1bto A 2.0 BS04 SSB A 1 S48 H67 F93 L116 L141 C174 S48 H67 F93 L116 L141 C174 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 1.1.1.1 0004022,0004745,0005737,0005829,0008270,0016491,0042572,0042573,0046872 Ki=0.31uM P00327 9003191 378 STAGKVIKCKAAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVSGTLVTPLPVIAGHEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQDGTSRFTCRGKPIHHFLGTSTFSQYTVVDEISVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATECVNPQDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQNLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGFDLLRSGESIRTILTF 1bto A 2.0 BS05 SSB D 1 M306 L309 M306 L309 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 1.1.1.1 0004022,0004745,0005737,0005829,0008270,0016491,0042572,0042573,0046872 Ki=0.31uM P00327 9003191 378 STAGKVIKCKAAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVSGTLVTPLPVIAGHEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQDGTSRFTCRGKPIHHFLGTSTFSQYTVVDEISVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATECVNPQDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQNLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGFDLLRSGESIRTILTF 1bto B 2.0 BS04 SSB B 1 S48 H67 F93 L116 L141 C174 S48 H67 F93 L116 L141 C174 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 1.1.1.1 0004022,0004745,0005737,0005829,0008270,0016491,0042572,0042573,0046872 Ki=0.31uM P00327 9003191 378 STAGKVIKCKAAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVSGTLVTPLPVIAGHEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQDGTSRFTCRGKPIHHFLGTSTFSQYTVVDEISVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATECVNPQDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQNLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGFDLLRSGESIRTILTF 1bto B 2.0 BS05 SSB C 1 M306 L309 M306 L309 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 1.1.1.1 0004022,0004745,0005737,0005829,0008270,0016491,0042572,0042573,0046872 Ki=0.31uM P00327 9003191 378 STAGKVIKCKAAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVSGTLVTPLPVIAGHEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQDGTSRFTCRGKPIHHFLGTSTFSQYTVVDEISVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATECVNPQDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQNLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGFDLLRSGESIRTILTF 1bto C 2.0 BS01 SSB B 1 M306 L309 M306 L309 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 1.1.1.1 0004022,0004745,0005737,0005829,0008270,0016491,0042572,0042573,0046872 Ki=0.31uM P00327 9003191 378 STAGKVIKCKAAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVSGTLVTPLPVIAGHEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQDGTSRFTCRGKPIHHFLGTSTFSQYTVVDEISVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATECVNPQDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQNLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGFDLLRSGESIRTILTF 1bto C 2.0 BS05 SSB C 1 S48 H67 F93 L141 C174 V294 S48 H67 F93 L141 C174 V294 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 1.1.1.1 0004022,0004745,0005737,0005829,0008270,0016491,0042572,0042573,0046872 Ki=0.31uM P00327 9003191 378 STAGKVIKCKAAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVSGTLVTPLPVIAGHEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQDGTSRFTCRGKPIHHFLGTSTFSQYTVVDEISVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATECVNPQDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQNLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGFDLLRSGESIRTILTF 1bto D 2.0 BS01 SSB A 1 M306 L309 M306 L309 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 1.1.1.1 0004022,0004745,0005737,0005829,0008270,0016491,0042572,0042573,0046872 Ki=0.31uM P00327 9003191 378 STAGKVIKCKAAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVSGTLVTPLPVIAGHEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQDGTSRFTCRGKPIHHFLGTSTFSQYTVVDEISVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATECVNPQDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQNLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGFDLLRSGESIRTILTF 1bto D 2.0 BS05 SSB D 1 S48 H67 F93 L141 C174 V294 S48 H67 F93 L141 C174 V294 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 1.1.1.1 0004022,0004745,0005737,0005829,0008270,0016491,0042572,0042573,0046872 Ki=0.31uM P00327 9003191 378 STAGKVIKCKAAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVSGTLVTPLPVIAGHEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQDGTSRFTCRGKPIHHFLGTSTFSQYTVVDEISVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATECVNPQDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQNLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGFDLLRSGESIRTILTF 3bto A 1.66 BS04 SSB A 1 S48 L57 H67 F93 L141 C174 V294 S48 L57 H67 F93 L141 C174 V294 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 1.1.1.1 0004022,0004745,0005737,0005829,0008270,0016491,0042572,0042573,0046872 Ki=0.72uM P00327 9003191 378 STAGKVIKCKAAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVSGTLVTPLPVIAGHEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQDGTSRFTCRGKPIHHFLGTSTFSQYTVVDEISVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATECVNPQDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQNLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGFDLLRSGESIRTILTF 3bto B 1.66 BS04 SSB B 1 S48 L57 H67 F93 L116 L141 C174 V294 S48 L57 H67 F93 L116 L141 C174 V294 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 1.1.1.1 0004022,0004745,0005737,0005829,0008270,0016491,0042572,0042573,0046872 Ki=0.72uM P00327 9003191 378 STAGKVIKCKAAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVSGTLVTPLPVIAGHEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQDGTSRFTCRGKPIHHFLGTSTFSQYTVVDEISVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATECVNPQDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQNLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGFDLLRSGESIRTILTF 3bto C 1.66 BS04 SSB C 1 S48 H67 F93 L141 C174 V294 S48 H67 F93 L141 C174 V294 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 1.1.1.1 0004022,0004745,0005737,0005829,0008270,0016491,0042572,0042573,0046872 Ki=0.72uM P00327 9003191 378 STAGKVIKCKAAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVSGTLVTPLPVIAGHEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQDGTSRFTCRGKPIHHFLGTSTFSQYTVVDEISVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATECVNPQDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQNLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGFDLLRSGESIRTILTF 3bto D 1.66 BS04 SSB D 1 S48 L57 H67 F93 L116 L141 C174 V294 S48 L57 H67 F93 L116 L141 C174 V294 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 1.1.1.1 0004022,0004745,0005737,0005829,0008270,0016491,0042572,0042573,0046872 Ki=0.72uM P00327 9003191 378 STAGKVIKCKAAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVSGTLVTPLPVIAGHEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQDGTSRFTCRGKPIHHFLGTSTFSQYTVVDEISVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATECVNPQDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQNLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGFDLLRSGESIRTILTF