESAERIRNVAERIVATKKAGNDVVVVCSAMGDTTDELLELAAAVNPVPPAREMDMLLTAGERISNALVAMAIESLGAEAQSFTGSQDVTPGRVREALDEGKICIVAGFQGVNKRDVTTLGRGGSDTTAVALAAALNADVCEIYSDVDGVYTADPRIVPNAQKLEKLSFEEMLELAAVGSKILVLRSVEYARAFNVPLRVRSSYSNDPGTLIAGSMEDIPVEEAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVSSVEDGTTDITFTCPRSDGRRAMEILKKLQVQGNWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQLGG 3aaw D 2.5 BS02 THR C 1 N125 I126 N125 I126 2.7.2.4 0004072,0005829,0009088,0009089,0009090,0016301,0016310,0016740 Q93C54 20573952 501 MEEAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVSSVEDGTTDITFTCPRSDGRRAMEILKKLQVQGNWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQLG 3aaw D 2.5 BS03 THR D 1 K26 E29 A30 Q49 K26 E29 A30 Q49 2.7.2.4 0004072,0005829,0009088,0009089,0009090,0016301,0016310,0016740 Q93C54 20573952 201 MEEAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVSSVEDGTTDITFTCPRSDGRRAMEILKKLQVQGNWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQLG 3ab2 A 2.59 BS01 THR A 1 D274 K275 G277 E278 A279 Q298 D252 K253 G255 E256 A257 Q276 2.7.2.4 0004072,0005524,0005829,0008652,0009085,0009088,0009089,0009090,0016301,0016310,0019877 P26512 20573952 501 ALVVQKYGGSSLESAERIRNVAERIVATKKAGNDVVVVCSAMGDTTDELLELAAAVNPVPPAREMDMLLTAGERISNALVAMAIESLGAEAQSFTGSQAGVLVTPGRVREALDEGKICIVAGFQGVLGRGGSDTTAVALAAALNADVCEIYSDVDGVYTADPRIVPNAQKLEKLSFEEMLELAAVGSKILVLRSVEYARAFNVPLRVRSSYSNDPGTLIAGSMEDIPVEEAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVSSVEDGTTDITFTCPRSDGRRAMEILKKLQVGNWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQLGG 3ab2 A 2.59 BS02 THR B 1 N374 I375 N351 I352 2.7.2.4 0004072,0005524,0005829,0008652,0009085,0009088,0009089,0009090,0016301,0016310,0019877 P26512 20573952 501 ALVVQKYGGSSLESAERIRNVAERIVATKKAGNDVVVVCSAMGDTTDELLELAAAVNPVPPAREMDMLLTAGERISNALVAMAIESLGAEAQSFTGSQAGVLVTPGRVREALDEGKICIVAGFQGVLGRGGSDTTAVALAAALNADVCEIYSDVDGVYTADPRIVPNAQKLEKLSFEEMLELAAVGSKILVLRSVEYARAFNVPLRVRSSYSNDPGTLIAGSMEDIPVEEAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVSSVEDGTTDITFTCPRSDGRRAMEILKKLQVGNWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQLGG 3ab2 B 2.59 BS01 THR A 1 N125 I126 N125 I126 2.7.2.4 P26512 20573952 501 MEEAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVSSVEDGTTDITFTCPRSDGRRAMEILKKLQVQGNWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQLGG 3ab2 B 2.59 BS02 THR B 1 K26 E29 A30 Q49 K26 E29 A30 Q49 2.7.2.4 P26512 20573952 501 MEEAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVSSVEDGTTDITFTCPRSDGRRAMEILKKLQVQGNWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQLGG 3ab2 C 2.59 BS01 THR C 1 K275 P276 G277 E278 A279 Q298 K247 P248 G249 E250 A251 Q270 2.7.2.4 0004072,0005524,0005829,0008652,0009085,0009088,0009089,0009090,0016301,0016310,0019877 P26512 20573952 501 ALVVQKYGGSSLESAERIRNVAERIVATKKAGNDVVVVCSAMGDTTDELLELAAAVNPVPPAREMDMLLTAGERISNALVAMAIESLGAEAQSFTGSQAGVVDVTPGRVREALDEGKICIVAGFGSDTTAVALAAALNADVCEIYSDVDGVYTADPRIVPNAQKLEKLSFEEMLELAAVGSKILVLRSVEYARAFNVPLRVRSSYSNDPGTLIAGSMEDIPVEEAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVSSVEDGTTDITFTCPRSDGRRAMEILKKLQVQGNWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQLG 3ab2 C 2.59 BS02 THR D 1 N374 I375 N346 I347 2.7.2.4 0004072,0005524,0005829,0008652,0009085,0009088,0009089,0009090,0016301,0016310,0019877 P26512 20573952 501 ALVVQKYGGSSLESAERIRNVAERIVATKKAGNDVVVVCSAMGDTTDELLELAAAVNPVPPAREMDMLLTAGERISNALVAMAIESLGAEAQSFTGSQAGVVDVTPGRVREALDEGKICIVAGFGSDTTAVALAAALNADVCEIYSDVDGVYTADPRIVPNAQKLEKLSFEEMLELAAVGSKILVLRSVEYARAFNVPLRVRSSYSNDPGTLIAGSMEDIPVEEAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVSSVEDGTTDITFTCPRSDGRRAMEILKKLQVQGNWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQLG 3ab2 D 2.59 BS01 THR D 1 D25 K26 E29 A30 Q49 D22 K23 E26 A27 Q46 2.7.2.4 P26512 20573952 501 AVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVSSVEDGTTDITFTCPRSDGRRAMEILKKLQNWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQL 3ab2 E 2.59 BS01 THR E 1 D274 K275 G277 E278 A279 Q298 D249 K250 G252 E253 A254 Q273 2.7.2.4 0004072,0005524,0005829,0008652,0009085,0009088,0009089,0009090,0016301,0016310,0019877 P26512 20573952 501 ALVVQKYGGSSLESAERIRNVAERIVATKKAGNDVVVVCSAMGDTTDELLELAAAVNPVPPAREMDMLLTAGERISNALVAMAIESLGAEAQSFTGSQAGVLTVTPGRVREALDEGKICIVAGFQRGGSDTTAVALAAALNADVCEIYSDVDGVYTADPRIVPNAQKLEKLSFEEMLELAAVGSKILVLRSVEYARAFNVPLRVRSSYSNDPGTLIAGSMEDIPVEEAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVSSVEDGTTDITFTCPRSDGRRAMEILKKLQVQGNWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQLG 3ab2 E 2.59 BS02 THR F 1 N374 I375 N349 I350 2.7.2.4 0004072,0005524,0005829,0008652,0009085,0009088,0009089,0009090,0016301,0016310,0019877 P26512 20573952 501 ALVVQKYGGSSLESAERIRNVAERIVATKKAGNDVVVVCSAMGDTTDELLELAAAVNPVPPAREMDMLLTAGERISNALVAMAIESLGAEAQSFTGSQAGVLTVTPGRVREALDEGKICIVAGFQRGGSDTTAVALAAALNADVCEIYSDVDGVYTADPRIVPNAQKLEKLSFEEMLELAAVGSKILVLRSVEYARAFNVPLRVRSSYSNDPGTLIAGSMEDIPVEEAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVSSVEDGTTDITFTCPRSDGRRAMEILKKLQVQGNWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQLG 3ab2 F 2.59 BS01 THR E 1 N125 I126 N122 I123 2.7.2.4 P26512 20573952 501 EAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVSSVEDGTTDITFTCPRSDGRRAMEILKKLQVQGWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQL 3ab2 F 2.59 BS02 THR F 1 K26 E29 A30 Q49 K24 E27 A28 Q47 2.7.2.4 P26512 20573952 501 EAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVSSVEDGTTDITFTCPRSDGRRAMEILKKLQVQGWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQL 3ab2 G 2.59 BS01 THR G 1 D274 K275 E278 A279 Q298 D249 K250 E253 A254 Q273 2.7.2.4 0004072,0005524,0005829,0008652,0009085,0009088,0009089,0009090,0016301,0016310,0019877 P26512 20573952 501 MALVVQKYGGSSLESAERIRNVAERIVATKKAGNDVVVVCSAMGDTTDELLELAAAVNPVPPAREMDMLLTAGERISNALVAMAIESLGAEAQSFTGSQAGVVDVTPGRVREALDEGKICIVAGFRGGSDTTAVALAAALNADVCEIYSDVDGVYTADPRIVPNAQKLEKLSFEEMLELAAVGSKILVLRSVEYARAFNVPLRVRSSYSNDPGTLIAGSMEDIPVEEAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVSSVEDGTTDITFTCPRSDGRRAMEILKKLQVQGNWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQLG 3ab2 G 2.59 BS02 THR H 1 N374 I375 N349 I350 2.7.2.4 0004072,0005524,0005829,0008652,0009085,0009088,0009089,0009090,0016301,0016310,0019877 P26512 20573952 501 MALVVQKYGGSSLESAERIRNVAERIVATKKAGNDVVVVCSAMGDTTDELLELAAAVNPVPPAREMDMLLTAGERISNALVAMAIESLGAEAQSFTGSQAGVVDVTPGRVREALDEGKICIVAGFRGGSDTTAVALAAALNADVCEIYSDVDGVYTADPRIVPNAQKLEKLSFEEMLELAAVGSKILVLRSVEYARAFNVPLRVRSSYSNDPGTLIAGSMEDIPVEEAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVSSVEDGTTDITFTCPRSDGRRAMEILKKLQVQGNWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQLG 3ab2 H 2.59 BS01 THR G 1 N125 I126 N122 I123 2.7.2.4 P26512 20573952 501 EEAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVSSVEDGTTDITFTCPRSDGRRAMEILKKLQVNWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQL 3ab2 H 2.59 BS02 THR H 1 I23 D25 K26 A30 Q49 I22 D24 K25 A29 Q48 2.7.2.4 P26512 20573952 501 EEAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVSSVEDGTTDITFTCPRSDGRRAMEILKKLQVNWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQL 3ab2 I 2.59 BS01 THR J 1 N374 I375 N342 I343 2.7.2.4 0004072,0005524,0005829,0008652,0009085,0009088,0009089,0009090,0016301,0016310,0019877 P26512 20573952 501 ALVVQKYGGSSLESAERIRNVAERIVATKKAGNDVVVVCSAMGDTTDELLELAAAVNPVPPAREMDMLLTAGERISNALVAMAIESLGAEAQSFTGSQAGVLPGRVREALDEGKICIVAGFSDTTAVALAAALNADVCEIYSDVDGVYTADPRIVPNAQKLEKLSFEEMLELAAVGSKILVLRSVEYARAFNVPLRVRSSYSNDPGTLIAGSMEDIPVEEAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVSSVEDGTTDITFTCPRSDGRRAMEILKKLQVQGNWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQLGG 3ab2 J 2.59 BS01 THR J 1 D25 K26 P27 G28 A30 Q49 D23 K24 P25 G26 A28 Q47 2.7.2.4 P26512 20573952 501 EAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVSSVEDGTTDITFTCPRSDGRRAMEILKKLQVNWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQF 3ab2 K 2.59 BS01 THR K 1 D274 K275 G277 E278 A279 Q298 D247 K248 G250 E251 A252 Q271 2.7.2.4 0004072,0005524,0005829,0008652,0009085,0009088,0009089,0009090,0016301,0016310,0019877 P26512 20573952 501 ALVVQKYGGSSLESAERIRNVAERIVATKKAGNDVVVVCSAMGDTTDELLELAAAVNPVPPAREMDMLLTAGERISNALVAMAIESLGAEAQSFTGSQAGVLTVTPGRVREALDEGKICIVAGFRGGSDTTAVALAAALNADVCEIYSDVDGVYTADPRIVPNAQKLEKLSFEEMLELAAVGSKILVLRSVEYARAFNVPLRVRSSYSDPGTLIAGSMEDIPVEEAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVSSVEDGTTDITFTCPRSDGRRAMEILKKLQVQGNWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQLGG 3ab2 K 2.59 BS02 THR L 1 N374 I375 N347 I348 2.7.2.4 0004072,0005524,0005829,0008652,0009085,0009088,0009089,0009090,0016301,0016310,0019877 P26512 20573952 501 ALVVQKYGGSSLESAERIRNVAERIVATKKAGNDVVVVCSAMGDTTDELLELAAAVNPVPPAREMDMLLTAGERISNALVAMAIESLGAEAQSFTGSQAGVLTVTPGRVREALDEGKICIVAGFRGGSDTTAVALAAALNADVCEIYSDVDGVYTADPRIVPNAQKLEKLSFEEMLELAAVGSKILVLRSVEYARAFNVPLRVRSSYSDPGTLIAGSMEDIPVEEAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVSSVEDGTTDITFTCPRSDGRRAMEILKKLQVQGNWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQLGG 3ab2 L 2.59 BS01 THR K 1 N125 I126 N119 I120 2.7.2.4 P26512 20573952 501 AVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVSSVEDGTTDITFTCPRSDGRRAMEILKKLQVWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQL 3ab2 L 2.59 BS02 THR L 1 D25 K26 G28 E29 A30 Q49 D22 K23 G25 E26 A27 Q46 2.7.2.4 P26512 20573952 501 AVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVSSVEDGTTDITFTCPRSDGRRAMEILKKLQVWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQL 3ab2 M 2.59 BS01 THR M 1 D274 K275 G277 E278 A279 Q298 D248 K249 G251 E252 A253 Q272 2.7.2.4 0004072,0005524,0005829,0008652,0009085,0009088,0009089,0009090,0016301,0016310,0019877 P26512 20573952 501 ALVVQKYGGSSLESAERIRNVAERIVATKKAGNDVVVVCSAMGDTTDELLELAAAVNPVPPAREMDMLLTAGERISNALVAMAIESLGAEAQSFTGSQAGVLVTPGRVREALDEGKICIVAGFGRGGSDTTAVALAAALNADVCEIYSDVDGVYTADPRIVPNAQKLEKLSFEEMLELAAVGSKILVLRSVEYARAFNVPLRVRSSYSNDPGTLIAGSMEDIPVEEAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVSSVEDGTTDITFTCPRSDGRRAMEILKKLQVNWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQLG 3ab2 M 2.59 BS02 THR N 1 N374 I375 N346 I347 2.7.2.4 0004072,0005524,0005829,0008652,0009085,0009088,0009089,0009090,0016301,0016310,0019877 P26512 20573952 501 ALVVQKYGGSSLESAERIRNVAERIVATKKAGNDVVVVCSAMGDTTDELLELAAAVNPVPPAREMDMLLTAGERISNALVAMAIESLGAEAQSFTGSQAGVLVTPGRVREALDEGKICIVAGFGRGGSDTTAVALAAALNADVCEIYSDVDGVYTADPRIVPNAQKLEKLSFEEMLELAAVGSKILVLRSVEYARAFNVPLRVRSSYSNDPGTLIAGSMEDIPVEEAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVSSVEDGTTDITFTCPRSDGRRAMEILKKLQVNWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQLG 3ab2 N 2.59 BS01 THR N 1 K26 G28 A30 Q49 K24 G26 A28 Q47 2.7.2.4 P26512 20573952 501 EAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVSSVEDGTTDITFTCPRSDGRRAMEILKKLQVQGNWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQ 3ab2 O 2.59 BS01 THR O 1 K275 A279 Q298 K250 A254 Q273 2.7.2.4 0004072,0005524,0005829,0008652,0009085,0009088,0009089,0009090,0016301,0016310,0019877 P26512 20573952 501 ALVVQKYGGSSLESAERIRNVAERIVATKKAGNDVVVVCSAMGDTTDELLELAAAVNPVPPAREMDMLLTAGERISNALVAMAIESLGAEAQSFTGSQAGVLTTPGRVREALDEGKICIVAGFQGRGGSDTTAVALAAALNADVCEIYSDVDGVYTADPRIVPNAQKLEKLSFEEMLELAAVGSKILVLRSVEYARAFNVPLRVRSSYSNDPGTLIAGSMEDIPVEEAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVSSVEDGTTDITFTCPRSDGRRAMEILKKLQVQGNWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQLGGED 3ab2 O 2.59 BS02 THR P 1 N374 I375 N349 I350 2.7.2.4 0004072,0005524,0005829,0008652,0009085,0009088,0009089,0009090,0016301,0016310,0019877 P26512 20573952 501 ALVVQKYGGSSLESAERIRNVAERIVATKKAGNDVVVVCSAMGDTTDELLELAAAVNPVPPAREMDMLLTAGERISNALVAMAIESLGAEAQSFTGSQAGVLTTPGRVREALDEGKICIVAGFQGRGGSDTTAVALAAALNADVCEIYSDVDGVYTADPRIVPNAQKLEKLSFEEMLELAAVGSKILVLRSVEYARAFNVPLRVRSSYSNDPGTLIAGSMEDIPVEEAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVSSVEDGTTDITFTCPRSDGRRAMEILKKLQVQGNWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQLGGED 3ab2 P 2.59 BS01 THR O 1 N125 I126 N125 I126 2.7.2.4 P26512 20573952 501 MEEAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVSSVEDGTTDITFTCPRSDGRRAMEILKKLQVQGNWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQLG 3ab2 P 2.59 BS02 THR P 1 K26 E29 A30 Q49 K26 E29 A30 Q49 2.7.2.4 P26512 20573952 501 MEEAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVSSVEDGTTDITFTCPRSDGRRAMEILKKLQVQGNWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQLG 3ab4 A 2.47 BS01 THR A 1 K275 G277 E278 A279 Q298 K239 G241 E242 A243 Q262 2.7.2.4 0004072,0005524,0005829,0008652,0009085,0009088,0009089,0009090,0016301,0016310,0019877 P26512 20573952 501 ALVVQKYGGSSLESAERIRNVAERIVATKKAGNDVVVVCSAMGDTTDELLELAAAVNPVPPAREMDMLLTAGERISNALVAMAIESLGAEAQSFTGSVTPGRVREALDEGKICIVGGSDTTAVALAAALNADVCEIYSDVDGVYTADPRIVPNAQKLEKLSFEEMLELAAVGSKILVLRSVEYARAFNVPLRVRSSYSNDPGTLIAGSMEDIPVEEAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVFSDGTTDITFTCPRSDGRRAMEILKKLQVQGNWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQLG 3ab4 A 2.47 BS03 THR B 1 N374 I375 N336 I337 2.7.2.4 0004072,0005524,0005829,0008652,0009085,0009088,0009089,0009090,0016301,0016310,0019877 P26512 20573952 201 ALVVQKYGGSSLESAERIRNVAERIVATKKAGNDVVVVCSAMGDTTDELLELAAAVNPVPPAREMDMLLTAGERISNALVAMAIESLGAEAQSFTGSVTPGRVREALDEGKICIVGGSDTTAVALAAALNADVCEIYSDVDGVYTADPRIVPNAQKLEKLSFEEMLELAAVGSKILVLRSVEYARAFNVPLRVRSSYSNDPGTLIAGSMEDIPVEEAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVFSDGTTDITFTCPRSDGRRAMEILKKLQVQGNWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQLG 3ab4 B 2.47 BS01 THR A 1 N125 I126 N118 I119 2.7.2.4 P26512 20573952 501 VLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVFSDGTTDITFTCPRSDGRRAMEILKKLQVGNWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQLGGEDEA 3ab4 B 2.47 BS03 THR B 1 D25 K26 A30 Q49 D21 K22 A26 Q45 2.7.2.4 P26512 20573952 201 VLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVFSDGTTDITFTCPRSDGRRAMEILKKLQVGNWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQLGGEDEA 3ab4 C 2.47 BS01 THR C 1 D274 K275 P276 A279 Q298 D236 K237 P238 A241 Q260 2.7.2.4 0004072,0005524,0005829,0008652,0009085,0009088,0009089,0009090,0016301,0016310,0019877 P26512 20573952 501 ALVVQKYGGSSLESAERIRNVAERIVATKKAGNDVVVVCSAMGDTTDELLELAAAVNPVPPAREMDMLLTAGERISNALVAMAIESLGAEAQSFTTPGRVREALDEGKICIVAGGSDTTAVALAAALNADVCEIYSDVDGVYTADPRIVPNAQKLEKLSFEEMLELAAVGSKILVLRSVEYARAFNVPLRVRSSYSNDPGTLIAGSMEDIPVEEAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVDGTTDITFTCPRSDGRRAMEILKKLQVQGNWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQLGG 3ab4 C 2.47 BS03 THR D 1 N374 I375 N332 I333 2.7.2.4 0004072,0005524,0005829,0008652,0009085,0009088,0009089,0009090,0016301,0016310,0019877 P26512 20573952 201 ALVVQKYGGSSLESAERIRNVAERIVATKKAGNDVVVVCSAMGDTTDELLELAAAVNPVPPAREMDMLLTAGERISNALVAMAIESLGAEAQSFTTPGRVREALDEGKICIVAGGSDTTAVALAAALNADVCEIYSDVDGVYTADPRIVPNAQKLEKLSFEEMLELAAVGSKILVLRSVEYARAFNVPLRVRSSYSNDPGTLIAGSMEDIPVEEAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVDGTTDITFTCPRSDGRRAMEILKKLQVQGNWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQLGG 3ab4 D 2.47 BS01 THR C 1 N125 I126 N118 I119 2.7.2.4 P26512 20573952 501 EAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVFDGTTDITFTCPRSDGRRAMEILKKLQVNWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQ 3ab4 D 2.47 BS03 THR D 1 K26 A30 Q49 K24 A28 Q47 2.7.2.4 P26512 20573952 201 EAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVFDGTTDITFTCPRSDGRRAMEILKKLQVNWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQ 3ab4 E 2.47 BS01 THR E 1 K275 P276 A279 Q298 K243 P244 A247 Q266 2.7.2.4 0004072,0005524,0005829,0008652,0009085,0009088,0009089,0009090,0016301,0016310,0019877 P26512 20573952 501 ALVVQKYGGSSLESAERIRNVAERIVATKKAGNDVVVVCSAMGDTTDELLELAAAVNPVPPAREMDMLLTAGERISNALVAMAIESLGAEAQSFTGTPGRVREALDEGKICIVAGFLGRGGSDTTAVALAAALNADVCEIYSDVDGVYTADPRIVPNAQKLEKLSFEEMLELAAVGSKILVLRSVEYARAFNVPLRVRSSYSNDPGTLIAGSMEDIPVEEAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNTTDITFTCPRSDGRRAMEILKKLQGNWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQLGG 3ab4 E 2.47 BS03 THR F 1 N374 I375 N333 I334 2.7.2.4 0004072,0005524,0005829,0008652,0009085,0009088,0009089,0009090,0016301,0016310,0019877 P26512 20573952 201 ALVVQKYGGSSLESAERIRNVAERIVATKKAGNDVVVVCSAMGDTTDELLELAAAVNPVPPAREMDMLLTAGERISNALVAMAIESLGAEAQSFTGTPGRVREALDEGKICIVAGFLGRGGSDTTAVALAAALNADVCEIYSDVDGVYTADPRIVPNAQKLEKLSFEEMLELAAVGSKILVLRSVEYARAFNVPLRVRSSYSNDPGTLIAGSMEDIPVEEAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNTTDITFTCPRSDGRRAMEILKKLQGNWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQLGG 3ab4 F 2.47 BS01 THR E 1 N125 I126 N117 I118 2.7.2.4 P26512 20573952 501 AVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVFDGTTDITFTCPRSDGRRAMEILKKLQVQWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQF 3ab4 F 2.47 BS03 THR F 1 D25 K26 A30 Q49 D22 K23 A27 Q46 2.7.2.4 P26512 20573952 201 AVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVFDGTTDITFTCPRSDGRRAMEILKKLQVQWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQF 3ab4 G 2.47 BS01 THR G 1 K275 A279 Q298 K232 A236 Q255 2.7.2.4 0004072,0005524,0005829,0008652,0009085,0009088,0009089,0009090,0016301,0016310,0019877 P26512 20573952 501 ALVVQKYGGSSLESAERIRNVAERIVATKKAGNDVVVVCSAMGDTTDELLELAAAVNPVPPAREMDMLLTAGERISNALVAMAIESLGAEAQSFTRVREALDEGKICIVAGGSDTTAVALAAALNADVCEIYSDVDGVYTADPRIVPNAQKLEKLSFEEMLELAAVGSKILVLRSVEYARAFNVPLRVRSSYSNDPGTLIAGSMEDIPVAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVFTTDITFTCPRSDGRRAMEILKKLQVQWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQL 3ab4 G 2.47 BS03 THR H 1 N374 I375 N324 I325 2.7.2.4 0004072,0005524,0005829,0008652,0009085,0009088,0009089,0009090,0016301,0016310,0019877 P26512 20573952 201 ALVVQKYGGSSLESAERIRNVAERIVATKKAGNDVVVVCSAMGDTTDELLELAAAVNPVPPAREMDMLLTAGERISNALVAMAIESLGAEAQSFTRVREALDEGKICIVAGGSDTTAVALAAALNADVCEIYSDVDGVYTADPRIVPNAQKLEKLSFEEMLELAAVGSKILVLRSVEYARAFNVPLRVRSSYSNDPGTLIAGSMEDIPVAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVFTTDITFTCPRSDGRRAMEILKKLQVQWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQL 3ab4 H 2.47 BS01 THR G 1 N125 I126 N118 I119 2.7.2.4 P26512 20573952 501 LTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVFSVEDGTTDITFTCPRSDGRRAMEILKKLQVQGNWTNVLYDDQVGKVSLVGAGMKPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQL 3ab4 H 2.47 BS03 THR H 1 K26 G28 E29 A30 Q49 K21 G23 E24 A25 Q44 2.7.2.4 P26512 20573952 201 LTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVFSVEDGTTDITFTCPRSDGRRAMEILKKLQVQGNWTNVLYDDQVGKVSLVGAGMKPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQL 3ab4 I 2.47 BS01 THR I 1 D274 K275 A279 Q298 D232 K233 A237 Q256 2.7.2.4 0004072,0005524,0005829,0008652,0009085,0009088,0009089,0009090,0016301,0016310,0019877 P26512 20573952 501 ALVVQKYGGSSLESAERIRNVAERIVATKKAGNDVVVVCSAMGDTTDELLELAAAVNPVPPAREMDMLLTAGERISNALVAMAIESLGAEAQSFTPGRVREALDEGKICIVAGSDTTAVALAAALNADVCEIYSDVDGVYTADPRIVPNAQKLEKLSFEEMLELAAVGSKILVLRSVEYARAFNVPLRVRSSYSNDPGTLIAGSMEDIPVAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVFSTTDITFTCPRSDGRRAMEILKKLQVQGNWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQ 3ab4 I 2.47 BS02 THR J 1 N374 I375 N328 I329 2.7.2.4 0004072,0005524,0005829,0008652,0009085,0009088,0009089,0009090,0016301,0016310,0019877 P26512 20573952 201 ALVVQKYGGSSLESAERIRNVAERIVATKKAGNDVVVVCSAMGDTTDELLELAAAVNPVPPAREMDMLLTAGERISNALVAMAIESLGAEAQSFTPGRVREALDEGKICIVAGSDTTAVALAAALNADVCEIYSDVDGVYTADPRIVPNAQKLEKLSFEEMLELAAVGSKILVLRSVEYARAFNVPLRVRSSYSNDPGTLIAGSMEDIPVAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVFSTTDITFTCPRSDGRRAMEILKKLQVQGNWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQ 3ab4 J 2.47 BS01 THR I 1 N125 I126 N104 I105 2.7.2.4 P26512 20573952 501 VATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVFSTTDITFTCPRSDGRRAMEILKKLQVQWTNVLYDDQVGKVSLVGGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALH 3ab4 J 2.47 BS02 THR J 1 K26 E29 A30 Q49 K18 E21 A22 Q41 2.7.2.4 P26512 20573952 201 VATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVFSTTDITFTCPRSDGRRAMEILKKLQVQWTNVLYDDQVGKVSLVGGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALH 3ab4 K 2.47 BS01 THR K 1 D274 K275 E278 A279 Q298 D243 K244 E247 A248 Q267 2.7.2.4 0004072,0005524,0005829,0008652,0009085,0009088,0009089,0009090,0016301,0016310,0019877 P26512 20573952 501 ALVVQKYGGSSLESAERIRNVAERIVATKKAGNDVVVVCSAMGDTTDELLELAAAVNPVPPAREMDMLLTAGERISNALVAMAIESLGAEAQSFTGRVREALDEGKICIVATRDVTTLGRGGSDTTAVALAAALNADVCEIYSDVDGVYTADPRIVPNAQKLEKLSFEEMLELAAVGSKILVLRSVEYARAFNVPLRVRSSYSNDPGTLIAGSMEDIPVEEAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVFGTTDITFTCPRSDGRRAMEILKKLQVQGNWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQLG 3ab4 K 2.47 BS03 THR L 1 N374 I375 N339 I340 2.7.2.4 0004072,0005524,0005829,0008652,0009085,0009088,0009089,0009090,0016301,0016310,0019877 P26512 20573952 201 ALVVQKYGGSSLESAERIRNVAERIVATKKAGNDVVVVCSAMGDTTDELLELAAAVNPVPPAREMDMLLTAGERISNALVAMAIESLGAEAQSFTGRVREALDEGKICIVATRDVTTLGRGGSDTTAVALAAALNADVCEIYSDVDGVYTADPRIVPNAQKLEKLSFEEMLELAAVGSKILVLRSVEYARAFNVPLRVRSSYSNDPGTLIAGSMEDIPVEEAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVFGTTDITFTCPRSDGRRAMEILKKLQVQGNWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQLG 3ab4 L 2.47 BS01 THR K 1 N125 I126 N122 I123 2.7.2.4 P26512 20573952 501 EEAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVFSVEDGTTDITFTCPRSDGRRAMEILKKLQVNWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQLG 3ab4 L 2.47 BS03 THR L 1 D25 K26 A30 Q49 D24 K25 A29 Q48 2.7.2.4 P26512 20573952 201 EEAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVFSVEDGTTDITFTCPRSDGRRAMEILKKLQVNWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQLG 3ab4 M 2.47 BS01 THR M 1 K275 A279 Q298 K248 A252 Q271 2.7.2.4 0004072,0005524,0005829,0008652,0009085,0009088,0009089,0009090,0016301,0016310,0019877 P26512 20573952 501 ALVVQKYGGSSLESAERIRNVAERIVATKKAGNDVVVVCSAMGDTTDELLELAAAVNPVPPAREMDMLLTAGERISNALVAMAIESLGAEAQSFTGDVTPGRVREALDEGKICIVAGFVTTLGRGGSDTTAVALAAALNADVCEIYSDVDGVYTADPRIVPNAQKLEKLSFEEMLELAAVGSKILVLRSVEYARAFNVPLRVRSSYSNDPGTLIAGSMEDIPVEEAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVFGTTDITFTCPRSDGRRAMEILKKLQVQGNWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQLG 3ab4 M 2.47 BS03 THR N 1 N374 I375 N343 I344 2.7.2.4 0004072,0005524,0005829,0008652,0009085,0009088,0009089,0009090,0016301,0016310,0019877 P26512 20573952 201 ALVVQKYGGSSLESAERIRNVAERIVATKKAGNDVVVVCSAMGDTTDELLELAAAVNPVPPAREMDMLLTAGERISNALVAMAIESLGAEAQSFTGDVTPGRVREALDEGKICIVAGFVTTLGRGGSDTTAVALAAALNADVCEIYSDVDGVYTADPRIVPNAQKLEKLSFEEMLELAAVGSKILVLRSVEYARAFNVPLRVRSSYSNDPGTLIAGSMEDIPVEEAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVFGTTDITFTCPRSDGRRAMEILKKLQVQGNWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQLG 3ab4 N 2.47 BS01 THR M 1 N125 I126 N122 I123 2.7.2.4 P26512 20573952 501 AVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVFSVEDGTTDITFTCPRSDGRRAMEILKKLQVQGNWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQL 3ab4 N 2.47 BS03 THR N 1 K26 G28 E29 A30 Q49 K23 G25 E26 A27 Q46 2.7.2.4 P26512 20573952 201 AVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVFSVEDGTTDITFTCPRSDGRRAMEILKKLQVQGNWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQL 3ab4 O 2.47 BS01 THR O 1 K275 G277 E278 A279 Q298 K240 G242 E243 A244 Q263 2.7.2.4 0004072,0005524,0005829,0008652,0009085,0009088,0009089,0009090,0016301,0016310,0019877 P26512 20573952 501 ALVVQKYGGSSLESAERIRNVAERIVATKKAGNDVVVVCSAMGDTTDELLELAAAVNPVPPAREMDMLLTAGERISNALVAMAIESLGAEAQSFTDVTPGRVREALDEGKICIVARGGSDTTAVALAAALNADVCEIYSDVDGVYTADPRIVPNAQKLEKLSFEEMLELAAVGSKILVLRSVEYARAFNVPLRVRSSYSNDPGTLIAGSMEDIPVEEAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNDGTTDITFTCPRSDGRRAMEILKKQGNWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQL 3ab4 O 2.47 BS03 THR P 1 N374 I375 N331 I332 2.7.2.4 0004072,0005524,0005829,0008652,0009085,0009088,0009089,0009090,0016301,0016310,0019877 P26512 20573952 201 ALVVQKYGGSSLESAERIRNVAERIVATKKAGNDVVVVCSAMGDTTDELLELAAAVNPVPPAREMDMLLTAGERISNALVAMAIESLGAEAQSFTDVTPGRVREALDEGKICIVARGGSDTTAVALAAALNADVCEIYSDVDGVYTADPRIVPNAQKLEKLSFEEMLELAAVGSKILVLRSVEYARAFNVPLRVRSSYSNDPGTLIAGSMEDIPVEEAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNDGTTDITFTCPRSDGRRAMEILKKQGNWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQL 3ab4 P 2.47 BS01 THR O 1 N125 I126 N117 I118 2.7.2.4 P26512 20573952 501 VLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVFSVEDGTTDITFTCPRSDGRRAMEILKKLQVQGNWTNVLYDDQVGKVSLVGAHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQ 3ab4 P 2.47 BS03 THR P 1 K26 G28 E29 A30 Q49 K22 G24 E25 A26 Q45 2.7.2.4 P26512 20573952 201 VLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVFSVEDGTTDITFTCPRSDGRRAMEILKKLQVQGNWTNVLYDDQVGKVSLVGAHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQ 3aje A 1.8 BS01 THR A 1 T36 V37 G39 H68 R122 A142 E181 S182 T35 V36 G38 H67 R121 A141 E180 S181 2.7.7.87 0000049,0003725,0005524,0005737,0006450,0008033,0016779,0061710 -logKd/Ki=5.03, Kd=9.3uM Q970S6 21538543 353 TQIIKIDPLNPEIDKIKIAADVIRNGGTVAFPTETVYGLGANAFDGNACLKIFQAKNRPVDNPLIVHIADFNQLFEVAKDIPDKVLEIAQIVWPGPLTFVLKKTERVPKEVTAGLDTVAVRMPAHPIALQLIRESGVPIAAPSANLATRPSPTKAEDVIVDLNGRVDVIIDGGHTFFGVESTIINVTVEPPVLLRPGPFTIEELKKLFGEIVIPHYAPNTRLLLVENRNIFKDVVSLLSKKYKVALLIPKELSKEFEGLQQIILGSDENLYEVARNLFDSFRELDKLNVDLGIMIGFPERGIGFAIMNRARKASGFSIIKAISDVYKYV 3c1n A 2.72 BS01 THR A 1 A417 I420 A421 Q440 E444 A406 I409 A410 Q429 E433 2.7.2.4 0003824,0004072,0005524,0005829,0008652,0009088,0009089,0009090,0016301,0016310 Q57991 18334478 471 TTVMKFGGTSVGSGERIRHVAKIVTKRKKEDDDVVVVVSAMSEVTNALVEISQQALDVRDIAKVGDFIKFIREKHYKAIEEAISEEIKEEVKKIIDSRIEELEKVLIGVAYLGELTPKSRDYILSFGERLSSPILSGAIRDLGEKSIALEGGEAGIITDNNFGSARVKRLEVKERLLPLLKEGIIPVVTGFIGTTEEGYITTLGRGGSDYSAALIGYGLDADIIEIWTDVSGVYTTDPRLVPTARRIPKLSYIEAMELAYFGAKVLHPRTIEPAMEKGIPILVKNTFEPESEGTLITNDMDSIVKAISTIKNVALINIFGAGMVGVSGTAARIFKALGEEEVNVILISQGSSETNISLVVSEEDVDKALKALKREFGDLNNNLIRDVSVDKDVCVISVVGAGMRGAKGIAGKIFTAVSESGANIKMIAQGSSEVNISFVIDEKDLLNCVRKLHEKFIE 3c1n A 2.72 BS02 THR A 2 G8 G9 T10 S11 W229 T230 D231 G7 G8 T9 S10 W227 T228 D229 2.7.2.4 0003824,0004072,0005524,0005829,0008652,0009088,0009089,0009090,0016301,0016310 Q57991 18334478 473 TTVMKFGGTSVGSGERIRHVAKIVTKRKKEDDDVVVVVSAMSEVTNALVEISQQALDVRDIAKVGDFIKFIREKHYKAIEEAISEEIKEEVKKIIDSRIEELEKVLIGVAYLGELTPKSRDYILSFGERLSSPILSGAIRDLGEKSIALEGGEAGIITDNNFGSARVKRLEVKERLLPLLKEGIIPVVTGFIGTTEEGYITTLGRGGSDYSAALIGYGLDADIIEIWTDVSGVYTTDPRLVPTARRIPKLSYIEAMELAYFGAKVLHPRTIEPAMEKGIPILVKNTFEPESEGTLITNDMDSIVKAISTIKNVALINIFGAGMVGVSGTAARIFKALGEEEVNVILISQGSSETNISLVVSEEDVDKALKALKREFGDLNNNLIRDVSVDKDVCVISVVGAGMRGAKGIAGKIFTAVSESGANIKMIAQGSSEVNISFVIDEKDLLNCVRKLHEKFIE 3c1n A 2.72 BS03 THR B 1 N434 I435 N423 I424 2.7.2.4 0003824,0004072,0005524,0005829,0008652,0009088,0009089,0009090,0016301,0016310 Q57991 18334478 470 TTVMKFGGTSVGSGERIRHVAKIVTKRKKEDDDVVVVVSAMSEVTNALVEISQQALDVRDIAKVGDFIKFIREKHYKAIEEAISEEIKEEVKKIIDSRIEELEKVLIGVAYLGELTPKSRDYILSFGERLSSPILSGAIRDLGEKSIALEGGEAGIITDNNFGSARVKRLEVKERLLPLLKEGIIPVVTGFIGTTEEGYITTLGRGGSDYSAALIGYGLDADIIEIWTDVSGVYTTDPRLVPTARRIPKLSYIEAMELAYFGAKVLHPRTIEPAMEKGIPILVKNTFEPESEGTLITNDMDSIVKAISTIKNVALINIFGAGMVGVSGTAARIFKALGEEEVNVILISQGSSETNISLVVSEEDVDKALKALKREFGDLNNNLIRDVSVDKDVCVISVVGAGMRGAKGIAGKIFTAVSESGANIKMIAQGSSEVNISFVIDEKDLLNCVRKLHEKFIE 3c1n B 2.72 BS01 THR A 1 N434 I435 N424 I425 2.7.2.4 0003824,0004072,0005524,0005829,0008652,0009088,0009089,0009090,0016301,0016310 Q57991 18334478 471 TTVMKFGGTSVGSGERIRHVAKIVTKRKKEDDDVVVVVSAMSEVTNALVEISQQALDVRDIAKVGDFIKFIREKHYKAIEEAIKSEEIKEEVKKIIDSRIEELEKVLIGVAYLGELTPKSRDYILSFGERLSSPILSGAIRDLGEKSIALEGGEAGIITDNNFGSARVKRLEVKERLLPLLKEGIIPVVTGFIGTTEEGYITTLGRGGSDYSAALIGYGLDADIIEIWTDVSGVYTTDPRLVPTARRIPKLSYIEAMELAYFGAKVLHPRTIEPAMEKGIPILVKNTFEPESEGTLITNDSDSIVKAISTIKNVALINIFGAGMVGVSGTAARIFKALGEEEVNVILISQGSSETNISLVVSEEDVDKALKALKREFGDLNNNLIRDVSVDKDVCVISVVGAGMRGAKGIAGKIFTAVSESGANIKMIAQGSSEVNISFVIDEKDLLNCVRKLHEKFIE 3c1n B 2.72 BS02 THR B 1 A417 K418 I420 A421 Q440 E444 A407 K408 I410 A411 Q430 E434 2.7.2.4 0003824,0004072,0005524,0005829,0008652,0009088,0009089,0009090,0016301,0016310 Q57991 18334478 470 TTVMKFGGTSVGSGERIRHVAKIVTKRKKEDDDVVVVVSAMSEVTNALVEISQQALDVRDIAKVGDFIKFIREKHYKAIEEAIKSEEIKEEVKKIIDSRIEELEKVLIGVAYLGELTPKSRDYILSFGERLSSPILSGAIRDLGEKSIALEGGEAGIITDNNFGSARVKRLEVKERLLPLLKEGIIPVVTGFIGTTEEGYITTLGRGGSDYSAALIGYGLDADIIEIWTDVSGVYTTDPRLVPTARRIPKLSYIEAMELAYFGAKVLHPRTIEPAMEKGIPILVKNTFEPESEGTLITNDSDSIVKAISTIKNVALINIFGAGMVGVSGTAARIFKALGEEEVNVILISQGSSETNISLVVSEEDVDKALKALKREFGDLNNNLIRDVSVDKDVCVISVVGAGMRGAKGIAGKIFTAVSESGANIKMIAQGSSEVNISFVIDEKDLLNCVRKLHEKFIE 3c1n B 2.72 BS03 THR B 2 G8 T10 S11 W229 T230 D231 G7 T9 S10 W228 T229 D230 2.7.2.4 0003824,0004072,0005524,0005829,0008652,0009088,0009089,0009090,0016301,0016310 Q57991 18334478 474 TTVMKFGGTSVGSGERIRHVAKIVTKRKKEDDDVVVVVSAMSEVTNALVEISQQALDVRDIAKVGDFIKFIREKHYKAIEEAIKSEEIKEEVKKIIDSRIEELEKVLIGVAYLGELTPKSRDYILSFGERLSSPILSGAIRDLGEKSIALEGGEAGIITDNNFGSARVKRLEVKERLLPLLKEGIIPVVTGFIGTTEEGYITTLGRGGSDYSAALIGYGLDADIIEIWTDVSGVYTTDPRLVPTARRIPKLSYIEAMELAYFGAKVLHPRTIEPAMEKGIPILVKNTFEPESEGTLITNDSDSIVKAISTIKNVALINIFGAGMVGVSGTAARIFKALGEEEVNVILISQGSSETNISLVVSEEDVDKALKALKREFGDLNNNLIRDVSVDKDVCVISVVGAGMRGAKGIAGKIFTAVSESGANIKMIAQGSSEVNISFVIDEKDLLNCVRKLHEKFIE 3c1n C 2.72 BS01 THR C 1 G8 T10 S11 T230 D231 K266 G7 T9 S10 T229 D230 K265 2.7.2.4 0003824,0004072,0005524,0005829,0008652,0009088,0009089,0009090,0016301,0016310 Q57991 18334478 475 TTVMKFGGTSVGSGERIRHVAKIVTKRKKEDDDVVVVVSAMSEVTNALVEISQQALDVRDIAKVGDFIKFIREKHYKAIEEAIKSEEIKEEVKKIIDSRIEELEKVLIGVAYLGELTPKSRDYILSFGERLSSPILSGAIRDLGEKSIALEGGEAGIITDNNFGSARVKRLEVKERLLPLLKEGIIPVVTGFIGTTEEGYITTLGRGGSDYSAALIGYGLDADIIEIWTDVSGVYTTDPRLVPTARRIPKLSYIEAMELAYFGAKVLHPRTIEPAMEKGIPILVKNTFEPESEGTLITNDMSIVKAISTIKNVALINIFGAGMVGVSGTAARIFKALGEEEVNVILISQGSSETNISLVVSEEDVDKALKALKREFLNNNLIRDVSVDKDVCVISVVGAGMRGAKGIAGKIFTAVSESGANIKMIAQGSSEVNISFVIDEKDLLNCVRKLHEKFIE 3c1n C 2.72 BS02 THR D 1 N434 I435 N421 I422 2.7.2.4 0003824,0004072,0005524,0005829,0008652,0009088,0009089,0009090,0016301,0016310 Q57991 18334478 472 TTVMKFGGTSVGSGERIRHVAKIVTKRKKEDDDVVVVVSAMSEVTNALVEISQQALDVRDIAKVGDFIKFIREKHYKAIEEAIKSEEIKEEVKKIIDSRIEELEKVLIGVAYLGELTPKSRDYILSFGERLSSPILSGAIRDLGEKSIALEGGEAGIITDNNFGSARVKRLEVKERLLPLLKEGIIPVVTGFIGTTEEGYITTLGRGGSDYSAALIGYGLDADIIEIWTDVSGVYTTDPRLVPTARRIPKLSYIEAMELAYFGAKVLHPRTIEPAMEKGIPILVKNTFEPESEGTLITNDMSIVKAISTIKNVALINIFGAGMVGVSGTAARIFKALGEEEVNVILISQGSSETNISLVVSEEDVDKALKALKREFLNNNLIRDVSVDKDVCVISVVGAGMRGAKGIAGKIFTAVSESGANIKMIAQGSSEVNISFVIDEKDLLNCVRKLHEKFIE 3c1n D 2.72 BS01 THR D 1 M414 A417 K418 I420 A421 E444 M397 A400 K401 I403 A404 E427 2.7.2.4 0003824,0004072,0005524,0005829,0008652,0009088,0009089,0009090,0016301,0016310 Q57991 18334478 472 TVMKFGGTSVGSGERIRHVAKIVTKRKKEDVVVVSAMSEVTNALVEISQQALDVRDIAKVGDFIKFIREKHYKAIEEAISEEIKEEVKKIIDSRIEELEKVLIGVAYLGELTPKSRDYILSFGERLSSPILSGAIRDLGEKSIALEGGEAGIITDNNFGSARVKRLEVKERLLPLLKEGIIPVVTGFIGTTEEGYITTLGRGGSDYSAALIGYGLDADIIEIWTDVSGVYTTDPRLVPTARRIPKLSYIEAMELAYFGAKVLHPRTIEPAMEKGIPILVKNTFEPESEGTLITNDSIVKAISTIKNVALINIFGAGMVGVSGTAARIFKALGEEEVNVILISQGSSETNISLVVSEEDVDKALKALKREFGDLNNNLIRDVSVDKDVCVISVVGAGMRGAKGIAGKIFTAVSESGANIKMIAQGSSEVNISFVIDEKDLLNCVRKLHEKFIE 3c1n D 2.72 BS02 THR D 2 K6 G8 T10 S11 W229 T230 D231 K4 G6 T8 S9 W223 T224 D225 2.7.2.4 0003824,0004072,0005524,0005829,0008652,0009088,0009089,0009090,0016301,0016310 Q57991 18334478 476 TVMKFGGTSVGSGERIRHVAKIVTKRKKEDVVVVSAMSEVTNALVEISQQALDVRDIAKVGDFIKFIREKHYKAIEEAISEEIKEEVKKIIDSRIEELEKVLIGVAYLGELTPKSRDYILSFGERLSSPILSGAIRDLGEKSIALEGGEAGIITDNNFGSARVKRLEVKERLLPLLKEGIIPVVTGFIGTTEEGYITTLGRGGSDYSAALIGYGLDADIIEIWTDVSGVYTTDPRLVPTARRIPKLSYIEAMELAYFGAKVLHPRTIEPAMEKGIPILVKNTFEPESEGTLITNDSIVKAISTIKNVALINIFGAGMVGVSGTAARIFKALGEEEVNVILISQGSSETNISLVVSEEDVDKALKALKREFGDLNNNLIRDVSVDKDVCVISVVGAGMRGAKGIAGKIFTAVSESGANIKMIAQGSSEVNISFVIDEKDLLNCVRKLHEKFIE 3l76 A 2.54 BS01 THR A 1 R281 V284 A285 Q304 N557 I558 R269 V272 A273 Q292 N542 I543 2.7.2.4 0004072,0005524,0005829,0008652,0009085,0009088,0009089,0009090,0016301,0016310 P74569 20398676 601 ALIVQKFGGTSVGTVERIQAVAQRIKRTVQGGNSLVVVVSAMGKSTDVLVDLAQQISPNPCRREMDMLLSTGEQVSIALLSLALQEIDQPAISLTGAQVGIVTEILEIRPDRLEHHLREGKVVVVAGFQGIHLEITTLGRGGSDTSAVALAAALKADFCEIYTDVPGILTTDPRLVPEAQLMAEITCDEMLELASLGAKVLHPRAVEIARNYGIPLVVRSSWSDEPGTKVVAPPVQNRSLVGLEIAKAVDGVEYDADQAKVALLRVPDRPGVASKLFRDIAQQQVDIDLIIQSIHDGNSNDIAFTVVKDLLNTAEAVTSAIAPALRSYPEADQEAEIIVEKGIAKIAIAGAGMIGRPGIAAKMFKTLADVGVNIEMISTSEVKVSCVIDQRDADRAIAALSNAFGVTLSPPKNQTDLPAVRGVALDQDQAQIAIRHVPDRPGMAAQLFTALAEANISVDMIIQSQRCRINQGTPCRDIAFMVAEGDSSQAEAILQPLIKDWLDAAIVVNKAIAKVSIVGSGMIGHPGVAAHFFAALAQENINIEMIATSEIKISCVVPQDRGVDALKAAHSAFNLAGTKTVTVPA 3l76 A 2.54 BS02 THR A 2 N385 I386 R455 M458 Q478 N373 I374 R440 M443 Q463 2.7.2.4 0004072,0005524,0005829,0008652,0009085,0009088,0009089,0009090,0016301,0016310 P74569 20398676 602 ALIVQKFGGTSVGTVERIQAVAQRIKRTVQGGNSLVVVVSAMGKSTDVLVDLAQQISPNPCRREMDMLLSTGEQVSIALLSLALQEIDQPAISLTGAQVGIVTEILEIRPDRLEHHLREGKVVVVAGFQGIHLEITTLGRGGSDTSAVALAAALKADFCEIYTDVPGILTTDPRLVPEAQLMAEITCDEMLELASLGAKVLHPRAVEIARNYGIPLVVRSSWSDEPGTKVVAPPVQNRSLVGLEIAKAVDGVEYDADQAKVALLRVPDRPGVASKLFRDIAQQQVDIDLIIQSIHDGNSNDIAFTVVKDLLNTAEAVTSAIAPALRSYPEADQEAEIIVEKGIAKIAIAGAGMIGRPGIAAKMFKTLADVGVNIEMISTSEVKVSCVIDQRDADRAIAALSNAFGVTLSPPKNQTDLPAVRGVALDQDQAQIAIRHVPDRPGMAAQLFTALAEANISVDMIIQSQRCRINQGTPCRDIAFMVAEGDSSQAEAILQPLIKDWLDAAIVVNKAIAKVSIVGSGMIGHPGVAAHFFAALAQENINIEMIATSEIKISCVVPQDRGVDALKAAHSAFNLAGTKTVTVPA 3l76 B 2.54 BS01 THR B 1 N385 I386 D454 R455 M458 A459 Q478 N372 I373 D435 R436 M439 A440 Q459 2.7.2.4 0004072,0005524,0005829,0008652,0009085,0009088,0009089,0009090,0016301,0016310 P74569 20398676 601 ALIVQKFGGTSVGTVERIQAVAQRIKRTVQGGNSLVVVVSAMGKSTDVLVDLAQQISPNPCRREMDMLLSTGEQVSIALLSLALQEIDQPAISLTGAQVGIVTELEIRPDRLEHHLREGKVVVVAGFQGISEHLEITTLGRGGSDTSAVALAAALKADFCEIYTDVPGILTTDPRLVPEAQLMAEITCDEMLELASLGAKVLHPRAVEIARNYGIPLVVRSSWSDEPGTKVVAPPVRSLVGLEIAKAVDGVEYDADQAKVALLRVPDRPGVASKLFRDIAQQQVDIDLIIQSIHDGNSNDIAFTVVKDLLNTAEAVTSAIAPALRSYPEADQEAEIIVEKGIAKIAIAGAGMIGRPGIAAKMFKTLADVGVNIEMISTSEVKVSCVIDQRDADRAIAALSNAFGVTLSPPKNLPAVRGVALDQDQAQIAIRHVPDRPGMAAQLFTALAEANISVDMIIQSQRCRINQGTPCRDIAFMVAEGDSSQAEAILQPLIKDWLDAAIVVNKAIAKVSIVGSGMIGHPGVAAHFFAALAQENINIEMIATSEIKISCVVPQDRGVDALKAAHSAFNLAGTKTVTVPA 3l76 B 2.54 BS02 THR B 2 R281 V284 A285 Q304 N557 I558 R268 V271 A272 Q291 N538 I539 2.7.2.4 0004072,0005524,0005829,0008652,0009085,0009088,0009089,0009090,0016301,0016310 P74569 20398676 602 ALIVQKFGGTSVGTVERIQAVAQRIKRTVQGGNSLVVVVSAMGKSTDVLVDLAQQISPNPCRREMDMLLSTGEQVSIALLSLALQEIDQPAISLTGAQVGIVTELEIRPDRLEHHLREGKVVVVAGFQGISEHLEITTLGRGGSDTSAVALAAALKADFCEIYTDVPGILTTDPRLVPEAQLMAEITCDEMLELASLGAKVLHPRAVEIARNYGIPLVVRSSWSDEPGTKVVAPPVRSLVGLEIAKAVDGVEYDADQAKVALLRVPDRPGVASKLFRDIAQQQVDIDLIIQSIHDGNSNDIAFTVVKDLLNTAEAVTSAIAPALRSYPEADQEAEIIVEKGIAKIAIAGAGMIGRPGIAAKMFKTLADVGVNIEMISTSEVKVSCVIDQRDADRAIAALSNAFGVTLSPPKNLPAVRGVALDQDQAQIAIRHVPDRPGMAAQLFTALAEANISVDMIIQSQRCRINQGTPCRDIAFMVAEGDSSQAEAILQPLIKDWLDAAIVVNKAIAKVSIVGSGMIGHPGVAAHFFAALAQENINIEMIATSEIKISCVVPQDRGVDALKAAHSAFNLAGTKTVTVPA 3s1t A 1.63 BS01 THR A 1 D25 I26 Y29 A30 Q49 D23 I24 Y27 A28 Q47 2.7.2.4 P9WPX3 301 DPILTGVAHDRSEAKVTIVGLPDIPGYAAKVFRAVADADVNIDMVLQNVSKVEDGKTDITFTCSRDVGPAAVEKLDSLRNEIGFSQLLYDDHIGKVSLIGAGMRSHPGVTATFCEALAAVGVNIELISTSEIRISVLCRDTELDKAVVALHEAFGLGG 3s1t A 1.63 BS02 THR B 1 N125 I126 N123 I124 2.7.2.4 P9WPX3 302 DPILTGVAHDRSEAKVTIVGLPDIPGYAAKVFRAVADADVNIDMVLQNVSKVEDGKTDITFTCSRDVGPAAVEKLDSLRNEIGFSQLLYDDHIGKVSLIGAGMRSHPGVTATFCEALAAVGVNIELISTSEIRISVLCRDTELDKAVVALHEAFGLGG 3s1t B 1.63 BS01 THR A 1 N125 I126 N123 I124 2.7.2.4 P9WPX3 301 DPILTGVAHDRSEAKVTIVGLPDIPGYAAKVFRAVADADVNIDMVLQNVSKVEDGKTDITFTCSRDVGPAAVEKLDSLRNEIGFSQLLYDDHIGKVSLIGAGMRSHPGVTATFCEALAAVGVNIELISTSEIRISVLCRDTELDKAVVALHEAFGL 3s1t B 1.63 BS02 THR B 1 I26 Y29 A30 Q49 I24 Y27 A28 Q47 2.7.2.4 P9WPX3 302 DPILTGVAHDRSEAKVTIVGLPDIPGYAAKVFRAVADADVNIDMVLQNVSKVEDGKTDITFTCSRDVGPAAVEKLDSLRNEIGFSQLLYDDHIGKVSLIGAGMRSHPGVTATFCEALAAVGVNIELISTSEIRISVLCRDTELDKAVVALHEAFGL 3wmx A 2.5 BS02 THR A 1 L80 S81 Y144 G184 T186 W280 L77 S78 Y141 G181 T183 W277 5.3.-.- 0000166,0006567,0008743,0016853,0046872 Q0K312 24558034 402 GKPKILIVGANGQIGSELALALAERYGRTNVITSDVVPTGRHVHLTHEMLNATDRGELATVVERHGITQVYLLAAALSATGEKAPQWAWNLNMTSLLNVLELARQTGLERVFWPSSIAAFGPTTPAGQTPQKTVMEPTTVYGISKQAGEGWCRWYHANHGVDVRSVRYPGLISHKTPPGGGTTDYAVDIFHAAVTGEPYTCFLKEDEALPMMYMPDAIRATIELMEAPADKLSERGSYNIAGMSFTPAQIAAAIREQVPGFQIRYEPDYRQAIAQGWPDSIDDSVARADWGWKAQYGLKEMVADMLANLK 3wmx B 2.5 BS02 THR B 1 L80 S81 Y144 G184 T185 T186 L75 S76 Y139 G179 T180 T181 5.3.-.- 0000166,0006567,0008743,0016853,0046872 Q0K312 24558034 402 PKILIVGANGQIGSELALALAERYGRTNVITSDVVPTGRHVHLTHEMLNATDRGELATVVERHGITQVYLLAAALSATGEKAPQWAWNLNMTSLLNVLELARQTGLERVFWPSSIAAFGPTTPAGQTPQKTVMEPTTVYGISKQAGEGWCRWYHANHGVDVRSVRYPGLISHKTPPGGGTTDYAVDIFHAAVTGEPYTCFLKEDEALPMMYMPDAIRATIELMEAPADKLSERGSYNIAGMSFTPAQIAAAIREQVPGFQIRYEPDYRQAIAQGWPDSIDDSVARADWGWKAQYGLKEMVADMLANLK 3zsw A 1.8 BS01 THR A 1 D207 I208 Q209 D147 I148 Q149 2.7.7.-,2.7.7.49,2.7.7.7,3.1.-.-,3.1.13.2,3.1.26.13,3.4.23.16 0003676,0015074 P12497 22808106 301 SPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSNFTSTTVKAACWWAGIKQEDGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNHKRKGYSAGERIVDIIATDIQ 3zsw B 1.8 BS02 THR B 1 D207 I208 Q209 D147 I148 Q149 2.7.7.-,2.7.7.49,2.7.7.7,3.1.-.-,3.1.13.2,3.1.26.13,3.4.23.16 0003676,0015074 P12497 22808106 301 SPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSNFTSTTVKAACWWAGIKQEDGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNHKRKGYSAGERIVDIIATDIQ 4ger A 1.59 BS05 THR A 1 E136 R191 E136 R191 H135 E136 H139 Y150 E159 D214 H219 H135 E136 H139 Y150 E159 D214 H219 3.4.24.28 0004222,0006508 P29148 23275160 405 ATGTGKGVLGDTKSFTTTASGSSYQLKDTTRGNGVVTYTASNRQSIPGTILTDADNVWNDPAGVDAHTYAAKTYDYYKAKFGRNSIDGRGLQLRSTVHYGSRYNNAFWNGSQMTYGDGDGSTFIAFSGDPDVVGHELTHGVTEYTSNLEYYGESGALNEAFSDVIGNDIQRKNWLVGDDIYTPNIAGDALRSMSNPTLYDQPDHYSNLYTGSSDNGGVHTNSGIINKAYYLLAQGGTFHGVTVNGIGRDAAVQIYYSAFTNYLTSSSDFSNARAAVIQAAKDQYGANSAEATAAAKSFDAVGVN 4ger B 1.59 BS05 THR B 1 F126 E136 R191 F126 E136 R191 H135 E136 H139 Y150 E159 D214 H219 H135 E136 H139 Y150 E159 D214 H219 3.4.24.28 0004222,0006508 P29148 23275160 405 ATGTGKGVLGDTKSFTTTASGSSYQLKDTTRGNGVVTYTASNRQSIPGTILTDADNVWNDPAGVDAHTYAAKTYDYYKAKFGRNSIDGRGLQLRSTVHYGSRYNNAFWNGSQMTYGDGDGSTFIAFSGDPDVVGHELTHGVTEYTSNLEYYGESGALNEAFSDVIGNDIQRKNWLVGDDIYTPNIAGDALRSMSNPTLYDQPDHYSNLYTGSSDNGGVHTNSGIINKAYYLLAQGGTFHGVTVNGIGRDAAVQIYYSAFTNYLTSSSDFSNARAAVIQAAKDQYGANSAEATAAAKSFDAVGVN 4go7 X 2.0 BS01 THR X 1 I26 G28 Y29 A30 Q49 I29 G31 Y32 A33 Q52 2.7.2.4 P9WPX3 21976064 201 SIHMEDPILTGVAHDRSEAKVTIVGLPDIPGYAAKVFRAVADADVNIDMVLQNVSKDGKTDITFTCSRDVGPAAVEKLDSLRNEIGFSQLLYDDHIGKVSLIGAGMRSHPGVTATFCEALAAVGVNIELISTSEIRISVLCRDTELDKAVVALHEAFGLEATVYA 4qfp A 1.903 BS02 THR A 1 G50 R383 Y385 G22 R355 Y357 ? 0015833,0030288,0043190,0055085,1904680 -logKd/Ki=4.23, Kd=58.6uM A7Y7W1 25605306 602 QGLVYCAEANPVSFNPQVTTTGSTIDIIANQLYDRLISIDPVTAEFKSELATDWKISKDGKSVTFTLRKGVKFHTTAYFTPTREFNADDVIFTFSRLFDVYNPYHFVGDANYPYFQSVGIDQLIRKIVRVSDHQVRFELFNAESSFLANMATDFAVVLSKEYAMALKANNQENLFDQYPVGTGPYIYKEYRRDHLVRFYKNADYWKHEVALEQLVYDITPNGTTRIAKILTKECDVTAHPSSAQLSILAQRDDINVERETNLNIGYWAFNTERPPFDNLKVRQALVHAIDIEKIMQAVYYGNGLRARSILPPTSWAFEPQKNMPIFDPQLAKKLLTEAGYEKGFDMSIWAMPVSRIYNPNARKMAELMQSDLRKIGVNVNIVEYEWNTFIQRIGEHRHDSVLLGWAADTPDPDNFFSPLLSCTATFSGKNPANWCNPEFDLLLTKALDTTDLNLRKQYYDAAQSMIIEQLPLYPIAHGMRFQASSADVEGITLGPFGAISLANARKK 4qfp B 1.903 BS02 THR B 1 T48 G50 R383 Y385 T20 G22 R355 Y357 ? 0015833,0030288,0043190,0055085,1904680 A7Y7W1 25605306 602 QGLVYCAEANPVSFNPQVTTTGSTIDIIANQLYDRLISIDPVTAEFKSELATDWKISKDGKSVTFTLRKGVKFHTTAYFTPTREFNADDVIFTFSRLFDVYNPYHFVGDANYPYFQSVGIDQLIRKIVRVSDHQVRFELFNAESSFLANMATDFAVVLSKEYAMALKANNQENLFDQYPVGTGPYIYKEYRRDHLVRFYKNADYWKHEVALEQLVYDITPNGTTRIAKILTKECDVTAHPSSAQLSILAQRDDINVERETNLNIGYWAFNTERPPFDNLKVRQALVHAIDIEKIMQAVYYGNGLRARSILPPTSWAFEPQKNMPIFDPQLAKKLLTEAGYEKGFDMSIWAMPVSRIYNPNARKMAELMQSDLRKIGVNVNIVEYEWNTFIQRIGEHRHDSVLLGWAADTPDPDNFFSPLLSCTATFSGKNPANWCNPEFDLLLTKALDTTDLNLRKQYYDAAQSMIIEQLPLYPIAHGMRFQASSADVEGITLGPFGAISLANARKK 5ixj A 1.54 BS01 THR A 1 T105 G106 Q109 H110 D300 T105 G106 Q109 H110 D300 K82 E104 S371 K82 E104 S371 4.2.1.20 0000162,0004834,0005737,0006568,0016829 Q8U093 27355405 401 MWFGEFGGQYVPETLIEPLKELEKAYKRFKDDEEFNRQLNYYLKTWAGRPTPLYYAKRLTEKIGGAKIYLKREDLVHGGAHKTNNAIGQALLAKFMGKTRLIAETGAGQHGVATAMAGALLGMKVDIYMGAEDVERQKMNVFRMKLLGANVIPVNSGSRTLKDAINEALRDWVATFEYTHYLIGSVVGPHPYPTIVRDFQSVIGREAKAQILEAEGQLPDVIVACVGGGSNAMGIFYPFVNDKKVKLVGVEAGGKGLESGKHSASLNAGQVGVFHGMLSYFLQDEEGQIKPTHSIAPGLDYPGVGPEHAYLKKIQRAEYVTVTDEEALKAFHELSRTEGIIPALESAHAVAYAMKLAKEMSRDEIIIVNLSGRGDKDLDIVLKV 5ixj B 1.54 BS01 THR B 1 T105 G106 A107 Q109 G298 D300 T105 G106 A107 Q109 G295 D297 K82 E104 S371 K82 E104 S368 4.2.1.20 0000162,0004834,0005737,0006568,0016829 Q8U093 27355405 401 MWFGEFGGQYVPETLIEPLKELEKAYKRFKDDEEFNRQLNYYLKTWAGRPTPLYYAKRLTEKIGGAKIYLKREDLVHGGAHKTNNAIGQALLAKFMGKTRLIAETGAGQHGVATAMAGALLGMKVDIYMGAEDVERQKMNVFRMKLLGANVIPVNSGSRTLKDAINEALRDWVATFEYTHYLIGSVVGPHPYPTIVRDFQSVIGREAKAQILEAEGQLPDVIVACVGGGSNAMGIFYPFVNDKKVKLVGVEAGGKGLESGKHSASLNAGQVGVFHGMLSYFLQGQIKPTHSIAPGLDYPGVGPEHAYLKKIQRAEYVTVTDEEALKAFHELSRTEGIIPALESAHAVAYAMKLAKEMSRDEIIIVNLSGRGDKDLDIVLKVSGNVLEH 5ixj C 1.54 BS01 THR C 1 T105 G106 A107 Q109 H110 D300 T105 G106 A107 Q109 H110 D300 K82 E104 S371 K82 E104 S371 4.2.1.20 0000162,0004834,0005737,0006568,0016829 Q8U093 27355405 401 MWFGEFGGQYVPETLIEPLKELEKAYKRFKDDEEFNRQLNYYLKTWAGRPTPLYYAKRLTEKIGGAKIYLKREDLVHGGAHKTNNAIGQALLAKFMGKTRLIAETGAGQHGVATAMAGALLGMKVDIYMGAEDVERQKMNVFRMKLLGANVIPVNSGSRTLKDAINEALRDWVATFEYTHYLIGSVVGPHPYPTIVRDFQSVIGREAKAQILEAEGQLPDVIVACVGGGSNAMGIFYPFVNDKKVKLVGVEAGGKGLESGKHSASLNAGQVGVFHGMLSYFLQDEEGQIKPTHSIAPGLDYPGVGPEHAYLKKIQRAEYVTVTDEEALKAFHELSRTEGIIPALESAHAVAYAMKLAKEMSRDEIIIVNLSGRGDKDLDIVLKV 5ixj D 1.54 BS01 THR D 1 T105 G106 Q109 H110 D300 T105 G106 Q109 H110 D298 K82 E104 S371 K82 E104 S369 4.2.1.20 0000162,0004834,0005737,0006568,0016829 Q8U093 27355405 401 MWFGEFGGQYVPETLIEPLKELEKAYKRFKDDEEFNRQLNYYLKTWAGRPTPLYYAKRLTEKIGGAKIYLKREDLVHGGAHKTNNAIGQALLAKFMGKTRLIAETGAGQHGVATAMAGALLGMKVDIYMGAEDVERQKMNVFRMKLLGANVIPVNSGSRTLKDAINEALRDWVATFEYTHYLIGSVVGPHPYPTIVRDFQSVIGREAKAQILEAEGQLPDVIVACVGGGSNAMGIFYPFVNDKKVKLVGVEAGGKGLESGKHSASLNAGQVGVFHGMLSYFLQDGQIKPTHSIAPGLDYPGVGPEHAYLKKIQRAEYVTVTDEEALKAFHELSRTEGIIPALESAHAVAYAMKLAKEMSRDEIIIVNLSGRGDKDLDIVLKVSGNVLEHHHHHH 5k4w A 1.72 BS02 THR A 1 M1081 S1082 T1119 Y1144 G1184 A1185 T1186 W1280 M80 S81 T118 Y143 G183 A184 T185 W279 1.1.1.103 Q7YW97 30198897 1402 MPRVLVTGALGQIGTDLSLALRDKFGADSVLVSDVVEPGAKHPLAGLKGVEKLDCLDSNGFEKLVKEFKPTWMYHLPAIMSVRGEAEPDLAMDINVNTTRYALELARKYNIRIFIPSTIAAFGDKCGKTMTKDDTIMNPSTVYGVTKVYTELLGTWYRQKYGVDFRSVRLPGIISAATLPGGGATDYAIHMYHSALLQKKCVCPVLPYESLPMMYMPDTLNSLVKIMEAPLEKLTRTVYNITGFSFSPSELRFSIERCTDRTIEVEYVEGPAQKIANSWPDSLDDSNARNDWGHQVKYDIDMMSEDMLRQIPILHGLPSL 5k4w C 1.72 BS02 THR C 1 M1081 S1082 T1119 Y1144 G1184 A1185 T1186 W1280 M81 S82 T119 Y144 G184 A185 T186 W280 1.1.1.103 Q7YW97 30198897 1402 HMPRVLVTGALGQIGTDLSLALRDKFGADSVLVSDVVEPGAKHPLAGLKGVEKLDCLDSNGFEKLVKEFKPTWMYHLPAIMSVRGEAEPDLAMDINVNTTRYALELARKYNIRIFIPSTIAAFGDKCGKTMTKDDTIMNPSTVYGVTKVYTELLGTWYRQKYGVDFRSVRLPGIISAATLPGGGATDYAIHMYHSALLQKKCVCPVLPYESLPMMYMPDTLNSLVKIMEAPLEKLTRTVYNITGFSFSPSELRFSIERCTDRTIEVEYVEGPAQKIANSWPDSLDDSNARNDWGHQVKYDIDMMSEDMLRQIPILHGLPSL 5n9x A 2.396 BS01 THR A 1 F211 D212 F213 G285 G312 V318 K515 F186 D187 F188 G260 G287 V293 K475 T167 L187 T314 E315 K427 R432 K515 T142 L162 T289 E290 K395 R400 K475 ? 0003824,0005524,0005737,0031177,0043041,0044550 H6SG27 28704585 601 GATLVDLFSRAAMEMPDRTALHIDDEKISYGLLHSWAEGLADLLHDAGVRKGDRVALRMPPGANAIAAMLGILRAGAAYVPLDIRNPPARNAFIVTDSQVVALVGDPIPEYTGPLVTEENVAALRPGPERPGPQDVAYIIYTSGTTGRPKGVPVRHGNVTALFEACSRLFSFSADDRWLLFHSMAFDFSVWEIWGALSTGAELVVLPYWTARTPVETARVVRDRGITVLNQTPTAFGALTTAVLGEGIDLPELRYVVFGGEKLTPAVVRPWAKRFGLDRPHLINMYGITETTVHATFHRLTEDDLAAEDSVIGRPLPGFTHRIVTEDGRDAATGEPGELWLAGPQVSEGYLNRPELTAERFTTGPPPRYYHSGDLVSRRAGGDLVYQGRADLQVKLRGHRIELSDVEAAVRTHPAVVDAVVWVHEFAPGDSRLVCAYTAPDARALRAHVKTVLPSYMQPSQYLALPELPRTINGKADRASVARAFDERR 5yei A 2.301 BS01 THR B 1 N371 I372 N362 I363 2.7.2.4 0004072,0005524,0005829,0008652,0009085,0009088,0009089,0009090,0016301,0016310,0019877 O69077 29382741 501 ALIVQKFGGTSVGTVERIEQVAEKVKKFREAGDDVVVVVSAMSGETNRLIGLANQIMEQPVPRELDVMVSTGEQVTIALLSMALIKRGVPAVSYTGNQVRILTDSAHTKARILHIDDTHIRADLKAGRVVVVAGFQGVDGNGNITTLGRGGSDTTGVALAAALKADECQIYTDVDGVYTTDPRVVPQARRLDKITFEEMLEMASLGSKVLQIRAVEFAGKYNVPLRVLHSFQEGPGTLITIDPIISGIAFNRDEAKLTIRGVPDTPGVAFKILGPISAANVEVDMIVQNVAHDNTTDFTFTVHRNDYLNALEILKQTAANIGAREAIGDTNIAKVSIVGVGMRSHAGVASRMFEALAKESINIQMISTSEIKVSVVIEEKYLELAVRALHTAFELDA 5yei A 2.301 BS03 THR A 1 T274 P275 A278 Q297 T265 P266 A269 Q288 2.7.2.4 0004072,0005524,0005829,0008652,0009085,0009088,0009089,0009090,0016301,0016310,0019877 O69077 29382741 502 ALIVQKFGGTSVGTVERIEQVAEKVKKFREAGDDVVVVVSAMSGETNRLIGLANQIMEQPVPRELDVMVSTGEQVTIALLSMALIKRGVPAVSYTGNQVRILTDSAHTKARILHIDDTHIRADLKAGRVVVVAGFQGVDGNGNITTLGRGGSDTTGVALAAALKADECQIYTDVDGVYTTDPRVVPQARRLDKITFEEMLEMASLGSKVLQIRAVEFAGKYNVPLRVLHSFQEGPGTLITIDPIISGIAFNRDEAKLTIRGVPDTPGVAFKILGPISAANVEVDMIVQNVAHDNTTDFTFTVHRNDYLNALEILKQTAANIGAREAIGDTNIAKVSIVGVGMRSHAGVASRMFEALAKESINIQMISTSEIKVSVVIEEKYLELAVRALHTAFELDA 5yei B 2.301 BS01 THR B 1 T274 P275 V277 A278 Q297 T25 P26 V28 A29 Q48 2.7.2.4 O69077 29382741 501 EQPIISGIAFNRDEAKLTIRGVPDTPGVAFKILGPISAANVEVDMIVQNVAHDNTTDFTFTVHRNDYLNALEILKQTAANIGAREAIGDTNIAKVSIVGVGMRSHAGVASRMFEALAKESINIQMISTSEIKVSVVIEEKYLELAVRALHTAFELD 5yei B 2.301 BS03 THR A 1 N371 I372 N122 I123 2.7.2.4 O69077 29382741 502 EQPIISGIAFNRDEAKLTIRGVPDTPGVAFKILGPISAANVEVDMIVQNVAHDNTTDFTFTVHRNDYLNALEILKQTAANIGAREAIGDTNIAKVSIVGVGMRSHAGVASRMFEALAKESINIQMISTSEIKVSVVIEEKYLELAVRALHTAFELD 5yei C 2.301 BS01 THR D 1 N371 I372 N362 I363 2.7.2.4 0004072,0005524,0005829,0008652,0009085,0009088,0009089,0009090,0016301,0016310,0019877 O69077 29382741 501 ALIVQKFGGTSVGTVERIEQVAEKVKKFREAGDDVVVVVSAMSGETNRLIGLANQIMEQPVPRELDVMVSTGEQVTIALLSMALIKRGVPAVSYTGNQVRILTDSAHTKARILHIDDTHIRADLKAGRVVVVAGFQGVDGNGNITTLGRGGSDTTGVALAAALKADECQIYTDVDGVYTTDPRVVPQARRLDKITFEEMLEMASLGSKVLQIRAVEFAGKYNVPLRVLHSFQEGPGTLITIDPIISGIAFNRDEAKLTIRGVPDTPGVAFKILGPISAANVEVDMIVQNVAHDNTTDFTFTVHRNDYLNALEILKQTAANIGAREAIGDTNIAKVSIVGVGMRSHAGVASRMFEALAKESINIQMISTSEIKVSVVIEEKYLELAVRALHTAFELDA 5yei C 2.301 BS02 THR C 1 T274 P275 A278 Q297 T265 P266 A269 Q288 2.7.2.4 0004072,0005524,0005829,0008652,0009085,0009088,0009089,0009090,0016301,0016310,0019877 O69077 29382741 501 ALIVQKFGGTSVGTVERIEQVAEKVKKFREAGDDVVVVVSAMSGETNRLIGLANQIMEQPVPRELDVMVSTGEQVTIALLSMALIKRGVPAVSYTGNQVRILTDSAHTKARILHIDDTHIRADLKAGRVVVVAGFQGVDGNGNITTLGRGGSDTTGVALAAALKADECQIYTDVDGVYTTDPRVVPQARRLDKITFEEMLEMASLGSKVLQIRAVEFAGKYNVPLRVLHSFQEGPGTLITIDPIISGIAFNRDEAKLTIRGVPDTPGVAFKILGPISAANVEVDMIVQNVAHDNTTDFTFTVHRNDYLNALEILKQTAANIGAREAIGDTNIAKVSIVGVGMRSHAGVASRMFEALAKESINIQMISTSEIKVSVVIEEKYLELAVRALHTAFELDA 5yei D 2.301 BS01 THR D 1 T274 V277 A278 Q297 T25 V28 A29 Q48 2.7.2.4 O69077 29382741 501 EQPIISGIAFNRDEAKLTIRGVPDTPGVAFKILGPISAANVEVDMIVQNVAHDNTTDFTFTVHRNDYLNALEILKQTAANIGAREAIGDTNIAKVSIVGVGMRSHAGVASRMFEALAKESINIQMISTSEIKVSVVIEEKYLELAVRALHTAFELD 5yei D 2.301 BS02 THR C 1 N371 I372 N122 I123 2.7.2.4 O69077 29382741 501 EQPIISGIAFNRDEAKLTIRGVPDTPGVAFKILGPISAANVEVDMIVQNVAHDNTTDFTFTVHRNDYLNALEILKQTAANIGAREAIGDTNIAKVSIVGVGMRSHAGVASRMFEALAKESINIQMISTSEIKVSVVIEEKYLELAVRALHTAFELD 5yei E 2.301 BS01 THR F 1 T274 V277 A278 Q297 T265 V268 A269 Q288 2.7.2.4 0004072,0005524,0005829,0008652,0009085,0009088,0009089,0009090,0016301,0016310,0019877 O69077 29382741 501 ALIVQKFGGTSVGTVERIEQVAEKVKKFREAGDDVVVVVSAMSGETNRLIGLANQIMEQPVPRELDVMVSTGEQVTIALLSMALIKRGVPAVSYTGNQVRILTDSAHTKARILHIDDTHIRADLKAGRVVVVAGFQGVDGNGNITTLGRGGSDTTGVALAAALKADECQIYTDVDGVYTTDPRVVPQARRLDKITFEEMLEMASLGSKVLQIRAVEFAGKYNVPLRVLHSFQEGPGTLITIDPIISGIAFNRDEAKLTIRGVPDTPGVAFKILGPISAANVEVDMIVQNVAHDNTTDFTFTVHRNDYLNALEILKQTAANIGAREAIGDTNIAKVSIVGVGMRSHAGVASRMFEALAKESINIQMISTSEIKVSVVIEEKYLELAVRALHTAFELDA 5yei E 2.301 BS02 THR F 2 N371 I372 N362 I363 2.7.2.4 0004072,0005524,0005829,0008652,0009085,0009088,0009089,0009090,0016301,0016310,0019877 O69077 29382741 502 ALIVQKFGGTSVGTVERIEQVAEKVKKFREAGDDVVVVVSAMSGETNRLIGLANQIMEQPVPRELDVMVSTGEQVTIALLSMALIKRGVPAVSYTGNQVRILTDSAHTKARILHIDDTHIRADLKAGRVVVVAGFQGVDGNGNITTLGRGGSDTTGVALAAALKADECQIYTDVDGVYTTDPRVVPQARRLDKITFEEMLEMASLGSKVLQIRAVEFAGKYNVPLRVLHSFQEGPGTLITIDPIISGIAFNRDEAKLTIRGVPDTPGVAFKILGPISAANVEVDMIVQNVAHDNTTDFTFTVHRNDYLNALEILKQTAANIGAREAIGDTNIAKVSIVGVGMRSHAGVASRMFEALAKESINIQMISTSEIKVSVVIEEKYLELAVRALHTAFELDA 5yei F 2.301 BS01 THR F 1 N371 I372 N119 I120 2.7.2.4 O69077 29382741 501 IISGIAFNRDEAKLTIRGVPDTPGVAFKILGPISAANVEVDMIVQNVAHDNTTDFTFTVHRNDYLNALEILKQTAANIGAREAIGDTNIAKVSIVGVGMRSHAGVASRMFEALAKESINIQMISTSEIKVSVVIEEKYLELAVRALHTAFE 5yei F 2.301 BS02 THR F 2 T274 P275 V277 A278 Q297 T22 P23 V25 A26 Q45 2.7.2.4 O69077 29382741 502 IISGIAFNRDEAKLTIRGVPDTPGVAFKILGPISAANVEVDMIVQNVAHDNTTDFTFTVHRNDYLNALEILKQTAANIGAREAIGDTNIAKVSIVGVGMRSHAGVASRMFEALAKESINIQMISTSEIKVSVVIEEKYLELAVRALHTAFE 5yei G 2.301 BS01 THR H 1 N371 I372 N362 I363 2.7.2.4 0004072,0005524,0005829,0008652,0009085,0009088,0009089,0009090,0016301,0016310,0019877 O69077 29382741 501 ALIVQKFGGTSVGTVERIEQVAEKVKKFREAGDDVVVVVSAMSGETNRLIGLANQIMEQPVPRELDVMVSTGEQVTIALLSMALIKRGVPAVSYTGNQVRILTDSAHTKARILHIDDTHIRADLKAGRVVVVAGFQGVDGNGNITTLGRGGSDTTGVALAAALKADECQIYTDVDGVYTTDPRVVPQARRLDKITFEEMLEMASLGSKVLQIRAVEFAGKYNVPLRVLHSFQEGPGTLITIDPIISGIAFNRDEAKLTIRGVPDTPGVAFKILGPISAANVEVDMIVQNVAHDNTTDFTFTVHRNDYLNALEILKQTAANIGAREAIGDTNIAKVSIVGVGMRSHAGVASRMFEALAKESINIQMISTSEIKVSVVIEEKYLELAVRALHTAFELDA 5yei G 2.301 BS03 THR G 1 T274 P275 G276 V277 A278 Q297 T265 P266 G267 V268 A269 Q288 2.7.2.4 0004072,0005524,0005829,0008652,0009085,0009088,0009089,0009090,0016301,0016310,0019877 O69077 29382741 503 ALIVQKFGGTSVGTVERIEQVAEKVKKFREAGDDVVVVVSAMSGETNRLIGLANQIMEQPVPRELDVMVSTGEQVTIALLSMALIKRGVPAVSYTGNQVRILTDSAHTKARILHIDDTHIRADLKAGRVVVVAGFQGVDGNGNITTLGRGGSDTTGVALAAALKADECQIYTDVDGVYTTDPRVVPQARRLDKITFEEMLEMASLGSKVLQIRAVEFAGKYNVPLRVLHSFQEGPGTLITIDPIISGIAFNRDEAKLTIRGVPDTPGVAFKILGPISAANVEVDMIVQNVAHDNTTDFTFTVHRNDYLNALEILKQTAANIGAREAIGDTNIAKVSIVGVGMRSHAGVASRMFEALAKESINIQMISTSEIKVSVVIEEKYLELAVRALHTAFELDA 5yei H 2.301 BS01 THR H 1 D273 T274 P275 V277 A278 Q297 D24 T25 P26 V28 A29 Q48 2.7.2.4 O69077 29382741 501 EQPIISGIAFNRDEAKLTIRGVPDTPGVAFKILGPISAANVEVDMIVQNVAHDNTTDFTFTVHRNDYLNALEILKQTAANIGAREAIGDTNIAKVSIVGVGMRSHAGVASRMFEALAKESINIQMISTSEIKVSVVIEEKYLELAVRALHTAFELD 5yei H 2.301 BS03 THR G 1 N371 I372 N122 I123 2.7.2.4 O69077 29382741 503 EQPIISGIAFNRDEAKLTIRGVPDTPGVAFKILGPISAANVEVDMIVQNVAHDNTTDFTFTVHRNDYLNALEILKQTAANIGAREAIGDTNIAKVSIVGVGMRSHAGVASRMFEALAKESINIQMISTSEIKVSVVIEEKYLELAVRALHTAFELD 6f87 A 2.62 BS02 THR A 1 T35 G38 H67 R121 E180 S181 T34 G37 H66 R120 E179 S180 2.7.7.87 0000049,0002949,0003725,0005524,0005737,0006450,0008033,0016779,0061710 Q9UYB2 29650678 402 TIIINVRERIEEWKIRIAAGFIREGKLVAFPTETVYGLGANALDENAVKRIFEAKGRPADNPLIIHIASFEQLEVLAKEIPEEAEMLAKRFWPGPLTLVLPKSEVVPRVITGGLDTVAVRMPAHEIALKLIELSERPIAAPSANISGKPSPTSAHHVAEDFYGKIECIIDGGETRIGVESTVIDLTEWPPVLLRPGGLPLEEIEKVIGEIRIHPAVYGKSVDTAKAPGMKYRHYAPSAEVIVVEGPRDKVRRKIEELIAKFKEEGKKVGVIGSGSYDADEVFYLGDTVEEIARNLFKALRHMDRTGVDVILAEGVEEKGLGLAVMNRLRKASGYRIIKVH 6f87 B 2.62 BS02 THR B 1 T35 V36 G38 H67 R121 E180 S181 R195 T34 V35 G37 H66 R120 E179 S180 R194 2.7.7.87 0000049,0002949,0003725,0005524,0005737,0006450,0008033,0016779,0061710 Q9UYB2 29650678 402 TIIINVRERIEEWKIRIAAGFIREGKLVAFPTETVYGLGANALDENAVKRIFEAKGRPADNPLIIHIASFEQLEVLAKEIPEEAEMLAKRFWPGPLTLVLPKSEVVPRVITGGLDTVAVRMPAHEIALKLIELSERPIAAPSANISGKPSPTSAHHVAEDFYGKIECIIDGGETRIGVESTVIDLTEWPPVLLRPGGLPLEEIEKVIGEIRIHPAVYGKSVDTAKAPGMKYRHYAPSAEVIVVEGPRDKVRRKIEELIAKFKEEGKKVGVIGSGSYDADEVFYLGDTVEEIARNLFKALRHMDRTGVDVILAEGVEEKGLGLAVMNRLRKASGYRIIKVH 6f87 C 2.62 BS02 THR C 1 T35 G38 H67 R121 E180 S181 R195 T34 G37 H66 R120 E179 S180 R194 2.7.7.87 0000049,0002949,0003725,0005524,0005737,0006450,0008033,0016779,0061710 Q9UYB2 29650678 402 TIIINVRERIEEWKIRIAAGFIREGKLVAFPTETVYGLGANALDENAVKRIFEAKGRPADNPLIIHIASFEQLEVLAKEIPEEAEMLAKRFWPGPLTLVLPKSEVVPRVITGGLDTVAVRMPAHEIALKLIELSERPIAAPSANISGKPSPTSAHHVAEDFYGKIECIIDGGETRIGVESTVIDLTEWPPVLLRPGGLPLEEIEKVIGEIRIHPAVYGKSVDTAKAPGMKYRHYAPSAEVIVVEGPRDKVRRKIEELIAKFKEEGKKVGVIGSGSYDADEVFYLGDTVEEIARNLFKALRHMDRTGVDVILAEGVEEKGLGLAVMNRLRKASGYRIIKVH 6f87 D 2.62 BS02 THR D 1 T35 G38 I65 R121 E180 S181 R195 T34 G37 I64 R120 E179 S180 R194 2.7.7.87 0000049,0002949,0003725,0005524,0005737,0006450,0008033,0016779,0061710 Q9UYB2 29650678 402 TIIINVRERIEEWKIRIAAGFIREGKLVAFPTETVYGLGANALDENAVKRIFEAKGRPADNPLIIHIASFEQLEVLAKEIPEEAEMLAKRFWPGPLTLVLPKSEVVPRVITGGLDTVAVRMPAHEIALKLIELSERPIAAPSANISGKPSPTSAHHVAEDFYGKIECIIDGGETRIGVESTVIDLTEWPPVLLRPGGLPLEEIEKVIGEIRIHPAVYGKSVDTAKAPGMKYRHYAPSAEVIVVEGPRDKVRRKIEELIAKFKEEGKKVGVIGSGSYDADEVFYLGDTVEEIARNLFKALRHMDRTGVDVILAEGVEEKGLGLAVMNRLRKASGYRIIKVH 6f89 A 2.81 BS02 THR A 1 T35 H67 R121 A141 E180 S181 T35 H67 R121 A141 E180 S181 2.7.7.87 0000049,0002949,0003725,0005524,0005737,0006450,0008033,0016779,0061710 Q9UYB2 29650678 402 MTIIINVRERIEEWKIRIAAGFIREGKLVAFPTETVYGLGANALDENAVKRIFEAKGRPADNPLIIHIASFEQLEVLAKEIPEEAEMLAKRFWPGPLTLVLPKSEVVPRVITGGLDTVAVRMPAHEIALKLIELSERPIAAPSANISGKPSPTSAHHVAEDFYGKIECIIDGGETRIGVESTVIDLTEWPPVLLRPGGLPLEEIEKVIGEIRIHPAVYGKSVDTAKAPGMKYRAAPSAEVIVVEGPRDKVRRKIEELIAKFKEEGKKVGVIGSGSYDADEVFYLGDTVEEIARNLFKALRHMDRTGVDVILAEGVEEKGLGLAVMNRLRKASGYRIIKVHHHHH 6f89 B 2.81 BS02 THR B 1 T35 G38 H67 R121 S181 T35 G38 H67 R121 S181 2.7.7.87 0000049,0002949,0003725,0005524,0005737,0006450,0008033,0016779,0061710 Q9UYB2 29650678 402 MTIIINVRERIEEWKIRIAAGFIREGKLVAFPTETVYGLGANALDENAVKRIFEAKGRPADNPLIIHIASFEQLEVLAKEIPEEAEMLAKRFWPGPLTLVLPKSEVVPRVITGGLDTVAVRMPAHEIALKLIELSERPIAAPSANISGKPSPTSAHHVAEDFYGKIECIIDGGETRIGVESTVIDLTEWPPVLLRPGGLPLEEIEKVIGEIRIHPAVYGKSVAEVIVVEGPRDKVRRKIEELIAKFKEEGKKVGVIGSGSYDADEVFYLGDTVEEIARNLFKALRHMDRTGVDVILAEGVEEKGLGLAVMNRLRKASGYRIIKVHH 6f8y A 2.86 BS01 THR A 1 T35 H67 R121 E180 S181 T34 H66 R120 E179 S180 2.7.7.87 0000049,0002949,0003725,0005524,0005737,0006450,0008033,0016779,0061710 Q9UYB2 29650678 401 TIIINVRERIEEWKIRIAAGFIREGKLVAFPTETVYGLGANALDENAVKRIFEAKGRPADNPLIIHIASFEQLEVLAKEIPEEAEMLAKRFWPGPLTLVLPKSEVVPRVITGGLDTVAVRMPAHEIALKLIELSERPIAAPSANISGKPSPTSAHHVAEDFYGKIECIIDGGETRIGVESTVIDLTEWPPVLLRPGGLPLEEIEKVIGEIRIHPAVYGKSVDTAKAPGMKYRHYAPSAEVIVVEGPRDKVRRKIEELIAKFKEEGKKVGVIGSGSYDADEVFYLGDTVEEIARNLFKALRHMDRTGVDVILAEGVEEKGLGLAVMNRLRKASGYRIIKVH 6f8y B 2.86 BS01 THR B 1 T35 V36 R121 E180 S181 R195 T34 V35 R120 E179 S180 R194 2.7.7.87 0000049,0002949,0003725,0005524,0005737,0006450,0008033,0016779,0061710 Q9UYB2 29650678 401 TIIINVRERIEEWKIRIAAGFIREGKLVAFPTETVYGLGANALDENAVKRIFEAKGRPADNPLIIHIASFEQLEVLAKEIPEEAEMLAKRFWPGPLTLVLPKSEVVPRVITGGLDTVAVRMPAHEIALKLIELSERPIAAPSANISGKPSPTSAHHVAEDFYGKIECIIDGGETRIGVESTVIDLTEWPPVLLRPGGLPLEEIEKVIGEIRIHPAVYGKSVDTAKAPGMKYRHYAPSAEVIVVEGPRDKVRRKIEELIAKFKEEGKKVGVIGSGSYDADEVFYLGDTVEEIARNLFKALRHMDRTGVDVILAEGVEEKGLGLAVMNRLRKASGYRIIKVH 6f8y C 2.86 BS01 THR C 1 T35 H67 R121 E180 S181 R195 T34 H66 R120 E179 S180 R194 2.7.7.87 0000049,0002949,0003725,0005524,0005737,0006450,0008033,0016779,0061710 Q9UYB2 29650678 401 TIIINVRERIEEWKIRIAAGFIREGKLVAFPTETVYGLGANALDENAVKRIFEAKGRPADNPLIIHIASFEQLEVLAKEIPEEAEMLAKRFWPGPLTLVLPKSEVVPRVITGGLDTVAVRMPAHEIALKLIELSERPIAAPSANISGKPSPTSAHHVAEDFYGKIECIIDGGETRIGVESTVIDLTEWPPVLLRPGGLPLEEIEKVIGEIRIHPAVYGKSVDTAKAPGMKYRHYAPSAEVIVVEGPRDKVRRKIEELIAKFKEEGKKVGVIGSGSYDADEVFYLGDTVEEIARNLFKALRHMDRTGVDVILAEGVEEKGLGLAVMNRLRKASGYRIIKVHH 6f8y D 2.86 BS01 THR D 1 T35 V36 G38 H67 R121 E180 S181 R195 T34 V35 G37 H66 R120 E179 S180 R194 2.7.7.87 0000049,0002949,0003725,0005524,0005737,0006450,0008033,0016779,0061710 Q9UYB2 29650678 401 TIIINVRERIEEWKIRIAAGFIREGKLVAFPTETVYGLGANALDENAVKRIFEAKGRPADNPLIIHIASFEQLEVLAKEIPEEAEMLAKRFWPGPLTLVLPKSEVVPRVITGGLDTVAVRMPAHEIALKLIELSERPIAAPSANISGKPSPTSAHHVAEDFYGKIECIIDGGETRIGVESTVIDLTEWPPVLLRPGGLPLEEIEKVIGEIRIHPAVYGKSVDTAKAPGMKYRHYAPSAEVIVVEGPRDKVRRKIEELIAKFKEEGKKVGVIGSGSYDADEVFYLGDTVEEIARNLFKALRHMDRTGVDVILAEGVEEKGLGLAVMNRLRKASGYRIIKVH 6gyp B 3.6 BS05 THR B 1 E56 D60 E4 D8 ? 0000775,0000776,0000921,0000981,0003677,0005515,0005634,0005694,0006355,0006357,0007094,0008270,0008301,0019237,0031518,0042802,0046872,0051382 P40969 30478265 705 SSKEYLPDLLLFWQNYEYWITNIGLYKTKQRDLTRTPANLDTDTEECMFWMNYLQKDQSFQLMNFAMENLGALYFGSIGDISELYLRVEQYWDRRADKNHSVDGKYWDALIWSVFTMCIYYMPVEKLAEIFSVYPLHEYLGSNKRLNWEDGMQLVMCQNFARCSLFQLKQCDFMAHPDIRLVQAYLILATTTFPYDEPLLANSLLTQCIHTFKNFHVDDFRPLLNDDPVESIAKVTLGRIFYRLCGCDYLQSGPRKPIALHTEVSSLNVDVYREENSTEVLYWKIISLDRDLDQYLNKSSKPPLKTLDAIRRELDIFQYKVDSLEEDFRSNNSRFQKFIALFQISTVSWKLFKMYLIYYDTADSLLKVIHYSKVIISLIVNNFHAKSEFFNRHPMVMQTITRVVSFISFYQIFVESAAVKQLLVDLTELTANLPTIFGSKLDKLVYLTERLSKLKLLWDKVQLLDSGDSFYHPVFKILQNDIKIIELKNDEMFSLIKGLGSLVPLNSDFRTIVEEFQSEYNISDILS 6tth A 2.6 BS02 THR A 1 R43 N44 N70 H464 I469 F470 R22 N23 N49 H343 I348 F349 R73 K270 T328 R52 K149 T207 2.7.10.2,2.7.11.1,2.7.1.40 0000287,0003723,0003729,0003824,0004713,0004743,0005515,0005524,0005576,0005634,0005737,0005739,0005791,0005829,0005929,0006096,0006417,0012501,0016301,0016310,0023026,0030955,0031982,0032869,0034774,0045296,0046872,0061621,0062023,0070062,1903561,1903672,1904813,2000767 P14618 31877353 602 MADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP 6tth B 2.6 BS02 THR B 1 R43 N44 N70 H464 I469 F470 R22 N23 N49 H343 I348 F349 R73 K270 T328 R52 K149 T207 2.7.10.2,2.7.11.1,2.7.1.40 0000287,0003723,0003729,0003824,0004713,0004743,0005515,0005524,0005576,0005634,0005737,0005739,0005791,0005829,0005929,0006096,0006417,0012501,0016301,0016310,0023026,0030955,0031982,0032869,0034774,0045296,0046872,0061621,0062023,0070062,1903561,1903672,1904813,2000767 P14618 31877353 602 MADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP 6tth C 2.6 BS01 THR C 1 R43 N44 N70 H464 I469 F470 R22 N23 N49 H343 I348 F349 R73 K270 T328 R52 K149 T207 2.7.10.2,2.7.11.1,2.7.1.40 0000287,0003723,0003729,0003824,0004713,0004743,0005515,0005524,0005576,0005634,0005737,0005739,0005791,0005829,0005929,0006096,0006417,0012501,0016301,0016310,0023026,0030955,0031982,0032869,0034774,0045296,0046872,0061621,0062023,0070062,1903561,1903672,1904813,2000767 P14618 31877353 2001 MADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP 6tth D 2.6 BS01 THR D 1 R43 N44 N70 H464 I469 F470 R22 N23 N49 H343 I348 F349 R73 K270 T328 R52 K149 T207 2.7.10.2,2.7.11.1,2.7.1.40 0000287,0003723,0003729,0003824,0004713,0004743,0005515,0005524,0005576,0005634,0005737,0005739,0005791,0005829,0005929,0006096,0006417,0012501,0016301,0016310,0023026,0030955,0031982,0032869,0034774,0045296,0046872,0061621,0062023,0070062,1903561,1903672,1904813,2000767 P14618 31877353 2001 MADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP 6ywz A 2.12 BS02 THR A 1 V677 L678 H735 V27 L28 H79 ? Q9Y566 34163995 802 GPLGSDYIIKEKTVLLQKKDSEGFGFVLRGAKEFTPTPAFPALQYLESVDEGGVAWRAGLRMGDFLIEVNGQNVVKVGHRQVVNMIRQGGNTLMVKVVMVTR 6ywz B 2.12 BS02 THR B 1 V677 L678 H735 V27 L28 H85 ? Q9Y566 34163995 803 GPLGSDYIIKEKTVLLQKKDSEGFGFVLRGAKAQTPIEEFTPTPAFPALQYLESVDEGGVAWRAGLRMGDFLIEVNGQNVVKVGHRQVVNMIRQGGNTLMVKVVMVTRH 6yx1 A 1.8 BS02 THR A 1 V677 L678 H735 V27 L28 H78 ? Q9Y566 34163995 802 GPLGSDYIIKEKTVLLQKKDSEGFGFVLRGAEFTPTPAFPALQYLESVDEGGVAWRAGLRMGDFLIEVNGQNVVKVGHRQVVNMIRQGGNTLMVKVVMVTR 6yx1 B 1.8 BS02 THR B 1 V677 L678 H735 R736 V739 V27 L28 H85 R86 V89 ? Q9Y566 34163995 802 GPLGSDYIIKEKTVLLQKKDSEGFGFVLRGAKAQTPIEEFTPTPAFPALQYLESVDEGGVAWRAGLRMGDFLIEVNGQNVVKVGHRQVVNMIRQGGNTLMVKVVMVTRH 7eps A 2.102 BS02 THR A 1 S81 S119 Y144 G184 T185 T186 S76 S114 Y139 G179 T180 T181 34254784 402 PKILIIGANGQIGSELALALAERYGRENVIASDVVPTGRHVHLPFEVLNATDRGELATVVERHGITQVYLLAAALSATGEKAPQWAWNLNMTSLLNVLELARQTGLEKIFWPSSIAAFGPTTPAGQTPQKTVMEPTTVYGISKQAGEGWCRWYHANHGVDVRSIRYPGLISHKTPPGGGTTDYAVDIFHAAVTGEPYTCFLKEDEALPMMYMPDAIRATIELMEAPADKLSERGSYNIAGMSFTPAQIAAAIREQVPGFQIRYEPDYRQAIAQGWPDSIDDSVARADWGWKAQYGLKEMVADMLANLKAT 7eps B 2.102 BS02 THR B 1 S81 S119 Y144 G184 T185 T186 W280 S72 S110 Y135 G175 T176 T177 W271 34254784 402 PKILIIGANGQIGSELALALAERYGRENVIASDVVPTGLPFEVLNATDRGELATVVERHGITQVYLLAAALSATGEKAPQWAWNLNMTSLLNVLELARQTGLEKIFWPSSIAAFGPTTPAGQTPQKTVMEPTTVYGISKQAGEGWCRWYHANHGVDVRSIRYPGLISHKTPPGGGTTDYAVDIFHAAVTGEPYTCFLKEDEALPMMYMPDAIRATIELMEAPADKLSERGSYNIAGMSFTPAQIAAAIREQVPGFQIRYEPDYRQAIAQGWPDSIDDSVARADWGWKAQYGLKEMVADMLANLKAT 7eps C 2.102 BS02 THR C 1 S81 S119 Y144 G184 T185 T186 S76 S114 Y139 G179 T180 T181 34254784 402 PKILIIGANGQIGSELALALAERYGRENVIASDVVPTGRHVHLPFEVLNATDRGELATVVERHGITQVYLLAAALSATGEKAPQWAWNLNMTSLLNVLELARQTGLEKIFWPSSIAAFGPTTPAGQTPQKTVMEPTTVYGISKQAGEGWCRWYHANHGVDVRSIRYPGLISHKTPPGGGTTDYAVDIFHAAVTGEPYTCFLKEDEALPMMYMPDAIRATIELMEAPADKLSERGSYNIAGMSFTPAQIAAAIREQVPGFQIRYEPDYRQAIAQGWPDSIDDSVARADWGWKAQYGLKEMVADMLANLKAT 7eps D 2.102 BS02 THR D 1 S81 S119 Y144 G184 T185 T186 W280 S71 S109 Y134 G174 T175 T176 W270 34254784 402 PKILIIGANGQIGSELALALAERYGRENVIASDVVPTLPFEVLNATDRGELATVVERHGITQVYLLAAALSATGEKAPQWAWNLNMTSLLNVLELARQTGLEKIFWPSSIAAFGPTTPAGQTPQKTVMEPTTVYGISKQAGEGWCRWYHANHGVDVRSIRYPGLISHKTPPGGGTTDYAVDIFHAAVTGEPYTCFLKEDEALPMMYMPDAIRATIELMEAPADKLSERGSYNIAGMSFTPAQIAAAIREQVPGFQIRYEPDYRQAIAQGWPDSIDDSVARADWGWKAQYGLKEMVADMLANLKAT 7uio Bc 3.3 BS01 THR Bc 1 E104 L106 K107 E104 L106 K107 ? 0000122,0000979,0003712,0003713,0005515,0005634,0006357,0016592,0032968,0034605,0045944,0051123,0060261,0061629,0070847 P40356 36731470 108 MDSIIPAGVKLDDLQVILAKNENETRDKVCKQINEARDEILPLRLQFNEFIQIMANIDQEGSKQADRMAKYLHIRDKILQLNDRFQTLSSHLEALQPLFSTVPEYLK