2onc	A	2.55	BS01	SY1	A	1	E205 E206 F357 Y547 S630 Y631 Y662 Y666 V711	E163 E164 F315 Y505 S588 Y589 Y620 Y624 V669	Y547 S630 Y631 D708 H740	Y505 S588 Y589 D666 H698	3.4.14.5	0001618,0001662,0001666,0002020,0004177,0004252,0005102,0005515,0005576,0005765,0005886,0005925,0006508,0007155,0008236,0008239,0008284,0009986,0010716,0016020,0016324,0016486,0019065,0030027,0030139,0031258,0031295,0033632,0035641,0036343,0042110,0042802,0042803,0042995,0043542,0045121,0045499,0046581,0046718,0046813,0050919,0061025,0070062,0070161,0090024,0120116			-logKd/Ki=7.89, IC50=13nM	IC50=13nM	P27487	17441705	800 	AKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKNILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNYVKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNLPSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFYSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSLSSVTNATSIQITAPASMLIGDHYLCDVTWATQERISLQWLRRIQNYSVMDICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPSEPHFTLDGNSFYKIISNEEGYRHICYFQIDKKDCTFITKGTWEVIGIEALTSDYLYYISNEYKGMPGGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPGLPLYTLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWYQMILPPHFDKSKKYPLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISKALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP
2onc	A	2.55	BS02	SY1	A	2	E191 D192 F240 K250 R253	E149 D150 F198 K208 R211	Y547 S630 Y631 D708 H740	Y505 S588 Y589 D666 H698	3.4.14.5	0001618,0001662,0001666,0002020,0004177,0004252,0005102,0005515,0005576,0005765,0005886,0005925,0006508,0007155,0008236,0008239,0008284,0009986,0010716,0016020,0016324,0016486,0019065,0030027,0030139,0031258,0031295,0033632,0035641,0036343,0042110,0042802,0042803,0042995,0043542,0045121,0045499,0046581,0046718,0046813,0050919,0061025,0070062,0070161,0090024,0120116			-logKd/Ki=7.89, IC50=13nM	IC50=13nM	P27487	17441705	801 	AKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKNILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNYVKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNLPSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFYSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSLSSVTNATSIQITAPASMLIGDHYLCDVTWATQERISLQWLRRIQNYSVMDICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPSEPHFTLDGNSFYKIISNEEGYRHICYFQIDKKDCTFITKGTWEVIGIEALTSDYLYYISNEYKGMPGGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPGLPLYTLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWYQMILPPHFDKSKKYPLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISKALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP
2onc	B	2.55	BS01	SY1	B	1	E205 E206 Y547 S630 Y631 V656 Y662 Y666 V711	E167 E168 Y509 S592 Y593 V618 Y624 Y628 V673	Y547 S630 Y631 D708 H740	Y509 S592 Y593 D670 H702	3.4.14.5	0001618,0001662,0001666,0002020,0004177,0004252,0005102,0005515,0005576,0005765,0005886,0005925,0006508,0007155,0008236,0008239,0008284,0009986,0010716,0016020,0016324,0016486,0019065,0030027,0030139,0031258,0031295,0033632,0035641,0036343,0042110,0042802,0042803,0042995,0043542,0045121,0045499,0046581,0046718,0046813,0050919,0061025,0070062,0070161,0090024,0120116				IC50=13nM	P27487	17441705	800 	HHASAKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKNILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNYVKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNLPSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFYSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSLSSVTNATSIQITAPASMLIGDHYLCDVTWATQERISLQWLRRIQNYSVMDICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPSEPHFTLDGNSFYKIISNEEGYRHICYFQIDKKDCTFITKGTWEVIGIEALTSDYLYYISNEYKGMPGGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPGLPLYTLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWYQMILPPHFDKSKKYPLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISKALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP
2onc	B	2.55	BS02	SY1	B	2	Q123 D192 F240 K250 V252 R253	Q85 D154 F202 K212 V214 R215	Y547 S630 Y631 D708 H740	Y509 S592 Y593 D670 H702	3.4.14.5	0001618,0001662,0001666,0002020,0004177,0004252,0005102,0005515,0005576,0005765,0005886,0005925,0006508,0007155,0008236,0008239,0008284,0009986,0010716,0016020,0016324,0016486,0019065,0030027,0030139,0031258,0031295,0033632,0035641,0036343,0042110,0042802,0042803,0042995,0043542,0045121,0045499,0046581,0046718,0046813,0050919,0061025,0070062,0070161,0090024,0120116				IC50=13nM	P27487	17441705	801 	HHASAKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKNILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNYVKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNLPSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFYSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSLSSVTNATSIQITAPASMLIGDHYLCDVTWATQERISLQWLRRIQNYSVMDICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPSEPHFTLDGNSFYKIISNEEGYRHICYFQIDKKDCTFITKGTWEVIGIEALTSDYLYYISNEYKGMPGGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPGLPLYTLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWYQMILPPHFDKSKKYPLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISKALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP
2onc	C	2.55	BS01	SY1	C	1	E205 E206 Y547 S630 Y631 V656 Y662 Y666 V711	E164 E165 Y504 S587 Y588 V613 Y619 Y623 V668	Y547 S630 Y631 D708 H740	Y504 S587 Y588 D665 H697	3.4.14.5	0001618,0001662,0001666,0002020,0004177,0004252,0005102,0005515,0005576,0005765,0005886,0005925,0006508,0007155,0008236,0008239,0008284,0009986,0010716,0016020,0016324,0016486,0019065,0030027,0030139,0031258,0031295,0033632,0035641,0036343,0042110,0042802,0042803,0042995,0043542,0045121,0045499,0046581,0046718,0046813,0050919,0061025,0070062,0070161,0090024,0120116				IC50=13nM	P27487	17441705	800 	AKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKNNILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNYVKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNLPSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFYSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSLSSVTNATSIQITAPASMLIGDHYLCDVTWATQERISLQWLRRIQNYSVMDICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPSEPHFTLDGNSFYKIISNEEGYRHICYFQIDKCTFITKGTWEVIGIEALTSDYLYYISNEYKGMPGGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPGLPLYTLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWYQMILPPHFDKSKKYPLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISKALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP
2onc	C	2.55	BS02	SY1	C	2	Q123 D192 F240 K250 R253	Q82 D151 F199 K209 R212	Y547 S630 Y631 D708 H740	Y504 S587 Y588 D665 H697	3.4.14.5	0001618,0001662,0001666,0002020,0004177,0004252,0005102,0005515,0005576,0005765,0005886,0005925,0006508,0007155,0008236,0008239,0008284,0009986,0010716,0016020,0016324,0016486,0019065,0030027,0030139,0031258,0031295,0033632,0035641,0036343,0042110,0042802,0042803,0042995,0043542,0045121,0045499,0046581,0046718,0046813,0050919,0061025,0070062,0070161,0090024,0120116				IC50=13nM	P27487	17441705	801 	AKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKNNILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNYVKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNLPSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFYSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSLSSVTNATSIQITAPASMLIGDHYLCDVTWATQERISLQWLRRIQNYSVMDICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPSEPHFTLDGNSFYKIISNEEGYRHICYFQIDKCTFITKGTWEVIGIEALTSDYLYYISNEYKGMPGGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPGLPLYTLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWYQMILPPHFDKSKKYPLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISKALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP
2onc	D	2.55	BS01	SY1	D	1	E205 E206 Y547 S630 Y631 V656 Y662 Y666 V711	E163 E164 Y503 S586 Y587 V612 Y618 Y622 V667	Y547 S630 Y631 D708 H740	Y503 S586 Y587 D664 H696	3.4.14.5	0001618,0001662,0001666,0002020,0004177,0004252,0005102,0005515,0005576,0005765,0005886,0005925,0006508,0007155,0008236,0008239,0008284,0009986,0010716,0016020,0016324,0016486,0019065,0030027,0030139,0031258,0031295,0033632,0035641,0036343,0042110,0042802,0042803,0042995,0043542,0045121,0045499,0046581,0046718,0046813,0050919,0061025,0070062,0070161,0090024,0120116				IC50=13nM	P27487	17441705	800 	AKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKNILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNYVKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNLPSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFYSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSLSSVTNATSIQITAPASMLIGDHYLCDVTWATQERISLQWLRRIQNYSVMDICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPSEPHFTLDGNSFYKIISNEEGYRHICYFQIDDCTFITKGTWEVIGIEALTSDYLYYISNEYKGMPGGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPGLPLYTLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWYQMILPPHFDKSKKYPLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISKALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP
2onc	D	2.55	BS02	SY1	D	2	D192 F240 K250 V252 R253	D150 F198 K208 V210 R211	Y547 S630 Y631 D708 H740	Y503 S586 Y587 D664 H696	3.4.14.5	0001618,0001662,0001666,0002020,0004177,0004252,0005102,0005515,0005576,0005765,0005886,0005925,0006508,0007155,0008236,0008239,0008284,0009986,0010716,0016020,0016324,0016486,0019065,0030027,0030139,0031258,0031295,0033632,0035641,0036343,0042110,0042802,0042803,0042995,0043542,0045121,0045499,0046581,0046718,0046813,0050919,0061025,0070062,0070161,0090024,0120116				IC50=13nM	P27487	17441705	801 	AKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKNILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNYVKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNLPSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFYSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSLSSVTNATSIQITAPASMLIGDHYLCDVTWATQERISLQWLRRIQNYSVMDICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPSEPHFTLDGNSFYKIISNEEGYRHICYFQIDDCTFITKGTWEVIGIEALTSDYLYYISNEYKGMPGGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPGLPLYTLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWYQMILPPHFDKSKKYPLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISKALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP