1aq1 A 2.0 BS01 STU A 1 I10 G13 A31 E81 F82 L83 H84 Q85 D86 Q131 L134 D145 I10 G13 A31 E73 F74 L75 H76 Q77 D78 Q123 L126 D137 D127 K129 Q131 N132 D145 T165 D119 K121 Q123 N124 D137 T144 2.7.11.22 0000082,0000086,0000122,0000287,0000307,0000781,0000793,0000805,0000806,0001673,0004672,0004674,0004693,0005515,0005524,0005634,0005635,0005654,0005667,0005737,0005768,0005813,0005829,0005856,0006260,0006281,0006338,0006351,0006468,0006813,0007099,0007165,0007265,0007346,0008284,0010389,0010468,0015030,0016301,0016310,0018105,0019904,0030332,0031453,0031571,0032298,0035173,0043247,0043687,0045740,0045893,0046872,0051298,0051301,0051321,0071732,0090398,0097123,0097124,0097134,0097135,0097472,0106310,1905784 -logKd/Ki=8.15, IC50=7nM P24941 9334743 299 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 1byg A 2.4 BS01 STU A 1 I201 K203 V209 A220 T266 E267 Y268 M269 G272 R318 N319 L321 I15 K17 V23 A34 T76 E77 Y78 M79 G82 R128 N129 L131 D314 A316 R318 N319 D332 P349 D124 A126 R128 N129 D142 P147 2.7.10.2 0004672,0004713,0005524,0006468 P41240 9878439 501 GWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDAQAFLAEASVMTQLRHSNLVQLLGVIVEEGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQLEHIKTHEL 1e8z A 2.4 BS01 STU A 1 M804 S806 K807 W812 I831 K833 Y867 I879 E880 V882 M953 I963 D964 M565 S567 K568 W573 I592 K594 Y628 I640 E641 V643 M713 I723 D724 2.7.11.1,2.7.1.137,2.7.1.153,2.7.1.154 0016301,0046854 P48736 11090628 3001 SEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEECDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCLLYYVNLLLIDHRFLLRRGEYVLHMWQISGFNADKLTSATNPDKENSMSISILLDNHPIARAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVL 1nvr A 1.8 BS02 STU A 1 L15 Y20 V23 A36 K38 E85 Y86 C87 G90 E91 E134 L137 D148 L13 Y18 V21 A34 K36 E76 Y77 C78 G81 E82 E125 L128 D139 D130 K132 E134 N135 D148 T170 D121 K123 E125 N126 D139 T161 2.7.11.1 0000077,0004672,0004674,0005524,0006468 Ki=7.8nM -logKd/Ki=8.11, Ki=7.8nM O14757 12244092 400 VPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKNIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKKGA 1nxk A 2.7 BS01 STU A 1 L70 G71 G73 V78 A91 M138 C140 L141 E190 L193 T206 D207 L29 G30 G32 V37 A50 M97 C99 L100 E146 L149 T162 D163 D186 K188 E190 N191 D207 D142 K144 E146 N147 D163 2.7.11.1 0000165,0002224,0004672,0004674,0004683,0005515,0005516,0005524,0005634,0005654,0005737,0005813,0005829,0006338,0006468,0006691,0006954,0006974,0009931,0010803,0016310,0018105,0032496,0032675,0032680,0032760,0034097,0035556,0035924,0038066,0043488,0044024,0044351,0048010,0048255,0048839,0051019,0060907,0070062,0070935,0106310,1900034 P49137 12791252 401 QFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKED 1nxk B 2.7 BS01 STU B 1 L70 G71 L72 G73 V78 A91 M138 E139 C140 L141 L193 D207 L27 G28 L29 G30 V35 A48 M95 E96 C97 L98 L150 D164 D186 K188 E190 N191 D207 D143 K145 E147 N148 D164 2.7.11.1 0000165,0002224,0004672,0004674,0004683,0005515,0005516,0005524,0005634,0005654,0005737,0005813,0005829,0006338,0006468,0006691,0006954,0006974,0009931,0010803,0016310,0018105,0032496,0032675,0032680,0032760,0034097,0035556,0035924,0038066,0043488,0044024,0044351,0048010,0048255,0048839,0051019,0060907,0070062,0070935,0106310,1900034 P49137 12791252 403 PQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKED 1nxk C 2.7 BS01 STU C 1 L70 G71 L72 G73 V78 A91 M138 E139 C140 L141 E190 L193 D207 L30 G31 L32 G33 V38 A51 M98 E99 C100 L101 E150 L153 D167 D186 K188 E190 N191 D207 D146 K148 E150 N151 D167 2.7.11.1 0000165,0002224,0004672,0004674,0004683,0005515,0005516,0005524,0005634,0005654,0005737,0005813,0005829,0006338,0006468,0006691,0006954,0006974,0009931,0010803,0016310,0018105,0032496,0032675,0032680,0032760,0034097,0035556,0035924,0038066,0043488,0044024,0044351,0048010,0048255,0048839,0051019,0060907,0070062,0070935,0106310,1900034 P49137 12791252 401 QQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMT 1nxk D 2.7 BS01 STU D 1 L70 G71 L72 G73 V78 A91 M138 E139 C140 L141 D207 L28 G29 L30 G31 V36 A49 M96 E97 C98 L99 D161 D186 K188 E190 N191 D207 T226 D140 K142 E144 N145 D161 T172 2.7.11.1 0000165,0002224,0004672,0004674,0004683,0005515,0005516,0005524,0005634,0005654,0005737,0005813,0005829,0006338,0006468,0006691,0006954,0006974,0009931,0010803,0016310,0018105,0032496,0032675,0032680,0032760,0034097,0035556,0035924,0038066,0043488,0044024,0044351,0048010,0048255,0048839,0051019,0060907,0070062,0070935,0106310,1900034 P49137 12791252 401 FPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVL 1oky A 2.3 BS01 STU A 1 L88 G89 V96 A109 K111 Y161 A162 G165 E166 E209 L212 T222 L17 G18 V25 A38 K40 Y90 A91 G94 E95 E138 L141 T151 D205 K207 E209 N210 D223 T245 D134 K136 E138 N139 D152 T168 2.7.11.1 0004672,0004674,0005524,0006468 ic50=6.5nM -logKd/Ki=8.19, IC50=6.5nM O15530 12892559 1368 PQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPKLT 1q3d A 2.2 BS01 STU A 1 I62 G63 V70 D133 Y134 V135 Q185 L188 D200 I28 G29 V36 D93 Y94 V95 Q145 L148 D160 D181 K183 N186 D200 S219 D141 K143 N146 D160 S179 2.7.11.1,2.7.11.26 0001837,0001954,0002020,0002039,0003170,0004672,0004674,0005515,0005524,0005634,0005654,0005737,0005739,0005813,0005829,0005886,0005977,0006338,0006468,0006983,0007005,0007212,0007399,0007623,0008013,0008286,0009968,0010508,0010628,0010629,0010719,0010975,0016055,0016301,0016310,0018105,0018107,0019082,0019901,0021766,0030010,0030011,0030154,0030336,0030424,0030425,0030516,0030877,0031175,0031333,0031334,0031398,0031625,0032007,0032092,0032436,0032515,0032886,0034236,0034452,0035556,0036016,0042752,0043066,0043161,0043547,0044024,0045597,0045668,0045719,0045724,0045732,0046777,0046825,0046827,0048156,0048511,0048814,0050321,0050770,0051059,0051093,0051128,0060070,0060079,0061629,0070507,0070885,0071109,0071300,0090090,0097191,0097192,0098793,0098794,0098978,0099171,0106027,0106310,0150101,1900034,1900181,1900271,1901030,1901984,1902042,1903566,1904339,1904646,1904781,1904886,1990909,2000077,2000466,2000740 ic50=15nM -logKd/Ki=7.82, IC50=15nM P49841 14529625 451 SKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQ 1q3d B 2.2 BS01 STU B 1 I62 G63 G65 A83 K85 D133 Y134 V135 L188 D200 I28 G29 G31 A49 K51 D95 Y96 V97 L150 D162 D181 K183 N186 D200 S219 D143 K145 N148 D162 S181 2.7.11.1,2.7.11.26 0001837,0001954,0002020,0002039,0003170,0004672,0004674,0005515,0005524,0005634,0005654,0005737,0005739,0005813,0005829,0005886,0005977,0006338,0006468,0006983,0007005,0007212,0007399,0007623,0008013,0008286,0009968,0010508,0010628,0010629,0010719,0010975,0016055,0016301,0016310,0018105,0018107,0019082,0019901,0021766,0030010,0030011,0030154,0030336,0030424,0030425,0030516,0030877,0031175,0031333,0031334,0031398,0031625,0032007,0032092,0032436,0032515,0032886,0034236,0034452,0035556,0036016,0042752,0043066,0043161,0043547,0044024,0045597,0045668,0045719,0045724,0045732,0046777,0046825,0046827,0048156,0048511,0048814,0050321,0050770,0051059,0051093,0051128,0060070,0060079,0061629,0070507,0070885,0071109,0071300,0090090,0097191,0097192,0098793,0098794,0098978,0099171,0106027,0106310,0150101,1900034,1900181,1900271,1901030,1901984,1902042,1903566,1904339,1904646,1904781,1904886,1990909,2000077,2000466,2000740 ic50=15nM -logKd/Ki=7.82, IC50=15nM P49841 14529625 452 SKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHAR 1qpd A 2.0 BS01 STU A 1 L251 A271 K273 T316 Y318 M319 G322 S323 L371 L21 A41 K43 T86 Y88 M89 G92 S93 L141 D364 R366 A368 N369 D382 A400 F402 D134 R136 A138 N139 D152 A170 F172 2.7.10.2 0004672,0004713,0005524,0006468 P06239 10404594 902 KPWWEDAWEVPRETLKLVERLGAGQAGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDAEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTAT 1qpj A 2.2 BS01 STU A 1 L251 A271 K273 Y318 M319 G322 S323 A368 L371 D382 L16 A36 K38 Y83 M84 G87 S88 A133 L136 D147 D364 R366 A368 N369 D382 A400 F402 D129 R131 A133 N134 D147 A165 F167 2.7.10.2 0004672,0004713,0005524,0006468 P06239 10404594 902 DEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTAT 1sm2 A 2.3 BS01 STU A 1 I369 G370 V377 A389 K391 F435 F437 M438 G441 R486 L489 D500 I13 G14 V21 A33 K35 F79 F81 M82 G85 R130 L133 D144 D482 A484 R486 N487 D500 P521 D126 A128 R130 N131 D144 P147 2.7.10.2 0004672,0004713,0004715,0005524,0006468 Ki<10nM -logKd/Ki=8.00, Ki<10nM Q08881 14766749 301 VIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFSRLLRQLAEIAESG 1sm2 B 2.3 BS01 STU B 1 I369 G370 V377 A389 K391 F435 E436 F437 M438 G441 R486 L489 D500 I12 G13 V20 A32 K34 F78 E79 F80 M81 G84 R129 L132 D143 D482 A484 R486 N487 D500 P521 D125 A127 R129 N130 D143 P145 2.7.10.2 0004672,0004713,0004715,0005524,0006468 Ki<10nM Q08881 14766749 621 IDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFSRLLRQLAEIAE 1snu A 2.5 BS01 STU A 1 I369 V377 A389 F435 F437 M438 G441 C442 R486 L489 D500 I13 V21 A33 F79 F81 M82 G85 C86 R130 L133 D144 D482 A484 R486 N487 D500 P521 D126 A128 R130 N131 D144 P147 2.7.10.2 0004672,0004713,0004715,0005524,0006468 Q08881 14766749 301 VIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFSRLLRQLAEIAESG 1snu B 2.5 BS01 STU B 1 I369 V377 A389 K391 F435 E436 F437 M438 G441 C442 R486 N487 L489 D500 I12 V20 A32 K34 F78 E79 F80 M81 G84 C85 R129 N130 L132 D143 D482 A484 R486 N487 D500 P521 D125 A127 R129 N130 D143 P145 2.7.10.2 0004672,0004713,0004715,0005524,0006468 Q08881 14766749 621 IDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFSRLLRQLAEIAE 1stc E 2.3 BS02 STU E 1 L49 G50 V57 A70 M120 Y122 V123 G126 E127 E170 N171 L173 T183 D184 F327 L35 G36 V43 A56 M106 Y108 V109 G112 E113 E156 N157 L159 T169 D170 F313 D166 K168 N171 D184 T201 D152 K154 N157 D170 T187 2.7.11.11 0001669,0001707,0004672,0004674,0004679,0004691,0005515,0005524,0005634,0005737,0005739,0005829,0005886,0005952,0006468,0010737,0016310,0018105,0019904,0031594,0034237,0034605,0036126,0048471,0106310,1904262 Ki=8nM -logKd/Ki=8.10, Ki=8nM P00517 9438863 351 VKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHMETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF 1u59 A 2.3 BS01 STU A 1 L344 G345 V352 A367 M414 M416 A417 G420 P421 R465 N466 L468 D479 L17 G18 V25 A37 M84 M86 A87 G90 P91 R135 N136 L138 D149 D461 A463 R465 N466 D479 W501 D131 A133 R135 N136 D149 W171 2.7.10.2 0004672,0004713,0005524,0006468 ic50=55.8nM -logKd/Ki=7.25, IC50=55.8nM P43403 15292186 100 KKLFLKRDNLLIADIELGCGNFGSVRQGVYRKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGHHHHHH 1wvy A 2.8 BS01 STU A 1 L19 G20 V27 A40 K42 L95 V96 E143 I160 D161 L16 G17 V24 A37 K39 L92 V93 E140 I157 D158 D139 K141 E143 N144 D161 T180 D136 K138 E140 N141 D158 T177 2.7.11.1 0004672,0005524,0006468 P53355 1001 FRQENVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEIQHPNVITLHEVYENKTDVILILELVAGGELFDFLAEKESLTEEEATEFLKQILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNTSALAKDFIRRLLVKDPKKRMTIQDSLQHPWIK 1xbc A 2.0 BS01 STU A 1 L377 G378 A400 M448 M450 A451 G454 P455 R498 N499 L501 D512 L15 G16 A38 M80 M82 A83 G86 P87 R130 N131 L133 D144 D494 A496 R498 N499 D512 K533 D126 A128 R130 N131 D144 K165 2.7.10.2 0004672,0004713,0005524,0006468 ic50=0.012uM -logKd/Ki=7.92, IC50=0.012uM P43405 15507431 1 VYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVNE 1xjd A 2.0 BS01 STU A 1 L386 G387 K388 G389 V394 A407 M458 E459 Y460 L461 G464 D465 D508 N509 L511 D522 L10 G11 K12 G13 V18 A31 M82 E83 Y84 L85 G88 D89 D132 N133 L135 D146 D504 K506 D508 N509 D522 T542 D128 K130 D132 N133 D146 T166 2.7.11.13 0004672,0004674,0004697,0005524,0006468 Ki=0.33nM -logKd/Ki=9.48, Ki=0.33nM Q04759 15364937 200 IEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFREINWEELERKEIDPQNMFRNFSF 1yhs A 2.15 BS01 STU A 1 L44 G45 F49 V52 A65 L120 E121 R122 V126 D128 E171 L174 I185 D186 L12 G13 F17 V20 A33 L84 E85 R86 V90 D92 E135 L138 I149 D150 D167 K169 N172 D186 L193 T204 D131 K133 N136 D150 L157 T168 2.7.11.1 0004672,0004674,0005524,0006468,0043066 ic50=0.01uM -logKd/Ki=8.00, IC50=0.01uM P11309 15657054 306 PLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGETRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLH 2buj A 2.6 BS01 STU A 1 L26 E28 V34 A47 F100 F101 M165 L22 E24 V28 A41 F94 F95 M159 D148 K150 N153 D166 T195 D142 K144 N147 D160 T189 2.7.10.2,2.7.11.1 0000978,0004672,0004674,0004713,0004715,0005515,0005524,0005654,0005737,0005794,0005798,0005829,0005886,0006338,0006468,0016020,0016310,0044024,0045944,0046777,0048471,0071560,0106310 O75716 1301 NLYFQGHMVIIDNKHYLFIQKLGEFSYVDLVEGLHDGHFYALKRILCHEQQDREEAQREADMHRLFNHPNILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQILWLLLGICRGLEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTLQDWAAQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPYDMVFQKGDSVALAVQNQIPQSPRHSSALWQLLNSMMTVDPHQRPHIPLLLSQLEALQPPAPG 2buj A 2.6 BS02 STU A 2 E87 H92 E81 H86 D148 K150 N153 D166 T195 D142 K144 N147 D160 T189 2.7.10.2,2.7.11.1 0000978,0004672,0004674,0004713,0004715,0005515,0005524,0005654,0005737,0005794,0005798,0005829,0005886,0006338,0006468,0016020,0016310,0044024,0045944,0046777,0048471,0071560,0106310 O75716 1302 NLYFQGHMVIIDNKHYLFIQKLGEFSYVDLVEGLHDGHFYALKRILCHEQQDREEAQREADMHRLFNHPNILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQILWLLLGICRGLEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTLQDWAAQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPYDMVFQKGDSVALAVQNQIPQSPRHSSALWQLLNSMMTVDPHQRPHIPLLLSQLEALQPPAPG 2buj B 2.6 BS01 STU B 1 L26 E28 V34 A47 F100 M165 L23 E25 V31 A44 F93 M158 D148 K150 N153 D166 T195 D141 K143 N146 D159 T188 2.7.10.2,2.7.11.1 0000978,0004672,0004674,0004713,0004715,0005515,0005524,0005654,0005737,0005794,0005798,0005829,0005886,0006338,0006468,0016020,0016310,0044024,0045944,0046777,0048471,0071560,0106310 O75716 1299 ENLYFQGHMVIIDNKHYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRILCHEQQDREEAQREADMHRLFNHPNILRLVAYCLREHEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQILWLLLGICRGLEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTLQDWAAQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPYDMVFQKGDSVALAVQNQLSPRHSSALWQLLNSMMTVDPHQRPHIPLLLSQLEALQPPA 2buj B 2.6 BS02 STU B 2 F45 F100 K102 R103 G104 F42 F93 K95 R96 G97 D148 K150 N153 D166 T195 D141 K143 N146 D159 T188 2.7.10.2,2.7.11.1 0000978,0004672,0004674,0004713,0004715,0005515,0005524,0005654,0005737,0005794,0005798,0005829,0005886,0006338,0006468,0016020,0016310,0044024,0045944,0046777,0048471,0071560,0106310 O75716 1300 ENLYFQGHMVIIDNKHYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRILCHEQQDREEAQREADMHRLFNHPNILRLVAYCLREHEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQILWLLLGICRGLEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTLQDWAAQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPYDMVFQKGDSVALAVQNQLSPRHSSALWQLLNSMMTVDPHQRPHIPLLLSQLEALQPPA 2clq A 2.3 BS01 STU A 1 L686 G687 V694 A707 M754 E755 Q756 V757 D807 L810 S821 L17 G18 V25 A38 M82 E83 Q84 V85 D135 L138 S149 D803 K805 D807 N808 D822 T842 D131 K133 D135 N136 D150 T165 2.7.11.25 0004672,0005524,0006468 Q99683 17937911 1941 LLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSQPLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLLVDEFLKV 2clq B 2.3 BS01 STU B 1 L686 G687 V694 A707 M754 E755 Q756 V757 D807 L810 S821 L17 G18 V25 A38 M81 E82 Q83 V84 D134 L137 S148 D803 K805 D807 N808 D822 T842 D130 K132 D134 N135 D149 T161 2.7.11.25 0004672,0005524,0006468 Q99683 17937911 1941 LLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERSQPLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLLVDEFLKV 2dq7 X 2.8 BS01 STU X 1 L17 V25 A37 K39 T82 Y84 M85 G88 A134 L137 D148 L17 V25 A37 K39 T82 Y84 M85 G88 A134 L137 D148 N135 D148 N135 D148 2.7.10.2 0004672,0004713,0005524,0006468 -logKd/Ki=8.32, IC50=4.8nM P06241 16782058 902 KDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDY 2gcd A 2.55 BS01 STU A 1 I34 V42 A55 M105 Y107 C108 L109 G110 G155 L158 D169 K314 I23 V31 A44 M94 Y96 C97 L98 G99 G144 L147 D158 K303 D151 K153 G155 N156 D169 P178 T185 D140 K142 G144 N145 D158 P167 T174 2.7.11.1 0004672,0005524,0006468 -logKd/Ki=5.52, IC50=3uM Q9JLS3 16761096 400 DPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPALQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDAVRELDNLQYRKMKKILFQEA 2gcd B 2.55 BS01 STU B 1 I34 V42 A55 K57 M105 E106 Y107 C108 L109 G110 G155 N156 D169 K314 I23 V31 A44 K46 M94 E95 Y96 C97 L98 G99 G144 N145 D158 K303 D151 K153 G155 N156 D169 P178 T185 D140 K142 G144 N145 D158 P167 T174 2.7.11.1 0004672,0005524,0006468 Q9JLS3 16761096 500 DPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPALQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDAVRELDNLQYRKMKKILFQEA 2hw7 A 2.71 BS01 STU A 1 L90 G91 E92 A111 K113 E160 K161 M162 G165 E209 L21 G22 E23 A42 K44 E91 K92 M93 G96 E140 D205 K207 N210 D226 S253 D136 K138 N141 D157 S161 2.7.11.1 0004672,0005524,0006468 Q9HBH9 16917500 31 GSTDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFGGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCCGACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQGC 2nry A 2.15 BS01 STU A 1 M192 E194 V200 A211 K213 Y262 V263 Y264 M265 G268 A315 N316 L318 S328 M29 E31 V37 A48 K50 Y96 V97 Y98 M99 G102 A149 N150 L152 S162 D311 K313 A315 N316 D329 T351 D145 K147 A149 N150 D163 T180 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 Q9NWZ3 17161373 504 RFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMT 2nry B 2.15 BS01 STU B 1 M192 G195 V200 A211 K213 Y262 V263 Y264 M265 G268 A315 L318 M29 G32 V37 A48 K50 Y96 V97 Y98 M99 G102 A149 L152 D311 K313 A315 N316 D329 T351 D145 K147 A149 N150 D163 T180 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 Q9NWZ3 17161373 502 RFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMT 2nry C 2.15 BS01 STU C 1 M192 G193 E194 V200 A211 K213 Y262 V263 Y264 M265 G268 A315 L318 M29 G30 E31 V37 A48 K50 Y89 V90 Y91 M92 G95 A142 L145 D311 K313 A315 N316 D329 T351 D138 K140 A142 N143 D156 T174 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 Q9NWZ3 17161373 503 RFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLLKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMT 2nry D 2.15 BS01 STU D 1 E194 V200 A211 Y262 V263 Y264 M265 G268 A315 N316 L318 E31 V37 A48 Y90 V91 Y92 M93 G96 A143 N144 L146 D311 K313 A315 N316 D329 T351 D139 K141 A143 N144 D157 T174 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 Q9NWZ3 17161373 501 RFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 2oic A 2.4 BS01 STU A 1 M192 E194 G195 V200 A211 Y264 M265 G268 A315 N316 L318 M30 E32 G33 V38 A49 Y91 M92 G95 A142 N143 L145 D311 K313 A315 N316 D329 T351 D138 K140 A142 N143 D156 T172 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 ic50=4nM -logKd/Ki=8.40, IC50=4nM Q9NWZ3 17312103 1 TRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARATVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMT 2oic B 2.4 BS01 STU B 1 M192 A211 Y264 M265 G268 A315 L318 M29 A46 Y89 M90 G93 A140 L143 D311 K313 A315 N316 D329 T351 D136 K138 A140 N141 D154 T170 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 ic50=4nM Q9NWZ3 17312103 2 RFHSFSFYELKNVTNNFDERPISVGGNKMGEGGVVYKGYVNNTTVAVKKLLKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTA 2oic C 2.4 BS01 STU C 1 M192 G195 A211 Y262 Y264 M265 G268 A315 N316 L318 M32 G35 A51 Y94 Y96 M97 G100 A147 N148 L150 D311 K313 A315 N316 D329 T351 D143 K145 A147 N148 D161 T173 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 ic50=4nM Q9NWZ3 17312103 3 SDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMT 2oic D 2.4 BS01 STU D 1 G193 V200 A211 K213 Y262 Y264 M265 G268 A315 L318 S328 G33 V40 A51 K53 Y92 Y94 M95 G98 A145 L148 S158 D311 K313 A315 N316 D329 T351 D141 K143 A145 N146 D159 T179 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 ic50=4nM Q9NWZ3 17312103 4 SDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLLKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTA 2pzy C 2.9 BS01 STU C 1 L70 G71 L72 G73 A91 M138 C140 L141 E190 N191 L193 T206 D207 L29 G30 L31 G32 A50 M97 C99 L100 E149 N150 L152 T165 D166 D186 K188 E190 N191 D207 D145 K147 E149 N150 D166 2.7.11.1 0004672,0005524,0006468 P49137 17576063 3 QFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSA 2yn8 A 2.11 BS01 STU A 1 I621 A645 K647 T693 F695 M696 G699 R744 L747 D758 I14 A33 K35 T81 F83 M84 G87 R132 L135 D146 D740 A742 R744 N745 D758 P783 D128 A130 R132 N133 D146 P148 2.7.10.1 0004672,0004713,0005524,0006468 P54760 23840071 1889 KEIDVSYVKIEEVIGAGEFGEVCRGRLKESCVAIKTLKGGYTERQRREFLSEASIMGQFEHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCPTSLHQLMLDCWQKDRNARPRFPQIVSALDKMIRNPASLKIVA 2yn8 B 2.11 BS01 STU B 1 I621 V629 A645 K647 T693 E694 F695 M696 G699 R744 L747 D758 I16 V24 A40 K42 T88 E89 F90 M91 G94 R139 L142 D153 D740 A742 R744 N745 D758 P783 D135 A137 R139 N140 D153 P155 2.7.10.1 0004672,0004713,0005524,0006468 P54760 23840071 1889 FAKEIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMGQFEHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCPTSLHQLMLDCWQKDRNARPRFPQIVSALDKMIRNPASLKIVA 2z7r A 2.0 BS01 STU A 1 L68 G69 A92 K94 D142 F143 L144 D148 E191 N192 L194 T204 L16 G17 A40 K42 D79 F80 L81 D85 E128 N129 L131 T141 D187 K189 E191 N192 D205 T225 D124 K126 E128 N129 D142 T150 2.7.11.1 0004672,0004674,0005524,0006468 ic50~0.4nM -logKd/Ki=9.52, IC50=0.3nM Q15418 17965187 1 GSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKP 3a4o X 3.0 BS01 STU X 1 L22 V30 K44 E89 Y90 M91 G94 A140 L143 L16 V24 K38 E83 Y84 M85 G88 A134 L137 N141 D154 N135 D148 2.7.10.2 0004672,0004713,0005524,0006468 -logKd/Ki=8.89, IC50=1.3nM P07948 19857964 902 DAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVEGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFYTATE 3a60 A 2.8 BS01 STU A 1 L97 G100 V105 A121 K123 Y174 L175 E179 M225 T235 D236 L13 G16 V21 A37 K39 Y79 L80 E84 M130 T140 D141 D218 K220 E222 N223 D236 T256 D123 K125 E127 N128 D141 T148 2.7.11.1 0004672,0004674,0005524,0006468 P23443 19864428 400 KIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKETIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKP 3a60 B 2.8 BS01 STU B 1 L97 G100 V105 A121 K123 L172 E173 Y174 L175 G178 E179 E222 M225 T235 F237 L13 G16 V21 A37 K39 L65 E66 Y67 L68 G71 E72 E115 M118 T128 F130 D218 K220 E222 N223 D236 T256 D111 K113 E115 N116 D129 T139 2.7.11.1 0004672,0004674,0005524,0006468 P23443 19864428 401 KIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPL 3a61 A 3.43 BS01 STU A 1 L97 A121 Y174 L175 E179 N223 M225 T235 D236 L11 A35 Y73 L74 E78 N122 M124 T134 D135 D218 K220 E222 N223 D236 T256 D117 K119 E121 N122 D135 T139 2.7.11.1 0004672,0004674,0005524,0006468 P23443 19864428 400 RPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKP 3a62 A 2.35 BS01 STU A 1 L97 V105 A121 E173 Y174 L175 E179 E222 M225 T235 D236 L13 V21 A37 E75 Y76 L77 E81 E124 M127 T137 D138 D218 K220 E222 N223 D236 T256 D120 K122 E124 N125 D138 T148 2.7.11.1 0004672,0004674,0005524,0006468 P23443 19864428 400 KIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPL 3bkb A 1.78 BS01 STU A 1 I567 G568 R569 V575 A588 E607 E637 L638 V639 G642 R687 L690 S700 D701 I119 G120 R121 V127 A140 E159 E189 L190 V191 G194 R239 L242 S252 D253 D683 A685 R687 N688 D701 G718 D235 A237 R239 N240 D253 G270 2.7.10.2 0004672,0004713,0005524,0006468 P07332 18775312 826 PEVQKPLHEQLWYHGAIPRAEVAELLVHSGDFLVRESQGKQEYVLSVLWDGLPRHFIIQSLDNLYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRH 3cbl A 1.75 BS02 STU A 1 I567 R569 A588 E607 E637 L638 V639 G642 R687 L690 S700 D701 I102 R104 A123 E142 E172 L173 V174 G177 R222 L225 S235 D236 D683 A685 R687 N688 D701 G718 D218 A220 R222 N223 D236 G253 2.7.10.2 0004672,0004713,0005524,0006468 P07332 18775312 901 SMIPEVQKPLHEQLWYHGAIPRAEVAELLVHSGDFLVRESQQEYVLSVPRHFIINLYRLFPSIPLLIDHLLSTQQPLVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRH 3cbl A 1.75 BS03 STU A 2 D583 T585 R621 L622 I623 D118 T120 R156 L157 I158 D683 A685 R687 N688 D701 G718 D218 A220 R222 N223 D236 G253 2.7.10.2 0004672,0004713,0005524,0006468 P07332 18775312 902 SMIPEVQKPLHEQLWYHGAIPRAEVAELLVHSGDFLVRESQQEYVLSVPRHFIINLYRLFPSIPLLIDHLLSTQQPLVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRH 3cbl A 1.75 BS04 STU A 3 H456 E559 R581 H11 E94 R116 D683 A685 R687 N688 D701 G718 D218 A220 R222 N223 D236 G253 2.7.10.2 0004672,0004713,0005524,0006468 P07332 18775312 903 SMIPEVQKPLHEQLWYHGAIPRAEVAELLVHSGDFLVRESQQEYVLSVPRHFIINLYRLFPSIPLLIDHLLSTQQPLVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRH 3cd3 A 1.98 BS02 STU A 1 I567 R569 A588 E607 E637 L638 V639 G642 D643 R687 L690 S700 D701 I103 R105 A124 E139 E169 L170 V171 G174 D175 R219 L222 S232 D233 D683 A685 R687 N688 D701 G718 D215 A217 R219 N220 D233 G250 2.7.10.2 0004672,0004713,0005524,0006468 P07332 18775312 901 SMIPEVQKPLHEQLWYHGAIPRAEVAELLVHSGDFLVRESQEYVLSVPRHFIINLYRLFPSIPLLIDHLLSTQQPLSGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRH 3cd3 A 1.98 BS03 STU A 2 D583 T585 R621 L622 I623 D119 T121 R153 L154 I155 D683 A685 R687 N688 D701 G718 D215 A217 R219 N220 D233 G250 2.7.10.2 0004672,0004713,0005524,0006468 P07332 18775312 902 SMIPEVQKPLHEQLWYHGAIPRAEVAELLVHSGDFLVRESQEYVLSVPRHFIINLYRLFPSIPLLIDHLLSTQQPLSGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRH 3cd3 A 1.98 BS04 STU A 3 H456 E559 R581 H11 E95 R117 D683 A685 R687 N688 D701 G718 D215 A217 R219 N220 D233 G250 2.7.10.2 0004672,0004713,0005524,0006468 P07332 18775312 903 SMIPEVQKPLHEQLWYHGAIPRAEVAELLVHSGDFLVRESQEYVLSVPRHFIINLYRLFPSIPLLIDHLLSTQQPLSGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRH 3ckx A 2.7 BS01 STU A 1 I15 K17 V23 A36 M84 E85 Y86 L87 G90 S91 A133 L136 D147 I11 K13 V19 A32 M78 E79 Y80 L81 G84 S85 A127 L130 D141 D129 K131 A133 N134 D147 D156 T167 D123 K125 A127 N128 D141 D150 T161 2.7.11.1 0004672,0005524,0006468 Q9Y6E0 305 PEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEDEIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQ 3d7t A 2.899 BS01 STU A 1 I201 G202 V209 A220 K222 T266 M269 S273 R318 L321 S331 I14 G15 V22 A33 K35 T79 M82 S86 R131 L134 S144 D314 A316 R318 N319 D332 P349 D127 A129 R131 N132 D145 P148 2.7.10.2 0004672,0004713,0005524,0006468 P41240 18614016 6335 WALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGPVKWTAPEALREAAFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQLEHIKTHELHL 3d7t B 2.899 BS01 STU B 1 L273 A293 K295 Y340 M341 G344 L393 F405 L16 A36 K38 Y83 M84 G87 L136 F148 D386 R388 A390 N391 D404 F424 D129 R131 A133 N134 D147 F156 2.7.10.2 0004672,0004713,0005524,0006468 P00523 18614016 6334 DAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 3fme A 2.26 BS01 STU A 1 L59 A80 M129 E130 L131 M132 D133 T134 S135 S183 L186 C196 L14 A35 M81 E82 L83 M84 D85 T86 S87 S135 L138 C148 D179 K181 S183 N184 D197 C216 D131 K133 S135 N136 D149 C153 2.7.12.2 0004672,0005524,0006468 P52564 1 MEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFAGCKPYMAPERINPELNQYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFVKLILG 3hmo A 2.4 BS01 STU A 1 I531 G532 V539 A551 K553 C604 G605 N606 D608 L654 I18 G19 V26 A38 K40 C91 G92 N93 D95 L141 N556 L565 D647 K649 N652 D664 T686 N43 L52 D134 K136 N139 D151 T161 2.7.12.1 0004672,0005524,0005975,0006468 Kd=30.5nM -logKd/Ki=7.52, Kd=30.5nM P33981 20099905 1 ANECISVKGRIYSILKQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGMLKLIDFGIANQMVGTVNYMPPEAIKDMISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQ 3lcs A 1.95 BS01 STU A 1 L1122 V1130 A1148 K1150 L1198 M1199 G1202 D1203 L1256 L27 V35 A53 K55 L103 M104 G107 D108 L161 D1249 A1251 R1253 N1254 D1270 R1279 D154 A156 R158 N159 D175 R184 2.7.10.1 0004672,0004713,0004714,0005524,0006468,0007169,0016020 Q9UM73 20632993 1 YCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRAGYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPI 3p86 A 2.496 BS01 STU A 1 I557 G558 A559 F562 V565 A576 T625 Y627 L628 G631 P680 L683 C693 I14 G15 A16 F19 V22 A33 T82 Y84 L85 G88 P137 L140 C150 N676 K678 P680 N681 D694 T714 N133 K135 P137 N138 D151 T154 2.7.11.1 0004672,0005524,0006468 Q05609 22155294 0 MDIPWCDLNIKEKIGAGSFGTVHRAEWHGSDVAVKILMEQDFHAERVNEFLREVAIMKRLRHPNIVLFMGAVTQPPNLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMNYLHNRNPPIVHRNLKSPNLLVDKKYTVKVCDFGTPEWMAPEVLRDEPSNEKSDVYSFGVILWELATLQQPWGNLNPAQVVAAVGFKCKRLEIPRNLNPQVAAIIEGCWTNEPWKRPSFATIMDLLRPLIK 3ppz A 2.99 BS01 STU A 1 I557 G558 V565 A576 K578 T625 Y627 L628 G631 R635 P680 L683 C693 D694 I18 G19 V26 A37 K39 T82 Y84 L85 G88 R92 P137 L140 C150 D151 D676 K678 P680 N681 D694 T714 D133 K135 P137 N138 D151 T171 2.7.11.1 0004672,0005524,0006468 Q05609 22155294 1 DGDDMDIPWCDLNIKEKIGAGSFGTVHRAEWHGSDVAVKILMEAERVNEFLREVAIMKRLRHPNIVLFMGAVTQPPNLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMNYLHNRNPPIVHRDLKSPNLLVDKKYTVKVCDFGLSRLKASTFLSSKSAAGTPEWMAPEVLRDEPSNEKSDVYSFGVILWELATLQQPWGNLNPAQVVAAVGFKCKRLEIPRNLNPQVAAIIEGCWTNEPWKRPSFATIMDLLRPLIK 3s95 A 1.65 BS01 STU A 1 L345 V366 K368 E384 L397 E414 Y415 I416 G419 H464 N465 L467 L18 V39 K41 E57 L70 E87 Y88 I89 G92 H137 N138 L140 D460 N462 H464 N465 D478 N512 D133 N135 H137 N138 D151 N165 2.7.11.1 0004672,0005524,0006468 P53667 1 SMPHRIFRPSDLIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKNVVVADFGLARLMVYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSFVKLEHWLETLRMHLAGHLPLGPQLEQLDRGFWETYRRGES 3s95 B 1.65 BS01 STU B 1 L345 G346 A353 V366 K368 E384 L397 T413 E414 Y415 I416 G419 H464 L467 L18 G19 A26 V39 K41 E57 L70 T86 E87 Y88 I89 G92 H137 L140 D460 N462 H464 N465 D478 N512 D133 N135 H137 N138 D151 N165 2.7.11.1 0004672,0005524,0006468 P53667 1 SMPHRIFRPSDLIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKNVVVADFGLARLMVYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSFVKLEHWLETLRMHLAGHLPLGPQLEQLDRGFWETYRRGES 3zew A 2.5 BS01 STU A 1 I621 G622 V629 A645 F695 M696 G699 R744 L747 S757 D758 I13 G14 V21 A37 F83 M84 G87 R132 L135 S145 D146 D740 A742 R744 N745 D758 K781 P783 D128 A130 R132 N133 D146 K163 P165 2.7.10.1 0004672,0004713,0005524,0006468 P54760 24677421 1889 EIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLTERQRREFLSEASIMGQFEHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLSSDPTYTSSKIPIRWTAPEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCPTSLHQLMLDCWQKDRNARPRFPQVVSALDKMIRNPASLKIVA 3zew B 2.5 BS01 STU B 1 I621 G622 A645 T693 E694 F695 M696 G699 R744 L747 D758 I13 G14 A35 T79 E80 F81 M82 G85 R130 L133 D144 D740 A742 R744 N745 D758 P783 D126 A128 R130 N131 D144 P148 2.7.10.1 0004672,0004713,0005524,0006468 P54760 24677421 1888 EIDVSYVKIEEVIGAGEFGEVCRGRLKAKKESCVAIKTLTERQRREFLSEASIMGQFEHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGIPIRWTAPEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCPTSLHQLMLDCWQKDRNARPRFPQVVSALDKMIRNPASLKIV 4bf2 A 2.11 BS01 STU A 1 L686 G687 K688 V694 A707 M754 E755 Q756 V757 D807 L810 S821 D822 L16 G17 K18 V24 A37 M74 E75 Q76 V77 D127 L130 S141 D142 D803 K805 D807 N808 D822 T842 D123 K125 D127 N128 D142 T156 2.7.11.25 0004672,0005524,0006468 Q99683 23776076 1940 LEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPEEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAEEFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLLVDEFLK 4bf2 B 2.11 BS01 STU B 1 L686 G689 V694 A707 M754 Q756 V757 D807 L810 S821 D822 L16 G19 V24 A37 M75 Q77 V78 D128 L131 S142 D143 D803 K805 D807 N808 D822 T842 D124 K126 D128 N129 D143 T154 2.7.11.25 0004672,0005524,0006468 Q99683 23776076 1941 LEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPEREEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLATGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLLVDEFLKV 4c34 A 1.78 BS02 STU A 1 L49 V57 A70 K72 Y122 L123 E127 E170 M173 T183 F327 L40 V48 A61 K63 Y113 L114 E118 E161 M164 T174 F317 D166 K168 E170 N171 D184 T201 D157 K159 E161 N162 D175 T192 2.7.11.11 0001669,0001707,0004672,0004674,0004679,0004691,0005515,0005524,0005634,0005737,0005739,0005829,0005886,0005952,0006468,0010737,0016310,0018105,0019904,0031594,0034237,0034605,0036126,0048471,0106310,1904262 P00517 24072592 1351 SEQESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSYGRVMLVKHMETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVLEYLPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLMIDQQGYIKVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF 4cfe A 3.023 BS01 STU A 1 L22 G23 G25 V30 A43 E94 Y95 V96 E100 E143 N144 L146 D157 L15 G16 G18 V23 A36 E87 Y88 V89 E93 E136 N137 L139 D150 D139 K141 E143 N144 D157 S176 D132 K134 E136 N137 D150 S169 2.7.11.1,2.7.11.31 0003682,0004672,0004674,0004679,0004712,0005515,0005524,0005634,0005654,0005737,0005794,0005829,0006325,0006338,0006468,0006633,0006695,0006914,0007165,0008610,0010468,0010494,0010508,0010629,0014850,0016055,0016239,0016241,0016310,0016607,0030424,0030425,0031588,0031669,0032007,0034599,0042149,0042593,0042752,0043025,0043066,0044024,0045821,0046872,0047322,0048511,0055089,0062028,0070507,0071277,0071333,0071380,0071466,0097009,0106310,0140823,1903829,1903944,1904262,1904428,1905691,1990044,2000758 P54646 24352254 1552 DGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEAVAYHLIIDNRRIMNQASEFYLASSPLKPHPERMPPLIADAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDLGSHTMDFFEMCASLITTLA 4cfe C 3.023 BS01 STU C 1 L22 G25 V30 A43 E94 Y95 V96 E100 E143 N144 L146 D157 L13 G16 V21 A34 E85 Y86 V87 E91 E134 N135 L137 D148 D139 K141 E143 N144 D157 S176 D130 K132 E134 N135 D148 S167 2.7.11.1,2.7.11.31 0003682,0004672,0004674,0004679,0004712,0005515,0005524,0005634,0005654,0005737,0005794,0005829,0006325,0006338,0006468,0006633,0006695,0006914,0007165,0008610,0010468,0010494,0010508,0010629,0014850,0016055,0016239,0016241,0016310,0016607,0030424,0030425,0031588,0031669,0032007,0034599,0042149,0042593,0042752,0043025,0043066,0044024,0045821,0046872,0047322,0048511,0055089,0062028,0070507,0071277,0071333,0071380,0071466,0097009,0106310,0140823,1903829,1903944,1904262,1904428,1905691,1990044,2000758 P54646 24352254 1552 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDIIDNRRIMNQASEFYLASSPLKPHPERMPPLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDLGSHTMDFFEMCASLITTLA 4cff A 3.924 BS01 STU A 1 L22 G23 G25 V30 A43 K45 E94 Y95 V96 E100 E143 N144 L146 D157 L15 G16 G18 V23 A36 K38 E87 Y88 V89 E93 E136 N137 L139 D150 D139 K141 E143 N144 D157 S176 D132 K134 E136 N137 D150 S169 2.7.11.1,2.7.11.31 0003682,0004672,0004674,0004679,0004712,0005515,0005524,0005634,0005654,0005737,0005794,0005829,0006325,0006338,0006468,0006633,0006695,0006914,0007165,0008610,0010468,0010494,0010508,0010629,0014850,0016055,0016239,0016241,0016310,0016607,0030424,0030425,0031588,0031669,0032007,0034599,0042149,0042593,0042752,0043025,0043066,0044024,0045821,0046872,0047322,0048511,0055089,0062028,0070507,0071277,0071333,0071380,0071466,0097009,0106310,0140823,1903829,1903944,1904262,1904428,1905691,1990044,2000758 P54646 24352254 1552 DGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEAVAYHLIIDNRRIMNQASEFYLASSPLKPHPERMPPLIAAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDLGSHTMDFFEMCASLITTLA 4cff C 3.924 BS01 STU C 1 L22 G23 V24 G25 V30 A43 K45 V96 E100 E143 N144 L146 D157 L13 G14 V15 G16 V21 A34 K36 V87 E91 E134 N135 L137 D148 D139 K141 E143 N144 D157 S176 D130 K132 E134 N135 D148 S167 2.7.11.1,2.7.11.31 0003682,0004672,0004674,0004679,0004712,0005515,0005524,0005634,0005654,0005737,0005794,0005829,0006325,0006338,0006468,0006633,0006695,0006914,0007165,0008610,0010468,0010494,0010508,0010629,0014850,0016055,0016239,0016241,0016310,0016607,0030424,0030425,0031588,0031669,0032007,0034599,0042149,0042593,0042752,0043025,0043066,0044024,0045821,0046872,0047322,0048511,0055089,0062028,0070507,0071277,0071333,0071380,0071466,0097009,0106310,0140823,1903829,1903944,1904262,1904428,1905691,1990044,2000758 P54646 24352254 1552 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVAYHLIIDNRRIMNQASEFYLASSPLKPHPERMPPLIADAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDLGSHTMDFFEMCASLITTLA 4cfh A 3.24 BS02 STU A 1 L22 G23 G25 A43 K45 M93 E94 Y95 V96 G99 E100 E143 N144 L146 D157 L13 G14 G16 A34 K36 M84 E85 Y86 V87 G90 E91 E134 N135 L137 D148 D139 K141 E143 N144 D157 S176 D130 K132 E134 N135 D148 S167 2.7.11.1,2.7.11.26,2.7.11.31 0004672,0005524,0006468 P54645 21399626 1550 RVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRAAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTFSKMSLQLYQVDSRTYLLDFRSIDDEI 4erw A 2.0 BS01 STU A 1 I10 V18 A31 K33 F80 E81 F82 L83 Q131 L134 D145 I10 V18 A31 K33 F75 E76 F77 L78 Q126 L129 D140 D127 K129 Q131 N132 D145 T158 T165 D122 K124 Q126 N127 D140 T153 T160 2.7.11.22 0000082,0000086,0000122,0000287,0000307,0000781,0000793,0000805,0000806,0001673,0004672,0004674,0004693,0005515,0005524,0005634,0005635,0005654,0005667,0005737,0005768,0005813,0005829,0005856,0006260,0006281,0006338,0006351,0006468,0006813,0007099,0007165,0007265,0007346,0008284,0010389,0010468,0015030,0016301,0016310,0018105,0019904,0030332,0031453,0031571,0032298,0035173,0043247,0043687,0045740,0045893,0046872,0051298,0051301,0051321,0071732,0090398,0097123,0097124,0097134,0097135,0097472,0106310,1905784 -logKd/Ki=8.15, IC50=7nM P24941 22893598 301 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 4ez7 A 2.49 BS01 STU A 1 I10 G11 E12 G13 V18 A31 K33 E81 F82 L83 H84 Q131 N132 L134 D145 I14 G15 E16 G17 V22 A35 K37 E85 F86 L87 H88 Q135 N136 L138 D149 D127 K129 Q131 N132 D145 T158 T165 D131 K133 Q135 N136 D149 T162 T169 2.7.11.22 0000082,0000086,0000122,0000287,0000307,0000781,0000793,0000805,0000806,0001673,0004672,0004674,0004693,0005515,0005524,0005634,0005635,0005654,0005667,0005737,0005768,0005813,0005829,0005856,0006260,0006281,0006338,0006351,0006468,0006813,0007099,0007165,0007265,0007346,0008284,0010389,0010468,0015030,0016301,0016310,0018105,0019904,0030332,0031453,0031571,0032298,0035173,0043247,0043687,0045740,0045893,0046872,0051298,0051301,0051321,0071732,0090398,0097123,0097124,0097134,0097135,0097472,0106310,1905784 P24941 22893598 301 SPEFMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 4fr4 A 2.29 BS01 STU A 1 I29 A50 K52 L102 L103 G106 D107 D150 L153 T163 R304 L305 I16 A37 K39 L89 L90 G93 D94 D137 L140 T150 R291 L292 D146 K148 D150 N151 D164 T183 D133 K135 D137 N138 D151 T170 2.7.11.1 0004672,0004674,0005524,0005886,0006338,0006468,0016310,0035556,0044024,0046872,0106310 Q8WU08 401 ENEDVNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMALDYLQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITTMAGTKPYMAPEMFSSRKGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFETTVVTYPSAWSQEMVSLLKKLLEPNPDQRFSQLSDVQNFPYMNDINWDAVFQKRLIPGFIPNKGRLNCDPTFELEEMILESKPKEKDMRKCDSSQTCLLQEHLDSVQKEFIIFNREKVNRDFNK 4fr4 B 2.29 BS01 STU B 1 I29 A50 K52 V84 L102 L103 G106 D107 D150 L153 T163 L305 I16 A37 K39 V71 L89 L90 G93 D94 D137 L140 T150 L292 D146 K148 D150 N151 D164 T183 D133 K135 D137 N138 D151 T170 2.7.11.1 0004672,0004674,0005524,0005886,0006338,0006468,0016310,0035556,0044024,0046872,0106310 Q8WU08 401 ENEDVNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMALDYLQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITTMAGTKPYMAPEMFSSRKGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFETTVVTYPSAWSQEMVSLLKKLLEPNPDQRFSQLSDVQNFPYMNDINWDAVFQKRLIPGFIPNKGRLNCDPTFELEEMILESKKKEKDMRKCDSSQTCLLQEHLDSVQKEFIIFNREKVNRDFNK 4fr4 C 2.29 BS01 STU C 1 I29 A50 K52 V84 L102 L103 G106 D107 D150 L153 T163 L305 I16 A37 K39 V71 L89 L90 G93 D94 D137 L140 T150 L292 D146 K148 D150 N151 D164 T183 D133 K135 D137 N138 D151 T170 2.7.11.1 0004672,0004674,0005524,0005886,0006338,0006468,0016310,0035556,0044024,0046872,0106310 Q8WU08 401 ENEDVNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMALDYLQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITTMAGTKPYMAPEMFSSRKGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFETTVVTYPSAWSQEMVSLLKKLLEPNPDQRFSQLSDVQNFPYMNDINWDAVFQKRLIPGFIPNKGRLNCDPTFELEEMILESKRKCDSSQTCLLQEHLDSVQKEFIIFNREKVNRDFNK 4fr4 D 2.29 BS01 STU D 1 I29 A50 K52 L102 L103 G106 D107 D150 L153 T163 I16 A37 K39 L89 L90 G93 D94 D137 L140 T150 D146 K148 D150 N151 D164 T183 D133 K135 D137 N138 D151 T170 2.7.11.1 0004672,0004674,0005524,0005886,0006338,0006468,0016310,0035556,0044024,0046872,0106310 Q8WU08 401 ENEDVNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMALDYLQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITTMAGTKPYMAPEMFSSRKGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFETTVVTYPSAWSQEMVSLLKKLLEPNPDQRFSQLSDVQNFPYMNDINWDAVFQKRLIPGFIPNKGRLNCDPTFELEEMILESKDMRKCDSSQTCLLQEHLDSVQKEFIIFNREKVNRDFNK 4fr4 E 2.29 BS01 STU E 1 I29 A50 K52 D101 L102 L103 D107 D150 L153 T163 I16 A37 K39 D88 L89 L90 D94 D137 L140 T150 D146 K148 D150 N151 D164 T183 D133 K135 D137 N138 D151 T170 2.7.11.1 0004672,0004674,0005524,0005886,0006338,0006468,0016310,0035556,0044024,0046872,0106310 Q8WU08 401 ENEDVNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMALDYLQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITTMAGTKPYMAPEMFSSRKGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFETTVVTYPSAWSQEMVSLLKKLLEPNPDQRFSQLSDVQNFPYMNDINWDAVFQKRLIPGFIPNKGRLNCDPTFELEEMILESKKCDSSQTCLLQEHLDSVQKEFIIFNREKVNRDFN 4fr4 F 2.29 BS01 STU F 1 I29 A50 K52 L102 L103 D107 D150 L153 T163 D164 I16 A37 K39 L89 L90 D94 D137 L140 T150 D151 D146 K148 D150 N151 D164 T183 D133 K135 D137 N138 D151 T170 2.7.11.1 0004672,0004674,0005524,0005886,0006338,0006468,0016310,0035556,0044024,0046872,0106310 Q8WU08 401 ENEDVNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMALDYLQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITTMAGTKPYMAPEMFSSRKGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFETTVVTYPSAWSQEMVSLLKKLLEPNPDQRFSQLSDVQNFPYMNDINWDAVFQKRLIPGFIPNKGRLNCDPTFELEEMILESKDMRKCDSSQTCLLQEHLDSVQKEFIIFNREKVNRDFNK 4mvf A 2.0 BS01 STU A 1 L78 Q80 V86 A99 K101 L148 C149 S150 G151 L199 I212 D213 L19 Q21 V27 A40 K42 L89 C90 S91 G92 L140 I153 D154 D192 K194 E196 N197 D213 D133 K135 E137 N138 D154 2.7.11.1 0004672,0004674,0004683,0005509,0005516,0005524,0005634,0005737,0006338,0006468,0009931,0016310,0018105,0035556,0044024,0046777,0046872,0106310 O15865 601 LILCHSGKLEDKYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKKDRLKNINRFFQEIEIMKKLDHPNIVKLYETYENDNYIYLIMELCSGRELFDSIIENGSFTEKNAATIMKQIFSAIFYLHSLNIVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLKYDKKCDIWSSGVIMYTLLCGYPPFYCFYENDWGSISSDAKNLITKLLTYNPNERCTIEEALNHPWITQMTKSHVELSSTLLKNLKNFKKENELKKIALTIIAKHLCDVEINNLRNIFIALDVDNSGTLSSQEILDGLKKIGYQKIPPDIHQVLRDIDSNASGQIHYTDFLAATIDKQTYLKKEVCLIPFKFFDIDGNGKISVEELKRIFGPLIDKAIDSLLQEVDLNGDGEIDFHEFMLMMSKLEH 4qfg A 3.46 BS01 STU A 1 L22 G23 G25 V30 A43 I77 M93 E94 Y95 V96 G99 E100 E143 N144 L146 D157 L14 G15 G17 V22 A35 I69 M85 E86 Y87 V88 G91 E92 E135 N136 L138 D149 D139 K141 E143 N144 D157 S176 D131 K133 E135 N136 D149 S168 2.7.11.1,2.7.11.26,2.7.11.31 0000785,0002842,0003682,0004672,0004674,0004679,0005515,0005524,0005634,0005737,0005829,0006006,0006325,0006338,0006468,0006633,0006695,0006914,0008284,0008610,0009410,0009411,0009631,0010332,0010508,0010628,0010629,0014823,0016055,0016310,0016324,0016607,0017148,0019395,0030424,0030425,0031000,0031588,0031669,0032007,0032991,0033554,0034599,0042149,0042542,0042557,0042593,0042752,0043025,0043066,0043627,0044024,0044877,0045722,0045821,0045893,0046321,0046326,0046627,0046872,0047322,0048511,0048643,0050321,0050870,0050995,0055089,0060627,0061744,0061762,0062028,0070050,0070301,0070507,0071277,0071333,0071361,0071380,0071456,0071466,0097009,0106310,0140823,1903109,1903829,1903944,1903955,1904179,1904262,1904428,1905691,1990044,2000758 P54645 25066137 601 GRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTFSKMSLQLYQVDSRTYLLDFRSIDDERPGSHTIEFFEMCANLIKILAQ 4qfr A 3.34 BS01 STU A 1 L22 G23 G25 V30 A43 K45 I77 E94 Y95 V96 G99 E100 E143 L146 A156 D157 L14 G15 G17 V22 A35 K37 I69 E86 Y87 V88 G91 E92 E135 L138 A148 D149 D139 K141 E143 N144 D157 S176 D131 K133 E135 N136 D149 S168 2.7.11.1,2.7.11.26,2.7.11.31 0000785,0002842,0003682,0004672,0004674,0004679,0005515,0005524,0005634,0005737,0005829,0006006,0006325,0006338,0006468,0006633,0006695,0006914,0008284,0008610,0009410,0009411,0009631,0010332,0010508,0010628,0010629,0014823,0016055,0016310,0016324,0016607,0017148,0019395,0030424,0030425,0031000,0031588,0031669,0032007,0032991,0033554,0034599,0042149,0042542,0042557,0042593,0042752,0043025,0043066,0043627,0044024,0044877,0045722,0045821,0045893,0046321,0046326,0046627,0046872,0047322,0048511,0048643,0050321,0050870,0050995,0055089,0060627,0061744,0061762,0062028,0070050,0070301,0070507,0071277,0071333,0071361,0071380,0071456,0071466,0097009,0106310,0140823,1903109,1903829,1903944,1903955,1904179,1904262,1904428,1905691,1990044,2000758 P54645 25066137 601 GRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTFSKMSLQLYQVDSRTYLLDFRSIDDSHTIEFFEMCANLIKILAQ 4qfs A 3.55 BS01 STU A 1 L22 G23 G25 V30 A43 I77 E94 Y95 V96 E100 E143 N144 L146 A156 D157 L14 G15 G17 V22 A35 I69 E86 Y87 V88 E92 E135 N136 L138 A148 D149 D139 K141 E143 N144 D157 S176 D131 K133 E135 N136 D149 S168 2.7.11.1,2.7.11.26,2.7.11.31 0000785,0002842,0003682,0004672,0004674,0004679,0005515,0005524,0005634,0005737,0005829,0006006,0006325,0006338,0006468,0006633,0006695,0006914,0008284,0008610,0009410,0009411,0009631,0010332,0010508,0010628,0010629,0014823,0016055,0016310,0016324,0016607,0017148,0019395,0030424,0030425,0031000,0031588,0031669,0032007,0032991,0033554,0034599,0042149,0042542,0042557,0042593,0042752,0043025,0043066,0043627,0044024,0044877,0045722,0045821,0045893,0046321,0046326,0046627,0046872,0047322,0048511,0048643,0050321,0050870,0050995,0055089,0060627,0061744,0061762,0062028,0070050,0070301,0070507,0071277,0071333,0071361,0071380,0071456,0071466,0097009,0106310,0140823,1903109,1903829,1903944,1903955,1904179,1904262,1904428,1905691,1990044,2000758 P54645 25066137 601 GRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTFSKMSLQLYQVDSRTYLLDFRSIDDSHTIEFFEMCANLIKILAQ 4qmy A 1.883 BS01 STU A 1 G31 F35 M99 E100 Y101 L102 L151 D162 G21 F25 M89 E90 Y91 L92 L141 D152 D144 K146 A148 N149 D162 D171 T182 D134 K136 A138 N139 D152 D161 T172 2.7.11.1 0004672,0005524,0006468 ic50=0.004uM -logKd/Ki=8.40, IC50=0.004uM Q9Y6E0 27135311 401 PGMQNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQ 4rer A 4.047 BS01 STU A 1 L24 G25 G27 A45 M95 Y97 V98 G101 E102 E145 N146 L148 L14 G15 G17 A35 M85 Y87 V88 G91 E92 E135 N136 L138 D141 K143 E145 N146 D159 S178 D131 K133 E135 N136 D149 S168 2.7.11.1,2.7.11.26,2.7.11.31 0000785,0001666,0002842,0003682,0004672,0004674,0004679,0004691,0005515,0005524,0005634,0005654,0005737,0005829,0006006,0006325,0006338,0006468,0006633,0006695,0006914,0007165,0008284,0008610,0009410,0009411,0009631,0010332,0010508,0010628,0010629,0014823,0016055,0016310,0016324,0016607,0019395,0030424,0030425,0031000,0031588,0031669,0032007,0032991,0033554,0034599,0042149,0042542,0042593,0042752,0043025,0043066,0043627,0044024,0044877,0045542,0045821,0045893,0046318,0046627,0046872,0047322,0048156,0048511,0048643,0050321,0050870,0050995,0055089,0060627,0061744,0061762,0062028,0070050,0070301,0070507,0071277,0071333,0071361,0071380,0071456,0071466,0097009,0106310,0140823,1903109,1903829,1903944,1903955,1904179,1904262,1904428,1905691,1990044,2000758 Q13131 25412657 601 GSVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRASIKDIREHEWFKQDLPKYLFPEDPSYSDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDDHHLTRPHPERVPFLVAETPRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDGITPRPGSHTIEFFEMCANLIKILAQ 4rew A 4.58 BS01 STU A 1 L24 G25 G27 V32 A45 K47 Y97 V98 E102 N146 L148 D159 L14 G15 G17 V22 A35 K37 Y87 V88 E92 N136 L138 D149 D141 K143 E145 N146 D159 S178 D131 K133 E135 N136 D149 S168 2.7.11.1,2.7.11.26,2.7.11.31 0000785,0001666,0002842,0003682,0004672,0004674,0004679,0004691,0005515,0005524,0005634,0005654,0005737,0005829,0006006,0006325,0006338,0006468,0006633,0006695,0006914,0007165,0008284,0008610,0009410,0009411,0009631,0010332,0010508,0010628,0010629,0014823,0016055,0016310,0016324,0016607,0019395,0030424,0030425,0031000,0031588,0031669,0032007,0032991,0033554,0034599,0042149,0042542,0042593,0042752,0043025,0043066,0043627,0044024,0044877,0045542,0045821,0045893,0046318,0046627,0046872,0047322,0048156,0048511,0048643,0050321,0050870,0050995,0055089,0060627,0061744,0061762,0062028,0070050,0070301,0070507,0071277,0071333,0071361,0071380,0071456,0071466,0097009,0106310,0140823,1903109,1903829,1903944,1903955,1904179,1904262,1904428,1905691,1990044,2000758 Q13131 25412657 601 GSVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRASIKDIREHEWFKQDLPKYLFPEIDNRRIMNEAKDFYLATSPPDHHLTRPHPERVPFLVAETRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDGPRPGSHTIEFFEMCANLIKILAQ 4rlo B 2.527 BS01 STU B 1 L97 G98 V105 A121 E173 Y174 L175 E222 M225 L13 G14 V21 A37 E66 Y67 L68 E115 M118 D218 K220 E222 N223 D236 T256 D111 K113 E115 N116 D129 T138 2.7.11.1 0004672,0004674,0005524,0006468 P23443 25356520 401 KIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESITIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPL 4u97 A 2.65 BS01 STU A 1 M192 G195 V200 A211 Y262 Y264 M265 L318 S328 M27 G30 V35 A46 Y84 Y86 M87 L140 S150 N311 K313 A315 N316 D329 T351 N133 K135 A137 N138 D151 T165 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 Q9NWZ3 25201411 501 HSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAALKQQFDQEIKVMAKCQHENLVELLGFSLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRNIKSANILLDEAFTAKISDFGLATVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMT 4u97 B 2.65 BS01 STU B 1 M192 G193 E194 V200 A211 Y262 V263 Y264 M265 G268 A315 N316 L318 M27 G28 E29 V35 A46 Y86 V87 Y88 M89 G92 A139 N140 L142 N311 K313 A315 N316 D329 T351 N135 K137 A139 N140 D153 T163 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 Q9NWZ3 25201411 501 HSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAALKQQFDQEIKVMAKCQHENLVELLGFSSDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRNIKSANILLDEAFTAKISDFVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMT 4u9a A 2.8 BS01 STU A 1 M192 E194 G195 V200 A211 K213 Y262 Y264 M265 A315 L318 S328 M27 E29 G30 V35 A46 K48 Y84 Y86 M87 A137 L140 S150 N311 K313 A315 N316 D329 T351 N133 K135 A137 N138 D151 T165 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 Q9NWZ3 25201411 501 HSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAALKQQFDQEIKVMAKCQHENLVELLGFSLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRNIKSANILLDEAFTAKISDFGLATVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMT 4u9a B 2.8 BS01 STU B 1 M192 E194 G195 V200 A211 Y262 Y264 M265 G268 A315 N316 L318 M27 E29 G30 V35 A46 Y86 Y88 M89 G92 A139 N140 L142 N311 K313 A315 N316 D329 T351 N135 K137 A139 N140 D153 T163 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 Q9NWZ3 25201411 501 HSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAALKQQFDQEIKVMAKCQHENLVELLGFSSDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRNIKSANILLDEAFTAKISDFVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMT 4yzc A 2.494 BS01 STU A 1 L577 V586 A597 K599 I642 L644 C645 H692 L695 L16 V25 A36 K38 I75 L77 C78 H117 L120 D688 K690 N693 D711 T734 D113 K115 N118 D136 T158 2.7.11.1,3.1.26.- 0004521,0004540,0004672,0004674,0005524,0006397,0006468,0030968 ic50=3nM -logKd/Ki=8.52, IC50=3nM O75460 26438213 1001 SVVIVGKISFCPKDVLGHGAEGTIVYRGMFDNRDVAVKRILPDREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVRHSFSRRSGVPGTEGWIAPEMLSCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILLGACSLDCLHPEKHEDVIARELIEKMIAMDPQKRPSAKHVLKHPFFWSLEKQLQFFQDVSDRIEKESLDGPIVKQLERGGRAVVKMDWRENITVPLQTDLRKFRTYKGGSVRDLLRAMRNKKHHYRELPAEVRETLGSLPDDFVCYFTSRFPHLLAHTYRAMELCSHERLFQPYYFH 4yzc B 2.494 BS01 STU B 1 L577 V586 A597 K599 I626 I642 L644 C645 H692 L695 L16 V25 A36 K38 I59 I75 L77 C78 H117 L120 D688 K690 N693 D711 T734 D113 K115 N118 D136 T157 2.7.11.1,3.1.26.- 0004521,0004540,0004672,0004674,0005524,0006397,0006468,0030968 ic50=3nM O75460 26438213 1001 SVVIVGKISFCPKDVLGHGAEGTIVYRGMFDNRDVAVKRILPDREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLARHSFSRRSGVPGTEGWIAPEMLSCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILLGACSLDCLHPEKHEDVIARELIEKMIAMDPQKRPSAKHVLKHPFFWSLEKQLQFFQDVSDRIEKESLDGPIVKQLERGGRAVVKMDWRENITVPLQTDLRKFRTYKGGSVRDLLRAMRNKKHHYRELPAEVRETLGSLPDDFVCYFTSRFPHLLAHTYRAMELCSHERLFQPYYFH 5e8w A 1.86 BS01 STU A 1 I211 K213 V219 A230 L260 Y282 H283 G286 K337 L340 D351 I13 K15 V21 A32 L62 Y84 H85 G88 K139 L142 D153 D333 K335 N338 D351 T375 D135 K137 N140 D153 T177 2.7.11.30 0004672,0004675,0005524,0006468,0007178,0016020 -logKd/Ki=4.39, IC50=41uM P36897 27139629 601 MTIARDIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGI 5e8x A 1.45 BS01 STU A 1 V211 K213 G214 V219 A230 K232 F282 H283 G286 N287 L340 D351 V12 K14 G15 V20 A31 K33 F83 H84 G87 N88 L141 D152 D333 K335 K337 N338 D351 D366 T375 D134 K136 K138 N139 D152 D167 T176 2.7.11.30 0004672,0004675,0005524,0006468,0007178,0016020 P36897 27139629 601 TIARDIVLQESVGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIFQTVMLRHENILGFIAADNKDNGTWTQLWLVTDFHEHGNLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCICDFGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM 5e8y A 2.05 BS01 STU A 1 V250 G251 V258 A275 K277 F327 H328 G331 N332 S383 L386 C396 D397 V11 G12 V19 A32 K34 F84 H85 G88 N89 S140 L143 C153 D154 D379 K381 N384 D397 D411 T421 D136 K138 N141 D154 D168 T178 2.7.11.30 0004672,0004675,0005524,0006468,0007178,0016020 P37173 27139629 601 ELLPIELDTLVGKGRFAEVYKAKLKQQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLASAMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHPCVASMADNVLADAGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSEL 5ezv A 2.99 BS01 STU A 1 L22 G23 G25 V30 A43 K45 I77 M93 E94 Y95 V96 E100 E143 N144 L146 A156 L15 G16 G18 V23 A36 K38 I70 M86 E87 Y88 V89 E93 E136 N137 L139 A149 D139 K141 E143 N144 D157 S176 D132 K134 E136 N137 D150 S169 2.7.11.1,2.7.11.26,2.7.11.31 0004672,0004679,0005524,0006468 P54646,Q13131 26952388 601 DGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASRPHPERVPFKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDLGSHTMDFFEMCASLITTLA 5ezv C 2.99 BS01 STU C 1 L22 G23 G25 V30 A43 K45 E94 Y95 V96 E100 E143 N144 L146 D157 L14 G15 G17 V22 A35 K37 E86 Y87 V88 E92 E135 N136 L138 D149 D139 K141 E143 N144 D157 S176 D131 K133 E135 N136 D149 S168 2.7.11.1,2.7.11.26,2.7.11.31 0004672,0004679,0005524,0006468 P54646,Q13131 26952388 601 GRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQLAVAYHLIIDNRRIMNQASEFYLASSRPHPERVKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEPRLGSHTMDFFEMCASLITTLA 5iso A 2.63 BS01 STU A 1 G23 G25 V30 A43 K45 E94 Y95 V96 E100 E143 N144 L146 D157 G15 G17 V22 A35 K37 E86 Y87 V88 E92 E135 N136 L138 D149 D139 K141 E143 N144 D157 S176 D131 K133 E135 N136 D149 S168 2.7.11.1,2.7.11.31 0003682,0004672,0004674,0004679,0004712,0005515,0005524,0005634,0005654,0005737,0005794,0005829,0006325,0006338,0006468,0006633,0006695,0006914,0007165,0008610,0010468,0010494,0010508,0010629,0014850,0016055,0016239,0016241,0016310,0016607,0030424,0030425,0031588,0031669,0032007,0034599,0042149,0042593,0042752,0043025,0043066,0044024,0045821,0046872,0047322,0048511,0055089,0062028,0070507,0071277,0071333,0071380,0071466,0097009,0106310,0140823,1903829,1903944,1904262,1904428,1905691,1990044,2000758 P54646 601 GRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPLKPHPERMPPLIADSVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDPRLGSHTMDFFEMCASLITTLA 5iso C 2.63 BS01 STU C 1 G23 V24 G25 V30 A43 E94 Y95 V96 E100 E143 N144 L146 D157 G15 V16 G17 V22 A35 E86 Y87 V88 E92 E135 N136 L138 D149 D139 K141 E143 N144 D157 S176 D131 K133 E135 N136 D149 S168 2.7.11.1,2.7.11.31 0003682,0004672,0004674,0004679,0004712,0005515,0005524,0005634,0005654,0005737,0005794,0005829,0006325,0006338,0006468,0006633,0006695,0006914,0007165,0008610,0010468,0010494,0010508,0010629,0014850,0016055,0016239,0016241,0016310,0016607,0030424,0030425,0031588,0031669,0032007,0034599,0042149,0042593,0042752,0043025,0043066,0044024,0045821,0046872,0047322,0048511,0055089,0062028,0070507,0071277,0071333,0071380,0071466,0097009,0106310,0140823,1903829,1903944,1904262,1904428,1905691,1990044,2000758 P54646 601 GRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCFEQLAVAYHLIIDNRRIMNQASEFYLASSLKPHPERMPPLIAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDRLGSHTMDFFEMCASLITTL 5kq5 A 3.41 BS01 STU A 1 L22 G23 V24 G25 V30 A43 I77 M93 E94 Y95 V96 G99 E100 E143 N144 L146 D157 L13 G14 V15 G16 V21 A34 I68 M84 E85 Y86 V87 G90 E91 E134 N135 L137 D148 D139 K141 E143 N144 D157 S176 D130 K132 E134 N135 D148 S167 2.7.11.1,2.7.11.26,2.7.11.31 0004672,0004679,0005524,0006468 -logKd/Ki=8.05, Kd=9.0nM P54645 27490827 601 RVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTFSKMSLQLYQVDSRTYLLDFRSIDPGSHTIEFFEMCANLIKILAQ 5loh A 3.1 BS01 STU A 1 I41 A60 M110 Y112 L113 G116 D117 D160 L163 T173 D174 S178 I12 A27 M62 Y64 L65 G68 D69 D112 L115 T125 D126 S130 D156 K158 D160 N161 D174 T741 D108 K110 D112 N113 D126 T135 2.7.11.1 0004672,0004674,0005524,0006468 -logKd/Ki=5.04, IC50=9.1uM Q96GX5 27563826 901 PSIEEFSIVKPISGKVYLGQKGGKLYAVKVVKKADMLALSKSPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKFCGTPDYLAPELLLGRAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKRDIPWPEGEEKLSDNAQSAVEILLTIDDTKRAGMKELKRHPLFSDVDWENLQHQTMPFIPQP 5loh B 3.1 BS01 STU B 1 I41 S42 A60 K62 M110 E111 Y112 L113 G116 D117 D160 N161 L163 T173 L177 I12 S13 A31 K33 M68 E69 Y70 L71 G74 D75 D118 N119 L121 T131 L135 D156 K158 D160 N161 D174 T741 D114 K116 D118 N119 D132 T137 2.7.11.1 0004672,0004674,0005524,0006468 Q96GX5 27563826 901 PSIEEFSIVKPISRGAFGKVYLGQKGGKLYAVKVVKKADMINKALSKSPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLGTPDYLAPELLLGRAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKRDIPWPEGEEKLSDNAQSAVEILLTIDDTKRAGMKELKRHPLFSDVDWENLQHQTMPFIPQP 5ng2 A 2.8 BS01 STU A 1 S25 V32 A45 K47 Y97 M98 S102 Q150 L153 S21 V28 A41 K43 Y93 M94 S98 Q146 L149 N146 K148 Q150 N151 D164 T189 N142 K144 Q146 N147 D160 T171 2.7.10.2,2.7.11.1 0004672,0005524,0006468 O43353 28545134 401 AICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHNLKTQNILLDNEFHVKIADFGLSKWRMMGTIIYMPPENYEPSIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFE 5ng2 B 2.8 BS01 STU B 1 S25 V32 A45 K47 Y97 M98 Q150 N151 L153 S21 V28 A41 K43 Y93 M94 Q146 N147 L149 N146 K148 Q150 N151 D164 T189 N142 K144 Q146 N147 D160 T170 2.7.10.2,2.7.11.1 0004672,0005524,0006468 O43353 28545134 401 AICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHNLKTQNILLDNEFHVKIADFGLSKWRMGTIIYMPPENYEPQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFE 5oor A 1.9 BS01 STU A 1 L15 A36 M84 E85 L86 A87 G90 H134 L137 D148 L13 A34 M74 E75 L76 A77 G80 H124 L127 D138 D130 K132 H134 N135 D148 T170 D120 K122 H124 N125 D138 T160 2.7.11.1 0000077,0004672,0004674,0005524,0006468 O14757 29023112 301 VPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMNIKKEICILKMLNHENVIKFYGHRREGNIQYLFMELASGGSLFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPHNLLLDERDNLKIADYSLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGV 5t5t A 3.46 BS01 STU A 1 L22 G23 V24 G25 V30 A43 K45 M93 E94 Y95 V96 G99 E100 E143 N144 L146 D157 L14 G15 V16 G17 V22 A35 K37 M85 E86 Y87 V88 G91 E92 E135 N136 L138 D149 D139 K141 E143 N144 D157 S176 D131 K133 E135 N136 D149 S168 2.7.11.1,2.7.11.26,2.7.11.31 0004672,0004679,0005524,0006468 P54645 28289077 601 GRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTFSKMSLQLYQVDSRTYLLDFRSIDDERPGSHTIEFFEMCANLIKILAQ 5ufu A 3.45 BS01 STU A 1 L22 G23 V24 G25 V30 A43 K45 I77 E94 Y95 V96 G99 E100 E143 N144 L146 D157 L14 G15 V16 G17 V22 A35 K37 I69 E86 Y87 V88 G91 E92 E135 N136 L138 D149 D139 K141 E143 N144 D157 S176 D131 K133 E135 N136 D149 S168 2.7.11.1,2.7.11.26,2.7.11.31 0004672,0004679,0005524,0006468 P54645 28467931 601 GRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTFSKMSLQLYQVDSRTYLLDFRSIDDERPGSHTIEFFEMCANLIKILAQ 5ved A 2.301 BS01 STU A 1 I327 V335 A348 K350 M395 E396 F397 L398 G401 D444 L447 I28 V36 A49 K51 M96 E97 F98 L99 G102 D145 L148 D440 K442 D444 S445 D458 K467 T478 D141 K143 D145 S146 D159 K168 T179 2.7.11.1 0004672,0005524,0006468 O96013 28993291 601 SHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNR 5wnl A 2.5 BS01 STU A 1 V28 G29 A49 K51 M96 E97 Y98 M99 G102 A147 L150 V19 G20 A40 K42 M84 E85 Y86 M87 G90 A135 L138 N143 A147 N148 D161 N131 A135 N136 D149 2.7.11.1 0004672,0005524,0006468 Q9ERK0 29706531 401 ALGLLRTFDAGEFAGWEKVGSGGFGQVYKVRHVHWKTWLAIKCSPVDDRERMELLEEAKKMEMAKFRYILPVYGICQEPVGLVMEYMETGSLEKLLASEPLPWDLRFRIVHETAVGMNFLHCMSPPLLHLNLKPANILLDAHYHVKISDFGLAKCFGTIAYLPPERIREKSRLFDTKHDVYSFAIVIWGVLTQKKPFADEKNILHIMMKVVKGHRPELPPICRPRPRACASLIGLMQRCWHADPQVRPTFQEITSETEDLCE 6b1u A 2.77 BS01 STU A 1 L22 G23 V24 G25 V30 A43 K45 E94 Y95 V96 G99 E100 E143 L146 L15 G16 V17 G18 V23 A36 K38 E87 Y88 V89 G92 E93 E136 L139 D139 K141 N144 D157 S176 D132 K134 N137 D150 S169 2.7.11.1,2.7.11.31 0003682,0004672,0004674,0004679,0004712,0005515,0005524,0005634,0005654,0005737,0005794,0005829,0006325,0006338,0006468,0006633,0006695,0006914,0007165,0008610,0010468,0010494,0010508,0010629,0014850,0016055,0016239,0016241,0016310,0016607,0030424,0030425,0031588,0031669,0032007,0034599,0042149,0042593,0042752,0043025,0043066,0044024,0045821,0046872,0047322,0048511,0055089,0062028,0070507,0071277,0071333,0071380,0071466,0097009,0106310,0140823,1903829,1903944,1904262,1904428,1905691,1990044,2000758 P54646 29657085 601 DGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQGLPSYLFPEDPSYDANVIDDEAVKEVCEKFESEVMNSLYQDQLAVAYHLIIDNRRIMNQASEFYLASSPLKPHPERMPPLIKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDPRLGSHTMDFFEMCASLITTL 6b1u C 2.77 BS01 STU C 1 L22 G23 G25 V30 A43 E94 Y95 V96 E100 E143 L146 D157 L14 G15 G17 V22 A35 E86 Y87 V88 E92 E135 L138 D149 D139 K141 N144 D157 S176 D131 K133 N136 D149 S168 2.7.11.1,2.7.11.31 0003682,0004672,0004674,0004679,0004712,0005515,0005524,0005634,0005654,0005737,0005794,0005829,0006325,0006338,0006468,0006633,0006695,0006914,0007165,0008610,0010468,0010494,0010508,0010629,0014850,0016055,0016239,0016241,0016310,0016607,0030424,0030425,0031588,0031669,0032007,0034599,0042149,0042593,0042752,0043025,0043066,0044024,0045821,0046872,0047322,0048511,0055089,0062028,0070507,0071277,0071333,0071380,0071466,0097009,0106310,0140823,1903829,1903944,1904262,1904428,1905691,1990044,2000758 P54646 29657085 601 GRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQGLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPMHIPPGLKPHPERMPPLIADAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDPRLGSHTMDFFEMCASLITTLAR 6b2e A 3.8 BS01 STU A 1 L22 G23 V24 V30 A43 E94 Y95 V96 G99 E143 N144 L146 D157 L14 G15 V16 V22 A35 E86 Y87 V88 G91 E135 N136 L138 D149 D139 K141 N144 D157 S176 D131 K133 N136 D149 S168 2.7.11.1,2.7.11.31 0003682,0004672,0004674,0004679,0004712,0005515,0005524,0005634,0005654,0005737,0005794,0005829,0006325,0006338,0006468,0006633,0006695,0006914,0007165,0008610,0010468,0010494,0010508,0010629,0014850,0016055,0016239,0016241,0016310,0016607,0030424,0030425,0031588,0031669,0032007,0034599,0042149,0042593,0042752,0043025,0043066,0044024,0045821,0046872,0047322,0048511,0055089,0062028,0070507,0071277,0071333,0071380,0071466,0097009,0106310,0140823,1903829,1903944,1904262,1904428,1905691,1990044,2000758 P54646 29657085 601 GRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQGLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQAYHLIIDNRRIMNQASEFYLASSPLKPHPERMPPLIAKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDLGSHTMDFFEMCASLITTLA 6c9f A 2.924 BS02 STU A 1 A45 M95 E96 Y97 V98 G101 E102 E145 N146 L148 D159 A35 M85 E86 Y87 V88 G91 E92 E135 N136 L138 D149 D141 K143 E145 N146 D159 S178 D131 K133 E135 N136 D149 S168 2.7.11.1,2.7.11.26,2.7.11.31 0004672,0004679,0005524,0006468 Q13131 30478170 602 GSVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDELTPRPGSHTIEFFEMCANLIKILA 6c9g A 2.7 BS02 STU A 1 L24 V26 V32 A45 K47 M95 E96 Y97 V98 G101 E102 E145 N146 L148 D159 L14 V16 V22 A35 K37 M85 E86 Y87 V88 G91 E92 E135 N136 L138 D149 D141 K143 E145 N146 D159 S178 D131 K133 E135 N136 D149 S168 2.7.11.1,2.7.11.26,2.7.11.31 0004672,0004679,0005524,0006468 Q13131 30478170 602 GSVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEIDNRRIMNEAKDFRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDELTPRPGSHTIEFFEMCANLIKILA 6c9h A 2.65 BS02 STU A 1 G25 A45 K47 M95 Y97 V98 G101 E102 E145 N146 L148 D159 G15 A35 K37 M85 Y87 V88 G91 E92 E135 N136 L138 D149 D141 K143 E145 N146 D159 S178 D131 K133 E135 N136 D149 S168 2.7.11.1,2.7.11.26,2.7.11.31 0004672,0004679,0005524,0006468 Q13131 30478170 602 GSVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPTRPHPERVPFKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDELTPRPGSHTIEFFEMCANLIKILA 6c9j A 3.05 BS02 STU A 1 G25 V26 G27 A45 M95 E96 Y97 V98 G101 E102 E145 N146 L148 D159 G15 V16 G17 A35 M85 E86 Y87 V88 G91 E92 E135 N136 L138 D149 D141 K143 E145 N146 D159 S178 D131 K133 E135 N136 D149 S168 2.7.11.1,2.7.11.26,2.7.11.31 0004672,0004679,0005524,0006468 Q13131 30478170 602 GSVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPETRPHPERVPFLVAKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDELTPRPGSHTIEFFEMCANLIKILAQ 6e4t A 3.4 BS02 STU A 1 L22 G23 V24 G25 V30 A43 I77 E94 Y95 V96 G99 E100 E143 N144 L146 D157 L14 G15 V16 G17 V22 A35 I69 E86 Y87 V88 G91 E92 E135 N136 L138 D149 D139 K141 E143 N144 D157 S176 D131 K133 E135 N136 D149 S168 2.7.11.1,2.7.11.26,2.7.11.31 0004672,0004679,0005524,0006468 P54645 30036059 602 GRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTFSKMSLQLYQVDSRTYLLDFRSIDDSHTIEFFEMCANLIKILAQ 6e4u A 3.27 BS01 STU A 1 L22 G23 V24 G25 V30 A43 M93 E94 Y95 V96 G99 E100 E143 N144 L146 D157 L14 G15 V16 G17 V22 A35 M85 E86 Y87 V88 G91 E92 E135 N136 L138 D149 D139 K141 E143 N144 D157 S176 D131 K133 E135 N136 D149 S168 2.7.11.1,2.7.11.26,2.7.11.31 0004672,0004679,0005524,0006468 P54645 30036059 601 GRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTFSKMSLQLYQVDSRTYLLDFRSIDDPGSHTIEFFEMCANLIKILAQ 6e4w A 3.35 BS01 STU A 1 L22 G23 V24 G25 V30 A43 I77 M93 E94 Y95 V96 G99 E100 E143 N144 L146 D157 L14 G15 V16 G17 V22 A35 I69 M85 E86 Y87 V88 G91 E92 E135 N136 L138 D149 D139 K141 E143 N144 D157 S176 D131 K133 E135 N136 D149 S168 2.7.11.1,2.7.11.26,2.7.11.31 0004672,0004679,0005524,0006468 P54645 30036059 601 GRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTFSKMSLQLYQVDSRTYLLDFRSIDDSHTIEFFEMCANLIKILAQ 7ako A 1.8 BS02 STU A 1 L15 V23 A36 E85 Y86 C87 G90 E91 E134 L137 D148 L14 V22 A35 E84 Y85 C86 G89 E90 E133 L136 D147 D130 K132 N135 D148 T170 D129 K131 N134 D147 T169 2.7.11.1 0000077,0004672,0004674,0005524,0006468 O14757 33789090 301 AVPFVEDWRLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKK 7ako B 1.8 BS03 STU B 1 L15 V23 A36 E85 Y86 C87 G90 E91 E134 L137 D148 L15 V23 A36 E85 Y86 C87 G90 E91 E134 L137 D148 D130 K132 N135 D148 T170 D130 K132 N135 D148 T170 2.7.11.1 0000077,0004672,0004674,0005524,0006468 O14757 33789090 301 SAVPFVEDWRLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKK 7nvq A 2.05 BS01 STU A 1 I10 G11 E12 G13 A31 K33 V64 F80 E81 F82 L83 H84 D86 Q131 L134 D145 I10 G11 E12 G13 A31 K33 V57 F73 E74 F75 L76 H77 D79 Q124 L127 D138 D127 K129 Q131 N132 D145 T158 T165 D120 K122 Q124 N125 D138 T151 T158 2.7.11.22 0000082,0000086,0000122,0000287,0000307,0000781,0000793,0000805,0000806,0001673,0004672,0004674,0004693,0005515,0005524,0005634,0005635,0005654,0005667,0005737,0005768,0005813,0005829,0005856,0006260,0006281,0006338,0006351,0006468,0006813,0007099,0007165,0007265,0007346,0008284,0010389,0010468,0015030,0016301,0016310,0018105,0019904,0030332,0031453,0031571,0032298,0035173,0043247,0043687,0045740,0045893,0046872,0051298,0051301,0051321,0071732,0090398,0097123,0097124,0097134,0097135,0097472,0106310,1905784 P24941 34188616 301 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVP 8bik A 2.5 BS01 STU A 1 L22 G23 V24 G25 V30 A43 M93 Y95 V96 E100 E143 L146 D157 L15 G16 V17 G18 V23 A36 M86 Y88 V89 E93 E136 L139 D150 2.7.11.1,2.7.11.31 0003682,0004672,0004674,0004679,0004712,0005515,0005524,0005634,0005654,0005737,0005794,0005829,0006325,0006338,0006468,0006633,0006695,0006914,0007165,0008610,0010468,0010494,0010508,0010629,0014850,0016055,0016239,0016241,0016310,0016607,0030424,0030425,0031588,0031669,0032007,0034599,0042149,0042593,0042752,0043025,0043066,0044024,0045821,0046872,0047322,0048511,0055089,0062028,0070507,0071277,0071333,0071380,0071466,0097009,0106310,0140823,1903829,1903944,1904262,1904428,1905691,1990044,2000758 P54646 1001 DGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPLKPHPERMPPLIADKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDPRLGSHTMDFFEMCASLITTLA 8bik D 2.5 BS01 STU D 1 L22 G23 V24 G25 V30 A43 Y95 V96 E100 E143 L146 D157 L14 G15 V16 G17 V22 A35 Y87 V88 E92 E135 L138 D149 2.7.11.1,2.7.11.31 0003682,0004672,0004674,0004679,0004712,0005515,0005524,0005634,0005654,0005737,0005794,0005829,0006325,0006338,0006468,0006633,0006695,0006914,0007165,0008610,0010468,0010494,0010508,0010629,0014850,0016055,0016239,0016241,0016310,0016607,0030424,0030425,0031588,0031669,0032007,0034599,0042149,0042593,0042752,0043025,0043066,0044024,0045821,0046872,0047322,0048511,0055089,0062028,0070507,0071277,0071333,0071380,0071466,0097009,0106310,0140823,1903829,1903944,1904262,1904428,1905691,1990044,2000758 P54646 1001 GRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYPQDQLAVAYHLIIDNRRIMNQASEFYLASSPLKPHPERMPPLIAKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDLGSHTMDFFEMCASLITTLA 8e4t A 1.95 BS01 STU A 1 V1557 A1573 K1575 H1623 M1624 G1627 R1670 L1673 V26 A42 K44 H92 M93 G96 R139 L142 2.7.10.1 0004672,0004713,0005524,0006468 A9VBW0 37310965 1901 SKEPRELNREWLIVLSELGQGAFGIVYEASLSEPKAPEIQVAAKSLRKDAMDNEREELLEEALVMAQMEHANVVGLIGVITKGRPIYVVLEHMRNGSLKDYVMNKTCTPAQQVTWSRQVASGMAHIHSLGFIHRDLAARNVLLSASLTAKVADFGLARESTDSRGGNVPVRWTAPEALEDNIFSEKSDVWAFGVLMYEVYTKAAMPYTGWNNQRVWIEVTNGFRLPCPADCPLPVFKIMSMCWLHDRHERPSFETLVKALAALETDSD 8e4t A 1.95 BS02 STU A 2 G1701 G1702 V1706 N1748 G165 G166 V170 N212 2.7.10.1 0004672,0004713,0005524,0006468 A9VBW0 37310965 1902 SKEPRELNREWLIVLSELGQGAFGIVYEASLSEPKAPEIQVAAKSLRKDAMDNEREELLEEALVMAQMEHANVVGLIGVITKGRPIYVVLEHMRNGSLKDYVMNKTCTPAQQVTWSRQVASGMAHIHSLGFIHRDLAARNVLLSASLTAKVADFGLARESTDSRGGNVPVRWTAPEALEDNIFSEKSDVWAFGVLMYEVYTKAAMPYTGWNNQRVWIEVTNGFRLPCPADCPLPVFKIMSMCWLHDRHERPSFETLVKALAALETDSD 8jpb G 3.07 BS01 STU G 1 I197 G198 V205 A218 K220 D272 L273 M274 L324 I196 G197 V204 A217 K219 D271 L272 M273 L323 2.7.11.15 0001664,0002026,0002029,0002031,0003108,0004672,0004674,0004703,0005515,0005524,0005737,0005829,0005886,0006468,0006886,0007165,0007186,0007213,0009966,0016020,0016310,0018105,0031694,0031755,0042995,0045202,0045880,0045988,0047696,0060048,0098793,0098794,1901081,1903566 P21146 37532940 701 ADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLACSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEPDMIFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRDLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKTKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQ 8jpc G 3.07 BS02 STU G 1 I197 G198 V205 A218 K220 D272 L273 M274 L324 I196 G197 V204 A217 K219 D271 L272 M273 L323 2.7.11.15 0001664,0002026,0002029,0002031,0003108,0004672,0004674,0004703,0005515,0005524,0005737,0005829,0005886,0006468,0006886,0007165,0007186,0007213,0009966,0016020,0016310,0018105,0031694,0031755,0042995,0045202,0045880,0045988,0047696,0060048,0098793,0098794,1901081,1903566 P21146 37532940 701 ADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLACSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEPDMIFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRDLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKTKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQ 8jpd G 2.81 BS01 STU G 1 I197 G198 V205 A218 K220 D272 L273 M274 L324 I196 G197 V204 A217 K219 D271 L272 M273 L323 2.7.11.15 0001664,0002026,0002029,0002031,0003108,0004672,0004674,0004703,0005515,0005524,0005737,0005829,0005886,0006468,0006886,0007165,0007186,0007213,0009966,0016020,0016310,0018105,0031694,0031755,0042995,0045202,0045880,0045988,0047696,0060048,0098793,0098794,1901081,1903566 P21146 37532940 701 ADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLACSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEPDMIFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRDLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKTKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQ