2qeh A 2.102 BS01 SRO A 1 E7 I21 R22 Y24 H35 I36 Y94 F110 D111 E114 M135 E8 I22 R23 Y25 H36 I37 Y95 F111 D112 E115 M136 ? 0005549,0005576,0007608,0042311 Kd=2.4nM Q7PNF2 17928288 145 METVQDCENKLPPSLKSRLCEIRRYEIIEGPEMDKHIHCVMRALDFVYEDGRGDYHKLYDPLNIIELDKRHDVNLEKCIGECVQVPTSERAHVFYKCLLKSTTGRTFKKVFDLMELKKAGKVPQHQRYTAEFVQIMKDYDKALNC 2ymd A 1.96 BS01 SRO A 1 Y91 W145 V146 C188 C189 Y193 Y91 W145 V146 C188 C189 Y193 ? 0004888,0005216,0005230,0005231,0005515,0006811,0007165,0007268,0016020,0034220,0042391,0042802,0043005,0045202,0046872,0050877,0060078,0060079,0098794,1904315 Kd=693uM -logKd/Ki=3.16, Kd=693uM Q8WSF8 23196367 1213 QANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKVDSSTNEVDLVYWEQQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYESTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGVTCALTFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRERRAGNGFF 2ymd A 1.96 BS02 SRO E 1 I104 V106 M114 I116 I104 V106 M114 I116 ? 0004888,0005216,0005230,0005231,0005515,0006811,0007165,0007268,0016020,0034220,0042391,0042802,0043005,0045202,0046872,0050877,0060078,0060079,0098794,1904315 Kd=693uM -logKd/Ki=3.16, Kd=693uM Q8WSF8 23196367 1213 QANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKVDSSTNEVDLVYWEQQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYESTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGVTCALTFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRERRAGNGFF 2ymd B 1.96 BS01 SRO A 1 I104 V106 M114 I116 I104 V106 M114 I116 ? 0004888,0005216,0005230,0005231,0005515,0006811,0007165,0007268,0016020,0034220,0042391,0042802,0043005,0045202,0046872,0050877,0060078,0060079,0098794,1904315 Kd=693uM -logKd/Ki=3.16, Kd=693uM Q8WSF8 23196367 1213 QANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKVDSSTNEVDLVYWEQQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYESTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGVTCALTFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRERRAGNG 2ymd B 1.96 BS02 SRO B 1 Y91 W145 V146 C188 C189 Y193 Y91 W145 V146 C188 C189 Y193 ? 0004888,0005216,0005230,0005231,0005515,0006811,0007165,0007268,0016020,0034220,0042391,0042802,0043005,0045202,0046872,0050877,0060078,0060079,0098794,1904315 Kd=693uM -logKd/Ki=3.16, Kd=693uM Q8WSF8 23196367 1212 QANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKVDSSTNEVDLVYWEQQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYESTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGVTCALTFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRERRAGNG 2ymd C 1.96 BS01 SRO B 1 I104 V106 M114 I116 I104 V106 M114 I116 ? 0004888,0005216,0005230,0005231,0005515,0006811,0007165,0007268,0016020,0034220,0042391,0042802,0043005,0045202,0046872,0050877,0060078,0060079,0098794,1904315 Kd=693uM Q8WSF8 23196367 1212 QANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKVDSSTNEVDLVYWEQQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYESTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGVTCALTFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRERRAGNGFF 2ymd C 1.96 BS02 SRO C 1 Y91 W145 V146 C188 C189 Y193 Y91 W145 V146 C188 C189 Y193 ? 0004888,0005216,0005230,0005231,0005515,0006811,0007165,0007268,0016020,0034220,0042391,0042802,0043005,0045202,0046872,0050877,0060078,0060079,0098794,1904315 Kd=693uM Q8WSF8 23196367 1213 QANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKVDSSTNEVDLVYWEQQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYESTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGVTCALTFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRERRAGNGFF 2ymd D 1.96 BS01 SRO C 1 I104 V106 I116 I104 V106 I116 ? 0004888,0005216,0005230,0005231,0005515,0006811,0007165,0007268,0016020,0034220,0042391,0042802,0043005,0045202,0046872,0050877,0060078,0060079,0098794,1904315 Kd=693uM Q8WSF8 23196367 1213 QANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKVDSSTNEVDLVYWEQQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYESTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGVTCALTFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRERRAGNGFF 2ymd D 1.96 BS02 SRO D 1 Y91 W145 V146 C188 C189 Y193 Y91 W145 V146 C188 C189 Y193 ? 0004888,0005216,0005230,0005231,0005515,0006811,0007165,0007268,0016020,0034220,0042391,0042802,0043005,0045202,0046872,0050877,0060078,0060079,0098794,1904315 Kd=693uM Q8WSF8 23196367 1214 QANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKVDSSTNEVDLVYWEQQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYESTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGVTCALTFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRERRAGNGFF 2ymd E 1.96 BS01 SRO D 1 I104 V106 M114 I116 I104 V106 M114 I116 ? 0004888,0005216,0005230,0005231,0005515,0006811,0007165,0007268,0016020,0034220,0042391,0042802,0043005,0045202,0046872,0050877,0060078,0060079,0098794,1904315 Kd=693uM Q8WSF8 23196367 1214 QANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKVDSSTNEVDLVYWEQQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYESTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGVTCALTFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRERRAGNGFF 2ymd E 1.96 BS02 SRO E 1 Y91 W145 V146 C188 C189 Y193 Y91 W145 V146 C188 C189 Y193 ? 0004888,0005216,0005230,0005231,0005515,0006811,0007165,0007268,0016020,0034220,0042391,0042802,0043005,0045202,0046872,0050877,0060078,0060079,0098794,1904315 Kd=693uM Q8WSF8 23196367 1213 QANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKVDSSTNEVDLVYWEQQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYESTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGVTCALTFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRERRAGNGFF 2ymd F 1.96 BS01 SRO F 1 Y91 W145 V146 C188 C189 Y193 Y91 W145 V146 C188 C189 Y193 ? 0004888,0005216,0005230,0005231,0005515,0006811,0007165,0007268,0016020,0034220,0042391,0042802,0043005,0045202,0046872,0050877,0060078,0060079,0098794,1904315 Kd=693uM Q8WSF8 23196367 1214 QANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKVDSSTNEVDLVYWEQQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYESTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGVTCALTFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRERRAGNGFF 2ymd F 1.96 BS02 SRO J 1 I104 V106 M114 I116 I104 V106 M114 I116 ? 0004888,0005216,0005230,0005231,0005515,0006811,0007165,0007268,0016020,0034220,0042391,0042802,0043005,0045202,0046872,0050877,0060078,0060079,0098794,1904315 Kd=693uM Q8WSF8 23196367 1213 QANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKVDSSTNEVDLVYWEQQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYESTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGVTCALTFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRERRAGNGFF 2ymd G 1.96 BS01 SRO F 1 I104 V106 M114 I116 I104 V106 M114 I116 ? 0004888,0005216,0005230,0005231,0005515,0006811,0007165,0007268,0016020,0034220,0042391,0042802,0043005,0045202,0046872,0050877,0060078,0060079,0098794,1904315 Kd=693uM Q8WSF8 23196367 1214 QANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKVDSSTNEVDLVYWEQQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYESTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGVTCALTFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRERRAGNGFF 2ymd G 1.96 BS02 SRO G 1 Y91 W145 V146 C188 C189 Y193 Y91 W145 V146 C188 C189 Y193 ? 0004888,0005216,0005230,0005231,0005515,0006811,0007165,0007268,0016020,0034220,0042391,0042802,0043005,0045202,0046872,0050877,0060078,0060079,0098794,1904315 Kd=693uM Q8WSF8 23196367 1213 QANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKVDSSTNEVDLVYWEQQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYESTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGVTCALTFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRERRAGNGFF 2ymd H 1.96 BS01 SRO G 1 I104 M114 I116 I104 M114 I116 ? 0004888,0005216,0005230,0005231,0005515,0006811,0007165,0007268,0016020,0034220,0042391,0042802,0043005,0045202,0046872,0050877,0060078,0060079,0098794,1904315 Kd=693uM Q8WSF8 23196367 1213 QANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKVDSSTNEVDLVYWEQQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYESTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGVTCALTFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRER 2ymd H 1.96 BS02 SRO H 1 Y91 W145 V146 C188 C189 Y193 Y91 W145 V146 C188 C189 Y193 ? 0004888,0005216,0005230,0005231,0005515,0006811,0007165,0007268,0016020,0034220,0042391,0042802,0043005,0045202,0046872,0050877,0060078,0060079,0098794,1904315 Kd=693uM Q8WSF8 23196367 1206 QANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKVDSSTNEVDLVYWEQQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYESTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGVTCALTFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRER 2ymd I 1.96 BS01 SRO H 1 I104 M114 I116 I104 M114 I116 ? 0004888,0005216,0005230,0005231,0005515,0006811,0007165,0007268,0016020,0034220,0042391,0042802,0043005,0045202,0046872,0050877,0060078,0060079,0098794,1904315 Kd=693uM Q8WSF8 23196367 1206 QANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKVDSSTNEVDLVYWEQQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYESTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGVTCALTFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRERRAGNGFF 2ymd I 1.96 BS02 SRO I 1 Y91 W145 V146 C189 Y193 Y91 W145 V146 C189 Y193 ? 0004888,0005216,0005230,0005231,0005515,0006811,0007165,0007268,0016020,0034220,0042391,0042802,0043005,0045202,0046872,0050877,0060078,0060079,0098794,1904315 Kd=693uM Q8WSF8 23196367 1213 QANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKVDSSTNEVDLVYWEQQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYESTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGVTCALTFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRERRAGNGFF 2ymd J 1.96 BS01 SRO I 1 I104 M114 I116 I104 M114 I116 ? 0004888,0005216,0005230,0005231,0005515,0006811,0007165,0007268,0016020,0034220,0042391,0042802,0043005,0045202,0046872,0050877,0060078,0060079,0098794,1904315 Kd=693uM Q8WSF8 23196367 1213 QANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKVDSSTNEVDLVYWEQQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYESTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGVTCALTFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRERRAGNGFF 2ymd J 1.96 BS02 SRO J 1 Y91 W145 V146 C188 C189 Y193 Y91 W145 V146 C188 C189 Y193 ? 0004888,0005216,0005230,0005231,0005515,0006811,0007165,0007268,0016020,0034220,0042391,0042802,0043005,0045202,0046872,0050877,0060078,0060079,0098794,1904315 Kd=693uM Q8WSF8 23196367 1213 QANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKVDSSTNEVDLVYWEQQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYESTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGVTCALTFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRERRAGNGFF 3adv A 2.27 BS01 SRO A 1 C285 S289 Y327 L330 M364 H449 C71 S75 Y113 L116 M150 H235 ? 0003677,0004879,0005634,0006355 Kd=933uM -logKd/Ki=3.03, Kd=933uM P37231 20717101 1 QLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDL 3adv A 2.27 BS02 SRO A 2 L228 R288 E295 M329 L333 E343 L26 R74 E81 M115 L119 E129 ? 0003677,0004879,0005634,0006355 Kd=933uM -logKd/Ki=3.03, Kd=933uM P37231 20717101 3 QLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDL 3adv B 2.27 BS01 SRO B 1 C285 L340 C73 L128 ? 0003677,0004879,0005634,0006355 Kd=933uM P37231 20717101 4 ESADLRALAKHLYDSYIKSFPLTKAKARAILTGDKSPFVIYDMNSLMMGEDKIKFKHITPLQKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETHPLLQEIY 3brn A 2.0 BS01 SRO A 1 S18 Y27 V43 I82 V84 D106 M108 W118 S14 Y23 V39 I78 V80 D102 M104 W114 ? 0030682,0043176 Kd<2nM -logKd/Ki=8.70, Kd=2nM Q09JR9 18445596 158 AQCDFGGPFQAYKSVNGPGNGGYYLRKTTKPGTPECAYVLVPQNTLSEGQSTSFTYGKLQNGQMIQLTATVTVNGDKIEVTGAGQDLSGTTTVLFSDYRSCDVMRGPDGNYELWVHSSAINLQSYGCCDTKFAQVAGGRPIHHTWQTYCPPLP 3brn B 2.0 BS01 SRO B 1 S18 Y27 F58 V84 M108 W118 S13 Y22 F52 V78 M99 W109 ? 0030682,0043176 Kd<2nM Q09JR9 18445596 158 QCDFGGPFQAYKSVNGPGNGGYYLRKTTKGTPECAYVLVPQNTLSEGQSTSFTYGKLQNGQMIQLTATVTVNGDKIEVTGALSGTTTVLFSDYRSCDVMRGPDGNYELWVHSSAINLQSYGCCDTKFAQVAGGRPIHHTWQTYCPPLP 3nk1 X 2.2 BS01 SRO X 1 A58 Y59 M167 F326 W371 G406 A58 Y59 M167 F326 W371 G406 1.5.3.5 0000166,0005737,0009820,0016491,0018531,0019608 Q93NH4 20006620 433 MYDAIVVGGGFSGLKAARDLTNAGKKVLLLEGGERLGGRAYSRESRNVPGLRVEIGGAYLHRKHHPRLAAELDRYGIPTAAASEFTSFRHRLGPTAVDQAFPIPGSEAVAVEAATYTLLRDAHRIDLEKGLENQDLEDLDIPLNEYVDKLDLPPVSRQFLLAWAWNMLGQPADQASALWMLQLVAAHHYSILGVVLSLDEVFSNGSADLVDAMSQEIPEIRLQTVVTGIDQSGDVVNVTVKDGHAFQAHSVIVATPMNTWRRIVFTPALPERRRSVIEEGHGGQGLKILIHVRGAEAGIECVGDGIFPTLYDYCEVSESERLLVAFTDSGSFDPTDIGAVKDAVLYYLPEVEVLGIDYHDWIADPLFEGPWVAPRVGQFSRVHKELGEPAGRIHFVGSDVSLEFPGYIEGALETAECAVNAILHS 3q6k A 2.52 BS01 SRO A 1 T29 Q91 F223 T327 N342 F344 T29 Q91 F223 T327 N342 F344 ? 0005576 Kd=4.3nM (21795673) -logKd/Ki=8.37, Kd=4.3nM Q5WPU9 21795673 383 ADTQGYKWKQLLYNNVTPGSYNPDNMISTAFAYDAEGEKLFLAVPRKLPRVPYTLAEVDTKNSLGVKGKHSPLLNKFSGHKTGKELTSIYQPVIDDCRRLWVVDIGSVEYRSRGAKDYPSHRPAIVAYDLKQPNYPEVVRYYFPTRLVEKPTYFGGFAVDVANPKGDCSETFVYITNFLRGALFIYDHKKQDSWNVTHPTFKAERPTKFDYGGKEYEFKAGIFGITLGDRDSEGNRPAYYLAGSAIKVYSVNTKELKQKGGKLNPELLGNRGKYNDAIALAYDPKTKVIFFAEANTKQVSCWNTQKMPLRMKNTDVVYTSSRFVFGTDISVDSKGGLWFMSNGFPPIRKSEKFKYDFPRYRLMRIMDTQEAIAGTACDMN 3q6k B 2.52 BS01 SRO B 1 T29 Y90 T327 N342 F344 T29 Y90 T327 N342 F344 ? 0005576 Kd=4.3nM (21795673) Q5WPU9 21795673 383 ADTQGYKWKQLLYNNVTPGSYNPDNMISTAFAYDAEGEKLFLAVPRKLPRVPYTLAEVDTKNSLGVKGKHSPLLNKFSGHKTGKELTSIYQPVIDDCRRLWVVDIGSVEYRSRGAKDYPSHRPAIVAYDLKQPNYPEVVRYYFPTRLVEKPTYFGGFAVDVANPKGDCSETFVYITNFLRGALFIYDHKKQDSWNVTHPTFKAERPTKFDYGGKEYEFKAGIFGITLGDRDSEGNRPAYYLAGSAIKVYSVNTKELKQKGGKLNPELLGNRGKYNDAIALAYDPKTKVIFFAEANTKQVSCWNTQKMPLRMKNTDVVYTSSRFVFGTDISVDSKGGLWFMSNGFPPIRKSEKFKYDFPRYRLMRIMDTQEAIAGTACDMNA 4dtw A 1.8 BS02 SRO A 1 F87 A264 A328 A330 L437 T438 F85 A262 A326 A328 L435 T436 A268 F393 C400 A266 F391 C398 1.14.14.1,1.6.2.4 0004497,0005506,0016705,0020037 Kd=80uM P14779 22659321 501 KEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQAPKFVRDFAGDGLFTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLRRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLAAGHEATSGLLSFALYFLVKNPHELQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPL 4dtw B 1.8 BS02 SRO B 1 F87 A264 A328 A330 L437 T438 F85 A262 A326 A328 L435 T436 A268 F393 C400 A266 F391 C398 1.14.14.1,1.6.2.4 0004497,0005506,0016705,0020037 Kd=80uM P14779 22659321 502 KEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQAPKFVRDFAGDGLFTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLRRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLAAGHEATSGLLSFALYFLVKNPHELQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPL 4due A 1.7 BS02 SRO A 1 L75 A264 Q437 L74 A261 Q434 S268 F393 C400 S265 F390 C397 1.14.14.1,1.6.2.4 0004497,0005506,0016705,0020037 Kd=0.7uM P14779 22659321 501 IKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTCYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLLTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRADDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHESTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETQLLKPEGFVVKAKSKKIPLG 4due B 1.7 BS02 SRO B 1 L75 L87 A264 Q437 L74 L86 A258 Q431 S268 F393 C400 S262 F387 C394 1.14.14.1,1.6.2.4 0004497,0005506,0016705,0020037 Kd=0.7uM P14779 22659321 501 IKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTCYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLLTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHESTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETQLLKPEGFVVKAKSKKIPLG 4duf A 1.8 BS02 SRO A 1 A264 L437 L438 A263 L436 L437 S268 F393 C400 S267 F392 C399 1.14.14.1,1.6.2.4 0004497,0005506,0016705,0020037 Kd=3.3uM P14779 22659321 501 IKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTCYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLLTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHESTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLLLKPEGFVVKAKSKKIPLGG 4duf B 1.8 BS02 SRO B 1 I263 A264 I262 A263 S268 F393 C400 S267 F392 C399 1.14.14.1,1.6.2.4 0004497,0005506,0016705,0020037 Kd=3.3uM P14779 22659321 501 IKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTCYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLLTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHESTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLLLKPEGFVVKAKSKKIPLGG 4duf C 1.8 BS02 SRO C 1 A264 S268 L438 A263 S267 L437 S268 F393 C400 S267 F392 C399 1.14.14.1,1.6.2.4 0004497,0005506,0016705,0020037 Kd=3.3uM P14779 22659321 501 IKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTCYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLLTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHESTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLLLKPEGFVVKAKSKKIPLGG 4duf D 1.8 BS02 SRO D 1 A264 S268 A263 S267 S268 F393 C400 S267 F392 C399 1.14.14.1,1.6.2.4 0004497,0005506,0016705,0020037 Kd=3.3uM P14779 22659321 501 IKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTCYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLLTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHESTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLLLKPEGFVVKAKSKKIPLGG 6dg7 A 3.32 BS01 SRO A 1 W156 Y207 W149 Y200 ? 0004888,0005216,0005230,0005886,0006811,0007210,0015276,0016020,0022850,0032154,0034220,0042802,0045202,0045211,0051378,0098662,0099505,0099507,0140227,1904602 Ki=361nM, EC50=3400nM P23979 30401837 508 TQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILAVRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHYS 6dg7 A 3.32 BS02 SRO B 1 W63 Y64 W56 Y57 ? 0004888,0005216,0005230,0005886,0006811,0007210,0015276,0016020,0022850,0032154,0034220,0042802,0045202,0045211,0051378,0098662,0099505,0099507,0140227,1904602 Ki=361nM, EC50=3400nM P23979 30401837 508 TQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILAVRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHYS 6dg7 B 3.32 BS01 SRO B 1 W156 F199 Y207 W149 F192 Y200 ? 0004888,0005216,0005230,0005886,0006811,0007210,0015276,0016020,0022850,0032154,0034220,0042802,0045202,0045211,0051378,0098662,0099505,0099507,0140227,1904602 Ki=361nM, EC50=3400nM P23979 30401837 508 TQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILAVRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHYS 6dg7 B 3.32 BS02 SRO C 2 W63 Y64 W56 Y57 ? 0004888,0005216,0005230,0005886,0006811,0007210,0015276,0016020,0022850,0032154,0034220,0042802,0045202,0045211,0051378,0098662,0099505,0099507,0140227,1904602 Ki=361nM, EC50=3400nM P23979 30401837 509 TQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILAVRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHYS 6dg7 C 3.32 BS01 SRO C 1 W63 Y64 W56 Y57 ? 0004888,0005216,0005230,0005886,0006811,0007210,0015276,0016020,0022850,0032154,0034220,0042802,0045202,0045211,0051378,0098662,0099505,0099507,0140227,1904602 Ki=361nM, EC50=3400nM P23979 30401837 508 TQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILAVRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHYS 6dg7 C 3.32 BS02 SRO C 2 W156 F199 Y207 W149 F192 Y200 ? 0004888,0005216,0005230,0005886,0006811,0007210,0015276,0016020,0022850,0032154,0034220,0042802,0045202,0045211,0051378,0098662,0099505,0099507,0140227,1904602 Ki=361nM, EC50=3400nM P23979 30401837 509 TQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILAVRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHYS 6dg7 D 3.32 BS01 SRO C 1 W156 F199 Y207 W149 F192 Y200 ? 0004888,0005216,0005230,0005886,0006811,0007210,0015276,0016020,0022850,0032154,0034220,0042802,0045202,0045211,0051378,0098662,0099505,0099507,0140227,1904602 Ki=361nM, EC50=3400nM P23979 30401837 508 TQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILAVRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHYS 6dg7 D 3.32 BS02 SRO E 1 W63 Y64 W56 Y57 ? 0004888,0005216,0005230,0005886,0006811,0007210,0015276,0016020,0022850,0032154,0034220,0042802,0045202,0045211,0051378,0098662,0099505,0099507,0140227,1904602 Ki=361nM, EC50=3400nM P23979 30401837 508 TQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILAVRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHYS 6dg7 E 3.32 BS01 SRO E 1 W156 F199 Y207 W149 F192 Y200 ? 0004888,0005216,0005230,0005886,0006811,0007210,0015276,0016020,0022850,0032154,0034220,0042802,0045202,0045211,0051378,0098662,0099505,0099507,0140227,1904602 Ki=361nM, EC50=3400nM P23979 30401837 508 TQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILAVRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHYS 6dg8 A 3.89 BS01 SRO A 1 W156 F199 Y207 W149 F192 Y200 ? 0004888,0005216,0005230,0005886,0006811,0007210,0015276,0016020,0022850,0032154,0034220,0042802,0045202,0045211,0051378,0098662,0099505,0099507,0140227,1904602 Ki=361nM, EC50=3400nM P23979 30401837 501 TQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILAVRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHYS 6dg8 A 3.89 BS02 SRO B 2 W63 Y64 Y126 W56 Y57 Y119 ? 0004888,0005216,0005230,0005886,0006811,0007210,0015276,0016020,0022850,0032154,0034220,0042802,0045202,0045211,0051378,0098662,0099505,0099507,0140227,1904602 Ki=361nM, EC50=3400nM P23979 30401837 502 TQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILAVRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHYS 6dg8 B 3.89 BS01 SRO B 1 W63 Y64 R65 Y126 W56 Y57 R58 Y119 ? 0004888,0005216,0005230,0005886,0006811,0007210,0015276,0016020,0022850,0032154,0034220,0042802,0045202,0045211,0051378,0098662,0099505,0099507,0140227,1904602 Ki=361nM, EC50=3400nM P23979 30401837 501 TQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILAVRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHYS 6dg8 B 3.89 BS02 SRO B 2 W156 F199 Y207 W149 F192 Y200 ? 0004888,0005216,0005230,0005886,0006811,0007210,0015276,0016020,0022850,0032154,0034220,0042802,0045202,0045211,0051378,0098662,0099505,0099507,0140227,1904602 Ki=361nM, EC50=3400nM P23979 30401837 502 TQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILAVRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHYS 6dg8 C 3.89 BS01 SRO B 1 T154 W156 F199 Y207 T147 W149 F192 Y200 ? 0004888,0005216,0005230,0005886,0006811,0007210,0015276,0016020,0022850,0032154,0034220,0042802,0045202,0045211,0051378,0098662,0099505,0099507,0140227,1904602 Ki=361nM, EC50=3400nM P23979 30401837 501 TQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILAVRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHYS 6dg8 C 3.89 BS02 SRO D 1 W63 Y64 R65 Y126 W56 Y57 R58 Y119 ? 0004888,0005216,0005230,0005886,0006811,0007210,0015276,0016020,0022850,0032154,0034220,0042802,0045202,0045211,0051378,0098662,0099505,0099507,0140227,1904602 Ki=361nM, EC50=3400nM P23979 30401837 501 TQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILAVRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHYS 6dg8 D 3.89 BS01 SRO D 1 T154 W156 F199 I201 Y207 T147 W149 F192 I194 Y200 ? 0004888,0005216,0005230,0005886,0006811,0007210,0015276,0016020,0022850,0032154,0034220,0042802,0045202,0045211,0051378,0098662,0099505,0099507,0140227,1904602 Ki=361nM, EC50=3400nM P23979 30401837 501 TQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILAVRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHYS 6dg8 D 3.89 BS02 SRO E 1 W63 Y64 Y126 W56 Y57 Y119 ? 0004888,0005216,0005230,0005886,0006811,0007210,0015276,0016020,0022850,0032154,0034220,0042802,0045202,0045211,0051378,0098662,0099505,0099507,0140227,1904602 Ki=361nM, EC50=3400nM P23979 30401837 501 TQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILAVRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHYS 6dg8 E 3.89 BS01 SRO A 1 W63 Y64 Y126 W56 Y57 Y119 ? 0004888,0005216,0005230,0005886,0006811,0007210,0015276,0016020,0022850,0032154,0034220,0042802,0045202,0045211,0051378,0098662,0099505,0099507,0140227,1904602 Ki=361nM, EC50=3400nM P23979 30401837 501 TQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILAVRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHYS 6dg8 E 3.89 BS02 SRO E 1 W156 F199 Y207 W149 F192 Y200 ? 0004888,0005216,0005230,0005886,0006811,0007210,0015276,0016020,0022850,0032154,0034220,0042802,0045202,0045211,0051378,0098662,0099505,0099507,0140227,1904602 Ki=361nM, EC50=3400nM P23979 30401837 501 TQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILAVRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHYS 6hin A 4.1 BS01 SRO A 1 W63 Y64 R65 Y126 W54 Y55 R56 Y117 ? 0004888,0005216,0005230,0006811,0015276,0016020,0034220,0045211 Ki=361nM, EC50=3400nM P23979 30401839 502 PALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIW 6hin A 4.1 BS02 SRO E 1 W156 Y207 W147 Y198 ? 0004888,0005216,0005230,0006811,0015276,0016020,0034220,0045211 Ki=361nM, EC50=3400nM P23979 30401839 901 PALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIW 6hin B 4.1 BS01 SRO A 1 W156 Y207 W147 Y198 ? 0004888,0005216,0005230,0006811,0015276,0016020,0034220,0045211 Ki=361nM, EC50=3400nM P23979 30401839 502 PALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIW 6hin B 4.1 BS02 SRO B 1 W63 Y64 R65 Y126 W54 Y55 R56 Y117 ? 0004888,0005216,0005230,0006811,0015276,0016020,0034220,0045211 Ki=361nM, EC50=3400nM P23979 30401839 502 PALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIW 6hin C 4.1 BS01 SRO B 1 W156 Y207 W147 Y198 ? 0004888,0005216,0005230,0006811,0015276,0016020,0034220,0045211 Ki=361nM, EC50=3400nM P23979 30401839 502 PALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIW 6hin C 4.1 BS02 SRO C 1 W63 Y64 R65 Y126 W54 Y55 R56 Y117 ? 0004888,0005216,0005230,0006811,0015276,0016020,0034220,0045211 Ki=361nM, EC50=3400nM P23979 30401839 502 PALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIW 6hin D 4.1 BS01 SRO C 1 W156 Y207 W147 Y198 ? 0004888,0005216,0005230,0006811,0015276,0016020,0034220,0045211 Ki=361nM, EC50=3400nM P23979 30401839 502 PALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIW 6hin D 4.1 BS02 SRO D 1 W63 Y64 R65 Y126 W54 Y55 R56 Y117 ? 0004888,0005216,0005230,0006811,0015276,0016020,0034220,0045211 Ki=361nM, EC50=3400nM P23979 30401839 502 PALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIW 6hin E 4.1 BS01 SRO D 1 W156 Y207 W147 Y198 ? 0004888,0005216,0005230,0006811,0015276,0016020,0034220,0045211 Ki=361nM, EC50=3400nM P23979 30401839 502 PALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIW 6hin E 4.1 BS02 SRO E 1 W63 Y64 R65 Y126 W54 Y55 R56 Y117 ? 0004888,0005216,0005230,0006811,0015276,0016020,0034220,0045211 Ki=361nM, EC50=3400nM P23979 30401839 901 PALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIW 6hio A 4.2 BS01 SRO A 1 W63 Y64 R65 Y126 W55 Y56 R57 Y118 ? 0004888,0005216,0005230,0006811,0015276,0016020,0034220,0045211 Ki=361nM, EC50=3400nM P23979 30401839 502 QPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWIRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIAW 6hio A 4.2 BS02 SRO E 1 W156 Y207 W148 Y199 ? 0004888,0005216,0005230,0006811,0015276,0016020,0034220,0045211 Ki=361nM, EC50=3400nM P23979 30401839 901 QPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWIRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIAW 6hio B 4.2 BS01 SRO A 1 W156 Y207 W148 Y199 ? 0004888,0005216,0005230,0006811,0015276,0016020,0034220,0045211 Ki=361nM, EC50=3400nM P23979 30401839 502 QPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWIRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIAW 6hio B 4.2 BS02 SRO B 1 W63 Y64 R65 Y126 W55 Y56 R57 Y118 ? 0004888,0005216,0005230,0006811,0015276,0016020,0034220,0045211 Ki=361nM, EC50=3400nM P23979 30401839 502 QPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWIRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIAW 6hio C 4.2 BS01 SRO B 1 W156 Y207 W148 Y199 ? 0004888,0005216,0005230,0006811,0015276,0016020,0034220,0045211 Ki=361nM, EC50=3400nM P23979 30401839 502 QPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWIRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIAW 6hio C 4.2 BS02 SRO C 1 W63 Y64 R65 Y126 W55 Y56 R57 Y118 ? 0004888,0005216,0005230,0006811,0015276,0016020,0034220,0045211 Ki=361nM, EC50=3400nM P23979 30401839 502 QPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWIRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIAW 6hio D 4.2 BS01 SRO C 1 W156 Y207 W148 Y199 ? 0004888,0005216,0005230,0006811,0015276,0016020,0034220,0045211 Ki=361nM, EC50=3400nM P23979 30401839 502 QPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWIRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIAW 6hio D 4.2 BS02 SRO D 1 W63 Y64 Y126 W55 Y56 Y118 ? 0004888,0005216,0005230,0006811,0015276,0016020,0034220,0045211 Ki=361nM, EC50=3400nM P23979 30401839 901 QPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWIRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIAW 6hio E 4.2 BS01 SRO E 1 W63 Y64 R65 Y126 W55 Y56 R57 Y118 ? 0004888,0005216,0005230,0006811,0015276,0016020,0034220,0045211 Ki=361nM, EC50=3400nM P23979 30401839 901 QPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWIRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIAW 6hio E 4.2 BS02 SRO D 1 W156 Y207 W148 Y199 ? 0004888,0005216,0005230,0006811,0015276,0016020,0034220,0045211 Ki=361nM, EC50=3400nM P23979 30401839 901 QPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWIRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIAW 6hiq A 3.2 BS01 SRO A 1 W156 Y207 W148 Y199 ? 0004888,0005216,0005230,0006811,0015276,0016020,0034220,0045211 Ki=361nM, EC50=3400nM P23979 30401839 502 QPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWIRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWH 6hiq A 3.2 BS02 SRO B 1 W63 Y64 W55 Y56 ? 0004888,0005216,0005230,0006811,0015276,0016020,0034220,0045211 Ki=361nM, EC50=3400nM P23979 30401839 502 QPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWIRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWH 6hiq B 3.2 BS01 SRO B 1 W156 Y207 W148 Y199 ? 0004888,0005216,0005230,0006811,0015276,0016020,0034220,0045211 Ki=361nM, EC50=3400nM P23979 30401839 502 QPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWIRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWH 6hiq C 3.2 BS01 SRO C 1 W156 Y207 W148 Y199 ? 0004888,0005216,0005230,0006811,0015276,0016020,0034220,0045211 Ki=361nM, EC50=3400nM P23979 30401839 502 QPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWIRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWH 6hiq D 3.2 BS01 SRO D 1 W156 Y207 W148 Y199 ? 0004888,0005216,0005230,0006811,0015276,0016020,0034220,0045211 Ki=361nM, EC50=3400nM P23979 30401839 502 QPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWIRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWH 6hiq E 3.2 BS01 SRO A 1 W63 Y64 W55 Y56 ? 0004888,0005216,0005230,0006811,0015276,0016020,0034220,0045211 Ki=361nM, EC50=3400nM P23979 30401839 502 QPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWIRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWH 6hiq E 3.2 BS02 SRO E 1 W156 Y207 W148 Y199 ? 0004888,0005216,0005230,0006811,0015276,0016020,0034220,0045211 Ki=361nM, EC50=3400nM P23979 30401839 502 QPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWIRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWH 6khn A 2.293 BS02 SRO A 1 F127 Y359 G381 F107 Y335 G357 4.1.1.28 0005737,0006520,0006587,0016830,0016831,0019752,0030170,0036467,0036469,0042427 Q6ZJK7 32595985 602 TFQPLNADDVRSYLHKAVDFISDYYKSVESMPVLPNVKPGYLQDELRASPPTYSAPFDVTMKELRSSVVPGMTHWASPNFFAFFPSTNSAAAIAGDLIASAMNTVGFTWQASPAATEMEVLALDWLAQMLNLPTSFMNGRGTGGGVILGTTSEAMLVTLVAARDAALRRSGSDGVAGLHRLAVYAADQTHSTFFKACRLAGFDPANIRSIPTGAETDYGLDPARLLEAMQADADAGLVPTYVCATVGTTSSNAVDPVGAVADVAARFAAWVHVDAAYAGSACICPEFRHHLDGVERVDSISMSPHKWLMTCLDCTCLYVRDTHRLTGSLETNPEYLKNHASDSGEVTDLKDMQVGVGRRFRGLKLWMVMRTYGVAKLQEHIRSDVAMAKVFEDLVRGDDRFEVVVPRNFALVCFRIRAGAGAAAATEEDADEANRELMERLNKTGKAYVAHTVVGGRFVLRFAVGSSLQEEHHVRSAWELIKKTTTEMMN 6khn B 2.293 BS01 SRO A 1 F104 P105 S106 H329 K330 F84 P85 S86 H309 K310 4.1.1.28 0005737,0006520,0006587,0016830,0016831,0019752,0030170,0036467,0036469,0042427 Q6ZJK7 32595985 602 TFQPLNADDVRSYLHKAVDFISDYYKSVESMPVLPNVKPGYLQDELRASPPTYSAPFDVTMKELRSSVVPGMTHWASPNFFAFFPSTNSAAAIAGDLIASAMNTVGFTWQASPAATEMEVLALDWLAQMLNLPTSFMNRTGEGRGTGGGVILGTTSEAMLVTLVAARDAALRRSGSDGVAGLHRLAVYAADQTHSTFFKACRLAGFDPANIRSIPTGAETDYGLDPARLLEAMQADADAGLVPTYVCATVGTTSSNAVDPVGAVADVAARFAAWVHVDAAYAGSACICPEFRHHLDGVERVDSISMSPHKWLMTCLDCTCLYVRDTHRLGEVTDLKDMQVGVGRRFRGLKLWMVMRTYGVAKLQEHIRSDVAMAKVFEDLVRGDDRFEVVVPRNFALVCFRIRAGAGAAAATEEDADEANRELMERLNKTGKAYVAHTVVGGRFVLRFAVGSSLQEEHHVRSAWELIKKTTTEMMN 6y5a A 2.8 BS01 SRO A 1 W63 Y64 Y126 K127 W56 Y57 Y119 K120 ? 0004888,0005216,0005230,0006811,0015276,0016020,0034220,0045211 Ki=361nM, EC50=3400nM P23979 33594077 501 TQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHSS 6y5a A 2.8 BS02 SRO B 1 W156 Y207 W149 Y200 ? 0004888,0005216,0005230,0006811,0015276,0016020,0034220,0045211 Ki=361nM, EC50=3400nM P23979 33594077 501 TQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHSS 6y5a B 2.8 BS01 SRO C 1 W156 Y207 W149 Y200 ? 0004888,0005216,0005230,0006811,0015276,0016020,0034220,0045211 Ki=361nM, EC50=3400nM P23979 33594077 501 TQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHSS 6y5a B 2.8 BS02 SRO B 1 W63 Y64 R65 Y126 K127 W56 Y57 R58 Y119 K120 ? 0004888,0005216,0005230,0006811,0015276,0016020,0034220,0045211 Ki=361nM, EC50=3400nM P23979 33594077 501 TQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHSS 6y5a C 2.8 BS01 SRO C 1 W63 Y64 R65 Y126 K127 W56 Y57 R58 Y119 K120 ? 0004888,0005216,0005230,0006811,0015276,0016020,0034220,0045211 Ki=361nM, EC50=3400nM P23979 33594077 501 TQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHSS 6y5a C 2.8 BS02 SRO D 1 W156 Y207 W149 Y200 ? 0004888,0005216,0005230,0006811,0015276,0016020,0034220,0045211 Ki=361nM, EC50=3400nM P23979 33594077 501 TQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHSS 6y5a D 2.8 BS01 SRO D 1 W63 Y64 R65 Y126 K127 W56 Y57 R58 Y119 K120 ? 0004888,0005216,0005230,0006811,0015276,0016020,0034220,0045211 Ki=361nM, EC50=3400nM P23979 33594077 501 TQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILVRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHSS 6y5a D 2.8 BS02 SRO E 1 W156 Y207 W149 Y200 ? 0004888,0005216,0005230,0006811,0015276,0016020,0034220,0045211 Ki=361nM, EC50=3400nM P23979 33594077 501 TQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILVRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHSS 6y5a E 2.8 BS01 SRO A 1 W156 Y207 W149 Y200 ? 0004888,0005216,0005230,0006811,0015276,0016020,0034220,0045211 Ki=361nM, EC50=3400nM P23979 33594077 501 TQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHSS 6y5a E 2.8 BS02 SRO E 1 W63 Y64 R65 Y126 K127 W56 Y57 R58 Y119 K120 ? 0004888,0005216,0005230,0006811,0015276,0016020,0034220,0045211 Ki=361nM, EC50=3400nM P23979 33594077 501 TQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHSS 7bs2 A 1.8 BS02 SRO A 1 D194 S195 C196 Q197 S200 W216 D171 S172 C173 Q174 S177 W193 H63 D107 Q197 G198 D199 S200 G201 H40 D84 Q174 G175 D176 S177 G178 3.4.21.4 0004175,0004252,0005515,0005576,0005615,0006508,0007586,0008236,0046872,0097180,0097655 P00760 34094189 302 IVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAAHCYKSGIQVRLGEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLNSRVASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKSAYPGQITSNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQKNKPGVYTKVCNYVSWIKQTIASN 7bs9 A 1.05 BS02 SRO A 1 D194 S195 C196 Q197 S200 W216 G219 C220 D171 S172 C173 Q174 S177 W193 G196 C197 H63 D107 Q197 G198 D199 S200 G201 H40 D84 Q174 G175 D176 S177 G178 3.4.21.4 0004175,0004252,0005515,0005576,0005615,0006508,0007586,0008236,0046872,0097180,0097655 P00760 34094189 302 IVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAAHCYKSGIQVRLGEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLNSRVASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKSAYPGQITSNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQKNKPGVYTKVCNYVSWIKQTIASN 7cfp A 1.6 BS02 SRO B 1 F149 P173 F119 P143 ? 0000122,0000123,0001501,0005515,0005634,0005654,0006094,0006325,0006355,0006357,0035064,0035097,0042393,0042800,0044545,0044665,0044666,0045722,0045815,0045893,0045995,0048188,0051302,0051726,0071339,0072686,0090043,0140672 P61964 34144982 101 VKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 7cfq A 1.6 BS02 SRO B 1 F149 P173 F119 P143 ? 0000122,0000123,0001501,0005515,0005634,0005654,0006094,0006325,0006355,0006357,0035064,0035097,0042393,0042800,0044545,0044665,0044666,0045722,0045815,0045893,0045995,0048188,0051302,0051726,0071339,0072686,0090043,0140672 P61964 34144982 101 VKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 7dal B 2.5 BS02 SRO B 1 D189 D226 D81 D118 2.3.1.87 0008080,0016747 Q5KQI6 33682300 302 EELVLLERTLEQIIFSSAGDVNVYDLQALCDKVGWPRRPLTKIAASLRNSYLVATLHSVTKQLIGMARATSDHAFNATIWDVLVDPSYQGQGLGKALMEKVIRTLLQRDISNITLFADNKVVDFYKNLGFEADPQGIKGMFWYPRF 7e2y R 3.0 BS01 SRO R 1 D116 C120 S199 F361 D82 C86 S155 F222 ? 0001586,0001662,0004930,0004993,0005506,0005515,0005886,0007186,0007187,0007198,0007210,0007214,0007268,0008284,0009055,0014062,0016020,0019229,0020037,0022900,0030425,0030594,0035640,0042053,0042428,0042597,0042995,0045202,0046872,0046883,0050795,0051378,0090722,0099589 P08908,P0ABE7 33762731 501 YQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSIWHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKII 7e32 R 2.9 BS01 SRO R 1 D118 C122 S201 W314 F317 F318 S321 Y346 D85 C89 S159 W228 F231 F232 S235 Y260 ? 0001586,0004930,0004993,0005506,0005886,0006939,0007186,0007187,0007193,0007198,0007268,0009055,0014827,0016020,0020037,0022900,0030425,0030594,0040012,0042310,0042597,0045202,0046872,0050795,0099589 P0ABE7,P28221 33762731 401 LQALKISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASIWHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLFWRDCLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFSALERKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIV 7li9 A 3.9 BS01 SRO A 1 I172 F341 T439 G442 I94 F263 T361 G364 ? 0016020 P31645 34851672 909 RETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIITPGTFKERIIKSITPETP 7li9 A 3.9 BS02 SRO A 2 E494 Y495 P499 F556 S559 P561 E416 Y417 P421 F478 S481 P483 ? 0016020 P31645 34851672 910 RETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIITPGTFKERIIKSITPETP 7lia A 3.3 BS01 SRO A 1 I172 A173 F341 T439 G442 I94 A95 F263 T361 G364 ? 0016020 P31645 34851672 901 RETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIITPGTFKERIIKSITPETP 7lia A 3.3 BS05 SRO A 2 E494 Y495 P499 F556 S559 P561 Y579 E416 Y417 P421 F478 S481 P483 Y501 ? 0016020 P31645 34851672 905 RETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIITPGTFKERIIKSITPETP 7mgw A 3.5 BS02 SRO A 1 Y95 D98 A169 I172 A173 F335 F341 S438 T439 G442 Y17 D20 A91 I94 A95 F257 F263 S360 T361 G364 ? 0016020 P31645 34851672 712 RETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIITPGTFKERIIKSITPE 7mgw A 3.5 BS03 SRO A 2 E494 Y495 P499 F556 P561 Y579 E416 Y417 P421 F478 P483 Y501 ? 0016020 P31645 34851672 715 RETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIITPGTFKERIIKSITPE 7tx8 A 2.51 BS01 SRO A 1 F158 E162 G177 R178 Y180 L188 M191 F260 D261 F156 E160 G175 R176 Y178 L186 M189 F258 D259 ? 0005549,0005576,0035821,0090729 B6DDQ8 35568118 401 RWTALTPEETLFIYTRCQEEHLPADNNSRKTYIENWHQWKLQPNDHVTQCYTKCVLEGLELYDGKQKKFRPGRVSSQHVAYQFLNGATADEVAKYKGAIDALEPASDSCEDLYMAYFPVHETFVNVTRKLYHGTVEGAARVYNSDPNLKRKNESLFTYCEKHVYGDQNREDMCRGRRYELTGSDELRNMIECVFRGLRYIKHGDINIDEIVRDFDHINRGDLEPRVRTILSDCRGIQPYDYYSCLINSDIREEFKLAFDYRDVRSADYAYIVKGNTYDAQKVIAEMNKVEKHVCG 7tx8 B 2.51 BS01 SRO B 1 F158 E162 G177 R178 Y180 M191 F260 D261 F155 E159 G174 R175 Y177 M188 F257 D258 ? 0005549,0005576,0035821,0090729 B6DDQ8 35568118 401 RWTALTPEETLFIYTRCQEEHLPANNSRKTYIENWHQWKLQPNDHVTQCYTKCVLEGLELYDGKQKKFRPGRVSSQHVAYQFLNGATADEVAKYKGAIDALEPASDSCEDLYMAYFPVHETFVNVTRKLYHGTVEGAARVYNSDPNLKRKNESLFTYCEKHVYGDQNREDMCRGRRYELTGSDELRNMIECVFRGLRYIKHGDINIDEIVRDFDHINRGDLEPRVRTILSDCRGIQPYDYYSCLINSDIREEFKLAFDYRDVRSADYAYIVKGNTYDAQKVIAEMNKVEKHVCG 7tx8 C 2.51 BS01 SRO C 1 F158 E162 G177 R178 M191 D261 F155 E159 G174 R175 M188 D258 ? 0005549,0005576,0035821,0090729 B6DDQ8 35568118 401 RWTALTPEETLFIYTRCQEEHLPANNSRKTYIENWHQWKLQPNDHVTQCYTKCVLEGLELYDGKQKKFRPGRVSSQHVAYQFLNGATADEVAKYKGAIDALEPASDSCEDLYMAYFPVHETFVNVTRKLYHGTVEGAARVYNSDPNLKRKNESLFTYCEKHVYGDQNREDMCRGRRYELTGSDELRNMIECVFRGLRYIKHGDINIDEIVRDFDHINRGDLEPRVRTILSDCRGIQPYDYYSCLINSDIREEFKLAFDYRDVRSADYAYIVKGNTYDAQKVIAEMNKVEKHVCG 7tx8 D 2.51 BS01 SRO D 1 F158 E162 G177 R178 Y180 M191 D261 F154 E158 G173 R174 Y176 M187 D257 ? 0005549,0005576,0035821,0090729 B6DDQ8 35568118 301 RWTALTPEETLFIYTRCQEEHLPANSRKTYIENWHQWKLQPNDHVTQCYTKCVLEGLELYDGKQKKFRPGRVSSQHVAYQFLNGATADEVAKYKGAIDALEPASDSCEDLYMAYFPVHETFVNVTRKLYHGTVEGAARVYNSDPNLKRKNESLFTYCEKHVYGDQNREDMCRGRRYELTGSDELRNMIECVFRGLRYIKHGDINIDEIVRDFDHINRGDLEPRVRTILSDCRGIQPYDYYSCLINSDIREEFKLAFDYRDVRSADYAYIVKGNTYDAQKVIAEMNKVEKHVCG 7wb7 A 1.45 BS01 SRO A 1 D194 S195 C196 Q197 S200 W216 G219 C220 D171 S172 C173 Q174 S177 W193 G196 C197 3.4.21.4 0004175,0004252,0005515,0005576,0005615,0006508,0007586,0008236,0046872,0097180,0097655 P00760 35647681 301 IVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAAHCYKSGIQVRLGEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLNSRVASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKSAYPGQITSNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQKNKPGVYTKVCNYVSWIKQTIASN 7wc4 A 3.2 BS04 SRO A 1 W151 D155 W85 D89 ? 0004930,0004993,0005506,0005886,0007186,0009055,0016020,0020037,0022900 P28223 35084960 1409 SLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTAKIWHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEAADLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAGDILVGQIDDALKLANEGKVKEAQAAAEQLKTTINAYIQKYGQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLNSAVNPLVYTLFNKTYRSAFSRYIQCQYKE 7xt8 R 3.1 BS04 SRO R 1 D99 V100 T103 T104 C195 F274 N278 D82 V83 T86 T87 C178 F240 N244 ? 0004930,0004993,0005506,0005515,0005737,0005768,0005886,0007186,0007187,0007188,0007189,0007192,0007268,0009055,0010008,0016020,0020037,0022900,0030277,0030425,0030594,0032098,0042597,0046872,0070254,0098664,0098794,0098978,0099589,0120056,0150052 P0ABE7,Q13639 35714614 408 KVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCC 7xt9 R 3.2 BS04 SRO R 1 D99 V100 T103 T104 C195 F274 F275 N278 D82 V83 T86 T87 C178 F240 F241 N244 ? 0004930,0004993,0005506,0005515,0005737,0005768,0005886,0007186,0007187,0007188,0007189,0007192,0007268,0009055,0010008,0016020,0020037,0022900,0030277,0030425,0030594,0032098,0042597,0046872,0070254,0098664,0098794,0098978,0099589,0120056,0150052 P0ABE7,Q13639 35714614 407 KVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCC 7xta R 3.2 BS01 SRO R 1 D99 T103 C195 F274 F275 N278 D82 T86 C178 F229 F230 N233 ? 0004930,0004993,0005506,0005515,0005737,0005768,0005886,0007186,0007187,0007188,0007189,0007192,0007268,0009055,0010008,0016020,0020037,0022900,0030277,0030425,0030594,0032098,0042597,0046872,0070254,0098664,0098794,0098978,0099589,0120056,0150052 P0ABE7,Q13639 35714614 401 KVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQITKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCC 7xtb R 3.3 BS01 SRO R 1 C110 A192 F284 N288 C85 A167 F224 N228 ? 0004930,0004969,0004993,0005506,0005515,0005886,0005929,0007186,0007187,0007188,0007192,0007268,0009055,0016020,0020037,0021795,0022900,0030425,0030594,0032008,0042597,0045202,0046872,0098664 P0ABE7,P50406 35714614 501 SGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCP 7ys6 A 3.0 BS01 SRO A 1 D106 C110 N288 D76 C80 N221 ? 0004930,0004993,0007186,0016020 P50406 36989299 401 AALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTLKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLP 8c20 B 3.5 BS01 SRO B 1 W156 F199 Y207 W139 F182 Y190 P23979 501 ALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNKLSIPTDSIWVPDILINEFVDVIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKRPVPDWLRHLVLDRIAWILEVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHSS 8c20 D 3.5 BS01 SRO D 1 F199 I201 F185 I187 P23979 501 LLRLSDHLLANYGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHQRPVPDWLRHLVLDRIAWEVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHSS 8c21 B 3.6 BS01 SRO B 1 S155 W156 F199 Y207 S148 W149 F192 Y200 P23979 501 TQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHSS 8c21 B 3.6 BS02 SRO C 1 W63 R65 W56 R58 P23979 501 TQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHSS 8c21 C 3.6 BS01 SRO C 1 N101 W156 Y207 N94 W149 Y200 P23979 501 TQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHSS 8frz A 2.75 BS01 SRO A 1 W63 Y64 Y126 K127 W56 Y57 Y119 K120 ? 0004888,0005216,0005230,0005886,0006811,0007210,0015276,0016020,0022850,0032154,0034220,0042802,0045202,0045211,0051378,0098662,0099505,0099507,0140227,1904602 P23979 38177669 501 TQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILAVRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHYS 8frz A 2.75 BS02 SRO E 1 W156 Y207 W149 Y200 ? 0004888,0005216,0005230,0005886,0006811,0007210,0015276,0016020,0022850,0032154,0034220,0042802,0045202,0045211,0051378,0098662,0099505,0099507,0140227,1904602 P23979 38177669 501 TQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILAVRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHYS 8frz B 2.75 BS01 SRO A 1 W156 Y207 W149 Y200 ? 0004888,0005216,0005230,0005886,0006811,0007210,0015276,0016020,0022850,0032154,0034220,0042802,0045202,0045211,0051378,0098662,0099505,0099507,0140227,1904602 P23979 38177669 501 TQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILAVRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHYS 8frz B 2.75 BS02 SRO B 1 W63 Y64 Y126 K127 W56 Y57 Y119 K120 ? 0004888,0005216,0005230,0005886,0006811,0007210,0015276,0016020,0022850,0032154,0034220,0042802,0045202,0045211,0051378,0098662,0099505,0099507,0140227,1904602 P23979 38177669 501 TQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILAVRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHYS 8frz C 2.75 BS01 SRO B 1 W156 Y207 W149 Y200 ? 0004888,0005216,0005230,0005886,0006811,0007210,0015276,0016020,0022850,0032154,0034220,0042802,0045202,0045211,0051378,0098662,0099505,0099507,0140227,1904602 P23979 38177669 501 TQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILAVRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHYS 8frz C 2.75 BS02 SRO C 1 W63 Y64 Y126 K127 W56 Y57 Y119 K120 ? 0004888,0005216,0005230,0005886,0006811,0007210,0015276,0016020,0022850,0032154,0034220,0042802,0045202,0045211,0051378,0098662,0099505,0099507,0140227,1904602 P23979 38177669 501 TQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILAVRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHYS 8frz D 2.75 BS01 SRO C 1 W156 Y207 W149 Y200 ? 0004888,0005216,0005230,0005886,0006811,0007210,0015276,0016020,0022850,0032154,0034220,0042802,0045202,0045211,0051378,0098662,0099505,0099507,0140227,1904602 P23979 38177669 501 TQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILAVRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHYS 8frz D 2.75 BS02 SRO D 1 W63 Y64 Y126 K127 W56 Y57 Y119 K120 ? 0004888,0005216,0005230,0005886,0006811,0007210,0015276,0016020,0022850,0032154,0034220,0042802,0045202,0045211,0051378,0098662,0099505,0099507,0140227,1904602 P23979 38177669 501 TQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILAVRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHYS 8frz E 2.75 BS01 SRO D 1 W156 Y207 W149 Y200 ? 0004888,0005216,0005230,0005886,0006811,0007210,0015276,0016020,0022850,0032154,0034220,0042802,0045202,0045211,0051378,0098662,0099505,0099507,0140227,1904602 P23979 38177669 501 TQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILAVRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHYS 8frz E 2.75 BS02 SRO E 1 W63 Y64 Y126 K127 W56 Y57 Y119 K120 ? 0004888,0005216,0005230,0005886,0006811,0007210,0015276,0016020,0022850,0032154,0034220,0042802,0045202,0045211,0051378,0098662,0099505,0099507,0140227,1904602 P23979 38177669 501 TQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILAVRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHYS 8fsb A 2.75 BS01 SRO B 1 W63 Y126 W57 Y120 ? 0004888,0005216,0005230,0005886,0006811,0007210,0015276,0016020,0022850,0032154,0034220,0042802,0045202,0045211,0051378,0098662,0099505,0099507,0140227,1904602 P23979 38177669 501 TTQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILAVRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHYSENL 8fsb B 2.75 BS01 SRO B 1 W156 I201 W150 I195 ? 0004888,0005216,0005230,0005886,0006811,0007210,0015276,0016020,0022850,0032154,0034220,0042802,0045202,0045211,0051378,0098662,0099505,0099507,0140227,1904602 P23979 38177669 501 TTQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILAVRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHYSENL 8fsb B 2.75 BS02 SRO C 1 W63 Y126 W57 Y120 ? 0004888,0005216,0005230,0005886,0006811,0007210,0015276,0016020,0022850,0032154,0034220,0042802,0045202,0045211,0051378,0098662,0099505,0099507,0140227,1904602 P23979 38177669 501 TTQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILAVRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHYSENL 8fsb C 2.75 BS01 SRO D 1 W63 Y126 W57 Y120 ? 0004888,0005216,0005230,0005886,0006811,0007210,0015276,0016020,0022850,0032154,0034220,0042802,0045202,0045211,0051378,0098662,0099505,0099507,0140227,1904602 P23979 38177669 501 TTQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILAVRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHYSENL 8fsb D 2.75 BS01 SRO D 1 W156 I201 W150 I195 ? 0004888,0005216,0005230,0005886,0006811,0007210,0015276,0016020,0022850,0032154,0034220,0042802,0045202,0045211,0051378,0098662,0099505,0099507,0140227,1904602 P23979 38177669 501 TTQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILAVRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHYSENL 8fsb D 2.75 BS02 SRO E 1 W63 Y126 W57 Y120 ? 0004888,0005216,0005230,0005886,0006811,0007210,0015276,0016020,0022850,0032154,0034220,0042802,0045202,0045211,0051378,0098662,0099505,0099507,0140227,1904602 P23979 38177669 501 TTQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILAVRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHYSENL 8fsb E 2.75 BS01 SRO A 1 W63 Y126 W57 Y120 ? 0004888,0005216,0005230,0005886,0006811,0007210,0015276,0016020,0022850,0032154,0034220,0042802,0045202,0045211,0051378,0098662,0099505,0099507,0140227,1904602 P23979 38177669 504 TTQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILAVRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHYSENL 8gdl A 1.75 BS01 SRO A 1 F7 V8 M9 F111 D227 L228 D231 N253 F255 Q265 F6 V7 M8 F110 D226 L227 D230 N252 F254 Q264 3.1.3.2 A2IA89 38110569 401 DLKFVFVMARGGDFVAGDYAGGPKIINKEAKDSELTEQGKQEAFQLGTKLSGLYKTKLGVSKWDSKTYWPVAISQKRAQVSTLITGAGLEGDQSKRDKTWTDQELKATSFPAMESFSRFIKPSECPNYLKELLAQQGEITTIVKECISSVQQVKSKYPAVDEKMPQHIWLAYETLKKLKRQQPSSSTWMTDDLMKNLRECSAKITWLATTKTDTLRKLSGGLLLNDLFNDMDQITQGKAQPNAPGGKDSKLNVFTVSQFLVISQLAAFMPEGSKLNNKAVTASDIYPEDGSHVDIEMYQENNKWSVKLVYVSGKDKQPQTITLPGCQEKCPYEQFKSALQKYKITDEEHQKACKN 8gdl B 1.75 BS01 SRO B 1 F7 V8 M9 D227 L228 D231 N253 F255 Q265 F6 V7 M8 D226 L227 D230 N252 F254 Q264 3.1.3.2 A2IA89 38110569 401 DLKFVFVMARGGDFVAGDYAGGPKIINKEAKDSELTEQGKQEAFQLGTKLSGLYKTKLGVSKWDSKTYWPVAISQKRAQVSTLITGAGLEGDQSKRDKTWTDQELKATSFPAMESFSRFIKPSECPNYLKELLAQQGEITTIVKECISSVQQVKSKYPAVDEKMPQHIWLAYETLKKLKRQQPSSSTWMTDDLMKNLRECSAKITWLATTKTDTLRKLSGGLLLNDLFNDMDQITQGKAQPNAPGGKDSKLNVFTVSQFLVISQLAAFMPEGSKLNNKAVTASDIYPEDGSHVDIEMYQENNKWSVKLVYVSGKDKQPQTITLPGCQEKCPYEQFKSALQKYKITDEEHQKACKN 8jsw A 2.84 BS01 SRO A 1 E312 Y341 E222 Y251 ? 0016020,0022857,0042908,0042910,0055085 Q05940 38081299 501 SRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHENVQVGLLFASKATVQLITNPFIGLLTNRIGYPIPIFAGFCIMFVSTIMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGNVMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMIIVGVSILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDILFAPLCFFLRSPP 8t6b A 3.72 BS01 SRO A 1 V232 I308 E312 F334 Y433 V142 I218 E222 F244 Y343 ? 0001975,0002552,0002553,0005335,0005515,0005813,0005886,0006836,0007268,0007626,0008021,0008504,0009636,0009791,0015311,0015842,0015844,0015872,0016020,0022857,0030424,0030425,0030667,0030672,0031410,0042137,0042908,0042910,0042995,0043195,0043231,0045202,0051610,0051615,0055085,0070083,0098691,0098700,0099123,1902600,1903427 Q05940 37914936 601 RKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHNENVQVGLLFASKATVQLITNPFIGLLTNRIGYPIPIFAGFCIMFVSTIMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGNVMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMIIVGVSILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVSGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDILFAPLCFFLRSPPAKE 8tgn A 3.3 BS01 SRO A 1 L240 V316 E320 F342 L140 V216 E220 F242 ? 0005335,0005783,0005789,0006836,0006837,0008504,0015311,0015842,0015844,0016020,0022857,0030672,0031410,0042908,0042910,0043195,0045202,0051610,0051649,0055085,0070083,1902600 P54219 38499039 601 SRQLVLVVVFVALLLDNMLFTVVVPIVPTFLYDEEITRVGVLFASKAVMQLLVNPFVGPLTNRIGYHIPMFAGFVIMFLSTVMFAFSGTYTLLFVARTLQGIGSSFSSVAGLGMLASVYTDDHERGRAMGTALGGLALGLLVGAPFGSVMYEFVGKSAPFLILAFLALLDGALQLCILQPSKVSPESAKGTPLFMLLKDPYILVAAGSICFANMGVAILEPTLPIWMMQTMCSPKWQLGLAFLPASVSYLIGTNLFGVLANKMGRWLCSLIGMLVVGTSLLCVPLAHNIFGLIGPNAGLGLAIGMVDSSMMPIMGHLVDLRHTSVYGSVYAIADVAFCMGFAIGPSTGGAIVKAIGFPWLMVITGVINIVYAPLCYYLRSPPAK 8wlm A 3.57 BS01 SRO A 1 L228 V232 N305 I308 E312 Y341 Y433 L136 V140 N213 I216 E220 Y249 Y341 ? 0001975,0002552,0002553,0005335,0005515,0005813,0005886,0006836,0007268,0007626,0008021,0008504,0009636,0009791,0015311,0015842,0015844,0015872,0016020,0030424,0030425,0030667,0030672,0031410,0042137,0042995,0043195,0043231,0045202,0051610,0051615,0070083,0098691,0098700,0099123,1902600,1903427 Q05940 501 SRRSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSVQVGLLFASKATVQLITNPFIGLLTNRIGYPIPIFAGFCIMFVSTIMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGNVMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMIIVGVSILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDILFAPLCFFLRSPP