4s0v A 2.5 BS01 SUV A 1 T111 P131 Q134 N324 H350 T62 P82 Q85 N423 H447 ? 0004930,0007186,0007631,0016020,0016499 O43614,Q9V2J8 25533960 2001 PKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQGIDCSFWNESYLTGSRDERKKSLLSKFGMDEGVTFMFIGRFDRGQKGVDVLLKAIEILSSKKEFQEMRFIIIGKGDPELEGWARSLEEKHGNVKVITEMLSREFVRELYGSVDFVIIPSYFEPFGLVALEAMCLGAIPIASAVGGLRDIITNETGILVKAGDPGELANAILKALELSRSDLSKFRENCKKRAMSFSKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFAHDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSC 4zj8 A 2.751 BS01 SUV A 1 A102 S103 P123 Q126 V130 Q179 F219 I314 N318 H344 Y348 A77 S78 P98 Q101 V105 Q154 F194 I444 N448 H474 Y478 ? 0004930,0007186,0007631,0016020,0016499 -logKd/Ki=9.26, Ki=0.55nM O43613,Q9V2J8 26950369 2001 DYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQGIDCSFWNESYLTGSRDERKKSLLSKFGMDEGVTFMFIGRFDRGQKGVDVLLKAIEILSSKKEFQEMRFIIIGKGDPELEGWARSLEEKHGNVKVITEMLSREFVRELYGSVDFVIIPSYFEPFGLVALEAMCLGAIPIASAVGGLRDIITNETGILVKAGDPGELANAILKALELSRSDLSKFRENCKKRAMSFSKQMRARRKTAKMLMVVLLVFALCYLPISVLNILKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAF 6to7 A 2.26 BS01 SUV A 1 A102 S103 P123 Q126 V130 Q179 F219 I314 N318 H344 A58 S59 P79 Q82 V86 Q135 F175 I237 N241 H267 ? 0004930,0007186,0007631,0016020,0016499 IC50=50nM, Ki=0.600000nM O43613 31860301 401 YAWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRALGSILGIWAVSLAIMVPQAAVMECSSVLPELAARTRAFSVCDERWADDLAPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRIPGTTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGMFRQASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSWWL 6to7 B 2.26 BS02 SUV B 1 A102 S103 P123 Q126 V130 Q179 F219 I314 N318 H344 A73 S74 P94 Q97 V101 Q150 F179 I238 N242 H268 ? 0004930,0007186,0007631,0016020,0016499 IC50=50nM, Ki=0.600000nM O43613 31860301 401 EFLRYLWRDYLYPKQYAWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRALGSILGIWAVSLAIMVPQAAVMECSSFSVCDERWADDLAPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGGTTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGMFRQASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSWWLPGLAAA 6tpj A 2.74 BS01 SUV A 1 A110 T111 I130 Q134 T135 Q187 F227 I320 N324 H350 A64 T65 I84 Q88 T89 Q141 F181 I431 N435 H461 ? 0004930,0007186,0007631,0016020,0016499 O43614,Q9V2J8 31860301 1202 YLHPKEYAWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNLFIVNLSLAAVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSALTLSCIALDRWYAICHPLMFKSTAKRALNSIVIIWIVSCIIMIPQAIVMECSTVFPGLADKTTAFTVCDERWGGEIAPKMYHICFFLVTYAAPLCLMVLLYLQIFRKLWCRQGIDCSFWNESYLTGSRDERKKSLLSKFGMDEGVTFMFIGRFDRGQKGVDVLLKAIEILSSKKEFQEMRFIIIGKGDPELEGWARSLEEKHGNVKVITEMLSREFVRELYGSVDFVIIPSYFEPFGLVALEAMCLGAIPIASAVGGLRDIITNETGILVKAGDPGELANAILKALELSRSDLSKFRENCKKRAMSFSKQIRARRKTARMLMVVVLVFAICYAPISILNVLKRVFGMFAHTEDRETVYAWFAFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSWWWLGVHH 6tpj B 2.74 BS01 SUV B 1 A110 T111 I130 P131 Q134 T135 Q187 E212 N324 H350 A66 T67 I86 P87 Q90 T91 Q143 E168 N437 H463 ? 0004930,0007186,0007631,0016020,0016499 O43614,Q9V2J8 31860301 2101 REYLHPKEYAWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNLFIVNLSLAAVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSALTLSCIALDRWYAICHPLMFKSTAKRALNSIVIIWIVSCIIMIPQAIVMECSTVFPGLADKTTAFTVCDERWGGEIAPKMYHICFFLVTYAAPLCLMVLLYLQIFRKLWCRQGIDCSFWNESYLTGSRDERKKSLLSKFGMDEGVTFMFIGRFDRGQKGVDVLLKAIEILSSKKEFQEMRFIIIGKGDPELEGWARSLEEKHGNVKVITEMLSREFVRELYGSVDFVIIPSYFEPFGLVALEAMCLGAIPIASAVGGLRDIITNETGILVKAGDPGELANAILKALELSRSDLSKFRENCKKRAMSFSKQIRARRKTARMLMVVVLVFAICYAPISILNVLKRVFGMFAHTEDRETVYAWFAFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSWWWLGVHH