1c14 A 2.0 BS02 TCL A 1 G93 A95 Y146 Y156 A196 A197 I200 F203 G92 A94 Y145 Y155 A195 A196 I199 F202 1.3.1.9 0004318,0005515,0005829,0006633,0008610,0009102,0016020,0016491,0030497,0032991,0042802,0046677,0051289,0070404,1902494 ic50=120nM IC50=430nM P0AEK4 10595560 502 GFLSGKRILVTGVASKLSIAYGIAQAMHREGAELAFTYQNDKLKGRVEEFAAQLGSDIVLQCDVAEDASIDTMFAELGKVWPKFDGFVHSIGFAPGDQLDGDYVNAVTREGFKIAHDISSYSFVAMAKACRSMLNPGSALLTLSYLGAERAIPNYNVMGLAKASLEANVRYMANAMGPEGVRVNAISAGPIRTLAASGIKDFRKMLAHCEAVTPIRRTVTIEDVGNSAAFLCSDLSAGISGEVVHVDGGFSIAAMN 1c14 B 2.0 BS02 TCL B 1 G1093 A1095 Y1146 Y1156 P1191 A1196 A1197 I1200 F1203 G92 A94 Y145 Y155 P190 A195 A196 I199 F202 S1145 Y1156 M1159 K1163 I1200 S144 Y155 M158 K162 I199 1.3.1.9 0004318,0005515,0005829,0006633,0008610,0009102,0016020,0016491,0030497,0032991,0042802,0046677,0051289,0070404,1902494 ic50=120nM IC50=430nM P0AEK4 10595560 1502 GFLSGKRILVTGVASKLSIAYGIAQAMHREGAELAFTYQNDKLKGRVEEFAAQLGSDIVLQCDVAEDASIDTMFAELGKVWPKFDGFVHSIGFAPGDQLDGDYVNAVTREGFKIAHDISSYSFVAMAKACRSMLNPGSALLTLSYLGAERAIPNYNVMGLAKASLEANVRYMANAMGPEGVRVNAISAGPIRTLAASGIKDFRKMLAHCEAVTPIRRTVTIEDVGNSAAFLCSDLSAGISGEVVHVDGGFSIAAMN 1d7o A 1.9 BS02 TCL A 1 N139 G140 Y188 Y198 N129 G130 Y178 Y188 Y198 K206 Y188 K196 1.3.1.9 0004318,0006633 P80030 10610777 502 GLPIDLRGKRAFIAGIADDNGYGWAVAKSLAAAGAEILVGTWVPALNIFETSLRRGKFDQSRVLPDGSLMEIKKVYPLDAVFDNPEDVPEDVKANKRYAGSSNWTVQEAAECVRQDFGSIDILVHSLANGPEVSKPLLETSRKGYLAAISASSYSFVSLLSHFLPIMNPGGASISLTYIASERIIPGYGGGMSSAKAALESDTRVLAFEAGRKQNIRVNTISAGPLGSRAAKAIGFIDTMIEYSYNNAPIQKTLTADEVGNAAAFLVSPLASAITGATIYVDNGLNSMGVALDSPVF 1d8a A 2.2 BS02 TCL A 1 G93 F94 A95 L100 Y146 Y156 P191 A196 A197 F203 G92 F93 A94 L99 Y145 Y155 P190 A195 A196 F202 S145 Y156 M159 K163 I200 S144 Y155 M158 K162 I199 1.3.1.9 0004318,0005515,0005829,0006633,0008610,0009102,0016020,0016491,0030497,0032991,0042802,0046677,0051289,0070404,1902494 IC50=430nM P0AEK4 10201369 502 GFLSGKRILVTGVASKLSIAYGIAQAMHREGAELAFTYQNDKLKGRVEEFAAQLGSDIVLQCDVAEDASIDTMFAELGKVWPKFDGFVHSIGFAPGDQLDGDYVNAVTREGFKIAHDISSYSFVAMAKACRSMLNPGSALLTLSYLGAERAIPNYNVMGLAKASLEANVRYMANAMGPEGVRVNAISAGPIRTLAASGIKDFRKMLAHCEAVTPIRRTVTIEDVGNSAAFLCSDLSAGISGEVVHVDGGFSIAAMNE 1d8a B 2.2 BS02 TCL B 1 G93 A95 Y146 Y156 P191 A196 F203 G92 A94 Y145 Y155 P190 A195 F202 S145 Y156 M159 K163 I200 S144 Y155 M158 K162 I199 1.3.1.9 0004318,0005515,0005829,0006633,0008610,0009102,0016020,0016491,0030497,0032991,0042802,0046677,0051289,0070404,1902494 IC50=430nM P0AEK4 10201369 504 GFLSGKRILVTGVASKLSIAYGIAQAMHREGAELAFTYQNDKLKGRVEEFAAQLGSDIVLQCDVAEDASIDTMFAELGKVWPKFDGFVHSIGFAPGDQLDGDYVNAVTREGFKIAHDISSYSFVAMAKACRSMLNPGSALLTLSYLGAERAIPNYNVMGLAKASLEANVRYMANAMGPEGVRVNAISAGPIRTLAASGIKDFRKMLAHCEAVTPIRRTVTIEDVGNSAAFLCSDLSAGISGEVVHVDGGFSIAAMNE 1nhg A 2.43 BS02 TCL A 1 A217 N218 A219 Y267 Y277 A319 A320 I323 A121 N122 A123 Y171 Y181 A223 A224 I227 Y277 K285 Y181 K189 1.3.1.9 0004318,0006633 Ki=0.05uM -logKd/Ki=7.30, Ki=0.05uM IC50=49nM Q9BH77 11792710 500 EDICFIAGIGDTNGYGWGIAKELSKRNVKIIFGIWPPVYNIFMKNYKNGKFDNDMIIDKDKKMNILDMLPFDASFDTANDIDEETKNNKRYNMLQNYTIEDVANLIHQKYGKINMLVHSLANAKEVQKDLLNTSRKGYLDALSKSSYSLISLCKYFVNIMKPQSSIISLTYHASQKVVPGYGGGMSSAKAALESDTRVLAYHLGRNYNIRINTISAGPLKSRAATAINK 1nhg B 2.43 BS02 TCL B 1 A217 N218 Y267 Y277 A319 A121 N122 Y171 Y181 A223 Y277 K285 Y181 K189 1.3.1.9 0004318,0006633 Ki=0.05uM IC50=49nM Q9BH77 11792710 600 EDICFIAGIGDTNGYGWGIAKELSKRNVKIIFGIWPPVYNIFMKNYKNGKFDNDMIIDKDKKMNILDMLPFDASFDTANDIDEETKNNKRYNMLQNYTIEDVANLIHQKYGKINMLVHSLANAKEVQKDLLNTSRKGYLDALSKSSYSLISLCKYFVNIMKPQSSIISLTYHASQKVVPGYGGGMSSAKAALESDTRVLAYHLGRNYNIRINTISAGPLKSRAATAINK 1p45 A 2.6 BS02 TCL A 1 G96 M98 M103 F149 Y158 G95 M97 M102 F148 Y157 Y158 K165 Y157 K164 1.3.1.9 0004318,0005504,0005886,0006633,0009274,0016491,0030497,0046677,0050343,0070403,0071768 Ki=220nM, IC50=1000nM P9WGR1 12606558 400 TGLLDGKRILVSGIITDSSIAFHIARVAQEQGAQLVLTGFDRLRLIQRITDRLPAKAPLLELDVQNEEHLASLAGRVTEAIGAGNKLDGVVHSIGFMPQTGMGINPFFDAPYADVSKGIHISAYSYASMAKALLPIMNPGGSIVGMDFDPSRAMPAYNWMTVAKSALESVNRFVAREAGKYGVRSNLVAAGPIRTLAMSAIVGGALGEEAGAQIQLLEEGWDQRAPIGWNMKDATPVAKTVCALLSDWLPATTGDIIYADGGAHTQLL 1p45 A 2.6 BS03 TCL A 2 M103 G104 M199 I215 L218 M102 G103 M198 I214 L217 Y158 K165 Y157 K164 1.3.1.9 0004318,0005504,0005886,0006633,0009274,0016491,0030497,0046677,0050343,0070403,0071768 Ki=220nM, IC50=1000nM P9WGR1 12606558 450 TGLLDGKRILVSGIITDSSIAFHIARVAQEQGAQLVLTGFDRLRLIQRITDRLPAKAPLLELDVQNEEHLASLAGRVTEAIGAGNKLDGVVHSIGFMPQTGMGINPFFDAPYADVSKGIHISAYSYASMAKALLPIMNPGGSIVGMDFDPSRAMPAYNWMTVAKSALESVNRFVAREAGKYGVRSNLVAAGPIRTLAMSAIVGGALGEEAGAQIQLLEEGWDQRAPIGWNMKDATPVAKTVCALLSDWLPATTGDIIYADGGAHTQLL 1p45 B 2.6 BS02 TCL B 1 G96 M98 M103 F149 Y158 M161 A198 I202 G95 M97 M102 F148 Y157 M160 A197 I201 Y158 K165 Y157 K164 1.3.1.9 0004318,0005504,0005886,0006633,0009274,0016491,0030497,0046677,0050343,0070403,0071768 Ki=220nM, IC50=1000nM P9WGR1 12606558 500 TGLLDGKRILVSGIITDSSIAFHIARVAQEQGAQLVLTGFDRLRLIQRITDRLPAKAPLLELDVQNEEHLASLAGRVTEAIGAGNKLDGVVHSIGFMPQTGMGINPFFDAPYADVSKGIHISAYSYASMAKALLPIMNPGGSIVGMDFDPSRAMPAYNWMTVAKSALESVNRFVAREAGKYGVRSNLVAAGPIRTLAMSAIVGGALGEEAGAQIQLLEEGWDQRAPIGWNMKDATPVAKTVCALLSDWLPATTGDIIYADGGAHTQLL 1qg6 A 1.9 BS02 TCL A 1 G93 A95 L100 Y146 Y156 A196 I200 G92 A94 L99 Y145 Y155 A195 I199 S145 Y156 M159 K163 I200 S144 Y155 M158 K162 I199 1.3.1.9 0004318,0005515,0005829,0006633,0008610,0009102,0016020,0016491,0030497,0032991,0042802,0046677,0051289,0070404,1902494 Kd=22pM IC50=430nM P0AEK4 10493822 601 GFLSGKRILVTGVASKLSIAYGIAQAMHREGAELAFTYQNDKLKGRVEEFAAQLGSDIVLQCDVAEDASIDTMFAELGKVWPKFDGFVHSIGFAPGDQLDGDYVNAVTREGFKIAHDISSYSFVAMAKACRSMLNPGSALLTLSYLGAERAIPNYNVMGLAKASLEANVRYMANAMGPEGVRVNAISAGPIRTLAASGIKDFRKMLAHCEAVTPIRRTVTIEDVGNSAAFLCSDLSAGISGEVVHVDGGFSIAAMNE 1qg6 B 1.9 BS02 TCL B 1 G93 A95 L100 Y146 Y156 A196 I200 G92 A94 L99 Y145 Y155 A195 I199 S145 Y156 M159 K163 I200 S144 Y155 M158 K162 I199 1.3.1.9 0004318,0005515,0005829,0006633,0008610,0009102,0016020,0016491,0030497,0032991,0042802,0046677,0051289,0070404,1902494 Kd=22pM IC50=430nM P0AEK4 10493822 602 GFLSGKRILVTGVASKLSIAYGIAQAMHREGAELAFTYQNDKLKGRVEEFAAQLGSDIVLQCDVAEDASIDTMFAELGKVWPKFDGFVHSIGFAPGDQLDGDYVNAVTREGFKIAHDISSYSFVAMAKACRSMLNPGSALLTLSYLGAERAIPNYNVMGLAKASLEANVRYMANAMGPEGVRVNAISAGPIRTLAASGIKDFRKMLAHCEAVTPIRRTVTIEDVGNSAAFLCSDLSAGISGEVVHVDGGFSIAAMNE 1qg6 C 1.9 BS02 TCL C 1 G93 A95 L100 Y146 Y156 A196 I200 G92 A94 L99 Y145 Y155 A195 I199 S145 Y156 M159 K163 I200 S144 Y155 M158 K162 I199 1.3.1.9 0004318,0005515,0005829,0006633,0008610,0009102,0016020,0016491,0030497,0032991,0042802,0046677,0051289,0070404,1902494 Kd=22pM IC50=430nM P0AEK4 10493822 603 GFLSGKRILVTGVASKLSIAYGIAQAMHREGAELAFTYQNDKLKGRVEEFAAQLGSDIVLQCDVAEDASIDTMFAELGKVWPKFDGFVHSIGFAPGDQLDGDYVNAVTREGFKIAHDISSYSFVAMAKACRSMLNPGSALLTLSYLGAERAIPNYNVMGLAKASLEANVRYMANAMGPEGVRVNAISAGPIRTLAASGIKDFRKMLAHCEAVTPIRRTVTIEDVGNSAAFLCSDLSAGISGEVVHVDGGFSIAAMNE 1qg6 D 1.9 BS02 TCL D 1 G93 A95 L100 Y146 Y156 A196 I200 G92 A94 L99 Y145 Y155 A195 I199 S145 Y156 M159 K163 I200 S144 Y155 M158 K162 I199 1.3.1.9 0004318,0005515,0005829,0006633,0008610,0009102,0016020,0016491,0030497,0032991,0042802,0046677,0051289,0070404,1902494 Kd=22pM IC50=430nM P0AEK4 10493822 604 GFLSGKRILVTGVASKLSIAYGIAQAMHREGAELAFTYQNDKLKGRVEEFAAQLGSDIVLQCDVAEDASIDTMFAELGKVWPKFDGFVHSIGFAPGDQLDGDYVNAVTREGFKIAHDISSYSFVAMAKACRSMLNPGSALLTLSYLGAERAIPNYNVMGLAKASLEANVRYMANAMGPEGVRVNAISAGPIRTLAASGIKDFRKMLAHCEAVTPIRRTVTIEDVGNSAAFLCSDLSAGISGEVVHVDGGFSIAAMNE 1qsg A 1.75 BS03 TCL A 1 G93 A95 Y146 Y156 A196 A197 G92 A94 Y145 Y155 A195 A196 S145 Y156 M159 K163 I200 S144 Y155 M158 K162 I199 1.3.1.9 0004318,0005515,0005829,0006633,0008610,0009102,0016020,0016491,0030497,0032991,0042802,0046677,0051289,0070404,1902494 IC50=430nM P0AEK4 10398587 1302 GFLSGKRILVTGVASKLSIAYGIAQAMHREGAELAFTYQNDKLKGRVEEFAAQLGSDIVLQCDVAEDASIDTMFAELGKVWPKFDGFVHSIGFAPGDQLDGDYVNAVTREGFKIAHDISSYSFVAMAKACRSMLNPGSALLTLSYLGAERAIPNYNVMGLAKASLEANVRYMANAMGPEGVRVNAISAGPIRTLAASGIKDFRKMLAHCEAVTPIRRTVTIEDVGNSAAFLCSDLSAGISGEVVHVDGGFSIAAMNEL 1qsg B 1.75 BS03 TCL B 1 G93 A95 L100 Y146 Y156 A196 I200 G92 A94 L99 Y145 Y155 A195 I199 S145 Y156 M159 K163 I200 S144 Y155 M158 K162 I199 1.3.1.9 0004318,0005515,0005829,0006633,0008610,0009102,0016020,0016491,0030497,0032991,0042802,0046677,0051289,0070404,1902494 IC50=430nM P0AEK4 10398587 1305 GFLSGKRILVTGVASKLSIAYGIAQAMHREGAELAFTYQNDKLKGRVEEFAAQLGSDIVLQCDVAEDASIDTMFAELGKVWPKFDGFVHSIGFAPGDQLDGDYVNAVTREGFKIAHDISSYSFVAMAKACRSMLNPGSALLTLSYLGAERAIPNYNVMGLAKASLEANVRYMANAMGPEGVRVNAISAGPIRTLAASGIKDFRKMLAHCEAVTPIRRTVTIEDVGNSAAFLCSDLSAGISGEVVHVDGGFSIAAMNEL 1qsg C 1.75 BS03 TCL C 1 G93 A95 L100 Y146 Y156 A196 I200 G92 A94 L99 Y145 Y155 A195 I199 S145 Y156 M159 K163 I200 S144 Y155 M158 K162 I199 1.3.1.9 0004318,0005515,0005829,0006633,0008610,0009102,0016020,0016491,0030497,0032991,0042802,0046677,0051289,0070404,1902494 IC50=430nM P0AEK4 10398587 1308 GFLSGKRILVTGVASKLSIAYGIAQAMHREGAELAFTYQNDKLKGRVEEFAAQLGSDIVLQCDVAEDASIDTMFAELGKVWPKFDGFVHSIGFAPGDQLDGDYVNAVTREGFKIAHDISSYSFVAMAKACRSMLNPGSALLTLSYLGAERAIPNYNVMGLAKASLEANVRYMANAMGPEGVRVNAISAGPIRTLAASGIKDFRKMLAHCEAVTPIRRTVTIEDVGNSAAFLCSDLSAGISGEVVHVDGGFSIAAMNEL 1qsg D 1.75 BS02 TCL D 1 G93 A95 L100 Y146 Y156 A196 I200 G92 A94 L99 Y145 Y155 A195 I199 S145 Y156 M159 K163 I200 S144 Y155 M158 K162 I199 1.3.1.9 0004318,0005515,0005829,0006633,0008610,0009102,0016020,0016491,0030497,0032991,0042802,0046677,0051289,0070404,1902494 IC50=430nM P0AEK4 10398587 1311 GFLSGKRILVTGVASKLSIAYGIAQAMHREGAELAFTYQNDKLKGRVEEFAAQLGSDIVLQCDVAEDASIDTMFAELGKVWPKFDGFVHSIGFAPGDQLDGDYVNAVTREGFKIAHDISSYSFVAMAKACRSMLNPGSALLTLSYLGAERAIPNYNVMGLAKASLEANVRYMANAMGPEGVRVNAISAGPIRTLAASGIKDFRKMLAHCEAVTPIRRTVTIEDVGNSAAFLCSDLSAGISGEVVHVDGGFSIAAMNEL 1qsg E 1.75 BS03 TCL E 1 G93 A95 L100 Y146 Y156 A196 I200 G92 A94 L99 Y145 Y155 A195 I199 S145 Y156 M159 K163 I200 S144 Y155 M158 K162 I199 1.3.1.9 0004318,0005515,0005829,0006633,0008610,0009102,0016020,0016491,0030497,0032991,0042802,0046677,0051289,0070404,1902494 IC50=430nM P0AEK4 10398587 1314 GFLSGKRILVTGVASKLSIAYGIAQAMHREGAELAFTYQNDKLKGRVEEFAAQLGSDIVLQCDVAEDASIDTMFAELGKVWPKFDGFVHSIGFAPGDQLDGDYVNAVTREGFKIAHDISSYSFVAMAKACRSMLNPGSALLTLSYLGAERAIPNYNVMGLAKASLEANVRYMANAMGPEGVRVNAISAGPIRTLAASGIKDFRKMLAHCEAVTPIRRTVTIEDVGNSAAFLCSDLSAGISGEVVHVDGGFSIAAMNEL 1qsg F 1.75 BS03 TCL F 1 G93 A95 Y146 Y156 A196 A197 I200 F203 G92 A94 Y145 Y155 A195 A196 I199 F202 S145 Y156 M159 K163 I200 S144 Y155 M158 K162 I199 1.3.1.9 0004318,0005515,0005829,0006633,0008610,0009102,0016020,0016491,0030497,0032991,0042802,0046677,0051289,0070404,1902494 IC50=430nM P0AEK4 10398587 1317 GFLSGKRILVTGVASKLSIAYGIAQAMHREGAELAFTYQNDKLKGRVEEFAAQLGSDIVLQCDVAEDASIDTMFAELGKVWPKFDGFVHSIGFAPGDQLDGDYVNAVTREGFKIAHDISSYSFVAMAKACRSMLNPGSALLTLSYLGAERAIPNYNVMGLAKASLEANVRYMANAMGPEGVRVNAISAGPIRTLAASGIKDFRKMLAHCEAVTPIRRTVTIEDVGNSAAFLCSDLSAGISGEVVHVDGGFSIAAMNEL 1qsg G 1.75 BS03 TCL G 1 G93 A95 Y146 Y156 A196 A197 G92 A94 Y145 Y155 A195 A196 S145 Y156 M159 K163 I200 S144 Y155 M158 K162 I199 1.3.1.9 0004318,0005515,0005829,0006633,0008610,0009102,0016020,0016491,0030497,0032991,0042802,0046677,0051289,0070404,1902494 IC50=430nM P0AEK4 10398587 1320 GFLSGKRILVTGVASKLSIAYGIAQAMHREGAELAFTYQNDKLKGRVEEFAAQLGSDIVLQCDVAEDASIDTMFAELGKVWPKFDGFVHSIGFAPGDQLDGDYVNAVTREGFKIAHDISSYSFVAMAKACRSMLNPGSALLTLSYLGAERAIPNYNVMGLAKASLEANVRYMANAMGPEGVRVNAISAGPIRTLAASGIKDFRKMLAHCEAVTPIRRTVTIEDVGNSAAFLCSDLSAGISGEVVHVDGGFSIAAMNELE 1qsg H 1.75 BS03 TCL H 1 G93 A95 L100 Y146 Y156 A196 I200 G92 A94 L99 Y145 Y155 A195 I199 S145 Y156 M159 K163 I200 S144 Y155 M158 K162 I199 1.3.1.9 0004318,0005515,0005829,0006633,0008610,0009102,0016020,0016491,0030497,0032991,0042802,0046677,0051289,0070404,1902494 IC50=430nM P0AEK4 10398587 1323 GFLSGKRILVTGVASKLSIAYGIAQAMHREGAELAFTYQNDKLKGRVEEFAAQLGSDIVLQCDVAEDASIDTMFAELGKVWPKFDGFVHSIGFAPGDQLDGDYVNAVTREGFKIAHDISSYSFVAMAKACRSMLNPGSALLTLSYLGAERAIPNYNVMGLAKASLEANVRYMANAMGPEGVRVNAISAGPIRTLAASGIKDFRKMLAHCEAVTPIRRTVTIEDVGNSAAFLCSDLSAGISGEVVHVDGGFSIAAMNEL 1uh5 A 2.2 BS01 TCL A 1 A217 N218 A219 Y267 Y277 A319 A320 I323 A122 N123 A124 Y172 Y182 A224 A225 I228 Y277 K285 Y182 K190 1.3.1.9 0004318,0006633 IC50=200nM Q9BJJ9 15381426 502 NEDICFIAGIGDTNGYGWGIAKELSKRNVKIIFGIWPPVYNIFMKNYKNGKFDNDMIIDKDKKMNILDMLPFDASFDTANDIDEETKNNKRYNMLQNYTIEDVANLIHQKYGKINMLVHSLANAKEVQKDLLNTSRKGYLDALSKSSYSLISLCKYFVNIMKPQSSIISLTYHASQKVVPGYGGGMSSAKAALESDTRVLAYHLGRNYNIRINTISAGPLKSRAATAINTFIDYAIEYSEKYAPLRQKLLSTDIGSVASFLLSRESRAITGQTIYVDNGLNIMFLPD 1uh5 B 2.2 BS01 TCL B 1 A217 N218 A219 Y267 Y277 A319 A320 A122 N123 A124 Y172 Y182 A224 A225 Y277 K285 Y182 K190 1.3.1.9 0004318,0006633 IC50=200nM Q9BJJ9 15381426 602 NEDICFIAGIGDTNGYGWGIAKELSKRNVKIIFGIWPPVYNIFMKNYKNGKFDNDMIIDKDKKMNILDMLPFDASFDTANDIDEETKNNKRYNMLQNYTIEDVANLIHQKYGKINMLVHSLANAKEVQKDLLNTSRKGYLDALSKSSYSLISLCKYFVNIMKPQSSIISLTYHASQKVVPGYGGGMSSAKAALESDTRVLAYHLGRNYNIRINTISAGPLKSRAATAINTFIDYAIEYSEKYAPLRQKLLSTDIGSVASFLLSRESRAITGQTIYVDNGLNIMFLPD 2b35 A 2.3 BS01 TCL A 1 G96 F97 M98 M103 F149 Y158 M161 P193 G95 F96 M97 M102 F148 Y157 M160 P192 Y158 K165 Y157 K164 1.3.1.9 0004318,0005504,0005886,0006633,0009274,0016491,0030497,0046677,0050343,0070403,0071768 Ki=0.22uM Ki=220nM, IC50=1000nM P9WGR1 300 TGLLDGKRILVSGIITDSSIAFHIARVAQEQGAQLVLTGFDRLRLIQRITDRLPAKAPLLELDVQNEEHLASLAGRVTEAIGAGNKLDGVVHSIGFMPQTGMGINPFFDAPYADVSKGIHISAYSYASMAKALLPIMNPGGSIVGMDFDPSRAMPAYNWMTVAKSALESVNRFVAREAGKYGVRSNLVAAGPIRTGAQIQLLEEGWDQRAPIGWNMKDATPVAKTVCALLSDWLPATTGDIIYADGGAHTQLL 2b35 B 2.3 BS01 TCL B 1 F97 M98 M103 F149 Y158 M161 P193 F96 M97 M102 F148 Y157 M160 P192 Y158 K165 Y157 K164 1.3.1.9 0004318,0005504,0005886,0006633,0009274,0016491,0030497,0046677,0050343,0070403,0071768 Ki=0.22uM Ki=220nM, IC50=1000nM P9WGR1 302 TGLLDGKRILVSGIITDSSIAFHIARVAQEQGAQLVLTGFDRLRLIQRITDRLPAKAPLLELDVQNEEHLASLAGRVTEAIGAGNKLDGVVHSIGFMPQTGMGINPFFDAPYADVSKGIHISAYSYASMAKALLPIMNPGGSIVGMDFDPSRAMPAYNWMTVAKSALESVNRFVAREAGKYGVRSNLVAAGPIRTEEGWDQRAPIGWNMKDATPVAKTVCALLSDWLPATTGDIIYADGGAHTQLL 2b35 C 2.3 BS01 TCL C 1 F97 M98 M103 F149 Y158 M161 F96 M97 M102 F148 Y157 M160 Y158 K165 Y157 K164 1.3.1.9 0004318,0005504,0005886,0006633,0009274,0016491,0030497,0046677,0050343,0070403,0071768 Ki=0.22uM Ki=220nM, IC50=1000nM P9WGR1 304 TGLLDGKRILVSGIITDSSIAFHIARVAQEQGAQLVLTGFDRLRLIQRITDRLPAKAPLLELDVQNEEHLASLAGRVTEAIGAGNKLDGVVHSIGFMPQTGMGINPFFDAPYADVSKGIHISAYSYASMAKALLPIMNPGGSIVGMDFDPSRAMPAYNWMTVAKSALESVNRFVAREAGKYGVRSNLVAAGPIRTLLEEGWDQRAPIGWNMKDATPVAKTVCALLSDWLPATTGDIIYADGGAHTQLL 2b35 D 2.3 BS01 TCL D 1 M98 M103 F149 Y158 M161 P193 A198 M199 M97 M102 F148 Y157 M160 P192 A197 M198 Y158 K165 Y157 K164 1.3.1.9 0004318,0005504,0005886,0006633,0009274,0016491,0030497,0046677,0050343,0070403,0071768 Ki=0.22uM Ki=220nM, IC50=1000nM P9WGR1 306 TGLLDGKRILVSGIITDSSIAFHIARVAQEQGAQLVLTGFDRLRLIQRITDRLPAKAPLLELDVQNEEHLASLAGRVTEAIGAGNKLDGVVHSIGFMPQTGMGINPFFDAPYADVSKGIHISAYSYASMAKALLPIMNPGGSIVGMDFDPSRAMPAYNWMTVAKSALESVNRFVAREAGKYGVRSNLVAAGPIRTLAMEGWDQRAPIGWNMKDATPVAKTVCALLSDWLPATTGDIIYADGGAHTQLL 2b35 E 2.3 BS01 TCL E 1 G96 F97 M98 M103 Y158 G95 F96 M97 M102 Y157 Y158 K165 Y157 K164 1.3.1.9 0004318,0005504,0005886,0006633,0009274,0016491,0030497,0046677,0050343,0070403,0071768 Ki=0.22uM Ki=220nM, IC50=1000nM P9WGR1 309 TGLLDGKRILVSGIITDSSIAFHIARVAQEQGAQLVLTGFDRLRLIQRITDRLPAKAPLLELDVQNEEHLASLAGRVTEAIGAGNKLDGVVHSIGFMPQTGMGINPFFDAPYADVSKGIHISAYSYASMAKALLPIMNPGGSIVGMDFDPSRAMPAYNWMTVAKSALESVNRFVAREAGKYGVRSNLVAAGPIRTAGAQIQLLEEGWDQRAPIGWNMKDATPVAKTVCALLSDWLPATTGDIIYADGGAHTQLL 2b35 F 2.3 BS01 TCL F 1 G96 M98 M103 F149 Y158 M161 G95 M97 M102 F148 Y157 M160 Y158 K165 Y157 K164 1.3.1.9 0004318,0005504,0005886,0006633,0009274,0016491,0030497,0046677,0050343,0070403,0071768 Ki=0.22uM Ki=220nM, IC50=1000nM P9WGR1 311 TGLLDGKRILVSGIITDSSIAFHIARVAQEQGAQLVLTGFDRLRLIQRITDRLPAKAPLLELDVQNEEHLASLAGRVTEAIGAGNKLDGVVHSIGFMPQTGMGINPFFDAPYADVSKGIHISAYSYASMAKALLPIMNPGGSIVGMDFDPSRAMPAYNWMTVAKSALESVNRFVAREAGKYGVRSNLVAAGPIRTQIQLLEEGWDQRAPIGWNMKDATPVAKTVCALLSDWLPATTGDIIYADGGAHTQLL 2o2s A 2.6 BS02 TCL A 1 A129 N130 Y179 Y189 A231 A126 N127 Y176 Y186 A228 Y189 K197 Y186 K194 1.3.1.9 0004318,0006633 IC50=15nM Q6UCJ9 17327670 705 PIDLRGQTAFVAGVADSHGYGWAIAKHLASAGARVALGTWPPVLGLFQKSLQSGRLDEDRKLPDGSLIEFAGVYPLDAAFDKPEDVPQDIKDNKRYAGVDGYTIKEVAVKVKQDLGNIDILVHSLANGPEVTKPLLETSRKGYLAASSNSAYSFVSLLQHFGPIMNEGGSAVTLSYLAAERVVPGYGGGMSSAKAALESDTRTLAWEAGQKYGVRVNAISAGPLKSRAASAIGKSGEKSFIDYAIDYSYNNAPLRRDLHSDDVGGAALFLLSPLARAVSGVTLYVDNGLHAMGQAVDSRSMPP 2o2s B 2.6 BS02 TCL B 1 A129 G131 Y179 Y189 M193 A231 A232 A127 G129 Y177 Y187 M191 A229 A230 Y189 K197 Y187 K195 1.3.1.9 0004318,0006633 IC50=15nM Q6UCJ9 17327670 706 FPIDLRGQTAFVAGVADSHGYGWAIAKHLASAGARVALGTWPPVLGLFQKSLQSGRLDEDRKLPDGSLIEFAGVYPLDAAFDKPEDVPQDIKDNKRYAGVDGYTIKEVAVKVKQDLGNIDILVHSLANGPEVTKPLLETSRKGYLAASSNSAYSFVSLLQHFGPIMNEGGSAVTLSYLAAERVVPGYGGGMSSAKAALESDTRTLAWEAGQKYGVRVNAISAGPLKSRAASAIGKEKSFIDYAIDYSYNNAPLRRDLHSDDVGGAALFLLSPLARAVSGVTLYVDNGLHAMGQAVDSRSMPP 2o2y A 2.2 BS02 TCL A 1 A134 N135 A136 Y184 Y194 A236 A237 A120 N121 A122 Y170 Y180 A222 A223 Y194 K202 Y180 K188 1.3.1.9 0004318,0006633 Ki=0.4nM IC50=49nM Q9BH77 17327670 705 DICFIAGIGDTNGYGWGIAKELSKRNVKIIFGIWPPVYNIFMKNYKNGKFDNDMIIDKDKKMNILDMLPFDASFDTANDIDEETKNNKRYNMLQNYTIEDVANLIHQKYGKINMLVHSLANAKEVQKDLLNTSRKGYLDALSKSSYSLISLCKYFVNIMKPQSSIISLTYHASQKVVPGYGGGMSSAKAALESDTRVLAYHLGRNYNIRINTISAGPLKSRAATAINYTFIDYAIEYSEKYAPLRQKLLSTDIGSVASFLLSRESRAITGQTIYVDNGLNIMFLPDDIYR 2o2y B 2.2 BS02 TCL B 1 A134 N135 A136 Y184 Y194 A236 A237 A120 N121 A122 Y170 Y180 A222 A223 Y194 K202 Y180 K188 1.3.1.9 0004318,0006633 Ki=0.4nM IC50=49nM Q9BH77 17327670 706 DICFIAGIGDTNGYGWGIAKELSKRNVKIIFGIWPPVYNIFMKNYKNGKFDNDMIIDKDKKMNILDMLPFDASFDTANDIDEETKNNKRYNMLQNYTIEDVANLIHQKYGKINMLVHSLANAKEVQKDLLNTSRKGYLDALSKSSYSLISLCKYFVNIMKPQSSIISLTYHASQKVVPGYGGGMSSAKAALESDTRVLAYHLGRNYNIRINTISAGPLKSRAATAINYTFIDYAIEYSEKYAPLRQKLLSTDIGSVASFLLSRESRAITGQTIYVDNGLNIMFLPDDIYR 2o2y C 2.2 BS02 TCL C 1 A134 N135 A136 Y184 Y194 M198 A236 A237 A122 N123 A124 Y172 Y182 M186 A224 A225 Y194 K202 Y182 K190 1.3.1.9 0004318,0006633 Ki=0.4nM IC50=49nM Q9BH77 17327670 708 NEDICFIAGIGDTNGYGWGIAKELSKRNVKIIFGIWPPVYNIFMKNYKNGKFDNDMIIDKDKKMNILDMLPFDASFDTANDIDEETKNNKRYNMLQNYTIEDVANLIHQKYGKINMLVHSLANAKEVQKDLLNTSRKGYLDALSKSSYSLISLCKYFVNIMKPQSSIISLTYHASQKVVPGYGGGMSSAKAALESDTRVLAYHLGRNYNIRINTISAGPLKSRAATAINYTFIDYAIEYSEKYAPLRQKLLSTDIGSVASFLLSRESRAITGQTIYVDNGLNIMFLPDDIYRN 2o2y D 2.2 BS02 TCL D 1 A134 N135 A136 Y184 Y194 A236 A237 A120 N121 A122 Y170 Y180 A222 A223 Y194 K202 Y180 K188 1.3.1.9 0004318,0006633 Ki=0.4nM IC50=49nM Q9BH77 17327670 707 DICFIAGIGDTNGYGWGIAKELSKRNVKIIFGIWPPVYNIFMKNYKNGKFDNDMIIDKDKKMNILDMLPFDASFDTANDIDEETKNNKRYNMLQNYTIEDVANLIHQKYGKINMLVHSLANAKEVQKDLLNTSRKGYLDALSKSSYSLISLCKYFVNIMKPQSSIISLTYHASQKVVPGYGGGMSSAKAALESDTRVLAYHLGRNYNIRINTISAGPLKSRAATAIYTFIDYAIEYSEKYAPLRQKLLSTDIGSVASFLLSRESRAITGQTIYVDNGLNIMFLPDDIY 2pd3 A 2.5 BS02 TCL A 1 A93 F94 A95 Y145 Y155 A195 F202 A92 F93 A94 Y144 Y154 A194 F201 Y155 K162 Y154 K161 1.3.1.9 0004318,0006633,0016491,0030497,0042802 O24990 17879346 2414 GFLKGKKGLIVGVANNKSIAYGIAQSCFNQGATLAFTYLNESLEKRVRPIAQELNSPYVYELDVSKEEHFKSLYNSVKKDLGSLDFIVHSVAFAPKEALEGSLLETSKSAFNTAMEISVYSLIELTNTLKPLLNNGASVLTLSYLGSTKYMAHYNVMGLAKAALESAVRYLAVDLGKHHIRVNALSAGPIRTLASSGIADFRMILKWNEINAPLRKNVSLEEVGNAGMYLLSSLSSGVSGEVHFVDAGYHVMGMGAVEEKDNKATLLWDLHKEQ 2pd3 B 2.5 BS02 TCL B 1 A93 A95 L100 Y145 Y155 A195 F202 A92 A94 L99 Y144 Y154 A194 F201 Y155 K162 Y154 K161 1.3.1.9 0004318,0006633,0016491,0030497,0042802 O24990 17879346 3414 GFLKGKKGLIVGVANNKSIAYGIAQSCFNQGATLAFTYLNESLEKRVRPIAQELNSPYVYELDVSKEEHFKSLYNSVKKDLGSLDFIVHSVAFAPKEALEGSLLETSKSAFNTAMEISVYSLIELTNTLKPLLNNGASVLTLSYLGSTKYMAHYNVMGLAKAALESAVRYLAVDLGKHHIRVNALSAGPIRTLASSGIADFRMILKWNEINAPLRKNVSLEEVGNAGMYLLSSLSSGVSGEVHFVDAGYHVMGMGAVEEKDNKATLLWDLHKEQ 2pd3 C 2.5 BS02 TCL C 1 A93 F94 A95 L100 Y145 Y155 A195 F202 A92 F93 A94 L99 Y144 Y154 A194 F201 Y155 K162 Y154 K161 1.3.1.9 0004318,0006633,0016491,0030497,0042802 O24990 17879346 4414 GFLKGKKGLIVGVANNKSIAYGIAQSCFNQGATLAFTYLNESLEKRVRPIAQELNSPYVYELDVSKEEHFKSLYNSVKKDLGSLDFIVHSVAFAPKEALEGSLLETSKSAFNTAMEISVYSLIELTNTLKPLLNNGASVLTLSYLGSTKYMAHYNVMGLAKAALESAVRYLAVDLGKHHIRVNALSAGPIRTLASSGIADFRMILKWNEINAPLRKNVSLEEVGNAGMYLLSSLSSGVSGEVHFVDAGYHVMGMGAVEEKDNKATLLWDLHKEQ 2pd3 D 2.5 BS02 TCL D 1 A93 A95 Y145 Y155 M158 A195 I199 F202 A92 A94 Y144 Y154 M157 A194 I198 F201 Y155 K162 Y154 K161 1.3.1.9 0004318,0006633,0016491,0030497,0042802 O24990 17879346 5414 GFLKGKKGLIVGVANNKSIAYGIAQSCFNQGATLAFTYLNESLEKRVRPIAQELNSPYVYELDVSKEEHFKSLYNSVKKDLGSLDFIVHSVAFAPKEALEGSLLETSKSAFNTAMEISVYSLIELTNTLKPLLNNGASVLTLSYLGSTKYMAHYNVMGLAKAALESAVRYLAVDLGKHHIRVNALSAGPIRTLASSGIADFRMILKWNEINAPLRKNVSLEEVGNAGMYLLSSLSSGVSGEVHFVDAGYHVMGMGAVEEKDNKATLLWDLHKEQ 2qio A 2.44 BS02 TCL A 1 A95 A97 L102 Y147 Y157 S197 A95 A97 L102 Y147 Y157 S197 S19 Y147 Y157 M160 K164 K199 S19 Y147 Y157 M160 K164 K199 1.3.1.9 0000166,0004318,0006633,0016491 ic50=3.6uM A0A6L8PBX8 18663709 601 MELLQGKTFVVMGVANQRSIAWGIARSLHNAGAKLIFTYAGERLERNVRELADTLEGQESLVLPCDVTNDEELTACFETIKQEVGTIHGVAHCIAFANRDDLKGEFVDTSRDGFLLAQNISAFSLTAVAREAKKVMTEGGNILTLTYLGGERVVKNYNVMGVAKASLEASVKYLANDLGQHGIRVNAISAGPIRTLSAKGVGDFNSILREIEERAPLRRTTTQEEVGDTAVFLFSDLARGVTGENIHVDSGYHILG 2qio B 2.44 BS02 TCL B 1 A95 A97 L102 Y147 Y157 M160 S197 A95 A97 L102 Y147 Y157 M160 S197 S19 Y147 Y157 M160 K164 K199 S19 Y147 Y157 M160 K164 K199 1.3.1.9 0000166,0004318,0006633,0016491 ic50=3.6uM A0A6L8PBX8 18663709 602 MELLQGKTFVVMGVANQRSIAWGIARSLHNAGAKLIFTYAGERLERNVRELADTLEGQESLVLPCDVTNDEELTACFETIKQEVGTIHGVAHCIAFANRDDLKGEFVDTSRDGFLLAQNISAFSLTAVAREAKKVMTEGGNILTLTYLGGERVVKNYNVMGVAKASLEASVKYLANDLGQHGIRVNAISAGPIRTLSAKGVGDFNSILREIEERAPLRRTTTQEEVGDTAVFLFSDLARGVTGENIHVDSGYHILG 2qio C 2.44 BS02 TCL C 1 A95 F96 A97 L102 Y147 Y157 S197 A198 A95 F96 A97 L102 Y147 Y157 S197 A198 S19 Y147 Y157 M160 K164 K199 S19 Y147 Y157 M160 K164 K199 1.3.1.9 0000166,0004318,0006633,0016491 ic50=3.6uM A0A6L8PBX8 18663709 603 MELLQGKTFVVMGVANQRSIAWGIARSLHNAGAKLIFTYAGERLERNVRELADTLEGQESLVLPCDVTNDEELTACFETIKQEVGTIHGVAHCIAFANRDDLKGEFVDTSRDGFLLAQNISAFSLTAVAREAKKVMTEGGNILTLTYLGGERVVKNYNVMGVAKASLEASVKYLANDLGQHGIRVNAISAGPIRTLSAKGVGDFNSILREIEERAPLRRTTTQEEVGDTAVFLFSDLARGVTGENIHVDSGYHILG 2qio D 2.44 BS02 TCL D 1 A95 A97 L102 Y147 Y157 M160 S197 V201 A95 A97 L102 Y147 Y157 M160 S197 V201 S19 Y147 Y157 M160 K164 K199 S19 Y147 Y157 M160 K164 K199 1.3.1.9 0000166,0004318,0006633,0016491 ic50=3.6uM A0A6L8PBX8 18663709 604 MELLQGKTFVVMGVANQRSIAWGIARSLHNAGAKLIFTYAGERLERNVRELADTLEGQESLVLPCDVTNDEELTACFETIKQEVGTIHGVAHCIAFANRDDLKGEFVDTSRDGFLLAQNISAFSLTAVAREAKKVMTEGGNILTLTYLGGERVVKNYNVMGVAKASLEASVKYLANDLGQHGIRVNAISAGPIRTLSAKGVGDFNSILREIEERAPLRRTTTQEEVGDTAVFLFSDLARGVTGENIHVDSGYHILG 2wyw A 1.9 BS02 TCL A 1 A95 A97 Y147 Y157 A197 I201 F204 A95 A97 Y147 Y157 A197 I201 F204 S21 Y147 Y157 M160 K164 S21 Y147 Y157 M160 K164 1.3.1.9 0000166,0004318,0006633,0016491 Q5SLI9 23027736 1261 MLTVDLSGKKALVMGVTNQRSLGFAIAAKLKEAGAEVALSYQAERLRPEAEKLAEALGGALLFRADVTQDEELDALFAGVKEAFGGLDYLVHAIAFAPREAMEGRYIDTRRQDWLLALEVSAYSLVAVARRAEPLLREGGGIVTLTYYASEKVVPKYNVMAIAKAALEASVRYLAYELGPKGVRVNAISAGPVRTVAARSIPGFTKMYDRVAQTAPLRRNITQEEVGNLGLFLLSPLASGITGEVVYVDAGYHIMGMEL 2wyw B 1.9 BS02 TCL B 1 A95 A97 Y157 A197 I201 A95 A97 Y157 A197 I201 S21 Y147 Y157 M160 K164 S21 Y147 Y157 M160 K164 1.3.1.9 0000166,0004318,0006633,0016491 Q5SLI9 23027736 1260 MLTVDLSGKKALVMGVTNQRSLGFAIAAKLKEAGAEVALSYQAERLRPEAEKLAEALGGALLFRADVTQDEELDALFAGVKEAFGGLDYLVHAIAFAPREAMEGRYIDTRRQDWLLALEVSAYSLVAVARRAEPLLREGGGIVTLTYYASEKVVPKYNVMAIAKAALEASVRYLAYELGPKGVRVNAISAGPVRTVAARSIPGFTKMYDRVAQTAPLRRNITQEEVGNLGLFLLSPLASGITGEVVYVDAGYHIMGME 2wyw C 1.9 BS02 TCL C 1 A95 A97 Y147 Y157 A197 S200 I201 A95 A97 Y147 Y157 A197 S200 I201 S21 Y147 Y157 M160 K164 S21 Y147 Y157 M160 K164 1.3.1.9 0000166,0004318,0006633,0016491 Q5SLI9 23027736 1260 MLTVDLSGKKALVMGVTNQRSLGFAIAAKLKEAGAEVALSYQAERLRPEAEKLAEALGGALLFRADVTQDEELDALFAGVKEAFGGLDYLVHAIAFAPREAMEGRYIDTRRQDWLLALEVSAYSLVAVARRAEPLLREGGGIVTLTYYASEKVVPKYNVMAIAKAALEASVRYLAYELGPKGVRVNAISAGPVRTVAARSIPGFTKMYDRVAQTAPLRRNITQEEVGNLGLFLLSPLASGITGEVVYVDAGYHIMGME 2wyw D 1.9 BS02 TCL D 1 A95 A97 Y147 Y157 A197 A198 S200 I201 A95 A97 Y147 Y157 A197 A198 S200 I201 S21 Y147 Y157 M160 K164 S21 Y147 Y157 M160 K164 1.3.1.9 0000166,0004318,0006633,0016491 Q5SLI9 23027736 1260 MLTVDLSGKKALVMGVTNQRSLGFAIAAKLKEAGAEVALSYQAERLRPEAEKLAEALGGALLFRADVTQDEELDALFAGVKEAFGGLDYLVHAIAFAPREAMEGRYIDTRRQDWLLALEVSAYSLVAVARRAEPLLREGGGIVTLTYYASEKVVPKYNVMAIAKAALEASVRYLAYELGPKGVRVNAISAGPVRTVAARSIPGFTKMYDRVAQTAPLRRNITQEEVGNLGLFLLSPLASGITGEVVYVDAGYHIMGME 3am3 A 2.5 BS02 TCL A 1 A217 A219 V222 Y267 Y277 A319 A320 I323 A122 A124 V127 Y172 Y182 A224 A225 I228 Y277 K285 Y182 K190 1.3.1.9 0004318,0006633 Ki=28nM IC50=200nM Q9BJJ9 21280175 802 NEDICFIAGIGDTNGYGWGIAKELSKRNVKIIFGIWPPVYNIFMKNYKNGKFDNDMIIDKDKKMNILDMLPFDASFDTANDIDEETKNNKRYNMLQNYTIEDVANLIHQKYGKINMLVHSLANAKEVQKDLLNTSRKGYLDALSKSSYSLISLCKYFVNIMKPQSSIISLTYHASQKVVPGYGGGMSSAKAALESDTRVLAYHLGRNYNIRINTISAGPLKSRAATAINTFIDYMIEYSEKYAPLRQKLLSTDIGSVASFLLSRESRAITGQTIYVDNGLNIMFLPD 3am3 B 2.5 BS02 TCL B 1 A217 N218 A219 V222 Y267 Y277 M281 A319 A320 I323 A122 N123 A124 V127 Y172 Y182 M186 A224 A225 I228 Y277 K285 Y182 K190 1.3.1.9 0004318,0006633 Ki=28nM IC50=200nM Q9BJJ9 21280175 902 NEDICFIAGIGDTNGYGWGIAKELSKRNVKIIFGIWPPVYNIFMKNYKNGKFDNDMIIDKDKKMNILDMLPFDASFDTANDIDEETKNNKRYNMLQNYTIEDVANLIHQKYGKINMLVHSLANAKEVQKDLLNTSRKGYLDALSKSSYSLISLCKYFVNIMKPQSSIISLTYHASQKVVPGYGGGMSSAKAALESDTRVLAYHLGRNYNIRINTISAGPLKSRAATAINTFIDYMIEYSEKYAPLRQKLLSTDIGSVASFLLSRESRAITGQTIYVDNGLNIMFLPD 3am5 A 2.05 BS02 TCL A 1 A217 N218 A219 Y267 Y277 A319 A320 I323 I369 A121 N122 A123 Y171 Y181 A223 A224 I227 I231 Y277 K285 Y181 K189 1.3.1.9 0004318,0006633 Ki=38nM IC50=200nM Q9BJJ9 21280175 802 EDICFIAGIGDTNGYGWGIAKELSKRNVKIIFGIWPPVYNIFMKNYKNGKFDNDMIIDKDKKMNILDMLPFDASFDTANDIDEETKNNKRYNMLQNYTIEDVANLIHQKYGKINMLVHSLANAKEVQKDLLNTSRKGYLDALSKSSYSLISLCKYFVNIMKPQSSIISLTYHASQKVVPGYGGGMSSAKAALESDTRVLAYHLGRNYNIRINTISAGPLASRAATAINTFIDYAIEYSEKYAPLRQKLLSTDIGSVASFLLSRESRAITGQTIYVDNGLNIMFLPD 3am5 B 2.05 BS02 TCL B 1 A217 A219 Y267 Y277 A319 A320 I323 I369 A122 A124 Y172 Y182 A224 A225 I228 I233 Y277 K285 Y182 K190 1.3.1.9 0004318,0006633 Ki=38nM IC50=200nM Q9BJJ9 21280175 902 NEDICFIAGIGDTNGYGWGIAKELSKRNVKIIFGIWPPVYNIFMKNYKNGKFDNDMIIDKDKKMNILDMLPFDASFDTANDIDEETKNNKRYNMLQNYTIEDVANLIHQKYGKINMLVHSLANAKEVQKDLLNTSRKGYLDALSKSSYSLISLCKYFVNIMKPQSSIISLTYHASQKVVPGYGGGMSSAKAALESDTRVLAYHLGRNYNIRINTISAGPLASRAATAINYTFIDYAIEYSEKYAPLRQKLLSTDIGSVASFLLSRESRAITGQTIYVDNGLNIMFLPD 3f4b A 2.49 BS02 TCL A 1 A202 N203 G204 Y252 Y262 A305 I308 A118 N119 G120 Y168 Y178 A221 I224 Y262 K270 Y178 K186 1.3.1.9 0004318,0006633 Q6TEI5 19064257 400 NEICFIAGVGDSNGYGWGIAKELSKRNVKVIFGVWPPVYNIFIKNLESGKFDKDMIIKRMQILDVLPLDAGFDNYDDIDEDTKNNKRYNNLKNYSIEEVANLIYNKYGKISMLVHSLANGREVQKSLLDTSRDGYLDAISKSSYSLISLCKHFCKFMNSGGSVVSLTYQASQKVVPGYGGGMSSAKAALESDTRVLAYYLGRKYNIRINTISAGPLKSRAATAINSFIDYAIDYSEKYAPLKKKLLSTDVGSVASFLLSKESSAVTGQTIYVDNGLNIMFGPDD 3f4b B 2.49 BS02 TCL B 1 A202 G204 V207 Y252 Y262 A304 A305 A123 G125 V128 Y173 Y183 A225 A226 Y262 K270 Y183 K191 1.3.1.9 0004318,0006633 Q6TEI5 19064257 500 NEICFIAGVGDSNGYGWGIAKELSKRNVKVIFGVWPPVYNIFIKNLESGKFDKDMIINNDNSKRMQILDVLPLDAGFDNYDDIDEDTKNNKRYNNLKNYSIEEVANLIYNKYGKISMLVHSLANGREVQKSLLDTSRDGYLDAISKSSYSLISLCKHFCKFMNSGGSVVSLTYQASQKVVPGYGGGMSSAKAALESDTRVLAYYLGRKYNIRINTISAGPLKSRAATAIYSFIDYAIDYSEKYAPLKKKLLSTDVGSVASFLLSKESSAVTGQTIYVDNGLNIMFGPDD 3f4b C 2.49 BS02 TCL C 1 A202 N203 G204 Y252 Y262 A305 A117 N118 G119 Y167 Y177 A220 Y262 K270 Y177 K185 1.3.1.9 0004318,0006633 Q6TEI5 19064257 400 NEICFIAGVGDSNGYGWGIAKELSKRNVKVIFGVWPPVYNIFIKNLESGKFDKDMIIRMQILDVLPLDAGFDNYDDIDEDTKNNKRYNNLKNYSIEEVANLIYNKYGKISMLVHSLANGREVQKSLLDTSRDGYLDAISKSSYSLISLCKHFCKFMNSGGSVVSLTYQASQKVVPGYGGGMSSAKAALESDTRVLAYYLGRKYNIRINTISAGPLKSRAATAISFIDYAIDYSEKYAPLKKKLLSTDVGSVASFLLSKESSAVTGQTIYVDNGLNIMFGPDD 3f4b D 2.49 BS02 TCL D 1 A202 N203 G204 V207 Y252 Y262 A304 F332 A123 N124 G125 V128 Y173 Y183 A225 F232 Y262 K270 Y183 K191 1.3.1.9 0004318,0006633 Q6TEI5 19064257 500 NEICFIAGVGDSNGYGWGIAKELSKRNVKVIFGVWPPVYNIFIKNLESGKFDKDMIINNDNSKRMQILDVLPLDAGFDNYDDIDEDTKNNKRYNNLKNYSIEEVANLIYNKYGKISMLVHSLANGREVQKSLLDTSRDGYLDAISKSSYSLISLCKHFCKFMNSGGSVVSLTYQASQKVVPGYGGGMSSAKAALESDTRVLAYYLGRKYNIRINTISAGPLKSRAATAIYSFIDYAIDYSEKYAPLKKKLLSTDVGSVASFLLSKESSAVTGQTIYVDNGLNIMFGPDD 3gr6 A 2.28 BS02 TCL A 1 A97 Y147 Y157 M160 S197 A198 V201 F204 A96 Y146 Y156 M159 S196 A197 V200 F203 Y147 Y157 M160 K164 K199 Y146 Y156 M159 K163 K198 1.3.1.39 0000166,0004318,0006633,0016491,0030497,0042802,0050661,0141148 Kd=2.92nM IC50=70nM, Ki=0.05nM Q6GI75 19768684 371 LNLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEAHLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDISSYSLTIVAHEAKKLMPEGGSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGPDNIRVNAISAGPIRTLSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSGVTGENIHVDSGFHAIK 3gr6 D 2.28 BS02 TCL D 1 F96 A97 Y147 Y157 M160 S197 V201 F100 A101 Y151 Y161 M164 S201 V205 Y147 Y157 M160 K164 K199 Y151 Y161 M164 K168 K203 1.3.1.39 0000166,0004318,0006633,0016491,0030497,0042802,0050661,0141148 Kd=2.92nM IC50=70nM, Ki=0.05nM Q6GI75 19768684 258 LAAAMLNLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEAHLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDISSYSLTIVAHEAKKLMPEGGSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGPDNIRVNAISAGPIRTLSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSGVTGENIHVDSGFHAIK 3gr6 G 2.28 BS02 TCL G 1 A95 F96 A97 Y147 Y157 M160 S197 A198 V201 F204 A93 F94 A95 Y145 Y155 M158 S195 A196 V199 F202 1.3.1.39 0000166,0004318,0006633,0016491,0030497,0042802,0050661,0141148 Kd=2.92nM IC50=70nM, Ki=0.05nM Q6GI75 19768684 258 NLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEAHLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDISSYSLTIVAHEAKKLMPEGGSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGPDNIRVNAISAGPIRTLSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSGVTGENIHVDSGFHAIK 3gr6 J 2.28 BS02 TCL J 1 A97 Y147 Y157 M160 S197 A198 V201 F204 A101 Y151 Y161 M164 S201 A202 V205 F208 1.3.1.39 0000166,0004318,0006633,0016491,0030497,0042802,0050661,0141148 Kd=2.92nM IC50=70nM, Ki=0.05nM Q6GI75 19768684 258 LAAAMLNLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEAHLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDISSYSLTIVAHEAKKLMPEGGSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGPDNIRVNAISAGPIRTLSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSGVTGENIHVDSGFHAIK 3nrc A 2.101 BS02 TCL A 1 A92 A94 L99 Y146 Y156 A196 I200 F203 A91 A93 L98 Y145 Y155 A195 I199 F202 M28 A33 C51 N55 P56 A57 D117 T145 Y156 M159 K163 T194 M27 A32 C50 N54 P55 A56 D116 T144 Y155 M158 K162 T193 1.3.1.9 0000166,0004318,0006633,0016491 IC50=1300nM Q5NGQ3 21045289 262 GFLAGKKILITGLLSNKSIAYGIAKAMHREGAELAFTYVGQFKDRVEKLCAEFNPAAVLPCDVISDQEIKDLFVELGKVWDGLDAIVHSIAFAPRDQLEGNFIDCVTREGFSIAHDISAYSFAALAKEGRSMMKNRNASMVALTYIGAEKAMPSYNTMGVAKASLEATVRYTALALGEDGIKVNAVSAGPIKTLAASGISNFKKMLDYNAMVSPLKKNVDIMEVGNTVAFLCSDMATGITGEVVHVDAGYHCVSMG 3nrc B 2.101 BS02 TCL B 1 A92 A94 L99 Y146 Y156 A196 I200 F203 A91 A93 L98 Y145 Y155 A195 I199 F202 M28 A33 C51 N55 P56 A57 D117 T145 Y156 M159 K163 T194 M27 A32 C50 N54 P55 A56 D116 T144 Y155 M158 K162 T193 1.3.1.9 0000166,0004318,0006633,0016491 IC50=1300nM Q5NGQ3 21045289 262 GFLAGKKILITGLLSNKSIAYGIAKAMHREGAELAFTYVGQFKDRVEKLCAEFNPAAVLPCDVISDQEIKDLFVELGKVWDGLDAIVHSIAFAPRDQLEGNFIDCVTREGFSIAHDISAYSFAALAKEGRSMMKNRNASMVALTYIGAEKAMPSYNTMGVAKASLEATVRYTALALGEDGIKVNAVSAGPIKTLAASGISNFKKMLDYNAMVSPLKKNVDIMEVGNTVAFLCSDMATGITGEVVHVDAGYHCVSMG 3oid A 1.8 BS01 TCL A 1 S92 G93 Y151 A191 H194 F195 S90 G91 Y149 A189 H192 F193 G15 S141 Y151 V154 K158 G13 S139 Y149 V152 K156 1.3.1.104 0004318,0006633,0016491,0016616,0030497,0050661,0141148 P71079 21185310 601 QNKCALVTGSSRGVGKAAAIRLAENGYNIVINYARSKKAALETAEEIEKLGVKVLVVKANVGQPAKIKEMFQQIDETFGRLDVFVNNAASGVLRPVMELEETHWDWTMNINAKALLFCAQEAAKLMEKNGGGHIVSISSLGSIRYLENYTTVGVSKAALEALTRYLAVELSPKQIIVNAVSGGAIDTDALKHFPNREDLLEDARQNTPAGRMVEIKDMVDTVEFLVSSKADMIRGQTIIVDGGRSLLVL 3oid B 1.8 BS01 TCL B 1 S92 G93 Y151 A191 H194 F195 S92 G93 Y151 A191 H194 F195 G15 S141 Y151 V154 K158 G15 S141 Y151 V154 K158 1.3.1.104 0004318,0006633,0016491,0016616,0030497,0050661,0141148 P71079 21185310 603 MEQNKCALVTGSSRGVGKAAAIRLAENGYNIVINYARSKKAALETAEEIEKLGVKVLVVKANVGQPAKIKEMFQQIDETFGRLDVFVNNAASGVLRPVMELEETHWDWTMNINAKALLFCAQEAAKLMEKNGGGHIVSISSLGSIRYLENYTTVGVSKAALEALTRYLAVELSPKQIIVNAVSGGAIDTDALKHFPNREDLLEDARQNTPAGRMVEIKDMVDTVEFLVSSKADMIRGQTIIVDGGRSLLVL 3oid C 1.8 BS01 TCL C 1 A91 G93 Y151 A191 H194 F195 A88 G90 Y148 A188 H191 F192 G15 S141 Y151 V154 K158 G12 S138 Y148 V151 K155 1.3.1.104 0004318,0006633,0016491,0016616,0030497,0050661,0141148 P71079 21185310 604 NKCALVTGSSRGVGKAAAIRLAENGYNIVINYARSKKAALETAEEIEKLGVKVLVVKANVGQPAKIKEMFQQIDETFGRLDVFVNNAASGVLRPVMELEETHWDWTMNINAKALLFCAQEAAKLMEKNGGGHIVSISSLGSIRYLENYTTVGVSKAALEALTRYLAVELSPKQIIVNAVSGGAIDTDALKHFPNREDLLEDARQNTPAGRMVEIKDMVDTVEFLVSSKADMIRGQTIIVDGGRSLLVL 3oid D 1.8 BS01 TCL D 1 A91 S92 G93 Y151 A191 H194 F195 A88 S89 G90 Y148 A188 H191 F192 G15 S141 Y151 V154 K158 G12 S138 Y148 V151 K155 1.3.1.104 0004318,0006633,0016491,0016616,0030497,0050661,0141148 P71079 21185310 602 NKCALVTGSSRGVGKAAAIRLAENGYNIVINYARSKKAALETAEEIEKLGVKVLVVKANVGQPAKIKEMFQQIDETFGRLDVFVNNAASGVLRPVMELEETHWDWTMNINAKALLFCAQEAAKLMEKNGGGHIVSISSLGSIRYLENYTTVGVSKAALEALTRYLAVELSPKQIIVNAVSGGAIDTDALKHFPNREDLLEDARQNTPAGRMVEIKDMVDTVEFLVSSKADMIRGQTIIVDGGRSLLVL 3oif A 2.6 BS02 TCL A 1 A96 A98 L103 Y148 Y158 M161 S198 I202 A96 A98 L103 Y148 Y158 M161 S198 I202 Y148 Y158 M161 K165 K200 Y148 Y158 M161 K165 K200 1.3.1.9 0004318,0006633,0016491,0030497,0070417 IC50=500nM P54616 21185310 502 MNFSLEGRNIVVMGVANKRSIAWGIARSLHEAGARLIFTYAGERLEKSVHELAGTLDRNDSIILPCDVTNDAEIETCFASIKEQVGVIHGIAHCIAFANKEELVGEYLNTNRDGFLLAHNISSYSLTAVVKAARPMMTEGGSIVTLTYLGGELVMPNYNVMGVAKASLDASVKYLAADLGKENIRVNSISAGPIRTLSAKGISDFNSILKDIEERAPLRRTTTPEEVGDTAAFLFSDMSRGITGENLHVDSGFHITAR 3oif D 2.6 BS02 TCL D 1 A96 A98 Y148 Y158 S198 A96 A98 Y148 Y158 S198 Y148 Y158 M161 K165 K200 Y148 Y158 M161 K165 K200 1.3.1.9 0004318,0006633,0016491,0030497,0070417 IC50=500nM P54616 21185310 602 MNFSLEGRNIVVMGVANKRSIAWGIARSLHEAGARLIFTYAGERLEKSVHELAGTLDRNDSIILPCDVTNDAEIETCFASIKEQVGVIHGIAHCIAFANKEELVGEYLNTNRDGFLLAHNISSYSLTAVVKAARPMMTEGGSIVTLTYLGGELVMPNYNVMGVAKASLDASVKYLAADLGKENIRVNSISAGPIRTLSAKGSDFNSILKDIEERAPLRRTTTPEEVGDTAAFLFSDMSRGITGENLHVDSGFHITAR 3p9t A 2.02 BS01 TCL A 1 H67 F70 M93 L114 G132 F133 A136 M140 H167 V170 H62 F65 M88 L109 G127 F128 A131 M135 H162 V165 ? 0000976,0003677,0003700,0006355 Kd=0.63uM -logKd/Ki=6.20, Kd=0.63uM Q8KLP4 21738470 221 KEDTQATREGILDAAEACFHEHGVARTTLEMIGARAGYTRGAVYWHFKNKSEVLAAIVERVHLPFMQELERTSTDQRDTPVHDLRAVMIHSFIELSEDERLRKTMEIMLRSDASANTRVLTEMQQAGFRDALDRMERALRRARDLGQLREGADPKIAARMLHATVLGVLHGAMVEPELMDLKRDGMLALDMTLAAYVKDGVFVPGTVPEPLPE 3p9t A 2.02 BS02 TCL A 2 H67 F70 L100 M113 H62 F65 L95 M108 ? 0000976,0003677,0003700,0006355 Kd=0.63uM -logKd/Ki=6.20, Kd=0.63uM Q8KLP4 21738470 222 KEDTQATREGILDAAEACFHEHGVARTTLEMIGARAGYTRGAVYWHFKNKSEVLAAIVERVHLPFMQELERTSTDQRDTPVHDLRAVMIHSFIELSEDERLRKTMEIMLRSDASANTRVLTEMQQAGFRDALDRMERALRRARDLGQLREGADPKIAARMLHATVLGVLHGAMVEPELMDLKRDGMLALDMTLAAYVKDGVFVPGTVPEPLPE 3pjd A 2.5 BS02 TCL A 1 A93 F94 A95 L100 Y146 Y156 A196 I200 F203 A92 F93 A94 L99 Y145 Y155 A195 I199 F202 S145 Y156 M159 K163 I200 S144 Y155 M158 K162 I199 1.3.1.9 0004318,0005515,0005829,0006633,0008610,0009102,0016020,0016491,0030497,0032991,0042802,0046677,0051289,0070404,1902494 ic50=380nM IC50=430nM P0AEK4 21094257 801 GFLSGKRILVTGVASKLSIAYGIAQAMHREGAELAFTYQNDKLKGRVEEFAAQLGSDIVLQCDVAEDASIDTMFAELGKVWPKFDGFVHSIAFAPGDQLDGDYVNAVTREGFKIAHDISSYSFVAMAKACRSMLNPGSALLTLSYLGAERAIPNYNVMGLAKASLEANVRYMANAMGPEGVRVNAISAGPIRTLAASGIKDFRKMLAHCEAVTPIRRTVTIEDVGNSAAFLCSDLSAGISGEVVHVDGGFSIAAMNE 3pjd B 2.5 BS02 TCL B 1 A93 F94 A95 Y146 Y156 M159 A196 A197 I200 A92 F93 A94 Y145 Y155 M158 A195 A196 I199 S145 Y156 M159 K163 I200 S144 Y155 M158 K162 I199 1.3.1.9 0004318,0005515,0005829,0006633,0008610,0009102,0016020,0016491,0030497,0032991,0042802,0046677,0051289,0070404,1902494 ic50=380nM IC50=430nM P0AEK4 21094257 802 GFLSGKRILVTGVASKLSIAYGIAQAMHREGAELAFTYQNDKLKGRVEEFAAQLGSDIVLQCDVAEDASIDTMFAELGKVWPKFDGFVHSIAFAPGDQLDGDYVNAVTREGFKIAHDISSYSFVAMAKACRSMLNPGSALLTLSYLGAERAIPNYNVMGLAKASLEANVRYMANAMGPEGVRVNAISAGPIRTLAASGIKDFRKMLAHCEAVTPIRRTVTIEDVGNSAAFLCSDLSAGISGEVVHVDGGFSIAAMNE 3pje A 2.5 BS02 TCL A 1 S93 F94 A95 L100 Y146 Y156 A196 I200 F203 S92 F93 A94 L99 Y145 Y155 A195 I199 F202 S145 Y156 M159 K163 I200 S144 Y155 M158 K162 I199 1.3.1.9 0004318,0005515,0005829,0006633,0008610,0009102,0016020,0016491,0030497,0032991,0042802,0046677,0051289,0070404,1902494 ic50=470nM IC50=430nM P0AEK4 21094257 801 GFLSGKRILVTGVASKLSIAYGIAQAMHREGAELAFTYQNDKLKGRVEEFAAQLGSDIVLQCDVAEDASIDTMFAELGKVWPKFDGFVHSISFAPGDQLDGDYVNAVTREGFKIAHDISSYSFVAMAKACRSMLNPGSALLTLSYLGAERAIPNYNVMGLAKASLEANVRYMANAMGPEGVRVNAISAGPIRTLAASGIKDFRKMLAHCEAVTPIRRTVTIEDVGNSAAFLCSDLSAGISGEVVHVDGGFSIAAMNE 3pje B 2.5 BS02 TCL B 1 S93 A95 Y146 Y156 A196 F203 S92 A94 Y145 Y155 A195 F202 S145 Y156 M159 K163 I200 S144 Y155 M158 K162 I199 1.3.1.9 0004318,0005515,0005829,0006633,0008610,0009102,0016020,0016491,0030497,0032991,0042802,0046677,0051289,0070404,1902494 ic50=470nM IC50=430nM P0AEK4 21094257 802 GFLSGKRILVTGVASKLSIAYGIAQAMHREGAELAFTYQNDKLKGRVEEFAAQLGSDIVLQCDVAEDASIDTMFAELGKVWPKFDGFVHSISFAPGDQLDGDYVNAVTREGFKIAHDISSYSFVAMAKACRSMLNPGSALLTLSYLGAERAIPNYNVMGLAKASLEANVRYMANAMGPEGVRVNAISAGPIRTLAASGIKDFRKMLAHCEAVTPIRRTVTIEDVGNSAAFLCSDLSAGISGEVVHVDGGFSIAAMNE 3pjf A 1.9 BS02 TCL A 1 V93 A95 L100 Y146 Y156 V92 A94 L99 Y145 Y155 S145 Y156 M159 K163 S144 Y155 M158 K162 1.3.1.9 0004318,0005515,0005829,0006633,0008610,0009102,0016020,0016491,0030497,0032991,0042802,0046677,0051289,0070404,1902494 ic50=68500nM IC50=430nM P0AEK4 21094257 502 GFLSGKRILVTGVASKLSIAYGIAQAMHREGAELAFTYQNDKLKGRVEEFAAQLGSDIVLQCDVAEDASIDTMFAELGKVWPKFDGFVHSIVFAPGDQLDGDYVNAVTREGFKIAHDISSYSFVAMAKACRSMLNPGSALLTLSYLGAERAIPNYNVMGLAKASLEANVRYMANAMGPEGVRVNAISAGPIRTKMLAHCEAVTPIRRTVTIEDVGNSAAFLCSDLSAGISGEVVHVDGGFSIAAMNE 3pjf B 1.9 BS02 TCL B 1 V93 A95 L100 Y146 Y156 V92 A94 L99 Y145 Y155 S145 Y156 M159 K163 I200 S144 Y155 M158 K162 I199 1.3.1.9 0004318,0005515,0005829,0006633,0008610,0009102,0016020,0016491,0030497,0032991,0042802,0046677,0051289,0070404,1902494 ic50=68500nM IC50=430nM P0AEK4 21094257 504 GFLSGKRILVTGVASKLSIAYGIAQAMHREGAELAFTYQNDKLKGRVEEFAAQLGSDIVLQCDVAEDASIDTMFAELGKVWPKFDGFVHSIVFAPGDQLDGDYVNAVTREGFKIAHDISSYSFVAMAKACRSMLNPGSALLTLSYLGAERAIPNYNVMGLAKASLEANVRYMANAMGPEGVRVNAISAGPIRTLAASGIKDFRKMLAHCEAVTPIRRTVTIEDVGNSAAFLCSDLSAGISGEVVHVDGGFSIAAMNE 4ali A 2.1 BS02 TCL A 1 A95 F96 A97 Y147 Y157 M160 S197 V201 F204 A93 F94 A95 Y145 Y155 M158 S195 V199 F202 Y147 Y157 M160 K164 K199 Y145 Y155 M158 K162 K197 1.3.1.39 0000166,0004318,0006633,0016491,0042802,0141148 A0A0H3JLH9 22579249 1258 NLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEAHLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDISSYSLTIVAHEAKKLMPEGGSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGPDNIRVNAISAGPIRTLSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSGVTGENIHVDSGFHAIK 4ali B 2.1 BS01 TCL B 1 A95 A97 Y147 Y157 M160 S197 A94 A96 Y146 Y156 M159 S196 Y147 Y157 M160 K164 K199 Y146 Y156 M159 K163 K198 1.3.1.39 0000166,0004318,0006633,0016491,0042802,0141148 A0A0H3JLH9 22579249 1257 VNLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEAHLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDISSYSLTIVAHEAKKLMPEGGSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGPDNIRVNAISAGPIRTLSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSGVTGENIHVDSGFHAIK 4ali C 2.1 BS02 TCL C 1 A95 A97 L102 Y147 Y157 M160 S197 A198 F204 A94 A96 L101 Y146 Y156 M159 S196 A197 F203 Y147 Y157 M160 K164 K199 Y146 Y156 M159 K163 K198 1.3.1.39 0000166,0004318,0006633,0016491,0042802,0141148 A0A0H3JLH9 22579249 1258 VNLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEAHLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDISSYSLTIVAHEAKKLMPEGGSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGPDNIRVNAISAGPIRTLSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSGVTGENIHVDSGFHAIK 4ali D 2.1 BS02 TCL D 1 A95 F96 A97 Y147 Y157 S197 V201 A93 F94 A95 Y145 Y155 S195 V199 Y147 Y157 M160 K164 K199 Y145 Y155 M158 K162 K197 1.3.1.39 0000166,0004318,0006633,0016491,0042802,0141148 A0A0H3JLH9 22579249 1258 NLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEAHLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDISSYSLTIVAHEAKKLMPEGGSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGPDNIRVNAISAGPIRTLSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSGVTGENIHVDSGFHAIK 4ali E 2.1 BS02 TCL E 1 A95 A97 Y147 Y157 S197 A198 V201 F204 A94 A96 Y146 Y156 S196 A197 V200 F203 Y147 Y157 M160 K164 K199 Y146 Y156 M159 K163 K198 1.3.1.39 0000166,0004318,0006633,0016491,0042802,0141148 A0A0H3JLH9 22579249 1258 VNLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEAHLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDISSYSLTIVAHEAKKLMPEGGSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGPDNIRVNAISAGPIRTLSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSGVTGENIHVDSGFHAIK 4ali F 2.1 BS02 TCL F 1 A95 A97 Y147 Y157 M160 S197 A198 V201 F204 A94 A96 Y146 Y156 M159 S196 A197 V200 F203 Y147 Y157 M160 K164 K199 Y146 Y156 M159 K163 K198 1.3.1.39 0000166,0004318,0006633,0016491,0042802,0141148 A0A0H3JLH9 22579249 1258 VNLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEAHLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDISSYSLTIVAHEAKKLMPEGGSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGPDNIRVNAISAGPIRTLSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSGVTGENIHVDSGFHAIK 4ali G 2.1 BS02 TCL G 1 A95 A97 Y147 Y157 M160 S197 A198 V201 A94 A96 Y146 Y156 M159 S196 A197 V200 Y147 Y157 M160 K164 K199 Y146 Y156 M159 K163 K198 1.3.1.39 0000166,0004318,0006633,0016491,0042802,0141148 A0A0H3JLH9 22579249 1258 VNLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEAHLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDISSYSLTIVAHEAKKLMPEGGSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGPDNIRVNAISAGPIRTLSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSGVTGENIHVDSGFHAIK 4ali H 2.1 BS02 TCL H 1 A95 F96 A97 Y147 Y157 M160 S197 V201 A94 F95 A96 Y146 Y156 M159 S196 V200 Y147 Y157 M160 K164 K199 Y146 Y156 M159 K163 K198 1.3.1.39 0000166,0004318,0006633,0016491,0042802,0141148 A0A0H3JLH9 22579249 1258 VNLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEAHLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDISSYSLTIVAHEAKKLMPEGGSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGPDNIRVNAISAGPIRTLSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSGVTGENIHVDSGFHAIK 4all A 2.8 BS01 TCL A 1 A95 F96 A97 Y147 Y157 M160 S197 A95 F96 A97 Y147 Y157 M160 S197 Y147 Y157 M160 K164 K199 Y147 Y157 M160 K164 K199 1.3.1.39 0000166,0004318,0006633,0016491,0042802,0141148 A0A0H3JLH9 22579249 1257 MLNLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEAHLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDISSYSLTIVAHEAKKLMPEGGSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGPDNIRVNAISAGPIRTLSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSGVTGENIHVDSGFHAIK 4all B 2.8 BS02 TCL B 1 A97 Y147 Y157 M160 S197 A95 Y145 Y155 M158 S195 Y147 Y157 M160 K164 K199 Y145 Y155 M158 K162 K197 1.3.1.39 0000166,0004318,0006633,0016491,0042802,0141148 A0A0H3JLH9 22579249 1258 NLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEAHLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDISSYSLTIVAHEAKKLMPEGGSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGPDNIRVNAISAGPIRTLSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSGVTGENIHVDSGFHAIK 4all C 2.8 BS02 TCL C 1 F96 A97 Y147 Y157 M160 S197 F94 A95 Y145 Y155 M158 S195 Y147 Y157 M160 K164 K199 Y145 Y155 M158 K162 K197 1.3.1.39 0000166,0004318,0006633,0016491,0042802,0141148 A0A0H3JLH9 22579249 1258 NLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEAHLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDISSYSLTIVAHEAKKLMPEGGSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGPDNIRVNAISAGPIRTLSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSGVTGENIHVDSGFHAIK 4all D 2.8 BS01 TCL D 1 A97 Y147 Y157 M160 S197 A95 Y145 Y155 M158 S195 Y147 Y157 M160 K164 K199 Y145 Y155 M158 K162 K197 1.3.1.39 0000166,0004318,0006633,0016491,0042802,0141148 A0A0H3JLH9 22579249 1257 NLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEAHLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDISSYSLTIVAHEAKKLMPEGGSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGPDNIRVNAISAGPIRTLSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSGVTGENIHVDSGFHAIK 4m89 A 1.9 BS02 TCL A 1 G93 A95 L100 Y147 Y157 A197 I201 F204 G92 A94 L99 Y146 Y156 A196 I200 F203 Y157 K164 Y156 K163 1.3.1.9 0000166,0004318,0006633,0016491 A1KVU8 302 GFLQGKKILITGMISERSIAYGIAKACREQGAELAFTYVVDKLEERVRKMAAELDSELVFRCDVASDDEINQVFADLGKHWDGLDGLVHSIGFAPKEALSGDFLDSISREAFNTAHEISAYSLPALAKAARPMMRGRNSAIVALSYLGAVRAIPNYNVMGMAKASLEAGIRFTAACLGKEGIRCNGISAGPIKTLAASGIADFGKLLGHVAAHNPLRRNVTIEEVGNTAAFLLSDLSSGITGEITYVDGGYSINALS 4m89 B 1.9 BS02 TCL B 1 G93 A95 L100 Y147 Y157 A197 I201 F204 G92 A94 L99 Y146 Y156 A196 I200 F203 Y157 K164 Y156 K163 1.3.1.9 0000166,0004318,0006633,0016491 A1KVU8 302 GFLQGKKILITGMISERSIAYGIAKACREQGAELAFTYVVDKLEERVRKMAAELDSELVFRCDVASDDEINQVFADLGKHWDGLDGLVHSIGFAPKEALSGDFLDSISREAFNTAHEISAYSLPALAKAARPMMRGRNSAIVALSYLGAVRAIPNYNVMGMAKASLEAGIRFTAACLGKEGIRCNGISAGPIKTLAASGIADFGKLLGHVAAHNPLRRNVTIEEVGNTAAFLLSDLSSGITGEITYVDGGYSINALS 4nr0 A 1.799 BS02 TCL A 1 G95 A97 L102 Y149 Y159 A199 A200 G94 A96 L101 Y148 Y158 A198 A199 Y159 K166 Y158 K165 1.3.1.9 0004318,0006633,0016491,0030497,0042802 Q9ZFE4 302 GFLTGKRALIVGVASKLSIASGIAAAMHREGAELAFTYQNDKLRGRVEEFASGWGSRPELCFPCDVADDSQIEAVFAALGKHWDGLDIIVHSVGFAPGDQLDGDFTAVTTREGFRIAHDISAYSFIALAKAGREMMKGRNGSLLTLSYLGAERTMPNYNVMGMAKASLEAGVRYLAGSLGAEGTRVNAVSAGPIRTLAASGIKSFRKMLAANERQTPLRRNVTIEEVGNAGAFLCSDLASGISGEILYVDGGFNTTAMG 4nr0 B 1.799 BS02 TCL B 1 G95 A97 L102 Y149 Y159 A199 A200 G94 A96 L101 Y148 Y158 A198 A199 Y159 K166 Y158 K165 1.3.1.9 0004318,0006633,0016491,0030497,0042802 Q9ZFE4 302 GFLTGKRALIVGVASKLSIASGIAAAMHREGAELAFTYQNDKLRGRVEEFASGWGSRPELCFPCDVADDSQIEAVFAALGKHWDGLDIIVHSVGFAPGDQLDGDFTAVTTREGFRIAHDISAYSFIALAKAGREMMKGRNGSLLTLSYLGAERTMPNYNVMGMAKASLEAGVRYLAGSLGAEGTRVNAVSAGPIRTLAASGIKSFRKMLAANERQTPLRRNVTIEEVGNAGAFLCSDLASGISGEILYVDGGFNTTAMG 4nr0 C 1.799 BS02 TCL C 1 G95 A97 L102 Y149 Y159 A199 A200 G94 A96 L101 Y148 Y158 A198 A199 Y159 K166 Y158 K165 1.3.1.9 0004318,0006633,0016491,0030497,0042802 Q9ZFE4 302 GFLTGKRALIVGVASKLSIASGIAAAMHREGAELAFTYQNDKLRGRVEEFASGWGSRPELCFPCDVADDSQIEAVFAALGKHWDGLDIIVHSVGFAPGDQLDGDFTAVTTREGFRIAHDISAYSFIALAKAGREMMKGRNGSLLTLSYLGAERTMPNYNVMGMAKASLEAGVRYLAGSLGAEGTRVNAVSAGPIRTLAASGIKSFRKMLAANERQTPLRRNVTIEEVGNAGAFLCSDLASGISGEILYVDGGFNTTAMGPL 4nr0 D 1.799 BS02 TCL D 1 G95 A97 L102 Y149 Y159 A199 A200 G94 A96 L101 Y148 Y158 A198 A199 Y159 K166 Y158 K165 1.3.1.9 0004318,0006633,0016491,0030497,0042802 Q9ZFE4 302 GFLTGKRALIVGVASKLSIASGIAAAMHREGAELAFTYQNDKLRGRVEEFASGWGSRPELCFPCDVADDSQIEAVFAALGKHWDGLDIIVHSVGFAPGDQLDGDFTAVTTREGFRIAHDISAYSFIALAKAGREMMKGRNGSLLTLSYLGAERTMPNYNVMGMAKASLEAGVRYLAGSLGAEGTRVNAVSAGPIRTLAASGIKSFRKMLAANERQTPLRRNVTIEEVGNAGAFLCSDLASGISGEILYVDGGFNTTAMGPL 4w9n A 1.84 BS01 TCL B 1 F1766 L1780 I1784 F1791 F233 L241 I245 F252 1.1.1.100,1.3.1.39,2.3.1.38,2.3.1.39,2.3.1.41,2.3.1.85,3.1.2.14,4.2.1.59 0016491 -logKd/Ki=4.26, IC50=54.7uM P49327 25301948 1905 HAFVSTLTRGDLSSIRWVCSRHAQPTCPGAQLCTVYYASLNFRDIMLATGKLSPDAIPGKWTSQDSLLGMEFSGRDASGKRVMGLVPAKGLATSVLLSPDFLWDVPSNWTLEEAASVPVVYSTAYYALVVRGRVRPGETLLIHSGSGGVGQAAIAIALSLGCRVFTTVGSAEKRAYLQARFPQLDSTSFANSRSFEQHVLWHTGGKGVDLVLNSLAEEKLQASVRCLATHGRFLEIGKFDLGMAIFLKNVTFHGVLLDAFFNESSADWREVWALVQAGIRDGVVRPLKCTVFHGAQVEDAFRYMAQGKHIGKVVVQVLAEEPE 4w9n B 1.84 BS01 TCL B 1 F1766 L1780 F1791 F222 L231 F242 1.1.1.100,1.3.1.39,2.3.1.38,2.3.1.39,2.3.1.41,2.3.1.85,3.1.2.14,4.2.1.59 0016491 ic50=54.7uM -logKd/Ki=4.26, IC50=54.7uM P49327 25301948 1905 HAFVSTLTRGDLSSIRWVCAQLCTVYYASLNFRDIMLATGKLSPDAIPGKWTSQDSLLGMEFSGRDASGKRVMGLVPAKGLATSVLLSPDFLWDVPSNWTLEEAASVPVVYSTAYYALVVRGRVRPGETLLIHSGSGGVGQAAIAIALSLGCRVFTTVGSAEKRAYLQARFPQLDSTSFANSSFEQHVLWHTGGKGVDLVLNSLAEEKLQASVRCLATHGRFLEIGKFDLLGMAIFLKNVTFHGVLLDAFFNESSADWREVWALVQAGIRDGVVRPLKCTVFHGAQVEDAFRYMAQGKHIGKVVVQVLAEE 4w9n C 1.84 BS01 TCL D 1 L1780 F1791 L237 F248 1.1.1.100,1.3.1.39,2.3.1.38,2.3.1.39,2.3.1.41,2.3.1.85,3.1.2.14,4.2.1.59 0016491 P49327 25301948 1904 HAFVSTLTRGDLSSIRWVCCPGAQLCTVYYASLNFRDIMLATGKLSPDAIPGKWTSQDSLLGMEFSGRDASGKRVMGLVPAKGLATSVLLSPDFLWDVPSNWTLEEAASVPVVYSTAYYALVVRGRVRPGETLLIHSGSGGVGQAAIAIALSLGCRVFTTVGSAEKRAYLQARFPQLDSTSFANSRDTSFEQHVLWHTGGKGVDLVLNSLAEEKLQASVRCLATHGRFLEIGKFDLLGMAIFLKNVTFHGVLLDAFFNESSADWREVWALVQAGIRDGVVRPLKCTVFHGAQVEDAFRYMAQGKHIGKVVVQVLAEEP 4w9n D 1.84 BS01 TCL D 1 L1753 F1766 F1791 L212 F225 F242 1.1.1.100,1.3.1.39,2.3.1.38,2.3.1.39,2.3.1.41,2.3.1.85,3.1.2.14,4.2.1.59 0016491 ic50=54.7uM P49327 25301948 1904 HAFVSTLTRGDLSSIRWVCCPGAQLCTVYYASLNFRDIMLATGKLSPDAIPGKWTSQDSLLGMEFSGRDASGKRVMGLVPAKGLATSVLLSPDFLWDVPSNWTLEEAASVPVVYSTAYYALVVRGRVRPGETLLIHSGSGGVGQAAIAIALSLGCRVFTTVGSAEKRAYLQARFPQLDSTSFANSSFEQHVLWHTGGKGVDLVLNSLAEEKLQASVRCLATHGRFLEIGKLGMAIFLKNVTFHGVLLDAFFNESSADWREVWALVQAGIRDGVVRPLKCTVFHGAQVEDAFRYMAQHIGKVVVQVLAEEP 5ifl A 2.6 BS01 TCL A 1 G93 A95 I100 Y146 Y156 A196 I200 F203 G92 A94 I99 Y145 Y155 A195 I199 F202 Y156 K163 Y155 K162 1.3.1.9 0000166,0004318,0006633,0016491 A0A0H3HP34 28225601 301 GFLDGKRILLTGLLSNRSIAYGIAKACKREGAELAFTYVGDRFKDRITEFAAEFGSELVFPCDVADDAQIDALFASLKTHWDSLDGLVHSIGFAPREAIAGDFLDGLTRENFRIAHDISAYSFPALAKAALPMLSDDASLLTLSYLGAERAIPNYNTMGLAKAALEASVRYLAVSLGAKGVRVNAISAGPIKTLAASGIKSFGKILDFVESNSPLKRNVTIEQVGNAGAFLLSDLASGVTAEVMHVDSGFNAVVG 5ifl B 2.6 BS01 TCL B 1 A95 I100 Y146 Y156 P191 A196 A197 I200 F203 A94 I99 Y145 Y155 P190 A195 A196 I199 F202 Y156 K163 Y155 K162 1.3.1.9 0000166,0004318,0006633,0016491 A0A0H3HP34 28225601 301 GFLDGKRILLTGLLSNRSIAYGIAKACKREGAELAFTYVGDRFKDRITEFAAEFGSELVFPCDVADDAQIDALFASLKTHWDSLDGLVHSIGFAPREAIAGDFLDGLTRENFRIAHDISAYSFPALAKAALPMLSDDASLLTLSYLGAERAIPNYNTMGLAKAALEASVRYLAVSLGAKGVRVNAISAGPIKTLAASGIKSFGKILDFVESNSPLKRNVTIEQVGNAGAFLLSDLASGVTAEVMHVDSGFNAVVG 5ifl C 2.6 BS01 TCL C 1 G93 F94 A95 I100 Y146 Y156 A196 I200 F203 G92 F93 A94 I99 Y145 Y155 A195 I199 F202 Y156 K163 Y155 K162 1.3.1.9 0000166,0004318,0006633,0016491 A0A0H3HP34 28225601 301 GFLDGKRILLTGLLSNRSIAYGIAKACKREGAELAFTYVGDRFKDRITEFAAEFGSELVFPCDVADDAQIDALFASLKTHWDSLDGLVHSIGFAPREAIAGDFLDGLTRENFRIAHDISAYSFPALAKAALPMLSDDASLLTLSYLGAERAIPNYNTMGLAKAALEASVRYLAVSLGAKGVRVNAISAGPIKTLAASGIKSFGKILDFVESNSPLKRNVTIEQVGNAGAFLLSDLASGVTAEVMHVDSGFNAVVG 5ifl D 2.6 BS01 TCL D 1 G93 A95 I100 Y146 Y156 A196 I200 F203 G92 A94 I99 Y145 Y155 A195 I199 F202 Y156 K163 Y155 K162 1.3.1.9 0000166,0004318,0006633,0016491 A0A0H3HP34 28225601 301 GFLDGKRILLTGLLSNRSIAYGIAKACKREGAELAFTYVGDRFKDRITEFAAEFGSELVFPCDVADDAQIDALFASLKTHWDSLDGLVHSIGFAPREAIAGDFLDGLTRENFRIAHDISAYSFPALAKAALPMLSDDASLLTLSYLGAERAIPNYNTMGLAKAALEASVRYLAVSLGAKGVRVNAISAGPIKTLAASGIKSFGKILDFVESNSPLKRNVTIEQVGNAGAFLLSDLASGVTAEVMHVDSGFNAVVG 5ifl E 2.6 BS01 TCL E 1 G93 A95 Y146 Y156 A196 I200 F203 G92 A94 Y145 Y155 A195 I199 F202 Y156 K163 Y155 K162 1.3.1.9 0000166,0004318,0006633,0016491 A0A0H3HP34 28225601 301 GFLDGKRILLTGLLSNRSIAYGIAKACKREGAELAFTYVGDRFKDRITEFAAEFGSELVFPCDVADDAQIDALFASLKTHWDSLDGLVHSIGFAPREAIAGDFLDGLTRENFRIAHDISAYSFPALAKAALPMLSDDASLLTLSYLGAERAIPNYNTMGLAKAALEASVRYLAVSLGAKGVRVNAISAGPIKTLAASGIKSFGKILDFVESNSPLKRNVTIEQVGNAGAFLLSDLASGVTAEVMHVDSGFNAVVG 5ifl F 2.6 BS01 TCL F 1 G93 A95 I100 Y146 Y156 A196 I200 F203 G92 A94 I99 Y145 Y155 A195 I199 F202 Y156 K163 Y155 K162 1.3.1.9 0000166,0004318,0006633,0016491 A0A0H3HP34 28225601 301 GFLDGKRILLTGLLSNRSIAYGIAKACKREGAELAFTYVGDRFKDRITEFAAEFGSELVFPCDVADDAQIDALFASLKTHWDSLDGLVHSIGFAPREAIAGDFLDGLTRENFRIAHDISAYSFPALAKAALPMLSDDASLLTLSYLGAERAIPNYNTMGLAKAALEASVRYLAVSLGAKGVRVNAISAGPIKTLAASGIKSFGKILDFVESNSPLKRNVTIEQVGNAGAFLLSDLASGVTAEVMHVDSGFNAVVG 5ifl G 2.6 BS01 TCL G 1 G93 A95 I100 Y146 Y156 A196 I200 F203 G92 A94 I99 Y145 Y155 A195 I199 F202 Y156 K163 Y155 K162 1.3.1.9 0000166,0004318,0006633,0016491 A0A0H3HP34 28225601 301 GFLDGKRILLTGLLSNRSIAYGIAKACKREGAELAFTYVGDRFKDRITEFAAEFGSELVFPCDVADDAQIDALFASLKTHWDSLDGLVHSIGFAPREAIAGDFLDGLTRENFRIAHDISAYSFPALAKAALPMLSDDASLLTLSYLGAERAIPNYNTMGLAKAALEASVRYLAVSLGAKGVRVNAISAGPIKTLAASGIKSFGKILDFVESNSPLKRNVTIEQVGNAGAFLLSDLASGVTAEVMHVDSGFNAVVG 5ifl H 2.6 BS01 TCL H 1 G93 A95 I100 Y146 Y156 A196 I200 F203 G92 A94 I99 Y145 Y155 A195 I199 F202 Y156 K163 Y155 K162 1.3.1.9 0000166,0004318,0006633,0016491 A0A0H3HP34 28225601 301 GFLDGKRILLTGLLSNRSIAYGIAKACKREGAELAFTYVGDRFKDRITEFAAEFGSELVFPCDVADDAQIDALFASLKTHWDSLDGLVHSIGFAPREAIAGDFLDGLTRENFRIAHDISAYSFPALAKAALPMLSDDASLLTLSYLGAERAIPNYNTMGLAKAALEASVRYLAVSLGAKGVRVNAISAGPIKTLAASGIKSFGKILDFVESNSPLKRNVTIEQVGNAGAFLLSDLASGVTAEVMHVDSGFNAVVG 5ifl I 2.6 BS01 TCL I 1 G93 A95 I100 Y146 Y156 A196 A197 I200 G92 A94 I99 Y145 Y155 A195 A196 I199 Y156 K163 Y155 K162 1.3.1.9 0000166,0004318,0006633,0016491 A0A0H3HP34 28225601 301 GFLDGKRILLTGLLSNRSIAYGIAKACKREGAELAFTYVGDRFKDRITEFAAEFGSELVFPCDVADDAQIDALFASLKTHWDSLDGLVHSIGFAPREAIAGDFLDGLTRENFRIAHDISAYSFPALAKAALPMLSDDASLLTLSYLGAERAIPNYNTMGLAKAALEASVRYLAVSLGAKGVRVNAISAGPIKTLAASGIKSFGKILDFVESNSPLKRNVTIEQVGNAGAFLLSDLASGVTAEVMHVDSGFNAVVG 5ifl J 2.6 BS01 TCL J 1 G93 A95 I100 Y146 Y156 A196 I200 F203 G92 A94 I99 Y145 Y155 A195 I199 F202 Y156 K163 Y155 K162 1.3.1.9 0000166,0004318,0006633,0016491 A0A0H3HP34 28225601 301 GFLDGKRILLTGLLSNRSIAYGIAKACKREGAELAFTYVGDRFKDRITEFAAEFGSELVFPCDVADDAQIDALFASLKTHWDSLDGLVHSIGFAPREAIAGDFLDGLTRENFRIAHDISAYSFPALAKAALPMLSDDASLLTLSYLGAERAIPNYNTMGLAKAALEASVRYLAVSLGAKGVRVNAISAGPIKTLAASGIKSFGKILDFVESNSPLKRNVTIEQVGNAGAFLLSDLASGVTAEVMHVDSGFNAVVG 5ifl K 2.6 BS01 TCL K 1 G93 A95 I100 Y146 Y156 A196 I200 F203 G92 A94 I99 Y145 Y155 A195 I199 F202 Y156 K163 Y155 K162 1.3.1.9 0000166,0004318,0006633,0016491 A0A0H3HP34 28225601 301 GFLDGKRILLTGLLSNRSIAYGIAKACKREGAELAFTYVGDRFKDRITEFAAEFGSELVFPCDVADDAQIDALFASLKTHWDSLDGLVHSIGFAPREAIAGDFLDGLTRENFRIAHDISAYSFPALAKAALPMLSDDASLLTLSYLGAERAIPNYNTMGLAKAALEASVRYLAVSLGAKGVRVNAISAGPIKTLAASGIKSFGKILDFVESNSPLKRNVTIEQVGNAGAFLLSDLASGVTAEVMHVDSGFNAVVG 5ifl L 2.6 BS01 TCL L 1 G93 F94 A95 I100 Y146 Y156 A196 A197 I200 F203 G92 F93 A94 I99 Y145 Y155 A195 A196 I199 F202 Y156 K163 Y155 K162 1.3.1.9 0000166,0004318,0006633,0016491 A0A0H3HP34 28225601 301 GFLDGKRILLTGLLSNRSIAYGIAKACKREGAELAFTYVGDRFKDRITEFAAEFGSELVFPCDVADDAQIDALFASLKTHWDSLDGLVHSIGFAPREAIAGDFLDGLTRENFRIAHDISAYSFPALAKAALPMLSDDASLLTLSYLGAERAIPNYNTMGLAKAALEASVRYLAVSLGAKGVRVNAISAGPIKTLAASGIKSFGKILDFVESNSPLKRNVTIEQVGNAGAFLLSDLASGVTAEVMHVDSGFNAVVG 5ifl M 2.6 BS01 TCL M 1 G93 A95 I100 Y146 Y156 A196 I200 G92 A94 I99 Y145 Y155 A195 I199 Y156 K163 Y155 K162 1.3.1.9 0000166,0004318,0006633,0016491 A0A0H3HP34 28225601 301 GFLDGKRILLTGLLSNRSIAYGIAKACKREGAELAFTYVGDRFKDRITEFAAEFGSELVFPCDVADDAQIDALFASLKTHWDSLDGLVHSIGFAPREAIAGDFLDGLTRENFRIAHDISAYSFPALAKAALPMLSDDASLLTLSYLGAERAIPNYNTMGLAKAALEASVRYLAVSLGAKGVRVNAISAGPIKTLAASGIKSFGKILDFVESNSPLKRNVTIEQVGNAGAFLLSDLASGVTAEVMHVDSGFNAVVG 5ifl N 2.6 BS01 TCL N 1 G93 A95 I100 Y146 Y156 P191 A196 I200 F203 G92 A94 I99 Y145 Y155 P190 A195 I199 F202 Y156 K163 Y155 K162 1.3.1.9 0000166,0004318,0006633,0016491 A0A0H3HP34 28225601 301 GFLDGKRILLTGLLSNRSIAYGIAKACKREGAELAFTYVGDRFKDRITEFAAEFGSELVFPCDVADDAQIDALFASLKTHWDSLDGLVHSIGFAPREAIAGDFLDGLTRENFRIAHDISAYSFPALAKAALPMLSDDASLLTLSYLGAERAIPNYNTMGLAKAALEASVRYLAVSLGAKGVRVNAISAGPIKTLAASGIKSFGKILDFVESNSPLKRNVTIEQVGNAGAFLLSDLASGVTAEVMHVDSGFNAVVG 5ifl O 2.6 BS01 TCL O 1 G93 A95 Y146 Y156 A196 I200 F203 G92 A94 Y145 Y155 A195 I199 F202 Y156 K163 Y155 K162 1.3.1.9 0000166,0004318,0006633,0016491 A0A0H3HP34 28225601 301 GFLDGKRILLTGLLSNRSIAYGIAKACKREGAELAFTYVGDRFKDRITEFAAEFGSELVFPCDVADDAQIDALFASLKTHWDSLDGLVHSIGFAPREAIAGDFLDGLTRENFRIAHDISAYSFPALAKAALPMLSDDASLLTLSYLGAERAIPNYNTMGLAKAALEASVRYLAVSLGAKGVRVNAISAGPIKTLAASGIKSFGKILDFVESNSPLKRNVTIEQVGNAGAFLLSDLASGVTAEVMHVDSGFNAVVG 5ifl P 2.6 BS01 TCL P 1 G93 F94 A95 I100 Y146 Y156 A196 I200 G92 F93 A94 I99 Y145 Y155 A195 I199 Y156 K163 Y155 K162 1.3.1.9 0000166,0004318,0006633,0016491 A0A0H3HP34 28225601 301 GFLDGKRILLTGLLSNRSIAYGIAKACKREGAELAFTYVGDRFKDRITEFAAEFGSELVFPCDVADDAQIDALFASLKTHWDSLDGLVHSIGFAPREAIAGDFLDGLTRENFRIAHDISAYSFPALAKAALPMLSDDASLLTLSYLGAERAIPNYNTMGLAKAALEASVRYLAVSLGAKGVRVNAISAGPIKTLAASGIKSFGKILDFVESNSPLKRNVTIEQVGNAGAFLLSDLASGVTAEVMHVDSGFNAVVG 5ycs A 1.95 BS02 TCL A 1 A95 A97 Y147 Y157 M160 S197 A95 A97 Y147 Y157 M160 S197 1.3.1.9 0000166,0004318,0006633,0016491,0030497,0036094,0042802,0070401,0141148,1902494 Q81GI3 28935372 502 MELLQGKTFVVMGVANQRSIAWGIARSLHNAGAKLIFTYAGERLERNVRELADTLEGQESLVLPCDVTNDEELTACFETIKQEVGTIHGVAHCIAFANRDDLKGEFVDTSRDGFLLAQNISAFSLTAVAREAKKVMTEGGNILTLTYLGGERVVKNYNVMGVAKASLEASVKYLANDLGQHGIRVNAISAGPIRTLSAKGVGDFNSILREIEERAPLRRTTTQEEVGDTAVFLFSDLARGVTGENIHVDSGYHILG 5ycs B 1.95 BS02 TCL B 1 A95 A97 Y147 Y157 M160 S197 A95 A97 Y147 Y157 M160 S197 1.3.1.9 0000166,0004318,0006633,0016491,0030497,0036094,0042802,0070401,0141148,1902494 Q81GI3 28935372 302 MELLQGKTFVVMGVANQRSIAWGIARSLHNAGAKLIFTYAGERLERNVRELADTLEGQESLVLPCDVTNDEELTACFETIKQEVGTIHGVAHCIAFANRDDLKGEFVDTSRDGFLLAQNISAFSLTAVAREAKKVMTEGGNILTLTYLGGERVVKNYNVMGVAKASLEASVKYLANDLGQHGIRVNAISAGPIRTLSAKGVGDFNSILREIEERAPLRRTTTQEEVGDTAVFLFSDLARGVTGENIHVDSGYHILG 5ycs C 1.95 BS02 TCL C 1 A95 A97 Y147 Y157 M160 S197 A95 A97 Y147 Y157 M160 S197 1.3.1.9 0000166,0004318,0006633,0016491,0030497,0036094,0042802,0070401,0141148,1902494 Q81GI3 28935372 302 MELLQGKTFVVMGVANQRSIAWGIARSLHNAGAKLIFTYAGERLERNVRELADTLEGQESLVLPCDVTNDEELTACFETIKQEVGTIHGVAHCIAFANRDDLKGEFVDTSRDGFLLAQNISAFSLTAVAREAKKVMTEGGNILTLTYLGGERVVKNYNVMGVAKASLEASVKYLANDLGQHGIRVNAISAGPIRTLSAKGVGDFNSILREIEERAPLRRTTTQEEVGDTAVFLFSDLARGVTGENIHVDSGYHILG 5ycs D 1.95 BS02 TCL D 1 A95 A97 Y147 Y157 M160 S197 A95 A97 Y147 Y157 M160 S197 1.3.1.9 0000166,0004318,0006633,0016491,0030497,0036094,0042802,0070401,0141148,1902494 Q81GI3 28935372 302 MELLQGKTFVVMGVANQRSIAWGIARSLHNAGAKLIFTYAGERLERNVRELADTLEGQESLVLPCDVTNDEELTACFETIKQEVGTIHGVAHCIAFANRDDLKGEFVDTSRDGFLLAQNISAFSLTAVAREAKKVMTEGGNILTLTYLGGERVVKNYNVMGVAKASLEASVKYLANDLGQHGIRVNAISAGPIRTLSAKGVGDFNSILREIEERAPLRRTTTQEEVGDTAVFLFSDLARGVTGENIHVDSGYHILG 6ah9 A 1.74 BS02 TCL A 1 G95 A97 L102 Y149 Y159 A199 G93 A95 L100 Y147 Y157 A197 1.3.1.9 0000166,0004318,0006633,0016491 D0CAD5 302 QGLLAGKRFLIAGVASKLSIAYGIAQALHREGAELAFTYPNEKLKKRVDEFAEQFGSKLVFPCDVAVDAEIDNAFAELAKHWDGVDGVVHSIGFAPAHTLDGDFTDVTDRDGFKIAHDISAYSFVAMARAAKPLLQARQGCLLTLTYQGSERVMPNYNVMGMAKASLEAGVRYLASSLGVDGIRVNAISAGPIRTLAASGIKSFRKMLDANEKVAPLKRNVTIEEVGNAALFLCSPWASGITGEILYVDAGFNTVGMSQS 7fcm A 2.22 BS02 TCL A 1 G97 A99 L104 Y151 Y161 A201 A202 G99 A101 L106 Y153 Y163 A203 A204 0004318,0006633 35276316 302 QSMLLKGQRFVVTGIASKLSIAWAIAESLHREGAQLILTYPNDKIKKRVDMAAEAFDAVAVIECDVGSDESIQVCFDEIAKHWGVGDDKGIDGIVHAIGFAPADQLDGDFTQATTREGSQIAHDISSYSFVALAKAGRELLAARQGSLLTLTYEGSISVLPNYNVMGMAKASLEASVRYLASSLGGEGIRVNAISAGPIRTLAASGIKSFRRMLDVSEKIAPLQRNVSQEEVGNAALFLLSPWASGITGEILFVDAGFNTVAISEKIM 7fcm B 2.22 BS03 TCL B 1 G97 A99 L104 Y151 Y161 A201 A202 I205 G99 A101 L106 Y153 Y163 A203 A204 I207 0004318,0006633 35276316 302 QSMLLKGQRFVVTGIASKLSIAWAIAESLHREGAQLILTYPNDKIKKRVDMAAEAFDAVAVIECDVGSDESIQVCFDEIAKHWGVGDDKGIDGIVHAIGFAPADQLDGDFTQATTREGSQIAHDISSYSFVALAKAGRELLAARQGSLLTLTYEGSISVLPNYNVMGMAKASLEASVRYLASSLGGEGIRVNAISAGPIRTLAASGIKSFRRMLDVSEKIAPLQRNVSQEEVGNAALFLLSPWASGITGEILFVDAGFNTVAISEKIMM