4zun A 1.4 BS01 SS9 A 1 H159 Y168 D195 F225 Y323 H159 Y168 D195 F225 Y323 3.5.1.-,3.5.1.48,3.5.1.62 0004407,0006338,0016787,0046872,0047609,0047611 ic50=26uM -logKd/Ki=4.59, IC50=26uM IC50=26000nM Q48935 26200446 401 MRVIFSEDHKLRNAKTELYGGELVPPFEAPFRAEWILAAVKEAGFDDVVAPARHGLETVLKVHDAGYLNFLETAWDRWKAAGYKGEAIATSFPVRRTSPRIPTDIEGQIGYYCNAAETAISPGTWEAALSSMASAIDGADLIAAGHKAAFSLCRPPGHHAGIDMFGGYCFINNAAVAAQRLLDKGAKKIAILDVDFHHGNGTQDIFYERGDVFFASLHGDPAEAFPHFLGYAEETGKGAGAGTTANYPMGRGTPYSVWGEALTDSLKRIAAFGAEAIVVSLGVDTFEQDPISFFKLTSPDYITMGRTIAASGVPLLVVMEGGYGVPEIGLNVANVLKGVAG 4zun B 1.4 BS03 SS9 B 1 H159 Y168 D195 F225 Y323 H159 Y168 D195 F225 Y323 3.5.1.-,3.5.1.48,3.5.1.62 0004407,0006338,0016787,0046872,0047609,0047611 ic50=26uM -logKd/Ki=4.59, IC50=26uM IC50=26000nM Q48935 26200446 405 MRVIFSEDHKLRNAKTELYGGELVPPFEAPFRAEWILAAVKEAGFDDVVAPARHGLETVLKVHDAGYLNFLETAWDRWKAAGYKGEAIATSFPVRRTSPRIPTDIEGQIGYYCNAAETAISPGTWEAALSSMASAIDGADLIAAGHKAAFSLCRPPGHHAGIDMFGGYCFINNAAVAAQRLLDKGAKKIAILDVDFHHGNGTQDIFYERGDVFFASLHGDPAEAFPHFLGYAEETGKGAGAGTTANYPMGRGTPYSVWGEALTDSLKRIAAFGAEAIVVSLGVDTFEQDPISFFKLTSPDYITMGRTIAASGVPLLVVMEGGYGVPEIGLNVANVLKGVAG 6phr A 1.65 BS01 SS9 A 1 E17 D19 D117 H159 Y168 H197 F225 Y323 E20 D22 D120 H162 Y171 H200 F228 Y326 ? 0004407,0006338,0046872 ic50=160uM -logKd/Ki=6.70, Kd=0.2uM A0A0J7JFD7 31436969 502 LGSMKTVFSPLHSRRHVKTELDGGLLIEPHEKPSRAETILARVKDQALGEILEPEEFGLGPVKRVHTADYVSFLETCWDEWVAAGKRGEAIPTFWVGRGMRARLPKDIDGRLGYYSLGADTSISDGTWEAARASANVALTAQKLVAEGERAAFALCRPPGHHAHADVFGGYCFFNNAAIAAQAFRDQGYGKVAVLDVDFHHGNGTQAIFYDRSDVLTISLHGDPDLVFPHFLGFEDETGEGDGEAYNLNIVFPPDTPFSIWSQGLEKACERIRTFAPDALVVALGVDTFEEDPISFFKLTSGDYLKLGKRLEQLGLPTVFTMEGGYDVDAIGVNAVNVMQGFEGKS 6phr B 1.65 BS01 SS9 B 1 E17 D19 D117 H159 Y168 D195 H197 F225 E21 D23 D121 H163 Y172 D199 H201 F229 ? 0004407,0006338,0046872 ic50=160uM -logKd/Ki=6.70, Kd=0.2uM A0A0J7JFD7 31436969 502 PLGSMKTVFSPLHSRRHVKTELDGGLLIEPHEKPSRAETILARVKDQALGEILEPEEFGLGPVKRVHTADYVSFLETCWDEWVAAGKRGEAIPTFWVGRGMRARLPKDIDGRLGYYSLGADTSISDGTWEAARASANVALTAQKLVAEGERAAFALCRPPGHHAHADVFGGYCFFNNAAIAAQAFRDQGYGKVAVLDVDFHHGNGTQAIFYDRSDVLTISLHGDPDLVFPHFLGFEDETGEGDGEAYNLNIVFPPDTPFSIWSQGLEKACERIRTFAPDALVVALGVDTFEEDPISFFKLTSGDYLKLGKRLEQLGLPTVFTMEGGYDVDAIGVNAVNVMQGFEGKS 6uii A 2.65 BS01 SS9 A 1 A24 D94 H136 H137 F146 D174 H176 W205 E274 G305 A24 D94 H136 H137 F146 D174 H176 W205 E274 G305 3.5.1.48,3.5.1.62 0005634,0005737,0008270,0016236,0016787,0019213,0033558,0035825,0036269,0040029,0046872,0047609,0047611,0090043,0106047,0106048 -logKd/Ki=6.43, IC50=370nM F1QCV2 31746596 701 AASGSALIFDEEMSRYKLLWTDPACEIEVPERLTVSYEALRTHGLAQRCKAVPVRQATEQEILLAHSEEYLEAVKQTPGMNVEELMAFSKKYNDVYFHQNIYHCAKLAAGATLQLVDSVMKREVRNGMALVRPPGHHSQRSAANGFCVFNNVAFAALYAKKNYNLNRILIVDWDVHHGQGIQYCFEEDPSVLYFSWHRYEHQSFWPNLPESDYSSVGKGKGSGFNINLPWNKVGMTNSDYLAAFFHVLLPVAYEFDPELVIVSAGFDSAIGDPEGEMCALPEIFAHLTHLLMPLAAGKMCVVLEGGFNLTSLGQSVCQTVHSLLGDPTPRISGLGTACDSALESIQNVRNVQSSYWSSFKHLAQSVRTVVVPPPGVELTLPKNCQHSISESTAKEVQRIRDKHFDLTDNILRSLGNIISVLDRMMRSDEVCNGCVVVSDLSVSVQCALQHALTEPAERVLVVYVGDGELPVKTNDGKVFLVQICTKETDKCVNRLTLCLGESLTAGFMQALLGLILPVAYEFNPALVLGIVEETLMRVWGHMTCLIQGLARGRMLTLLQGYDKDLLELTVSALSGASISPLGLRAPKPEDVEMMEKQRQRLQERWGLLRCTVSESW 6uij A 2.9 BS01 SS9 A 1 A24 D94 H137 F146 D174 H176 W205 E274 Y307 A24 D94 H137 F146 D174 H176 W205 E274 Y307 3.5.1.48,3.5.1.62 0005634,0005737,0008270,0016236,0016787,0019213,0033558,0035825,0036269,0040029,0046872,0047609,0047611,0090043,0106047,0106048 F1QCV2 31746596 701 AASGSALIFDEEMSRYKLLWTDPACEIEVPERLTVSYEALRTHGLAQRCKAVPVRQATEQEILLAHSEEYLEAVKQTPGMNVEELMAFSKKYNDVYFHQNIYHCAKLAAGATLQLVDSVMKREVRNGMALVRPPGHHSQRSAANGFCVFNNVAFAALYAKKNYNLNRILIVDWDVHHGQGIQYCFEEDPSVLYFSWHRYEHQSFWPNLPESDYSSVGKGKGSGFNINLPWNKVGMTNSDYLAAFFHVLLPVAYEFDPELVIVSAGFDSAIGDPEGEMCALPEIFAHLTHLLMPLAAGKMCVVLEGGYNLTSLGQSVCQTVHSLLGDPTPRISGLGTACDSALESIQNVRNVQSSYWSSFKHLAQSVRTVVVPPPGVELTLPKNCQHSISESTAKEVQRIRDKHFHDLTDQNILRSLGNIISVLDRMMRSDEVCNGCVVVSDLSVSVQCALQHALTEPAERVLVVYVGDGELPVKTNDGKVFLVQICTTEDKCVNRLTLCLRGESLTAGFMQALLGLILPVAYEFNPALVLGIVEETRLMRVWGHMTCLIQGLARGRMLTLLQGYDKDLLELTVSALSGASISPLGPLRAPKPEDVEMMEKQRQRLQERWGLLRCTVSESW