3n9r A 1.8 BS02 TD3 A 1 H83 H180 G181 K184 H210 G211 S213 N253 D255 T256 H83 H170 G171 K174 H200 G201 S203 N243 D245 T246 C69 E70 G136 H180 A226 N253 C69 E70 G136 H170 A216 N243 0004332,0005975,0006096,0008270,0016832,0030388 Ki=5.5uM -logKd/Ki=7.15, Ki=70nM 20929256 311 MLVKGNEILLKAHKEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYMGIDMAVGMVKIMCERYPHIPVALHLDHGTTFESCEKAVKAGFTSVMIDASHHAFEENLELTSKVVKMAHNAGVSVEAELGRLMGIAVLVNPKEAEQFVKESQVDYLAPAIGTSHGAFKFKGEPKLDFERLQEVKRLTNIPLVLHGASAIPDNVRKSYLDAGGDLKGSKGVPFEFLQESVKGGINKVNTDTDLRIAFIAEVRKVANEDKSQFDLRKFFSPAQLALKNVVKERMKLLGSANKI 3n9r B 1.8 BS02 TD3 B 1 H83 H180 G181 K184 H210 G211 S213 N253 D255 T256 H83 H170 G171 K174 H200 G201 S203 N243 D245 T246 C69 E70 G136 H180 A226 N253 C69 E70 G136 H170 A216 N243 0004332,0005975,0006096,0008270,0016832,0030388 Ki=5.5uM 20929256 311 MLVKGNEILLKAHKEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYMGIDMAVGMVKIMCERYPHIPVALHLDHGTTFESCEKAVKAGFTSVMIDASHHAFEENLELTSKVVKMAHNAGVSVEAELGRLMGIAVLVNPKEAEQFVKESQVDYLAPAIGTSHGAFKFKGEPKLDFERLQEVKRLTNIPLVLHGASAIPDNVRKSYLDAGGDLKGSKGVPFEFLQESVKGGINKVNTDTDLRIAFIAEVRKVANEDKSQFDLRKFFSPAQLALKNVVKERMKLLGSANKI 3n9r e 1.8 BS02 TD3 e 1 D82 H83 H180 G181 K184 H210 G211 S213 N253 D255 T256 D82 H83 H170 G171 K174 H200 G201 S203 N243 D245 T246 0004332,0005975,0006096,0008270,0016832,0030388 -logKd/Ki=7.15, Ki=70nM 20929256 311 MLVKGNEILLKAHKEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYMGIDMAVGMVKIMCERYPHIPVALHLDHGTTFESCEKAVKAGFTSVMIDASHHAFEENLELTSKVVKMAHNAGVSVEAELGRLMGIAVLVNPKEAEQFVKESQVDYLAPAIGTSHGAFKFKGEPKLDFERLQEVKRLTNIPLVLHGASAIPDNVRKSYLDAGGDLKGSKGVPFEFLQESVKGGINKVNTDTDLRIAFIAEVRKVANEDKSQFDLRKFFSPAQLALKNVVKERMKLLGSANKI 3n9r j 1.8 BS02 TD3 j 1 D82 H83 H180 G181 K184 H210 G211 A212 S213 N253 D255 T256 D82 H83 H170 G171 K174 H200 G201 A202 S203 N243 D245 T246 0004332,0005975,0006096,0008270,0016832,0030388 20929256 311 MLVKGNEILLKAHKEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYMGIDMAVGMVKIMCERYPHIPVALHLDHGTTFESCEKAVKAGFTSVMIDASHHAFEENLELTSKVVKMAHNAGVSVEAELGRLMGIAVLVNPKEAEQFVKESQVDYLAPAIGTSHGAFKFKGEPKLDFERLQEVKRLTNIPLVLHGASAIPDNVRKSYLDAGGDLKGSKGVPFEFLQESVKGGINKVNTDTDLRIAFIAEVRKVANEDKSQFDLRKFFSPAQLALKNVVKERMKLLGSANKI 3n9r K 1.8 BS02 TD3 K 1 H83 H180 G181 K184 H210 G211 S213 N253 D255 T256 H83 H170 G171 K174 H200 G201 S203 N243 D245 T246 0004332,0005975,0006096,0008270,0016832,0030388 Ki=5.5uM 20929256 311 MLVKGNEILLKAHKEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYMGIDMAVGMVKIMCERYPHIPVALHLDHGTTFESCEKAVKAGFTSVMIDASHHAFEENLELTSKVVKMAHNAGVSVEAELGRLMGIAVLVNPKEAEQFVKESQVDYLAPAIGTSHGAFKFKGEPKLDFERLQEVKRLTNIPLVLHGASAIPDNVRKSYLDAGGDLKGSKGVPFEFLQESVKGGINKVNTDTDLRIAFIAEVRKVANEDKSQFDLRKFFSPAQLALKNVVKERMKLLGSANKI 3n9r P 1.8 BS02 TD3 P 1 H83 H180 G181 K184 H210 G211 S213 N253 D255 T256 H83 H170 G171 K174 H200 G201 S203 N243 D245 T246 0004332,0005975,0006096,0008270,0016832,0030388 Ki=5.5uM 20929256 311 MLVKGNEILLKAHKEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYMGIDMAVGMVKIMCERYPHIPVALHLDHGTTFESCEKAVKAGFTSVMIDASHHAFEENLELTSKVVKMAHNAGVSVEAELGRLMGIAVLVNPKEAEQFVKESQVDYLAPAIGTSHGAFKFKGEPKLDFERLQEVKRLTNIPLVLHGASAIPDNVRKSYLDAGGDLKGSKGVPFEFLQESVKGGINKVNTDTDLRIAFIAEVRKVANEDKSQFDLRKFFSPAQLALKNVVKERMKLLGSANKI 3n9r U 1.8 BS02 TD3 U 1 N23 D82 H83 H180 G181 K184 H210 G211 S213 N253 D255 T256 N23 D82 H83 H170 G171 K174 H200 G201 S203 N243 D245 T246 0004332,0005975,0006096,0008270,0016832,0030388 Ki=5.5uM 20929256 311 MLVKGNEILLKAHKEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYMGIDMAVGMVKIMCERYPHIPVALHLDHGTTFESCEKAVKAGFTSVMIDASHHAFEENLELTSKVVKMAHNAGVSVEAELGRLMGIAVLVNPKEAEQFVKESQVDYLAPAIGTSHGAFKFKGEPKLDFERLQEVKRLTNIPLVLHGASAIPDNVRKSYLDAGGDLKGSKGVPFEFLQESVKGGINKVNTDTDLRIAFIAEVRKVANEDKSQFDLRKFFSPAQLALKNVVKERMKLLGSANKI 3n9r Z 1.8 BS02 TD3 Z 1 D82 H83 H180 G181 K184 H210 G211 A212 S213 N253 D255 T256 D82 H83 H170 G171 K174 H200 G201 A202 S203 N243 D245 T246 0004332,0005975,0006096,0008270,0016832,0030388 Ki=5.5uM 20929256 311 MLVKGNEILLKAHKEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYMGIDMAVGMVKIMCERYPHIPVALHLDHGTTFESCEKAVKAGFTSVMIDASHHAFEENLELTSKVVKMAHNAGVSVEAELGRLMGIAVLVNPKEAEQFVKESQVDYLAPAIGTSHGAFKFKGEPKLDFERLQEVKRLTNIPLVLHGASAIPDNVRKSYLDAGGDLKGSKGVPFEFLQESVKGGINKVNTDTDLRIAFIAEVRKVANEDKSQFDLRKFFSPAQLALKNVVKERMKLLGSANKI